ACS Omega最新文献

{"title":"Predictive Significance of Glycosyltransferase-Related lncRNAs in Endometrial Cancer: A Comprehensive Analysis and Experimental Validation","authors":"Xiaoyu Shen,&nbsp;Yan Liu,&nbsp;Jun Zhang,&nbsp;Ting Zhou,&nbsp;Qi Zhang,&nbsp;Kejun Dong,&nbsp;Jiarui Zhang,&nbsp;Shuangshuang Cheng,&nbsp;Tangansu Zhang,&nbsp;Guanxiao Chen,&nbsp;Shuyang Yu,&nbsp;Wan Shu* and Hongbo Wang*,&nbsp;","doi":"10.1021/acsomega.4c0907110.1021/acsomega.4c09071","DOIUrl":"https://doi.org/10.1021/acsomega.4c09071https://doi.org/10.1021/acsomega.4c09071","url":null,"abstract":"<p >Glycosylation is a crucial post-translational modification that regulates cellular functions and the surrounding microenvironment. The abnormal expression of glycosyltransferases, essential enzymes in this process, has been linked to tumor development. In addition, long noncoding RNAs (lncRNAs) have been shown to exert a multifaceted regulatory influence on gene expression. Nevertheless, research on glycosyltransferase-related lncRNAs (GTRLs) in endometrial cancer (EC) is still unclear. In this study, we constructed a novel prognostic model based on GTRLs using univariate Cox regression, Lasso, and multivariate stepwise Cox regression analysis. Our findings identified four GTRLs that were significantly associated with the prognosis of EC patients. The Kaplan–Meier (KM) survival analysis revealed a notable reduction in overall survival (OS) among high-risk populations. Furthermore, independent prognostic assessments, receiver operating characteristic (ROC) curves and nomograms, demonstrated that risk scores derived from these GTRLs outperformed other clinical variables within the TCGA-UCEC clinical data set in predicting patient prognosis. And the low-risk cohort exhibited increased immune infiltration and decreased tumor purity. Additionally, significant differences in tumor mutation profiles were observed, with the tumor mutation burden (TMB) being higher in the low-risk cohort, suggesting a potentially better response to immunotherapy. Different patient subgroups also displayed varying sensitivities to several chemotherapeutic agents. Finally, the model’s validity was confirmed through clinical specimens and in vitro experiments, which demonstrated that AC090617.5 and AP001107.9 can influence the proliferation, migratory functions, and cisplatin sensitivity of EC. Therefore, the prognostic features can effectively predict the prognosis of EC and guide therapeutic decision-making.</p>","PeriodicalId":22,"journal":{"name":"ACS Omega","volume":"10 8","pages":"8023–8041 8023–8041"},"PeriodicalIF":3.7,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acsomega.4c09071","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143533848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Papain-Catalyzed Hydrolysis of Nα-Benzoyl–arginine–p-nitroanilide in an Aqueous–Organic Medium","authors":"Jitnapa Sirirak,&nbsp;Poomipat Tamdee,&nbsp;Phanuphong Sawatthitileat,&nbsp;Jiraphon Thaithong and Nichanun Sirasunthorn*,&nbsp;","doi":"10.1021/acsomega.4c1105910.1021/acsomega.4c11059","DOIUrl":"https://doi.org/10.1021/acsomega.4c11059https://doi.org/10.1021/acsomega.4c11059","url":null,"abstract":"<p >Enzyme-based biosensors have emerged as an effective alternative, providing simplicity, high sensitivity, and the capability to detect multiple residues. However, despite their widespread use, limited studies have examined how organic solvents inhibit these sensors. This study investigates the enzymatic reactions and structure of the selected model enzyme, papain, a protease derived from <i>Carica papaya</i>, in the presence of various organic solvents. Enzyme activity was monitored through the hydrolysis of N_α-benzoyl–arginine–<i>p</i>-nitroanilide (BAPNA), with the resulting yellow product, <i>p</i>-nitroaniline, measured at a wavelength of 430 nm. The experiments incorporated a 10% (v/v) concentration of dimethyl sulfoxide (DMSO) to ensure the solubility of BAPNA. Results showed that methanol and ethanol increased