The Royal Society of Chemistry最新文献

{"title":"Numerical investigation on the dynamic behavior of bubbles under forced flow in a microchannel†","authors":"Dayong Li, Junbo Xing, Ziqun Zhang and Hongfei Wang","doi":"10.1039/D5RA02116B","DOIUrl":"https://doi.org/10.1039/D5RA02116B","url":null,"abstract":"<p >Understanding the process of bubble detachment and motion along microchannel walls, driven by liquid flow, is crucial for elucidating bubble dynamics and realizing diverse applications within the realm of microfluidics. This paper uses the phase-field method to perform a comprehensive numerical study on the conversion of surface gas bubbles into bulk bubbles at the lower wall of a microfluidic channel. The study identifies several key factors that have a coupled impact on the ‘surface-bulk’ conversion, including wall wettability, Reynolds number, and the initial contact angle/volume of the surface bubbles (with contact angle and volume positively correlated at a fixed base radius). Specifically, higher Reynolds numbers, smaller initial bubble contact angles, and more hydrophilic channel walls facilitate the detachment of surface bubbles from the channel wall. However, at high Reynolds numbers, bubbles on superhydrophilic surfaces may be split, causing fluctuations or longer conversion time. Conversely, as wall hydrophobicity increases, surface bubbles remain attached.</p>","PeriodicalId":102,"journal":{"name":"RSC Advances","volume":" 29","pages":" 23414-23426"},"PeriodicalIF":3.9,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/ra/d5ra02116b?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144573143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis of C60-CM-Cn and its effect on the stabilization of nitrocellulose†","authors":"Haoxi Chu, Bo Jin, Yang Zhao and Rufang Peng","doi":"10.1039/D5RA01741F","DOIUrl":"https://doi.org/10.1039/D5RA01741F","url":null,"abstract":"<p >The fullerene derivative C<small>₆₀</small>-CM-C<small>_<em>n</em></small> was synthesized <em>via</em> a two-step reaction using fullerene (C<small>₆₀</small>), curcumin (C<small>₂₁</small>H<small>₁₈</small>O<small>₅</small>), and bromoalkanes (RBr) as raw materials. The structure of C<small>₆₀</small>-CM-C<small>_<em>n</em></small> was characterized by nuclear magnetic resonance (<small>¹</small>H and <small>¹³</small>C NMR) and high-resolution mass spectrometry (HR MS). Thermal analysis, including differential thermal analysis (DTA), vacuum stability tests (VST), thermogravimetric analysis (TG), and methyl violet experiments, along with electron paramagnetic resonance spectroscopy, was used to investigate the interaction mechanism between C<small>₆₀</small>-CM-C<small>_<em>n</em></small> and nitrocellulose (NC). The results demonstrated that there is good compatibility between C<small>₆₀</small>-CM-C<small>_<em>n</em></small> and NC, C<small>₆₀</small>-CM-C<small>_<em>n</em></small> extended the color change time of methyl violet paper by 28–47 min, reduced the gas released during the thermal decomposition of NC by 0.7–1.69 mL g<small>⁻¹</small>, and decreased the heat loss rate of NC by 9.8–15.6%. Additionally, at a minimum concentration of 0.19 g L<small>⁻¹</small>, C<small>₆₀</small>-CM-C<small>_<em>n</em></small> achieved a 50% removal rate of nitrogen oxides (NO<small>_<em>x</em></small>). These findings indicate that C<small>₆₀</small>-CM-C<small>_<em>n</em></small> serves as an effective antioxidant for the removal of nitrogen oxides from NC fibers, outperforming traditional stabilizers such as diphenylamine (DPA) and C2 in improving NC stability.</p>","PeriodicalId":102,"journal":{"name":"RSC Advances","volume":" 29","pages":" 23827-23835"},"PeriodicalIF":3.9,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/ra/d5ra01741f?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144581783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioanalytical method development and validation for determination of olutasidenib and its application to pharmacokinetic studies","authors":"Madhusudhana Reddy Nimmakayala, Kuruva Rangamuni, Jasti Surendra, Jatla Murali Prakash and Deepti Kolli","doi":"10.1039/D5RA01161B","DOIUrl":"https://doi.org/10.1039/D5RA01161B","url":null,"abstract":"<p >Olutasidenib is an inhibitor licensed by the FDA, indicated against mutations in isocitrate dehydrogenase-1 (IDH1). For individuals with vulnerable IDH1 mutations, it has been demonstrated to be a very effective therapy for recurrent or refractory acute myeloid leukemia (AML). After a long review procedure, olutasidenib was finally given an approval by the FDA in December of 2022. To determine the concentration of olutasidenib in rat plasma, an LC-MS/MS approach was applied. The drug ibrutinib serves as a standard for comparison. Inertsil ODS, 150 mm × 4.6 mm, 3.5 μm, mobile phase was Acetonitrile (ACN), and Ammonium formate buffer (AmF), pH 3.0 (50 : 50 v/v) at 1.0 ml min<small>⁻¹</small> was used for the separation process. Liquid–liquid extraction (LLE) was adopted for both olutasidenib and the Internal standard (IS). Proton adducts of olutasidenib and ibrutinib were observed at <em>m</em>/<em>z</em> 354.8589 and 239.8107 and <em>m</em>/<em>z</em> 441.573 and 372.1236 in MRM positive mode, correspondingly. The approach was shown accurate throughout a range of 3.0–60.0 ng ml<small>⁻¹</small> and correlation values of (<em>r</em><small>²</small>) ≥ 0.999.6 replicates including olutasidenib at 4 distinct QC levels were analyzed to determine intra-assay precision and accuracy; the Coefficient of variations (CV) were reported to be 3.41% to 0.58% to 0.31% to 0.36, and the accuracy ranged from 97.40, 99.69, 99.4, and 99.16%, respectively, for LOQQC, LQC, MQC, and HQC. In a pharmacokinetic investigation using rat plasma, this strategy has proven effective.</p>","PeriodicalId":102,"journal":{"name":"RSC Advances","volume":" 29","pages":" 23836-23844"},"PeriodicalIF":3.9,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/ra/d5ra01161b?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144581791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Do human individuals differ in their potential for lipophilic contaminant biomagnification?","authors":"Yuhao Chen, Terrence H Bell, Ying Duan Lei, Frank Wania","doi":"10.1039/d5em00285k","DOIUrl":"https://doi.org/10.1039/d5em00285k","url":null,"abstract":"<p><p>Biomagnification is the process that leads to the chemical potential of organic contaminants in an organism exceeding that in its diet. Despite its obvious importance, studies on biomagnification in humans are rare, in particular those that seek to quantify and characterize interindividual differences in biomagnification potential. Applying a method based on equilibrium sampling and chemical analysis of paired dietary and fecal samples we determined the thermodynamic limit to biomagnification (BMF_lim) as well as a feces-based biomagnification factor (BMF_F) for a selection of polychlorinated biphenyls in five human volunteers sharing the same diet over a period of five days. Four younger participants displayed similar BMF_lim and BMF_F, while an older participant's BMF_lim and BMF_F were higher by factors of up to 5 and 7, respectively. These differences were due to divergent dietary digestion efficiencies, with lipid assimilation efficiency ranging from 93 to 99%. Small sample size prevented us from confirming whether lipid assimilation efficiency is influenced by the participants' gut microbiomes. Fugacities in blood and feces, were highly correlated for each participant, but the relationships were different between participants. Only the younger participants had contaminant fugacities in blood that greatly exceeded those in feces, consistent with a fat flush effect, whereas contaminants were close to chemical equilibrium between blood and feces in the older participant. Differences in biomagnification are likely to contribute to the variability in contaminant levels within a population that is typically observed in biomonitoring.</p>","PeriodicalId":74,"journal":{"name":"Environmental Science: Processes & Impacts","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144582609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Individual and combined toxicities of fluorescent polystyrene nanoplastics and chromium(III) nitrate nonahydrate in <i>Artemia salina</i>.","authors":"Mahalakshmi Kamalakannan, John Thomas, Natarajan Chandrasekaran","doi":"10.1039/d5em00251f","DOIUrl":"https://doi.org/10.1039/d5em00251f","url":null,"abstract":"<p><p>There is a growing apprehension on the toxic effects of various pollutants on marine ecosystems. This study was aimed to investigate the influence of the combination of 200 nm fluorescent polystyrene nanoplastics (F-PSNPs) and chromium(III) nitrate nonahydrate (CNN) on their toxicity in <i>Artemia salina</i>, a marine crustacean. The interaction between CNN and F-PSNPs in natural seawater resulted in the formation of micron-sized particles. This interaction also caused a decrease in F-PSNP fluorophore intensity. Reduced residual CNN concentration within the mixture indicated CNN binding to F-PSNPs. Acute toxicity tests were conducted on <i>Artemia salina</i> using different concentrations of F-PSNPs alone, CNN alone, and the F-PSNPs + CNN complex. The study assessed the potential toxicity of these emerging contaminants by examining the mortality rates, hatching success, morphological changes, and biochemical alterations in <i>Artemia salina</i>. Exposure to the F-PSNPs + CNN complex resulted in a decreased hatching success, an increased mortality rate, elevated levels of reactive oxygen species, catalase, lipid peroxidase, and superoxide dismutase, and reduced total protein content, and the independent action model suggested an additive toxic effect of the complex. Significant differences were noted between the impact of the complex and the individual. However, the accumulation of these particles in organisms may affect the food chain. These findings underscore the potential environmental risks associated with the concurrent exposure of aquatic organisms to nanoplastics and other co-contaminating heavy metals.