Environmental Pollution最新文献

{"title":"The association between maternal exposure to ten neonicotinoid insecticides and preterm birth in Guangxi, China","authors":"Dongxiang Pan, Lihong Zhou, Changhui Mu, Mengrui Lin, Xiaogang Wang, Qian Liao, Lidi Lei, Shun Liu, Dongping Huang, Xiaoqiang Qiu, Xiaoyun Zeng","doi":"10.1016/j.envpol.2025.126477","DOIUrl":"https://doi.org/10.1016/j.envpol.2025.126477","url":null,"abstract":"Preterm birth (PTB) is a primary cause of mortality among newborns globally. Prenatal exposure to environmental pollutants has been suggested to increase the PTB risk. Studies have shown NEOs may be linked to adverse birth outcomes. However, the impact of maternal NEOs exposure on PTB remains unclear. Therefore, to examine the association between NEOs exposure and PTB risk, we performed a case-control analysis utilizing data from a birth cohort study in Guangxi, China. A total of 157 preterm infants and 471 full-term infants were included. Concentrations of 10 NEOs and their metabolites in maternal serum were quantified using liquid chromatography-tandem mass spectrometry. We employed logistic regression, quantile g-computation, and restricted cubic spline models to evaluate the effects of individual and mixed NEO exposures. Subsequently, XGBoost machine learning, combined with SHAP, was employed to predict the implications of serum NEOs on PTB. Finally, for 1-standard deviation increment in ln-transformed concentrations of imidacloprid and dinotefuran, significant correlations with higher odds of PTB were observed, showing odds ratios of 1.17 (95% CI: 1.02, 1.36) and 1.41 (95% CI: 1.16, 1.72). Similar patterns and higher risks were observed in late preterm birth. In both mixed exposure and machine learning models, DIN and IMI were identified as major predictors of increased PTB risk. Exposure to n-desmethylacetamiprid, sulfoxaflor, thiacloprid, nitenpyram, and thiamethoxam was negatively associated with PTB. Our findings suggested dinotefuran and imidacloprid exposure during pregnancy were risk factors of PTB, particularly among late preterm births. Subsequent research is necessary to illuminate the underlying mechanisms involved.","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"2 1","pages":"126477"},"PeriodicalIF":8.9,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144083270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response of 137Cs dynamics in dam lakes to temperature and weather conditions","authors":"Hideki Tsuji, Tatsuhiro Nishikiori, Shoko Ito, Hirokazu Ozaki, Mirai Watanabe, Masaru Sakai, Yumiko Ishii, Seiji Hayashi","doi":"10.1016/j.envpol.2025.126445","DOIUrl":"https://doi.org/10.1016/j.envpol.2025.126445","url":null,"abstract":"This study examined the influence of dam lakes on ¹³⁷Cs dynamics in downstream river systems based on monthly observations of inflow/discharge water over 10 years at the Matsugabo Dam and Yokokawa Dam, which were affected by the Fukushima Daiichi nuclear power plant accident in 2011. Dissolved ¹³⁷Cs concentrations in the discharge water of both dams showed seasonal fluctuation, but the phase of the fluctuation lagged that of water temperature, and the relationship between the distribution coefficient of ¹³⁷Cs and temperature in the dam discharge water was poorly reproduced by the van’t Hoff equation. These discrepancies indicate that dissolved ¹³⁷Cs concentrations in the dam discharge are not determined predominantly by in situ ion exchange between solid and aqueous phases. In autumn 2019, dissolved ¹³⁷Cs concentrations in the discharge of both dams decreased markedly, and the role of the Yokokawa Dam lake shifted from that of a source to a sink of dissolved ¹³⁷Cs for the following three years. This occurred because Typhoon Hagibis brought intensive rainfall and caused watershed erosion, which resulted in accumulation of large amounts of sediment and changed the ¹³⁷Cs balance between the water and sediment in the dam lake. When dam water storage decreased, notable increase in dissolved ¹³⁷Cs concentration was observed in the discharge water. Multiple partial regression indicated that water level decline is more influential relative to water temperature rise regarding the increase in dissolved ¹³⁷Cs concentrations in lake water, suggesting that water level management could mitigate the elevation of ¹³⁷Cs concentration in discharge water.","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"300 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144067388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of microplastics on tissue-specific gene expression in the tropical house cricket, Gryllodes sigillatus","authors":"Alexandra Cheslock, Jennifer Provencher, Winston Campeau, Heath A. MacMillan","doi":"10.1016/j.envpol.2025.126475","DOIUrl":"https://doi.org/10.1016/j.envpol.2025.126475","url":null,"abstract":"Microplastics