Nanoscale Horizons最新文献

Introduction to the editor's choice collection on inorganic-biomolecule nanomaterials. 介绍编辑的无机-生物分子纳米材料精选集。

IF 6.6 2区材料科学

Nanoscale Horizons Pub Date : 2025-10-02 DOI: 10.1039/d5nh90055g

Mark J MacLachlan

引用次数: 0

Sodium plating on hard carbon anodes in sodium-ion batteries: mechanisms, detection methods, and mitigation strategies. 钠离子电池硬碳阳极镀钠：机理、检测方法和缓解策略。

IF 6.6 2区材料科学

Nanoscale Horizons Pub Date : 2025-10-01 DOI: 10.1039/d5nh00471c

Feng Liu, Zihe Chen, Yuanjian Li, Lin Fu, Jiangwei Ju, Jun Ma, Yongming Sun

{"title":"Sodium plating on hard carbon anodes in sodium-ion batteries: mechanisms, detection methods, and mitigation strategies.","authors":"Feng Liu, Zihe Chen, Yuanjian Li, Lin Fu, Jiangwei Ju, Jun Ma, Yongming Sun","doi":"10.1039/d5nh00471c","DOIUrl":"https://doi.org/10.1039/d5nh00471c","url":null,"abstract":"Due to sodium's abundance and cost advantages, sodium-ion batteries (SIBs) are promising alternatives to lithium-ion batteries. The commercial adoption of hard carbon (HC) as an anode material-attributed to its low sodiation potential, high Na+ storage capacity, and extensive availability-further reinforces the potential of SIBs. Nevertheless, the inherent thermodynamic instability of HC anodes predisposes them to irreversible Na plating during operation. This phenomenon not only poses considerable safety hazards due to dendrite-induced short circuits but also accelerates capacity degradation, thereby undermining the feasibility of large-scale SIB deployment. This review comprehensively delineates the mechanisms underlying Na plating on HC anodes by examining internal factors-such as the electrode structure, the N/P ratio, and the electrolyte composition-and external factors including the state of charge, low temperature, and fast charging conditions. It further details various detection methods, encompassing both electrochemical techniques and physical characterization techniques, and outlines mitigation strategies such as electrode structure design, surface engineering, and electrolyte regulation to suppress plating. By synthesizing current understanding, the review posits future directions for developing safer, high-performance SIB anodes. Addressing Na plating is thus critical for advancing SIB technology toward large-scale applications.","PeriodicalId":93,"journal":{"name":"Nanoscale Horizons","volume":" ","pages":""},"PeriodicalIF":6.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145197403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Influence of hydrophilic polymers on the accelerated blood clearance of mRNA lipid nanoparticles upon repeated administration. 亲水聚合物对重复给药后加速血液中mRNA脂质纳米颗粒清除的影响。

IF 6.6 2区材料科学

Nanoscale Horizons Pub Date : 2025-10-01 DOI: 10.1039/d5nh00230c

Dayangku Nordiyana B P Hassanel, Yi Ju, Asuka Takanashi, Azizah Algarni, Chee Leng Lee, Stephen J Kent, Colin W Pouton, Emily H Pilkington

