Journal of investigative medicine high impact case reports最新文献_第5页

Concomitant Polycythemia Vera and Primary Splenic Diffuse Large B-Cell Lymphoma Complicated by Gastrosplenic Fistula: A Case Report. 真性红细胞增多症合并原发性脾弥漫性大b细胞淋巴瘤并发胃脾瘘1例。

IF 0.9

Journal of investigative medicine high impact case reports Pub Date : 2025-01-01 Epub Date: 2025-03-17 DOI: 10.1177/23247096251325409

Bibek Saha, Jenny J Cao, Zachary S Kelm, Allison Reinhardt, Alex Danielson, Victoria Kalinoski-Dubose, William Mundell

{"title":"Concomitant Polycythemia Vera and Primary Splenic Diffuse Large B-Cell Lymphoma Complicated by Gastrosplenic Fistula: A Case Report.","authors":"Bibek Saha, Jenny J Cao, Zachary S Kelm, Allison Reinhardt, Alex Danielson, Victoria Kalinoski-Dubose, William Mundell","doi":"10.1177/23247096251325409","DOIUrl":"10.1177/23247096251325409","url":null,"abstract":"Diffuse large B-cell lymphoma (DLBCL) is the most prevalent and aggressive subtype of non-Hodgkin lymphoma comprising 30% to 40% of cases. While DLBCL frequently arises in the lymph nodes, up to 40% of cases originate in extranodal tissues. Primary splenic DLBCL is extremely rare comprising only ~1% of DLBCL cases and can be complicated by rare entities including gastrosplenic fistula (GSF). In contrast to DLBCL, polycythemia vera (PV) is a myeloproliferative malignancy. Polycythemia vera can transform into other hematologic malignancies including post-polycythemia myelofibrosis, but associations with DLBCL are uncommon. We present the first case of PV with concomitant primary splenic DLBCL complicated by GSF. While the majority of splenic lesions are benign, they have a broad differential diagnosis including malignant etiologies. Cystic or solid morphology, the number of lesions, and vascularity on imaging heavily guide further management. Due to concern for imminent massive upper gastrointestinal bleeding in the setting of GSF, our patient was diagnosed and managed with prompt splenectomy and gastrectomy. Percutaneous splenic biopsy is also a safe and effective diagnostic modality, but was deferred in our case given increased bleeding risk with PV. In conclusion, primary splenic lymphoma should be in the differential for a splenic mass regardless of whether the patient has a prior hematologic malignancy, and management should be prompt especially if complicated by a GSF.","PeriodicalId":16198,"journal":{"name":"Journal of investigative medicine high impact case reports","volume":"13 ","pages":"23247096251325409"},"PeriodicalIF":0.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11915298/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143649212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Severe Xanthogranulomatous Pyelonephritis With Staghorn Calculi and Perinephric Abscess: A Case Report. 重度黄色肉芽肿性肾盂肾炎合并鹿角型结石及肾周脓肿1例。

IF 0.9

Journal of investigative medicine high impact case reports Pub Date : 2025-01-01 Epub Date: 2025-05-14 DOI: 10.1177/23247096251342033

Manar Ashour, Ahmed Dheyaa Al-Obaidi, Shahzaib Ahmed, Nizar Alyassin, Mustafa Almusawi, Hashim Talib Hashim

引用次数: 0

A Distinctive Case of Hemophagocytic Lymphohistiocytosis in Chronic Lymphocytic Leukemia. 慢性淋巴细胞白血病中的嗜血细胞淋巴组织细胞增多症独特病例

IF 0.9

Journal of investigative medicine high impact case reports Pub Date : 2025-01-01 Epub Date: 2025-03-23 DOI: 10.1177/23247096251326465

Jayalekshmi Jayakumar, Manasa Ginjupalli, Fiqe Khan, Meher Ayyazuddin, Muhammad Ashar Ali, Giovannie Isaac Coss, Asmat Ullah

