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Metal-free, photoredox-catalyzed aromatization-driven deconstructive functionalization of spiro-dihydroquinazolinones with α-CF3 alkenes. 无金属、光氧化催化芳香化驱动的螺二氢喹唑啉酮与α-CF3 烯的解构官能化。
IF 4.3 2区 化学
Chemical Communications Pub Date : 2024-07-12 DOI: 10.1039/d4cc02868f
Jin-Hua Zhang, Hong-Jie Miao, Jia-Yi Li, Wenke Li, Pengchen Ma, Xin-Hua Duan, Li-Na Guo
{"title":"Metal-free, photoredox-catalyzed aromatization-driven deconstructive functionalization of spiro-dihydroquinazolinones with α-CF<sub>3</sub> alkenes.","authors":"Jin-Hua Zhang, Hong-Jie Miao, Jia-Yi Li, Wenke Li, Pengchen Ma, Xin-Hua Duan, Li-Na Guo","doi":"10.1039/d4cc02868f","DOIUrl":"https://doi.org/10.1039/d4cc02868f","url":null,"abstract":"<p><p>Metal-free, photoredox-catalyzed aromatization-driven deconstructive functionalization of spiro-dihydroquinazolinones with α-CF<sub>3</sub> alkenes is presented. The readily available spiro-dihydroquinazolinones reacted efficiently with α-CF<sub>3</sub> alkenes during photocatalysis to give the <i>gem</i>-difluoroallylated and the CF<sub>3</sub>-containing quinazolin-4(3<i>H</i>)-ones in good yields with excellent chemoselectivity. The selectivity depends on the electron effect of substituents in α-CF<sub>3</sub> alkenes. A wide range of four-, five-, six-, seven-, eight- and twelve-membered spiro-dihydroquinazolinones were compatible with this transformation. The protocol is also characterized by the mild and redox-neutral reaction conditions, good functional group compatibility and excellent atom economy. Mechanistic studies revealed that the reaction proceeds <i>via</i> a radical pathway.</p>","PeriodicalId":67,"journal":{"name":"Chemical Communications","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2024-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141588950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis of 1-aryl-2,3-diaroyl cyclopropanes from 1,3,5-triaryl-1,5-diketones and their transformation into E,E-1,4-diaryl-1,3-butadienes† 从 1,3,5-三芳基-1,5-二酮合成 1-芳基-2,3-二芳基环丙烷并将其转化为 E,E-1,4-二芳基-1,3-丁二烯†。
IF 3.9 3区 化学
RSC Advances Pub Date : 2024-07-12 DOI: 10.1039/D4RA02525C
Kashpar John Britto, Maniarasu Meenakshi and Kannupal Srinivasan
{"title":"Synthesis of 1-aryl-2,3-diaroyl cyclopropanes from 1,3,5-triaryl-1,5-diketones and their transformation into E,E-1,4-diaryl-1,3-butadienes†","authors":"Kashpar John Britto, Maniarasu Meenakshi and Kannupal Srinivasan","doi":"10.1039/D4RA02525C","DOIUrl":"https://doi.org/10.1039/D4RA02525C","url":null,"abstract":"<p >A new method for the synthesis of 1-aryl-2,3-diaroyl cyclopropanes has been developed by iodine/DBU-mediated cyclization of 1,3,5-triaryl-1,5-diketones. The alcohols derived by the reduction of these cyclopropanes, when treated with conc. HCl, afforded a series of 1,3-dienes through cyclopropyl ring-opening and subsequent fragmentation. Overall, the synthetic sequence represents a new non-Wittig methodology for the synthesis of 1,3-dienes from 1,5-diketones.</p>","PeriodicalId":102,"journal":{"name":"RSC Advances","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2024/ra/d4ra02525c?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141602606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Metal-free oxidative coupling of aryl acetylene with elemental sulphur and amines: facile access to α-ketothioamides. 芳基乙炔与元素硫和胺的无金属氧化偶联:轻松获得 α-硫代酮酰胺。
IF 2.9 3区 化学
Organic & Biomolecular Chemistry Pub Date : 2024-07-12 DOI: 10.1039/d4ob00830h
Deepika Sharma, Rana Chatterjee, Vasudevan Dhayalan, Rambabu Dandela