are ubiquitous in our environment, resulting in animal exposure and consumption via food, water, and air. Animals that consume microplastics may suffer from physiological effects like immunotoxicity or mitochondrial dysfunction, but how specific tissues may differentially respond to plastic consumption is poorly understood, particularly in terrestrial insects. Here, we measured transcriptomic responses of tissues (midgut, hindgut, fat body and ovaries) to microplastic consumption in a generalist ground-dwelling insect, the tropical house cricket, <em>Gryllodes sigillatus</em>. Using this approach, we provide insights on how microplastics may impact specific organ systems. We generated a <em>de novo</em> transcriptome, a useful resource for further studies on this emerging model insect, that we then used to infer differential gene expression due to microplastic consumption in individual organs. Ingestion of microplastics elicited unique changes in gene expression depending on the tissue of focus, with notable differentially-expressed genes related to survival and stress pathways as well as those related to metabolism, immunity, and cancer.","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"120 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144066737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synergistic effects of air pollution and artificial light at night on diabetes risk: A prospective cohort study","authors":"Desong Wen, Fei Lin, Chaowei Zhang, Ziyu Ge, Xiaohang Li, Zhenzhou Liu, Hanqing Zhao, Weimin Wang, Zhigang Chen, Guoan Zhao","doi":"10.1016/j.envpol.2025.126472","DOIUrl":"https://doi.org/10.1016/j.envpol.2025.126472","url":null,"abstract":"Previous studies have indicated associations between air pollutants, outdoor artificial light at night (ALAN) exposure, and diabetes risk, but their interactive effects remain insufficiently validated. Based on data from two large Chinese cohorts (CHARLS and CFPS) with 28,903 participants followed for 3 years (2013-2018), we employed Cox proportional hazards regression models to evaluate the associations of pollutants and outdoor ALAN with diabetes incidence risk and their interactions, along with stratified analyses. Results demonstrated significant linear relationships between PM₁ and PM_2.5 concentrations and diabetes risk. Each 10 μg/m³ increase in PM₁ and PM_2.5 was associated with hazard ratios (HRs) of 1.065 (95% CI: 1.061-1.069) and 1.036 (95% CI: 1.034-1.038), respectively. Other pollutants (SO₂, NO₂, and CO) and outdoor ALAN exposure showed non-linear associations with diabetes risk, with each standard deviation increase in outdoor ALAN exposure associated with an HR of 1.004 (95% CI: 1.001-1.007). Furthermore, co-exposure to PM₁, PM_2.5, PM₁₀, and SO₂ with outdoor ALAN demonstrated significant additive effects. Stratified analyses revealed significantly higher diabetes risks among individuals aged ≥65 years and unmarried populations. Regional differences showed higher pollutant susceptibility among northern residents, while southern residents demonstrated greater sensitivity to outdoor ALAN exposure. This study revealed for the first time significant synergistic effects between environmental pollutants and outdoor ALAN exposure on diabetes risk, highlighting the importance of environmental and light pollution in diabetes prevention and control, and providing theoretical basis for future policy development.","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"18 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144066738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of non-essential metal mixture with biological aging and the mediating role of inflammation in Chinese older adults","authors":"Yan Zhang ,&nbsp;Yuan Wang ,&nbsp;Xuqiu Cheng ,&nbsp;Ziwei Tian ,&nbsp;Yuantao Zhang ,&nbsp;Wenyuan Liu ,&nbsp;Xianglong Liu ,&nbsp;Bing Hu ,&nbsp;Fangbiao Tao ,&nbsp;Anna Bi ,&nbsp;Jun Wang ,&nbsp;Linsheng Yang","doi":"10.1016/j.envpol.2025.126474","DOIUrl":"10.1016/j.envpol.2025.126474","url":null,"abstract":"<div><h3>Background</h3><div>Individual non-essential metals (NMs) have been linked with biological aging. However, the effects of NM mixture and their mechanisms remain unclear.</div></div><div><h3>Objective</h3><div>To characterize the relationships of individual NMs and their mixture to biological aging, and to explore the mediating roles of inflammatory factors.