ACS Nano最新文献

筛选
英文 中文
Piezo-Nanowired Stem Cells: Ultrasound-Powered Neuronal Commitment for Rapid Neural Circuit Reconstruction after Traumatic Brain Injury. 压电纳米线干细胞:创伤性脑损伤后快速神经回路重建的超声驱动神经元承诺。
IF 17.1 1区 材料科学
ACS Nano Pub Date : 2025-10-20 DOI: 10.1021/acsnano.5c08752
Keyi Li,Wenhan Wang,Wenjun Ma,Yiwei Li,Jiahao Zhang,Ailing Yin,Liang Wang,Boyan Li,Qingtong Wang,Gang Li,Hong Liu,Jichuan Qiu
{"title":"Piezo-Nanowired Stem Cells: Ultrasound-Powered Neuronal Commitment for Rapid Neural Circuit Reconstruction after Traumatic Brain Injury.","authors":"Keyi Li,Wenhan Wang,Wenjun Ma,Yiwei Li,Jiahao Zhang,Ailing Yin,Liang Wang,Boyan Li,Qingtong Wang,Gang Li,Hong Liu,Jichuan Qiu","doi":"10.1021/acsnano.5c08752","DOIUrl":"https://doi.org/10.1021/acsnano.5c08752","url":null,"abstract":"The inherently constrained regenerative capacity of neuronal tissue poses a major obstacle to repairing traumatic brain injury. While neural stem cell transplantation holds promise, its efficacy is constrained by slow and inefficient neuronal differentiation. Here, we engineered piezo-nanowired stem cells by anchoring piezoelectric barium titanate nanowires to neural stem cell membranes, enabling ultrasound-powered piezoelectrical stimulation to drive neuronal differentiation. The high-aspect-ratio barium titanate nanowires stably localize on cell membranes, enabling targeted electrical stimulation to membrane-bound receptors under ultrasound. In vitro, this approach accelerated neuronal differentiation by 5 days, increasing the mature neuron ratio from 14.0% to 30.7%, and enhancing synaptic network complexity. In a traumatic brain injury rat model, barium titanate nanowires combined with ultrasound promoted rapid neural stem cells differentiation into functional neurons, restoring motor and cognitive functions and reconstructing neural networks at the injury site. By integrating wireless piezoelectric stimulation with neural stem cell transplantation, this work provides a promising approach for precise neuromodulation in neurological regeneration.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"1 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145319114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nucleation-Mediated Aluminum Deposition/Stripping for Long-Life Molten Salt Aluminum Batteries. 长寿命熔盐铝电池的成核介导铝沉积/剥离。
IF 17.1 1区 材料科学
ACS Nano Pub Date : 2025-10-20 DOI: 10.1021/acsnano.5c10579
Zhitong Xiao,Yongfeng Jia,Lujun Zhu,Chenxi Zheng,Wei Hao,Pengfei Zhang,Jiashen Meng,Mengxue He,Lei Ji,Jian Wang,Mohammadhosein Safari,Yakun Liu,Wei Wen,Quanquan Pang
{"title":"Nucleation-Mediated Aluminum Deposition/Stripping for Long-Life Molten Salt Aluminum Batteries.","authors":"Zhitong Xiao,Yongfeng Jia,Lujun Zhu,Chenxi Zheng,Wei Hao,Pengfei Zhang,Jiashen Meng,Mengxue He,Lei Ji,Jian Wang,Mohammadhosein Safari,Yakun Liu,Wei Wen,Quanquan Pang","doi":"10.1021/acsnano.5c10579","DOIUrl":"https://doi.org/10.1021/acsnano.5c10579","url":null,"abstract":"Molten salt aluminum batteries (MSABs) hold significant promise for grid-scale energy storage due to the low cost and high capacity of the aluminum anode. However, an aluminum dendrite stemming from nonuniform electrodeposition leads to safety and stability issues. Here, we describe a membrane electrode with predeposited aluminum metal featuring surface-mediated nucleation and growth behavior for operation in alkali chloroaluminate melt electrolytes. The introduction of TiN, as aluminophilic sites, facilitates the initial growth of aluminum on TiN by forming Al-N bonding, thereby enabling uniform aluminum nucleation and mediated growth along the TiN/C fiber, resulting in reversible and dendrite-free aluminum plating/stripping. The