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Visual behaviour in acute stress during simulated and on-road driving. 模拟和公路驾驶急性应激下的视觉行为。
IF 3.7 4区 心理学
Stress-The International Journal on the Biology of Stress Pub Date : 2027-12-31 Epub Date: 2026-10-21 DOI: 10.1080/10253890.2026.2739892
Anastasiia Bakhchina, Karina Arutyunova, Evgenii Burashnikov, Nikita Timakin, Andrei Filimonov, Ivan Shishalov
{"title":"Visual behaviour in acute stress during simulated and on-road driving.","authors":"Anastasiia Bakhchina, Karina Arutyunova, Evgenii Burashnikov, Nikita Timakin, Andrei Filimonov, Ivan Shishalov","doi":"10.1080/10253890.2026.2739892","DOIUrl":"https://doi.org/10.1080/10253890.2026.2739892","url":null,"abstract":"<p><p>Driving frequently exposes individuals to conditions triggering acute stress, but its effects on drivers' visual behaviour remain insufficiently understood. We used the heart rate dynamics to label acute stress episodes in recordings from 881 participants who performed simulated and on-road driving. Considering acute stress as a phased process, we analysed eye gaze metrics during stress activation and stress resistance periods. In simulation, stress activation was accompanied by more frequent and shorter fixations, greater fixation area, higher stationary gaze entropy, and lower gaze transition entropy. In on-road driving, significant effects were more selective, with the most consistent changes observed for the horizontal diameter of fixation area and entropy-based gaze measures. During stress resistance, many measures partially returned toward non-stress levels, suggesting a transition from initial reactivity toward stabilisation. These findings support gaze-derived measures as candidate indicators of changes in visual behaviour related to acute stress during driving, while highlighting the importance of considering acute stress as a phased process. They also indicate that multimodal context-aware validation is needed for translation into real-time driver state monitoring and safety-relevant assistance applications.</p>","PeriodicalId":51173,"journal":{"name":"Stress-The International Journal on the Biology of Stress","volume":"30 1","pages":"2739892"},"PeriodicalIF":3.7,"publicationDate":"2027-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149240233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Salivary oxytocin and testosterone in empathic stress responding: a pilot study. 唾液催产素和睾酮在共情应激反应中的初步研究。
IF 3.7 4区 心理学
Stress-The International Journal on the Biology of Stress Pub Date : 2027-12-31 Epub Date: 2026-10-09 DOI: 10.1080/10253890.2026.2720481
Katja Heilmann, Martin Walter, Veronika Engert
{"title":"Salivary oxytocin and testosterone in empathic stress responding: a pilot study.","authors":"Katja Heilmann, Martin Walter, Veronika Engert","doi":"10.1080/10253890.2026.2720481","DOIUrl":"https://doi.org/10.1080/10253890.2026.2720481","url":null,"abstract":"<p><p>Suffering the stress of others (termed empathic stress or stress contagion) may affect an individual's health and well-being. To understand the underlying hormonal processes of empathic stress, <i>N</i> = 108 opposite-sex dyads were tested, with one dyad partner passively observing the other undergoing a standardized psychosocial laboratory stressor. A positive link between oxytocin release and empathic stress response was hypothesized, while a negative relationship was expected for testosterone release. Associations of observer oxytocin and testosterone levels with two components of empathic stress were examined: stress resonance (i.e. synchronized observer-target responses) and vicarious stress (observer responses independent of target stress). During the passive observation of a stressed target, salivary oxytocin and testosterone levels increased by 16.64% and 23.00%, respectively, followed by a drop back to baseline levels. Supporting our hypotheses, increased observer oxytocin reactivity was linked to greater stress resonance in HF-HRV reactivity. This association was reversed in low oxytocin responders. Further, testosterone reactivity was negatively associated with stress resonance in heart rate activity. However, testosterone also showed a positive association with vicarious cortisol activity, which resembles the response pattern seen in first-hand stress exposure. We conclude that stress resonance may be the more empathy-dependent component of the empathic stress construct, aligning with previous work on the involvement of oxytocin and testosterone in empathy. To draw further conclusions about the role of oxytocin and testosterone in empathic stress response, future studies including a control group and hormone stimulation are needed.</p>","PeriodicalId":51173,"journal":{"name":"Stress-The International Journal on the Biology of Stress","volume":"30 1","pages":"2720481"},"PeriodicalIF":3.7,"publicationDate":"2027-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149149686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Trait-like proteomic signatures of stress resilience: correlates of freeze-like response resistance. 应激恢复力的性状样蛋白质组学特征:冻结样反应抗性的相关因素。
