The Royal Society of Chemistry最新文献

{"title":"Co-assembly of amphiphilic triblock copolymers with DNA-polymer targeting ligands in solution.","authors":"Junwei Zhou, Menghan Zou, Xiandeng Qiu, Rong Wang","doi":"10.1039/d5sm00107b","DOIUrl":"https://doi.org/10.1039/d5sm00107b","url":null,"abstract":"<p><p>The development of targeted drug delivery systems is highly valued, which not only improves the therapeutic effect of drugs, but also reduces the amount of drugs used and reduces side effects. By taking advantage of the excellent affinity and specificity of nucleic acid aptamers and co-assembly of targeting ligands with polymers, we used dissipative particle dynamics (DPD) simulations to explore the co-assembly behavior of amphiphilic ABA triblock copolymers and DNA-polymer targeting ligands in dilute solutions. By adjusting interaction parameters and concentrations of various components, we observed the formation of different targeting polymer nanostructures, such as targeting polymeric vesicles, sphere-like micelles, and disk-like micelles. The results show that the inclusion of targeting ligands prolongs the formation time of polymeric vesicles, and by modulating the interactions between DNA beads with hydrophilic beads and solvent beads, the localization of targeting ligands within the vesicles can be precisely controlled. When the interactions between DNA beads with hydrophilic beads <i>a</i>_TS is high, the targeting ligands aggregate on the vesicle exterior, while at lower <i>a</i>_TS values, they are uniformly distributed inside the vesicles. Additionally, the polymer and targeting ligand concentrations will influence the morphology of the aggregates, transitioning from sphere-like micelles to disk-like micelles and eventually to vesicles, including the mixture of multiple aggregate types under certain conditions. The findings provide theoretical support for the development of multi-targeted polymeric vesicles, advancing the field of precision therapy.</p>","PeriodicalId":103,"journal":{"name":"Soft Matter","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144482625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biopolymer-based electrospun nanofiber membranes for smart food packaging applications: a review","authors":"Maria Mathew, Sagitha Paroly and Sujith Athiyanathil","doi":"10.1039/D5RA02348C","DOIUrl":"https://doi.org/10.1039/D5RA02348C","url":null,"abstract":"<p >Food safety is an important concern impacting public health and the well-being of society. Novel food packaging systems are adopted by the market owing to the increased consumer preference for healthy food products. To minimize food spoilage, it is essential to monitor the food quality throughout the food supply chain in real time. The development of food packaging systems such as active and intelligent packaging has been greatly accelerated to meet these requirements. It relies on the development of new materials and technologies to monitor the quality, shelf life, and usability of food products for its end-users. Polymeric nanofibers, which can be easily functionalized, are good candidates for these applications. This review describes the role of electrospun nanofibers in fabricating various active and intelligent food packaging systems. Electrospun nanofibers encapsulated with bioactive ingredients can serve as a promising and environmentally sustainable alternative to conventional plastic systems for widespread use. Moreover, nanofiber packaging materials have many functional advantages such as controlled release of active agents, gas permeability, and flexibility. This review will be a valuable source of information for a wide group of researchers working in the area of electrospinning and biopolymer-based active and intelligent food packaging systems.</p>","PeriodicalId":102,"journal":{"name":"RSC Advances","volume":" 27","pages":" 21742-21779"},"PeriodicalIF":3.9,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/ra/d5ra02348c?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144481973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Freeze-drying enhances ToF-SIMS imaging of biological tissues <i>via</i> structural and metabolic preservation.","authors":"Hongzhe Ma, Mingru Liu, Yuxuan Zhang, Mengjiao Sun, Yanhua Chen, Zhaoying Wang, Zeper Abliz","doi":"10.1039/d5ay00550g","DOIUrl":"https://doi.org/10.1039/d5ay00550g","url":null,"abstract":"<p><p>In the ToF-SIMS <i>in situ</i> analysis of mouse liver tissue, freeze-drying is superior to room-temperature drying and chemical fixation, minimizing lipid spillage while maintaining structural integrity. Freeze-drying preserves tissue structure with minimal lipid loss, whereas room-temperature drying leads to lipid spreading and chemical fixation results in background noise. Freeze-drying balances structural integrity, molecular preservation, and spectral clarity, making it the optimal ToF-SIMS prep method. Although the method was tested on lipid-rich liver tissue, it provides a framework for tissue specific preparation of ToF-SIMS.