{"title":"Metal-free oxidative coupling of aryl acetylene with elemental sulphur and amines: facile access to α-ketothioamides.","authors":"Deepika Sharma, Rana Chatterjee, Vasudevan Dhayalan, Rambabu Dandela","doi":"10.1039/d4ob00830h","DOIUrl":"https://doi.org/10.1039/d4ob00830h","url":null,"abstract":"<p><p>A simple and efficient oxidative coupling of aromatic alkynes with elemental sulphur and secondary amines has been reported. The iodine/DMSO system easily promoted the transformations, affording thioglyoxamides <i>via</i> C-S, C-O, and C-N bond formations. In this context, acetylenic C-H bond oxidation has occurred through iodination, leading to the desired products. Moreover, this metal-free, one-pot protocol is accomplished by using readily available starting materials, without external oxidants, and under aerobic conditions, providing a variety of α-ketothioamide compounds in moderate to good yields.</p>","PeriodicalId":96,"journal":{"name":"Organic & Biomolecular Chemistry","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141588989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis, enzyme inhibition assay, and molecular modeling study of novel pyrazolines linked to 4-methylsulfonylphenyl scaffold: antitumor activity and cell cycle analysis† 与 4-甲基磺酰基苯基支架相连的新型吡唑类化合物的合成、酶抑制实验和分子模型研究:抗肿瘤活性和细胞周期分析†。
IF 3.9 3区 化学
RSC Advances Pub Date : 2024-07-12 DOI: 10.1039/D4RA03902E
Alaa A.-M. Abdel-Aziz, Adel S. El-Azab, Simone Brogi, Rezk R. Ayyad, Hamad M. Alkahtani, Hatem A. Abuelizz, Ibrahim A. Al-Suwaidan and Abdulrahman M. Al-Obaid
{"title":"Synthesis, enzyme inhibition assay, and molecular modeling study of novel pyrazolines linked to 4-methylsulfonylphenyl scaffold: antitumor activity and cell cycle analysis†","authors":"Alaa A.-M. Abdel-Aziz, Adel S. El-Azab, Simone Brogi, Rezk R. Ayyad, Hamad M. Alkahtani, Hatem A. Abuelizz, Ibrahim A. Al-Suwaidan and Abdulrahman M. Al-Obaid","doi":"10.1039/D4RA03902E","DOIUrl":"https://doi.org/10.1039/D4RA03902E","url":null,"abstract":"<p >Antitumor activity using 59 cancer cell lines and enzyme inhibitory activity of a newly synthesized pyrazoline-linked 4-methylsulfonylphenyl scaffold (compounds <strong>18a–q</strong>) were measured and compared with those of standard drugs. Pyrazolines <strong>18b</strong>, <strong>18c</strong>, <strong>18f</strong>, <strong>18g</strong>, <strong>18h</strong>, and <strong>18n</strong> possessed significant antitumor activity, with a positive cytotoxic effect (PCE) of 22/59, 21/59, 21/59, 48/59, 51/59, and 20/59, respectively. The cancer cell lines HL60, MCF-7, and MDA-MB-231 were used to measure the IC<small><sub>50</sub></small> values of derivatives <strong>18c</strong>, <strong>18g</strong>, and <strong>18h</strong> <em>via</em> the MTT assay method, and the results were compared with those of reference drugs. Derivatives <strong>18g</strong> and <strong>18h</strong> showed potent and broad-spectrum antitumor activities against HL60 (IC<small><sub>50</sub></small> of 10.43, 8.99 μM, respectively), MCF-7 (IC<small><sub>50</sub></small> of 11.7 and 12.4 μM, respectively), and MDA-MB-231 (IC<small><sub>50</sub></small> of 4.07 and 7.18 μM, respectively). Compound <strong>18c</strong> exhibited strong antitumor activity against HL60 and MDA-MB-231 cell lines with IC<small><sub>50</sub></small> values of 8.43 and 12.54 μM, respectively, and moderate antitumor activity against MCF-7 cell lines with an IC<small><sub>50</sub></small> value of 16.20 μM. Compounds <strong>18c</strong>, <strong>18g</strong>, and <strong>18h</strong> remarkably inhibited VEGFR2 kinase (IC<small><sub>50</sub></small> = 0.218, 0.168, and 0.135 μM, respectively) compared with the reference drug sorafenib (IC<small><sub>50</sub></small> = 0.041 μM). Compounds <strong>18g</strong> and <strong>18h</strong> effectively inhibited HER2 kinase (IC<small><sub>50</sub></small> = 0.496 and 0.253 μM, respectively) compared with erlotinib (IC<small><sub>50</sub></small> = 0.085 μM). Compound <strong>18h</strong> inhibited EGFR kinase (IC<small><sub>50</sub></small> = 0.574 μM) with a potency comparable with that of the reference drug erlotinib (IC<small><sub>50</sub></small> = 0.105 μM). Pyrazolines <strong>18c</strong>, <strong>18f</strong>, and <strong>18h</strong> arrested the S/G2 phase of the cell cycle in HL-60 cells. In addition, derivatives <strong>18c</strong>, <strong>18f</strong>, and <strong>18h</strong> revealed lower Bcl-2 protein expression anti-apoptotic levels and higher Bax, caspase-3, and caspase-9 expression levels. Molecular docking studies of derivative <strong>18h</strong> into the binding sites of EGFR, HER2, and VEGFR2 kinases explored the interaction mode of these pyrazoline derivatives and their structural requirements for antitumor activity.</p>","PeriodicalId":102,"journal":{"name":"RSC Advances","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2024/ra/d4ra03902e?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141602619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sonophotocatalytic degradation of sulfamethoxazole using lanthanum ferrite perovskite oxide anchored on an ultrasonically exfoliated porous graphitic carbon nitride nanosheet 利用锚定在超声剥离多孔氮化石墨碳纳米片上的镧系铁氧体过氧化物对磺胺甲噁唑进行声光催化降解