the <i>K</i>_m value while causing little change in <i>V</i>_max, which negatively impacted the enzyme’s catalytic efficiency. In contrast, acetonitrile (ACN) behaved as a reversible mixed-competitive inhibitor of papain, exhibiting lower millimolar IC50 values. Furthermore, an emission maximum shift to lower wavelengths with increasing concentrations of ACN suggested that the tryptophan residues within the enzyme structure were slightly more buried. Molecular dynamics simulations of the BAPNA-papain complex in cosolvent environments containing water, DMSO, and ACN indicated that ACN could act as a mixed-competitive inhibitor alongside BAPNA and that solvent polarity could influence the binding of BAPNA to papain. These findings provide valuable insights for the application of organic solvents in biosensor technologies.</p>","PeriodicalId":22,"journal":{"name":"ACS Omega","volume":"10 8","pages":"8601–8610 8601–8610"},"PeriodicalIF":3.7,"publicationDate":"2025-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acsomega.4c11059","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143533895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Colloidal Dispersions of Gramicidin D in Water: Preparation, Characterization, and Differential Cytotoxicity","authors":"Ricardo Márcio-e-Silva,&nbsp;Bianca R. Bazan,&nbsp;Rodrigo T. Ribeiro,&nbsp;Sarah N. C. Gimenes,&nbsp;Bianca C. L. F. Távora,&nbsp;Eliana L. Faquim-Mauro and Ana M. Carmona-Ribeiro*,&nbsp;","doi":"10.1021/acsomega.4c1113310.1021/acsomega.4c11133","DOIUrl":"https://doi.org/10.1021/acsomega.4c11133https://doi.org/10.1021/acsomega.4c11133","url":null,"abstract":"<p >Gramicidin D (Gr) is a natural mixture of channel peptides A–C with minor differences in chemical structure, which are able to span cell membranes as dimers. These Gr channels allow single-file diffusion of cations, thereby disrupting the usual ionic balance in biological cells and inducing cell lysis. The microbicidal activity of Gr using different carriers such as bilayer vesicles or bilayer disks, supported bilayers on silica, or polystyrene nanoparticles has been described. Gr antimicrobial activity was found to depend strongly on its formulation. Preliminary description of self-assembled Gr nanoparticles (Gr NPs) by our group showed a superior antimicrobial performance for these Gr self-assembled nanospheres. In this work, we further characterize Gr colloidal dispersions in aqueous solution over a range of micromolar concentrations from turbidimetry, obedience to the Rayleigh law for light scattered by NPs smaller than the wavelength of the incident light, dynamic light scattering to ascertain the reproducibility of physical characteristics of Gr NPs, and effects of Gr NPs on the cell viability of five different mammalian cell lines in culture over a micromolar range of Gr concentrations (0.5–5.0 μM). Thereby, the differential cytotoxicity of Gr NPs is inferred from the comparison between effects on microbial cell viability and mammalian cell viability. The results suggest that the simple and efficacious formulation of Gr NPs obtained directly from Gr self-assembly in aqueous solution deserves to be further exploited, aiming at systemic biomedical uses of Gr in vivo against infectious diseases and cancers.</p>","PeriodicalId":22,"journal":{"name":"ACS Omega","volume":"10 8","pages":"8611–8618 8611–8618"},"PeriodicalIF":3.7,"publicationDate":"2025-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acsomega.4c11133","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143533842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cobalt-Doped Nickel Hydroxide on Polyaniline-Decorated Nickel Foam for Enhanced Performance of the Oxygen Evolution Reaction","authors":"Dawit Tibebu Haile,&nbsp;Munise Cobet,&nbsp;Christoph Ulbricht,&nbsp;Felix Mayr,&nbsp;Elisabeth Leeb,&nbsp;Cigdem Yumusak,&nbsp;Bekele Hailegnaw,&nbsp;Teketel Yohannes,&nbsp;Niyazi Serdar Sariciftci and Getachew Adam