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Bright Alkyl Quantum Defects Govern Early Carbon Nanotube Pharmacokinetics in Mice 明亮的烷基量子缺陷影响碳纳米管在小鼠体内的早期药代动力学
IF 17.1 1区 材料科学
ACS Nano Pub Date : 2026-11-10 DOI: 10.1021/acsnano.6c15845
Han-Sheng Sun,Ai-Phuong Nguyen,Carlos Jose Quiroz Reyes,Ya Chen Li,Joshua M. Lim,Guan-Wan Liu,Rifqi Fajar Maulana,Ngoc-Khanh Tran,Minh-Thuy Vo,John Ericson Domingo,Tien-Hung Nguyen,Lu-Chih Chen,Marco Raabe,Han-Yuan Yeh,Chih-Hsin Lin,Ya-Ping Hsieh,Yu-Wei Wu,Chi-Ling Chiang,Min-Yeh Tsai,Ching-Wei Lin
{"title":"Bright Alkyl Quantum Defects Govern Early Carbon Nanotube Pharmacokinetics in Mice","authors":"Han-Sheng Sun,Ai-Phuong Nguyen,Carlos Jose Quiroz Reyes,Ya Chen Li,Joshua M. Lim,Guan-Wan Liu,Rifqi Fajar Maulana,Ngoc-Khanh Tran,Minh-Thuy Vo,John Ericson Domingo,Tien-Hung Nguyen,Lu-Chih Chen,Marco Raabe,Han-Yuan Yeh,Chih-Hsin Lin,Ya-Ping Hsieh,Yu-Wei Wu,Chi-Ling Chiang,Min-Yeh Tsai,Ching-Wei Lin","doi":"10.1021/acsnano.6c15845","DOIUrl":"https://doi.org/10.1021/acsnano.6c15845","url":null,"abstract":"Fluorescent quantum defects in single-wall carbon nanotubes (SWCNTs) are a major advance in nanocarbon research, owing to their bright, single-photon emission at telecom wavelengths and versatile conjugation chemistries for biomedical sensing and disease targeting. Here, we introduce an efficient, oxygen-free sonochemical route that generates long-chain alkyl defects, simultaneously shortening nanotubes and producing a bright, homogeneously emissive (6,5) SWCNT ensemble. Among 15 screened reactants, the branched-chain NiaproofⓇ 4, which molecular dynamics simulations show packs more densely and uniformly than linear surfactants, yields a 3.4-fold brightness enhancement and a sharp emission peak near 1108 nm. Single-particle spectroscopy reveals J-aggregate emission redshifts at high defect densities, and fibrinogen titration shows defect chemistry governs protein-driven coating displacement. Using a home-built short-wave infrared imaging system (25 mW cm–2, 989 nm excitation, 1150 nm long-pass collection), we show that these sparse defects (∼9–16 μm–1) drive different pharmacokinetics between NiaproofⓇ 4– and lipid-PEG–functionalized (6,5) at early time points, converging as protein-corona formation masks the underlying chemistry. Histology localizes the nanotubes within macrophages of mononuclear phagocyte system–associated organs. Intravenous administration (∼41 μg kg–1) causes no acute toxicity and a short ∼2-day retention. The NiaproofⓇ 4 group exhibits a reduced circulating myeloid-cell fraction following corona formation, which may reflect organ recruitment and sequestration, while the accompanying increase in CD3+ T cells may partly reflect a proportional shift in leukocyte composition.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"10 2 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2026-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149374644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ultrafast Imaging of Dynamic Disorder in Superionic Chalcocite 超离子辉铜矿动态无序的超快成像
IF 17.1 1区 材料科学
ACS Nano Pub Date : 2026-11-10 DOI: 10.1021/acsnano.6c18235
Ye-Jin Kim,Seok-Hyeon Lee,Chang-Won Choi,Si-Young Choi,Oh-Hoon Kwon
{"title":"Ultrafast Imaging of Dynamic Disorder in Superionic Chalcocite","authors":"Ye-Jin Kim,Seok-Hyeon Lee,Chang-Won Choi,Si-Young Choi,Oh-Hoon Kwon","doi":"10.1021/acsnano.6c18235","DOIUrl":"https://doi.org/10.1021/acsnano.6c18235","url":null,"abstract":"The optimal functionalities of matter often appear at emergent structural orders involving entangled changes in the lattice structures and the underlying atomic degree of freedom. Here, we report laser-induced, thermally driven dynamic structural orders evolving in the low- to high-chalcocite transition of copper(I) sulfide using time-resolved electron diffractometry in ultrafast electron microscopy. We filmed the complete phase trajectory of the transient atomic motions and the hierarchical decoupling of structural orders that unfold over time. Moreover, a transient, disordered state is unveiled. The disordered state emerges during the superionic diffusion of copper ions along a few-nanometer-thick lattice channels. Temporal gating of the various combinations of structure could expand the range of accessible functional states in matter.