IF 3.9 3区 化学
RSC Advances Pub Date : 2024-07-12 DOI: 10.1039/D4RA03096F
Ajibola A. Bayode, Andrea Osti and Antonella Glisenti
{"title":"Sonophotocatalytic degradation of sulfamethoxazole using lanthanum ferrite perovskite oxide anchored on an ultrasonically exfoliated porous graphitic carbon nitride nanosheet","authors":"Ajibola A. Bayode, Andrea Osti and Antonella Glisenti","doi":"10.1039/D4RA03096F","DOIUrl":"https://doi.org/10.1039/D4RA03096F","url":null,"abstract":"<p >The lanthanum ferrite perovskite (La<small><sub>0.8</sub></small>FO) was synthesized using a citric combustion route and then modified with a porous graphitic nitride nanosheet <em>via</em> the wet impregnation-assisted ultrasonic method to produce La<small><sub>0</sub></small>.<small><sub>8</sub></small>FO@PgNS. Various techniques such as Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), scanning electron microscopy (SEM), energy dispersive X-ray (EDX) spectroscopy, X-ray photoelectron spectroscopy (XPS), ultraviolet diffuse reflectance spectroscopy (UV-DRS), and Tauc plot analysis were employed to confirm the functional moieties, crystallinity, phase change, morphology, composition, and bandgap of La.<small><sub>0.8</sub></small>FO and La<small><sub>0</sub></small>.<small><sub>8</sub></small>FO@PgNS. La<small><sub>0.8</sub></small>FO and La<small><sub>0</sub></small>.<small><sub>8</sub></small>FO@PgNS were used for the sonophotocatalytic oxidative degradation of sulfamethoxazole (SMX) under low energy and ultrasound wave frequency in the presence of visible light. La<small><sub>0.8</sub></small>FO and La<small><sub>0</sub></small>.<small><sub>8</sub></small>FO@PgNS exhibited a sonophotocatalytic degradation capacity of 52.06 and 99.60%, respectively. Furthermore, the rate constant at the optimum condition of pH 7 and 5 mg L<small><sup>−1</sup></small> concentration was 0.01343 and 0.01494 min<small><sup>−1</sup></small> for La<small><sub>0.8</sub></small>FO and La<small><sub>0</sub></small>.<small><sub>8</sub></small>FO@PgNS, respectively. The integration of sonolysis and photocatalysis in the remediation process of SMX resulted in a synergy of 2.5-fold. Ultrasonic waves and hydroxyl and superoxide radicals are the main species governing the degradation process while La<small><sub>0</sub></small>.<small><sub>8</sub></small>FO@PgNS was stable over 8 cycles, proving to be a sustainable material for environmental remediation.</p>","PeriodicalId":102,"journal":{"name":"RSC Advances","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2024/ra/d4ra03096f?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141602605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Insights into structure, morphology and conductivity of the earth-abundant NASICON phosphate, Na4MnFe(PO4)3† 对富含地球的 NASICON 磷酸盐 Na4MnFe(PO4)3† 的结构、形态和导电性的深入研究
IF 3.9 3区 化学
RSC Advances Pub Date : 2024-07-12 DOI: 10.1039/D4RA03529A
Loubna Chayal, Sirine El Arni, Mohamed Saadi, Abderrazzak Assani, Lahcen Bih, Jiwei Ma and Mohammed Hadouchi