</p>","PeriodicalId":74,"journal":{"name":"Environmental Science: Processes & Impacts","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144582610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>Weizmannia coagulans</i> BC99 alleviates hyperuricemia by restoring liver-kidney-gut axis dysfunction caused by hyperuricemia.","authors":"Ying Wu, Yinyin Gao, Cheng Li, Shirui Zhai, Yao Dong, Shanshan Tie, Lina Zhao, Shaobin Gu","doi":"10.1039/d5fo00951k","DOIUrl":"https://doi.org/10.1039/d5fo00951k","url":null,"abstract":"<p><p>Hyperuricemia (HUA) has emerged as a global metabolic disorder that poses significant risks to human health. To investigate the effects and mechanisms of <i>Weizmannia coagulans</i> BC99 in alleviating hyperuricemia, we established a hyperuricemia mouse model. The results demonstrate that BC99 significantly downregulates the expression of uric acid (UA) reabsorption proteins in the kidneys and intestines, while upregulating the expression of UA excretion proteins. This modulation leads to a reduction in UA synthesis, mediated through the Nrf2/NLRP3 pathway. Additionally, BC99 intervention restored gut microbiota intestinal dysbiosis in HUA mice, increased the beneficial short-chain fatty acid (SCFA)-producing bacterial genera, and corrected disturbances in amino acid, purine, and pyrimidine metabolism. Collectively, our findings suggest that BC99 exhibits strong anti-hyperuricemic effects and holds promise as a dietary supplement for lowering uric acid levels.</p>","PeriodicalId":77,"journal":{"name":"Food & Function","volume":" ","pages":""},"PeriodicalIF":5.1,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144582612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oxidation upcycling of polyethylene into degradable, recyclable and high-performance materials.","authors":"Chengfeng Shen, Xiangyue Wei, Qiang Zhang, Pengbo Ye, Xuehui Liu, Shimei Xu, Yu-Zhong Wang","doi":"10.1039/d5mh00967g","DOIUrl":"https://doi.org/10.1039/d5mh00967g","url":null,"abstract":"<p><p>Polyethylene waste was oxidatively converted into hydroxyl-terminated telechelic macromolecules with controlled molecular weights, which were further reconstructed into sustainable materials with enhanced strength, processability, degradability/recyclability, and filler compatibility through dynamic cross-linking. This strategy enables efficient upcycling of PE into sustainable, high-performance polymers, addressing plastic pollution and advancing circular materials.</p>","PeriodicalId":87,"journal":{"name":"Materials Horizons","volume":" ","pages":""},"PeriodicalIF":12.2,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144582630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Self-assembly and thermal conductivity of amphiphilic Janus nanoparticles under nanoslit confinement","authors":"Azmil Haris Azhar, Yusei Kobayashi, Takahiro Ikeda and Masashi Yamakawa","doi":"10.1039/D5RA03226A","DOIUrl":"https://doi.org/10.1039/D5RA03226A","url":null,"abstract":"<p >The interplay between nanoparticle (NP) interaction anisotropy and nanoscale confinement gives rise to diverse self-assembly behaviors and the resulting macroscopic thermal properties. In this study, we use molecular dynamics (MD) simulations to explore the relationship between the structural and thermal properties of nanofluids confined in nanoscale channels. The chemical surface design of NPs alters the dependence of thermal conductivity on channel width: homogeneous hydrophilic (HI) NPs maintain thermal conductivity by forming a stable adsorption layer around dispersed NPs, whereas diblock Janus NPs exhibit clustering effects due to interaction anisotropy. This clustering weakens adsorption layers, reducing thermal conductivity even under weak confinement. Under strong confinement, solvent molecules form more pronounced structured layers near the walls; however, NPs disrupt this ordering, resulting in lower thermal conductivity than in a confined purely solvent system. Diblock Janus NPs, in particular, disrupt these layers more due to their clustering, further hindering thermal conductivity. Although both NP types exhibit reduced Brownian motion as channel width decreases, we conclude that it does not significantly affect the thermal conductivity of nanofluids. For instance, Janus NPs, which exhibit greater Brownian motion in wider channels, still show lower thermal conductivity than HI NPs. While HI NPs form stable adsorption layers that enhance thermal transport, Janus NPs tend to self-assemble into micelles, weakening the adsorption layer and further reducing thermal conductivity. Our study provides molecular insight into the relationship between NP dynamics, surface properties, and adsorption layers in determining the thermal conductivity of confined nanofluids.