</div></div><div><h3>Methods</h3><div>This cross-sectional study recruited 3251 individuals aged 60 years or above in China. Urine gallium, arsenic, cadmium, cesium, thallium, and barium were tested using ICP-MS. The Klemera-Doubal method was used to construct the KDMAge, reflecting the estimation of biological age, and ΔKDMAge, defined as the difference between KDMAge and chronological age, reflecting the deviation in aging rate. Four blood cell counts, including neutrophil, lymphocyte, platelet, and monocyte, were used to calculate inflammatory indices: neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, lymphocyte-to-monocyte ratio, and systemic immune-inflammation index. Linear regression, generalized additive model (GAM), weighted quantile sum (WQS), quantile-based computation (QGC), and Bayesian kernel machine regression (BKMR) were employed to assess the associations between the NMs and ΔKDMAge. Mediation analysis was further performed to examine the roles of inflammatory factors.</div></div><div><h3>Results</h3><div>KDMAge strongly correlated with chronological age (<em>r</em> = 0.863). Linear regression showed significant positive associations of Gallium (<em>β</em> = 0.88, 95 % <em>CI</em> = 0.30, 1.46), arsenic (<em>β</em> = 1.11, 95 % <em>CI</em> = 0.54, 1.69), and cesium (<em>β</em> = 0.75, 95 % <em>CI</em> = 0.19, 1.30) with ΔKDMAge. GAMs further exhibited a “J-shaped” relationship for gallium, arsenic with ΔKDMAge, a linear trend for cesium, and a “U-shaped” relationship for barium. The mixture models demonstrated a positive association between the NM mixture and ΔKDMAge, with gallium, arsenic, and cesium identified as the primary contributors. Mediation analyses further suggested that neutrophil-to-lymphocyte ratio and systemic immune-inflammation index partially mediated this association.</div></div><div><h3>Conclusions</h3><div>The NM mixture accelerates biological aging, mainly driven by gallium, arsenic, and cesium, with partial mediation by inflammation. Future longitudinal studies are necessary to verify these findings.</div></div>","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"377 ","pages":"Article 126474"},"PeriodicalIF":7.6,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144066703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between ambient fine particulate matter constituents and mortality and morbidity of cardiovascular and respiratory diseases: A systematic review and meta-analysis","authors":"Jie Yan, Zhaoyang Li, Kai Wang, Cuiyao Xie, Jiaqi Zhu, Shaowei Wu","doi":"10.1016/j.envpol.2025.126476","DOIUrl":"https://doi.org/10.1016/j.envpol.2025.126476","url":null,"abstract":"Existing studies have explored the associations between short-term or long-term exposures to PM_2.5 constituents and mortality and morbidity outcomes related to all-causes, natural causes and the cardiopulmonary system, but the results are still inconclusive. To explore the associations between short-term and long-term exposures to ambient PM_2.5 constituents with mortality and morbidity outcomes of all-cause, natural, cardiovascular and respiratory diseases. We comprehensively searched PubMed, Embase, Web of Science and Scopus electronic databases to identify studies until 28, August 2023. We estimated the pooled relative risk (RR) with 95% confidence interval (CI) using random-effect models. Then we explored potential sources of heterogeneity across different studies by subgroup and meta-regression analysis. A total of 67 articles were included in the meta-analysis. We found that short-term exposures to PM_2.5 carbon-containing constituents (black carbon and organic carbon) and metal iron showed the most consistent associations with the eight health outcomes among different PM_2.5 constituents. Meanwhile, only long-term exposures to nitrate ions and silicon in PM_2.5 showed significant positive associations with cardiovascular and natural mortality outcomes. Additionally, subgroup and meta-regression analyses highlight that geographical region and age group are primary sources of heterogeneity. The current meta-analysis reveals potential key PM_2.5 constituents associated with elevated risk of mortality and morbidity of cardiovascular and respiratory diseases. Thus, greater attention should be directed toward establishing exposure limits for specific PM_2.5 constituents to protect public health and alleviate the associated burden of diseases.","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"16 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144066699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Path analysis of trace elements and physiological and biochemical indices associated to mild cognitive impairment in elderly Chinese","authors":"Peiyi Liu, Haiyan Huang, Qimei Zhou, Ying Zhi, Jiahui Wang, Ying Fu, Erwei Gao, Xiaohu Ren, Xiao Chen, Xinfeng Huang, Jianjun Liu, Xifei Yang","doi":"10.1016/j.envpol.2025.126470","DOIUrl":"https://doi.org/10.1016/j.envpol.2025.126470","url":null,"abstract":"The intricate relationships between cognitive function and a broad spectrum of trace elements and physiological and biochemical indices remain unclear. This study aimed to employ a path analysis model to investigate the effects of multiple trace