{"title":"Insights into structure, morphology and conductivity of the earth-abundant NASICON phosphate, Na4MnFe(PO4)3†","authors":"Loubna Chayal, Sirine El Arni, Mohamed Saadi, Abderrazzak Assani, Lahcen Bih, Jiwei Ma and Mohammed Hadouchi","doi":"10.1039/D4RA03529A","DOIUrl":"https://doi.org/10.1039/D4RA03529A","url":null,"abstract":"<p >Phosphate-based NASICON materials are an excellent candidate for both electrode and solid electrolyte materials in sodium-ion batteries (SIBs). The development of new NASICON materials with higher ionic and electronic conductivities based on low cost and abundant elements is necessary for advancement of SIBs. In this study, we report the structure, morphology and conductivity of the earth-abundant Mn/Fe-based NASICON phosphate Na<small><sub>4</sub></small>MnFe(PO<small><sub>4</sub></small>)<small><sub>3</sub></small>. Pure phase powders were synthesized by solution-assisted solid-state reaction, sol–gel and Pechini methods. From refined X-ray diffraction data, the prepared phosphate was found to crystallize in trigonal symmetry with space group <em>R</em><img><em>c</em>. The effect of synthesis method on microstructure and conductivity was investigated using scanning electron microscopy (SEM), atomic force microscopy (AFM) and impedance measurements. Smaller particle size and regular distribution of the powder was designed using a Pechini route. Impedance measurement showed a notable enhancement in conductivity, from 0.543 × 10<small><sup>−7</sup></small> to 1.52 × 10<small><sup>−7</sup></small> S cm<small><sup>−1</sup></small> at 30 °C, when the powder synthesis method was altered from a solution-assisted solid-state reaction to the Pechini route, highlighting the remarkable effect of the synthesis method on conductivity.</p>","PeriodicalId":102,"journal":{"name":"RSC Advances","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2024/ra/d4ra03529a?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141602621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Removal and detection of phenols through an SPE-HPLC method using microporous organic networks as adsorbent. 使用微孔有机网络作为吸附剂,通过 SPE-HPLC 方法去除和检测苯酚。
IF 2.7 3区 化学
Analytical Methods Pub Date : 2024-07-12 DOI: 10.1039/d4ay00799a
Azam Ali, Huipeng Sun, Syed Faheem Askari Rizvi, Ding Nana, Haixia Zhang
{"title":"Removal and detection of phenols through an SPE-HPLC method using microporous organic networks as adsorbent.","authors":"Azam Ali, Huipeng Sun, Syed Faheem Askari Rizvi, Ding Nana, Haixia Zhang","doi":"10.1039/d4ay00799a","DOIUrl":"https://doi.org/10.1039/d4ay00799a","url":null,"abstract":"<p><p>The design and development of a facile synthesis approach to construct novel materials for the rapid adsorption and removal of environmental pollutants are of significant interest. In this work, we report the rational design and facile synthesis of magnetic core-shell-based microporous organic networks, Fe<sub>3</sub>O<sub>4</sub>@MON-TBPT-TEB (TTMON, achieved by reacting 2,4,6-tris(<i>p</i>-bromophenyl) triazine and 1,3,5-triethynylbenzene) and Fe<sub>3</sub>O<sub>4</sub>@MON-TBPM-DEBP (TDMON, achieved by reacting tetrakis (4-bromophenyl) methane and 4-4'-diethynylbiphenyl). These MONs possessed excellent dispersity, electrostatic attraction as well as plenty of π-π and hydrophobic interaction sites enabled them to efficiently absorb targeted environmental pollutants. TTMON and TDMON exhibited excellent adsorption capacities of 440 and 510 mg g<sup>-1</sup>, respectively, at 25 °C for 2,4,6-trichlorophenol (TCP). TCP, 2,4-dichlorophenol (DCP), 2-naphthol (2-NT) and 4-nitrophenol (4-NP) from aqueous solution were treated by both MONs, followed by their analysis with high-performance liquid chromatography (HPLC). For TDMON, the proposed SPE-HPLC-UV method showed an LOD of 0.03 μg L<sup>-1</sup>, LOQ of 0.11 μg L<sup>-1</sup>, and a wide linear range of 1-1000 μg L<sup>-1</sup> for TCP. The adsorption kinetics, thermodynamics, isotherms, effect of pH and humic acid (HA), ionic strength, regeneration, and reusability of the MONs were also studied. The results revealed that the novel-designed MONs have potential applications as efficient adsorbents in sample pretreatment.</p>","PeriodicalId":64,"journal":{"name":"Analytical Methods","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141588948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis and characterisation of copper(I) complexes with relevance to intramolecular Ullmann O,S-arylation. 与分子内乌尔曼 O,S-芳香化相关的铜(I)配合物的合成与表征。
IF 3.5 3区 化学
Dalton Transactions Pub Date : 2024-07-12 DOI: 10.1039/d4dt01418a
Xiaodong Jin, Bao-Nguyen T Nguyen, Robert P Davies
