ACS Nano最新文献

Photosensitive Hybrid γδ-T Exosomes for Targeted Cancer Photoimmunotherapy

IF 17.1 1区材料科学

ACS Nano Pub Date : 2025-01-25 DOI: 10.1021/acsnano.4c11024

Yifan Gao, Jinzhao Liu, Meicen Wu, Yanmei Zhang, Manni Wang, Qingyang Lyu, Wenyue Zhang, Yang Zhou, Yin Celeste Cheuk, Xiwei Wang, Yinping Liu, Weiping Wang, Wenwei Tu

{"title":"Photosensitive Hybrid γδ-T Exosomes for Targeted Cancer Photoimmunotherapy","authors":"Yifan Gao, Jinzhao Liu, Meicen Wu, Yanmei Zhang, Manni Wang, Qingyang Lyu, Wenyue Zhang, Yang Zhou, Yin Celeste Cheuk, Xiwei Wang, Yinping Liu, Weiping Wang, Wenwei Tu","doi":"10.1021/acsnano.4c11024","DOIUrl":"https://doi.org/10.1021/acsnano.4c11024","url":null,"abstract":"Melanoma is the most aggressive type of skin cancers. Traditional chemotherapy and radiotherapy have limited effectiveness and can lead to systemic side effects. Photodynamic therapy (PDT) is a photoresponsive cancer therapy based on photosensitizers to generate reactive oxygen species (ROS) to eradicate tumor cells. Our previous study showed that exosomes derived from human γδ-T cells (γδ-T exosomes) could control Epstein–Barr virus-associated tumors. Here, we combined γδ-T exosomes and PDT for targeted photoimmunotherapy by membrane fusion of γδ-T exosomes and Chlorin e6 (Ce6)-loaded liposomes. The functional surface proteins, such as CCR5 and PD-1, on the hybrid exosomes mediated the specific binding of hybrid exosomes toward melanoma tissues. The cytolytic molecules, such as granzyme A, granzyme B, perforin, and granulysin from γδ-T exosomes, induced specific apoptosis of cancer cells without harming normal cells. In response to light irradiation, ROS generation inside melanoma cells synergized with cytolytic molecules to induce apoptosis and promote immunogenic cancer cell death (ICD). The subsequently released damage-associated molecular patterns (DAMPs) could stimulate human dendritic cell maturation and induce melanoma antigen-specific CD4+ and CD8+ T-cell responses, thereby enhancing antitumor immunity. This study provides a promising strategy by combining γδ-T exosomes and PDT for photoimmunotherapy, thereby expanding the clinical applications of γδ-T exosome therapy for cancer patients.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"49 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143031235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hierarchical Nanocellulose Photonic Design for Synergistic Colored Radiative Cooling

IF 17.1 1区材料科学

ACS Nano Pub Date : 2025-01-25 DOI: 10.1021/acsnano.5c00330

Yi Zhou, Canhui Lu, Rui Xiong

{"title":"Hierarchical Nanocellulose Photonic Design for Synergistic Colored Radiative Cooling","authors":"Yi Zhou, Canhui Lu, Rui Xiong","doi":"10.1021/acsnano.5c00330","DOIUrl":"https://doi.org/10.1021/acsnano.5c00330","url":null,"abstract":"Daytime radiative cooling (DRC) materials offer a sustainable, pollution-free passive cooling solution. Traditional DRC materials are usually white to maximize solar reflectance, but applications like textiles and buildings need more aesthetic options. Unfortunately, colorizing DRC materials often reduce cooling efficiency due to colorant sunlight absorption. Thus, this study reports a hierarchical photonic structure consisting of photoluminescent scatterer networks and a nanocellulose cholesteric structure. This design effectively addresses the trade-off between cooling efficiency and coloration, achieving enhanced cooling through synergistic all-day coloration. Sustainable nanocellulose with highly ordered cholesteric structures selectively reflects visible wavelengths, generating structural color and high mid-infrared (MIR) emission. The photoluminescent scatterer networks enhance reflectance and convert absorbed light into photoluminescent emission, further promoting cooling. This synergistic photonic interaction results in a significantly enhanced high reflectance of 92%, high MIR emissivity of >90%, stable and tunable structural color appearance, and hours-long afterglow photoluminescence. Consequently, a subambient cooling of up to 11.3 °C under sunlight is attainable, accompanied by the ability to produce programmable structural color and photoluminescent patterns for daytime and nighttime visibility. The enhanced cooling efficiency achieved through the synergistic interplay of four optical mechanisms from the UV to MIR region offers a promising design paradigm for other DRC materials.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"6 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143031237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to “Fermi Level Pinning at Electrical Metal Contacts of Monolayer Molybdenum Dichalcogenides”

