ACS Nano最新文献

Cascade-Type Microglial Pyroptosis Inhibitors for Enhanced Treatment of Cerebral Ischemia-Reperfusion Injury

IF 17.1 1区材料科学

ACS Nano Pub Date : 2025-03-06 DOI: 10.1021/acsnano.5c01434

Zhifei Cheng, Wei Shao, Chaoqi Wei, Yaru Zhang, Ru Xiao, Shuai Zhang, Jingyi Zhang, Yunfei She, Chenglin Pan, Qi Liu, Qi Wang

{"title":"Cascade-Type Microglial Pyroptosis Inhibitors for Enhanced Treatment of Cerebral Ischemia-Reperfusion Injury","authors":"Zhifei Cheng, Wei Shao, Chaoqi Wei, Yaru Zhang, Ru Xiao, Shuai Zhang, Jingyi Zhang, Yunfei She, Chenglin Pan, Qi Liu, Qi Wang","doi":"10.1021/acsnano.5c01434","DOIUrl":"https://doi.org/10.1021/acsnano.5c01434","url":null,"abstract":"Neuroinflammation is a critical factor in the progression of cerebral ischemia-reperfusion injury (CIRI). Pyroptosis, which is an inflammatory form of programmed cell death, greatly amplifies neuroinflammatory processes. It does so by promoting the release of various inflammatory contents that intensify the overall inflammatory response within the central nervous system. Therefore, targeting pyroptosis represents a promising therapeutic strategy for the treatment of CIRI. Excessive generation of reactive oxygen species (ROS) by overactivated microglia is considered to serve as the signal molecule that triggers NLRP3 inflammasome-mediated pyroptosis. However, current pyroptosis inhibitors that solely focus on eliminating existing ROS or inhibiting the NLRP3 inflammasome are not optimal. Here, by coating nanothylakoids (NTs) coengineered with fibrin-binding peptide and MG1 peptide onto dihydrotanshinone I (DT)-loaded nanocarriers, we have developed a cascade-type pyroptosis inhibitor (MDN-MC) that comprehensively regulates the ROS/NLRP3/pyroptosis axis. The incorporation of catalase on the surface of MDN-MC, along with the release of DT, facilitated cascade inhibition of pyroptosis by scavenging existing ROS and suppressing the expression of NLRP3. In the rat model of transient middle cerebral artery occlusion, enhanced behavioral recovery and facilitated neuronal repair were achieved through cascade targeting of inflammatory microglia at the lesion site and implementation of interventions to inhibit pyroptosis, thereby demonstrating promising therapeutic effects. Overall, this work emphasizes the importance of cascade-regulated pyroptosis in reducing neuroinflammation, offering an important mechanistic understanding and possible therapeutic approaches for CIRI.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"53 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143561117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Breakdown of Magic Numbers in Spherical Confinement

IF 17.1 1区材料科学

ACS Nano Pub Date : 2025-03-06 DOI: 10.1021/acsnano.4c11099

Junwei Wang, Jonathan Martín-González, Lukas J. Römling, Silvan Englisch, Chrameh Fru Mbah, Praveen Bommineni, Erdmann Spiecker, Michael Engel, Nicolas Vogel