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"13 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2026-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149374639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Addressable Control of Hybrid Spin Qubit in Single-Atom Copper-Modified Fullerene 单原子铜修饰富勒烯中杂化自旋量子比特的可寻址控制
IF 17.1 1区 材料科学
ACS Nano Pub Date : 2026-11-10 DOI: 10.1021/acsnano.6c14389
Bingcai Chen,Jiahao Chen,Pengxiang Fu,Di Zhang,Hao Li,Jiayue Yuan,Jianyu Liu,Dahui Zhao,Tian Jiang,Gao-Lei Hou,Shanshan Wang,Shen Zhou
{"title":"Addressable Control of Hybrid Spin Qubit in Single-Atom Copper-Modified Fullerene","authors":"Bingcai Chen,Jiahao Chen,Pengxiang Fu,Di Zhang,Hao Li,Jiayue Yuan,Jianyu Liu,Dahui Zhao,Tian Jiang,Gao-Lei Hou,Shanshan Wang,Shen Zhou","doi":"10.1021/acsnano.6c14389","DOIUrl":"https://doi.org/10.1021/acsnano.6c14389","url":null,"abstract":"Developing high-dimensional solid-state quantum technologies requires overcoming the trade-off between spin dimensionality and quantum coherence. Hybrid spin architectures offer a promising solution to expand the quantum state space bottom-up by combining rapid electronic manipulation with robust nuclear phase memory. However, solid-state hybrid spin materials capable of simultaneously supporting both electron and nuclear spin manipulations remain exceedingly rare. Here, we report a Cu2+ (S = 1/2, I = 3/2) hybrid spin system dispersed in a magnetically silent C60 matrix, in which we not only demonstrate comprehensive coherent control over both electron and nuclear spin degrees of freedom but also strike a balance between spin dimensionality and coherence time. The pristine carbon environment suppresses surrounding magnetic noise, acting in tandem with dynamical decoupling to prolong the electron spin coherence time to 16.16 μs. Simultaneously, the nuclear quadrupole interaction of Cu2+ breaks the degeneracy of the nuclear spin manifold, enabling precise addressability of an eight-dimensional Hilbert space. Furthermore, strong electron–nuclear hyperfine coupling acts as a powerful lever, accelerating the nuclear spin Rabi frequency by a factor of 17. By achieving the coexistence of a large manifold of addressable levels and long-lived quantum coherence, Cu/C60 provides a high-dimensional hybrid spin node and a compelling bottom-up approach to expanding the quantum state space.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"7 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2026-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149374646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Attempts to Understand and Manipulate the Orientation and Retention of Peptides Inside Nanopores Expand the Toolbox for Nanopore-Based Proteomics 试图理解和操纵纳米孔内多肽的取向和保留扩展了纳米孔蛋白质组学的工具箱
IF 17.1 1区 材料科学
ACS Nano Pub Date : 2026-11-10 DOI: 10.1021/acsnano.6c12868
Xing Wei,Xinpei Wang,Dan Liu,Yuxi Shao,Gang Huang
