The Royal Society of Chemistry最新文献

{"title":"Dual-luminescent Sc2(MoO4)3:Dy3+/Eu3+ phosphor system: energy transfer dynamics and high-sensitivity temperature sensing","authors":"Zhengrong Xia, Rongqing Li, Fangfang Liu, Weiwei Zhou, Wang Zhao, Wei Meng, Mingjun Song and Junpeng Xue","doi":"10.1039/D5RA04860E","DOIUrl":"https://doi.org/10.1039/D5RA04860E","url":null,"abstract":"<p >A series of Dy<small>³⁺</small>/Eu<small>³⁺</small> co-doped Sc<small>₂</small>(MoO<small>₄</small>)<small>₃</small> (SMO) phosphors were synthesized <em>via</em> a conventional solid-state reaction. Phase purity and morphology were characterized by X-ray diffraction with Rietveld refinement and scanning electron microscopy, confirming the formation of phase-pure orthorhombic crystals. The electronic structure was investigated through density functional theory calculations combined with diffuse reflectance spectroscopy. Under 266 and 352 nm excitation, the Dy<small>³⁺</small> doped SMO phosphors exhibited characteristic emission peaks at 488 nm (<small>⁴</small>F<small>_9/2</small> → <small>⁶</small>H<small>_15/2</small>), 578 nm (<small>⁴</small>F<small>_9/2</small> → <small>⁶</small>H<small>_13/2</small>), 667 nm (<small>⁴</small>F<small>_9/2</small> → <small>⁶</small>H<small>_11/2</small>), and 761 nm (<small>⁴</small>F<small>_9/2</small> → <small>⁶</small>H<small>_9/2</small>). In the Dy<small>³⁺</small>/Eu<small>³⁺</small> co-doped systems, detailed analysis of spectra and luminescence decay kinetics quantitatively confirmed efficient energy transfer from Dy<small>³⁺</small> to Eu<small>³⁺</small>. Finally, the optimized SMO:Dy<small>³⁺</small>, Eu<small>³⁺</small> phosphors achieved maximum relative (<em>S</em><small>_r</small>) and absolute (<em>S</em><small>_a</small>) sensitivities of 3.817% K<small>⁻¹</small> and 0.018 K<small>⁻¹</small>, respectively, demonstrating potential for ratiometric optical thermometry applications.</p>","PeriodicalId":102,"journal":{"name":"RSC Advances","volume":" 35","pages":" 28994-29002"},"PeriodicalIF":4.6,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/ra/d5ra04860e?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144853547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Natural tricyclic and hyper-polycyclic aromatic hydrocarbons: structure, biosynthesis, bioactivity, and synthesis.","authors":"Yujian Mao, Xiaoting Song, Weiwei Xu, Hanghang Wang, Junkai You, Jialin Liu, Xuan Ye, Yinan Zhang","doi":"10.1039/d5np00032g","DOIUrl":"https://doi.org/10.1039/d5np00032g","url":null,"abstract":"<p><p>Covering: 1950 to up to the end of 2024Natural products containing polycyclic aromatic hydrocarbons (PAHs) feature at least two fused aromatic ring systems, conforming to Hückel's rule and representing an important class of secondary metabolites with a wide range of biological activities. Among them, the subtype of natural products containing tricyclic and greater than tricyclic systems has been neglected for a long time. This review summarizes the isolation, structural features, bioactivities, biosynthetic pathways, and chemical synthesis of this special subtype reported over the past decades. This review provides a current understanding of the tricyclic and hyper-PAHs represented by anthracene, phenanthrene, acenaphthalene, pyrene, fluoranthene, and tetraphene from organic, biosynthetic, and pharmacological perspectives.</p>","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":" ","pages":""},"PeriodicalIF":10.6,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144854034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patterns with long and short-range order in monoloyers of binary mixtures with competing interactions.","authors":"M Litniewski, W T Gozdz, A Ciach","doi":"10.1039/d5sm00543d","DOIUrl":"https://doi.org/10.1039/d5sm00543d","url":null,"abstract":"<p><p>Lateral microsegregation in a monolayer of a binary mixture of particles or macromolecules is studied by molecular dynamics simulations in a generic model with the interacting potentials inspired by effective interactions in biological or soft-matter systems. In the model, the energy is minimized when like particles form small clusters, and the cross-interaction is of opposite sign. We show that the laterally microsegregated components in the dense ordered phases form alternating stripes for similar densities, or the clusters of the minority component fill the hexagonally distributed voids formed in the dense phase of the majority component. A qualitative phase diagram in the plane of densities of the two components is constructed for low temperatures. An addition of the second component significantly enlarges the temperature range of the stability of the ordered phases compared to the stability of these phases in the one-component system. At higher temperatures, the disordered phase consisting of individual particles, one-component clusters and two-component super-clusters of various sizes is stable. The product <i>kn</i>(<i>k</i>), with <i>n</i>(<i>k</i>) denoting the average number of super-clusters composed of <i>k</i> particles, decays exponentially with <i>k</i>, and the inverse decay rate depends linearly on temperature.