{"title":"Breakdown of Magic Numbers in Spherical Confinement","authors":"Junwei Wang, Jonathan Martín-González, Lukas J. Römling, Silvan Englisch, Chrameh Fru Mbah, Praveen Bommineni, Erdmann Spiecker, Michael Engel, Nicolas Vogel","doi":"10.1021/acsnano.4c11099","DOIUrl":"https://doi.org/10.1021/acsnano.4c11099","url":null,"abstract":"Magic numbers in finite particle systems correspond to specific system sizes that allow configurations with low free energy, often exhibiting closed surface shells to maximize the number of nearest neighbors. Since their discovery in atomic nuclei, magic numbers have been essential for understanding the number-structure–property relationships in finite clusters across different scales. However, as the system size increases, the significance of magic numbers diminishes, and the precise system size at which magic number phenomena disappear remains uncertain. In this study, we investigate colloidal clusters formed through confined self-assembly. Small magic number clusters display icosahedral symmetry with closed surface shells, corresponding to pronounced free energy minima. Our findings reveal that beyond a critical system size, closed surface shells disappear, and free energy minima become less pronounced. Instead, we observe a distinct type of colloidal cluster, termed a football cluster, which retains icosahedral symmetry but features lower-coordinated facets disconnected by terraces. A sphere packing model demonstrates that forming closed surface shells becomes impossible beyond a critical system size, explaining the breakdown of magic numbers in large confined systems.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"49 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143561202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vitamin A-Integrated Cinnamaldehyde Nanoemulsion: A Nanotherapeutic Approach To Counteract Liver Fibrosis via Gut–Liver Axis Modulation

IF 17.1 1区材料科学

ACS Nano Pub Date : 2025-03-06 DOI: 10.1021/acsnano.5c00136

Xia Niu, Ge Chang, Ning Xu, Rui Li, Bingyu Niu, Rui Mao, Shan Wang, Guiling Li, Jiandong Jiang, Lulu Wang

{"title":"Vitamin A-Integrated Cinnamaldehyde Nanoemulsion: A Nanotherapeutic Approach To Counteract Liver Fibrosis via Gut–Liver Axis Modulation","authors":"Xia Niu, Ge Chang, Ning Xu, Rui Li, Bingyu Niu, Rui Mao, Shan Wang, Guiling Li, Jiandong Jiang, Lulu Wang","doi":"10.1021/acsnano.5c00136","DOIUrl":"https://doi.org/10.1021/acsnano.5c00136","url":null,"abstract":"Liver fibrosis, a complex process resulting from most chronic liver diseases, remains devoid of effective treatments. An increasing body of evidence links liver fibrosis to the “gut–liver axis”, with disruptions in the gut microbiota–host balance emerging as a critical contributor to its progression. Cinnamaldehyde (Cin), a natural compound with antioxidant, anti-inflammatory, and anticytotoxic properties, has shown potential in counteracting hepatic stellate cell (HSC) activation. Additionally, Cin has been shown to promote probiotics in the intestine, thereby restoring a healthy microbial community. These characteristics position Cin as a promising candidate for liver fibrosis treatment through modulation of the gut–liver axis. In this study, a Vitamin A (Va)-formulated Cin Nanoemulsion (Va-Cin@NM) was developed to enhance the physicochemical stability of Cin while preserving intestinal homeostasis and facilitating targeted liver deposition. In bile duct ligation (BDL)-induced liver fibrosis in rats, Va-Cin@NM intervention significantly reduced bile duct-like structure proliferation and collagen deposition in the liver. These effects are likely attributed to the restoration of gut microbiota, increased short-chain fatty acid (SCFA) concentrations, and improved intestinal integrity. Moreover, Va-Cin@NM treatment suppressed harmful bacterial populations in the liver, thus mitigating immune injury and inflammatory cell recruitment. Consequently, oxidative stress and HSC activation were attenuated. Overall, Va-Cin@NM demonstrates significant potential as a nanotherapeutic approach for liver fibrosis by modulating the gut–liver axis.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"212 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143561085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthetic Band Structure Engineering of Graphene Using Block Copolymer-Templated Dielectric Superlattices

IF 17.1 1区材料科学

ACS Nano Pub Date : 2025-03-06 DOI: 10.1021/acsnano.4c14500

Moeid Jamalzadeh, Zihan Zhang, Zhujun Huang, Miguel Manzo-Perez, Kim Kisslinger, Takashi Taniguchi, Kenji Watanabe, Pilkyung Moon, Gregory S. Doerk, Davood Shahrjerdi