{"title":"Influence of hydrophilic polymers on the accelerated blood clearance of mRNA lipid nanoparticles upon repeated administration.","authors":"Dayangku Nordiyana B P Hassanel, Yi Ju, Asuka Takanashi, Azizah Algarni, Chee Leng Lee, Stephen J Kent, Colin W Pouton, Emily H Pilkington","doi":"10.1039/d5nh00230c","DOIUrl":"https://doi.org/10.1039/d5nh00230c","url":null,"abstract":"mRNA lipid nanoparticles (LNPs) have emerged as a leading delivery system for mRNA-based vaccines and therapeutics. However, a significant limitation of this system is the presence of poly(ethylene) glycol (PEG). It is widely known that repeated doses of PEG-based therapeutics can induce an anti-PEG antibody response, leading to the accelerated blood clearance (ABC) of LNP therapeutics requiring frequent dosing, as anti-PEG antibodies have been found present in a large proportion of the population. To address this issue, we developed a mouse model for LNP clearance after a repeated dose. We then synthesised LNPs with the PEG component replaced by a library of hydrophilic polymers: poly(oligo(ethylene glycol) methyl ether methacrylate) (POEGMA), POEGMA-methacrylic acid (POEGMA (-)), POEGMA-2-(dimethylamino)ethyl methacrylate (POEGMA (+)), poly(N,N-dimethylacrylamide) (PDMA), and poly(N-(2-hydroxypropyl) methacrylamide) (PHPMA). Our results demonstrated that all three POEGMA LNPs, especially POEGMA (+) LNPs, exhibited minimal ABC effect after two weekly doses; in contrast, PDMA LNPs demonstrated significantly lower clearance in the presence of anti-PEG antibodies. This study highlights the potential of PEG-free polymer-LNPs as promising mRNA carriers that avoid rapid clearance with repeated administration.","PeriodicalId":93,"journal":{"name":"Nanoscale Horizons","volume":" ","pages":""},"PeriodicalIF":6.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145197380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quantitative 2D fitting of fluorescence-excitation maps: excitation lineshape of single-wall carbon nanotubes. 荧光激发图的定量二维拟合：单壁碳纳米管的激发线形状。

IF 6.6 2区材料科学

Nanoscale Horizons Pub Date : 2025-10-01 DOI: 10.1039/d5nh00231a

Sofie Cambré, Wouter Van Werveke, Miguel De Clercq, Maksiem Erkens, Miles Martinati, Wim Wenseleers

{"title":"Quantitative 2D fitting of fluorescence-excitation maps: excitation lineshape of single-wall carbon nanotubes.","authors":"Sofie Cambré, Wouter Van Werveke, Miguel De Clercq, Maksiem Erkens, Miles Martinati, Wim Wenseleers","doi":"10.1039/d5nh00231a","DOIUrl":"https://doi.org/10.1039/d5nh00231a","url":null,"abstract":"Two-dimensional (2D) fluorescence-excitation (PLE) spectroscopy offers a powerful way to analyse samples of semiconducting single-wall carbon nanotubes (SWCNTs). The one-to-one correspondence between the SWCNT chiral structure and its optically excited states allows for the identification of individual species based on peaks in 2D PLE data. Changes in the position, width and other features of the lineshape associated with a given peak reveal a plethora of information about the associated SWCNT chirality and e.g. its interactions with the environment. Consistent and physically relevant quantification of that information requires accurate fitting of the 2D data, which has long been hindered by the fact that a sufficiently accurate functional form for the excitation profile of SWCNTs was not known. Here we present a highly accurate analytical empirical model for the excitation lineshape and combine it with one for the emission lineshape in a 2D fitting model that produces accurate fits of 2D PLE maps for any SWCNT sample and allows straightforward extraction of lineshape features, including peak positions, linewidths and intensities as well as other relevant physical quantities such as phonon sidebands in the emission and excitation spectra.","PeriodicalId":93,"journal":{"name":"Nanoscale Horizons","volume":" ","pages":""},"PeriodicalIF":6.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145197463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transformative therapy in acute microbial-induced colitis with inflammation triggered micelles and combination therapies. 炎症引发胶束的急性微生物性结肠炎的转化治疗和联合治疗。

IF 6.6 2区材料科学

Nanoscale Horizons Pub Date : 2025-09-30 DOI: 10.1039/d5nh00317b

Saman Ghazvini, Sepehr Hejazi, Saji Uthaman, Tyler Harm, Michael Wannemuehler, Rizia Bardhan