</p>","PeriodicalId":103,"journal":{"name":"Soft Matter","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144854052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Carbon nanomaterials as smart interfaces in ultrathin films for high-performance electrochemical sensors: a critical review","authors":"Monika Poonia and Amar Singh","doi":"10.1039/D5RA04565G","DOIUrl":"https://doi.org/10.1039/D5RA04565G","url":null,"abstract":"<p >Carbon nanomaterials (CNMs) have emerged as pivotal components in the evolution of electrochemical sensors (ECSs), owing to their exceptional electrical conductivity, biocompatibility, and versatility across various analytical applications. Recent advancements in nanoengineered thin films of CNMs have yielded robust electrochemical sensing systems with enhanced analytical capabilities. This review article offers a detailed analysis of the use of nano-engineered CNMs thin films, with a particular focus on layer-by-layer assembly, Langmuir–Blodgett, and Langmuir–Schaefer deposition techniques for the development of high-performance ECSs. By presenting a holistic overview of the field, this article explores the diverse CNMs employed in ECS development, examining their synthesis and the ongoing quest to optimize material properties for enhanced sensor performance and technological advancement. It highlights the remarkable electrochemical properties of CNMs and their significant potential in the sensitive and selective detection of a wide array of substances, including chemicals, pharmaceutical compounds, biological analytes, environmental pollutants, and gases. This review summarizes the current status and future potential of nano-engineered CNM thin films in electrochemical sensing applications. Additionally, it highlights the need for further research to address challenges related to thin film stability, reproducibility, and material selectivity for sensing applications at the intersection of nanotechnology and electrochemical sensing.</p>","PeriodicalId":102,"journal":{"name":"RSC Advances","volume":" 35","pages":" 28897-28917"},"PeriodicalIF":4.6,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/ra/d5ra04565g?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144853542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel nano-trapping matrix for enrichment and analysis of crotonaldehyde in smoker saliva.","authors":"Dawei Qi, Jia Qi, Huaqing Lin, Xufang Hu, Chunhui Deng","doi":"10.1039/d5ay00990a","DOIUrl":"https://doi.org/10.1039/d5ay00990a","url":null,"abstract":"<p><p>Crotonaldehyde is a harmful ingredient in cigarette smoke and poses serious health risks due to irritation of the mucous membranes and systemic toxicity, which are associated with respiratory illnesses and cancer. Thus, developing rapid detection methods for crotonaldehyde levels in biofluids is essential for effective monitoring and management. In this work, we designed a novel nano-trapping matrix for the sensitive analysis of crotonaldehyde in saliva. This nano-trapping matrix is constructed by assembling a platinum inlaid metal-organic framework (MOF) shell on a magnetic Fe₃O₄ core through a simple one-pot process and serves a dual purpose as follows. One function is as an efficient nano-trapper for enriching target analytes <i>via</i> π-π interactions, thereby reducing matrix interference. Another function is serving as an effective matrix for direct matrix-assisted laser desorption/ionization mass spectrometry (MALDI MS) detection. This function leverages the synergistic properties of the π-electron system in MOFs and the conductivity and high UV absorption of Fe₃O₄, along with the photoelectric abilities of Pt nanoparticles to improve ionization efficiency and enhance MS signal intensity. Thus, the traditional elution process was avoided and a simple yet sensitive analytical method was established, achieving a detection limit of 1 ng mL^-1. The method demonstrated good applicability by successfully capturing and detecting crotonaldehyde from saliva samples of three smokers, including one cigarette user and two e-cigarette users. Our approach offers an effective analytical tool for crotonaldehyde biomonitoring and provides a referenceable design strategy for integrated nanomaterials for the capture and direct analysis of small molecules.