ACS Nano最新文献

{"title":"Second-Order Conductivity Probes a Cascade of Singularities in a Moiré Superlattice","authors":"Tanweer Ahmed, Bao Q. Tu, Kenji Watanabe, Takashi Taniguchi, Marco Gobbi, Fèlix Casanova, Luis E. Hueso","doi":"10.1021/acsnano.5c03684","DOIUrl":"https://doi.org/10.1021/acsnano.5c03684","url":null,"abstract":"Systems lacking inversion symmetry inherently demonstrate a nonlinear electrical response (NLER) to an applied electric bias, emerging through extrinsic mechanisms. This response is highly sensitive to the electronic band structure, which can be precisely engineered in moiré superlattices formed from atomically thin quantum materials. Moiré superlattices host complex Fermi surface reconstructions near van Hove singularities (vHSs) in the electronic density of states. However, the role of these reconstructions in shaping the NLER remains insufficiently understood. In this work, we systematically explore NLER in moiré superlattices of twisted double bilayer graphene (tDBLG) by tuning the Fermi level across multiple moiré bands on both sides of the charge neutrality point. We observe sharp variations and sign reversals in the NLER appearing via extrinsic pathways near midband vHSs. The second-order conductivity near the vHSs demonstrates a value as high as ∼70 μm V^–1 Ω^–1 at zero vertical displacement field. Our results demonstrate that the NLER can serve as a sensitive probe of Fermi surface reconstructions and establish tDBLG as a versatile and highly efficient platform for generating and controlling the nonlinear electrical response.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"16 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144516172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DNA-Mediated Bioinspired MXene Gas Sensor Array with Machine Learning for Noninvasive Cancer Recognition","authors":"Shanshan Liu, Nanlin Hu, Jiawang Hu, Wenting Li, Shikai Wu, Xiaoyan Ma, Yi-Xin Huo, Yuan Lu","doi":"10.1021/acsnano.5c06893","DOIUrl":"https://doi.org/10.1021/acsnano.5c06893","url":null,"abstract":"Noninvasive odor sensing is important in environmental monitoring and medical diagnosis. The two-dimensional material MXene is widely used due to its unique sensing properties but has limitations in specifically recognizing a certain gas. This study developed a bioinspired biosensor array (BBA) whose core mechanism involved programming MXene sensing interfaces through DNA base sequences to mimic molecular recognition principles of biological olfactory receptors. Integrated with machine learning algorithms, the BBA achieved preliminary identification of cancer patients by detecting exhaled gas samples from different populations. Starting from DNA molecular length, base type, and chemical modification, different DNAs were prepared and screened by orthogonal experiments to obtain five DNA/MXene composite biosensing materials with excellent sensing properties. Combined with pure MXene, a Six-channel bioinspired biosensor Array(6C-BBA) was established, and a neural network algorithm was utilized for the preliminary validation of the real odor molecules of fruits. Finally, the high-performance 6C-BBA was used to detect breath samples from stomach cancer patients, lung cancer patients, intestinal cancer patients, and healthy people, and the array showed 86.3, 94.1, 89.5, and 86.3% accuracy. This study could offer a specific method for advanced biosensor development and reveal important applications in early noninvasive recognition of diseases.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"1 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144516174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Homotransplantation of Engineered Macrophages with Surface-Modified Nanomedicines for Mitigating Myocardial Ischemia-Reperfusion Injury.","authors":"Jiahui Cheng, Rifeng Gao, Yang Lyu, Zhi Xiong, Kun Yang, Xinxin Zhao, Xiaoyu Huang, Lingling Xu, Linghuan Guo, Wen Wang, Yuzhuo Li, Weina Ding, Peng Guo, Zhiqiang Ji, Wenli Li, Xu Han, Jin Zhang, Shiteng Suo, Huilin Zhao, Lixian Jiang, Qiang Zhang, Bo Li, Lianming Wu, Yan Zhou","doi":"10.1021/acsnano.5c05068","DOIUrl":"https://doi.org/10.1021/acsnano.5c05068","url":null,"abstract":"<p><p>Immune disorders are intimately involved in the pathological progression of myocardial ischemia-reperfusion injury (MIRI) and exacerbate cardiac cell damage and mitochondria-related metabolic abnormalities. However, low-immunogenic therapeutic strategies targeting the compromised immune-metabolic microenvironment remain a major challenge. Here, we developed a syngenic reparative macrophage system for the selective delivery of nanoscale drugs by modifying liposomes loaded with nano-Pt/Se and c176 onto the surface of M2 macrophages (PS-c@M). In MIRI mice, transplanted PS-c@M was actively recruited to the myocardial ischemic region, maintained long-lasting residence, and responsively released surface-loaded nanomedicines, which in turn synergistically promoted cardiac cell survival and activated extracellular