IF 17.1 1区材料科学

ACS Nano Pub Date : 2025-05-06 DOI: 10.1021/acsnano.4c16628

Yan Liu, Xinyue Ran, Guangdong Zhou, Yingbin Liu, Weihong Tan

{"title":"Multivalent Aptamer Assembly Enhances Tumor-Specific Degradation of Transforming Growth Factor-Beta to Remodel the Stromal and Immunosuppressive Cancer Microenvironment","authors":"Yan Liu, Xinyue Ran, Guangdong Zhou, Yingbin Liu, Weihong Tan","doi":"10.1021/acsnano.4c16628","DOIUrl":"https://doi.org/10.1021/acsnano.4c16628","url":null,"abstract":"Extracellular proteins like transforming growth factor-β (TGFβ) are crucial enforcers in the development of cancer stroma and the tumor immunosuppressive microenvironment. Lysosome-targeting chimera-mediated protein degradation appeared as a promising tool for extracellular signal interference but was limited by several lysosome-trafficking receptors and inadequate in vivo degradation efficiency. Here, we designed a multivalent aptamer assembly with a universal pattern to drag extracellular proteins (e.g., TGFβ1) for lysosome degradation with high tumor specificity. By accelerating cell recognition-internalization and lysosomal delivery, the assembly promoted TGFβ blockade and degradation in pancreatic cancer cells and pancreatic stellate cells (PSCs). In vivo, the assembly exhibited highly tumor-specific accumulation and prolonged retention, which resulted in efficient TGFβ inhibition, stromal remodeling, and reversed polarization of immunosuppressive cells in the tumor microenvironment, as well as synergic therapeutic effects when combined with gemcitabine or ovalbumin. Therefore, this study provides a feasible strategy to construct a multivalent aptamer assembly for tumor-specific extracellular protein degradation, after remodeling the tumor stromal and immunosuppressive microenvironment in a manner that enhances the effects of cancer chemotherapy and immunotherapy.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"19 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143910728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reproducible Transpalpebral Intraocular Pressure Sensing Enabled by Low-Energy-Barrier Ion Pumping 低能量势垒离子泵可实现可重复的经睑眼内压感应

IF 17.1 1区材料科学

ACS Nano Pub Date : 2025-05-06 DOI: 10.1021/acsnano.5c02762

Xueyang Ren, Xuefei Zhu, Xiaodong Shao, Wen Yang, Yanmei Meng, Shiyu Chen, Yannan Wang, Jianqing Li, Qin Jiang, Benhui Hu

{"title":"Reproducible Transpalpebral Intraocular Pressure Sensing Enabled by Low-Energy-Barrier Ion Pumping","authors":"Xueyang Ren, Xuefei Zhu, Xiaodong Shao, Wen Yang, Yanmei Meng, Shiyu Chen, Yannan Wang, Jianqing Li, Qin Jiang, Benhui Hu","doi":"10.1021/acsnano.5c02762","DOIUrl":"https://doi.org/10.1021/acsnano.5c02762","url":null,"abstract":"Elevated intraocular pressure (IOP) is a major risk factor for blindness in glaucoma patients, highlighting the critical need for continuous IOP monitoring. While traditional transpalpebral tonometers (TTs) circumvent corneal contact by adopting Goldmann applanation principles through impulsive corneal flattening forces, their measurement accuracy is inherently compromised by eyelid-induced cushion effects. In contrast, parallel-plate capacitive sensors employ constant compressive loading upon the eyelid, achieving palpebral compaction to mitigate the cushion effects. More recently, ion-pump-based capacitive sensors have emerged as promising alternatives, particularly due to their enhanced sensitivity. Nevertheless, these sensors exhibit sharp sensitivity deterioration at extended measurement ranges (0–10 kPa). This operational constraint originates from the strong hydrogen bond energies (between confining matrices and ions) and rigid block copolymer matrices’ steric hindrance. To address these limitations, we developed a transpalpebral tonometer featuring low-energy-barrier ion pumps, incorporating (3-aminopropyl)triethoxysilane (APTES)-silanized liquid metal nanoparticles (LM NPs) as confining matrices and an ionic liquid as an ion donor. The low-energy barrier arises from (1) weaker hydrogen bonds between the N–H of APTES and the F of the ionic liquid and (2) reduced crystallinity in the elastomeric matrices induced by LM NPs. Our sensor achieves a sensitivity of 24.88 kPa–1 with maintained linearity over 0–85 kPa. In vivo animal trials over 120 min validated its continuous IOP monitoring capability, reliably detecting elevated IOP states and demonstrating clinical potential for glaucoma management.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"74 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143910780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multiphoton-Excited Upconversion Luminescence and Amplified Spontaneous Emission from Te4+-Doped Cs2SnCl6 Nanocrystals Te4+掺杂Cs2SnCl6纳米晶体的多光子激发上转换发光和放大自发发射

