IF 6.7 3区材料科学

Nanoscale Pub Date : 2025-10-02 DOI: 10.1039/d5nr02634b

Arunjegan Amalraj, Ravikumar Ayyanu, Ming Li, Yanqiu Jiang, Komal Murugan, Emmanuel Chigozie Aham, Zhen Zhang, Hongjun Zhao

{"title":"A Review on Multi-Enzyme Activity of ZIF, PBA, PCN and MIL MOF-Derived Cascade Nano-Enzymes for Catalytic Applications","authors":"Arunjegan Amalraj, Ravikumar Ayyanu, Ming Li, Yanqiu Jiang, Komal Murugan, Emmanuel Chigozie Aham, Zhen Zhang, Hongjun Zhao","doi":"10.1039/d5nr02634b","DOIUrl":"https://doi.org/10.1039/d5nr02634b","url":null,"abstract":"Metal-organic frameworks (MOFs) with multiple enzyme-like activities termed multienzyme mimetic catalysts have emerged as powerful candidates for diverse catalytic applications, particularly in biosensing and biomedicine. Unlike single-enzyme nanozymes, these multienzyme MOF-based catalysts offer enhanced catalytic efficiency through synergistic effects, cascade reactions, and dynamic responsiveness to environmental stimuli. Among them, four classes zeolitic imidazolate frameworks (ZIFs), porous coordination networks (PCNs), Prussian blue analogs (PBAs), and Materials of Institut Lavoisier (MILs) have shown exceptional promise due to their structural tunability and catalytic versatility. This review provides a comprehensive overview of multienzyme-like activity in these MOFs, including advances in metal doping, biomolecule incorporation, MOF-on-MOF architectures, carbonization strategies, and MOF-derived nanozymes. We explore the underlying catalytic mechanisms and discuss recent strategies to modulate and enhance their enzyme-mimicking behavior. Special emphasis is placed on applications in sensing and therapy, including toxic metal, gas, and biomolecule detection, antibacterial activity, wound healing, tumor therapy, photothermal treatment, chemotherapy, and reactive oxygen species/ reactive nitrogen species (ROS/RNS) scavenging. A critical analysis reveals that while ZIF, PCN, PBA, and MIL-based MOFs show great promise, most studies remain at proof-of-concept with limited clinical translation. It provides a unified perspective to guide the rational design and implementation of multienzyme MOFs in next-generation biomedical and sensing technologies.","PeriodicalId":92,"journal":{"name":"Nanoscale","volume":"99 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145203491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanozyme-Driven Remodeling of the Immune Microenvironment: From Catalytic Therapy to Precise Immune Regulation 纳米酶驱动的免疫微环境重塑：从催化治疗到精确免疫调节

IF 6.7 3区材料科学

Nanoscale Pub Date : 2025-10-02 DOI: 10.1039/d5nr03420e

Qian He, Liyun Zhang

{"title":"Nanozyme-Driven Remodeling of the Immune Microenvironment: From Catalytic Therapy to Precise Immune Regulation","authors":"Qian He, Liyun Zhang","doi":"10.1039/d5nr03420e","DOIUrl":"https://doi.org/10.1039/d5nr03420e","url":null,"abstract":"Nanozymes have emerged as transformative tools for addressing critical challenges in diseases characterized by immune dysregulation, including cancer, chronic inflammation, and persistent infections. These enzyme-mimicking nanomaterials offer unique advantages in remodeling pathological immune microenvironments through their tunable catalytic activities and precise spatiotemporal control. This review systematically examines recent breakthroughs in nanozyme-based immunomodulation, highlighting their ability to induce immunogenic cell death and activate innate immune pathways in cancer therapy, simultaneously scavenge reactive species and reprogram macrophage polarization in inflammatory diseases, and disrupt microbial biofilms while resolving infection-associated immunosuppression. We critically analyze key innovations in single-atom catalysts, bioinspired delivery systems, and novel catalytic-immune mechanisms that enable targeted immune regulation. By elucidating fundamental structure-activity relationships and translational challenges, this review provides valuable insights for developing next-generation nanozyme immunotherapies with enhanced specificity and clinical potential. These advances establish nanozymes as powerful platforms for precision immunotherapy across a broad spectrum of immune-related disorders.","PeriodicalId":92,"journal":{"name":"Nanoscale","volume":"39 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145203495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Silver-decorated boron nitride nanocomposite-infused cotton fabric with durable antimicrobial and multifunctional properties 银装饰氮化硼纳米复合注入棉织物，具有耐用，抗菌和多功能特性

IF 6.7 3区材料科学

Nanoscale Pub Date : 2025-10-02 DOI: 10.1039/d5nr02267c

Swati Bishnoi, Gulshitab Aalam, Tariq Ahmad Mir, S. Wazed Ali, Sudip K. Pattanayek

