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Uncovering the biosynthetic pathways of key flavor and color compounds in pomegranate using pathway-based metabolomics† 利用代谢组学方法揭示石榴中关键风味和颜色化合物的生物合成途径
IF 3.9 3区 化学
RSC Advances Pub Date : 2025-07-04 DOI: 10.1039/D5RA00511F
Jin-Pyo An, Dongjoo Kim, Xuebo Song, John M. Chater, Claire C. Heinitz and Yu Wang
{"title":"Uncovering the biosynthetic pathways of key flavor and color compounds in pomegranate using pathway-based metabolomics†","authors":"Jin-Pyo An, Dongjoo Kim, Xuebo Song, John M. Chater, Claire C. Heinitz and Yu Wang","doi":"10.1039/D5RA00511F","DOIUrl":"https://doi.org/10.1039/D5RA00511F","url":null,"abstract":"<p >Pomegranate, a subtropical fruit renowned for its sensory appeal and nutritional benefits, has garnered global attention due to its distinctive flavor profile and putative health benefits. Enhancing fruit quality, particularly in terms of flavor, could significantly boost consumer preference and market demand. However, the development of flavor is a complex process that requires a deep understanding of the metabolic pathways that contribute to it. In this study, a comprehensive metabolomics approach employing gas chromatography mass spectrometry (GC/MS) and liquid chromatography mass spectrometry (LC/MS) techniques was used to identify flavor compounds and their precursors. To account for distinctive pomegranate compounds, anthocyanins and punicalagins were analyzed as well. Four key flavor-related pathways (shikimate/phenylpropanoid pathway, terpenoid backbone biosynthesis, lipoxygenase pathway, and tricarboxylic acid cycle metabolism) were explored to identify the regulatory mechanisms behind flavor compound production. Notably, Wonderful, a dominant cultivar in California, up-regulated most pathways to produce flavor-related secondary metabolites from their precursors. These findings offer a valuable foundation for breeding efforts aimed at improving sensory traits in pomegranate, ultimately enhancing consumer satisfaction.</p>","PeriodicalId":102,"journal":{"name":"RSC Advances","volume":" 28","pages":" 22831-22842"},"PeriodicalIF":3.9,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/ra/d5ra00511f?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144550785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Intense pulsed light annealing of CdS and Au-decorated CdS nanoparticles for high-performance, self-powered silicon-based heterojunction photodetectors 用于高性能自供电硅基异质结光电探测器的CdS和au修饰CdS纳米颗粒的强脉冲光退火
IF 3.9 3区 化学
RSC Advances Pub Date : 2025-07-04 DOI: 10.1039/D5RA04075B
Hadeel F. Abbas, Raid A. Ismail, Walid K. Hamoudi and Mayyadah H. Mohsin
{"title":"Intense pulsed light annealing of CdS and Au-decorated CdS nanoparticles for high-performance, self-powered silicon-based heterojunction photodetectors","authors":"Hadeel F. Abbas, Raid A. Ismail, Walid K. Hamoudi and Mayyadah H. Mohsin","doi":"10.1039/D5RA04075B","DOIUrl":"https://doi.org/10.1039/D5RA04075B","url":null,"abstract":"<p >The enhancement of visible light responsivity in nanostructured heterojunction silicon photodetectors has attracted significant research interest. In this work, intense pulsed light (IPL) annealing was employed to improve the performance of CdS/Si and Au-decorated CdS/Si photodetectors fabricated <em>via</em> laser ablation. X-ray diffraction (XRD) confirms a substantial improvement in crystallinity of both CdS and Au-decorated CdS after IPL annealing. The particle size of the CdS increased from 78 to 100 nm and from 10 to 15 nm for Au-decorated CdS after annealing. The mobility of the CdS and Au-decorated CdS increases after annealing. The optical energy gap of CdS increases from 2.55 to 2.68 eV after annealing. Photoluminescence studies of CdS nanoparticles