{"title":"Attempts to Understand and Manipulate the Orientation and Retention of Peptides Inside Nanopores Expand the Toolbox for Nanopore-Based Proteomics","authors":"Xing Wei,Xinpei Wang,Dan Liu,Yuxi Shao,Gang Huang","doi":"10.1021/acsnano.6c12868","DOIUrl":"https://doi.org/10.1021/acsnano.6c12868","url":null,"abstract":"Nanopore techniques have emerged as promising tools for deciphering complex proteomics from the single-molecule level by profiling individual peptides. The entry orientation of a peptide and its subsequent retention inside the nanopore are crucial for the analytical results but remain challenging to be properly defined, which limits the sensing capability of nanopore-based proteomics technology. Here, we propose that electrically driving peptide entry into α-hemolysin nanopores against opposing electroosmotic flows is a promising platform to guide the polypeptide with a preferential orientation. α-Hemolysin mutants with opposite ion selectivity have been engineered and employed to measure peptides at pH 3.8 and at alkaline pH exceeding 10.0. The impact of peptide charge distribution on the orientation has been investigated by simulating the peptide dipole moment and electrophysiology measurements. In addition, the retention position of the peptide has been altered by introducing tryptophan residues at position 125 within the β-barrel region of α-hemolysin, which increases the sensitivity for specific peptide region and enables the detection of initially inaccessible monomethylation modifications. Thus, we present a rational framework to investigate and manipulate the orientation and dwelling position of peptides inside the α-hemolysin nanopore, which can enhance our capability to profile polypeptides by using nanopore techniques.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"8 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2026-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149374638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ultrafast High-Photogain UV–Vis-NIR Broadband Photodetection in Parallelly Overlapped Stacking Type-I GaSe/MoTe2 Heterostructure 平行重叠堆叠i型GaSe/MoTe2异质结构的超快高光增益紫外-可见-近红外宽带光探测
IF 17.1 1区 材料科学
ACS Nano Pub Date : 2026-11-10 DOI: 10.1021/acsnano.6c13428
Vijay Laxmi,Yutao Hu,Pushpendra Yadav,Danting Lin,Deepika Tyagi,Yuting Sun,Claudia Draxl,Wenjing Zhang,Yudi Tu,Yibin Tian
{"title":"Ultrafast High-Photogain UV–Vis-NIR Broadband Photodetection in Parallelly Overlapped Stacking Type-I GaSe/MoTe2 Heterostructure","authors":"Vijay Laxmi,Yutao Hu,Pushpendra Yadav,Danting Lin,Deepika Tyagi,Yuting Sun,Claudia Draxl,Wenjing Zhang,Yudi Tu,Yibin Tian","doi":"10.1021/acsnano.6c13428","DOIUrl":"https://doi.org/10.1021/acsnano.6c13428","url":null,"abstract":"Broadband photodetectors are important for next-generation optoelectronic applications, ranging from fundamental science, environmental monitoring, industrial detection to artificial-intelligence-enabled Internet of Things systems, where both high responsivity and fast response are critically demanded. Typically, a trade-off exists between the two in the photogating effect, making it challenging to achieve both simultaneously. This study reports a parallelly overlapped stacking GaSe/MoTe2 heterostructure with type-I band alignment (PSH-GM), which simultaneously realizes an ultrafast photoresponse of 523 ns and a high responsivity of 8.95 × 103 A·W–1, together with a noise equivalent power of ∼0.38 × 10–14 W·Hz–1/2 and a specific detectivity of 8.01 × 1011 Jones. Furthermore, PSH-GM exhibits a responsivity of up to 103 A·W–1 over a broad spectral range of 355–1100 nm, covering the ultraviolet (UV), visible (Vis), and near-infrared (NIR) regions. The underlying photodetection mechanism of the parallelly overlapped stacking type-I heterostructure is clarified using photocurrent mapping, and the origin of the dark current shift at different operation frequencies is elucidated, both of which offer insights into the design principles of two-dimensional heterostructures optimized to simultaneously achieve high responsivity and high response bandwidth. Imaging demonstrations are conducted at 355, 520, and 850 nm, and free-space optical communication is demonstrated at 115.2 kbit·s–1, which highlights the potential of PSH-GM for broadband UV–Vis–NIR photodetection, ultrafast data communication, high-speed imaging, and integration into advanced optoelectronic systems.