elements and physiological and biochemical factors on mild cognitive impairment (MCI) among elderly Chinese. A total of 5,768 residents aged 60 years and older were recruited in Shenzhen, China. Cognitive function was evaluated using the Mini-Mental State Examination and the Mini-Cognitive Assessment. Concentrations of 18 trace elements in urine were quantified with adjustments for urinary creatinine levels. Physiological and biochemical indices were acquired at community health centers. Based on the multiple logistic regression analysis, only selenium exhibited significant negative correlations with MCI (<em>p</em>-trend = 0.035). Serum albumin (ALB), triglyceride (TG), bone mineral density (BMD) and mitochondrial DNA copy number (mtDNAcn) exhibited negative correlations with high risk of MCI, whereas serum uric acid (SUA) and fasting blood glucose (FBG) were positively correlated with a higher risk of MCI. In addition, the path analysis model demonstrated that cobalt had direct effect on cognitive function, whereas iron, manganese, selenium, zinc, and copper affected it indirectly. Furthermore, the model identified that mtDNAcn directly affected cognitive function, while the other four physiological and biochemical indicators, including ALB, TG, BMD and SUA, had both direct and interactive indirect effects on it. Trace elements and physiological and biochemical indices exerted both direct and indirect effects on MCI. Specifically, trace elements might indirectly affect cognitive function through physiological and biochemical indices, which interact with each other.","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"6 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144066701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Urinary Pesticide Metabolites and Iodine with Thyroid Volume in School-Aged Children","authors":"Fuhai Zhong, Conghui Xu, Fenfang Deng, Juntao Li, Yuehong Wei, Pengzhe Qin, Rongfei Peng, Lei Tan","doi":"10.1016/j.envpol.2025.126469","DOIUrl":"https://doi.org/10.1016/j.envpol.2025.126469","url":null,"abstract":"Monitoring thyroid volume in children allows for non-invasive, intuitive, and rapid assessment of potential thyroid disorders, facilitating early detection in large-scale screenings without blood draws. In this study, we investigated associations between urinary pesticide metabolites (organophosphate, pyrethroid, and phenoxy carboxylic acid), urinary iodine, and thyroid volume in children aged 8-11 years across Guangzhou districts, China. We compared the spatial distribution of urinary pesticide metabolites among districts and assessed health risks using probabilistic Monte Carlo simulation. We evaluated associations between thyroid volume and multiple factors: urinary iodine, demographic variables, anthropometric measures, environmental factors, and urinary creatinine. The associations between pesticide metabolites and thyroid volume were assessed using multivariable linear regression, trend tests, and restricted cubic splines. The joint effects of multiple pesticide metabolites on thyroid volume were evaluated by the Bayesian kernel machine regression. The role of urinary iodine was explored through mediation and moderation analyses. The result revealed that 0.89% of children had risk levels of parathion exposure. Thyroid volume showed positive correlations with age and body surface area but negative correlation with urinary iodine. Two pyrethroid metabolites, <em>cis</em>-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropane-1-carboxylic acid (<em>cis</em>-DCCA) and <em>trans</em>-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropane-1-carboxylic acid (<em>trans</em>-DCCA), demonstrated negative associations with thyroid volume after covariate adjustment. While thyroid volume decreased with higher pesticide metabolite concentrations, this joint effect was not statistically significant. The associations between thyroid volume and <em>cis</em>-DCCA and <em>trans</em>-DCCA were fully mediated by urinary iodine, but the metabolites' effects on thyroid volume remained consistent across different urinary iodine concentrations. The results indicated that pesticide exposure may influence thyroid volume through an iodine-mediated pathway and highlighted the importance of iodine status in thyroid health assessment.","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"4 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144066698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the association between air pollution and urogenital congenital anomalies: a global ecological analysis","authors":"Kebin Chen, Hanjun Liu, Tingting Wang, Manjun Luo, Xiaorui Ruan, Mengting Sun, Ziye Li, Jianhui Wei, Jiabi Qin","doi":"10.1016/j.envpol.2025.126471","DOIUrl":"https://doi.org/10.1016/j.envpol.2025.126471","url":null,"abstract":"The