after annealing show the presence of an intense single peak at 450 nm. Structural and optical analyses reveal that IPL annealing reduced defects and enlarged the depletion layer width, giving a twofold responsivity increase from 0.19 to 0.36 A W<small><sup>−1</sup></small> at 520 nm for CdS/Si and 0.23 to 0.42 A W<small><sup>−1</sup></small> at 460 nm for Au-decorated CdS/Si. The obtained results indicated that IPL annealing was rapid and optimized heterojunction photodetectors. The energy band diagram of Au-decorated CdS/Si after annealing was constructed under illumination. The effect of aging time on the performance of the fabricated photodetectors was investigated.</p>","PeriodicalId":102,"journal":{"name":"RSC Advances","volume":" 28","pages":" 22989-23002"},"PeriodicalIF":3.9,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/ra/d5ra04075b?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144550819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In vivo and in vitro investigations provide insights into maleidride biosynthesis in fungi† 体内和体外研究提供了真菌中马来酰胺生物合成的见解
IF 3.9 3区 化学
RSC Advances Pub Date : 2025-07-04 DOI: 10.1039/D5RA02147B
Katherine Williams, Catherine E. Spencer, Kate M. J. de Mattos-Shipley, Anjali D. Shah, Trong-Tuan Dao, Jonathan A. Davies, David M. Heard, Zhongshu Song, Ashley J. Winter, Matthew P. Crump, Christine L. Willis and Andrew M. Bailey
{"title":"In vivo and in vitro investigations provide insights into maleidride biosynthesis in fungi†","authors":"Katherine Williams, Catherine E. Spencer, Kate M. J. de Mattos-Shipley, Anjali D. Shah, Trong-Tuan Dao, Jonathan A. Davies, David M. Heard, Zhongshu Song, Ashley J. Winter, Matthew P. Crump, Christine L. Willis and Andrew M. Bailey","doi":"10.1039/D5RA02147B","DOIUrl":"https://doi.org/10.1039/D5RA02147B","url":null,"abstract":"<p >Maleidrides are a family of polyketide-derived natural products isolated from filamentous fungi, that can exhibit significant bioactivities. These compounds are classified according to the size of their central carbocyclic ring, to which one or more maleic anhydride moieties are attached. The studies described herein provide important insights into maleidride biosynthesis, in particular the pathways to the nonadrides scytalidin and castaneiolide, and the octadride zopfiellin. We propose a supportive role for isochorismatase-like enzymes, which are commonly encoded within maleidride biosynthetic gene clusters, in facilitating α-ketoglutarate dependent dioxygenase-mediated catalysis. This is evidenced by gene deletions as well as enzyme assays, for two maleidride biosynthetic pathways: that of zopfiellin, from <em>Diffractella curvata</em>; and of scytalidin, from <em>Scytalidium album</em>. These experiments collectively underscore the significance of the isochorismatase-like enzymes in the catalytic process of α-ketoglutarate dependent dioxygenases. Feeding studies with either scytalidin or an unsaturated analogue to <em>D. curvata</em> Δ<em>zopPKS</em> both gave the 5,6-diol, castaneiolide and the structure was confirmed by NMR and X-ray crystallography. Furthermore, a putative biosynthetic gene cluster for castaneiolide biosynthesis was identified from a <em>de novo</em> genome assembly of the native producer, <em>Macrophoma castaneicola</em>.</p>","PeriodicalId":102,"journal":{"name":"RSC Advances","volume":" 28","pages":" 22799-22806"},"PeriodicalIF":3.9,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/ra/d5ra02147b?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144550813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reductive degradation of carbon tetrachloride using tree leaf polyphenol–iron complexes for groundwater remediation† 利用树叶多酚-铁络合物还原降解地下水中的四氯化碳[j]
IF 3.9 3区 化学