IF 17.1 1区材料科学

ACS Nano Pub Date : 2025-01-25 DOI: 10.1021/acsnano.4c18850

Changsik Kim, Inyong Moon, Daeyeong Lee, Min Sup Choi, Faisal Ahmed, Seunggeol Nam, Yeonchoo Cho, Hyeon-Jin Shin, Seongjun Park, Won Jong Yoo

引用次数: 0

Coupling Bifunctional Scaffolds with Slow Photon Effect for Synergistically Enhanced Photoassisted Lithium–Sulfur Battery Properties

IF 17.1 1区材料科学

ACS Nano Pub Date : 2025-01-25 DOI: 10.1021/acsnano.4c16595

Ting Meng, Xiaohan Wang, Wenbo Zhao, Yong Gao, Zeyu Geng, Jipeng Chen, Fan Bu, Haifei Zhu, Junwei Li, Haifeng Zhang, Cao Guan

{"title":"Coupling Bifunctional Scaffolds with Slow Photon Effect for Synergistically Enhanced Photoassisted Lithium–Sulfur Battery Properties","authors":"Ting Meng, Xiaohan Wang, Wenbo Zhao, Yong Gao, Zeyu Geng, Jipeng Chen, Fan Bu, Haifei Zhu, Junwei Li, Haifeng Zhang, Cao Guan","doi":"10.1021/acsnano.4c16595","DOIUrl":"https://doi.org/10.1021/acsnano.4c16595","url":null,"abstract":"Photoassisted lithium–sulfur (Li–S) batteries offer a promising approach to enhance the catalytic transformation kinetics of polysulfide. However, the development is greatly hindered by inadequate photo absorption and severe photoexcited carriers recombination. Herein, a photonic crystal sulfide heterojunction structure is designed as a bifunctional electrode scaffold for photoassisted Li–S batteries. Inverse opal (IO) structures utilize a slow photon effect that originates from their adjustable photonic band gaps, giving them distinctive optical response characteristics. The incorporation of a SnS/ZnS heterojunction within these IO frameworks further broadens the light absorption spectrum and enhances the charge transfer process. This efficient IO hybrid bifunctional electrode not only enhances the adsorption and conversion of polysulfides at the cathode but also induces uniform Li nucleation at the anode. These contribute the full batteries to output a high reversible capability of 1072 mAh g–1 and maintain stable cycling for 50 cycles. Additionally, a specific capacity of 698.8 mAh g–1 is still obtained even under a sulfur loading of up to 4 mg cm–2. The present strategy on SnS/ZnS IO to enhance photoassisted Li–S battery properties can be extended to rationally construct other energy storage devices.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"114 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143031126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Shape-Directed Dynamic Assembly of Active Colloidal Metamachines

IF 17.1 1区材料科学

ACS Nano Pub Date : 2025-01-24 DOI: 10.1021/acsnano.4c15465

Yang Huang, Ling Yang, Sipeng Yang, Hao Chen, Celi Lou, Yunqing Tang, Xiankun Lin, Qiang He

{"title":"Shape-Directed Dynamic Assembly of Active Colloidal Metamachines","authors":"Yang Huang, Ling Yang, Sipeng Yang, Hao Chen, Celi Lou, Yunqing Tang, Xiankun Lin, Qiang He","doi":"10.1021/acsnano.4c15465","DOIUrl":"https://doi.org/10.1021/acsnano.4c15465","url":null,"abstract":"Modularly organizing active micromachines into high-grade metamachines makes a great leap for operating the microscopic world in a biomimetic way. However, modulating the nonreciprocal interactions among different colloidal motors through chemical reactions to achieve the controllable construction of active colloidal metamachines with specific dynamic properties remains challenging. Here, we report the phototactic active colloidal metamachines constructed by shape-directed dynamic self-assembly of chemically driven peanut-shaped TiO2 colloidal motors and Janus spherical Pt/SiO2 colloidal motors. The long-range diffusiophoretic attraction generated by the photocatalytic reaction dominates the sensing and collision of peanut TiO2 motors with Janus Pt/SiO2 motors. The coupling of local chemical concentration gradient fields between the two types of motors generates short-range site-selective interactions, promoting the shape-directed assembly toward active colloidal metamachines with well-defined spatial configurations. Metamachines, made of colloidal motors, exhibit configuration-dependent kinematics. The colloidal metamachines can be reversibly reconstructed by adjusting lighting conditions and can move phototactically along a predetermined path under the structured light field. Such chemically driven colloidal metamachines that integrate multiple active agents provide a significant avenue for fabricating active soft matter materials and intelligent robotic systems with advanced applications.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"15 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143026516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Defect Migration and Phase Transformations in Two-Dimensional Iron Chloride inside Bilayer Graphene

