Nanoscale Horizons最新文献_第10页

Rolling circle amplification/transcription-based nanotechnology for efficient delivery of nucleic acid drugs 基于滚动圈扩增/转录的纳米技术用于核酸药物的有效递送。

IF 6.6 2区材料科学

Nanoscale Horizons Pub Date : 2025-07-08 DOI: 10.1039/D5NH00364D

Xun You, Qingxuan Zeng, Tianshuang Xia, Xiaocui Guo, Chi Yao and Dayong Yang

{"title":"Rolling circle amplification/transcription-based nanotechnology for efficient delivery of nucleic acid drugs","authors":"Xun You, Qingxuan Zeng, Tianshuang Xia, Xiaocui Guo, Chi Yao and Dayong Yang","doi":"10.1039/D5NH00364D","DOIUrl":"10.1039/D5NH00364D","url":null,"abstract":"Rolling circle amplification/transcription (RCA/RCT) nanotechnology offers a breakthrough platform for nucleic acid drug delivery, leveraging enzymatically produced ultra-long, programmable nucleic acid chains to engineer multifunctional nanostructures. In this review, we give an overview of RCA/RCT-based nanocarriers for nucleic acid drug delivery, systematically summarizing their key design aspects: (1) nanoization strategies through biomineralization, electrostatic compression, nanomaterial-assisted assembly and base pairing/entanglement; (2) drug loading approaches via design on template, complementary base pairing and electrostatic binding; (3) targeting modalities including aptamers, proteins, polymers and small molecule ligands; and (4) controlled release mechanisms responsive to endogenous/exogenous enzymes and intracellular microenvironments. We showcase their significant therapeutic advances in gene therapy, immunotherapy, and combination therapy. This overview provides critical insights for developing next-generation RCA/RCT delivery platforms to address pressing biomedical needs.","PeriodicalId":93,"journal":{"name":"Nanoscale Horizons","volume":" 10","pages":" 2285-2303"},"PeriodicalIF":6.6,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144673334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Conformation driven conductance modulation in single-stranded RNA (ssRNA)† 单链RNA （ssRNA）构象驱动的电导调制。

IF 6.6 2区材料科学

Nanoscale Horizons Pub Date : 2025-07-04 DOI: 10.1039/D5NH00241A

Arpan De, Arindam K. Das and M. P. Anantram

{"title":"Conformation driven conductance modulation in single-stranded RNA (ssRNA)†","authors":"Arpan De, Arindam K. Das and M. P. Anantram","doi":"10.1039/D5NH00241A","DOIUrl":"10.1039/D5NH00241A","url":null,"abstract":"The structural attributes of RNA, especially co-transcriptional folding, have enabled RNA origami to construct complex 3D architectures, serving as a platform to build RNA-based nanodevices. However, the potential of RNA in molecular electronics is largely unexplored, mainly due to its inherent conformational fluctuations. Although this variability poses challenges for a precise understanding of the conductance properties of RNA, it also offers opportunities for tuning RNA-based molecular devices by exploiting their dynamic nature. Accordingly, our objectives in this paper are twofold: (i) how do conformational fluctuations impact the charge transport properties of single stranded RNA (ssRNA), and (ii) how can these fluctuations be controlled? Toward that end, we first established a benchmark for ssRNA instability compared to double stranded RNA (dsRNA) based on molecular dynamics. Subsequently, we explore quantum transport across 123 distinct conformations, which show that the average conductance of ssRNA is 1.7 × 10−3 G0, but with a high standard deviation of around 5.2 × 10−3G0. We demonstrate that the conductance of ssRNA is influenced primarily by backbone bending and nucleotide positioning. Specifically, while backbone bending tends to result in higher conductance at reduced end-to-end phosphorus distances, nucleotide positioning introduces significant stochasticity. To mitigate this variability, we also demonstrate that increasing the salt concentration can stabilize ssRNA, presenting a viable strategy for minimizing conductance fluctuations. Our findings reveal that if ssRNA conductance can be switched between folded and unfolded states, it can offer two distinct conductance modes. We anticipate the programmability of ssRNA folding and durability, coupled with its conductivity, can be leveraged for advancing molecular electronics.","PeriodicalId":93,"journal":{"name":"Nanoscale Horizons","volume":" 9","pages":" 2080-2093"},"PeriodicalIF":6.6,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/nh/d5nh00241a?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144558529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High-performance optoelectronics enabled by solution-based sintering of perovskite nanocrystals† 钙钛矿纳米晶体的溶液烧结实现了高性能光电器件。

