EcotoxicologyPub Date : 2024-12-01Epub Date: 2024-10-02DOI: 10.1007/s10646-024-02813-4
Eram Rashid, Syed Makhdoom Hussain, Shafaqat Ali, Pallab K Sarker, Mohammad Abul Farah
{"title":"Investigating the toxicity of polylactic acid microplastics on the health and physiology of freshwater fish, Cirrhinus mrigala.","authors":"Eram Rashid, Syed Makhdoom Hussain, Shafaqat Ali, Pallab K Sarker, Mohammad Abul Farah","doi":"10.1007/s10646-024-02813-4","DOIUrl":"10.1007/s10646-024-02813-4","url":null,"abstract":"<p><p>The widespread presence of microplastics (MPs) in aquatic ecosystems has raised growing concerns among ecotoxicologists regarding their potential toxicity. This study explored the impacts of polylactic acid (PLA) MPs on the physiology and health of freshwater fish, Cirrhinus mrigala, by dietary exposure for 90 days. The experiment consisted of six groups: five treatment groups (0.5%, 1%, 1.5%, 2%, and 2.5% PLA-MP) and a control group (0% PLA-MP). Each group was comprised of fifteen fish, and the experiment was replicated three times. The exposure severity of PLA-MPs varied from low to high, with treatment levels ranging from 0.5% to 2.5% PLA-MPs, relative to the control group. This exposure significantly affected their growth performance. Additionally, the apparent digestibility of the SFM-based diet decreased with increasing PLA-MPs concentration. Exposure to PLA-MPs induced considerable changes in body composition, characterized by increased moisture and crude fat content and decreased ash content and crude protein. The blood profile, including MCHC, RBCs, Hb, PLT and PCV exhibited significant declines in the high treatment group (2.5% PLA-MPs), while MCH, WBCs and MCV showed notable increases. Furthermore, histopathological examination of the intestine revealed an increase in abnormalities in the intestine at 2.5% PLA-MPs level. The high treatment group (2.5% PLA-MPs) showed the lowest mineral content in the fish muscles. In summary, dietary exposure to PLA-MPs led to alterations in overall body performance across the treatment groups, ranging from low to high severity levels.</p>","PeriodicalId":11497,"journal":{"name":"Ecotoxicology","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142361328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Toxicodynamics of cadmium in the green mussel Perna viridis (Linnaeus, 1758) using bioenergetic and physiological biomarkers.","authors":"Kariyil Veettil Neethu, Neethu Xavier, Punnakkal Hari Praved, Naduvath Deepak Sankar, Punnathi Anilkumar Athira, Sivasankaran Bijoy Nandan, Kandussery Joseph Joseph, Shambanagouda Rudragouda Marigoudar, Krishna Venkatarama Sharma","doi":"10.1007/s10646-024-02814-3","DOIUrl":"10.1007/s10646-024-02814-3","url":null,"abstract":"<p><p>This study evaluated the toxicity of cadmium (Cd) on the green mussel Perna viridis, aiming to identify toxicological endpoints and investigate its responses across physiological, bioenergetic, and biochemical parameters. The 96-hour LC<sub>50</sub> value for Cd in P. viridis was 3.03 ± 0.12 mg L<sup>-1</sup>, with a 95% confidence interval of 2.35-3.91 mg L<sup>-1</sup>. Chronic toxicity tests revealed a No Observable Effect Concentration (NOEC), Lowest Observable Effect Concentration (LOEC), and chronic toxicity values of 0.20, 0.37, and 0.29 mg L<sup>-1</sup>, respectively. Cadmium accumulation in treated mussels increased 46- to 215-fold compared to the control group. Superoxide dismutase, catalase, glutathione S-transferase, and glutathione peroxidase levels in exposed mussels exhibited a significant increase compared to the control group. The redox index ratio, acetylcholinesterase activity, and lysosomal membrane stability decreased with increasing exposure concentrations. Levels of reduced and oxidized glutathione, glutathione reductase, lipid peroxidation, and metallothionein-like proteins increased in exposed mussels. Clearance rate, respiration rate, and excretion rate decreased in a dose-dependent manner. Protein, carbohydrate, and lipid levels decreased with increasing exposure concentration (p < 0.001). Mitochondrial electron transport system activity increased, while cellular energy allocation (p < 0.001) and scope for growth decreased in a dose-dependent manner (p < 0.01). The significant increase in antioxidants suggests heightened oxidative stress in mussels under Cd exposure. The physiological activities of the mussels were severely affected, ultimately leading to a reduced scope for growth. The toxicological data generated in this study contribute to the development of seawater quality criteria for the metal Cd.</p>","PeriodicalId":11497,"journal":{"name":"Ecotoxicology","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142388928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Waste managementPub Date : 2024-12-01Epub Date: 2024-09-02DOI: 10.1016/j.wasman.2024.07.034