{"title":"Synthetic Band Structure Engineering of Graphene Using Block Copolymer-Templated Dielectric Superlattices","authors":"Moeid Jamalzadeh, Zihan Zhang, Zhujun Huang, Miguel Manzo-Perez, Kim Kisslinger, Takashi Taniguchi, Kenji Watanabe, Pilkyung Moon, Gregory S. Doerk, Davood Shahrjerdi","doi":"10.1021/acsnano.4c14500","DOIUrl":"https://doi.org/10.1021/acsnano.4c14500","url":null,"abstract":"Engineering the electronic band structure of two-dimensional (2D) materials by imposing spatially periodic superlattice (SL) potentials opens a pathway to unconventional electronics. Nanopatterning the gate electrode or surface dielectric near 2D crystals provides a powerful strategy for realizing electrostatically tunable “remote” SLs with flexibility in lattice design. Here, we demonstrate the effectiveness of block copolymer (BCP)-templated dielectric nanopatterns for fabricating etch-free high-grade metal oxide SLs. Alumina (AlOx) nanopatterns with hexagonal symmetry and a 38 nm SL wavelength are produced as a model material by directly converting a self-assembled BCP film via block-selective vapor phase infiltration. Despite micrometer-scale rotational disorder inherent to BCP self-assembly, electronic transport measurements of graphene reveal replica Dirac points at zero field and Hofstadter mini-gaps under finite magnetic fields. These results indicate the successful formation of remote SL potentials in graphene resulting from optimized AlOx nanopattern fabrication to achieve consistent lattice symmetry and periodicity at a macroscopic scale. The findings of this study, combined with the versatile, scalable, and cost-effective nature of BCP nanopatterning, highlight the potential of BCP-templated nanostructures for remote SL engineering in 2D crystals.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"47 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143561081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Carrier Multiplication and Photoexcited Many-Body States in Solution-Processed 2H-MoSe2

IF 17.1 1区材料科学

ACS Nano Pub Date : 2025-03-06 DOI: 10.1021/acsnano.4c18254

Goutam Ghosh, Tian Carey, Stevie Furxhiu, Sven Weerdenburg, Nisha Singh, Marco van der Laan, Susan E. Branchett, Sophie Jaspers, John W. Suijkerbuijk, Fedor Lipilin, Zdeněk Sofer, Jonathan N. Coleman, Peter Schall, Laurens D. A. Siebbeles

{"title":"Carrier Multiplication and Photoexcited Many-Body States in Solution-Processed 2H-MoSe2","authors":"Goutam Ghosh, Tian Carey, Stevie Furxhiu, Sven Weerdenburg, Nisha Singh, Marco van der Laan, Susan E. Branchett, Sophie Jaspers, John W. Suijkerbuijk, Fedor Lipilin, Zdeněk Sofer, Jonathan N. Coleman, Peter Schall, Laurens D. A. Siebbeles","doi":"10.1021/acsnano.4c18254","DOIUrl":"https://doi.org/10.1021/acsnano.4c18254","url":null,"abstract":"Carrier multiplication (CM), where a single high-energy photon generates multiple electron–hole pairs, offers a promising route to enhance the efficiency of solar cells and photodetectors.Transition metal dichalcogenides, such as 2H-MoTe2 and 2H-WSe2, exhibit efficient CM. Given the similar electronic band structure of 2H-MoSe2, it is expected to show comparable CM efficiency. In this study, we establish the occurrence and efficiency of CM in a solution-processed thin film of bulk-like 2H-MoSe2. We characterize the dynamics of excitons and free charge carriers by using ultrafast transient optical absorption and terahertz spectroscopy. At higher photon energy the efficiency is comparable to literature results for 2H-MoTe2 grown by chemical vapor deposition (CVD) or in bulk crystalline form. At higher photon energies the experimental CM efficiency is reproduced by theoretical modeling. We also observe CM for photon energies below the energetic threshold of twice the band gap, which is most probably due to subgap defect states. Transient optical absorption spectra of 2H-MoSe2 exhibit features of trions from which we infer that photoexcitation leads to free charge carriers. We find no signatures of excitons at the indirect band gap. From analysis of the frequency dependence of the terahertz conductivity we infer that scattering of charge carriers in our sample is less than for CVD grown or bulk crystalline 2H-MoTe2. Our findings make solution-processed 2H-MoSe2 an interesting material for exploitation of CM in photovoltaic devices.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"16 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143561082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Connectivity-Dependent Exciton–Phonon Coupling in Cesium Bismuth Halide Quantum Dots