repair and angiogenesis, thus exerting long-term cardioprotective effects. Specifically, PS-c@M significantly inhibited STING-related signaling pathways, thereby remodeling the immune-inflammatory homeostasis, as evidenced by the increased proportions of M2 macrophages, reparative cardiac resident macrophages, and regulatory T cells and the decreased recruitment and infiltration of M1 macrophages and neutrophils. Moreover, PS-c@M facilitated mitochondrial oxidative phosphorylation and suppressed mitochondria-associated ferroptosis and oxidative damage. This study highlights a low-immunogenic targeted therapeutic strategy based on syngenic reparative macrophages as efficient nanomedicine carriers, with potential for development and application in a wide range of immune and inflammation-related diseases.</p>","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":" ","pages":""},"PeriodicalIF":15.8,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144511250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Technology Roadmap of Micro/Nanorobots.","authors":"Xiaohui Ju, Chuanrui Chen, Cagatay M Oral, Semih Sevim, Ramin Golestanian, Mengmeng Sun, Negin Bouzari, Xiankun Lin, Mario Urso, Jong Seok Nam, Yujang Cho, Xia Peng, Fabian C Landers, Shihao Yang, Azin Adibi, Nahid Taz, Raphael Wittkowski, Daniel Ahmed, Wei Wang, Veronika Magdanz, Mariana Medina-Sánchez, Maria Guix, Naimat Bari, Bahareh Behkam, Raymond Kapral, Yaxin Huang, Jinyao Tang, Ben Wang, Konstantin Morozov, Alexander Leshansky, Sarmad Ahmad Abbasi, Hongsoo Choi, Subhadip Ghosh, Bárbara Borges Fernandes, Giuseppe Battaglia, Peer Fischer, Ambarish Ghosh, Beatriz Jurado Sánchez, Alberto Escarpa, Quentin Martinet, Jérémie Palacci, Eric Lauga, Jeffrey Moran, Miguel A Ramos-Docampo, Brigitte Städler, Ramón Santiago Herrera Restrepo, Gilad Yossifon, James D Nicholas, Jordi Ignés-Mullol, Josep Puigmartí-Luis, Yutong Liu, Lauren D Zarzar, C Wyatt Shields, Longqiu Li, Shanshan Li, Xing Ma, David H Gracias, Orlin Velev, Samuel Sánchez, Maria Jose Esplandiu, Juliane Simmchen, Antonio Lobosco, Sarthak Misra, Zhiguang Wu, Jinxing Li, Alexander Kuhn, Amir Nourhani, Tijana Maric, Ze Xiong, Amirreza Aghakhani, Yongfeng Mei, Yingfeng Tu, Fei Peng, Eric Diller, Mahmut Selman Sakar, Ayusman Sen, Junhui Law, Yu Sun, Abdon Pena-Francesch, Katherine Villa, Huaizhi Li, Donglei Emma Fan, Kang Liang, Tony Jun Huang, Xiang-Zhong Chen, Songsong Tang, Xueji Zhang, Jizhai Cui, Hong Wang, Wei Gao, Vineeth Kumar Bandari, Oliver G Schmidt, Xianghua Wu, Jianguo Guan, Metin Sitti, Bradley J Nelson, Salvador Pané, Li Zhang, Hamed Shahsavan, Qiang He, Il-Doo Kim, Joseph Wang, Martin Pumera","doi":"10.1021/acsnano.5c03911","DOIUrl":"https://doi.org/10.1021/acsnano.5c03911","url":null,"abstract":"<p><p>Inspired by Richard Feynman's 1959 lecture and the 1966 film <i>Fantastic Voyage</i>, the field of micro/nanorobots has evolved from science fiction to reality, with significant advancements in biomedical and environmental applications. Despite the rapid progress, the deployment of functional micro/nanorobots remains limited. This review of the technology roadmap identifies key challenges hindering their widespread use, focusing on propulsion mechanisms, fundamental theoretical aspects, collective behavior, material design, and embodied intelligence. We explore the current state of micro/nanorobot technology, with an emphasis on applications in biomedicine, environmental remediation, analytical sensing, and other industrial technological aspects. Additionally, we analyze issues related to scaling up production, commercialization, and regulatory frameworks that are crucial for transitioning from research to practical applications. We also emphasize the need for interdisciplinary collaboration to address both technical and nontechnical challenges, such as sustainability, ethics, and business considerations. Finally, we propose a roadmap for future research to accelerate the development of micro/nanorobots, positioning them as essential tools for addressing grand challenges and enhancing the quality of life.</p>","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":" ","pages":""},"PeriodicalIF":15.8,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144511254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intrinsic Wrinkling of Free-Standing Polycrystalline Atomically Thin Films.","authors":"Jaehyung Yu, Colin Scheibner, Ce Liang, Thomas A Witten, Vincenzo Vitelli, Jiwoong Park","doi":"10.1021/acsnano.5c02583","DOIUrl":"https://doi.org/10.1021/acsnano.5c02583","url":null,"abstract":"<p><p>Atomically thin films, like transition metal dichalcogenides, can now be synthesized at wafer scale while maintaining monolayer thickness. At such extreme aspect ratios, atomistic simulations and existing experimental techniques are unable to directly predict or measure the mechanical effects of intrinsic features like polycrystallinity without the interference of pinned boundaries or solid substrates. To address this challenge, here we introduce a