Alena Maria Spies, Nils Kroell, Annika Ludes, Bastian Küppers, Karoline Raulf, Kathrin Greiff
{"title":"Assessing the resource potential of paper and board in lightweight packaging waste sorting plants through manual analysis and sensor-based material flow monitoring.","authors":"Alena Maria Spies, Nils Kroell, Annika Ludes, Bastian Küppers, Karoline Raulf, Kathrin Greiff","doi":"10.1016/j.wasman.2024.07.034","DOIUrl":"10.1016/j.wasman.2024.07.034","url":null,"abstract":"<p><p>The recycling of paper and board (PB) yields economic and environmental advantages compared to primary paper production. However, PB from lightweight packaging (LWP) waste is currently not comprehensively reintegrated into the paper value stream. To develop an adapted recycling process for PB from LWP, PB quantities, qualities, and fluctuations ranges in LWP are required. Currently, no sufficient database is available. Therefore, we developed a methodical approach and conducted a case study to access the PB potential in LWP sorting plants using manual analysis and sensor-based material flow monitoring. Differences resulting from seasonal variations, materials from different settlement structures, and fluctuation ranges in LWP composition over two weeks have been investigated. PB contents in the input of 6.5 wt% (ww) and 5.9 wt% (ww) were determined for winter and summer sampling campaigns, respectively. The PB product stream amounted to 5.7 wt% (ww, winter) and 4.8 wt% (ww, summer). Around 45 wt% (ww) of PB from the PB product stream was classified as misplaced by the consumer and should have been discarded in separate paper collections. Based on the determined PB quantities and qualities, a potential of usable and in the PB product stream available PB in LWP was determined. The technically available and usable PB potential in German LWP waste amounts to 89,000 to 100,000tons per year (average PB yield of around 65 wt% (ww)). The methodical approach can be adapted for sorting plant balances. The results can contribute to developing an adapted recycling process for PB from LWP.</p>","PeriodicalId":23969,"journal":{"name":"Waste management","volume":null,"pages":null},"PeriodicalIF":7.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142112755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
EcotoxicologyPub Date : 2024-12-01Epub Date: 2024-10-06DOI: 10.1007/s10646-024-02804-5
Katheryn Klajman, Peter Beckett, Graeme Spiers, Kabwe Nkongolo
{"title":"Effects of aerial liming on soil chemical and biological properties in metal contaminated and inaccessible lands in Ontario (Canada).","authors":"Katheryn Klajman, Peter Beckett, Graeme Spiers, Kabwe Nkongolo","doi":"10.1007/s10646-024-02804-5","DOIUrl":"10.1007/s10646-024-02804-5","url":null,"abstract":"<p><p>The manual addition of lime to soil, in addition to tree planting and fertilization have been the dominant strategy described in restoration protocols for ecosystems damaged by acid rain and metal contamination. Investigations on aerial-limed soils in inaccessible lands are limited. The objective of this study was to assess the effects of aerial liming on soil pH, organic matter, microbial biomass, and enzymatic activities, and aboveground plant population quality in metal-contaminated lands in northern Ontario, Canada. Soil samples were collected from three sites around the City of Greater Sudbury with each pair being composed of a reclaimed (areal-limed) site and an adjacent undisturbed (unlimed) area. Soil physico-chemistry, microbial biomass (assessed by Phospholipid fatty acid analysis) and enzymatic activities were analyzed. Soil pH was higher in limed sites compared to unlimed at recently restored sites (Baby Lake and Wahnapitae) but not at the oldest reclaimed site (HWY 80 N). Organic matter was higher in limed areas compared to the unlimed reference site only at most recently reclaimed