IF 3.7 4区 心理学
Stress-The International Journal on the Biology of Stress Pub Date : 2027-12-31 Epub Date: 2026-10-17 DOI: 10.1080/10253890.2026.2733738
Jan Kučera, Markéta Makarová, Michal Vít, Jan Novák, Filip Zlámal, Lucie Ráčková, Jana Fialová Kučerová, Markéta Grulichová, Tomáš Vojtíšek, Radek Šíp, Alžběta Fiedlerová, Julie Bienertová-Vašků
{"title":"Trait-like proteomic signatures of stress resilience: correlates of freeze-like response resistance.","authors":"Jan Kučera, Markéta Makarová, Michal Vít, Jan Novák, Filip Zlámal, Lucie Ráčková, Jana Fialová Kučerová, Markéta Grulichová, Tomáš Vojtíšek, Radek Šíp, Alžběta Fiedlerová, Julie Bienertová-Vašků","doi":"10.1080/10253890.2026.2733738","DOIUrl":"https://doi.org/10.1080/10253890.2026.2733738","url":null,"abstract":"<p><p>The freeze-like response is a fundamental defensive mechanism that remains poorly understood despite its potential to impair functioning under acute threat. We examined its biological correlates using untargeted serum proteomics in participants exposed to ecologically valid simulated armed attacks, comparing untrained individuals (<i>n</i> = 20) with experienced police rapid response personnel (<i>n</i> = 20). Freeze-like responses, characterized by unresponsiveness to attack, were assessed via expert video analysis of participant performance during the scenarios. Serum samples collected before and after threat exposure were analyzed via LC‒MS/MS, identifying 1,238 protein groups. Experienced personnel demonstrated markedly greater resistance to freeze-like responses. No significant proteomic changes were observed from pre- to post-exposure in either group, suggesting that freeze-resistance may be associated with stable, trait-like signatures rather than acute stress-responsive processes. Weighted gene co-expression network analysis identified a module strongly correlated with freeze-resistance (<i>r</i> = 0.75, <i>p</i> = 4 × 10<sup>-9</sup>) and training status (<i>r</i> = 0.71, <i>p</i> = 6 × 10<sup>-8</sup>), which also correlated with skeletal muscle mass (<i>r</i> = 0.57, <i>p</i> = 8 × 10<sup>-5</sup>). This module was enriched for processes including extracellular matrix organization, muscle development, carbohydrate metabolism, and antioxidant activity. These molecular patterns may reflect the downstream effects of comprehensive training that integrates physical conditioning, operational experience, and psychological preparation. This study provides the first proteomic characterization of freeze-like response resistance under realistic threat conditions, supporting the view that resilience involves stable physiological adaptations rather than solely reactive stress mechanisms.</p>","PeriodicalId":51173,"journal":{"name":"Stress-The International Journal on the Biology of Stress","volume":"30 1","pages":"2733738"},"PeriodicalIF":3.7,"publicationDate":"2027-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149217265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Stress-induced gene expression and corticosterone release in adolescent and adult male and female rats after acute or repeated restraint. 应激诱导的青春期和成年雄性和雌性大鼠急性或反复约束后的基因表达和皮质酮释放。
IF 3.7 4区 心理学
Stress-The International Journal on the Biology of Stress Pub Date : 2026-12-31 Epub Date: 2026-01-12 DOI: 10.1080/10253890.2026.2614119
Francine F Burke, Amanda M Leonetti, Jesse M Lacasse, Fardad Pirri, Cheryl M McCormick