{"title":"Transformative therapy in acute microbial-induced colitis with inflammation triggered micelles and combination therapies.","authors":"Saman Ghazvini, Sepehr Hejazi, Saji Uthaman, Tyler Harm, Michael Wannemuehler, Rizia Bardhan","doi":"10.1039/d5nh00317b","DOIUrl":"https://doi.org/10.1039/d5nh00317b","url":null,"abstract":"Ulcerative colitis has no cure and there are limited options for patients. Many current therapeutic drugs have poor bioavailability and targeting ability, including inhibitors of the cGAS-STING pathway, which has limited their clinical approval for colitis. Here we address this critical need through inflammation-triggered nanomicelles (ITMs) that are composed of biopolymer hyaluronic acid which specifically targets the inflamed colon by binding to CD44 receptors. ITMs encapsulate the cGAS inhibitor RU.521 improving the drug's overall bioavailability, and utilize a reactive oxygen species (ROS)-responsive thioketal linker, enabling site-specific drug release at the inflamed colon. The efficacy of ITMs was shown in a clinically relevant microbial-induced colitis model that recapitulates human colitis. Acute colitis was developed in gnotobiotic altered Schaedler's flora (ASF) IL-10 knockout mice infected with Helicobacter bilis or Escherichia coli 1D to induce severe and moderate colitis, respectively. Oral delivery of ITMs alone significantly reduced inflammation in the E. coli 1D model, while combining ITMs with anti-IL-12p40 antibodies mitigated disease severity in the H. bilis model as revealed by body weight recovery, reduced colon shortening, restoration of the intestinal epithelium, and reduction in proinflammatory cytokines. In vivo end points were validated with ex vivo tissue imaging and assays that identified the downregulation of cGAS expression and other mechanisms by which ITMs enable mucosal healing. These findings highlight the potential of ITMs for targeted, site-specific drug delivery as a novel IBD treatment strategy, and the importance of inhibiting the cGAS-STING pathway in inflammatory diseases.","PeriodicalId":93,"journal":{"name":"Nanoscale Horizons","volume":" ","pages":""},"PeriodicalIF":6.6,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145190453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Surface nanostructures regulated by chalcogen bonding interactions. 由碳键相互作用调控的表面纳米结构。

IF 6.6 2区材料科学

Nanoscale Horizons Pub Date : 2025-09-30 DOI: 10.1039/d5nh00463b

Xinyi Zhang, Qiang Sun, Liangliang Cai, Andrew T S Wee

{"title":"Surface nanostructures regulated by chalcogen bonding interactions.","authors":"Xinyi Zhang, Qiang Sun, Liangliang Cai, Andrew T S Wee","doi":"10.1039/d5nh00463b","DOIUrl":"https://doi.org/10.1039/d5nh00463b","url":null,"abstract":"In recent years, chalcogen bonding (ChB) has emerged as a versatile tool for the bottom-up construction of functional nanostructures on surfaces. This minireview systematically explores the fundamental principles and recent advancements in ChB-directed on-surface synthesis. We highlight how ChB, characterized by its strong directionality and tunable interaction strength, complements conventional noncovalent interactions (hydrogen bonds, halogen bonds, and metal-ligand coordination) in engineering well-defined low-dimensional architectures. The key findings demonstrate ChB's unique capabilities in driving molecular recognition, controlling topology selectivity in conformationally flexible precursors, and facilitating disorder-to-order transitions in two-dimensional (2D) networks. Particularly, we discuss how surface confinement modifies ChB properties, enabling novel assembly pathways and reactivity in on-surface synthesis. By bridging fundamental ChB interactions and the practical implementation in on-surface nanotechnology, this minireview provides valuable insights for designing functional nanomaterials through rational ChB engineering, while outlining current challenges and future directions in this emerging field.","PeriodicalId":93,"journal":{"name":"Nanoscale Horizons","volume":" ","pages":""},"PeriodicalIF":6.6,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145190463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Light-triggered quenching of the ¹⁹F-MRI signal from micelle-encapsulated PERFECTA. 胶束封装PERFECTA的19F-MRI信号的光触发猝灭。

IF 6.6 2区材料科学

Nanoscale Horizons Pub Date : 2025-09-29 DOI: 10.1039/d5nh00468c

Claire Leterrier, Guillaume Pinna, Marie Vandamme, Mélissa Glatigny, Erwan Selingue, Françoise Geffroy, Sébastien Mériaux, Edmond Gravel, Eric Doris

引用次数: 0

Nanoscale Horizons Emerging Investigator Series: Dr Siqi Li, Anhui University, China. 纳米尺度地平线新兴研究者系列：李思琪博士，安徽大学，中国。

