The Royal Society of Chemistry最新文献

{"title":"The kinetics of a light irradiation enhanced room temperature NO2 gas sensor using hybrid ZnO/ZnTe nanorod structures†","authors":"Nguyen Minh Hieu, Cao Van Phuoc, Cao Viet Anh, Nguyen Manh Hung, Anh D. Phan, Nguyen Duc Chinh, Sutripto Majumder, Truong Hong Cuong, Hoang Gia Chuc, Do Van Minh, Do Quang Trung, Tu Nguyen, Nguyen Van Du, Tran Manh Trung, Pham Thanh Huy, Jong-Ryul Jeong, Chunjoong Kim and Dojin Kim","doi":"10.1039/D4RA06969B","DOIUrl":"https://doi.org/10.1039/D4RA06969B","url":null,"abstract":"<p >This study focuses on fabricating a hybrid structure consisting of ZnO nanorods and ZnTe nanoparticles for NO<small>₂</small> gas detection, particularly exploring the impact of light irradiation at room temperature (RT). The morphology, physical characteristics, and chemical properties of the ZnO/ZnTe hybrid structure are carefully studied under diverse analytical methods such as X-ray diffraction (XRD), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), and other measurements. The ZnO/ZnTe composite displayed an improved response toward 500 ppb NO<small>₂</small> under the blue light radiation effect. It demonstrated higher response (more than 2500%), response time (faster than 3000%), and recovery time (faster than 1000%) at RT compared with pure ZnO. Hence, blue light irradiation revealed a more promising sensing performance than UV irradiation's case (200% at sensitivity). The depletion theory, the oxygen vacancy, the catalytic effect of zinc telluride, and the absorption coefficient modulation of the gas sensor based on different materials explained the overall performance of the nanohybrid structured sensor.</p>","PeriodicalId":102,"journal":{"name":"RSC Advances","volume":" 53","pages":" 39418-39428"},"PeriodicalIF":3.9,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2024/ra/d4ra06969b?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142810769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis of novel pyridine and pyrazolyl pyridine conjugates with potent cytotoxicity against HepG2 cancer cells as PIM-1 kinase inhibitors and caspase activators†","authors":"Mohamed S. Nafie, Ahmed Hamza, Ahmed H. Moustafa, Hassan A. El-Sayed, Samir M. El Rayes, Hesham A. Morsy and Ahmed Aboelmaged","doi":"10.1039/D4RA07963A","DOIUrl":"https://doi.org/10.1039/D4RA07963A","url":null,"abstract":"<p >A novel series of nicotinonitrile and pyrazolyl nicotinonitrile were synthesized, and their PIM-1 kinase inhibitors and caspase activators were investigated. New Manich bases <strong>6–8</strong> were synthesized <em>via</em> reaction of pyridine <strong>4</strong> with piperidine, dimethyl amine, and morpholine in the presence of formalin. On the other hand, the pyrazolyl analogues <strong>10–12</strong> were synthesized <em>via</em> heterocyclization of acetohydrazide derivative <strong>9</strong> with acetylacetone, malononitrile, and ethyl cyanoacetate, respectively, in ethanol. The cytotoxic activity of compound <strong>9</strong> against MCF-7 and HepG2 cells was particularly noteworthy, with IC<small>₅₀</small> values of 0.34 μM and 0.18 μM, respectively, among these derivatives. Compared to staurosporine with potent PIM-1 kinase inhibition, which had an IC<small>₅₀</small> value of 16.7 nM and an inhibition of 95.6%, compound <strong>9</strong> had a strong inhibitory effect, with IC<small>₅₀</small> values of 20.4 nM and 93.8%. It induced apoptosis activity in HepG2 cancer cells. Accordingly, compound <strong>9</strong> was proven to be an effective chemotherapeutic drug that targets PIM-1 in treating liver cancer.</p>","PeriodicalId":102,"journal":{"name":"RSC Advances","volume":" 53","pages":" 39381-39394"},"PeriodicalIF":3.9,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2024/ra/d4ra07963a?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142810766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mild decarboxylation of neat muconic acid to levulinic acid: a combined experimental and computational mechanistic study†","authors":"Siddhant Bhardwaj, Deep M. Patel, Michael J. Forrester, Luke T. Roling and Eric W. Cochran","doi":"10.1039/D4RA05226A","DOIUrl":"https://doi.org/10.1039/D4RA05226A","url":null,"abstract":"<p >Levulinic acid (LA) is a key platform molecule with current applications in the synthesis of several commodity chemicals, including amino-levulinic acid, succinic acid, and valerolactone. In contrast to existing petroleum-based synthesis pathway, biomass-derived <em>cis</em>–<em>cis</em>-muconic acid (MA) offers a sustainable route to synthesize LA. Here, we show the complete decarboxylation of neat MA to LA without solvent at atmospheric pressure and mild temperature. In a series of sulfuric acid catalyzed experiments, we used a suite of one and two-dimensional NMR techniques along with gas chromatography-mass spectrometry (GCMS) analysis and density functional theory (DFT) calculations to elucidate the intermediates involved in LA synthesis. Experimental kinetic studies revealed rate constants for the consumption of MA and the formation of LA, with activation energies calculated to be 16.10 kJ mol<small>⁻¹</small> and 158.18 kJ mol<small>⁻¹</small>, respectively.