{"title":"A Distinctive Case of Hemophagocytic Lymphohistiocytosis in Chronic Lymphocytic Leukemia.","authors":"Jayalekshmi Jayakumar, Manasa Ginjupalli, Fiqe Khan, Meher Ayyazuddin, Muhammad Ashar Ali, Giovannie Isaac Coss, Asmat Ullah","doi":"10.1177/23247096251326465","DOIUrl":"10.1177/23247096251326465","url":null,"abstract":"Chronic lymphocytic leukemia (CLL) is an indolent malignancy characterized by the accumulation of dysfunctional B-cell lymphocytes. Complications such as hemophagocytic lymphohistiocytosis (HLH) can arise, particularly during disease progression. HLH has been increasingly reported as a complication of CLL, often triggered by factors such as superimposed infections, chemotherapy, Richter transformation, or disease progression. This case explores HLH as an initial presentation of undiagnosed CLL without any identifiable trigger. We present the case of a 65-year-old woman who presented with a high-grade fever, sore throat, and pancytopenia. Despite broad-spectrum antibiotic treatment, her condition deteriorated. Investigations revealed elevated ferritin levels, low natural killer cell activity, and other findings consistent with HLH. Flow cytometry and bone marrow biopsy ultimately confirmed the diagnosis of CLL. HLH is characterized by the hyperactivation of immune cells and is known to be triggered by a variety of factors, including infections and malignancies. In this case, the absence of identifiable triggers raises important questions about the underlying pathophysiology linking HLH with CLL. While previous reports have highlighted HLH as a complication of CLL, typically secondary to infection or treatment, this case is particularly noteworthy due to the unexplained onset of HLH in the absence of such triggers. This case underscores the need for heightened awareness of HLH as a potential manifestation of underlying malignancy, especially in non-septic patients presenting with unexplained fever and pancytopenia. In addition, the simultaneous presentation of normal pressure hydrocephalus emphasizes the complex interplay of inflammatory processes in CLL. Further research is needed to explore the relationship between inflammation and the pathogenesis of CLL.","PeriodicalId":16198,"journal":{"name":"Journal of investigative medicine high impact case reports","volume":"13 ","pages":"23247096251326465"},"PeriodicalIF":0.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11938485/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143692649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Friend Turned Foe: Pasteurella multocida Bacteremia Following a Scratch by an Adopted Pekin Duck. 朋友变成敌人：被收养的北京鸭子抓伤后引起的多杀性巴氏杆菌菌血症。

IF 0.9

Journal of investigative medicine high impact case reports Pub Date : 2025-01-01 Epub Date: 2025-03-20 DOI: 10.1177/23247096251326452

Lefika Bathobakae, Hannah Cho, Simi Philip, Jin S Suh

引用次数: 0

Granulomatous Polyangiitis Refractory to Induction With Rituximab in 3 Patients. 3名患者的肉芽肿性多血管炎对利妥昔单抗诱导治疗无效

IF 1.2

Journal of investigative medicine high impact case reports Pub Date : 2024-01-01 DOI: 10.1177/23247096231215730

Nouran Eshak, Grace Ehikhueme, Malvika Ramesh, John Pixley

引用次数: 0

Cocaine Gut: A Rare Case of Cocaine-Induced Esophageal, Gastric, and Small Bowel Necrosis. 可卡因肠：可卡因诱发食道、胃和小肠坏死的罕见病例。

IF 1.2

Journal of investigative medicine high impact case reports Pub Date : 2024-01-01 DOI: 10.1177/23247096241242569

Lefika Bathobakae, Sacide S Ozgur, Rammy Bashir, Tyler Wilkinson, Phenyo Phuu, Ruhin Yuridullah, Gabriel Melki, Jessica Escobar, Sohail Qayyum

