The Royal Society of Chemistry最新文献

{"title":"Uncovering the biosynthetic pathways of key flavor and color compounds in pomegranate using pathway-based metabolomics†","authors":"Jin-Pyo An, Dongjoo Kim, Xuebo Song, John M. Chater, Claire C. Heinitz and Yu Wang","doi":"10.1039/D5RA00511F","DOIUrl":"https://doi.org/10.1039/D5RA00511F","url":null,"abstract":"<p >Pomegranate, a subtropical fruit renowned for its sensory appeal and nutritional benefits, has garnered global attention due to its distinctive flavor profile and putative health benefits. Enhancing fruit quality, particularly in terms of flavor, could significantly boost consumer preference and market demand. However, the development of flavor is a complex process that requires a deep understanding of the metabolic pathways that contribute to it. In this study, a comprehensive metabolomics approach employing gas chromatography mass spectrometry (GC/MS) and liquid chromatography mass spectrometry (LC/MS) techniques was used to identify flavor compounds and their precursors. To account for distinctive pomegranate compounds, anthocyanins and punicalagins were analyzed as well. Four key flavor-related pathways (shikimate/phenylpropanoid pathway, terpenoid backbone biosynthesis, lipoxygenase pathway, and tricarboxylic acid cycle metabolism) were explored to identify the regulatory mechanisms behind flavor compound production. Notably, Wonderful, a dominant cultivar in California, up-regulated most pathways to produce flavor-related secondary metabolites from their precursors. These findings offer a valuable foundation for breeding efforts aimed at improving sensory traits in pomegranate, ultimately enhancing consumer satisfaction.</p>","PeriodicalId":102,"journal":{"name":"RSC Advances","volume":" 28","pages":" 22831-22842"},"PeriodicalIF":3.9,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/ra/d5ra00511f?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144550785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"1,2-Diaminocyclohexane-derived chiral tetradentate ligands for Mn(i)-catalyzed asymmetric hydrogenation of ketones†","authors":"Yi Su, Dongzhi Zhu, Zhifeng Ma, Yizhou Wang, Zechen Wang, Zheng Wang, Yanping Ma and Wen-Hua Sun","doi":"10.1039/D5RA03062E","DOIUrl":"https://doi.org/10.1039/D5RA03062E","url":null,"abstract":"<p >A series of (<em>R</em>,<em>R</em>)-1,2-diaminocyclohexane-based chiral PNNP and SNNS tetradentate ligands were successfully employed as chiral chelating ligands for the asymmetric hydrogenation (AH) of substituted acetophenones (13 examples) with good activity and good enantioselectivity (up to 85% ee). In particular, two types of manganese(<small>I</small>) complexes (<strong>Mn1</strong> and <strong>Mn2</strong>) with a “C<img>N” or “NH” group were isolated, and their comparative performance as catalysts revealed <strong>Mn1</strong> as more effective in AH of ketones with a maximum enantiomeric excess (ee) value of 85%. DFT calculations revealed that the formation of the major S-type 1-phenylethanol by <strong>Mn1</strong> was significantly influenced by steric repulsion between the substrate and ligand.</p>","PeriodicalId":102,"journal":{"name":"RSC Advances","volume":" 28","pages":" 23097-23102"},"PeriodicalIF":3.9,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/ra/d5ra03062e?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144558044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Two-dimensional materials for adaptive functionalities in soft robotics.","authors":"Yun Li, Jiamin Amanda Ong, Pooi See Lee","doi":"10.1039/d5mh00565e","DOIUrl":"https://doi.org/10.1039/d5mh00565e","url":null,"abstract":"<p><p>Two-dimensional (2D) materials are critical for applications in tactile perception, health monitoring, virtual reality (VR), augmented reality (AR) and human-machine interfaces. In particular, recent advances in materials science, device fabrication, and machine learning have significantly propelled the applications of 2D materials for multifunctional soft robots owing to their flexible and conformal nature. In this review, we provide an overview of the fundamental mechanisms and recent breakthroughs in 2D materials for soft robotic systems, with a focus on their fabrication techniques, actuation mechanisms, and multiple sensing approaches. Subsequently, we highlight the significance of 2D materials in multimodal devices and feedback loop control for intelligent and smart robotics with self-adaptive manipulation. We then explore innovations such as multimodal sensing, human-robot interaction and artificial intelligence (AI)-promoted fast recognition. Finally, we summarize the future research directions and challenges, such as the reliable preparation roadmap for 2D materials and streamlined configuration to eradicate heavy wiring and enhance the dexterity of soft robots.