</p>","PeriodicalId":102,"journal":{"name":"RSC Advances","volume":" 53","pages":" 39408-39417"},"PeriodicalIF":3.9,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2024/ra/d4ra05226a?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142810768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-pressure band-gap engineering and structural properties of van der Waals BiOCl nanosheets†","authors":"Yaqian Dan, Meiyan Ye, Weiwei Dong, Yihang Yao, Min Lian, Mingyang Du, Shuailing Ma, Xiaodong Li and Tian Cui","doi":"10.1039/D4RA07692C","DOIUrl":"https://doi.org/10.1039/D4RA07692C","url":null,"abstract":"<p >van der Waals BiOCl semiconductors have gained significant attention due to their excellent photochemical catalysis, low-cost and non-toxicity. However, their intrinsic wide band gap limits visible light utilization. This study explores high-pressure band-gap engineering, a “chemical clean” method, to optimize BiOCl's electronic structure. Utilizing <em>in situ</em> high-pressure ultraviolet-visible (UV-vis) absorption spectra, Raman spectroscopy and XRD, we systematically investigate the effects of compression on band gap and crystal structure evolution of BiOCl. Our results demonstrate that pressure efficiently narrows the band gap from 3.44 eV to 2.81 eV within the pressure range of 0.4–44 GPa. The further Raman and XRD analyses reveal an isostructural phase transition, leading to a significant change in the compressibility of the lattice parameters and bonds from anisotropic to isotropic. These findings provide a potential pathway to tune the bandgap for enhancing the photocatalytic efficiency of BiOCl.</p>","PeriodicalId":102,"journal":{"name":"RSC Advances","volume":" 53","pages":" 39429-39435"},"PeriodicalIF":3.9,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2024/ra/d4ra07692c?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142810770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A short review of the sustainable utilization of coal gangue in environmental applications","authors":"Lihui Gao, Yanhong Liu, Keyi Xu, Lu Bai, Nan Guo and Shulei Li","doi":"10.1039/D4RA06071G","DOIUrl":"https://doi.org/10.1039/D4RA06071G","url":null,"abstract":"<p >The production of coal gangue, a by-product of coal mining and washing, is rapidly increasing due to growing energy consumption. As the accumulated coal gangue has not been appropriately utilized, this has resulted in a squander of resources, waste disposal problems, and environmental pollution issues. However, coal gangue, a form of solid waste, exhibits various potential applications in the field of recycling. Currently, the processing capacity and utilization rate of coal gangue are insufficient to meet the demands of global low-carbon environmental protection. As such, this paper provides a detailed overview of the physical and chemical properties of coal gangue and its resource utilization methods in the environmental field, particularly in soil remediation, soil reclamation, the preparation of adsorbents for heavy metals, dyes, and CO<small>₂</small>, and as catalysts for organic degradation and catalytic cracking. This review highlights the significance of coal gangue classification according to its properties for the comprehensive utilization of gangue. Additionally, we briefly introduce and discuss suggestions for future directions of research and development in this area. Nevertheless, with regard to the environmental impact of secondary pollution and the efficiency of coal gangue utilization, there remain numerous obstacles that hinder future research. This review is expected to provide significant insights into the development of coal gangue utilization strategies, potentially facilitating the efficient and practical large-scale management of solid waste.</p>","PeriodicalId":102,"journal":{"name":"RSC Advances","volume":" 53","pages":" 39285-39296"},"PeriodicalIF":3.9,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2024/ra/d4ra06071g?