{"title":"Stress-induced gene expression and corticosterone release in adolescent and adult male and female rats after acute or repeated restraint.","authors":"Francine F Burke, Amanda M Leonetti, Jesse M Lacasse, Fardad Pirri, Cheryl M McCormick","doi":"10.1080/10253890.2026.2614119","DOIUrl":"10.1080/10253890.2026.2614119","url":null,"abstract":"<p><p>Adolescence is a sensitive window for the maturation of hypothalamic-pituitary-adrenal (HPA) axis function; however, the timing and mechanisms underlying this transition remain unclear, particularly in females and in response to repeated homotypic stress. We measured corticosterone (CORT) release and glucocorticoid-related gene expression in postpubertal (P45) and adult (P75) male and female rats after acute or repeated restraint. In males, adolescents elicited higher CORT responses than adults did after acute stress, although both ages showed habituation to repeated restraint. In contrast, females exhibited adult-like CORT responses by P45 and no evidence of habituation. At the molecular level, adolescents of both sexes displayed distinct medial prefrontal cortex and ventral hippocampus expression profiles of glucocorticoid receptor (<i>Nr3c1</i>) and co-chaperones (<i>Fkbp4</i>, <i>Fkbp5</i>) relative to adults, though these effects were more pronounced in females, for whom there were also age- and stress-dependent changes in mineralocorticoid receptor (<i>Nr3c2</i>) expression. These findings suggest that while hormonal stress responses mature earlier in females than in males, sex-specific trajectories of molecular regulation continue to develop into late adolescence, potentially shaping long-term vulnerability to stress-related disorders.</p>","PeriodicalId":51173,"journal":{"name":"Stress-The International Journal on the Biology of Stress","volume":"29 1","pages":"2614119"},"PeriodicalIF":3.7,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145959319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Acute stress in female adolescent rats increases anxiety-like but not depression-like behaviors. 雌性青春期大鼠的急性压力会增加焦虑样行为,但不会增加抑郁样行为。
IF 3.7 4区 心理学
Stress-The International Journal on the Biology of Stress Pub Date : 2026-12-31 Epub Date: 2026-05-19 DOI: 10.1080/10253890.2026.2675323
Jinglin Xiong, Ioanna Giannakou, Madison O'Bryan, Christin Hartman, Nancy Rempel-Clower
{"title":"Acute stress in female adolescent rats increases anxiety-like but not depression-like behaviors.","authors":"Jinglin Xiong, Ioanna Giannakou, Madison O'Bryan, Christin Hartman, Nancy Rempel-Clower","doi":"10.1080/10253890.2026.2675323","DOIUrl":"10.1080/10253890.2026.2675323","url":null,"abstract":"<p><p>Adolescence is an important developmental period during which heightened stress reactivity and responsiveness increase susceptibility to psychiatric conditions like anxiety and depression. Studies with rodent models have primarily tested the effects of chronic, rather than acute, stress on the development of anxiety- and depression-like behaviors, and many have not included female subjects. The current study examined whether a single acute stress exposure in female rats can induce anxiety-like and depression-like behaviors, and whether the timing of the stress, early (postnatal day 28) versus mid-adolescence (postnatal day 36), influences these outcomes. We used a PTSD-relevant stress paradigm that paired acute immobilization with fox-urine predator odor. Female Sprague-Dawley rats completed a battery of behavioral assays to characterize anxiety-like (elevated plus maze, open field test) and depression-like behaviors (sucrose preference test, forced swim test) between 12 and 16 days postexposure. Acute stress during adolescence caused an increase in anxiety-like behavior, regardless of whether stress occurred in early or mid-adolescence. No increase in depression-like behaviors was observed. Our findings suggest that a single exposure to a predator odor when paired with immobilization is sufficient to increase anxiety-like but not depression-like behaviors in female adolescent rats.</p>","PeriodicalId":51173,"journal":{"name":"Stress-The International Journal on the Biology of Stress","volume":"29 1","pages":"2675323"},"PeriodicalIF":3.7,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147977051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Interoception, blood pressure, and pain: unraveling their interaction under stressful and resting conditions. 内感受、血压和疼痛:在压力和休息条件下揭示它们的相互作用。
IF 3.7 4区 心理学
Stress-The International Journal on the Biology of Stress Pub Date : 2026-12-31 Epub Date: 2026-05-04 DOI: 10.1080/10253890.2026.2666045
A Salaris, S Ravenda, H Al-Naqshbandi, L Provenzano, M C Gerra, E Mattei, G Calcagnini, C Ottaviani, L Carnevali, G Porciello