relationship between air pollution and urogenital congenital anomalies (UCAs) remains poorly understood. This study performed an ecological analysis of air pollution emissions and the burden of UCAs, aiming to offer new global insights for air pollution control. Data were obtained from the Global Burden of Disease Study 2021 and Emission Database for Global Atmospheric Research. Joinpoint regression assessed temporal trends in burden of UCAs, mixed-effects, nonlinear lag and time-varying effect models were used to investigate potential associations between air pollution emissions and burden. The burden indicators were incidence, deaths and disability-adjusted life years. From 1990 to 2021, the global incidence of UCAs generally declined, with a significant increase observed since 2016. Our analysis identified a positive correlation between burden of UCAs and several air pollutants. Sulfur dioxide(SO₂), ammonia and nitrogen oxides(NO_X) are significantly associated with the incidence of UCAs, while SO₂, NO_X, and non-methane volatile organic compounds are significantly associated with the mortality and disability-adjusted life years rate of UCAs. Sex-specific subgroup analysis indicated differing responses to these pollutants. However, the effect of sulfur dioxide on burden was consistent across sex. Notably, we also found that some pollutants have hysteresis effects that contradict the immediate effects. Additionally, the relationship between air pollution and burden displayed distinct variations over years. This study enhances our understanding of the health impacts on UCAs associated with air pollution, suggested that pregnant women should stay away from ammonia and SO₂. It also emphasizes that strengthening air pollution control should be a key monitoring policy.","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"130 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144066740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Independent and joint effects of volatile organic compounds on pulmonary function in U.S. adults from NHANES: the mediating role of platelet-to-lymphocyte ratio","authors":"Yan-Fei Wei, Hao-Wen Chen, Kuan Liu, Shi-Ao Wang, Wei-Dong Fan, Zhan-Hui Shao, Bi-Fei Cao, Yong-Qi Liang, Zheng-Yun Xu, Kai-Yue Liao, Zi-Xuan Zhao, Lu-Rong Yang, Xin-Ran Deng, Hao-Bang Chen, Xian-Bo Wu","doi":"10.1016/j.envpol.2025.126473","DOIUrl":"https://doi.org/10.1016/j.envpol.2025.126473","url":null,"abstract":"Volatile organic compounds (VOCs) are known to impair pulmonary function. However, the specific VOC with the main significant impact on pulmonary function and the joint effect of combined VOC exposure on pulmonary health, and the underlying mechanisms remain unclear. We used the of data 1,697 participants aged ≥ 18 years old from the National Health and Nutrition Examination Survey 2007-2012. Forced expiratory volume in the first 1.0 second (FEV1), pre-bronchodilator forced vital capacity (FVC), peak expiratory flow rate (PEF) and FEV1/FVC % were used to evaluate pulmonary function. A covariate-adjusted multiple linear regression model evaluated associations between pulmonary function and blood concentrations of seven selected VOCs. Additionally, Bayesian kernel machine regression (BKMR) and weighted quantile sum (WQS) regression were employed to assess combined VOC effects, interactions, and nonlinear dose–response relationships. Parallel mediation analyses explored the mediating role of platelet-to-lymphocyte ratio (PLR) in the associations between VOC mixtures and pulmonary function, utilizing a WQS-derived VOC index. In an analytical sample of 1,697 general adults, the concentrations of blood 1,4-dichlorobenzene, m-/p-xylene, bromodichloromethane, and nitromethane were significantly negatively correlated with pulmonary function, whilst dibromochloromethane was significantly positively correlated with pulmonary function. The joint effect of the seven blood VOCs was also negatively associated with pulmonary function. Particularly, 1,4-dichlorobenzene (PIP = 0.992 for FEV1; 0.998 for FVC) and nitromethane (PIP = 0.990 for FEV1; 1.000 for FVC; 0.845 for PEF) as the most influential VOCs contributing to the overall mixture effect. PLR partially mediated the association between VOC mixtures and pulmonary function, particularly impacting FEV1, FVC, and PEF. This study demonstrated that in addition to chloroform, dibromochloromethane and toluene, the other four blood VOCs were associated with pulmonary function impairment. Their combined exposure effects reflect realistic environmental scenarios. Further research is needed to elucidate the underlying biological mechanisms of these associations.","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":"6 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144066700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}