</p>","PeriodicalId":64,"journal":{"name":"Analytical Methods","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144853956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prepared polypropylene microplastics: formation of eco-corona in aquatic systems and their combined toxicity with cadmium in <i>Artemia franciscana</i>.","authors":"Anna Sundar Sarmila, Natarajan Chandrasekaran","doi":"10.1039/d5em00260e","DOIUrl":"https://doi.org/10.1039/d5em00260e","url":null,"abstract":"<p><p>Our study investigated the interactions between colloids present in various aquatic environments and the surface of microplastics (MPs), with a specific focus on their behavior in tap water, lake water and marine water systems. This phenomenon is commonly referred to as \"eco-corona\". Polypropylene microplastics, although extensively utilized in various applications, have been less studied than polystyrene and polyethylene microplastics. The prepared polypropylene microplastics were characterized by ATR-FTIR and Raman spectroscopy, and the formation of eco-corona was monitored at specific time intervals (24, 48, 72, 96 and 120 h). Fluorescence spectroscopy was used to measure the corresponding fluorescence intensity. Further investigations through FTIR spectroscopy revealed a reduction or complete disappearance of the characteristic polymer peaks upon suspension in natural water systems. Eco-coronated MPs exhibit more cadmium adsorption than raw MPs. The combined exposure of eco-coronated MPs and cadmium to the brine shrimp <i>Artemia</i> leads to the bioaccumulation of microplastics. At its peak concentration (0.5 mg mL^-1), both weathered and true-to-life microplastics significantly increased reactive oxygen species production (<i>p</i> < 0.001) in a concentration-dependent manner. Similarly, superoxide dismutase activity increased in a dose-dependent manner, with weathered microplastics showing significant elevation (<i>p</i> < 0.001). Conversely, total protein content was reduced at higher concentrations of both weathered and true-to-life microplastics. The interaction between microplastics and biomolecules/colloids diminishes their presence in the environment, acts as a vector for pollutants, and mimics food for aquatic organisms. Additionally, it facilitates bioaccumulation in lower-to-higher aquatic organisms and contributes to the collapse of the food web.</p>","PeriodicalId":74,"journal":{"name":"Environmental Science: Processes & Impacts","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144853970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genome mining reveals a highly oxidized bacterial perhydrophenanthrene meroterpenoid smelanic acid.","authors":"Ziyi Yang, Xingming Pan, Lianchun Deng, Zengyuan Wang, Fang-Ru Li, Xiaoxu Lin, Hui-Min Xu, Liao-Bin Dong","doi":"10.1039/d5ob01195g","DOIUrl":"https://doi.org/10.1039/d5ob01195g","url":null,"abstract":"<p><p>Bacterial perhydrophenanthrene meroterpenoids are rare natural products featuring highly oxidized 6/6/6 fused tricyclic scaffolds. Using our previously characterized non-canonical terpene cyclase AtoE as a guide, we conducted targeted genome mining and identified a cryptic biosynthetic gene cluster in <i>Streptomyces melanosporofaciens</i> containing SmeD, an AtoE homolog with 46.15% sequence identity. Heterologous expression of the core gene cluster in <i>Streptomyces albus</i> J1074 led to the production of smelanic acid (1), whose structure was elucidated by NMR spectroscopy and X-ray crystallography. Compound 1 features a perhydrophenanthrene core with a highly oxidized side chain containing both an epoxide and a glycolic acid moiety, representing a unique oxidation pattern among bacterial meroterpenoids. This work demonstrates the effectiveness of enzyme-guided genome mining for discovering structurally novel natural products and expands the chemical diversity of bacterial meroterpenoids.</p>","PeriodicalId":96,"journal":{"name":"Organic & Biomolecular Chemistry","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144854038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Iodine-mediated synthesis of indole-fused benzothiazepinones through intramolecular C2-amidation of amide-tethered C3-sulfenylindoles.","authors":"Gargi Singh, Mariyaraj Arockiaraj, Venkatachalam Rajeshkumar","doi":"10.1039/d5ob00842e","DOIUrl":"https://doi.org/10.1039/d5ob00842e","url":null,"abstract":"<p><p>A transition-metal-free, iodine-mediated strategy has been developed for the synthesis of biologically significant indole-fused benzothiazepinones. This method involves an initial electrophilic C3 iodination of indole, followed by intramolecular C2 amidation of readily accessible amide-tethered C3-sulfenylindoles to afford indole-fused benzothiazepinones in good yields. The protocol exhibits broad substrate compatibility, high functional group tolerance, and scalability. Additionally, the synthetic versatility of the resulting indole-fused benzothiazepinones was demonstrated through their transformation into the corresponding sulfoxides and sulfones.