{"title":"Silver-decorated boron nitride nanocomposite-infused cotton fabric with durable antimicrobial and multifunctional properties","authors":"Swati Bishnoi, Gulshitab Aalam, Tariq Ahmad Mir, S. Wazed Ali, Sudip K. Pattanayek","doi":"10.1039/d5nr02267c","DOIUrl":"https://doi.org/10.1039/d5nr02267c","url":null,"abstract":"The textile industry is rapidly evolving to meet growing consumer demands for advanced, functional products. While traditional textiles have improved in mechanical strength, durability, and attributes like flame retardancy, cotton fabrics remain vulnerable to microbial degradation due to moisture retention. This study presents a novel approach that utilizes boron nitride (BN) and silver nanoparticles (Ag NPs) to impart antimicrobial properties to cotton fabrics. Silver-decorated BN (BN-Ag) was synthesized and functionalized with carboxyl groups, enabling strong ester bond formation with cotton cellulose, significantly enhancing antimicrobial efficacy against Gram-positive Staphylococcus aureus (S. aureus, 99.57%) and Gram-negative Escherichia coli (E. coli, 99.64%). The BN-Ag treated fabric exhibited impressive antioxidant activity (51.78%) and ultraviolet (UV) protection (98.39% for UVA and 98.4% for UVB), surpassing untreated cotton. Furthermore, thermal resistance was reduced by 21.23%, indicating improved heat dissipation for smart textile applications. UV protection factor (UPF) analysis classified BN-Ag fabrics as excellent UV protectors (UPF 62.56). Long-term stability assessments revealed that the fabrics maintained antimicrobial efficacy (97.61% against S. aureus and 97.11% against E. coli) and antioxidant activity (43.73%) after six months with 20 home washes, demonstrating the durability of functional properties. This innovative approach promises to revolutionize textile materials, enhancing properties and performance for diverse applications.","PeriodicalId":92,"journal":{"name":"Nanoscale","volume":"29 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145203497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent progress on synthesis of CuCr2O4 nanomaterials and its composites for catalytic, energy, and biomedical applications: A state-of-the-art-review 催化、能源和生物医学用CuCr2O4纳米材料及其复合材料的合成研究进展

IF 6.7 3区材料科学

Nanoscale Pub Date : 2025-10-02 DOI: 10.1039/d5nr03084f

Kajalben Patel, Mamta Patil, Yogita Abhale, Kun-Yi Andrew Lin, Kar Ban Tan, Ankush Chauhan, Abhinav Kumar, Vishnu Adole, Majid S. Jabir, Suresh Ghotekar

{"title":"Recent progress on synthesis of CuCr2O4 nanomaterials and its composites for catalytic, energy, and biomedical applications: A state-of-the-art-review","authors":"Kajalben Patel, Mamta Patil, Yogita Abhale, Kun-Yi Andrew Lin, Kar Ban Tan, Ankush Chauhan, Abhinav Kumar, Vishnu Adole, Majid S. Jabir, Suresh Ghotekar","doi":"10.1039/d5nr03084f","DOIUrl":"https://doi.org/10.1039/d5nr03084f","url":null,"abstract":"Copper chromite nanoparticles (CuCr2O4 NPs) are in the spotlight of modern nanoscience due to their versatile applications across various scientific and industrial domains. This review addresses the synthesis of CuCr2O4 NPs, metal-doped CuCr2O4 NPs, and nanocomposites (NCs), emphasizing the key parameters, viz., reaction time, pH, temperature, precursor concentration, and the choice of fuel or surfactant that influence their morphology, crystallinity, and functional properties. CuCr2O4 NPs are fabricated using several chemical methods, namely sol-gel, co-precipitation, hydrothermal, solution combustion, ball-milling, and many more, with different types of fuels or surfactants serving as complexing agents. These materials exhibit remarkable thermal, electrical, and catalytic characteristics. The discussion extends to their broad spectrum of applications, including biological activities such as antimicrobial, anticancer, and bone regeneration, as well as their genotoxic impact. We also explore their role in photocatalysis, heterogeneous catalysis, and electrochemical applications, including supercapacitors and lithium-ion batteries. The emerging utility of CuCr2O4 NPs in sensor development is also highlighted. This review paper covers the recent advancements in the synthesis of CuCr2O4 NPs, highlighting key challenges and future directions. Analyzing the structure-property relationships and the influence of synthesis parameters on performance provides valuable insights for optimizing the design and functionalization of CuCr2O4 NPs for specific applications.","PeriodicalId":92,"journal":{"name":"Nanoscale","volume":"5 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145203548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction: WS2 nanosheet as a new photosensitizer carrier for combined photodynamic and photothermal therapy of cancer cells 修正：WS2纳米片作为一种新型光敏剂载体用于光动力和光热联合治疗癌细胞