RSC Advances Pub Date : 2025-07-04 DOI: 10.1039/D5RA01391G
Roselle Colastre Lasagas, Chenju Liang, Xuyen Thi Hong Luong and Florencio Ballesteros
{"title":"Reductive degradation of carbon tetrachloride using tree leaf polyphenol–iron complexes for groundwater remediation†","authors":"Roselle Colastre Lasagas, Chenju Liang, Xuyen Thi Hong Luong and Florencio Ballesteros","doi":"10.1039/D5RA01391G","DOIUrl":"https://doi.org/10.1039/D5RA01391G","url":null,"abstract":"<p >Plant polyphenols, natural antioxidants, form complexes with iron minerals that enhance contaminant degradation <em>via</em> reductive processes. This study investigated the degradation of carbon tetrachloride (CT) using polyphenol–iron complexes synthesized from tree leaf extracts. Polyphenols were extracted from waste tree leaves, including <em>Ficus microcarpa</em>, <em>Terminalia neotaliala</em>, <em>Haematoxylon campechianum</em>, <em>Ficus septica</em>, <em>Mangifera indica</em>, and <em>Ficus religiosa</em>, with gallic acid identified as the predominant constituent. Among them, <em>Terminalia neotaliala</em> exhibited superior antioxidant capacity, reducing power, metal-chelating ability, and total phenolic content, making it the optimal choice for CT degradation experiments. Using the Taguchi method, optimal conditions for CT degradation were determined as pH 10, a leaf extract dose of 10 g L<small><sup>−1</sup></small>, and an Fe<small><sup>2+</sup></small> concentration of 15 mM, with pH as the most influential factor. Under these conditions, CT degradation reached 99% in aqueous solution and 89% in field groundwater within 24 h. Detected intermediates included trichloromethane, dichloromethane, and chloromethane, with chloride ions as the final mineralization product. This study underscores the potential of tree leaf polyphenols, in combination with Fe<small><sup>2+</sup></small>, as a sustainable approach for groundwater remediation.</p>","PeriodicalId":102,"journal":{"name":"RSC Advances","volume":" 28","pages":" 22915-22929"},"PeriodicalIF":3.9,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/ra/d5ra01391g?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144550816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Organic fibrous nanostructures via the droplet-assisted growth and shaping (DAGS) mechanism 有机纤维纳米结构通过液滴辅助生长和成形(DAGS)机制
IF 3.9 3区 化学
RSC Advances Pub Date : 2025-07-04 DOI: 10.1039/D5RA01919B
Rabab Azizi and Stefan Seeger
{"title":"Organic fibrous nanostructures via the droplet-assisted growth and shaping (DAGS) mechanism","authors":"Rabab Azizi and Stefan Seeger","doi":"10.1039/D5RA01919B","DOIUrl":"https://doi.org/10.1039/D5RA01919B","url":null,"abstract":"<p >The Droplet-Assisted Growth and Shaping mechanism (DAGS) represents a bottom-up approach for the fabrication of versatile one-dimensional polymeric (1D) nanomaterials and involves the polymerisation of a highly reactive monomer with water nanodroplets formed on a substrate surface. The unidimensional growth of the resulting polymer is sustained with its water insolubility. To date, all 1D polymeric nanostructures grown <em>via</em> the DAGS mechanism were either based on silicone, alumina, or germanium oxide but not on a carbonic backbone. In this paper, we demonstrate for the first time that the DAGS mechanism can also be used for the growth of organic 1D polymeric nanostructures using ethyl-2-cyanoacrylate (ECA) as a monomer. The polymerisation is carried out in <em>n</em>-hexane/toluene mixtures with different water contents (WCs). The obtained poly(ethyl-2-cyanoacrylate) (PECA) fibrous nanostructures (PECA-FNS), which were coated on glass, manifested as nanofibers and nanoribbons with an aspect ratio ranging from 4.9 to 18.3. Attenuated total reflectance infrared (ATR-IR) spectroscopy revealed the presence of the carbonyl bond on the coated glass substrates, confirming the presence of the PECA-FNS. The topography and the root mean square roughness (Sq) of the PECA-FNS were examined <em>via</em> atomic force microscopy (AFM). Both static contact angle measurements and UV-Vis spectrophotometry showed that the PECA-FNS coatings displayed a high transparency and moderate hydrophobicity.