Journal of investigative medicine high impact case reports最新文献_第5页

Spontaneous Regression of Rosai-Dorfman Disease Presenting as a Thigh Mass With Vascular Involvement: A Case Report. Rosai-Dorfman病自发性消退表现为累及血管的大腿肿块1例报告。

IF 0.8

Journal of investigative medicine high impact case reports Pub Date : 2025-01-01 Epub Date: 2025-10-09 DOI: 10.1177/23247096251374516

Malek Bouhani, Hanen Bouaziz, Nadia Boujelbene, Nayssem Khessairi, Olfa Jaidane, Tarek Ben Dhiab

{"title":"Spontaneous Regression of Rosai-Dorfman Disease Presenting as a Thigh Mass With Vascular Involvement: A Case Report.","authors":"Malek Bouhani, Hanen Bouaziz, Nadia Boujelbene, Nayssem Khessairi, Olfa Jaidane, Tarek Ben Dhiab","doi":"10.1177/23247096251374516","DOIUrl":"https://doi.org/10.1177/23247096251374516","url":null,"abstract":"Rosai-Dorfman disease (RDD) is a rare non-Langerhansian histiocytosis, classically manifesting as massive cervical lymphadenopathy. Isolated extra-nodal forms, particularly in soft tissues, are exceptional and may simulate a malignant tumor. We report the case of a 56-year-old patient presenting with a painless mass of the right thigh that had been evolving for several weeks. Clinical examination revealed a deep mass measuring approximately 10 cm. Magnetic resonance imaging showed a tissue formation encompassing the femoral vessels, responsible for thrombosis with vascular stenosis. A surgical biopsy was performed. Histological analysis, coupled with immunohistochemistry, confirmed the diagnosis of RDD. Anticoagulant therapy with apixaban was instituted for the venous thrombosis. The evolution was marked by spontaneous regression of the mass without recourse to additional surgery. This case illustrates an atypical presentation of RDD through isolated involvement of the soft tissues of the thigh, complicated by deep venous thrombosis. Diagnosis is based on histopathological examination. Treatment is individualized and may be limited to monitoring in nonprogressive forms. RDD must be included in the differential diagnosis of deep soft tissue masses. Early recognition can avoid invasive treatment.","PeriodicalId":16198,"journal":{"name":"Journal of investigative medicine high impact case reports","volume":"13 ","pages":"23247096251374516"},"PeriodicalIF":0.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145251350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Rare Case of Scleroderma Renal Crisis. 罕见硬皮病肾危象1例。

IF 0.9

Journal of investigative medicine high impact case reports Pub Date : 2025-01-01 Epub Date: 2025-04-25 DOI: 10.1177/23247096251336565

Ariel Ahl, Harendra Ipalawatte, Saif Ghias, Arian Gower

{"title":"A Rare Case of Scleroderma Renal Crisis.","authors":"Ariel Ahl, Harendra Ipalawatte, Saif Ghias, Arian Gower","doi":"10.1177/23247096251336565","DOIUrl":"https://doi.org/10.1177/23247096251336565","url":null,"abstract":"Scleroderma renal crisis is a rare, life-threatening complication of systemic sclerosis. It is characterized by pronounced hypertension, acute kidney injury, and thrombotic microangiopathy. Although its prevalence has decreased over the last decade, and death rates have declined since the introduction of treatment with Angiotensin converting enzyme (ACE)-inhibitors, it remains a challenge due to lack of prevention and rapid progression despite intervention in those who develop renal crisis. We present a 46-year-old female with history of rheumatoid arthritis and scleroderma who presented to the Emergency Department (ED) with complaints of a severe headache associated with nausea and vomiting that started earlier in the day. Patient presented with a blood pressure of 180/103 that did not improve with use of anti-hypertensive medications. Labs were remarkable for anemia and decreased renal function. A CT of the abdomen and pelvis without contrast demonstrated distention of distal esophagus with possible underlying esophageal dysmotility due to degree of distention and dependent areas of tractional bronchiectasis in the bilateral lower lobes that can be seen in the setting of early interstitial lung disease. Treatment with an ACE-inhibitor was initiated, with improvement in blood pressure and resolution of headache. This case demonstrates another rare case and illustrates the importance of rapid recognition and treatment.","PeriodicalId":16198,"journal":{"name":"Journal of investigative medicine high impact case reports","volume":"13 ","pages":"23247096251336565"},"PeriodicalIF":0.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12035258/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144017639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Giant Right Atrial Myxoma Presenting With Right Heart Failure. 巨大右心房黏液瘤表现为右心衰。

IF 0.9

Journal of investigative medicine high impact case reports Pub Date : 2025-01-01 Epub Date: 2025-03-27 DOI: 10.1177/23247096251329706

Priya Ramcharan, Arun Katwaroo, Matthew Maharaj, Valmiki Seecheran, Dayna Lalchansingh, Rajeev Seecheran, Shari Khan, Naveen Seecheran

引用次数: 0

Biopsy Confirmed Skin Drug Eruption in Setting of Ticagrelor Use. 使用替格瑞洛后，活检证实皮肤药疹。