IF 17.1 1区材料科学

ACS Nano Pub Date : 2025-01-24 DOI: 10.1021/acsnano.4c16177

Qiunan Liu, Haiming Sun, Yung-Chang Lin, Mahdi Ghorbani-Asl, Silvan Kretschmer, Chi-Chun Cheng, Po-Wen Chiu, Hiroki Ago, Arkady V. Krasheninnikov, Kazu Suenaga

{"title":"Defect Migration and Phase Transformations in Two-Dimensional Iron Chloride inside Bilayer Graphene","authors":"Qiunan Liu, Haiming Sun, Yung-Chang Lin, Mahdi Ghorbani-Asl, Silvan Kretschmer, Chi-Chun Cheng, Po-Wen Chiu, Hiroki Ago, Arkady V. Krasheninnikov, Kazu Suenaga","doi":"10.1021/acsnano.4c16177","DOIUrl":"https://doi.org/10.1021/acsnano.4c16177","url":null,"abstract":"The intercalation of metal chlorides, and particularly iron chlorides, into graphitic carbon structures has recently received lots of attention, as it can not only protect this two-dimensional (2D) magnetic system from the effects of the environment but also substantially alter the magnetic, electronic, and optical properties of both the intercalant and host material. At the same time, intercalation can result in the formation of structural defects or defects can appear under external stimuli, which can affect materials performance. These aspects have received so far little attention in dedicated experiments. In this study, we investigate the behavior of atomic-scale defects in iron chlorides intercalated into bilayer graphene by using scanning transmission electron microscopy and first-principles calculations. We observe transformations between the FeCl2 and FeCl3 phases and elucidate the role of defects in the transformations. Specifically, three types of defects are identified: Fe vacancies in FeCl2 domains and Fe adatoms and interstitials in FeCl3 domains, each exhibiting distinct dynamic behaviors. We also observed a crystalline phase with an unusual stoichiometry of Fe5Cl18 that has not been reported before. Our findings not only advance the understanding of intercalation mechanism of 2D materials but also highlight the profound impact of atomic-scale defects on their properties and potential technological applications.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"112 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143026517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Engineered Extracellular Vesicles Modified by Angiopep-2 Peptide Promote Targeted Repair of Spinal Cord Injury and Brain Inflammation

IF 17.1 1区材料科学

ACS Nano Pub Date : 2025-01-24 DOI: 10.1021/acsnano.4c14675

Guang Kong, Jie Liu, Juan Wang, Xiaohu Yu, Cong Li, Mingyang Deng, Minhao Liu, Siming Wang, Chunming Tang, Wu Xiong, Jin Fan

{"title":"Engineered Extracellular Vesicles Modified by Angiopep-2 Peptide Promote Targeted Repair of Spinal Cord Injury and Brain Inflammation","authors":"Guang Kong, Jie Liu, Juan Wang, Xiaohu Yu, Cong Li, Mingyang Deng, Minhao Liu, Siming Wang, Chunming Tang, Wu Xiong, Jin Fan","doi":"10.1021/acsnano.4c14675","DOIUrl":"https://doi.org/10.1021/acsnano.4c14675","url":null,"abstract":"Engineered extracellular vesicles play an increasingly important role in the treatment of spinal cord injury. In order to prepare more effective engineered extracellular vesicles, we biologically modified M2 microglia. Angiopep-2 (Ang2) is an oligopeptide that can target the blood–brain barrier. Through single-cell sequencing and immunofluorescence experiments, we confirmed that the expression of LRP-1, the targeted receptor of Ang2, was elevated after spinal cord injury. Subsequently, we integrated the Ang2 peptide segment into M2 microglia to obtain Ang2-EVs, which could successfully target the site of spinal cord injury. However, in order to improve the function of Ang2-EVs, we pretreated M2 microglia with melatonin, which has anti-inflammatory effects, to obtain M-Ang2-EVs. The results of single-nucleus sequencing of the mouse spinal cord verified that neurons and OPCs gradually transformed into subtypes related to nerve repair functions after treatment with M-Ang2-EVs. This is consistent with the sequencing and enrichment analysis of miRNAs contained in M-Ang2-EVs. We further verified through experiments that M-Ang2-EVs can promote microglia/macrophages to phagocytose sphingomyelin, promote axon remyelination and axon elongation, and maintain the integrity of the blood-spinal barrier. Since Ang2 can also target the blood–brain barrier, we found that M-Ang2-EVs can also reduce brain inflammation that results from spinal cord injury. Our study applied the Angiopep-2 peptide to spinal cord injury to enhance the targeting of injured cells, and successfully construct engineered extracellular vesicles that can target the spinal cord injury site and the brain.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"33 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143026515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correlative Raman–Voltage Microscopy Revealing the Localized Structure–Stress Relationship in Silicon Solar Cells