</p>","PeriodicalId":87,"journal":{"name":"Materials Horizons","volume":" ","pages":""},"PeriodicalIF":12.2,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144558525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Conformation driven conductance modulation in single-stranded RNA (ssRNA).","authors":"Arpan De, Arindam K Das, M P Anantram","doi":"10.1039/d5nh00241a","DOIUrl":"https://doi.org/10.1039/d5nh00241a","url":null,"abstract":"<p><p>The structural attributes of RNA, especially co-transcriptional folding, have enabled RNA origami to construct complex 3D architectures, serving as a platform to build RNA-based nanodevices. However, the potential of RNA in molecular electronics is largely unexplored, mainly due to its inherent conformational fluctuations. Although this variability poses challenges for a precise understanding of the conductance properties of RNA, it also offers opportunities for tuning RNA-based molecular devices by exploiting their dynamic nature. Accordingly, our objectives in this paper are twofold: (i) how do conformational fluctuations impact the charge transport properties of single stranded RNA (ssRNA), and (ii) how can these fluctuations be controlled? Toward that end, we first established a benchmark for ssRNA instability compared to double stranded RNA (dsRNA) based on molecular dynamics. Subsequently, we explore quantum transport across 123 distinct conformations, which show that the average conductance of ssRNA is 1.7 × 10^-3 G₀, but with a high standard deviation of around 5.2 × 10^-3<i>G</i>₀. We demonstrate that the conductance of ssRNA is influenced primarily by backbone bending and nucleotide positioning. Specifically, while backbone bending tends to result in higher conductance at reduced end-to-end phosphorus distances, nucleotide positioning introduces significant stochasticity. To mitigate this variability, we also demonstrate that increasing the salt concentration can stabilize ssRNA, presenting a viable strategy for minimizing conductance fluctuations. Our findings reveal that if ssRNA conductance can be switched between folded and unfolded states, it can offer two distinct conductance modes. We anticipate the programmability of ssRNA folding and durability, coupled with its conductivity, can be leveraged for advancing molecular electronics.</p>","PeriodicalId":93,"journal":{"name":"Nanoscale Horizons","volume":" ","pages":""},"PeriodicalIF":8.0,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144558529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Toward high sustainability using fully recycled geopolymer concrete: mechanical, rheological, and microstructural properties†","authors":"Faramarz Moodi, Mohammad Reza Hanafi and Zahra Shariatinia","doi":"10.1039/D5RA02249E","DOIUrl":"https://doi.org/10.1039/D5RA02249E","url":null,"abstract":"<p >This study explores the sustainable production of fully recycled geopolymer concrete using waste ordinary Portland cement (OPC) concrete, aiming to reduce environmental impact and promote circular construction practices. Crushed OPC concrete was utilized as both recycled aggregate (RA) and recycled concrete powder (RCP), while recycled clay brick powder (RBP) was incorporated as a supplementary aluminosilicate additive. Alkaline activation was performed using sodium hydroxide solutions at three molarities (8, 12, and 16 M) combined with water glass (WG) at a WG/NaOH ratio of 2. The mechanical, rheological, and microstructural properties of geopolymer recycled concrete (GRC) and paste (GRP) were assessed alongside a Life Cycle Assessment (LCA). Results showed that incorporating RA and RCP significantly enhanced compressive strength—up to 90% at 90 days compared to geopolymer paste—while increasing NaOH molarity improved overall mechanical performance. Although RBP decreased compressive strength, density, and elastic modulus, it notably enhanced workability, surface quality, and crack resistance. Microstructural analysis revealed strong adhesion between RCP and RA due to their chemical compatibility, contributing to matrix homogeneity. The LCA confirmed that GRC exhibits a lower environmental footprint than conventional OPC concrete. These findings support the classification of GRC as a high-performance structural material and demonstrate its potential as a viable, eco-friendly alternative for sustainable construction applications.</p>","PeriodicalId":102,"journal":{"name":"RSC Advances","volume":" 28","pages":" 22953-22971"},"PeriodicalIF":3.9,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/ra/d5ra02249e?