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"20 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2026-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149374645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Charge-Induced Formation and Field-Driven Directional Motion of Vacancies in a Two-Dimensional Halide 二维卤化物中电荷诱导的空位形成和场驱动的定向运动
IF 17.1 1区 材料科学
ACS Nano Pub Date : 2026-11-10 DOI: 10.1021/acsnano.6c11067
Lucia Vitali,Duy Le,Talat S. Rahman
{"title":"Charge-Induced Formation and Field-Driven Directional Motion of Vacancies in a Two-Dimensional Halide","authors":"Lucia Vitali,Duy Le,Talat S. Rahman","doi":"10.1021/acsnano.6c11067","DOIUrl":"https://doi.org/10.1021/acsnano.6c11067","url":null,"abstract":"Controlling defect evolution in two-dimensional (2D) materials is essential for reliable nanoelectronic functionalities, yet selectively inducing defect formation and externally driven migration remains a key challenge. Here, we demonstrate two distinct mechanisms governing halogen vacancy formation and migration in a PbBr2 monolayer on highly ordered pyrolytic graphite using low-temperature scanning tunneling microscopy combined with density functional theory calculations. We show that halogen vacancies reshape the local density of states and electrostatic potential beyond the immediate defect site. Crucially, electric fields and charge injection mediate distinct atomic-scale responses: tip-induced electric fields drive directional vacancy migration and coalescence, whereas charge injection from the tunneling current induces vacancy formation, with enhanced efficiency when coupling to shallow defect states. These results demonstrate that direct electrical stimuli can drive both vacancy motion and creation in a two-dimensional, predominantly ionic material system. Our findings establish a framework linking defect-induced electronic structure, local electrostatics, and externally driven atomic rearrangement under conditions relevant to device operation.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"240 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2026-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149374657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Truly Asynchronous and One-Hot Constraint Probabilistic Potts Computing with Floating-Body Metal–Oxide–Semiconductor Field-Effect Transistors 浮体金属氧化物半导体场效应晶体管的真正异步单热约束概率波计算
IF 17.1 1区 材料科学
ACS Nano Pub Date : 2026-11-10 DOI: 10.1021/acsnano.6c07659
Sunwoo Cheong,Jun-Young Park,Janguk Han,Cheol Seong Hwang,Joon-Kyu Han
{"title":"Truly Asynchronous and One-Hot Constraint Probabilistic Potts Computing with Floating-Body Metal–Oxide–Semiconductor Field-Effect Transistors","authors":"Sunwoo Cheong,Jun-Young Park,Janguk Han,Cheol Seong Hwang,Joon-Kyu Han","doi":"10.1021/acsnano.6c07659","DOIUrl":"https://doi.org/10.1021/acsnano.6c07659","url":null,"abstract":"This work presents a truly asynchronous physical Potts node (TAPPN) using floating-body metal–oxide–semiconductor field-effect transistors (FB-MOSFETs) to overcome the scalability and encoding overhead limitations of binary Ising-based probabilistic computing. The TAPPN enables native multistate representation without external random-number generators (RNGs) or complex digital arbitration by the intrinsic stochastic single-transistor latch (STL) effect and a drain-sharing configuration. The stochastic source and the one-hot constraint are realized by three transistors, and the node requires 25 transistors and 220 nW including the readout, compared with 2160 transistors