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142810778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cancer treatment approaches within the frame of hyperthermia, drug delivery systems, and biosensors: concepts and future potentials","authors":"Zeinab S. Sayed, Eman M. Hieba, Hany A. Batakoushy, Huda R. M. Rashdan, Enas Ismail, Saeid M. Elkatlawy and Amir Elzwawy","doi":"10.1039/D4RA06992G","DOIUrl":"https://doi.org/10.1039/D4RA06992G","url":null,"abstract":"<p >This work presents a review of the therapeutic modalities and approaches for cancer treatment. A brief overview of the traditional treatment routes is presented in the introduction together with their reported side effects. A combination of the traditional approaches was reported to demonstrate an effective therapy until a few decades ago. With the improvement in the fabrication of nanomaterials, targeted therapy represents a novel therapeutic approach. This improvement established on nanoparticles is categorized into hyperthermia, drug delivery systems, and biosensors. Hyperthermia presents a personalized medicine-based approach in which targeted zones are heated up until the diseased tissue is destroyed by the thermal effect. The use of magnetic nanoparticles further improved the effectiveness of hyperthermia owing to the enhanced heating action, further increasing the accuracy of the targeting process. Nanoparticle-based biosensors present a smart nanodevice that can detect, monitor, and target tumor tissues by following the biomarkers in the body fluids. Magnetic nanoparticles offer a controlled thermo-responsive device that can be manipulated by changing the magnetic field, offering a more personalized and controlled hyperthermia therapeutic modality. Similarly, gold nanoparticles offer an effective aid in the hyperthermia treatment approach. Furthermore, carbon nanotubes and metal–organic frameworks present a cutting-edge approach to cancer treatment. A combination of functionalized nanoparticles offers a unique route for drug delivery systems, in which therapeutic agents carried by nanoparticles are guided into the human body and then released in the target spot.</p>","PeriodicalId":102,"journal":{"name":"RSC Advances","volume":" 53","pages":" 39297-39324"},"PeriodicalIF":3.9,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2024/ra/d4ra06992g?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142810779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electrochemical reduction method for leaching terbium and cerium from waste phosphors†","authors":"Ruixiang Wang, Piao Xu, Boyi Xie, Chaxiang Liu, Xiaocong Zhong, Zhongtang Zhang and Helin Fan","doi":"10.1039/D4RA06334A","DOIUrl":"https://doi.org/10.1039/D4RA06334A","url":null,"abstract":"<p >Rare earth elements are commonly used in various fields due to their unique physical and chemical properties. Waste phosphors represent an important secondary source of rare earth elements, and their recovery is a crucial means of improving the utilization of these resources. When using FeCl<small>₂</small> as a reducing agent to reduce Tb<small>⁴⁺</small> and Ce<small>⁴⁺</small> from washed phosphors, a large amount of reducing agent is required, and the Fe<small>²⁺</small> cycle becomes complicated. In this study, the electrochemical reduction process was employed to treat washed phosphors. Under optimum conditions of FeCl<small>₂</small> concentration of 0.10 mol L<small>⁻¹</small>, current density of 100 A m<small>⁻²</small>, HCl concentration of 3 mol L<small>⁻¹</small>, temperature of 80 °C, L/S ratio of 30 mL g<small>⁻¹</small>, and time of 60 min, the leaching efficiencies of Tb and Ce reached 99.2% and 98.5%, respectively. The apparent activation energies of Tb and Ce were calculated as 17.71 and 18.46 kJ mol<small>⁻¹</small>, respectively, illustrating that the leaching processes of Tb and Ce depend on the diffusion. By applying an external electric field, Fe<small>²⁺</small> can be recycled in the system, thereby reducing the amount of reducing agent needed and achieving a higher leaching efficiency for Tb and Ce. These results are beneficial for the resource utilization of waste phosphors and have significant implications for the sustainable development of rare earth resources.</p>","PeriodicalId":102,"journal":{"name":"RSC Advances","volume":" 53","pages":" 39353-39360"},"PeriodicalIF":3.9,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2024/ra/d4ra06334a?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142810782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Controlled tuning of HOMO and LUMO levels in supramolecular nano-Saturn complexes†","authors":"Maria Maqbool and Khurshid Ayub","doi":"10.1039/D4RA07068B","DOIUrl":"https://doi.org/10.1039/D4RA07068B","url":null,"abstract":"<p >Optoelectronics usually deals with the fabrication of devices that can interconvert light and electrical energy using semiconductors. The modification of electronic properties is crucial in the field of optoelectronics. The tuning of the highest occupied molecular orbital (HOMO) and lowest unoccupied molecular orbital (LUMO) and their energy gaps is of paramount interest in this domain. Herein, three nano-Saturn supramolecular complex systems are designed, <em>i.e.