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144558050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heat transfer fluids: amino acid anion ionic liquid based IoNanofluids with remarkable thermal conductivity and low viscosity†","authors":"Anshu Chandra, Yamini Sudha Sistla, Mir Atiq Ahmed, Durga Vijay Shankar Vasireddy, Nancy Jaglan, Nipu Kumar Das, Tamal Banerjee and Venkata Subbarayudu Sistla","doi":"10.1039/D5RA03752B","DOIUrl":"https://doi.org/10.1039/D5RA03752B","url":null,"abstract":"<p >Present study aims to develop ionic liquid based nanofluids (IoNanofluids) exhibiting low viscosity, high thermal conductivity, thermal stability, high specific heat capacity and colloidal stability for potential heat transfer fluids applications. Four amino acid anion ionic liquids (AAIL) such as 1-butyl,3-metylimidazolium glycinate, 1-butyl,3-metylimidazolium arginate, 1-ethyl,3-metylimidazolium glycinate, 1-ethyl,3-metylimidazolium arginate were synthesized. The IoNanofluids (INF) were developed by adding 0.05 wt% of MWCNT to the AAILs. The effect of MWCNT concentration and surfactant was investigated by developing INFs consisting of 1-butyl, 3-methylimidazolium tetrafluoroborate ([bmim]<small>⁺</small>[BF<small>₄</small>]<small>⁻</small>) and MWCNT in the range of 0.025–0.1 wt%. The AAILs showed significantly less viscosity (18–8 mPa s at 298 K), higher thermal conductivity and specific heat capacity compared to several conventional ionic liquids. The four AAIL INFs showed 21–40% enhancement in thermal conductivity; very less viscosity (20 mPa s <em>vs.</em> 110 mPa s at 300 K), and remarkably higher specific heat capacity (10 J g<small>⁻¹</small> °C <em>vs.</em> 1 J g<small>⁻¹</small> °C) compared to [bmim]<small>⁺</small>[BF<small>₄</small>]<small>⁻</small> INF. The AAIL INFs showed fine and homogeneous dispersion of MWCNT and substantially higher colloidal stability (30 days) compared to [bmim]<small>⁺</small>[BF<small>₄</small>]<small>⁻</small> (7 days) and [bmim]<small>⁺</small>[BF<small>₄</small>]<small>⁻</small> + MWCNT + CTAB (14 days). The AAIL INFs of present study showed enhanced heat transfer properties than several literature reported INFs made from conventional ionic liquids. Therefore, based on the overall properties, the AAIL INFs developed in present study could be suitable for applications such as heat exchangers, thermal energy storage systems, cooling of microprocessor systems broadly in the temperature range of 0–200 °C.</p>","PeriodicalId":102,"journal":{"name":"RSC Advances","volume":" 29","pages":" 23146-23164"},"PeriodicalIF":3.9,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/ra/d5ra03752b?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144558053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FeCu₃-LDH/MoS₂ superlattice-modified carbon paper as an integrated sensor for the sensitive detection of nitrofurantoin in various samples.","authors":"Xueting Wang, Yuehua Li, Boran Tong, Xingwen Wang, Wei Meng, Jing Zhang, Chao Han","doi":"10.1039/d5ay00463b","DOIUrl":"https://doi.org/10.1039/d5ay00463b","url":null,"abstract":"<p><p>Nitrofurantoin (NFT) is a broad-spectrum antibiotic used for the treatment of humans, poultry and livestock. Improper use and discharge of NFT can cause serious harm to human health and the environment. Electrochemical analysis has been widely employed in antibiotic detection because of its advantages of simple operation, high sensitivity and rapid response. However, few studies have reported the detection of NFT using this method owing to the limited availability of electrode materials. Layered double hydroxides (LDHs) have attracted widespread attention because of their unique structure and chemical properties as well as the advantages of homogeneous dispersion of laminate elements and adjustable chemical composition. However, their application in NFT detection has rarely been reported due to the inherent defects of weak conductivity and poor stability. To better use LDHs and overcome their shortcomings, a series of superlattice FeCu₃-LDH/MoS₂ materials were successfully designed using stripping and self-assembly strategies. FeCu₃-LDH/MoS₂ modified carbon paper (CP) was used as an integrated sensor for NFT detection. Benefiting from the structural advantages of the superlattice material and dual-synergistic catalysis between the LDH and MoS₂, FeCu₃-LDH/MoS₂/CP (1 : 1) exhibited highly sensitive NFT detection, with a low detection limit. FeCu₃-LDH/MoS₂/CP (1 : 1) could also be successfully applied for NFT determination in real samples, such as human serum, lake water and commercialized drugs, with satisfactory recovery. This work not only provides an effective electrochemical detection method for NFT determination, but also broadens the application of LDHs in the electrochemical field and lays a foundation for the controllable preparation of electrochemical sensors based on superlattice materials.</p>","PeriodicalId":64,"journal":{"name":"Analytical Methods","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144558532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outstanding Reviewers for <i>ChemComm</i> in 2024.","authors":"","doi":"10.1039/d5cc90204e","DOIUrl":"https://doi.org/10.1039/d5cc90204e","url":null,"abstract":"<p><p>We would like to take this opportunity to thank all of <i>ChemComm</i>'s reviewers for helping to preserve quality and integrity in chemical science literature. We would also like to highlight the Outstanding Reviewers for <i>ChemComm</i> in 2024.