IF 17.1 1区材料科学

ACS Nano Pub Date : 2025-05-06 DOI: 10.1021/acsnano.5c05992

Wei Zhang, Wei Zheng, Lingyun Li, Xiaoying Shang, Ping Huang, Xiaodong Yi, Hao Zhang, Yan Yu, Xueyuan Chen

{"title":"Multiphoton-Excited Upconversion Luminescence and Amplified Spontaneous Emission from Te4+-Doped Cs2SnCl6 Nanocrystals","authors":"Wei Zhang, Wei Zheng, Lingyun Li, Xiaoying Shang, Ping Huang, Xiaodong Yi, Hao Zhang, Yan Yu, Xueyuan Chen","doi":"10.1021/acsnano.5c05992","DOIUrl":"https://doi.org/10.1021/acsnano.5c05992","url":null,"abstract":"High-order nonlinear multiphoton absorption (MPA) is technologically important for a variety of photonic and biological applications owing to its superior advantages over linear absorption and low-order MPA such as greater spatial confinement, larger penetration depth, reduced autofluorescence, and enhanced imaging resolution. However, practical implementation beyond three-photon processes remains notoriously difficult due to the sharp reduction of absorption cross sections with increasing nonlinearity and inherent material instability under high-density irradiation. Herein, we address these challenges through rationally designed Te4+-doped Cs2SnCl6 nanocrystals (NCs), which demonstrate wideband nonlinear responsiveness across 800–2600 nm, allowing achievement of two- to seven-photon absorption (PA) with cross sections outperforming conventional nonlinear optical materials. Particularly, the engineered NCs enable 3PA-excited amplified spontaneous emission (ASE) with an ultralow excitation threshold of 0.22 μJ cm–2 under a 1300 nm femtosecond-pulsed laser excitation, representing 1–4 orders of magnitude improvement compared to existing nonlinear ASE systems. This work presents the excellent 7PA properties in metal halide NCs, positioning lead-free metal halide NCs promising as efficient light-emitting materials for extreme nonlinear nanophotonics.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"11 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143910781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quantum and Classical Exceptional Points at the Nanoscale: Properties and Applications 纳米尺度上的量子和经典异常点：性质和应用

IF 17.1 1区材料科学

ACS Nano Pub Date : 2025-05-06 DOI: 10.1021/acsnano.4c15648

Yu-Wei Lu, Wei Li, Xue-Hua Wang

{"title":"Quantum and Classical Exceptional Points at the Nanoscale: Properties and Applications","authors":"Yu-Wei Lu, Wei Li, Xue-Hua Wang","doi":"10.1021/acsnano.4c15648","DOIUrl":"https://doi.org/10.1021/acsnano.4c15648","url":null,"abstract":"Exceptional points (EPs) are the spectral singularities and one of the central concepts of non-Hermitian physics, originating from the inevitable energy exchange with the surrounding environment. EPs exist in diverse physical systems and give rise to many counterintuitive effects, offering rich opportunities to control the dynamics and alter the properties of optical, electronic, acoustic, and mechanical states. The last two decades have witnessed the flourishing of non-Hermitian physics and associated applications related to coalesced eigenstates at EPs in a plethora of classical systems. While stemming from the quantum mechanism, the implementation of EPs in real quantum systems still faces challenges of tuning and stabilizing the systems at EPs, as well as the additional noises that hinder the observation of relevant phenomena. This review mainly focuses on summarizing the current efforts and opportunities offered by quantum EPs that result from or produce observable quantum effects. We introduce the concepts of Hamiltonian and Liouvillian EPs in the quantum regime and focus on their different properties in connection with quantum jumps and decoherence. We then provide a comprehensive discussion covering the theoretical and experimental advances in accessing EPs in diverse quantum systems and platforms. Special attention is paid to EP-based quantum-optics applications with state-of-art technologies. Finally, we present a discussion on the existing challenges of constructing quantum EPs at the nanoscale and an outlook on the fundamental science and applied technologies of quantum EPs, aiming to provide valuable insights for future research and building quantum devices with high performance and advanced functionalities.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"3 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143910777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Broadband-Responsive Rubbery Stretchable Vertical-Structured Photodetectors Based on Rubbery Stretchable Transparent Conductors 基于橡胶可拉伸透明导体的宽带响应橡胶可拉伸垂直结构光电探测器