site at Baby Lake. Aboveground plant population health was visibly improved in limed sites compared to unlimed areas. Metal concentrations of iron (Fe) and arsenic (As), total microbial biomasses, gram-negative bacterial, fungal, and eukaryotic biomasses were all significantly increased in the limed soils compared to the unlimed samples. The same trend was observed for the activities of three of the enzymes tested, β-N-acetylglucosaminidase (BG), aryl sulfatase (AS), and glycine aminopeptidase (GAP). Interestingly, strong positive correlations between the levels of soil organic matter, microbial biomasses, and NAGase and ALP activities were observed. Although expensive, aerial liming is effective in restoring inaccessible sites impacted by smelting operations where other methods cannot easily be used.</p>","PeriodicalId":11497,"journal":{"name":"Ecotoxicology","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142379224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Phytotoxicity of single and mixed rare earth element (La, Nd and Sm) exposures on Lactuca sativa seed germination and growth.","authors":"Silvia Gonçalves Egler, Tamine Martins Roldão, Gabriel Oliveira Santos, Gisele Petronilho Heidelmann, Inês Gomes Fraga, Fabio Veríssimo Correia, Enrico Mendes Saggioro","doi":"10.1007/s10646-024-02812-5","DOIUrl":"10.1007/s10646-024-02812-5","url":null,"abstract":"<p><p>The mode of action, bioaccumulation potential and toxicity of Rare Earth Elements (REE), with several applications in the technology, medical and agricultural fields, are still understudied. The nitrates acute effects on single exposures, binary and ternary mixtures of lanthanum (La), neodymium (Nd) and samarium (Sm) on Lactuca sativa lettuce seed germination and wet biomass in an artificial soil (AS) and an Ultisol were assessed. Germination (EC<sub>50</sub>), wet biomass (IC<sub>50</sub>) and germination inhibition (% GI) were evaluated. EC<sub>50</sub> values show La was the most toxic in Ultisol, Sm in AS, and Nd appears with intermediate values on both substrates. The IC<sub>50</sub>, both single and mixed, decreased from 3- to 181-fold with increasing test concentrations in relation to the control in AS, while increases in Ultisol were observed, followed by decreases at higher doses which may be associated with the low-dose stimulation effect (hormesis). Our findings may be used to subsidize REE risk assessment studies and reinforce the hormesis effect to prevent the use of high application of REE fertilizers, avoiding the accumulation of REE in agricultural soils.</p>","PeriodicalId":11497,"journal":{"name":"Ecotoxicology","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142388926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
EcotoxicologyPub Date : 2024-12-01Epub Date: 2024-10-09DOI: 10.1007/s10646-024-02811-6
Djamila Hafsi, Ibtissem Sbartai, Hana Sbartai
{"title":"Stress biomarker response in Aporrectodea caliginosa earthworms exposed to single and combined pesticide treatments (Prosaro and Decis).","authors":"Djamila Hafsi, Ibtissem Sbartai, Hana Sbartai","doi":"10.1007/s10646-024-02811-6","DOIUrl":"10.1007/s10646-024-02811-6","url":null,"abstract":"<p><p>This study aims to assess the impact of two pesticides commonly used in Algeria (Prosaro XRT and Decis 25 EC), as well as their combinations at recommended doses, on a non-target species bioindicator of soil pollution, the earthworm Aporrectodea caliginosa, using physiological (mortality and growth) and biochemical parameters (proteins, glutathione, catalase activity and glutathione S-transferase, acetylcholine esterase, lipoxygenase). The recommended dose and its double were tested individually and in combination for this. It should be noted that the protocol used and the initial concentrations selected are the same as those used in the field. After 7 and 14 days (7D/14D) of exposure, all dosages were administered. Our findings show that the pesticides tested had no effect on earthworm survival. However, a significant decrease in their growth rates depending on the different concentrations was observed for the different treatments over the entire exposure period of 7 or 14 D. The greatest reductions (31.62%, 35.04%) are reported after 14D for the high concentrations of Decis alone (D2) as well as for the combined treatment Prosaro/Decis (P2/D2). At the same time, an increase