Workneh*,&nbsp;","doi":"10.1021/acsomega.4c0696610.1021/acsomega.4c06966","DOIUrl":"https://doi.org/10.1021/acsomega.4c06966https://doi.org/10.1021/acsomega.4c06966","url":null,"abstract":"<p >In this research, cobalt-doped Ni(OH)₂ on a PANI-decorated NF substrate is prepared via an electrochemical method. The surface characteristics, roughness, chemical composition, and crystalline structure of the prepared materials are described using scanning electron microscopy (SEM), atomic force microscopy (AFM), energy dispersive spectroscopy (EDS), X-ray photoelectron spectroscopy (XPS), and X-ray diffraction (XRD), in that order. Further, optical characterization techniques of attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR) and Raman spectroscopy are used for confirmation of the polymerization of PANI. The results reveal that PANI and bimetallic oxide/hydroxide agglomerate on the bare NF’s flat skeleton. The electrocatalytic performance of Co–Ni(OH)₂/PANI-NF for the oxygen evolution reaction (OER) in alkaline media is carried out, and it demonstrates outstanding electrocatalytic activity, exhibiting an overpotential of 180 mV@20 mA cm^–2 with a Tafel slope of 62 mV dec^–1. The TOF (10^–2) value is determined to be 2.49 s^–1 at 1.58 V, highlighting the elevated intrinsic activity of Co–Ni(OH)₂/PANI-NF in catalyzing the OER. The stability testing using chronoamperometry (CA) for 24 h to accomplish 100 mA cm^–2 and cyclic voltammetry (CV) for 200 cycles with a scan rate of 5 mV s^–1. The results demonstrate that the material maintains its electrochemical performance and structural integrity even after prolonged exposure to these conditions. These findings highlight that Co–Ni(OH)₂/PANI-NF is an effective and promising electrocatalytic material for the OER, potentially advancing the efficiency of hydrogen production through water electrolysis.</p>","PeriodicalId":22,"journal":{"name":"ACS Omega","volume":"10 8","pages":"7648–7661 7648–7661"},"PeriodicalIF":3.7,"publicationDate":"2025-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acsomega.4c06966","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143533899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PARP2 Catalytic Activity Is Allosterically Stimulated by Binding to the c-KIT1 G-Quadruplex","authors":"Dagur Singh Hanuman,&nbsp;Singh Neeharika and Eerappa Rajakumara*,&nbsp;","doi":"10.1021/acsomega.5c0072410.1021/acsomega.5c00724","DOIUrl":"https://doi.org/10.1021/acsomega.5c00724https://doi.org/10.1021/acsomega.5c00724","url":null,"abstract":"<p >PARP2, along with PARP1, is involved in the maintenance of the genomic stability. PARP2 catalyzes the formation of poly(ADP-ribose) to recruit repair proteins at the site of DNA breaks. Single-strand (SSB) and double-strand (DSB) DNA breaks are bona fide stimulators of PARP2 catalytic activity. However, the regulation of PARP2 catalytic activity by G-quadruplex DNA structures, abundant in regulatory and promoter regions of proto-oncogene and telomeres, has not been studied. Here, we report that PARP2 binds to the proto-oncogene-specific parallel G-quadruplex, c-KIT1-G4. c-KIT1-G4 stimulates the catalytic activity of PARP2. However, the c-KIT1-G4-dependent stimulation of PARP2 catalytic activity is 2-fold lesser than 5′P-SSB DNA, a cognate stimulator of PARP2 catalytic activity. The N-terminal region of PARP2 is dispensable for c-KIT1-G4 DNA-dependent self-PARylation catalytic activity but contributes to the c-KIT1-G4 DNA binding affinity of PARP2 along with the WGR domain. Altogether, our work reveals that PARP2 selectively binds to a higher-order DNA structure and is allosterically activated.