IF 6.7 3区材料科学

Nanoscale Pub Date : 2025-10-02 DOI: 10.1039/d5nr90201k

Yuan Yong, Liangjun Zhou, Zhanjun Gu, Liang Yan, Gan Tian, Xiaopeng Zheng, Xiaodong Liu, Xiao Zhang, Junxin Shi, Wenshu Cong, Wenyan Yin, Yuliang Zhao

引用次数: 0

Sub-5 nm monolayer SnNX (X=Cl, Br)-based homogeneous CMOS devices 亚5nm单层SnNX （X=Cl, Br）基均质CMOS器件

IF 6.7 3区材料科学

Nanoscale Pub Date : 2025-10-02 DOI: 10.1039/d5nr03257a

Yandong Guo, Zhipeng Huan, Yuting Guo, Man-Jun Jiang, Yue Jiang, Jie-Ling Hu, Liyan Lin, Hong-Li Zeng, Xiaohong Yan

{"title":"Sub-5 nm monolayer SnNX (X=Cl, Br)-based homogeneous CMOS devices","authors":"Yandong Guo, Zhipeng Huan, Yuting Guo, Man-Jun Jiang, Yue Jiang, Jie-Ling Hu, Liyan Lin, Hong-Li Zeng, Xiaohong Yan","doi":"10.1039/d5nr03257a","DOIUrl":"https://doi.org/10.1039/d5nr03257a","url":null,"abstract":"For next-generation CMOS electronics beyond silicon, the pursuit of channel materials capable of achieving symmetrical performance for n-and p-type devices, while supporting extreme device scaling, is of fundamental importance. Monolayer SnNX (X=Cl, Br) emerges as a promising candidate, owing to its atomically thin structure and high carrier mobilities for both electrons and holes. Using first-principles calculations, the performance limits of sub-5-nm-L g double-gated monolayer SnNX (X=Cl, Br) metal-oxide semiconductor field-effect transistors (MOSFETs) are explored. It is found that SnNX MOSFETs can meet the International Technology Roadmap for Semiconductors (ITRS) 2028 requirements for both high-performance (HP) and lowpower (LP) applications, even at a reduced L g of 3 nm. Notably, the n-type SnNX MOSFETs with L g =5 nm exhibit ultra-high ON-state currents, even reaching 4533 µA/µm, which surpass most reported monolayer MOSFETs. In addition, the key performance metrics, i.e., ON-state current, subthreshold swing, delay time, fringe capacitance and power-delay product, exhibit high symmetry between n-and p-type devices. These findings highlight the potential of monolayer SnNX (X=Cl, Br) as next-generation channel materials for building CMOS integrated circuits in the post-silicon era.","PeriodicalId":92,"journal":{"name":"Nanoscale","volume":"22 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145203492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Polarization-Sensitive Photodetector Based on b-AsP/In2Se3 Heterostructure 基于b-AsP/In2Se3异质结构的偏振敏感光电探测器

IF 6.7 3区材料科学

Nanoscale Pub Date : 2025-10-02 DOI: 10.1039/d5nr02575c

Le Ju, Binqian Zou, Suofu Wang, Tao Han, Feng Li, Xinyuan Hou, Min Zhang, Fei Ding, Lei Shan, Mingsheng Long

{"title":"Polarization-Sensitive Photodetector Based on b-AsP/In2Se3 Heterostructure","authors":"Le Ju, Binqian Zou, Suofu Wang, Tao Han, Feng Li, Xinyuan Hou, Min Zhang, Fei Ding, Lei Shan, Mingsheng Long","doi":"10.1039/d5nr02575c","DOIUrl":"https://doi.org/10.1039/d5nr02575c","url":null,"abstract":"Van der Waals (vdW) heterojunctions, composed of two-dimensional materials, offer competitive opportunities in the design and realization of versatile and high-performance electronic and optoelectronic devices. Polarization-sensitive infrared (IR) photoelectric detection plays an important role in optical communication, environmental monitoring, and remote sensing imaging. Here, we report a mirror electrode-enhanced black arsenic phosphorus (b-AsP) and indium selenide (In2Se3) b-AsP/In2Se3 vdW heterojunction photodetector. The device enables wide-band detection from the solar-blind ultraviolet (SBUV) to the mid-wave infrared (MWIR) spectral range. The excellent performance of the device, including a high photoresponsivity (R) of 4129.3 AW-1, competitive high specific detectivity (D*) of 2.8×1011 cmHz1/2W-1, and very low noise equivalent power (NEP) of 2.8×10-15 WHz−1/2 with 275 nm SBUV light at 1 V bias. Moreover, the device demonstrated a very fast speed with a rise time (τr) of 5.8 μs, decay time (τd) of 2.8 μs, and a high dichroic ratio of ~2.12 with a 637 nm laser. This work provides a way to realize polarization-sensitive detectors with high sensitivity and fast speed.","PeriodicalId":92,"journal":{"name":"Nanoscale","volume":"114 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145203493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhanced stretchability and stability of micro hole mesh electrodes via a crack-guiding notch design 微孔网电极的可拉伸性和稳定性通过裂缝引导缺口设计