in total protein contents (more than 50% after 14D) as well as a decrease in acetylcholine esterase activity were reported for all treatments. We were also able to identify the induction of oxidative stress after xenobiotic exposure, which is more pronounced at the end of the treatment (14D), resulting in the stimulation of the antioxidant system (gluthione, glutathione S-transférase, catalase) as well as the induction of lipoxygenase, which is responsible for the oxidation of polyunsaturated fatty acids as well as the generation of reactive oxygen species (ROS) involved in the inflammatory phenomenon. Finally, it turns out that the species Aporrectodea caliginosa is sensitive to the different concentrations applied, even those used in the open field, and that Decis (deltamethrin) seems to be more toxic than Prosaro and that the combinaison P2/D2 is as toxic as Decis alone (D2).</p>","PeriodicalId":11497,"journal":{"name":"Ecotoxicology","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142388927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Historical evolution of olive oil production processes focusing on the role of water, the contribution of energy sources, and the by-product management: The case-study of Crete, Greece.","authors":"Iosif E Kapellakis, Konstantinos P Tsagarakis","doi":"10.1016/j.scitotenv.2024.175861","DOIUrl":"10.1016/j.scitotenv.2024.175861","url":null,"abstract":"<p><p>There are numerous studies dealing with olive oil management from ancient civilizations to the mid last century, but they are limited on the historical value of information. At the same time, much knowledge is widely available and accessible on the contemporaneous production of olive oil, the necessary inputs (water and energy) and outputs (by-products) of the production process. The present study aims to shed light on olive oil extraction management from antiquity to present and to bridge the gap between archaeological and modern agricultural, engineering, and environmental disciplines. For the purposes of this study, Crete, Greece, a well-known and traditional olive oil producing region is investigated. This study is dedicated to unveil practices concerning: (a) the processing of the olives, (b) the various energy aspects per era, (c) the role of water and energy at each stage of the extraction process, and (d) management of by-products per era. The main findings support that: (a) the evolution of the extraction processes was relatively slow and remained almost the same from Minoan times until the middle of the 20th century, (b) the importance of water has been demonstrated from the beginning in the efficient extraction of the maximum amount of olive oil, (c) wastewater was first reported during the Hellenistic-Roman period due to the increased quantities produced, (d) by-product management was only considered in the previous century for environmental purposes, (e) olive oil production has been a human-based process for centuries and was greatly increased by the introduction of animals, and (f) olive oil production was further increased with the utilization of mechanical and electrical energy. It can be therefore clearly concluded that past practices have both similarities and differences with the present ones, which in turn have been optimized in terms of energy sources, water uses, olive mill equipment, and environmental considerations, to result in maximum olive oil production with minimum environmental impacts. Based on this work, important lessons can be drawn that show the historical evolution of extraction and management practices.</p>","PeriodicalId":422,"journal":{"name":"Science of the Total Environment","volume":null,"pages":null},"PeriodicalIF":8.2,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142102989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Camille Rousset, Henri Bréfort, Rafael Frederico Fonseca, Guillaume Guyerdet, Florian Bizouard, Mustapha Arkoun, Catherine Hénault