IF 17.1 1区材料科学

ACS Nano Pub Date : 2025-05-06 DOI: 10.1021/acsnano.5c01015

Junmei Hu, Wei-Chen Gao, Yu-Dong Zhao, Ben Fan, Xiang Sun, Jing Qiao, Ying-Shi Guan, Quan Li

{"title":"Broadband-Responsive Rubbery Stretchable Vertical-Structured Photodetectors Based on Rubbery Stretchable Transparent Conductors","authors":"Junmei Hu, Wei-Chen Gao, Yu-Dong Zhao, Ben Fan, Xiang Sun, Jing Qiao, Ying-Shi Guan, Quan Li","doi":"10.1021/acsnano.5c01015","DOIUrl":"https://doi.org/10.1021/acsnano.5c01015","url":null,"abstract":"A rubbery stretchable conductor with high conductivity and transparency is crucial for the development of rubbery stretchable vertical-structured photodetectors. However, the development of such a rubbery conductor is still nascent. Here, we report the scalable manufacturing of rubbery stretchable transparent conductors (RSTCs) and the development of a rubbery stretchable vertical-structured photodetector (RSVPD). The RSTC is fabricated into a specialized micromesh structure by utilizing a close-packed monolayer of polystyrene microspheres as a mask. The micromesh structure not only enhances the conductor’s stretchability and transparency but also maintains its conductivity, making it ideal for various applications in stretchable electronics. The RSTCs are used to construct RSVPDs that have high response over a broad spectrum, and their electrical performances can be retained even when subjected to mechanical strains of up to 50%. Furthermore, a stretchable imager based on RSVPD was developed to detect the multipoint light distribution. Lastly, a photoplethysmography (PPG) sensor was also developed for real-time health monitoring.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"50 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143910778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spatial and Temporal Single-Cell Profiling of RNA Compartmentalization in Neurons with Nanotweezers 纳米镊子对神经元中RNA区隔化的时空单细胞分析

IF 17.1 1区材料科学

ACS Nano Pub Date : 2025-05-06 DOI: 10.1021/acsnano.5c02056

Annie Sahota, Binoy Paulose Nadappuram, Zoe Kwan, Flavie Lesept, Jack H. Howden, Suzanne Claxton, Josef T. Kittler, Michael J. Devine, Joshua B. Edel, Aleksandar P. Ivanov

{"title":"Spatial and Temporal Single-Cell Profiling of RNA Compartmentalization in Neurons with Nanotweezers","authors":"Annie Sahota, Binoy Paulose Nadappuram, Zoe Kwan, Flavie Lesept, Jack H. Howden, Suzanne Claxton, Josef T. Kittler, Michael J. Devine, Joshua B. Edel, Aleksandar P. Ivanov","doi":"10.1021/acsnano.5c02056","DOIUrl":"https://doi.org/10.1021/acsnano.5c02056","url":null,"abstract":"Emerging techniques for mapping mRNAs within the subcellular compartments of live cells hold great promise for advancing our understanding of the spatial distribution of transcripts and enabling the study of single-cell dynamics in health and disease. This is particularly critical for polarized cells, such as neurons, where mRNA compartmentalization is essential for regulating gene expression, and defects in these localization mechanisms are linked to numerous neurological disorders. However, many subcellular analysis techniques require a compromise between subcellular precision, live-cell measurements, and nondestructive access to single cells in their native microenvironment. To overcome these challenges, we employ a single-cell technology that we have recently developed, the nanotweezer, which features a nanoscale footprint (∼100 nm), avoids cytoplasmic fluid aspiration, and enables rapid RNA isolation from living cells with minimal invasiveness. Using this tool, we investigate single-cell mRNA compartmentalization in the soma and dendrites of hippocampal neurons at different stages of neuronal development. By combining precise targeting with sequential sampling, we track changes in mRNA abundance at dendritic spine regions of the same neuron, both before and after stimulation. This minimally invasive approach enables time-resolved, subcellular gene expression profiling of the same single cell. This could provide critical insights into polarized cells and advance our understanding of biological processes and complex diseases.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"31 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143910779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Hierarchical Contact–Electrification Interface Based on Gradient Micro-/Nanostructured Hydrogel for Cardiovascular Disease Monitoring 基于梯度微/纳米结构水凝胶的分层接触-电气化界面用于心血管疾病监测