</p>","PeriodicalId":22,"journal":{"name":"ACS Omega","volume":"10 8","pages":"8767–8776 8767–8776"},"PeriodicalIF":3.7,"publicationDate":"2025-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acsomega.5c00724","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143533900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis, Structural Characterization, and Magnetic Properties of Two New Fe(III)Mn(III) 1D Bimetallic Compounds","authors":"Abdelwahab Hassan*,&nbsp;Eslam Hemida,&nbsp;Nada I. Mahmoud,&nbsp;Mohamed Kamel,&nbsp;Hany M. Elsharkawy,&nbsp;Ahmed S. G. Khalil,&nbsp;Mahmoud Abdel-Hafiez* and Mohamed R. Saber*,&nbsp;","doi":"10.1021/acsomega.4c0988710.1021/acsomega.4c09887","DOIUrl":"https://doi.org/10.1021/acsomega.4c09887https://doi.org/10.1021/acsomega.4c09887","url":null,"abstract":"<p >Two Fe(III)Mn(III) bimetallic compounds, [Tp*Fe (CN)₃][(Mn^IIIsalen)]·MeOH·MeCN (<b>1</b>) and [Tp*Fe (CN)₃][Mn^IIIsalphen]·MeOH·H₂O (<b>2</b>), were prepared by assembling the tricyanometalate building block (TEA)₄N [Tp*Fe(CN)₃] [Tp* = hydrotris(3,5-dimethylpyrazol-1-yl)borate] and the respective Mn Schiff base precursors [salen = <i>N</i>,<i>N</i>′-ethylenebis(salicylideneiminate), salphen = <i>N</i>,<i>N</i>-bis(salicylidene)-1,2-phenylenediamine]. Both compounds exhibit a one-dimensional (1D) zigzag chain structure linked by cyanide bridges, forming a (−Fe–C≡N–Mn–N≡C−)<i>_n</i> motif. Magnetic studies show a gradual increase of χ_M<i>T</i> values in both complexes upon lowering temperature, indicating ferromagnetic coupling between the Fe^III and Mn^III metal centers with Curie–Weiss constants of +1.1 K in (<b>1</b>) and +1.0 K in (<b>2</b>). Ferromagnetic interactions are attributed to the significantly bent Mn–NC angles (148.52 and 152.99° for (<b>1</b>) and 154.9 and 151.3° for (<b>2</b>)). The formation of 1D chains in the presence of MeOH challenges earlier reports that linked chain formation to the absence of MeOH in the reaction medium. This finding highlights the highly sensitive nature of this reaction system to various factors, including the influence of solvents on intermolecular interactions, the coordinative properties and polarity of the solvent, the steric and electronic characteristics of the precursors, and specific reaction conditions, such as temperature, concentration, and molar ratios.</p>","PeriodicalId":22,"journal":{"name":"ACS Omega","volume":"10 8","pages":"8271–8280 8271–8280"},"PeriodicalIF":3.7,"publicationDate":"2025-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acsomega.4c09887","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143533901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Simulation and Analysis of a Novel Hydrogen Liquefaction Process Based on the Liquid Nitrogen and Helium Joule–Brayton Cycle","authors":"Wenhao Song*,&nbsp;Ke Liu,&nbsp;Zhonghua Zhao,&nbsp;Limeng Zhang,&nbsp;Xinguang Dong,&nbsp;Xingsen Yang,&nbsp;Chunxiao Tian,&nbsp;Shuai Liu and Shuo Cao,&nbsp;","doi":"10.1021/acsomega.4c0929910.1021/acsomega.4c09299","DOIUrl":"https://doi.org/10.1021/acsomega.4c09299https://doi.org/10.1021/acsomega.4c09299","url":null,"abstract":"<p >To facilitate the design, analysis, and optimization of the hydrogen liquefaction system, this study developed a MATLAB-based independent simulation program encompassing unit equipment models and exergy analysis models. The program incorporated REFPROP software to accurately calculate fluid physical properties and the heat of conversion between ortho- and parahydrogen. The proposed hydrogen liquefaction process utilized LN₂ precooling, the helium Joule–Brayton cryogenic cycle, and a throttle valve to efficiently produce liquid hydrogen. The simulation results were rigorously validated using the industry standard Unisim Design software. For the 0.5 t/d hydrogen liquefaction system, the exergy efficiency stood at 28.82%, accompanied by a specific energy consumption of 9.82 kW h/kg_LH2. Notably, the compressor contributed the highest exergy loss ratio, accounting for 38.79% of the total. Increasing the compressor efficiency could significantly improve the exergy efficiency and reduce energy consumption. A comparative analysis revealed that at a larger scale of 50 t/d, the exergy losses of both the compressor and expander decreased, whereas the heat exchanger accounted for 36.29% of the total. In conclusion, the independent simulation program established in this study served as a valuable tool for simulating and analyzing the hydrogen liquefaction system, providing a crucial reference for design improvements and optimization efforts.