versatile approach: we realize large scale free-floating membranes on water and measure their mechanical properties using atomic force microscopy (AFM) and Raman spectroscopy adapted to water's surface. We reveal that free-standing polycrystalline membranes spontaneously form large athermal wrinkles. These wrinkles differ from those of extrinsic origin in that their size and shape depend on an intrinsic mesoscopic feature of the 2D material: the polycrystalline grain size. We rationalize the relationship between grain size and wrinkle shape using continuum theory and minimal mathematical models. Finally, we demonstrate experimentally that the wrinkles alter the mechanical properties of the sheet, introducing dramatic softening and spatial heterogeneity in response to a point probe. The present work illuminates the mechanics of polycrystalline nanomaterials at extreme aspect ratios and suggests principles for engineering strain-controlled nanomechanical responses.</p>","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":" ","pages":""},"PeriodicalIF":15.8,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144511252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multivalence Driven High-Entropy Bimetallic Oxides for Acidic Water Oxidation.","authors":"Xianbing Miao, Liang Wu, Sheng Zhao, Jinhui Zhang, Zijiang Liu, Shiming Zhou","doi":"10.1021/acsnano.5c05602","DOIUrl":"https://doi.org/10.1021/acsnano.5c05602","url":null,"abstract":"<p><p>High-entropy materials have recently attracted much attention in diverse fields due to their tailorable compositions and unpredictable physicochemical properties. Generally, five or more metal elements occupying the same lattice sites in similar proportions are considered as a prerequisite for achieving high configuration entropy. Here we report an uncommon type of such material in V-doped RuO₂, where the number of metal elements is reduced to only two. Both Ru and V ions are found in mixed oxidation states, which endow the bimetallic oxides with five different cations. Each of these cations behaves as an individual species to contribute to the configuration entropy, which is high enough to stabilize the single phase near the half-doping level. The large ionic disorder in this high-entropy oxide leads to lattice distortion, grain refining, and an evolution from metal to semiconductor, making it a superior electrochemical catalyst toward acidic water oxidation.</p>","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":" ","pages":""},"PeriodicalIF":15.8,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144504127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-Performance Graphdiyne Oxide/Au Nanoparticle Electrode for Electrochemical Non-enzymatic Glucose Sensor.","authors":"Yu Zhou, Fuchun Nan, Zhaolei Li, Tengyu Yin, Bin Cai, Dan Huang, Lingyun Wang, William W Yu","doi":"10.1021/acsnano.5c05908","DOIUrl":"https://doi.org/10.1021/acsnano.5c05908","url":null,"abstract":"<p><p>Developing a convenient and high-performance blood glucose sensor is crucial for the effective diagnosis and management of diabetes. Sweat sensing offers a noninvasive method for detecting glucose levels; however, the complexities involved in enzyme immobilization and their sensitivity to environmental conditions during detection pose significant challenges in the development of enzyme-based sensors. Herein, this work proposes a graphdiyne oxide/gold nanoparticles (GDYO/AuNPs) composite electrode for nonenzyme glucose detection in sweat. The resulting sensor achieves a remarkable sensitivity (168 μA mM^-1 cm^-2), along with a low detection limit (4.11 μM). Such performance stems from the synergetic effect between AuNPs and the oxygen-rich functional groups of the GDYO substrate. This combination greatly enhances the dehydrogenation process during glucose oxidation. Moreover, the sensor exhibits superior selectivity with the coexistence of four other common substances in human sweat and maintains its glucose detection capabilities under neutral or slightly acidic conditions. Additionally, a GDYO/AuNPs-based wearable glucose sensor successfully monitors glucose fluctuations in human sweat both before and after meals, demonstrating a high correlation with blood glucose levels. Our findings provide a promising electrode for advancing nonenzymatic glucose sensors for in situ monitoring of sweat glucose.