IF 17.1 1区材料科学

ACS Nano Pub Date : 2025-05-05 DOI: 10.1021/acsnano.5c00313

Zhenqiu Gao, Liming Zhang, Hao Lei, Yina Liu, Haicheng Gu, Lingjie Xie, Bohan Lu, Haifeng Ji, Zhen Wen, Xuhui Sun

{"title":"A Hierarchical Contact–Electrification Interface Based on Gradient Micro-/Nanostructured Hydrogel for Cardiovascular Disease Monitoring","authors":"Zhenqiu Gao, Liming Zhang, Hao Lei, Yina Liu, Haicheng Gu, Lingjie Xie, Bohan Lu, Haifeng Ji, Zhen Wen, Xuhui Sun","doi":"10.1021/acsnano.5c00313","DOIUrl":"https://doi.org/10.1021/acsnano.5c00313","url":null,"abstract":"Accurate monitoring of pulses is essential for assessing cardiovascular health. However, the specificity of the pulse wave depends on prestress applied to a wearable sensor. Here, we introduce a progressive contact area compensation strategy, which greatly extends the detection range of the sensor’s high-sensitivity region. It features a hierarchical flower surface structure and a gradient micro-/nanostructured hydrogel as the dielectric layer, compensating for the output decrease resulting from pressure hardening by gradually increasing the contact area between the contact–electrification interfaces. Consequently, the gradient micro-/nanostructured hydrogel, fabricated via electric field induction, enables the sensor’s high-sensitivity region to reach 1.1–52.2 kPa, a 5-fold improvement over that of comparable sensors. By integrating prestress adaptive units, signal processing modules, and a peak seeking algorithm, we develop a wireless wristband for continuous monitoring of cardiovascular status and blood pressure. Importantly, a preliminary 10 day blood pressure test on 22 volunteers showed an error margin of less than ±5 mm Hg, demonstrating its potential as a cardiovascular health product.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"76 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143905651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High-Efficiency Electrochemical Ammonia Synthesis at Co-Catalytic Fe–Mo Dual-Atom Sites Fe-Mo双原子催化下的高效电化学氨合成

IF 17.1 1区材料科学

ACS Nano Pub Date : 2025-05-05 DOI: 10.1021/acsnano.5c01741

Ruonan Li, Runlin Ma, Li-Li Zhang, Wei Ma, Gonglei Shao, Xu Zhang, Yun Tian, Menggai Jiao, Zhen Zhou