{"title":"Cocaine Gut: A Rare Case of Cocaine-Induced Esophageal, Gastric, and Small Bowel Necrosis.","authors":"Lefika Bathobakae, Sacide S Ozgur, Rammy Bashir, Tyler Wilkinson, Phenyo Phuu, Ruhin Yuridullah, Gabriel Melki, Jessica Escobar, Sohail Qayyum","doi":"10.1177/23247096241242569","DOIUrl":"10.1177/23247096241242569","url":null,"abstract":"Cocaine is an indirect-acting sympathomimetic drug that inhibits norepinephrine and dopamine reuptake in the adrenergic presynaptic cleft. Cocaine use has been associated with strokes, angina, arrhythmias, and agitation. Data on gastrointestinal complications such as mesenteric ischemia, bowel necrosis, ulceration, and perforation are scarce. Here, we present a rare case of cocaine-induced esophageal, gastric, and small bowel necrosis that contributes to the limited literature on this subject. Diagnosis of cocaine-induced gastrointestinal complications involves a combination of imaging studies, laboratory assessments, and histopathological examinations. Timely surgical resection, supported by intravenous fluids, antibiotics, and pain management, is the mainstay of treatment. The prognosis varies but is significantly influenced by the promptness and effectiveness of the intervention, underscoring the importance of vigilant clinical care in such cases.","PeriodicalId":16198,"journal":{"name":"Journal of investigative medicine high impact case reports","volume":"12 ","pages":"23247096241242569"},"PeriodicalIF":1.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10981220/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140305905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Steven-Jonhson Syndrome in a Patient With Dengue Infection in Peru: A Case Report. 秘鲁登革热感染患者的 Steven-Jonhson 综合征：病例报告。

IF 1.2

Journal of investigative medicine high impact case reports Pub Date : 2024-01-01 DOI: 10.1177/23247096241242574

Winny D Aparcana-Choque, Yadira M Pisconti-Palacios, Ivan Cordova-Tello, Jhon Ausejo-Galarza, Walter Gomez-Gonzales, Andrei Kochubei-Hurtado, Kovy Arteaga-Livias

引用次数: 0

Breast Pain Differential: Mondor's Disease of the Breast. 乳房疼痛的鉴别：蒙多乳腺病

IF 1.2

Journal of investigative medicine high impact case reports Pub Date : 2024-01-01 DOI: 10.1177/23247096241246621

LaRae L Seemann, Tina Ardon, Rebecca A Bowie, Kati C Bullock, Adrianna D M Clapp

{"title":"Breast Pain Differential: Mondor's Disease of the Breast.","authors":"LaRae L Seemann, Tina Ardon, Rebecca A Bowie, Kati C Bullock, Adrianna D M Clapp","doi":"10.1177/23247096241246621","DOIUrl":"10.1177/23247096241246621","url":null,"abstract":"Breast pain is a common concern among women in primary care clinics. A rare cause of breast pain is Mondor's disease (MD), which can present as an acute, painful, erythematous, cord-like induration on the breast or anterior chest wall. The disorder is caused by sclerosing superficial thrombophlebitis of the anterolateral thoracoabdominal wall veins. There does not appear to be a racial or ethnic propensity for this condition; however, it is important to understand that it may be more difficult to see in darker skin types (Fitzpatrick skin types IV-VI) and requires close attention on physical exam. The cause of MD is poorly understood but may be related to direct trauma, strenuous exercise, or hormone changes. We review a case of a 54-year-old woman who presented with an anterior chest wall palpable cord, better visualized with adequate lighting and skin traction, ultimately diagnosed as MD based on clinical findings and imaging studies. Mondor's disease often resolves spontaneously with supportive care, as in this patient's case; however, clinicians should be aware of this rare cause of breast pain and its association with hypercoagulable state, vasculitis, and breast cancer.","PeriodicalId":16198,"journal":{"name":"Journal of investigative medicine high impact case reports","volume":"12 ","pages":"23247096241246621"},"PeriodicalIF":1.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11010737/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140866200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Unique Case of Mesenteric Gastrointestinal Stromal Tumor Presenting as an Acute Abdomen. 以急性腹部为表现的肠系膜胃肠道间质瘤的独特病例

IF 0.9

Journal of investigative medicine high impact case reports Pub Date : 2024-01-01 DOI: 10.1177/23247096241253348

Lefika Bathobakae, Rammy Bashir, Sebastian Vera, Saif Yasin, Atang Koodirile, Ratul Bhattacharyya, Mehandar Kumar