</p>","PeriodicalId":22,"journal":{"name":"ACS Omega","volume":"10 8","pages":"8089–8102 8089–8102"},"PeriodicalIF":3.7,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acsomega.4c09299","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143533767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utilizing Block Copolymer Films as an Etch Mask for Pattern Transfer","authors":"Chang Eon Kim,&nbsp;Jae Won Shim,&nbsp;Seok Jun Ham and Seung Hyun Kim*,&nbsp;","doi":"10.1021/acsomega.4c1093510.1021/acsomega.4c10935","DOIUrl":"https://doi.org/10.1021/acsomega.4c10935https://doi.org/10.1021/acsomega.4c10935","url":null,"abstract":"<p >Micro- and nanopatterned surfaces are highly useful as functional surfaces and in the fabrication of electronic and optical devices. Transferring high-resolution patterns into a photoresistive layer or the substrate surface is a crucial step in fabricating a nanostructure with gratings, pillar arrays, and hole arrays. In this work, a very simple yet efficient and high-throughput route for pattern transfer was investigated based on the self-assembly of block copolymers (BCPs). The high etch contrast and high density of the periodic pillar array require a vertically oriented structure of the cylinder-forming BCP. Solvent-vapor annealing under fine-tuned conditions allowed us to control the orientation of the BCP microdomains relative to the surface. Liquid-phase infiltration (LPI) of metal ions of Au, Pt, and Pd into the BCP domains effectively enhanced the etch contrast for pattern transfer. By investigating the conditions of the LPI and etching processes, it was found that the nanopatterns from BCP templates were successfully transferred into the SiO₂ layer on wafers with a high aspect ratio of pillars. It was also shown that this process can be applied to the Si₃N₄ substrate and that more diverse and complex patterns can be transferred via BCP blends. Through this work, it was demonstrated that BCP assembly combined with the LPI process can be a highly efficient and versatile route to pattern transfer with high resolution and throughput.</p>","PeriodicalId":22,"journal":{"name":"ACS Omega","volume":"10 8","pages":"8579–8587 8579–8587"},"PeriodicalIF":3.7,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acsomega.4c10935","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143533820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sustainable Enhanced Oil Recovery Fluid Based on Synergic Effects of Cationic, Anionic, and Nonionic Surfactants in Low Salinity: SLS; QA; and SDBS","authors":"Cristina M. Quintella*,&nbsp;Pamela Dias Rodrigues,&nbsp;Samira Abdallah Hanna,&nbsp;Jorge Luis Nicoleti,&nbsp;Edgard Bacic Carvalho,&nbsp;Ana Claudia Gondim de Medeiros,&nbsp;Elias Ramos-de-Souza,&nbsp;Elias Silva dos Santos,&nbsp;Anaís Couto Vasconcelos,&nbsp;Juliana Dias de Moura,&nbsp;Eloísa Vitória Almeida de Oliveira Santos,&nbsp;Matheus de Oliveira Gama and Vitor Cerqueira Morais,&nbsp;","doi":"10.1021/acsomega.4c1008910.1021/acsomega.4c10089","DOIUrl":"https://doi.org/10.1021/acsomega.4c10089https://doi.org/10.1021/acsomega.4c10089","url":null,"abstract":"<p >In the context of the energy transition, petroleum will remain a critical resource for several decades. Enhanced oil recovery (EOR) offers a method for optimizing its production while advancing the United Nations Sustainable Development Goal 12 (SDG 12) and the 2030 Agenda, which emphasize reducing the environmental impact and addressing community concerns. Pre-salt limestone reservoirs, situated far offshore, require customized enhanced oil recovery (EOR) strategies. Although low salinity water has recently gained attention for these reservoirs, further investigation is required to integrate environmentally low-impact surfactants and to minimize their concentrations while maintaining high recovery factors (RFs). Low salinity water formulations containing small