</p>","PeriodicalId":67,"journal":{"name":"Chemical Communications","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144558537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Co-administration of curcumin forms with supplemental iron: a study of effects on iron absorption and intestinal cellular health.","authors":"Marta M Gámez-Fernández, Helena Tiekou Lorinczova, Stefanie Ho Yi Chan, Satyanarayana Somavarapu, Vinood B Patel, Sanjoy K Deb, Mohammed Gulrez Zariwala","doi":"10.1039/d5fo00658a","DOIUrl":"https://doi.org/10.1039/d5fo00658a","url":null,"abstract":"<p><p>Iron deficiency (ID) and iron deficiency anaemia (IDA) are significant global public health issues, with their main line of treatment being oral iron supplementation that often leads to gastrointestinal (GI) adverse effects and early discontinuation. Strategies to improve the efficiency of oral iron supplements and to ameliorate their associated GI effects could help resolve ID and IDA. Curcumin, a potent antioxidant and anti-inflammatory, iron chelating compound from turmeric may mitigate some of these issues. This study aimed to mechanistically assess the interaction of iron (20 and 100 μM) with two different forms of curcumin - native, unformulated curcumin <i>versus</i> a formulated curcumin (HydroCurc®) at 5, 10 and 20 μM, and the consequent effects on iron uptake and intestinal cellular health. Presence of formulated curcumin incremented ferritin levels by 160.5% <i>versus</i> free iron treatment alone (<i>p</i> < 0.0001) in intestinal Caco-2 cells. A greater ferric iron reducing power by the formulated curcumin was observed (<i>p</i> < 0.001). Formulated curcumin also protected against iron-induced permeability of the intestinal barrier (<i>p</i> < 0.05). Our data points to formulated curcumin's ability to limit oxidation of divalent iron as a possible mechanism to explain the greater iron uptake by intestinal cells. This study characterises for the first time the distinct interaction behaviour of curcumin forms with iron and the potential consequences on iron uptake and intestinal health, providing novel insights that may help optimise therapeutic approaches to tackle ID and IDA.</p>","PeriodicalId":77,"journal":{"name":"Food & Function","volume":" ","pages":""},"PeriodicalIF":5.1,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144558542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing microscale printing accuracy in LCD-based 3D printing using an immobilized release film.","authors":"Chang Tian, Chaojie Shao, Tiantian Li, Wenya Tang, Peiqi Wu, Qian Xu, Wei Li, Fen Zhang","doi":"10.1039/d5lc00452g","DOIUrl":"https://doi.org/10.1039/d5lc00452g","url":null,"abstract":"<p><p>With the development of 3D printing technology, liquid crystal display (LCD)-based 3D printing offers a cost-effective solution for microfluidic device fabrication, yet its microscale precision remains limited. The accuracy of printing molds can be improved by reducing the adhesion force between the cured resin and release film. However, the adhesion force between the LCD screen and release film and the deformation of the release film in the separation process are still ignored. Herein, we propose using an immobilized release film to enhance the printing accuracy in microscale printing for microfabrication. By applying transparent double-sided adhesive tape between the LCD screen and release film, the movement and deformation of the release film can be reduced, the vertical accuracy in the process of microscale 3D printing can be improved, and the error rate in height can be reduced from 20% to 5%. By studying the printing effect under different layer heights, it was found that when the layer height was set as 20-30 μm, the printed micromold matched the design features in both size and side structure. Moreover, microstructures less than 30 μm in width can be obtained. Besides, the reproducibility of the immobilized release film across different resins was confirmed. Furthermore, microfluidic chips used in concentration gradient generation can be obtained with a minimum cross section of 204 μm. Finally, we used the printed mold to fabricate a PDMS chip in the study of silicosis and the preventive effect of NAC in silicosis. Moreover, the mechanism of the preventive effect of NAC was studied. We believe that our fabrication technique with an immobilized release film will facilitate the development of microfluidic technology, and expand the scope and application of microfluidics in research and applications in diverse fields, such as analytical biochemistry, pharmaceuticals, and medicine.</p>","PeriodicalId":85,"journal":{"name":"Lab on a Chip","volume":" ","pages":""},"PeriodicalIF":6.1,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144558543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}