</p>","PeriodicalId":64,"journal":{"name":"Analytical Methods","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144482559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiac troponin detection in one drop of saliva or urine for 10-minute assessment of acute myocardial infarction.","authors":"Xuelian Wu, Zewei Lian, Zhiyu Tan, Yaqun Yu, Tong Ren, Hua Shen, Jie Zhang, Shengli Jiang, Yundai Chen, Meng Su, Nan Cheng","doi":"10.1039/d5mh00525f","DOIUrl":"https://doi.org/10.1039/d5mh00525f","url":null,"abstract":"<p><p>Acute myocardial infarction (AMI) can be fatal with sudden death, heart failure, and cardiac rupture. However, it is a challenge to achieve point-of-care testing (POCT) for cardiac troponin T (CTnT), an acute myocardial infarction biomarker, using conventional ELISA because it requires professional expertise and involves time-consuming steps. Herein, we propose a printed immunosensing photonic crystal biochip (PCB), which enables the sensitive, convenient, and non-invasive detection of CTnT. The fluorescence enhancement property of the PCB enables detection of CTnT within 10 minutes, with a limit of detection of 0.25 pg mL^-1, compared to the conventional ELISA (2.5 h, 30 pg mL^-1). Owing to the hydrodynamic enrichment of the PCB, 10 μL of sample can be measured, minimizing interference from impurities in body fluids and human sampling errors. We used 100 clinical samples, including serum, saliva, and urine, to verify the reliability of the PCB assay; compared with ELISA, the PCB assay exhibited consistencies of 0.998, 0.999, and 0.999, respectively. Notably, monitoring the saliva of a patient with an AMI history using the PCB assay enables rapid therapeutic intervention within 30 minutes. The PCB was first used for non-invasive body fluid testing to provide reliable results for clinical diagnosis, with the potential to provide AMI health promotion.</p>","PeriodicalId":87,"journal":{"name":"Materials Horizons","volume":" ","pages":""},"PeriodicalIF":12.2,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144482610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A theoretical investigation of thermally activated delayed fluorescent palladium(II) complexes for organic light emitting diodes.","authors":"Zhiye Zhu, Zishuo Zhang, Chaoliang Zhao, Wanzhen Liang","doi":"10.1039/d5cp00732a","DOIUrl":"https://doi.org/10.1039/d5cp00732a","url":null,"abstract":"<p><p>It is of great importance and worth making efforts to shed light on the structure-property relationship and microscopic mechanism of thermally activated delayed fluorescence (TADF) emitters with high quantum yield by high-precision theoretical investigation. Here, we perform a detailed computational investigation to briefly elaborate the structure-TADF performance relationship and luminescence mechanism of the high efficiency of recently designed TADF emitter palladium(II) complexes named Pd1 and Pd2. The Pd(II) complexes show a high decay rate of S₁ → S₀, effective reverse intersystem crossing (RISC), and good relative stability of the T₁ state, which could be responsible for their excellent TADF performance in experiments.</p>","PeriodicalId":99,"journal":{"name":"Physical Chemistry Chemical Physics","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144482622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Topological transformations of isotropic droplets with breakup and formation of topological defects in a confined nematic geometry.","authors":"P V Dolganov, N A Spiridenko, V K Dolganov","doi":"10.1039/d5sm00345h","DOIUrl":"https://doi.org/10.1039/d5sm00345h","url":null,"abstract":"<p><p>Confined geometry and surface configuration can induce nontrivial structures and topological transformations between them. Here, we study complex transformations in the two-phase isotropic-nematic region in the confined geometry of a planar optical cell. We investigate the transformation of isotropic droplets induced by the isotropic-nematic transition, and the change of droplet Euler characteristic, accompanied by a change of the number and the total charge of topological defects on the surface of the isotropic droplet. We found that simple and multiple handled toroids with zero and negative Euler characteristics can be formed from sessile isotropic droplets. The complex dynamics of the isotropic-nematic interface were investigated. Rayleigh-Plateau instability with breakup of the toroid and creation of satellite isotropic droplets were found. The observed transformations are discussed on the basis of topology.