and 52 μW for a self-contained digital node evaluated at the same boundary. Its truly asynchronous operation allows efficient exploration of the problem space in large-scale graph-coloring benchmarks. In simulations of the update rule, the Potts-based system achieves a higher success probability than simulated annealing (SA) and parallel tempering (PT) on graph-coloring benchmarks. For an integrated array assumed to operate at 5 MHz, the architecture is projected to reach a time-to-solution (TTS) of 3.4 μs and an energy-to-solution (ETS) of 504 nJ. This platform establishes a complementary metal–oxide–semiconductor (CMOS)-compatible pathway toward large-scale, multistate combinatorial optimization.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"16 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2026-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149374642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Self-Assembly of Two-Dimensional Open Structures with Adjustable Square Voids 具有可调方形空隙的二维开放结构的自组装
IF 17.1 1区 材料科学
ACS Nano Pub Date : 2026-11-10 DOI: 10.1021/acsnano.6c13668
Denis Dertli,Na Liu,Thomas Speck
{"title":"Self-Assembly of Two-Dimensional Open Structures with Adjustable Square Voids","authors":"Denis Dertli,Na Liu,Thomas Speck","doi":"10.1021/acsnano.6c13668","DOIUrl":"https://doi.org/10.1021/acsnano.6c13668","url":null,"abstract":"Self-assembly of anisotropic particles offers a powerful route to design materials with tailored microstructures. Here we investigate two-dimensional systems of patchy hard rectangles using Monte Carlo simulations and free volume theory, mapping their phase diagram across packing fractions and interaction strengths. Low attraction recovers excluded-volume phase behavior (isotropic–tetratic–smectic), while intermediate attraction strengths feature a broad isotropic–smectic coexistence region. For high interaction strengths our theory predicts, and simulations confirm, a highly ordered “weaver” phase characterized by a four-rectangle unit cell that forms a regular grid of square voids. Although the pure weaver phase forms only in a narrow window of packing fractions, it coexists with either the isotropic gas or smectic solid over a wide range of packing fractions. Patchy rectangles demonstrate how shape together with tunable interactions can be utilized to self-assemble porous materials with precisely adjustable void sizes and geometries and could be realized using DNA origami structures.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"24 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2026-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149374640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Breaking the Capacity–Stability Trade-Off in High-Voltage LiCoO2 via Opposite Co/O Redox Activity 通过反向Co/O氧化还原活性打破高压LiCoO2的容量-稳定性权衡
IF 17.1 1区 材料科学
ACS Nano Pub Date : 2026-11-10 DOI: 10.1021/acsnano.6c15741
Mengjie Zhang,Yulin Cao,Lingfeng Shi,Ruichen Zhu,Yehang Dou,Fangchang Zhang,Yanfang Wang,Ke Li,Chun Zeng,Xueyan Zhang,Liguang Wang,Zhouguang Lu,Hua Huo
{"title":"Breaking the Capacity–Stability Trade-Off in High-Voltage LiCoO2 via Opposite Co/O Redox Activity","authors":"Mengjie Zhang,Yulin Cao,Lingfeng Shi,Ruichen Zhu,Yehang Dou,Fangchang Zhang,Yanfang Wang,Ke Li,Chun Zeng,Xueyan Zhang,Liguang Wang,Zhouguang Lu,Hua Huo","doi":"10.1021/acsnano.6c15741","DOIUrl":"https://doi.org/10.1021/acsnano.6c15741","url":null,"abstract":"LiCoO2 (LCO) suffers from daunting capacity–stability trade-off due to deeper Co oxidation and ensuing O oxidation (O2– → Co4+ electron transfer) at high-voltage (≥4.5 V). Aggressive Co4+ and O2/On– (0 < n < 2) species result in pronounced mechanical/chemical failure and fast capacity decay. Most of the state-of-the-art solutions partially resolve these problems