{"title":"Synthesis and characterisation of copper(I) complexes with relevance to intramolecular Ullmann <i>O</i>,<i>S</i>-arylation.","authors":"Xiaodong Jin, Bao-Nguyen T Nguyen, Robert P Davies","doi":"10.1039/d4dt01418a","DOIUrl":"https://doi.org/10.1039/d4dt01418a","url":null,"abstract":"<p><p>Copper-catalysed intramolecular Ullman arylation has been frequently used to synthesise benzoxazoles and benzothiazoles. Despite widespread use, investigations into the mechanism and speciation of copper-containing complexes relevant to the catalytic pathway have remained relatively limited. Accordingly, this study aims to elucidate the structural details of potential copper(I) intermediates through the analysis of their solid-state structures using X-ray crystallography, while also investigating the reactivities of these complexes. Five novel copper complexes are reported which are formed prior to the aryl halide activation step and feature distinct aggregation modes based on either Cu<sub>4</sub>N<sub>4</sub>O<sub>4</sub>C<sub>4</sub> or Cu<sub>4</sub>N<sub>4</sub>S<sub>4</sub>C<sub>4</sub> clusters.</p>","PeriodicalId":71,"journal":{"name":"Dalton Transactions","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2024-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141588951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction: Synthesis, docking and biological evaluation of purine-5-N-isosteres as anti-inflammatory agents 更正:作为抗炎剂的嘌呤-5-N-异甾烷的合成、对接和生物学评价
IF 3.9 3区 化学
RSC Advances Pub Date : 2024-07-12 DOI: 10.1039/D4RA90072C
Ahmed M. El-Saghier, Souhaila S. Enaili, Aly Abdou, Amany M. Hamed and Asmaa M. Kadry
{"title":"Correction: Synthesis, docking and biological evaluation of purine-5-N-isosteres as anti-inflammatory agents","authors":"Ahmed M. El-Saghier, Souhaila S. Enaili, Aly Abdou, Amany M. Hamed and Asmaa M. Kadry","doi":"10.1039/D4RA90072C","DOIUrl":"https://doi.org/10.1039/D4RA90072C","url":null,"abstract":"<p >Correction for ‘Synthesis, docking and biological evaluation of purine-5-<em>N</em>-isosteres as anti-inflammatory agents’ by Ahmed M. El-Saghier <em>et al.</em>, <em>RSC Adv.</em>, 2024, <strong>14</strong>, 17785–17800, https://doi.org/10.1039/D4RA02970D.</p>","PeriodicalId":102,"journal":{"name":"RSC Advances","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2024/ra/d4ra90072c?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141602608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A bifunctional Pasteurella multocida β1-3-galactosyl/N-acetylgalactosaminyltransferase (PmNatB) for the highly efficient chemoenzymatic synthesis of disaccharides. 用于高效化学合成双糖的多杀性巴氏杆菌β1-3-半乳糖基/N-乙酰半乳糖氨基转移酶(PmNatB)。
IF 2.9 3区 化学
Organic & Biomolecular Chemistry Pub Date : 2024-07-12 DOI: 10.1039/d4ob00889h
Xiaohong Yang, Bijoyananda Mishra, Hai Yu, Yijun Wei, Xi Chen
{"title":"A bifunctional <i>Pasteurella multocida</i> β1-3-galactosyl/<i>N</i>-acetylgalactosaminyltransferase (PmNatB) for the highly efficient chemoenzymatic synthesis of disaccharides.","authors":"Xiaohong Yang, Bijoyananda Mishra, Hai Yu, Yijun Wei, Xi Chen","doi":"10.1039/d4ob00889h","DOIUrl":"https://doi.org/10.1039/d4ob00889h","url":null,"abstract":"<p><p>Glycosyltransferases are nature's key biocatalysts for the formation of glycosidic bonds. Discovery and characterization of new synthetically useful glycosyltransferases are critical for the development of efficient enzymatic and chemoenzymatic strategies for producing complex carbohydrates and glycoconjugates. Herein we report the identification of <i>Pasteurella multocida</i> PmNatB as a bifunctional single-catalytic-domain glycosyltransferase with both β1-3-galactosyltransferase and β1-3-<i>N</i>-acetylgalactosaminyltransferase activities. It is a novel glycosyltransferase for constructing structurally diverse GalNAcβ3Galα/βOR and Galβ3GalNAcα/βOR disaccharides in one-pot multienzyme systems with <i>in situ</i> generation of UDP-sugars.</p>","PeriodicalId":96,"journal":{"name":"Organic & Biomolecular Chemistry","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141588957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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