</p>","PeriodicalId":103,"journal":{"name":"Soft Matter","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144482630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Smart functional binders empowering lithium-sulfur cathodes with enhanced atmospheric stability and catalytic kinetics.","authors":"Shengrui Cui, Ning Wang, Yanyun Zhang, Minghui Zhang, Youjun Xing, Tiancheng Wang, Weiya Li, Wei Liu, Seung-Taek Myung, Yongcheng Jin","doi":"10.1039/d5mh00867k","DOIUrl":"https://doi.org/10.1039/d5mh00867k","url":null,"abstract":"<p><p>Although lithium-sulfur (Li-S) batteries have attracted considerable research attention, several critical barriers must be overcome to bridge the gap between laboratory-scale achievements and practical commercial applications. For example, the notorious polysulfide shuttle effect, severe electrode volume changes, and challenging solid-liquid-solid conversion reactions. In this study, we have developed a multifunctional binder by incorporating cobalt(II) phthalocyanine (CoPc) into conventional poly(vinylidene fluoride) (PVDF) at a relatively lower processing temperature, which induces the phase transformation of α-PVDF to β-PVDF, thereby constructing an enhanced localized electric field with three advantages: (1) superior adsorption capabilities and catalytic activity, (2) robust mechanical properties that accommodate substantial volume fluctuations during cycling, and (3) excellent hydrophobic properties allowing for long-term storage in air. As a result, the batteries composed of an optimized PC-10 binder (CoPc added at 10%) maintain a specific capacity of 706 mA h g^-1 after 500 cycles at 0.5C, 399 mA h g^-1 at 2C after 1000 cycles with a decay rate of only 0.049% per cycle, and 80.5% capacity retention even under high sulfur loading (5 mg cm^-2). Moreover, the batteries maintained excellent discharge capacity with 1024 and 845 mA h g^-1 discharge specific capacities at 0.5C and 1C, respectively, even when the cathode with the PC-10 binder has been exposed to air for 20 days. This strategy has successfully established a multifunctional binder through a simple and feasible approach, offering new insights into addressing the inherent challenges of Li-S batteries.</p>","PeriodicalId":87,"journal":{"name":"Materials Horizons","volume":" ","pages":""},"PeriodicalIF":12.2,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144493221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antimicrobial cobaltocenium copolymers: tuning amphiphilicity against NDM-1 bacteria.","authors":"Md Waliullah Hossain, Ian Brand, Swagatam Barman, Alimi Abidoun, JiHyeon Hwang, Adam Parris, Xiaoming Yang, Prakash Nagarkatti, Mitzi Nagarkatti, Chuanbing Tang","doi":"10.1039/d5bm00497g","DOIUrl":"10.1039/d5bm00497g","url":null,"abstract":"<p><p>The emergence of Gram-negative superbugs coupled with a steep decline in antibiotic pipelines has imposed a serious threat to global public health. Cationic metallopolymers have gained significant attention due to their antimicrobial efficacy. In this work, we developed a range of broad-spectrum antimicrobial cobaltocenium and ammonium containing copolymers with different compositions, which attain the amphiphilic balance without compromising the total charges for enhanced interaction with bacterial membranes. The copolymers showed high antimicrobial efficacy with greater selectivity than the corresponding ammonium-containing methacrylate polymers. The mechanistic investigations of the lead polymer using bacterial strains harboring the New Delhi metallo-β-lactamase (NDM-1) enzyme revealed its membrane-active nature. The copolymer with 69% dimethyl cobaltocenium showed a minimal increase in the minimal inhibitory concentration over 14 passages, whereas polymyxin-B showed a 256-fold increase. These findings provided insights into metallopolymers with optimal amphiphilicity as potent antimicrobial agents to tackle Gram-negative superbugs.