{"title":"High-Efficiency Electrochemical Ammonia Synthesis at Co-Catalytic Fe–Mo Dual-Atom Sites","authors":"Ruonan Li, Runlin Ma, Li-Li Zhang, Wei Ma, Gonglei Shao, Xu Zhang, Yun Tian, Menggai Jiao, Zhen Zhou","doi":"10.1021/acsnano.5c01741","DOIUrl":"https://doi.org/10.1021/acsnano.5c01741","url":null,"abstract":"To tackle the challenge in electrochemical nitrogen fixing and reduction in aqueous electrolytes, the conventional approach has been to suppress the competitive hydrogen evolution reaction. Nonetheless, proton provision is a crucial step in the nitrogen reduction pathway to produce ammonia, and a single active site faces the daunting task in striking a balance between high nitrogen fixation efficiency and fast protonation kinetics. This work presents a harmonic strategy featuring atomically dispersed dual Fe–Mo sites anchored in an N-doped carbon (FeMoNC) substrate, where a low-spin Fe center with enriched empty d orbitals aids in nitrogen fixation and activation, and the adjacent Mo site accelerates the protonation kinetics of N-containing intermediates at the Fe site via a distal associative mechanism. Driven by this co-catalytic mechanism, the FeMoNC catalyst achieves a Faradaic efficiency of 37.42%, marking a significant improvement of 7.8- and 10.6-fold over Fe or Mo single-atom catalysts, respectively. Furthermore, an excellent NH3 yield of 54.40 μg h–1 mgcat.–1 is realized in a flow cell by enhancing mass transfer. This study provides valuable insights into diatomic co-catalytic mechanisms for electrochemical ammonia synthesis.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"93 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143905646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Remodeling the Senescent Microenvironment for Promoting Osteoporotic Tendon-to-Bone Healing via Synergizing Senolytic Quercetin and Aligned Nanowire-Structured Hydrogels 通过协同抗衰老槲皮素和排列纳米线结构水凝胶，重塑衰老微环境促进骨质疏松肌腱到骨愈合

IF 17.1 1区材料科学

ACS Nano Pub Date : 2025-05-05 DOI: 10.1021/acsnano.5c01332

Wei Song, Wencai Liu, Si-Yi Li, Yuhao Yu, Hui Xu, Tingwang Shi, Han-Ping Yu, Yaohua He, Ying-Jie Zhu, Weilin Yu

{"title":"Remodeling the Senescent Microenvironment for Promoting Osteoporotic Tendon-to-Bone Healing via Synergizing Senolytic Quercetin and Aligned Nanowire-Structured Hydrogels","authors":"Wei Song, Wencai Liu, Si-Yi Li, Yuhao Yu, Hui Xu, Tingwang Shi, Han-Ping Yu, Yaohua He, Ying-Jie Zhu, Weilin Yu","doi":"10.1021/acsnano.5c01332","DOIUrl":"https://doi.org/10.1021/acsnano.5c01332","url":null,"abstract":"Osteoporotic tendon-to-bone healing remains a major challenge, as cellular senescence disrupts tissue regeneration and impairs repair outcomes. Although the role of cellular senescence in rotator cuff repair is increasingly recognized, current strategies often overlook the complex pathological context, particularly the dual impacts of senescence on both bone marrow-derived mesenchymal stem cells (BMSCs) and tendon-derived stem cells (TDSCs). This gap hampers effective tendon-to-bone healing and integration, especially under osteoporotic conditions. Herein, a composite hydrogel system, quercetin-loaded aligned ultralong hydroxyapatite nanowire/gelatin-hyaluronic acid hydrogel (Que-AHNW/GH), has been developed to address these challenges. By integrating senolytic quercetin as a biological cue with highly aligned ultralong hydroxyapatite (HAP) nanowires as a topographical cue, the system remodels the senescent microenvironment, alleviating senescence in both BMSCs and TDSCs and promoting osteogenesis and tenogenesis. Que-AHNW/GH suppresses the PI3K/AKT pathway, enhances autophagy, and reduces senescence in both cell types. In vivo, Que-AHNW/GH improves bone tunnel regeneration, tendon repair, and tendon-to-bone integration in osteoporotic rats with rotator cuff injury. This system enhances biomechanical strength and gait performance and demonstrates excellent biosafety. These findings highlight the promising potential of Que-AHNW/GH as a multifunctional biomaterial for effectively promoting senescence-related tendon-to-bone healing, offering a promising solution for treating osteoporotic tendon-to-bone injuries.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"31 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143910729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to “Tumor Microenvironment-Activatable Nanosystem Capable of Overcoming Multiple Therapeutic Obstacles for Augmenting Immuno/Metal-Ion Therapy” 修正“肿瘤微环境可激活纳米系统能够克服增强免疫/金属离子治疗的多重治疗障碍”

IF 17.1 1区材料科学

ACS Nano Pub Date : 2025-05-05 DOI: 10.1021/acsnano.5c06637

Qian Cheng, Xiaolei Shi, Yuzhe Chen, Qilin Li, Jiawei Wang, Heli Li, Lin Wang, Zheng Wang

引用次数: 0

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