</p>","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":" ","pages":""},"PeriodicalIF":15.8,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144504124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stable Tensile-Strained Pt Single Atomic Layer Catalysts on α-MoC for Efficient Alkaline Hydrogen Evolution.","authors":"Yaohui Zhao, Jiapeng Huang, Ke Zhang, Yanan Li, Zixin Ge, Yangzi Zheng, Shangdong Ji, Junhao Lu, Yuan Ren, Chao Wu, Mingshang Jin","doi":"10.1021/acsnano.5c05972","DOIUrl":"https://doi.org/10.1021/acsnano.5c05972","url":null,"abstract":"<p><p>Developing Pt-based core-shell catalysts with ultralow Pt loading, superior performance, and extended durability holds tremendous potential for advancing electrochemical energy storage and conversion technologies. However, current synthetic limitations persist in achieving atomically efficient Pt monolayer deposition on nonprecious metal substrates, hindering the maximization of Pt atomic utilization for cost-effective catalyst design. Here, we demonstrate a galvanic replacement strategy to synthesize tensile-strained platinum single-atom-layer (Pt SAL) on α-MoC substrates. The Pt SAL catalysts enable cooperative catalysis between adjacent Pt sites while maintaining nearly 100% atomic utilization efficiency. For alkaline hydrogen evolution, the Pt SAL/α-MoC catalyst exhibits optimized reaction energetics, reducing activation barriers for water dissociation, hydrogen adsorption, and H₂ desorption compared to typical Pt/C. As a result, the Pt SAL catalysts exhibit superior hydrogen evolution reaction (HER) performance, with a mass activity of 1.71 A mg_Pt^-1 at an overpotential of 50 mV, surpassing commercial Pt/C by 6.35-fold and single-atom catalysts by 7.68-fold. Remarkably, the Pt SAL catalysts reveal negligible activity decay after 10,000 cycles, with density functional theory (DFT) calculations attributing this stability to strong Pt-Mo interfacial bonding. <i>In situ</i> Raman spectroscopic studies reveal dynamic interfacial water restructuring that accelerates reaction kinetics. This work establishes a versatile synthesis approach for noble metal SAL catalysts and explores their role in designing high-performance electrocatalysts for heterogeneous catalysis.</p>","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":" ","pages":""},"PeriodicalIF":15.8,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144511253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanomedicine and Spleen-Targeting Strategies for Precision Immunomodulation: Advances, Challenges, and Future Perspectives.","authors":"Chiwoo Oh, Han Na Jung, Jiwoo Park, John Mark Awad, Dawei Jiang, David J Dowling, Hyung-Jun Im","doi":"10.1021/acsnano.5c04836","DOIUrl":"https://doi.org/10.1021/acsnano.5c04836","url":null,"abstract":"<p><p>The spleen, which is the largest lymphoid organ, contains various immune cells and plays a crucial role in immunological responses. Because nanoparticles have a natural characteristic of being taken up by reticuloendothelial system (RES) organs, including the spleen, various spleen-targeting nanomedicine strategies have been developed for immunomodulatory therapies. Herein, we review the biological role of the spleen as part of the immune system, types of spleen-targeting nanoparticles, considerations for engineering both current and innovative spleen-targeting strategies, and their therapeutic potential in various diseases, including tumors and autoimmune diseases. Furthermore, we discuss the importance of systems immunology based approaches, including spatial transcriptomics, in achieving a comprehensive understanding of spleen-targeting strategies using nanomedicine.</p>","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":" ","pages":""},"PeriodicalIF":15.8,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144504128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In-Plane Anisotropic Two-Dimensional ReSe₂ Optoelectronic Memristor for a Polarization-Sensitive Neuromorphic Vision System.","authors":"Yongxing Zhu, Ye Tao, Zhongqiang Wang, Jingyao Bian, Zhuangzhuang Li, Meng Qi, Ya Lin, Xiaoning Zhao, Haiyang Xu, Yichun Liu","doi":"10.1021/acsnano.5c08221","DOIUrl":"https://doi.org/10.1021/acsnano.5c08221","url":null,"abstract":"<p><p>A polarization-sensitive neuromorphic vision system (PNVS) that synchronously possesses the capacities of polarized light perception and neuromorphic computing enables the detection of potential information or hidden features. While developing a polarization-sensitive optoelectronic memristor presents an intriguing avenue for building the foundational hardware of PNVS, it has proven challenging. In this work, a polarization-sensitive optoelectronic memristor based on the in-plane anisotropic two-dimensional ReSe₂ is proposed. Thanks to the meticulous device structure design, the angle-dependent synaptic plasticity of the device is demonstrated. Further, the image preprocessing and recognition functions are implemented under the circumstances of 0 and 90° polarized light, and the learning accuracy is improved from 81.1 to 86.8 and 90.4%, respectively. To reveal the mining capacity of hidden information, the surface flaw detection application is finally demonstrated through enhancement in the degree of linear polarization (DoLP). This study provides an approach to developing polarization-sensitive neuromorphic devices for future polarization vision systems used in intelligent vehicles and robot vision.</p>","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":" ","pages":""},"PeriodicalIF":15.8,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144511251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}