IF 6.6 2区材料科学

Nanoscale Horizons Pub Date : 2025-07-04 DOI: 10.1039/D5NH00272A

Karthika Vijayan, Yu-Xiang Chen, Pradyumna Kumar Chand, Ting-Chun Huang, Ya-Ping Hsieh and Mario Hofmann

{"title":"High-performance optoelectronics enabled by solution-based sintering of perovskite nanocrystals†","authors":"Karthika Vijayan, Yu-Xiang Chen, Pradyumna Kumar Chand, Ting-Chun Huang, Ya-Ping Hsieh and Mario Hofmann","doi":"10.1039/D5NH00272A","DOIUrl":"10.1039/D5NH00272A","url":null,"abstract":"Perovskite nanocrystals have emerged as promising constituents for optoelectronic applications due to their exceptional and tunable properties and their scalable synthesis. However, their integration into devices faces challenges such as defects, poor carrier transport, and ligand interference. We present a liquid-in-liquid impingement process that achieves the mechanical coalescence of lead–bromide perovskite nanocrystals into large, free-standing flakes under ambient conditions. This approach leverages localized shear forces generated during impingement to achieve nanocrystal sintering, ligand removal, and solvent exchange. Microscopic analysis reveals the formation of large surface-sintered domains that overcome previous issues of defectiveness and environmental stability. This process results in significant improvements of the sintered nanocrystal properties compared to random perovskite assemblies. We demonstrate a significant decrease in trap density leading to enhanced chemical stability, charge transport and radiative charge recombination. Enhancements in carrier mobility enable the fabrication of photodetectors with exceptional response speed and sensitivity, surpassing conventional methods. These findings highlight the potential of liquid impingement processing for advancing perovskite-based optoelectronics through scalable and efficient nanocrystal assembly.","PeriodicalId":93,"journal":{"name":"Nanoscale Horizons","volume":" 9","pages":" 2104-2110"},"PeriodicalIF":6.6,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144574508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis planning for atomically precise metal nanoclusters 原子精密金属纳米团簇的合成规划。

IF 6.6 2区材料科学

Nanoscale Horizons Pub Date : 2025-07-03 DOI: 10.1039/D5NH00353A

Jingkuan Lyu, Jing Qian, Zhucheng Yang and Jianping Xie

{"title":"Synthesis planning for atomically precise metal nanoclusters","authors":"Jingkuan Lyu, Jing Qian, Zhucheng Yang and Jianping Xie","doi":"10.1039/D5NH00353A","DOIUrl":"10.1039/D5NH00353A","url":null,"abstract":"The rational design and synthesis of materials with tailored properties remains a long-standing goal in advanced materials science. Metal nanoclusters (MNCs), distinguished by their atomic precision and molecule-like properties—including discrete energy levels, strong photoluminescence, and high property tunability—represent promising platforms for applications spanning catalysis to biomedicine. This perspective presents a comprehensive synthesis planning framework comprising three critical stages, i.e., target design, route development, and condition optimization, systematically addressing MNC rational design and synthesis with special emphasis on thiolate-protected gold nanoclusters as exemplary systems. We first discuss design considerations for core and ligand shell engineering based on their profound influence on overall material properties. Subsequently, we examine methods and synthetic mechanisms for atomic-level tailoring of core and ligand shells to achieve target MNC synthesis. We then elucidate condition parameter tuning considerations based on their deterministic roles in reaction outcomes. While this structured approach provides a systematic methodology for MNC development, significant challenges persist owing to the high structural and synthetic complexity of MNCs. We then discuss the opportunities brought by recent advances in machine learning and high-throughput experimentation, which have demonstrated potential in addressing these challenges based on their superior computational and data analytical capabilities. We advocate for systematic adoption of this synthesis planning approach enhanced by data-driven methods, addressing inherent limitations in future development to better exploit these integrated approaches for accelerating rational MNC design and synthesis.","PeriodicalId":93,"journal":{"name":"Nanoscale Horizons","volume":" 10","pages":" 2304-2339"},"PeriodicalIF":6.6,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144688407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Doped-graphdiyne: synthesis, theoretical prediction and application for electrochemical energy storage 掺杂石墨炔：电化学储能的合成、理论预测及应用。