{"title":"A Unique Case of Mesenteric Gastrointestinal Stromal Tumor Presenting as an Acute Abdomen.","authors":"Lefika Bathobakae, Rammy Bashir, Sebastian Vera, Saif Yasin, Atang Koodirile, Ratul Bhattacharyya, Mehandar Kumar","doi":"10.1177/23247096241253348","DOIUrl":"10.1177/23247096241253348","url":null,"abstract":"Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors in the digestive tract and arise from the interstitial cells of Cajal in the mesenteric plexus. These tumors can originate in any part of the GI tract; however, a higher burden has been observed in the stomach and small intestines. Mesenteric GISTs are exceedingly rare, with unique clinicopathological features and a poorer prognosis. Herein, we describe a unique case of a 66-year-old female with a remote history of appendectomy who presented to the emergency room complaining of severe abdominal pain and vomiting. On imaging, the patient was found to have a large inflammatory mass associated with small bowel loops, and the pathology confirmed a mesenteric GIST. The tumor was resected, and the genomic test results confirmed the KIT (exon 11) mutation. Although the tumor had a low mitotic rate, the tumor was large enough to warrant the initiation of adjuvant imatinib mesylate for 36 months with regular bloodwork and imaging.","PeriodicalId":16198,"journal":{"name":"Journal of investigative medicine high impact case reports","volume":"12 ","pages":"23247096241253348"},"PeriodicalIF":0.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11102691/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140957705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnosis of Angioimmunoblastic T Cell Lymphoma After Receiving First Dose of Pfizer/BioNTech (BNT162b2) Vaccine: A Case Report. 首剂辉瑞/BioNTech (BNT162b2) 疫苗接种后诊断出血管免疫母细胞 T 细胞淋巴瘤：病例报告。

IF 1.2

Journal of investigative medicine high impact case reports Pub Date : 2024-01-01 DOI: 10.1177/23247096241231645

Jai Kumar Khatri, Ihab Tahboub, Khurram Anwar, Moh'd Masoudi, Vincent Graffeo, Muhammad Omer Jamil

{"title":"Diagnosis of Angioimmunoblastic T Cell Lymphoma After Receiving First Dose of Pfizer/BioNTech (BNT162b2) Vaccine: A Case Report.","authors":"Jai Kumar Khatri, Ihab Tahboub, Khurram Anwar, Moh'd Masoudi, Vincent Graffeo, Muhammad Omer Jamil","doi":"10.1177/23247096241231645","DOIUrl":"10.1177/23247096241231645","url":null,"abstract":"Pfizer/BioNTech (BNT162b2) is a messenger RNA (mRNA) vaccine that is highly effective in preventing the most severe outcomes of COVID-19 infection. Nucleoside-modified severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mRNA vaccines induce effective stimulation of T follicular helper (TFH) cells, leading to a robust germinal center B cell response. Side effects from the BNT162b2 vaccination, including significant lymphadenopathy, have been reported previously. Here, we present a case of angioimmunoblastic lymphoma (AITL), a rare, peripheral T-cell lymphoma with RHOA-G17v-mutated gene developing in a patient following BNT162B2 vaccine with a plausible explanation. A 60-year-old Asian female received her first dose of Pfizer BNT162B2 mRNA vaccine in August 2021. Right after her vaccination, she developed right axillary lymphadenopathy. She received her second vaccine dose in September 2021. Thereafter, she developed lymph node (LN) enlargement in her neck and groin. She underwent left posterior cervical and left groin LN excisional biopsy in April 2022 due to persistent palpable lymphadenopathy. Biopsy results then demonstrated benign follicular hyperplasia. For progressive B symptoms, a right axillary LN biopsy was done, which demonstrated AITL, with molecular studies revealing mutation in TET-2, IDH-2, and RHOA-G17v genes. Progression of AITL following BNT162B2 mRNA vaccine is limited in literature. Our case demonstrates a plausible correlation between the diagnosis of AITL following mRNA vaccination due to the malignant transformation of the TFH cells in patients who have a predisposing mutation of RHOA-17v. Given the rarity of AITL and the heterogeneity of molecular findings, more studies are needed to establish such an association.","PeriodicalId":16198,"journal":{"name":"Journal of investigative medicine high impact case reports","volume":"12 ","pages":"23247096241231645"},"PeriodicalIF":1.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11102676/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140957797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0