IF 6.6 2区材料科学

Nanoscale Horizons Pub Date : 2025-09-25 DOI: 10.1039/d5nh90053k

引用次数: 0

Flexible MXene-cellulose nanofiber based all-solid-state supercapacitors with high volumetric capacitance. 基于柔性mxene纤维素纳米纤维的高容量全固态超级电容器。

IF 6.6 2区材料科学

Nanoscale Horizons Pub Date : 2025-09-25 DOI: 10.1039/d5nh00285k

Yongzan Zhou, Youchao Teng, Huicong Liu, Yimin Wu

{"title":"Flexible MXene-cellulose nanofiber based all-solid-state supercapacitors with high volumetric capacitance.","authors":"Yongzan Zhou, Youchao Teng, Huicong Liu, Yimin Wu","doi":"10.1039/d5nh00285k","DOIUrl":"https://doi.org/10.1039/d5nh00285k","url":null,"abstract":"All-solid-state supercapacitors (ASSCs) are critical for next-generation flexible and wearable electronic devices, but their development has been hindered by the challenge of balancing high energy storage performance with mechanical flexibility in wearable energy storage systems. MXene materials offer excellent electrical conductivity, large surface area, and outstanding charge storage capability, but their application in flexible devices is limited by poor mechanical stability and structural degradation. To overcome these challenges, we have developed MXene/cellulose nanofiber (CNF) composites. CNF is a cheap and environmentally friendly material with a huge storage capacity on earth. The doping of CNFs into a layered MXene material prevents the stacking of the MXene, improves the ionic transport speed, maintains the excellent electrochemical properties of the MXene, and enhances the structural reinforcement and flexibility. The flexible, binder-free ASSCs have excellent electrochemical properties with a volumetric capacitance of 94.21 F cm-3. The electrochemical properties also showed no degradation in bending tests in the range of 30°-120°. The capacitance retention was 97.87% after 10 000 bending cycles at an angle of 60°. This work provides a scalable and green approach to fabricating high-performance MSCs and points the way to the next generation of wearable electronics.","PeriodicalId":93,"journal":{"name":"Nanoscale Horizons","volume":" ","pages":""},"PeriodicalIF":6.6,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145184236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Colloidal systems as experimental platforms for physics-informed machine learning. 胶体系统作为物理信息机器学习的实验平台。

IF 6.6 2区材料科学

Nanoscale Horizons Pub Date : 2025-09-25 DOI: 10.1039/d5nh00568j

Namhee Kang, Yeonseo Joo, Hyosung An, Hyerim Hwang

{"title":"Colloidal systems as experimental platforms for physics-informed machine learning.","authors":"Namhee Kang, Yeonseo Joo, Hyosung An, Hyerim Hwang","doi":"10.1039/d5nh00568j","DOIUrl":"https://doi.org/10.1039/d5nh00568j","url":null,"abstract":"Colloidal systems offer a unique experimental window for investigating condensed matter phenomena, uniquely enabling simultaneous access to microscopic particle dynamics and emergent macroscopic responses. Their particle-scale size, thermal motion, and tuneable interactions allow for real-time, real-space, and single-particle-resolved imaging. These features make it possible to directly connect local structural changes, dynamic rearrangements, and mechanical deformation with system-level behaviours. Such capabilities remain largely inaccessible in atomic or molecular systems. This review presents colloidal modelling as a predictive framework that addresses persistent challenges in materials research, including phase classification, dynamic arrest, and defect-mediated mechanics. We describe methodologies for extracting structural, dynamical, and mechanical descriptors from experimental imaging data, show how these features capture governing variables of material behaviour, and illustrate their application in machine learning approaches for phase identification, dynamics prediction, and inverse design. Rather than treating colloidal data as limited to model systems, we emphasize its value as a training ground for developing interpretable and physics-informed models. By linking microscopic mechanisms with macroscopic observables in a single experimental system, colloids generate structured and generalizable datasets. Their integration with data-driven methods offer a promising pathway toward predictive and transferable materials design strategies.","PeriodicalId":93,"journal":{"name":"Nanoscale Horizons","volume":" ","pages":""},"PeriodicalIF":6.6,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145136027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0