TiN/C@Al electrode enables symmetric cells to maintain stable cycling for over 850 h (10.0 mA cm-2; 5.0 mA h cm-2) and shows high rate performance at up to 30.0 mA cm-2. The Al-graphite cell using a TiN/C@Al anode demonstrates long-term stability over 7000 cycles at 2.0 A g-1 and enhanced rate capability with 72.2 mA h g-1 even at 5.0 A g-1. To validate practical scalability, we designed an Ah-level TiN/C@Al-based molten salt Al-graphite pouch cell. This approach offers a scalable pathway for overcoming the limitations of state-of-the-art anodes in MSABs, enabling high-performance and cost-effective energy storage solutions.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"25 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145319237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Production-Ready Double-Sided Fabrication of Dual-Band Infrared Metaoptics Using Deep-Ultraviolet Lithography 利用深紫外光刻技术制备双波段红外元光学器件
IF 17.1 1区 材料科学
ACS Nano Pub Date : 2025-10-19 DOI: 10.1021/acsnano.5c11908
Kai Sun, Xingzhao Yan, Jordan Scott, Jun-Yu Ou, James N. Monks, Otto L. Muskens
{"title":"Production-Ready Double-Sided Fabrication of Dual-Band Infrared Metaoptics Using Deep-Ultraviolet Lithography","authors":"Kai Sun, Xingzhao Yan, Jordan Scott, Jun-Yu Ou, James N. Monks, Otto L. Muskens","doi":"10.1021/acsnano.5c11908","DOIUrl":"https://doi.org/10.1021/acsnano.5c11908","url":null,"abstract":"Metaoptics, the application of metasurfaces into optical systems, is seeing an accelerating development owing to advantages in size, weight, and cost and the ability to program optical functions beyond traditional refractive optics. The transition of metaoptics from the laboratory into applications is enabled by scalable production methods based on highly reproducible semiconductor process technology. Here, we introduce a method for the fabrication of double-sided metasurfaces through deep-UV lithography as a production-ready method for achieving high-quality metaoptics. We achieve patterning of a silicon wafer on both sides with mutual alignment of around 10 μm based on tool accuracy without requiring through-wafer alignment markers other than the wafer notch. An application highlighting the benefits of double-sided design is demonstrated in the form of a dual-band metalens with independent control over focal lengths in mid- and long-wavelength infrared bands. Using multireticle stitching, we demonstrate a 40 mm diameter, large-area metalens with excellent broadband imaging performance, showing partial canceling of chromatic dispersion when used in a hybrid configuration with a BaF<sub>2</sub> refractive lens. Our work establishes a production-ready approach to infrared metaoptics designs and double-sided metaoptics fabrication with direct potential for translation into scalable technology for real-world applications.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"98 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145314662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chiral Two-Dimensional Cu-Pb Bromides: Circularly Polarized Luminescence and Pressure-Enhanced Optical Properties. 手性二维Cu-Pb溴化物:圆偏振发光和压力增强光学性质。
IF 17.1 1区 材料科学
ACS Nano Pub Date : 2025-10-19 DOI: 10.1021/acsnano.5c14764
Peiran Xie,Congcong Chen,Pan Wang,Jiawei Lin,Kejun Bu,Tonghuan Fu,Songhao Guo,Hengqian Zhang,Xiao-Wu Lei,Xujie Lü,Lingling Mao