</em>, Al<small>₁₂</small>N<small>₁₂</small>@S-belt, Mg<small>₁₂</small>O<small>₁₂</small>@S-belt, and B<small>₁₂</small>P<small>₁₂</small>@S-belt, using S-belt as the host and Al<small>₁₂</small>N<small>₁₂</small>, Mg<small>₁₂</small>O<small>₁₂</small>, and B<small>₁₂</small>P<small>₁₂</small> nanocages as guests. The high interaction energies ranging from −22.03 to −63.64 kcal mol<small>⁻¹</small> for the complexes demonstrate the stability of these host–guest complexes. Frontier molecular orbital (FMO) analysis shows that the HOMO of the complexes originates from the HOMO of the host, and the LUMO of the complexes originate entirely from the LUMO of the guests. The partial density of states (PDOS) analysis is in corroboration with FMO, which provides graphical illustration of the origin of HOMO and LUMO levels and the energy gaps. The shift in the electron density upon complexation is demonstrated by the natural bond orbital (NBO) charge analysis. For the Al<small>₁₂</small>N<small>₁₂</small>@S-belt and B<small>₁₂</small>P<small>₁₂</small>@S-belt complexes, the direction of electron density shift is towards the guest species, as indicated by the overall negative charge on encapsulated Al<small>₁₂</small>N<small>₁₂</small> and B<small>₁₂</small>P<small>₁₂</small>. For the Mg<small>₁₂</small>O<small>₁₂</small>@S-belt complex, the overall NBO charge is positive, elaborating the direction of overall shift of electronic density towards the S-belt. Electron density difference (EDD) analysis verifies and corroborates with these findings. Noncovalent interaction index (NCI) and quantum theory of atoms in molecules (QTAIM) analyses signify that the complexes are stabilized <em>via</em> van der Waals interactions. Absorption analysis explains that all the complexes absorb in the ultraviolet (UV) region. Overall, this study explains the formation of stable host–guest supramolecular nano-Saturn complexes along with the controlled tuning of HOMO and LUMO levels over the host and guests, respectively.</p>","PeriodicalId":102,"journal":{"name":"RSC Advances","volume":" 53","pages":" 39395-39407"},"PeriodicalIF":3.9,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2024/ra/d4ra07068b?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142810767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rhodium-catalyzed transformations of diazo compounds via a carbene-based strategy: recent advances","authors":"Fatemeh Doraghi, Parsa Baghershahi, Mehran Ghasemi, Mohammad Mahdavi and Ahmed Al-Harrasi","doi":"10.1039/D4RA07010K","DOIUrl":"https://doi.org/10.1039/D4RA07010K","url":null,"abstract":"<p >Diazo compounds are known to be good coupling partners in the synthesis of heterocycles, carbocycles and functionalized molecules <em>via</em> a rhodium carbene-based strategy. Many heterocyclic and carbocyclic compounds, including isoquinolones and isocoumarins, quinoxalines, indoles, pyrrones, benzothazines, enaminones, benzenes and seven-membered rings, can be constructed using this rhodium-catalyzed system. The reaction mechanism involves C–H activation, carbene insertion and an annulation/functionalization sequence. This review describes the progress made in the last five years in rhodium-catalyzed transformations of diazo compounds as easily accessible precursors in organic chemistry.</p>","PeriodicalId":102,"journal":{"name":"RSC Advances","volume":" 53","pages":" 39337-39352"},"PeriodicalIF":3.9,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2024/ra/d4ra07010k?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142810781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Isocyanate-based multicomponent reactions","authors":"Clara Zavarise, Jean-Christophe Cintrat, Eugénie Romero and Antoine Sallustrau","doi":"10.1039/D4RA04152F","DOIUrl":"https://doi.org/10.1039/D4RA04152F","url":null,"abstract":"<p >Since their discovery, multicomponent reactions have attracted significant attention due to their versatility and efficiency. This review aims to explore the latest advancements in isocyanate-based multicomponent reactions and the sophisticated chemical opportunities they present for generating molecules of interest. The added value of the methodologies described, supported by mechanism schemes, as well as scopes of application, will be discussed. These developments will be organised as the main accessible chemical functions and sorted according to their type of MCR (3, 4 or 5-MCR).</p>","PeriodicalId":102,"journal":{"name":"RSC Advances","volume":" 53","pages":" 39253-39267"},"PeriodicalIF":3.9,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2024/ra/d4ra04152f?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142810772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}