yet sacrificing capacity. Herein, facilitated Co3+/4+ redox and effectively restrained O redox are simultaneously achieved by amplifying Co t2g electron density of states (DOS) near the Fermi level while reducing O 2p electron DOS. Consequently, the engineered cathode harvests a remarkable initial capacity of 212.1 mAh g–1 at 4.6 V (vs 212.9 mAh g–1 of bare LCO). Moreover, advanced multiscale X-ray/electron spectroscopy and imaging techniques reveal that mitigated O redox prevents irreversible phase transitions, lattice O loss, and undesirable surface parasitic reactions. As a result, the cathode has reinforced electrochemical (capacity retention of 88.4% within 330 cycles at 5C) and thermal stability thanks to fatigue-free (de)lithiation channels, less new-generated Co3O4 layer, and inorganic-rich cathode/electrolyte interphase (CEI) film. This work provides a valuable inspiration for the electronic structure engineer of robust LCO cathode toward high operation voltages.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"10 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2026-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149374641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biomimetic Nanozyme-Decoys Reprogram Immune Niches to Intercept Colitis-Carcinoma Transition 仿生纳米酶-诱饵重编程免疫龛拦截结肠炎-癌转移
IF 17.1 1区 材料科学
ACS Nano Pub Date : 2026-11-10 DOI: 10.1021/acsnano.6c16014
Qi Sun,Wanling Liu,Sijie Li,Xiwen Chen,Hanjie Zhang,Dongze Mo,Pinwen Zhou,Xiaomiao Cui,Di Huang,Bing Xia,Jingjing Zhang,Xinying Wang,Xiaoyu Wang,Hui Wei
{"title":"Biomimetic Nanozyme-Decoys Reprogram Immune Niches to Intercept Colitis-Carcinoma Transition","authors":"Qi Sun,Wanling Liu,Sijie Li,Xiwen Chen,Hanjie Zhang,Dongze Mo,Pinwen Zhou,Xiaomiao Cui,Di Huang,Bing Xia,Jingjing Zhang,Xinying Wang,Xiaoyu Wang,Hui Wei","doi":"10.1021/acsnano.6c16014","DOIUrl":"https://doi.org/10.1021/acsnano.6c16014","url":null,"abstract":"Colitis-associated colorectal cancer (CAC) arises from chronic inflammatory niches characterized by persistent oxidative stress and dysregulated immune cell recruitment. Current anti-inflammatory therapies provide only transient symptom relief and fail to prevent malignant progression due to their inability to simultaneously mitigate oxidative injury and immune chemotaxis. Our analysis of clinical samples revealed markedly elevated C-X-C motif chemokine ligand 2 (CXCL2) in intestinal tissues from patients with inflammatory bowel disease and CAC, implicating the CXCL2-CXCR2 (C-X-C motif chemokine receptor 2) axis in driving excessive neutrophil and macrophage infiltration and fostering tumorigenesis. Herein, we report a biomimetic nanozyme (PB@ECM) that reprograms inflammatory immune niches to intercept CAC progression. PB@ECM integrates a Prussian blue nanozyme core with genetically engineered macrophage membranes, enabling concurrent scavenging of reactive oxygen species through superoxide dismutase- and catalase-like activities and sequestration of CXCL2 via membrane-displayed CXCR2 receptors. In murine models of colitis and CAC, PB@ECM significantly alleviated intestinal inflammation, suppressed neutrophil and macrophage infiltration, and effectively inhibited colitis-carcinoma transition. Notably, treatment with PB@ECM significantly prolonged survival compared with other groups. By disrupting the pathological crosstalk between oxidative stress and immune chemotaxis, this work establishes a biomimetic nanozyme strategy for preventing inflammation-driven carcinogenesis.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"194 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2026-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149374648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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