{"title":"Chiral Two-Dimensional Cu-Pb Bromides: Circularly Polarized Luminescence and Pressure-Enhanced Optical Properties.","authors":"Peiran Xie,Congcong Chen,Pan Wang,Jiawei Lin,Kejun Bu,Tonghuan Fu,Songhao Guo,Hengqian Zhang,Xiao-Wu Lei,Xujie Lü,Lingling Mao","doi":"10.1021/acsnano.5c14764","DOIUrl":"https://doi.org/10.1021/acsnano.5c14764","url":null,"abstract":"The search for high-performance double perovskite-related materials remains constrained by the limited synthetic accessibility of bimetallic halides compared to their conventional halide double perovskite counterparts, leaving substantial unexplored territory in this domain. A promising structural modification strategy involves the incorporation of chiral organic moieties into the metal halide frameworks, enabling precise engineering of noncentrosymmetric structures toward targeted functional properties. Here, we report a pair of chiral two-dimensional (2D) Cu(I)-Pb bimetallic bromides (R/S-PCA)4Cu2PbBr8·H2O (R/S-CuPbBr, R/S-PCA = R/S-3-piperidinecarboxylic acid) and investigate their behavior under external stimuli including pressure and temperature. The R/S-CuPbBr compounds crystallize in a noncentrosymmetric monoclinic C2 space group, consisting of inorganic bimetal [Cu2PbBr8] layers and organic layers formed via hydrogen bonding interactions. For comparison, another pair of 2D Pb-based bromides (R/S-PCA)3Pb2Br7·H2O (R/S-PbBr) was synthesized, crystallizing in the noncentrosymmetric orthorhombic P212121. These materials exhibit broadband yellow emission and circularly polarized luminescence emission at room temperature. The glum values of R/S-CuPbBr and R/S-PbBr are 8.63 × 10-3 and -7.99 × 10-3, 4.33 × 10-3 and -3.52 × 10-3, respectively. Density functional theory (DFT) calculations reveal R/S-CuPbBr and R/S-PbBr are indirect and direct bandgap semiconductors, respectively. More importantly, R-CuPbBr exhibits dramatic enhancements in optical properties under high pressure, with an 8-fold increase in photoluminescence and 44-fold boost in second-harmonic generation at elevated pressure.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"78 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145319134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tuning Nanoparticle Rigidity: From Megadalton Dendritic Dots to Mechanobiology-Driven Nano-Bio Interactions. 调谐纳米粒子刚性:从兆道尔顿树突状点到机械生物学驱动的纳米生物相互作用。
IF 17.1 1区 材料科学
ACS Nano Pub Date : 2025-10-19 DOI: 10.1021/acsnano.5c12912
Yincong Zhu,Jianxiang Huang,Yuji Sun,Zichao He,Weiwei Feng,Huiming Ren,Yongzhao Su,Zhehao Wang,Ying Piao,Youqing Shen,Zhuxian Zhou
{"title":"Tuning Nanoparticle Rigidity: From Megadalton Dendritic Dots to Mechanobiology-Driven Nano-Bio Interactions.","authors":"Yincong Zhu,Jianxiang Huang,Yuji Sun,Zichao He,Weiwei Feng,Huiming Ren,Yongzhao Su,Zhehao Wang,Ying Piao,Youqing Shen,Zhuxian Zhou","doi":"10.1021/acsnano.5c12912","DOIUrl":"https://doi.org/10.1021/acsnano.5c12912","url":null,"abstract":"Nanoparticle rigidity is a critical yet poorly understood regulator of nano-bio interactions, but decoupling rigidity from other properties (size, charge) remains challenging. Here, we synthesize ultrahigh-generation dye-cored polylysine dendritic dots (PDDs) with precisely tunable rigidity (Young's moduli: 0.93-1.90 GPa), enabling a systematic study of rigidity effects in megadalton dendrimers. These PDDs, produced at the gram scale with close size/charge but generation-dependent stiffness, reveal a striking mechanobiological trade-off: Stiffer PDDs exhibit enhanced cellular uptake, transcytosis, and deep penetration in three-dimensional (3D) tumor spheroids, while softer ones show prolonged blood circulation and superior tumor accumulation. This work deciphers rigidity's dual role in nano-bio interactions, presenting PDDs as a versatile model for mechanobiology studies and providing actionable design principles for next-generation drug delivery systems.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"131 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145319133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Optimized Synthesis and Device Integration of Long 17-Atom-Wide Armchair Graphene Nanoribbons 17原子宽扶手型长石墨烯纳米带的优化合成与器件集成