IF 6.7 3区材料科学

Nanoscale Pub Date : 2025-10-02 DOI: 10.1039/d5nr02993g

Wentao Qian, Le Weng, Junzhuan Wang, Linwei Yu

{"title":"Enhanced stretchability and stability of micro hole mesh electrodes via a crack-guiding notch design","authors":"Wentao Qian, Le Weng, Junzhuan Wang, Linwei Yu","doi":"10.1039/d5nr02993g","DOIUrl":"https://doi.org/10.1039/d5nr02993g","url":null,"abstract":"The rapid development of flexible devices demands higher stretchability and stability in conductive metal electrodes, which are indispensable components in a wide range of flexible technologies. In this work, we propose and demonstrate a novel hole mesh structure featuring a directional crack-guiding notch (CGN) design, which can help to disperse stretching stress/strain, while effectively confining cracks to pre-notched locations, minimizing harm to the structural continuity and electrical conductivity of the electrode film. As a proof of concept, hole mesh thin films (Pt/Au) with the CGN design were fabricated and transferred directly onto the elastic polymer substrate (polydimethylsiloxane, PDMS) and tested under repetitive stretching. It is found that the hole mesh electrodes, with CGN design, demonstrate significantly enhanced stretchability and excellent stability of conductivity, withstanding up to 20% strain for 170 cycles—a remarkable improvement compared to the reference samples without notches, which typically fail at lower strains. Further finite element simulations further reveal that the crack-guiding notches effectively suppress uncontrolled crack propagation through the whole mesh electrode, releasing accumulated strain only at the predefined notched locations in a well-controlled manner, and thus maintaining the overall conductivity of the hole mesh electrodes. This very convenient but effective CGN design holds great promise for broad applications in stretchable electronics, sensors, and displays.","PeriodicalId":92,"journal":{"name":"Nanoscale","volume":"204 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145203494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

One step construction of Mesh-like CoSe2 microflowers for magnesium-lithium hybrid batteries with enhanced rate performance 提高倍率性能的镁锂混合电池网状CoSe2微花的一步构建

IF 6.7 3区材料科学

Nanoscale Pub Date : 2025-10-02 DOI: 10.1039/d5nr02865e

Wutao Wei, Zhikai Wang, Peng Xue, Zhao Liu, Xi Jia, Yanjie Wang, Fang He, Liwei Mi

引用次数: 0

Application of carbon quantum dots in smart polymer films for biomedical diagnostics 碳量子点在生物医学诊断智能聚合物薄膜中的应用

IF 6.7 3区材料科学

Nanoscale Pub Date : 2025-10-02 DOI: 10.1039/d5nr02878g

Anna Piasek, Jolanta Pulit-Prociak

{"title":"Application of carbon quantum dots in smart polymer films for biomedical diagnostics","authors":"Anna Piasek, Jolanta Pulit-Prociak","doi":"10.1039/d5nr02878g","DOIUrl":"https://doi.org/10.1039/d5nr02878g","url":null,"abstract":"In the era of personalized medicine and wearable technologies, there is a growing demand for flexible, biocompatible, and highly sensitive sensors capable of continuous biomarker monitoring directly on the skin surface. Carbon quantum dots (CQDs), due to their unique fluorescent properties, non-toxicity, and ease of functionalization, represent an attractive active component in the design of such devices. Depending on the polymer matrix and integration strategy, polymer-CQDs composites can operate via optical or electrochemical mechanisms, which significantly broadens their biomedical applications. This review article discusses the mechanisms of CQDs integration with polymer matrices, such as chemical and physical immobilization, crosslinking, and the formation of layered composites. Special attention is given to conductive polymers, hydrogels, and biodegradable polymers that serve structural, sensory, and protective functions. Current applications of such materials are presented, including smart wound dressings, microneedle devices, and wearable devices such as smartbands. The mechanisms of biomarker detection and electrical conduction in CQD-based systems are also characterized, and technological challenges such as selectivity, integration with electronics, and power supply are analyzed. The article also outlines future development directions for these technologies, considering energy autonomy, biodegradability, sensor personalization, and data management. The aim of the work is to provide a comprehensive analysis of the current state of knowledge in the design of functional polymer-CQDs composite materials for applications in modern skin-integrated bioelectronics for medical diagnostics.","PeriodicalId":92,"journal":{"name":"Nanoscale","volume":"101 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145203824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanoscale最新文献