</p>","PeriodicalId":102,"journal":{"name":"RSC Advances","volume":" 28","pages":" 23045-23053"},"PeriodicalIF":3.9,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/ra/d5ra01919b?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144550821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Copper(ii) chelates of a coumarin-based acyl hydrazone ligand: structural characterization and computational evaluations for prospective applications in antimicrobial, antiviral, antioxidant, and anticancer therapies† 以香豆素为基础的酰基腙配体的铜螯合物:结构表征和计算评估在抗菌、抗病毒、抗氧化和抗癌治疗中的应用前景
IF 3.9 3区 化学
RSC Advances Pub Date : 2025-07-04 DOI: 10.1039/D5RA03317A
Manar. S. Mahfouz, Amira A. M. Ali, Magdy Shebl, Omima M. I. Adly and R. Fouad
{"title":"Copper(ii) chelates of a coumarin-based acyl hydrazone ligand: structural characterization and computational evaluations for prospective applications in antimicrobial, antiviral, antioxidant, and anticancer therapies†","authors":"Manar. S. Mahfouz, Amira A. M. Ali, Magdy Shebl, Omima M. I. Adly and R. Fouad","doi":"10.1039/D5RA03317A","DOIUrl":"https://doi.org/10.1039/D5RA03317A","url":null,"abstract":"<p >This study represents the synthesis and comprehensive characterization of four novel copper(<small>II</small>) chelates (<strong>CuR</strong>, <strong>CuRCT</strong>, <strong>CuH</strong>, and <strong>CuHCT</strong>) derived from a newly developed coumarin-based acyl hydrazone ligand (<strong>HCBH</strong>). The chelates were prepared using multidisciplinary synthetic routes, including reflux and hydrothermal methods with or without surfactant assistance, resulting in distinct mono- and binuclear structures with nanoscale morphologies. Structural analyses confirmed that all copper complexes possess tetrahedral geometries, with ligand coordination modes varying between tridentate and tetradentate depending on the synthetic method. TEM imaging revealed unique morphologies for each chelate, and the successful dispersion of the bioactive <strong>CuH</strong> chelate into silica yielded a porous nanostructured drug delivery system. Biological evaluations revealed promising antimicrobial activity, particularly for <strong>CuHCT</strong> against <em>E. coli</em> and <em>S. aureus</em>, and for <strong>CuRCT</strong> against <em>B. subtilis</em> and <em>C. albicans</em>. Antioxidant assays showed that <strong>CuRCT</strong> and <strong>CuHCT</strong> exhibited superior activity compared to other complexes and standard ascorbic acid. <strong>CuH</strong> demonstrated potent cytotoxicity against HepG-2 and MCF-7 cancer cell lines, comparable to cisplatin, while maintaining moderate toxicity toward normal Vero cells (CC<small><sub>50</sub></small> = 43.34 ± 1.98 μg ml<small><sup>−1</sup></small>). Although the antiviral activity of <strong>CuH</strong> against HAV was weak, <em>in vitro</em> release studies of <strong>CuH</strong>–silica composites confirmed controlled release behavior, supporting its potential as a nanodrug delivery system. Density Functional Theory (DFT) and molecular docking analyses corroborated the biological findings, with favorable interactions observed between the compounds and CDK2 kinase. Collectively, these results highlight <strong>CuH</strong> as a highly promising candidate for further preclinical evaluation, especially in cancer therapy, with silica-based dispersion enhancing its potential as a nanocarrier for targeted drug delivery.</p>","PeriodicalId":102,"journal":{"name":"RSC Advances","volume":" 28","pages":" 22972-22988"},"PeriodicalIF":3.9,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/ra/d5ra03317a?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144550818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mn and Cu complexes of a novel malic acid–cysteine ligand with remarkable ROS scavenging activity† 一种具有显著活性氧清除活性的新型苹果酸-半胱氨酸配体的Mn和Cu配合物