IF 17.1 1区 材料科学
ACS Nano Pub Date : 2025-10-17 DOI: 10.1021/acsnano.5c11981
Jeong Ha Hwang, Nicolò Bassi, Mayada Fadel, Oliver Braun, Tim Dumslaff, Carlo A. Pignedoli, Michael Stiefel, Roman Furrer, Hironobu Hayashi, Hiroko Yamada, Akimitsu Narita, Klaus Müllen, Michel Calame, Mickael Perrin, Roman Fasel, Pascal Ruffieux, Vincent Meunier, Gabriela Borin Barin
{"title":"Optimized Synthesis and Device Integration of Long 17-Atom-Wide Armchair Graphene Nanoribbons","authors":"Jeong Ha Hwang, Nicolò Bassi, Mayada Fadel, Oliver Braun, Tim Dumslaff, Carlo A. Pignedoli, Michael Stiefel, Roman Furrer, Hironobu Hayashi, Hiroko Yamada, Akimitsu Narita, Klaus Müllen, Michel Calame, Mickael Perrin, Roman Fasel, Pascal Ruffieux, Vincent Meunier, Gabriela Borin Barin","doi":"10.1021/acsnano.5c11981","DOIUrl":"https://doi.org/10.1021/acsnano.5c11981","url":null,"abstract":"Seventeen-carbon-atom-wide armchair graphene nanoribbons (17-AGNRs) are promising candidates for high-performance electronic devices due to their narrow electronic bandgap. Atomic precision in edge structure and width control is achieved through a bottom-up on-surface synthesis (OSS) approach from tailored molecular precursors in ultrahigh vacuum (UHV). This synthetic protocol must be optimized to meet the structural requirements for device integration, with the ribbon length being the most critical parameter. Here, we report optimized OSS conditions that produce 17-AGNRs with an average length of ∼17 nm. This length enhancement is achieved through a gradual temperature ramping during an extended annealing period, combined with a template-like effect driven by monomer assembly at high surface coverage. The resulting 17-AGNRs are comprehensively characterized in UHV by using scanning probe techniques and Raman spectroscopy. Raman measurements following substrate transfer enabled the characterization of GNRs’ length distribution on the device substrate and confirmed their stability under ambient conditions and harsh chemical environments, including acid vapors and etchants. The increased length and ambient stability of the 17-AGNRs led to their reliable integration into device architectures. As a proof of concept, we integrate 17-AGNRs into field-effect transistors (FETs) with graphene electrodes and confirm that electronic transport occurs through the GNRs. This work demonstrates the feasibility of integrating narrow bandgap GNRs into functional devices and contributes to advancing the development of carbon-based nanoelectronics.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"20 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145306317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dual-Action Cellular Nanoparticles for Effective Lead (Pb2+) Detoxification 双作用细胞纳米颗粒有效的铅(Pb2+)解毒
IF 17.1 1区 材料科学
ACS Nano Pub Date : 2025-10-17 DOI: 10.1021/acsnano.5c11268
Wei-Ting Shen, Jiayuan Alex Zhang, Yiyan Yu, Sydney D. Zhang, Lei Sun, Mingxuan Kai, Weiwei Gao, Liangfang Zhang