IF 6.6 2区材料科学

Nanoscale Horizons Pub Date : 2025-07-03 DOI: 10.1039/D5NH00201J

Ziqi Chen, Deyi Zhang, Ze Yang, Yan Xu, Xuqi Wang, Hao Huang, Fangcheng Qiu and Changshui Huang

{"title":"Doped-graphdiyne: synthesis, theoretical prediction and application for electrochemical energy storage","authors":"Ziqi Chen, Deyi Zhang, Ze Yang, Yan Xu, Xuqi Wang, Hao Huang, Fangcheng Qiu and Changshui Huang","doi":"10.1039/D5NH00201J","DOIUrl":"10.1039/D5NH00201J","url":null,"abstract":"Graphdiyne (GDY), an emerging carbon allotrope with sp–sp2 hybridized networks, possesses a distinctive hierarchical architecture combining two-dimensional planar conjugation with three-dimensional porous frameworks. This unique configuration, characterized by abundant acetylene linkages and uniformly distributed nanopores, provides exceptional advantages for metal ion intercalation kinetics and heteroatomic integration. However, the material's development is constrained by morphological homogeneity and insufficient defect density. To expand the functional versatility of GDY-based systems and engineer enhanced storage capacities through defect engineering, strategic heteroatom doping has emerged as a pivotal modification strategy. Recent advancements in GDY functionalization have demonstrated remarkable progress in tailoring its electrochemical properties via atomic-scale modifications. This review systematically analyzes contemporary synthetic approaches for heteroatom incorporation in GDY matrices, including single-element doping, functional group grafting, and heteroatomic anchoring techniques. Furthermore, we critically evaluate theoretical simulations elucidating doping mechanisms and summarize cutting-edge applications in metal-ion battery systems. Through comprehensive discussion of structure–property relationships in doped GDY electrodes, this work aims to stimulate innovative designs of advanced carbon architectures for next-generation energy storage technologies","PeriodicalId":93,"journal":{"name":"Nanoscale Horizons","volume":" 10","pages":" 2239-2261"},"PeriodicalIF":6.6,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144598856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanozymes: recent advances for sustainable agricultural development 纳米酶：可持续农业发展的最新进展。