IF 17.1 1区材料科学

ACS Nano Pub Date : 2025-03-06 DOI: 10.1021/acsnano.4c18414

Beiye C. Li, Hugh Cairney, Yu Jin, Jinsoo Park, Siddhartha Sohoni, Lawson T. Lloyd, Yuzi Liu, Justin E. Jureller, Young Jay Ryu, Stella Chariton, Vitali B. Prakapenka, Richard D. Schaller, Giulia Galli, Gregory S. Engel

{"title":"Connectivity-Dependent Exciton–Phonon Coupling in Cesium Bismuth Halide Quantum Dots","authors":"Beiye C. Li, Hugh Cairney, Yu Jin, Jinsoo Park, Siddhartha Sohoni, Lawson T. Lloyd, Yuzi Liu, Justin E. Jureller, Young Jay Ryu, Stella Chariton, Vitali B. Prakapenka, Richard D. Schaller, Giulia Galli, Gregory S. Engel","doi":"10.1021/acsnano.4c18414","DOIUrl":"https://doi.org/10.1021/acsnano.4c18414","url":null,"abstract":"Metal halide octahedra form the fundamental functional building blocks of metal halide perovskites, dictating their structures, optical properties, electronic structures, and dynamics. In this study, we show that the connectivity of bismuth halide octahedra in Cs3Bi2Br9 and Cs3Bi2I9 quantum dots (QDs) changes with different halide elements. We use first-principles calculations to reveal the key role of the connectivity of bismuth halide octahedra on the wave function symmetry, Huang–Rhys factor, and exciton–phonon interaction strength. Following QD synthesis via a ligand-mediated transport method, the effect of connectivity is verified with transient absorption spectroscopy, where we contrast Cs3Bi2Br9 and Cs3Bi2I9 QD exciton dynamics. In photoexcited Cs3Bi2I9 QDs, phonons related to the vibrational motions of face-sharing [BiI6]3– bioctahedra couple strongly to the electronic state and drive rapid carrier relaxation. Equivalent signals are not observed for photoexcited Cs3Bi2Br9 QDs, implying a lack of phonon involvement in band-edge absorption and subsequent exciton relaxation. Our findings suggest that structural engineering can effectively tune the exciton–phonon coupling and therefore influence exciton relaxation and recombination in perovskite nanomaterials.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"8 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143561203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Coordination Chemistry Regulation Suppressing Voltage Hysteresis for Na3MnTi(PO4)3 in High-Rate Sodium-Ion Batteries

IF 17.1 1区材料科学

ACS Nano Pub Date : 2025-03-06 DOI: 10.1021/acsnano.4c18519

Shengping Deng, Chongran Song, Shuoshuo Cheng, Shiyu Li, Zhenxiang Cheng, Ying Bai