{"title":"Dual-Action Cellular Nanoparticles for Effective Lead (Pb2+) Detoxification","authors":"Wei-Ting Shen, Jiayuan Alex Zhang, Yiyan Yu, Sydney D. Zhang, Lei Sun, Mingxuan Kai, Weiwei Gao, Liangfang Zhang","doi":"10.1021/acsnano.5c11268","DOIUrl":"https://doi.org/10.1021/acsnano.5c11268","url":null,"abstract":"Lead (Pb<sup>2+</sup>) exposure remains a persistent and serious public health concern due to its widespread presence and profound toxicity. Building on recent advances in toxin-neutralizing cell membrane-coated nanoparticles (CNPs) and the discovery of Pb<sup>2+</sup>-binding DNA aptamers, we develop dual-action neuron-mimetic CNPs for effective Pb<sup>2+</sup> detoxification. In the formulation, the CNPs encapsulate aptamers within metal–organic framework (MOF) cores and coated with membranes derived from SH-SY5Y neuroblastoma cells, two functional components working together to neutralize Pb<sup>2+</sup>. The resulting constructs, termed Neuron-MOF/aptamer-NPs, exhibit strong Pb<sup>2+</sup> binding capacity, excellent colloidal stability in physiological media, and resistance to DNA leakage. <i>In vitro</i> assays identify Neuron-MOF/aptamer-NPs as the most potent formulation, demonstrating dual-action neutralization against Pb<sup>2+</sup>-induced toxicity, oxidative stress, and lipid peroxidation in SH-SY5Y cells. <i>In vivo</i>, Neuron-MOF/aptamer-NP treatment significantly improves survival in a mouse model of lead poisoning and reduces hematologic, hepatic, and renal damage. Behavioral assessments further confirm the restoration of spatial memory and locomotor function. Neuron-MOF/aptamer-NPs exhibit no signs of acute toxicity in healthy mice. These findings establish Neuron-MOF/aptamer-NPs as a potent and biocompatible therapeutic platform for targeted lead detoxification with systemic and neuroprotective benefits.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"58 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145311662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Artificial Intelligence-Assisted Low-Dose High Atomic Number Contrast Agent for Ultrahigh-Resolution Computed Tomography Angiography 用于超高分辨率计算机断层血管造影的人工智能辅助低剂量高原子序数造影剂
IF 17.1 1区 材料科学
ACS Nano Pub Date : 2025-10-17 DOI: 10.1021/acsnano.5c12047
Shujie Li, Houde Wu, Li Guo, Xiaoyi Wang, Gang Shu, Xinxing Li, Shao-Kai Sun
{"title":"Artificial Intelligence-Assisted Low-Dose High Atomic Number Contrast Agent for Ultrahigh-Resolution Computed Tomography Angiography","authors":"Shujie Li, Houde Wu, Li Guo, Xiaoyi Wang, Gang Shu, Xinxing Li, Shao-Kai Sun","doi":"10.1021/acsnano.5c12047","DOIUrl":"https://doi.org/10.1021/acsnano.5c12047","url":null,"abstract":"Achieving high resolution while minimizing contrast agent dosage remains a key goal, yet a major challenge in contrast-enhanced computed tomography (CT) imaging. Herein, we propose an artificial intelligence-assisted low-dose high atomic number contrast agent for ultrahigh-resolution CT imaging. As a proof of concept, high-quality PEGylated hafnium oxide nanoparticles (DA-HfO<sub>2</sub> NPs) are synthesized, exhibiting superior X-ray attenuation, high hafnium content (36%), excellent water solubility, appropriate hydrodynamic size (13.5 nm), and prolonged circulation half-life (161.9 min). High-dose DA-HfO<sub>2</sub> NPs enable extended ultrahigh-resolution vascular imaging with a spatial resolution of 0.15 mm and a time window of at least 60 min. More importantly, by integrating artificial intelligence, the low-dose contrast agent (at 25% of the standard dose) achieves imaging quality comparable to that of the high-dose agent in both contrast density and spatial resolution, while simultaneously enhancing biosafety. This strategy enables high-resolution imaging at reduced contrast agent doses and offers a promising approach for sensitive and safe CT angiography.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"101 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145311663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
RNA Binding Sensitivity of Nonstructural Protein 8 Revealed by Small-Angle Neutron Scattering and Alphafold2 Prediction. 小角中子散射和Alphafold2预测揭示非结构蛋白8的RNA结合敏感性。
IF 17.1 1区 材料科学
ACS Nano Pub Date : 2025-10-17 DOI: 10.1021/acsnano.4c16790