IF 0.9

Journal of investigative medicine high impact case reports Pub Date : 2025-01-01 Epub Date: 2025-06-18 DOI: 10.1177/23247096251350547

Dre E Steinwehr, Jena M Gales, Anya R de Leeuw, Derek S Anderson, Christopher R Cunningham, Aaron A H Smith

{"title":"Biopsy Confirmed Skin Drug Eruption in Setting of Ticagrelor Use.","authors":"Dre E Steinwehr, Jena M Gales, Anya R de Leeuw, Derek S Anderson, Christopher R Cunningham, Aaron A H Smith","doi":"10.1177/23247096251350547","DOIUrl":"10.1177/23247096251350547","url":null,"abstract":"When there is concern that a rash may be a drug eruption reaction, there are many well-known culprits such as antibiotics and phenytoin. When an uncommon or previously unknown offending medication is being considered to have caused a drug eruption, diagnostic skin biopsy can help confirm the diagnosis. Our patient is a 54-year-old female with past medical history of prediabetes and obesity. She had ST segment-elevation myocardial infarction that was treated appropriately with timely percutaneous coronary intervention, which included angioplasty and drug-eluting stent placement. She was maintained on treatment regimen, and over the next 3 months, she developed a worsening maculopapular rash across her torso and upper extremities. Her biopsy showed superficial and mid-dermal perivascular lymphohistiocytic inflammation with focal spongiosis and scattered eosinophils, a common pathologic finding seen in drug eruptions. Although the patient was not taking any well-known offending agents, her ticagrelor was discontinued and she was transitioned to clopidogrel. Shortly after the transition, the patient's drug rash resolved without recurrence. Drug eruptions are a common etiology for rashes leading to presentation in primary care clinics. Our patient illustrates an exceedingly rare case of ticagrelor-induced drug reaction, as a review of the literature shows only 2 previously published case reports.","PeriodicalId":16198,"journal":{"name":"Journal of investigative medicine high impact case reports","volume":"13 ","pages":"23247096251350547"},"PeriodicalIF":0.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12177242/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144317121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Case Report: Two Cases of Kikuchi Disease in West Texas With Non-Self-Limited Disease. 病例报告：两例菊池病在得克萨斯州西部与非自限性疾病。

IF 0.9

Journal of investigative medicine high impact case reports Pub Date : 2025-01-01 Epub Date: 2025-06-25 DOI: 10.1177/23247096251350580

Pitchaporn Yingchoncharoen, Nattanicha Chaisrimaneepan, Miriam Paz, Alexandra Hoffman, Kuldeep Lohano, Safaa Labib, John Pixley

引用次数: 0

Exceptional Long-term Response to Immunotherapy in an African American Man With STK11/TP53/RB1-Mutated Metastatic Lung Adenocarcinoma. 非裔美国人STK11/TP53/ rb1突变转移性肺腺癌患者对免疫治疗的特殊长期反应

IF 0.9

Journal of investigative medicine high impact case reports Pub Date : 2025-01-01 Epub Date: 2025-05-31 DOI: 10.1177/23247096251346830

Yaolin Zhou, Maneesh Gaddam, Sunil Badami

{"title":"Exceptional Long-term Response to Immunotherapy in an African American Man With STK11/TP53/RB1-Mutated Metastatic Lung Adenocarcinoma.","authors":"Yaolin Zhou, Maneesh Gaddam, Sunil Badami","doi":"10.1177/23247096251346830","DOIUrl":"10.1177/23247096251346830","url":null,"abstract":"Immunotherapy has become the standard of care for advanced and resectable lung cancer, and specific mutations may predict immunotherapy response. For example, STK11 mutations, which are more common in African American patients, are associated with immunotherapy resistance. A 68-year-old African American man with stage IIIB lung adenocarcinoma with mediastinal lymph node involvement progressed on first-line concurrent carboplatin-based chemoradiotherapy. Molecular testing of the patient's subcarinal lymph node tissue revealed STK11 S216F, TP53 R273L, and RB1 splice site mutations; high tumor mutation burden (19.0 mutations/Mb); and high PD-L1 22c3 expression (TPS 70%, 2+ intensity). Treatment with carboplatin-based chemotherapy with radiation therapy failed to control the disease, but the patient has tolerated and responded well to intravenous pembrolizumab. Although STK11 mutations are associated with immunotherapy resistance, our patient demonstrated an exceptional and sustained response to immunotherapy for over two years. The patient's STK11/TP53 co-mutation, along with high TMB and PD-L1 22c3 TPS scores, may help explain his continued responsiveness to immunotherapy and longer survival. Importantly, incorporating genetic ancestry differences in mutation prevalence and the impact of specific mutations and co-mutations, may help ensure the equitable and optimal treatment of all patients with lung cancers.","PeriodicalId":16198,"journal":{"name":"Journal of investigative medicine high impact case reports","volume":"13 ","pages":"23247096251346830"},"PeriodicalIF":0.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12126655/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144191902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Polymyositis-Induced Atrial Flutter: A Rare and Unexpected Arrhythmia in an Idiopathic Inflammatory Myopathy. 多发性肌炎引起的心房扑动：特发性炎性肌病中一种罕见且意想不到的心律失常。