IF 3.9 3区 化学
RSC Advances Pub Date : 2025-07-04 DOI: 10.1039/D5RA02118A
Saeedeh Khadivi-Derakhshan, Mahtab Pirouzmand, Jafar Soleymani and Mehdi D. Esrafili
{"title":"Mn and Cu complexes of a novel malic acid–cysteine ligand with remarkable ROS scavenging activity†","authors":"Saeedeh Khadivi-Derakhshan, Mahtab Pirouzmand, Jafar Soleymani and Mehdi D. Esrafili","doi":"10.1039/D5RA02118A","DOIUrl":"https://doi.org/10.1039/D5RA02118A","url":null,"abstract":"<p >The scientific community is very interested in investigating antioxidant activity using various assays to treat oxidative stress and reduce the harmful effects of free radicals. Cysteine, a sulfur-containing compound can treat oxidative stress. The primary objective of this study was to create a novel ligand through the combination of <small>L</small>-cysteine with malic acid and its metal complexes with copper and manganese. The following discussion focuses on how the complexes mimic natural antioxidant enzymes and explains how they could be used to remove reactive oxygen species. Various methods were used to verify the synthesis, including FT-IR, UV-vis, TGA, CHNS, EDX, SEM, mass, and fluorescence. These techniques indicated structural changes upon complexation and integration with β-CD. Spectrophotometric tests were used to evaluate the compounds' peroxidase-, catalase-, and superoxide dismutase-like activities under different conditions. Cytotoxicity was evaluated using HFF-2 cells and the MTT test. The amounts of carbon, hydrogen, nitrogen, and sulfur were 39.48, 4.7, 6.58, and 15.23, and the ligand formula is C<small><sub>7</sub></small>H<small><sub>11</sub></small>NSO<small><sub>6</sub></small>. Changes in infrared spectral signals upon metal interaction, particularly in the carboxylate region, indicate significant metal–ligand bonding. The results showed that the β-CD-modified complexes, especially Cu-complex/β-CD and Mn-complex/β-CD, had better antioxidant activity (91% and 78%, respectively). They were better at scavenging O<small><sub>2</sub></small>˙<small><sup>−</sup></small> radicals and breaking down H<small><sub>2</sub></small>O<small><sub>2</sub></small> into safe byproducts. Additionally, Mn-complex/β-CD was less cytotoxic. In conclusion, the produced complexes are promising antioxidants and potential treatments for diseases linked to oxidative stress, especially the β-CD derivatives.</p>","PeriodicalId":102,"journal":{"name":"RSC Advances","volume":" 27","pages":" 22006-22017"},"PeriodicalIF":3.9,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/ra/d5ra02118a?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144550786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Anticancer efficacy of bis-heteroleptic iridium(iii) complexes with difluoro-substituted phenylpyridine ligands† 含二氟取代苯基吡啶配体的双异痫性铱(iii)配合物的抗癌功效
IF 3.9 3区 化学
RSC Advances Pub Date : 2025-07-04 DOI: 10.1039/D5RA03076E
Suvasmita Behera, Kahnu Charan Pradhan, Sahadev Barik, Moloy Sarkar, Jagadish Kumar, Jagneshwar Dandapat, Jyotsnarani Pradhan and Satyanarayan Pal