Xin Jiang,Jinxin Xu,Zhenyu Liao,Na Wang,Taisen Zuo,Changli Ma,Hanqiu Jiang,Yubin Ke,He Cheng,Howard Wang,Jinkui Zhao,Jun Fan,Jinsong Liu,Xiangqiang Chu
{"title":"RNA Binding Sensitivity of Nonstructural Protein 8 Revealed by Small-Angle Neutron Scattering and Alphafold2 Prediction.","authors":"Xin Jiang,Jinxin Xu,Zhenyu Liao,Na Wang,Taisen Zuo,Changli Ma,Hanqiu Jiang,Yubin Ke,He Cheng,Howard Wang,Jinkui Zhao,Jun Fan,Jinsong Liu,Xiangqiang Chu","doi":"10.1021/acsnano.4c16790","DOIUrl":"https://doi.org/10.1021/acsnano.4c16790","url":null,"abstract":"The flexible structure enables nonstructural protein 8 (nsp8) to respond quickly to environmental changes, which are essential for RNA replication and transcription of SARS-CoV-2. In this work, small-angle neutron scattering and AlphaFold2 prediction were applied to characterize the structural change of SARS-CoV-2 nsp8 dimers and tetramers. The results demonstrated that the nsp8 tetramer with a more exposed core domain shows a low thermal stability. The exposed core domain increases its sensitivity to RNA and adapts its structure to interact with RNA. Our work reveals the structural difference between the two forms of SARS-CoV-2 nsp8s in the RNA synthesis process, which partly elucidates the molecular mechanism behind RNA replication of the RNA virus.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"125 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145305549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Elucidating the Mechanisms of Ion Permeation through Sub-Nanometer Graphene Pores: Uncovering Free Energy Barriers via High-Throughput Molecular Simulations 亚纳米石墨烯孔离子渗透机制的研究:通过高通量分子模拟揭示自由能垒
IF 17.1 1区 材料科学
ACS Nano Pub Date : 2025-10-17 DOI: 10.1021/acsnano.5c13306
Andres F. Ordorica, Peifu Cheng, Pavan Chaturvedi, Peter T. Cummings, Piran R. Kidambi
{"title":"Elucidating the Mechanisms of Ion Permeation through Sub-Nanometer Graphene Pores: Uncovering Free Energy Barriers via High-Throughput Molecular Simulations","authors":"Andres F. Ordorica, Peifu Cheng, Pavan Chaturvedi, Peter T. Cummings, Piran R. Kidambi","doi":"10.1021/acsnano.5c13306","DOIUrl":"https://doi.org/10.1021/acsnano.5c13306","url":null,"abstract":"Understanding ion transport through subnanometer graphene nanopores is critical for advancing nanoscale filtration technologies and uncovering the molecular mechanisms underlying selective ion permeation. Owing to their atomic thickness and tunable pore sizes, nanoporous graphene membranes serve as a model system for probing ion selectivity and hydration behavior under spatial confinement. This work investigates the transport of Na<sup>+</sup>, Cl<sup>–</sup>, K<sup>+</sup>, and water through graphene nanopores to elucidate their ion-sieving characteristics. Free energy barriers associated with ion and water permeation are quantified, offering insight into the energetic costs of dehydration and translocation through nanopores. Selective ion transport is further examined using the constant potential method (CPM), which more accurately reflects experimental electrochemical conditions, and allows for the selective permeation of K<sup>+</sup> over Na<sup>+</sup> within nanoporous graphene membranes. The role of externally applied electric fields is also explored to assess their impact on ion hydration and transport dynamics. Together, these results contribute to a deeper mechanistic understanding of ion confinement, hydration, and selective permeation in nanoporous atomically thin membranes.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"101 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145311697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信