{"title":"Coordination Chemistry Regulation Suppressing Voltage Hysteresis for Na3MnTi(PO4)3 in High-Rate Sodium-Ion Batteries","authors":"Shengping Deng, Chongran Song, Shuoshuo Cheng, Shiyu Li, Zhenxiang Cheng, Ying Bai","doi":"10.1021/acsnano.4c18519","DOIUrl":"https://doi.org/10.1021/acsnano.4c18519","url":null,"abstract":"As a natrium superionic conductor, NASICON-type Na3MnTi(PO4)3 (NMTP) has garnered increasing attention for large-scale sodium-ion batteries due to its high stability and power densities. Nevertheless, it still suffers from an inferior rate capability and poor cycling longevity, arising from sluggish intrinsic kinetics and severe structural degradation. Herein, vanadium (V) is used as a dopant for equal substitution of manganese (Mn) and titanium (Ti) in NMTP to alleviate voltage hysteresis and enhance the cycling performance. V-doping regulates the local coordination chemistry of transition metals and reduces derivative antisite defect concentration upon cycling. Through density functional theory analysis, Na3Mn0.9V0.2Ti0.9(PO4)3 (NMTP-V0.2) demonstrates a lower bandgap and higher electronic conductivity. Additionally, V-doping significantly lowers the diffusion barrier of Na2, leading to Na+ diffusivity that is approximately two orders of magnitude higher than that of NMTP during the Mn2+/Mn3+ redox process. The as-prepared NMTP-V0.2 delivers an excellent rate capability of 85.3 mAh g–1 under 50 C and satisfactory cycling retention of 81% with a high capacity over 1400 cycles. Thus, the assembled NMTP-V0.2/hard carbon sodium-ion full cell achieves a high energy density of 292.3 Wh kg–1 as well as outstanding capacity retention of 92% after 500 cycles under 10 C. This result not only provides an approach for suppressing voltage hysteresis in polyanion cathodes but also offers guidance for designing high-power SIBs.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"67 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143561083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Modulating the Structural Complexity of AuNCs Aggregates for Generation of Bright Luminescence

IF 17.1 1区材料科学

ACS Nano Pub Date : 2025-03-06 DOI: 10.1021/acsnano.5c01675

Yongjie Zhang, Dewang Niu, Liyuan Zhang, Ensheng Zhang, Jinglin Shen

{"title":"Modulating the Structural Complexity of AuNCs Aggregates for Generation of Bright Luminescence","authors":"Yongjie Zhang, Dewang Niu, Liyuan Zhang, Ensheng Zhang, Jinglin Shen","doi":"10.1021/acsnano.5c01675","DOIUrl":"https://doi.org/10.1021/acsnano.5c01675","url":null,"abstract":"Self-assembly of coinage metal nanoclusters constitutes an important branch for the construction of bright luminescent materials. They also serve as a class of promising building blocks for the study of hierarchically organized assemblies due to their potential of generating high structural complexity. However, the strong intercluster interactions exert great difficulty and uncertainty on the modulation of the outcome aggregation structures. To explore a feasible methodology for constructing complex structures that combine order and disorder, accompanied by emerging desirable optical performances, herein we manipulate the supramolecular interactions of a gold nanocluster, namely, DPT-AuNCs through the incorporation of an amphiphilic cation, i.e., 1-dodecyl-3-methylimidazolium (DMI+). Diverse aggregation structures are obtained through coassembly, and a sea urchin-like aggregate with a complexity index of CI = 16.5 is formed by elevating the concentration of DMI+. Moreover, a positive correlation between structural complexity and emission intensity was observed, and strongly luminescent NCs-based aggregates were obtained. The mechanism for the emergence of structural complexity is demonstrated via kinetic studies, 1H NMR titration, theoretical computation, etc. The cation-π interaction is found to be vital for the association between DMI+ and DPT-AuNCs, which modulates the supramolecular interactions for assembly and in turn facilitates the growth of aggregates in multiple dimensions. The sea urchin-like aggregate is formed through a dynamic assembly process, mediated by the pre-equilibrium of DMI+ micelles at high concentrations. Finally, the luminescent NC aggregates can also be obtained by incorporating different types of amphiphilic cations, thus generalizing the method for constructing complex assembly structures.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"34 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143561118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Probiotic Delivery for Editing of the Gut Microbiota to Mitigate Colitis and Maintain Hepatic Homeostasis Via Gut–Liver Axis

IF 17.1 1区材料科学

ACS Nano Pub Date : 2025-03-06 DOI: 10.1021/acsnano.5c00325

Junwei Deng, Yaoyu Hu, Pengfei Zhu, Yi Yu, Qian Chen, Haitao Wu, Zhengbao Zha, Hua Wang, Yan Ma