{"title":"Surprising minimisation of CO<sub>2</sub> emissions from a sandy loam soil over a rye growing period achieved by liming (CaCO<sub>3</sub>).","authors":"Camille Rousset, Henri Bréfort, Rafael Frederico Fonseca, Guillaume Guyerdet, Florian Bizouard, Mustapha Arkoun, Catherine Hénault","doi":"10.1016/j.scitotenv.2024.175973","DOIUrl":"10.1016/j.scitotenv.2024.175973","url":null,"abstract":"<p><p>Agricultural liming improves acidic soils productivity and is considered a lever for mitigating nitrous oxide (N<sub>2</sub>O) emissions from soils. However, the benefit of liming in reducing soil greenhouse gas (GHG) emissions depends on the evolution of carbon from the calcium carbonate (CaCO<sub>3</sub>), and on the evolution of soil organic carbon (SOC) after CaCO<sub>3</sub> application. The literature, based on limited field data, presents contrasting effects of liming on inorganic- and SOC-derived CO<sub>2</sub> emissions, raising concerns that the reduction in N<sub>2</sub>O emissions could be offset by increased CO<sub>2</sub> emissions. Therefore, this study aimed to monitor N<sub>2</sub>O and CO<sub>2</sub> emissions following the application of lime materials to an acidic soil. In situ, we monitored the effect of two liming products (SC = synthetic CaCO<sub>3</sub> and MC = marine CaCO<sub>3</sub>) on soil CO<sub>2</sub> emissions and compared this with control plots, during the growing season of a winter rye, using the static chamber method. Soil pH, N<sub>2</sub>O emissions, mineral nitrogen concentrations, soil moisture and temperature were measured during the experiment, as were plant biomass and SOC (stock and composition) on the day of harvest. Lime addition increased soil pH from 5.7 to around 7.0, kernel yield from 320 to >400 g m<sup>-2</sup> and resulted in a significant reduction in soil CO<sub>2</sub> emissions by approximately 40 % for both liming materials while it slightly increased N<sub>2</sub>O emissions, that had nevertheless remained very low during the experiment. SOC at harvest was not significantly affected, while an increase in dissolved organic and inorganic carbon in the soil was observed. Further investigations is needed to clarify the mechanisms explaining these observations and to define conditions where liming application could act as a potential lever for carbon storage. Our results suggest that the IPCC principles, predicting increased CO<sub>2</sub> emissions from lime-derived C, may need to be re-examined in the future.</p>","PeriodicalId":422,"journal":{"name":"Science of the Total Environment","volume":null,"pages":null},"PeriodicalIF":8.2,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142152925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"An unconventional approach to evaluating the environmental role of a productive system: An environmental assessment of beef farms in North-West Italy.","authors":"Davide Biagini, Marco Betta","doi":"10.1016/j.scitotenv.2024.176100","DOIUrl":"10.1016/j.scitotenv.2024.176100","url":null,"abstract":"<p><p>The environmental impact of livestock is often evaluated separately from the other agricultural activities involved in an integrated system, such as that of the rearing of Piemontese cattle in the area of origin of the breed. The most frequently used assessment methods (e.g. Footprint approaches or a Life Cycle Assessment) are in fact often used, through a product-based approach, to analyse a single productive process, but such methods do not consider the production of agro-ecological services, and they neglect the interactions that characterise complex systems. Moreover, such methods often only consider the negative aspects of the environmental impact and misrepresent less intensive agriculture practices. However the current gaps in knowledge about the carbon sequestration of agricultural ecosystems, which are complex and integrated systems, require further investigation and other types of analysis tools. A carbon (C) balance of 1223 Piemontese breed beef farms, located in North-West Italy, has been calculated to evaluate whether such a method could be applied to overcome the aforementioned limitations, to evaluate whether it could be used to describe a complex and integrated system, to highlight the relationships that exist between rearing and agricultural activities and to characterise their environmental roles. Conducting a mass balance involves considering the input and output material flows and their accumulation within a system. Thus, the data necessary to quantify the C input, output and internal fluxes of a system at the farm gate, pertaining to the vegetable and animal production processes (productive factors, crop yields, animal performances, productions and sales, reuses), were collected from official documentation, and