{"title":"Interoception, blood pressure, and pain: unraveling their interaction under stressful and resting conditions.","authors":"A Salaris, S Ravenda, H Al-Naqshbandi, L Provenzano, M C Gerra, E Mattei, G Calcagnini, C Ottaviani, L Carnevali, G Porciello","doi":"10.1080/10253890.2026.2666045","DOIUrl":"10.1080/10253890.2026.2666045","url":null,"abstract":"<p><p>Elevated blood pressure is commonly linked to diminished pain perception, a phenomenon known as <i>blood pressure-related hypoalgesia</i>. Interoception, the ability to perceive and interpret internal bodily signals, has been previously linked to both blood pressure and pain perception, although findings in the literature remain mixed. We investigated the relationship between blood pressure, pain perception, and interoception under both non-stressful (Pilot Study) and stressful (Main Study) conditions. In the Pilot Study, resting measures of blood pressure, pain thresholds and interoception were assessed in 26 healthy participants. Regression analysis revealed that higher systolic blood pressure was associated with increased pain thresholds, in line with previous findings. In the Main Study, the same variables were assessed in 46 healthy participants at rest and when a stress condition was induced by a validated virtual reality stress paradigm (i.e. the IMVEST). The effectiveness of the stress induction was confirmed through physiological measures (heart rate, heart rate variability, cortisol) and psychological assessments (perceived stress). No significant changes in blood pressure or pain threshold were observed following stress exposure. However, moderation analyses revealed that systolic blood pressure moderated the relationship between interoceptive beliefs (measured via the MAIA questionnaire) and pain perception: a positive association between the tendency to notice internal bodily sensations and pain threshold emerged only in individuals with high systolic blood pressure. This relationship was not observed in individuals with average or low systolic blood pressure. Taken together, these findings suggest that individual differences in cardiovascular physiology and interoceptive processes may shape pain perception.</p>","PeriodicalId":51173,"journal":{"name":"Stress-The International Journal on the Biology of Stress","volume":"29 1","pages":"2666045"},"PeriodicalIF":3.7,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147845712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Valproic acid effects on stress-induced depression-like behavior in rodent models: a systematic review and meta-analysis. 丙戊酸对啮齿动物应激诱导的抑郁样行为的影响:系统回顾和荟萃分析。
IF 3.7 4区 心理学
Stress-The International Journal on the Biology of Stress Pub Date : 2026-12-31 Epub Date: 2026-03-13 DOI: 10.1080/10253890.2026.2641561
Mina Goudarzi, Leila Mohammadi, Masoomeh Sharifi, Michael R Hamblin, Fatemeh Ramezani
{"title":"Valproic acid effects on stress-induced depression-like behavior in rodent models: a systematic review and meta-analysis.","authors":"Mina Goudarzi, Leila Mohammadi, Masoomeh Sharifi, Michael R Hamblin, Fatemeh Ramezani","doi":"10.1080/10253890.2026.2641561","DOIUrl":"10.1080/10253890.2026.2641561","url":null,"abstract":"<p><p>Depression is one of the most common health concerns all around the globe. Valproic acid (VPA) is an anticonvulsant agent, with neuroprotective, anti-apoptotic, anti-inflammatory, and antidepressant effects in animal models. We carried out a systematic review of articles that reported the effect of VPA on stress-related depression in animal models. A search of databases was conducted with keywords related to valproic acid (VPA) and stress-induced depression. Data from the Forced Swimming Test (FST), Open Field Test (OFT), Novel Object Recognition (NOR), and Sucrose Preference Test (SPT) were extracted. Meta-analysis was conducted using Stata 14, and standardized mean differences (SMD) were calculated. Quality control and subgroup analysis were carried out. Meta-analysis of FST results obtained from 16 separate experiments showed that VPA had a strong effect in reducing the percentage immobility, signifying lower stress compared to the untreated group (SMD = -0.93; 95% CI = -1.66 to -0.21; <i>p</i> = 0.012). When administered via injection for four consecutive weeks, VPA at a dosage of 300 mg/kg/day significantly decreased depressive symptoms. Results from the vertical OFT in seven studies and the horizontal OFT in six studies indicated that VPA increased movement scores. SPT results in nine separate experiments showed that VPA significantly increased the animals' desire to drink sucrose water. Analysis of the NOR test demonstrated that VPA had no significant effects on the ability of animals to identify a new object. Our findings suggest that VPA can exert antidepressant-like effects in rat models of stress-induced depression, but heterogeneity and potential publication bias suggests caution is required.