IF 0.9

Journal of investigative medicine high impact case reports Pub Date : 2025-01-01 Epub Date: 2025-07-14 DOI: 10.1177/23247096251357749

Arun Katwaroo, Matthew Maharaj, Priya Ramcharan, Valmiki Seecheran, Dayna Lalchansingh, Rajeev Seecheran, Avidesh Panday, Naveen Seecheran

引用次数: 0

A Case of Tuberculous Meningitis With Concomitant Spinal Co-infection With Tuberculosis and Aspergillosis. 结核性脑膜炎合并脊柱结核和曲霉病感染1例。

IF 0.9

Journal of investigative medicine high impact case reports Pub Date : 2025-01-01 Epub Date: 2025-03-26 DOI: 10.1177/23247096251329684

Candice A Sternberg, Andres Martinez, Ayoola Olayiwola, Maria Morel Almonte, Christine A Vu, Tanya Quiroz, Nadine Montreuil, Folusakin Ayoade

{"title":"A Case of Tuberculous Meningitis With Concomitant Spinal Co-infection With Tuberculosis and Aspergillosis.","authors":"Candice A Sternberg, Andres Martinez, Ayoola Olayiwola, Maria Morel Almonte, Christine A Vu, Tanya Quiroz, Nadine Montreuil, Folusakin Ayoade","doi":"10.1177/23247096251329684","DOIUrl":"10.1177/23247096251329684","url":null,"abstract":"Co-infection with Mycobacterium tuberculosis and Aspergillus in an immunocompetent host is rare but can occur. In this case, we present a patient with central nervous system tuberculosis (TB) and biopsy-proven spinal co-infections with TB and Aspergillosis. We highlight the complexities of treating a TB-Aspergillosis co-infection given drug-drug interactions between standard therapy for both conditions. Using susceptibilities for the Aspergillus and carefully monitoring drug levels of the antifungal agents, we were able to optimally treat the co-infection. This patient was ultimately discharged on isoniazid 1200 mg (15 mg/kg) daily, levofloxacin 750 mg daily, rifabutin 450 mg daily, and posaconazole 300 mg twice daily with a tentative plan to treat for at least 1 year with close outpatient follow-up. This case can serve as a guide for other providers who need to treat cases of TB and Aspergillosis co-infection by learning from our experience and paying attention to potential pitfalls.","PeriodicalId":16198,"journal":{"name":"Journal of investigative medicine high impact case reports","volume":"13 ","pages":"23247096251329684"},"PeriodicalIF":0.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11948546/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143730385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Silent but Deadly: A Conservative Approach to Pulmonary Artery Pseudoaneurysm. 沉默但致命：肺动脉假性动脉瘤的保守入路。

IF 0.8

Journal of investigative medicine high impact case reports Pub Date : 2025-01-01 Epub Date: 2025-09-20 DOI: 10.1177/23247096251368094

Conner Chapman, Yasser Hegazy, Zakaria Alagha, Beenish Najam, Ahmad Mahdi

引用次数: 0

High-Dose Simvastatin as a Potential Trigger for Angioedema: A Case Report for Broader Diagnostic Consideration. 高剂量辛伐他汀作为血管性水肿的潜在诱因：一个病例报告用于更广泛的诊断考虑。

IF 0.8

Journal of investigative medicine high impact case reports Pub Date : 2025-01-01 Epub Date: 2025-09-30 DOI: 10.1177/23247096251381198

Jhennis Megan Lacsamana, Blake Han, Mitchell Han, Stephanie White

{"title":"High-Dose Simvastatin as a Potential Trigger for Angioedema: A Case Report for Broader Diagnostic Consideration.","authors":"Jhennis Megan Lacsamana, Blake Han, Mitchell Han, Stephanie White","doi":"10.1177/23247096251381198","DOIUrl":"10.1177/23247096251381198","url":null,"abstract":"Angioedema (AE) is a potentially life-threatening condition involving swelling under the skin. The most common pharmacologic cause of this reaction is angiotensin-converting enzyme (ACE) inhibitor (ACEi) therapy, but other medications may contribute to the development of AE. This case describes a 68-year-old male who presented to the emergency department with tongue and lip swelling and was diagnosed with AE, initially attributed to lisinopril use. However, outpatient follow-up revealed that the only recent medication change was an inadvertent supratherapeutic 60 mg daily dose of simvastatin. Furthermore, the patient was found to have a medical history of AE secondary to atorvastatin use 13 years prior. Based on his history, the ACEi was discontinued, and the statin dose was reduced with symptom resolution. The patient's clinical course adds to the limited literature on statin-induced AE, particularly in the setting of concurrent ACEi use. It also underscores the importance of thorough medication reconciliation and avoiding premature diagnoses of the most common etiology.","PeriodicalId":16198,"journal":{"name":"Journal of investigative medicine high impact case reports","volume":"13 ","pages":"23247096251381198"},"PeriodicalIF":0.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12484896/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145191764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0