were then completed and verified through site visits. The mass balance of the system was transformed into C fluxes using stoichiometric coefficients. The fluxes evaluated for the balance were then used to estimate the changes in the C stocks to highlight not only the C emissions or losses from the system, but also their contributions towards reducing environmental hazards. A sensitivity analysis was carried out to evaluate the uncertainty and the robustness of the obtained results. The net C exchange from plants was the flux that contributed the most, amounting to 94.3 % of the inputs, and this was followed by soil losses and animal gases released through respiration and enteric fermentation, which amounted to 42.8 and 36.2 % of the outputs, respectively. The C stored and released by the considered system was calculated considering the C fluxes. Plant, animal and soil storage sites were included in the system, whereas the air site was left out. A constant C content was assumed for the soil. The productive activities of the selected group of beef farms in the Consortium were calculated to remove 96.1 10<sup>3</sup> t of C from the atmosphere (air site) over a period of one year, and that this amount of C was trans","PeriodicalId":422,"journal":{"name":"Science of the Total Environment","volume":null,"pages":null},"PeriodicalIF":8.2,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142278363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zuhai Chen, Wanting Wei, Yunhua Hu, Qiang Niu, Yizhong Yan
{"title":"Associations between co-exposure to per- and polyfluoroalkyl substances and metabolic diseases: The mediating roles of inflammation and oxidative stress.","authors":"Zuhai Chen, Wanting Wei, Yunhua Hu, Qiang Niu, Yizhong Yan","doi":"10.1016/j.scitotenv.2024.176187","DOIUrl":"10.1016/j.scitotenv.2024.176187","url":null,"abstract":"<p><strong>Background: </strong>Per- and polyfluoroalkyl substances (PFAS) pose potential risks to human health. In real-world settings, humans are exposed to various PFAS through numerous pathways.</p><p><strong>Objectives: </strong>This study evaluated the associations between co-exposure to PFAS and obesity and its comorbidities, along with the mediating roles of inflammation and oxidative stress.</p><p><strong>Methods: </strong>We analyzed 11,090 participants from National Health and Nutrition Examination Survey (NHANES), 2003-2018. Linear regression, logistic regression, and generalized additive models were used to assess the individual effects of PFAS exposure on obesity and its comorbidities. The environmental risk score (ERS) was calculated using the adaptive elastic-net model to assess the co-exposure effects. Linear and logistic regression models explored the associations between ERS and obesity and its comorbidities. Mediation analyses explored the roles of inflammatory (neutrophils, lymphocytes, and alkaline phosphatase) and oxidative stress (gamma-glutamyl transferase, total bilirubin, and uric acid) markers in the associations between ERS and obesity and its comorbidities.</p><p><strong>Results: </strong>For each unit increase in ERS, the odds of obesity and type 2 diabetes mellitus (T2DM) increased 3.60-fold (95 % CI: 2.03, 6.38) and 1.91-fold (95 % CI: 1.28, 2.86), respectively. For each unit increase in ERS, BMI increased by 2.36 (95 % CI: 1.24, 3.48) kg/m<sup>2</sup>, waist circumference increased by 6.47 (95 % CI: 3.56, 9.37) cm, and waist-to-height ratio increased by 0.04 (95 % CI: 0.02, 0.06). Lymphocytes, alkaline phosphatase, and total bilirubin were significantly associated with both ERS and obesity, with mediation proportions of 4.17 %, 3.62 %, and 7.37 %, respectively. Lymphocytes, alkaline phosphatase, total bilirubin, and uric acid were significantly associated with both ERS and T2DM, with the mediation proportions of 8.90 %, 8.74 %, 29.73 %, and 38.19 %, respectively.</p><p><strong>Conclusions: </strong>Co-exposure to PFAS was associated with obesity and T2DM, and these associations may be mediated by inflammation and oxidative stress. Further mechanistic and prospective studies are required to verify these associations.</p>","PeriodicalId":422,"journal":{"name":"Science of the Total Environment","volume":null,"pages":null},"PeriodicalIF":8.2,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142278366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}