</p>","PeriodicalId":51173,"journal":{"name":"Stress-The International Journal on the Biology of Stress","volume":"29 1","pages":"2641561"},"PeriodicalIF":3.7,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147460827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Safety and efficacy of ashwagen (a standardized withania somnifera extract) in stress and anxiety with hypertension and associated cardiometabolic risk factors: a randomized, placebo-controlled trial. ashwagen(一种标准化的withania somnifera提取物)在高血压和相关心脏代谢危险因素的压力和焦虑中的安全性和有效性:一项随机、安慰剂对照试验。
IF 3.7 4区 心理学
Stress-The International Journal on the Biology of Stress Pub Date : 2026-12-31 Epub Date: 2026-05-09 DOI: 10.1080/10253890.2026.2669544
Amrit Pattojoshi, Sudeep Kumar Patra, S A Idrees, Saiprasanna Behera, Snigdha Suman Dalua, Poorva Tiwari, Ramachandran Valavan
{"title":"Safety and efficacy of ashwagen (a standardized withania somnifera extract) in stress and anxiety with hypertension and associated cardiometabolic risk factors: a randomized, placebo-controlled trial.","authors":"Amrit Pattojoshi, Sudeep Kumar Patra, S A Idrees, Saiprasanna Behera, Snigdha Suman Dalua, Poorva Tiwari, Ramachandran Valavan","doi":"10.1080/10253890.2026.2669544","DOIUrl":"10.1080/10253890.2026.2669544","url":null,"abstract":"<p><p>Stress and anxiety are prevalent mental health conditions that often coexist with cardiovascular comorbidities, resulting in a complex interplay between psychological and physiological processes, partly mediated through activation of the hypothalamic-pituitary-adrenal (HPA) axis. Ashwagen®, a standardized extract of <i>Withania somnifera</i> (Ashwagandha), has demonstrated adaptogenic and anxiolytic properties in preclinical and clinical studies. This study aimed to evaluate the safety and efficacy of Ashwagen® in managing stress and anxiety in patients with pre-existing hypertension and associated cardiometabolic risk factors. A randomized, double-blind, placebo-controlled Phase III clinical trial was conducted over 60 days in 60 patients diagnosed with stress, anxiety, and pre-existing hypertension with cardiometabolic risk profiles. Participants received either Ashwagen® (300 mg capsule) or placebo twice daily. Efficacy assessments included validated psychological scales-Hamilton Anxiety Rating Scale (HAM-A), Generalized Anxiety Disorder-7 (GAD-7), Perceived Stress Scale (PSS), Clinical Global Impression-Improvement (CGI-I), Epworth Sleepiness Scale (ESS), and Fatigue Severity Scale (FSS)-along with serum cortisol, triglycerides, LDL, and blood pressure measurements. Ashwagen® significantly reduced anxiety and stress markers compared with placebo. HAM-A, GAD-7, and PSS scores decreased by 26.94%, 50.77%, and 30.47%, respectively, in the Ashwagen® group. Cortisol levels declined by 28.99% and triglycerides by 13.00%, with favorable trends in LDL and blood pressure. No serious adverse events were reported. Ashwagen® was found to be a safe and effective adjunctive integrative intervention for stress and anxiety management in patients with pre-existing hypertension.</p>","PeriodicalId":51173,"journal":{"name":"Stress-The International Journal on the Biology of Stress","volume":"29 1","pages":"2669544"},"PeriodicalIF":3.7,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147864713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Analysis of the electrogastrokinetic changes in a hyperthermia model of rat. 热疗模型大鼠胃电动力学变化分析。
IF 3.7 4区 心理学
Stress-The International Journal on the Biology of Stress Pub Date : 2026-12-31 Epub Date: 2026-09-12 DOI: 10.1080/10253890.2026.2731032
Sugandha Jaiswal, Vinod Kumar Nigam, Rakesh Kumar Sinha