IF 17.1 1区材料科学

ACS Nano Pub Date : 2025-01-24 DOI: 10.1021/acsnano.4c13688

Tianyu Lan, Tianyi Zhao, Yan Liu, Jingyu Cao, Wenqi Li, Jie Yang, Xinyu Zhang, Yusheng Wang, Baoquan Sun

{"title":"Correlative Raman–Voltage Microscopy Revealing the Localized Structure–Stress Relationship in Silicon Solar Cells","authors":"Tianyu Lan, Tianyi Zhao, Yan Liu, Jingyu Cao, Wenqi Li, Jie Yang, Xinyu Zhang, Yusheng Wang, Baoquan Sun","doi":"10.1021/acsnano.4c13688","DOIUrl":"https://doi.org/10.1021/acsnano.4c13688","url":null,"abstract":"Knowledge of localized strain at the micrometer scale is essential for tailoring the electrical and mechanical properties of ongoing thinning of crystal silicon (c-Si) solar cells. Thinning c-Si wafers below 110 μm are susceptible to cracking in manufacturing due to the nonuniform stress distribution at a micrometer region, necessitating a rigorous technique to reveal the localized stress distribution correlating with its device electrical output. In this context, a Raman microscopy integrated with a photovoltage mapping setup with high resolution to the submicrometer scale is developed to acquire correlative Raman–voltage of the localized physical properties at the microcracks on the rear side of c-Si solar cells. By integrating photoelectrical, mechanical, and theoretical simulations, we elucidated the evolution of the microcracks. The localized stresses cause significant electrical output degradation in c-Si solar cells. In addition, theoretical simulations and experimental characterization indicate that the etched rear side acts as a more intense stress concentrator, resulting in an asymmetrical stress distribution between the rear and front sides of c-Si solar cells. This finding provides valuable insights into the origin of microcracks in c-Si solar cells and serves as a metrology tool for microscale mapping of strain-engineered photovoltaic modules.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"38 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143031238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis and Self-Assembly of Monodisperse Graphene Nanoribbons: Access to Submicron Architectures with Long-Range Order and Uniform Orientation

IF 17.1 1区材料科学

ACS Nano Pub Date : 2025-01-24 DOI: 10.1021/acsnano.4c12313

Jiangliang Yin, Hanfei Wang, Daniel Pyle, Shinyoung Choi, Yuzi Liu, Jianguo Wen, Jeffrey R. Guest, Joseph W. Lyding, Guangbin Dong

{"title":"Synthesis and Self-Assembly of Monodisperse Graphene Nanoribbons: Access to Submicron Architectures with Long-Range Order and Uniform Orientation","authors":"Jiangliang Yin, Hanfei Wang, Daniel Pyle, Shinyoung Choi, Yuzi Liu, Jianguo Wen, Jeffrey R. Guest, Joseph W. Lyding, Guangbin Dong","doi":"10.1021/acsnano.4c12313","DOIUrl":"https://doi.org/10.1021/acsnano.4c12313","url":null,"abstract":"Fabricating organic semiconducting materials into large-scale, well-organized architectures is critical for building high-performance molecular electronics. While graphene nanoribbons (GNRs) hold enormous promise for various device applications, their assembly into a well-structured monolayer or multilayer architecture poses a substantial challenge. Here, we report the preparation of length-defined monodisperse GNRs via the integrated iterative binomial synthesis (IIBS) strategy and their self-assembly into submicrometer architectures with long-range order, uniform orientation, as well as regular layers. The use of short alkyl side chains benefits forming stable multilayers through interlocking structures. By changing the length and backbone shapes of these monodisperse GNRs, various three-dimensional assemblies, including multilayer stripes, monolayer stripes, and nanowires, can be achieved, leading to different photophysical properties and band gaps. The discovery of these intriguing self-assembly behaviors of length-defined GNRs is expected to enable various future applications.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"62 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143026508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A CRISPR-Cas and Argonaute-Driven Two-Factor Authentication Strategy for Information Security

IF 17.1 1区材料科学

ACS Nano Pub Date : 2025-01-24 DOI: 10.1021/acsnano.4c17560

Ruijie Fu, Jinjie Hou, Zexiang Wang, Chenggong Zhu, Yunlei Xianyu

引用次数: 0