{"title":"Anticancer efficacy of bis-heteroleptic iridium(iii) complexes with difluoro-substituted phenylpyridine ligands†","authors":"Suvasmita Behera, Kahnu Charan Pradhan, Sahadev Barik, Moloy Sarkar, Jagadish Kumar, Jagneshwar Dandapat, Jyotsnarani Pradhan and Satyanarayan Pal","doi":"10.1039/D5RA03076E","DOIUrl":"https://doi.org/10.1039/D5RA03076E","url":null,"abstract":"<p >A series of iridium(<small>III</small>) complexes (<strong>Ir1–Ir3</strong>) with the formula [Ir(F<small><sub>2</sub></small>ppy)<small><sub>2</sub></small>(L)] (F<small><sub>2</sub></small>ppy = 2-(2,4-difluoro-phenyl)pyridine, L = pyridine-2-aldoxime, 2-pyridylamidoxime and di-2-pyridylketoxime) were synthesized through the reaction of [(F<small><sub>2</sub></small>ppy)<small><sub>2</sub></small>Ir(μ-Cl)<small><sub>2</sub></small>Ir(F<small><sub>2</sub></small>ppy)<small><sub>2</sub></small>] (SM1) and the respective ancillary ligands (L). All the complexes were characterised by FT-IR, <small><sup>1</sup></small>H &amp; <small><sup>19</sup></small>F-NMR analysis, electronic absorption–emission spectroscopy and cyclic voltammetric studies. Molecular structures of complexes <strong>Ir1</strong> and <strong>Ir3</strong> were determined by interpreting single crystal X-ray data. All the complexes were found to be luminescent with low quantum yields. Anticancer studies on cancer cell lines MDAMB, HT-29 and LN-229 revealed their effectiveness as antiproliferative agents. The cytotoxicity of the complexes was evaluated using the MTT assay and complex <strong>Ir2</strong> showed activity similar to that of cisplatin towards the three cancer cells. The elevated level of reactive oxygen species (ROS) in the iridium complex-treated cancer cells further supported the antiproliferation efficacy of <strong>Ir1–Ir3</strong>. Further, the effectiveness of <strong>Ir1–Ir3</strong> on cancer cells was established through a cell migration study and apoptotic induction assay on LN-229 and a colony formation assay on HT-29 cancer cells. Immunocytochemistry analysis of LN-229 cancer cells revealed apoptosis through the p53-dependent pathway.</p>","PeriodicalId":102,"journal":{"name":"RSC Advances","volume":" 28","pages":" 22875-22888"},"PeriodicalIF":3.9,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/ra/d5ra03076e?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144550815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effective synthesis of benzodiazepine sulfonamide-based MGAT2 inhibitors and evaluation of their antitumor activity† 苯二氮卓类磺胺类MGAT2抑制剂的有效合成及其抗肿瘤活性评价
IF 3.9 3区 化学
RSC Advances Pub Date : 2025-07-04 DOI: 10.1039/D5RA01108F
Yuying Zhang, Yalei Li, Xiaoyue Liu, Yi Wang, Huachuan Zheng and Dejun Zhou
{"title":"Effective synthesis of benzodiazepine sulfonamide-based MGAT2 inhibitors and evaluation of their antitumor activity†","authors":"Yuying Zhang, Yalei Li, Xiaoyue Liu, Yi Wang, Huachuan Zheng and Dejun Zhou","doi":"10.1039/D5RA01108F","DOIUrl":"https://doi.org/10.1039/D5RA01108F","url":null,"abstract":"<p >This study synthesized benzodiazepine sulfonamide-based MGAT2 inhibitors to combat cancer recurrence and resistance. Despite modest effects, compounds <strong>13</strong> and <strong>16</strong> showed enhanced antitumor activity. The six-step synthesis method using amino acids is industrially viable, offering a basis for future drug development.</p>","PeriodicalId":102,"journal":{"name":"RSC Advances","volume":" 28","pages":" 23003-23006"},"PeriodicalIF":3.9,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/ra/d5ra01108f?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144550820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Study on the influence of different factors on the direct treatment of high turbidity water by microfiltration processes 不同因素对微滤工艺直接处理高浊度水的影响研究
IF 3.9 3区 化学
RSC Advances Pub Date : 2025-07-03 DOI: 10.1039/D5RA01817J
Xiaosan Song, Ping Li, Qingchao Shen, Wenxuan Wei and Hairong Yan
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