</p>","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12189181/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144482595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A lysosome targetable and acidic pH-activated fluorescent probe for two-photon imaging of hydrogen sulfide in live cells and animals.","authors":"YuJia Fu, XiaoFeng Guo, Hong Wang","doi":"10.1039/d5ay00757g","DOIUrl":"https://doi.org/10.1039/d5ay00757g","url":null,"abstract":"<p><p>The design strategy of targeted fluorescent probes usually involves modifying the probes with organelle-targeting groups, which then guide the probes to enter specific organelles by the traction of the targeting groups. However, the targeting ability of subcellular localization groups is not perfect, and the target analytes are not specifically distributed within the cells. Therefore, designing novel molecular fluorescent probes for highly specific and selective detection of target analytes within specific organelles is an important research direction that deserves attention. Although multiple high-efficiency lysosomal localization fluorescent probes for H₂S have been developed, the pH range for the fluorescence response of these probes to H₂S does not match the specific acidic range of the lysosome very well. In this work, by analyzing the relationship between the structures of the pH-responsive groups and the response range, excellent acidic pH-activated lysosome-localized fluorescent probes Lyso-NP-DS and Lyso-NP-NBD with a better performance have been developed. After the reaction with H₂S, the fluorescence activation pH ranges of their derivatives were between 2.5 and 5.5, 3.0 and 5.5, respectively. However, this could not only solve the problem of insufficient matching between the pH activation range for the fluorescence response to H₂S and the specific acidic range within the lysosome, but it also shows the characteristics of two-photon excitation and high sensitivity. This effectively avoids the background interference and extracellular fluorescence interference in the lysosome, and an accurate and efficient detection of H₂S within the lysosome is achieved.</p>","PeriodicalId":64,"journal":{"name":"Analytical Methods","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144482556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel MIP electrochemical sensor based on a CuFe₂O₄NPs@rGO nanocomposite and its application in breast milk samples for the determination of fipronil.","authors":"Muath Njjar, Ezgi Zekiye Aktürk, Ahmet Kaya, Canan Onac, Abdullah Akdogan","doi":"10.1039/d5ay00911a","DOIUrl":"https://doi.org/10.1039/d5ay00911a","url":null,"abstract":"<p><p><i>Background</i>: fipronil, a widely utilized insecticide in agriculture, has been shown to have potential health implications as it can accumulate in the environment and affect human health. Electrochemical sensors, specifically those incorporating molecularly imprinted polymers (MIPs), provide an efficient way for the detection of fipronil because of their selectivity and specificity. The combination of CuFe₂O₄NPs and reduced graphene oxide (rGO) exhibits a synergistic effect that enhances sensitivity and selectivity. The composite's effective properties provide a robust platform for fipronil determination in various matrices. This study detected fipronil using an electrochemical sensor based on a glassy carbon electrode (GCE) modified with MIP@CuFe₂O₄NPs@rGO. <i>Results</i>: the synthesized MIP@CuFe₂O₄NPs@rGO material was characterized using various techniques such as Fourier transform infrared (FT-IR) spectroscopy, scanning electron microscopy (FESEM), X-ray diffraction (XRD) analysis, energy dispersive X-ray (EDX) analysis, Brunauer-Emmett-Teller (BET) analysis, X-ray photoelectron spectroscopy (XPS) analysis, and electrochemical impedance spectroscopy (EIS). The modified GCE showed enhanced electrochemical behavior for fipronil, as demonstrated by cyclic voltammetry (CV) and square wave voltammetry (SWV) techniques. Optimization of parameters such as pH, pyrrole concentration, and template concentration further improved sensor performance. The sensor exhibited a linear dynamic range of 1 to 6 nM, with a limit of detection (LOD) of 0.30 nM (S/N = 3) and a limit of quantification (LOQ) of 1.08 nM (S/N = 10), highlighting its sensitivity and reliability. The precision of the method was excellent, with a relative standard deviation of less than 4.0%. When applied to quantify fipronil in breast milk samples, the sensor showed high accuracy and precision, with recoveries ranging from 96.24% to 97.75%. <i>Significance</i>: the sensor offers several advantages, including high sensitivity, specificity, and accuracy. Its ability to detect fipronil in complex matrices such as breast milk highlights its potential for real-world applications in environmental and health monitoring. Overall, this research paves the way for the development of efficient, rapid and eco-friendly sensors for detecting pesticide residues in various environmental and biological samples.</p>","PeriodicalId":64,"journal":{"name":"Analytical Methods","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144482557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}