{"title":"Analysis of the electrogastrokinetic changes in a hyperthermia model of rat.","authors":"Sugandha Jaiswal, Vinod Kumar Nigam, Rakesh Kumar Sinha","doi":"10.1080/10253890.2026.2731032","DOIUrl":"https://doi.org/10.1080/10253890.2026.2731032","url":null,"abstract":"<p><p>Heat stress is a condition that develops when the body absorbs more heat than it can dissipate, leading to hyperthermia and problems such as gastrointestinal dysfunction. Past research suggests that gut dysfunction is highly temperature sensitive, and hyperthermia that alters the gut myoelectric activity should be studied properly through electrogastrography. Ten rats, 5 as controls and 5 as hyperthermic, were used in the experiment. For control conditions, a real-time electrogastrogram (EGG) recording was performed at room temperature, and for the induction of hyperthermia, a 42 ± 1 °C temperature was maintained in a closed incubator for 60 min. The rectal temperature was also taken before and after the exposure. The FFT of a full-length recording and five segments, each of 15 min, were analyzed; the wave shift and total time of occurrence of each wave were closely observed. As per the experiment, more spike pattern waves were observed in the hyperthermic rat model (<i>p</i> < 0.01) compared to the control rat, as the heat stress triggers changes in autonomic nervous activity, particularly through the parasympathetic and sympathetic pathways. This imbalance could lead to increased or irregular gastric electrical activity, converting slow waves to spikes. More spike patterns in EGG were observed due to exposure to hyperthermic conditions, which may have occurred due to gut inflammation, altered gastric motility, as well as ion channel dysregulation.</p>","PeriodicalId":51173,"journal":{"name":"Stress-The International Journal on the Biology of Stress","volume":"29 1","pages":"2731032"},"PeriodicalIF":3.7,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148957193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lower and earlier diurnal cortisol signatures of psychological trauma versus comparable physiological stress: one day post-exposure. 较低和较早的每日皮质醇特征的心理创伤与可比的生理应激:暴露后一天。
IF 3.7 4区 心理学
Stress-The International Journal on the Biology of Stress Pub Date : 2026-12-31 Epub Date: 2026-10-29 DOI: 10.1080/10253890.2026.2752711
Jiahao Huang, Yuting Liu, Yujia Wang, Xiao Luo, Feifei Li, Luping Zhang, Lu Wan, Yibo Wang, Xinli Tang, Longqiong Wang, Juan Yang
{"title":"Lower and earlier diurnal cortisol signatures of psychological trauma versus comparable physiological stress: one day post-exposure.","authors":"Jiahao Huang, Yuting Liu, Yujia Wang, Xiao Luo, Feifei Li, Luping Zhang, Lu Wan, Yibo Wang, Xinli Tang, Longqiong Wang, Juan Yang","doi":"10.1080/10253890.2026.2752711","DOIUrl":"https://doi.org/10.1080/10253890.2026.2752711","url":null,"abstract":"<p><p>Traumatic events engage stress physiology, with the hypothalamic-pituitary-adrenal axis and cortisol central to adaptation. In naturalistic trauma, physical injury and psychological distress often co-occur, complicating interpretation of acute cortisol changes. Stillbirth offers a natural contrast: it is physiologically similar to live birth but constitutes traumatic bereavement. This study tested whether psychological trauma elicited by stillbirth is associated with acute alterations in diurnal cortisol rhythm versus comparable physiological delivery stress. Fifty-seven postpartum women were included (stillbirth, 24; live birth, 33). Saliva samples were collected at seven fixed time points across the day following childbirth. Cosinor curve fitting yielded the midline estimating statistic of rhythm, amplitude, and acrophase. Traditional indices included area under the curve with respect to ground, area under the curve with respect to increase, and the cortisol awakening response. Group differences were tested using analyzes of variance. Both groups showed a coherent diurnal pattern. Compared with live birth, stillbirth was associated with a lower area under the curve with respect to ground, a lower area under the curve with respect to increase, and a lower midline estimating statistic of rhythm. Stillbirth was also exhibited associated with an earlier acrophase. Compared with comparable physiological delivery stress, stillbirth is linked to reduced total cortisol secretion, lower mean levels, and an advanced circadian phase in the acute postpartum period, suggesting that the psychological trauma of stillbirth may involve alterations in hypothalamic-pituitary-adrenal axis regulatory patterns and providing preliminary evidence for future work on early biological markers and supportive interventions.</p>","PeriodicalId":51173,"journal":{"name":"Stress-The International Journal on the Biology of Stress","volume":"29 1","pages":"2752711"},"PeriodicalIF":3.7,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149301903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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