{"title":"Probiotic Delivery for Editing of the Gut Microbiota to Mitigate Colitis and Maintain Hepatic Homeostasis Via Gut–Liver Axis","authors":"Junwei Deng, Yaoyu Hu, Pengfei Zhu, Yi Yu, Qian Chen, Haitao Wu, Zhengbao Zha, Hua Wang, Yan Ma","doi":"10.1021/acsnano.5c00325","DOIUrl":"https://doi.org/10.1021/acsnano.5c00325","url":null,"abstract":"Inflammatory bowel disease (IBD) compromises the intestinal barrier and disrupts gut microbiota, impacting liver function via the gut–liver axis, which in turn influences the intestinal microbiota through lipid metabolites exacerbating IBD. This study introduced a probiotic-based treatment using Lactobacillus acidophilus encapsulated in tungsten ion-loaded mesoporous polydopamine (LA@WMPDA) to ameliorate colitis and balance enterohepatic homeostasis. After oral administration, the encapsulation could protect Lactobacillus acidophilus, scavenge reactive oxygen/nitrogen species, and the released tungsten ions would inhibit abnormal Enterobacteriaceae growth during colitis, consequently restoring the intestinal barrier and regulating the gut microbiota. Nontargeted metabolomics and transcriptomics analyses showed increased short-chain fatty acids and indole derivatives, and decreased hepatic lipid metabolism. Pathways associated with immune response, cell migration and death, and response to bacterium showed significant down-regulation in the colon and liver transcriptome analysis. Thus, this study provided a pioneered paradigm for IBD treatment and highlighted the regulation of liver-related metabolic functions via the gut–liver axis.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"2 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143561084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dynamic Lithium Transport Pathway via Crack Formation in Phase-Separating Battery Particles

IF 17.1 1区材料科学

ACS Nano Pub Date : 2025-03-05 DOI: 10.1021/acsnano.4c15960

Chihyun Nam, Bonho Koo, Juwon Kim, Jinkyu Chung, Jaejung Song, Danwon Lee, Sungjae Seo, Munsoo Song, Seyeon Shin, Namdong Kim, Markus Weigand, Jian Wang, Jongwoo Lim

{"title":"Dynamic Lithium Transport Pathway via Crack Formation in Phase-Separating Battery Particles","authors":"Chihyun Nam, Bonho Koo, Juwon Kim, Jinkyu Chung, Jaejung Song, Danwon Lee, Sungjae Seo, Munsoo Song, Seyeon Shin, Namdong Kim, Markus Weigand, Jian Wang, Jongwoo Lim","doi":"10.1021/acsnano.4c15960","DOIUrl":"https://doi.org/10.1021/acsnano.4c15960","url":null,"abstract":"Nanoscale cracks within battery particles are ubiquitously induced during battery cycling. Tracking the origin of nanocrack formation and its subsequent propagation remains challenging, although it is crucial for the cycle life and kinetics of batteries. Moreover, it is even more challenging to understand how such nanocracks influence lithium (de)insertion pathways and local strain fields within battery particles. In this study, we utilized operando scanning transmission X-ray microscopy on individual LiFePO4 (LFP) particles to visualize the relationship between lithium (de)insertion pathways and crack formation and propagation. We first demonstrate the generation mechanism of nanocracks occurs when the lithium insertion pathway at the edge of fresh LFP particles induces strong tensile stress in the middle of the particle. Then, we directly observe the nanocrack propagation mechanism, where the freshly exposed surface near the crack activates a fast lithium (de)insertion pathway, completely altering the internal stress fields near the nanocrack. Once the nanocrack transforms the dynamic lithium pathway and distribution, the delithiation process induces crack-opening tensile stress, while the lithiation process generates crack-closing compressive stress. 3D phase-field simulations support these observations, showing how dynamic lithium distribution shapes stress fields. Our findings reveal a recursive chemo-mechanical loop involving lithium (de)insertion pathways, internal stress fields, and crack development.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"91 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143561086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0