concentrations of surfactants were injected into limestone core samples with oil from presalt reservoirs under reservoir conditions. In total, 21 linear formulations and 16 multivariate formulations experimentally designed using Doehlert matrix as the chemometric tool were prepared by combining the nonionic surfactant sodium dodecylbenzenesulfonate (SDBS), the anionic surfactant sodium lauryl sulfate (SLS), and the cationic surfactant tetraethylammonium chloride (QA) at concentration levels above, below, and on their respective critical micelle concentrations (CMCs). The produced water was analyzed using X-ray fluorescence, with spectra evaluated via principal component analysis (PCA) and partial least squares (PLS). Theoretical simulations were also performed with molecular dynamics applied to the two top-performing results. The traditional linear study, varying individual surfactant concentrations, yielded an RF increase of up to 12.8%. However, the covariation approach further improved the results, achieving an RF of 16%, primarily due to the synergistic effects of the cationic and anionic surfactants, which mobilized both bulk oil and surface oil. The balance among micellar SLS, micellar SDBS, and nonmicellar QA proved essential. Theoretical simulations supported these experimental findings, indicating no direct interaction between the surfactants, increased interfacial tension, SLS migration to the surface, and QA retention in the bulk phase.</p>","PeriodicalId":22,"journal":{"name":"ACS Omega","volume":"10 8","pages":"8408–8419 8408–8419"},"PeriodicalIF":3.7,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acsomega.4c10089","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143533765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multi-Microseconds Microbubbles Induced by Nanoseconds Pulsed-Laser Heating of Gold Nano-Particles","authors":"Mohammad Amer Allaf*,&nbsp;Koji Okamoto and Takuto Owa,&nbsp;","doi":"10.1021/acsomega.4c1032810.1021/acsomega.4c10328","DOIUrl":"https://doi.org/10.1021/acsomega.4c10328https://doi.org/10.1021/acsomega.4c10328","url":null,"abstract":"<p >This study examines the effect of gold-nanoparticles (GNPs) aggregation on the formation of multimicrosecond water-vapor (WV) microbubbles (MBs) generated by nanosecond pulsed-laser heating of GNPs in water. The MBs’ dynamics reveal a “dual-nature” system involving both WV phase change and the release of dissolved gases (DGs). High-speed visualization (216 kfps) captures two distinct stages in the MB lifecycle: an initial fast growth-collapse of the WV phase (multimicrosecond duration), followed by a slow collapse driven by DG release (&gt;milliseconds). A double-exponential function effectively captures these stages, distinguishing WV and DG contributions. The prolonged WV lifetime, which differs significantly from previously reported nanosecond-scale lifetime, is strongly influenced by aggregation effects. This is supported by numerical-modeling of the heat diffusion around a plasmonically heated GNP, where aggregation is assumed to occur prior to the pulsed-laser application. Besides, a correlation found to exist between the WV’s lifetime and the DGs’ contribution to the overall MBs, the larger the DGs’ contribution, the shorter the lifetime of the WV is, which is found to be driven by the increasing likelihood of aggregation. In summary, aggregation can either enhance or suppress plasmonic bubble generation and influence the WV lifetime or DG release. This work demonstrates the feasibility of multimicrosecond WV-MBs, which potentially can offer an extended operational window for various applications, including imaging, diagnostics, and therapeutics, and microfluidic technologies.</p>","PeriodicalId":22,"journal":{"name":"ACS Omega","volume":"10 8","pages":"8398–8407 8398–8407"},"PeriodicalIF":3.7,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acsomega.4c10328","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143533581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}