</p>","PeriodicalId":102,"journal":{"name":"RSC Advances","volume":" 29","pages":" 23588-23595"},"PeriodicalIF":3.9,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/ra/d5ra03226a?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144573068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antibacterial, antioxidant, and scolicidal activity investigation of biosynthesized ZnO NPs using Zhumeria majdae essential oil and hydroalcoholic extract","authors":"Rana Kiani, Zahra Rafiee, Damoun Razmjoue, Ahmad Oryan, Mehrorang Ghaedi and Hassan Abidi","doi":"10.1039/D5RA01192B","DOIUrl":"https://doi.org/10.1039/D5RA01192B","url":null,"abstract":"<p >The biosynthesis of zinc oxide nanoparticles (ZnO NPs) from the <em>Zhumeria majdae</em> plant is reported in this study. Additionally, the essential oil and hydroalcoholic extract of this plant were manufactured and their antibacterial, antioxidant, and scolicidal activities were investigated. The essential oil was analyzed using GC/MS spectroscopy. The UV-vis spectrum of ZnO NPs exhibited an absorption maximum at 368 nm. The XRD and EDS confirmed the hexagonal structure of ZnO NPs and the presence of zinc. FE-SEM indicated well-defined cubic NPs. The FT-IR spectrum of ZnO NPs revealed the presence of functional groups, including flavonoids and polyphenolic biomolecules. The antibacterial activity of biosynthesized ZnO NPs, essential oil, and hydroalcoholic extract against <em>Staphylococcus aureus</em> and <em>Pseudomonas aeruginosa</em> was evaluated. Additionally, the scolicidal activity of various concentrations of these treatment regimens was investigated on protoscoleces of hydatid cysts at different time intervals. Furthermore, the antioxidant activity of these products was assessed using DPPH and FRAP tests. The antimicrobial effects of ZnO NPs, hydroalcoholic extract, and essential oil on <em>Staphylococcus aureus</em> and <em>Pseudomonas aeruginosa</em> were confirmed. The treatments demonstrated significant effects on protoscolexes of hydatid cysts at various time intervals, and their lethal effects were validated. From the findings of this study, it is believed that the essential oil of the <em>Zhumeria majdae</em> plant is more effective on some species of bacteria and also has significant scolicidal properties.</p>","PeriodicalId":102,"journal":{"name":"RSC Advances","volume":" 29","pages":" 23461-23476"},"PeriodicalIF":3.9,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/ra/d5ra01192b?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144573097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"S-decorated Mo2C as efficient catalyst for Li–O2 battery system","authors":"Yanhong Ding, Zhichao Gao, Rongpeng Lin, Yong Cao, Haoyang Liu, Yulin Zhou, Haifeng Xu, Jiayi Liu, Fangqi Ren and Yirong Zhu","doi":"10.1039/D5RA02021B","DOIUrl":"https://doi.org/10.1039/D5RA02021B","url":null,"abstract":"<p >Lithium–oxygen (Li–O<small>₂</small>) batteries are considered an important candidate for the next generation of energy storage systems due to their ultra-high theoretical energy density (11 586 mA h g<small>⁻¹</small>), but their slow kinetic reactions, high overpotential and cyclic instability seriously limit their practical applications. In this study, sulfur modified Mo<small>₂</small>C (S@Mo<small>₂</small>C) cathode materials were prepared by hydrothermal synthesis by sulfur (S) doping to optimize the electronic structure and catalytic activity of Mo<small>₂</small>C (Mo<small>₂</small>C). Experiments show that S@Mo<small>₂</small>C exhibits significantly improved electrochemical performance compared to commercial Mo<small>₂</small>C: its specific capacity is up to 3955 mA h g<small>⁻¹</small> (commercial material only 508 mA h g<small>⁻¹</small>), the charge and discharge overpotential is reduced to 0.26 V (53.6%), and the capacity retention rate remains 77.8% after 250 cycles. X-ray diffraction (XRD), transmission electron microscopy (TEM) and X-ray photoelectron spectroscopy (XPS) analysis showed that the introduction of sulfur induced the formation of a heterostructure of MoS<small>₂</small>/MoS<small>₃</small> in the Mo<small>₂</small>C lattice, which enhanced the conductivity and oxygen reduction/precipitation (ORR/OER) activity of the material. In addition, sulfur doping promotes the formation of highly conductive amorphous Li<small>₂</small>O<small>₂</small> and effectively inhibits the accumulation of insulating ring Li<small>₂</small>O<small>₂</small>, thus significantly improving the cycle stability and energy efficiency of the battery. This study provides a new structural regulation strategy for the design of high efficiency lithium oxygen battery catalysts.</p>","PeriodicalId":102,"journal":{"name":"RSC Advances","volume":" 29","pages":" 23819-23826"},"PeriodicalIF":3.9,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/ra/d5ra02021b?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144581782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}