</p>","PeriodicalId":96,"journal":{"name":"Organic & Biomolecular Chemistry","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144854039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel self-assembled metal-phenolic nanoplatforms for triple-negative breast cancer treatment: photothermal-chemotherapy/ferroptosis synergy inducing immunogenic cell death","authors":"Bohao Peng, Ruoyao Wang, Tian Li, Xiaoqing Yu, Zhiyu Wang, Xiyang Zhang, Yuanfeng Tan, Long Cheng and Lu Yang","doi":"10.1039/D5RA03962B","DOIUrl":"https://doi.org/10.1039/D5RA03962B","url":null,"abstract":"<p >Triple-negative breast cancer (TNBC) poses a serious threat to women's health. Currently, chemotherapy remains the first-line treatment in the clinic, and more comprehensive treatments are urgently needed to improve the therapeutic efficacy of TNBC. Emerging studies have indicated that photothermal therapy, ferroptosis and immunotherapy also play crucial roles in TNBC treatment. Iron based metal-phenolic networks (MPNs), an emerging class of nanomaterials, are attracting great attention in tumor related research due to their unique structural features. These features endow MPNs with outstanding catalytic efficiency for the Fenton reaction and excellent metal–ligand conversion properties, offering promising prospects for photothermal and photodynamic therapies as well as combined treatment strategies for tumors. In this study, a novel iron-based metal-phenolic nanoplatform, namely MTO-loaded TA/Fe nanocomposites (MFTA), was synthesized. Mitoxantrone (MTO), a commonly used anthracycline, was employed along with ferric chloride (FeCl<small>₃</small>) and tannic acid (TA) in the synthesis process. Firstly, TA and FeCl<small>₃</small>, two non-photosensitive substances, underwent a coordination reaction to form a blue-black compound TAF, which exhibited ideal photosensitivity. Secondly, through π–π interactions, TAF and MTO partially quenched the autofluorescence of MTO, leading to a cascade amplification of photothermal conversion in the self-assembled nanoplatforms. The myocardial-protective effect of TA enhanced the safety of MTO-based chemotherapy. Additionally, FeCl<small>₃</small> was partially reduced to ferrous ion (Fe<small>²⁺</small>) by TA, and the introduction of a large amount of Fe<small>²⁺</small> could trigger ferroptosis in TNBC. Moreover, the induction of immunogenic cell death in TNBC cells, which was stimulated by photothermal therapy, chemotherapy and ferroptosis, further enhanced the synergistic effect. Finally, this nanoplatform may help improve real-time photoacoustic imaging and assist in treatment monitoring. In summary, the developed nanoplatform offers a novel strategy for the comprehensive treatment of TNBC, holding certain potential for clinical translation.</p>","PeriodicalId":102,"journal":{"name":"RSC Advances","volume":" 35","pages":" 28965-28983"},"PeriodicalIF":4.6,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/ra/d5ra03962b?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144853545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of hair follicle spheroids with growth factor transfection and various cell combinations.","authors":"Hyeon-Min Nam, Subin Jeong, Gun Yong Sung","doi":"10.1039/d5bm00998g","DOIUrl":"https://doi.org/10.1039/d5bm00998g","url":null,"abstract":"<p><p>As the number of hair loss patients increases, research conducted on hair follicles and hair has recently become more active. However, most current hair follicle research models are limited in their ability to reproduce several key functions of the hair follicle microenvironment. To solve this problem, hair growth genes were injected into hair follicle cells, and long-term culture was performed for up to 90 days. DPCs (dermal papilla cells), KCs (keratinocytes), HUVECs (human umbilical vein endothelial cells) or HDMECs (human dermal microvascular endothelial cells), and FBs (fibroblasts) injected with hair follicle growth factors LEF1 and Wnt1 were mixed to produce spheroids, and the growth factor expression and growth behavior according to the type of cell and the presence or absence of transfection according to the culture period were analyzed using SEM, H&E staining, and IF imaging. As the culture period increased, the size of the spheroids increased, and the number decreased due to the association between spheroids; long fibers that appeared to be hair expression were observed. We also compared the differences between HUVECs and HDMECs, which have different phenotypes of vascular cells. In spheroids that did not contain FBs, the expression of HUVECs was more promoted, whereas in spheroids that contained FBs, the expression of HDMECs tended to be more promoted. These results are expected to contribute to dermatology and new drug development for the prevention of intractable skin diseases and hair loss using skin models with a microbiome environment in the future.</p>","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144853966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}