IF 6.6 2区材料科学

Nanoscale Horizons Pub Date : 2025-07-03 DOI: 10.1039/D5NH00281H

Runxin Hou, Na Yin, Yinghui Wang, Shuyan Song and Hongjie Zhang

{"title":"Nanozymes: recent advances for sustainable agricultural development","authors":"Runxin Hou, Na Yin, Yinghui Wang, Shuyan Song and Hongjie Zhang","doi":"10.1039/D5NH00281H","DOIUrl":"10.1039/D5NH00281H","url":null,"abstract":"Agricultural production is currently facing numerous abiotic and biotic stresses. To mitigate the impacts of these stresses on crop yields, conventional agrochemicals have been widely employed to support farming practices. However, these chemicals exhibit limited functionality and are prone to overuse and residue accumulation on agricultural products, leading to environmental concerns such as pollution and bioaccumulation, which may hinder the development of sustainable agriculture. These drawbacks restrict their broader application in future sustainable agricultural systems. Notably, nanozymes possess unique advantages, including enhanced stability, tunable catalytic activity, and functional versatility. They exhibit significant potential in optimizing plant growth environments, mitigating stress conditions and enhancing crop stress resistance. As a promising alternative, nanozymes demonstrate the capability to address the limitations of conventional agrochemicals while advancing sustainable agricultural practices. Building on this progress, this review first explores the essential properties required for nanozyme applications in agriculture. It further categorizes nanozymes based on their diverse catalytic activities and discusses their roles in sustainable agricultural practices. Additionally, this review addresses current challenges in the field and proposes future directions for nanozyme-based agrochemicals. The goal is to deepen readers’ understanding of recent advances in agricultural nanozymes and stimulate broader scientific interest to explore their potential to advance sustainable agriculture. It is also hoped to provide some constructive inspirations for subsequent scientific research.","PeriodicalId":93,"journal":{"name":"Nanoscale Horizons","volume":" 10","pages":" 2184-2210"},"PeriodicalIF":6.6,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144657861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances in computational approaches for bridging theory and experiments in electrocatalyst design 电催化剂设计中桥接理论与实验计算方法的进展。

IF 6.6 2区材料科学

Nanoscale Horizons Pub Date : 2025-07-02 DOI: 10.1039/D5NH00216H

Yaqin Zhang, Yu Xiong, Yuhang Wang, Qianqian Wang and Jun Fan

{"title":"Advances in computational approaches for bridging theory and experiments in electrocatalyst design","authors":"Yaqin Zhang, Yu Xiong, Yuhang Wang, Qianqian Wang and Jun Fan","doi":"10.1039/D5NH00216H","DOIUrl":"10.1039/D5NH00216H","url":null,"abstract":"The activation of inert molecules such as CO2, N2, and O2 is central to addressing global energy and environmental challenges via electrocatalysis. However, their intrinsic stability and the complex solid–liquid interfacial phenomena present formidable obstacles for catalyst design. Recent advances in computational approaches are beginning to bridge the longstanding gap between idealized theoretical models and experimental realities. In this review, we highlight the progress made in scaling relations and descriptor-based screening methods, which underpin the Sabatier principle and volcano plot frameworks, enabling rapid identification of promising catalytic materials. We further discuss the evolution of thermodynamic and kinetic models—including the computational hydrogen electrode model, constant electrode potential model, and ab initio thermodynamics—that allow for accurate predictions of reaction energetics and catalyst stability under realistic operating conditions. Moreover, the advent of constant potential simulations and explicit solvation models, bolstered by ab initio molecular dynamics and machine learning-accelerated molecular dynamics, has significantly advanced our understanding of the dynamic electrochemical interface. High-throughput computational workflows and data-driven machine learning techniques have further streamlined catalyst discovery by efficiently exploring large material spaces and complex reaction pathways. Together, these computational advances not only provide mechanistic insights into inert molecule activation but also offer a robust platform for guiding experimental efforts. The review concludes with a discussion of remaining challenges and future opportunities to further integrate computational and experimental methodologies for the rational design of next-generation electrocatalysts.","PeriodicalId":93,"journal":{"name":"Nanoscale Horizons","volume":" 10","pages":" 2211-2238"},"PeriodicalIF":6.6,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144537469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cu–phytic acid nanozyme-induced cuproptosis therapy for the inhibition of tumor growth† 铜植酸纳米酶诱导的铜增生疗法对肿瘤生长的抑制作用。

IF 6.6 2区材料科学

Nanoscale Horizons Pub Date : 2025-07-01 DOI: 10.1039/D5NH00183H

Xiao-Wan Han, Xu Chen, Tian-Le Yang, Ying-Yi Luo, Rui-Xue Liang, San-Qi An and Xin-Li Liu

{"title":"Cu–phytic acid nanozyme-induced cuproptosis therapy for the inhibition of tumor growth†","authors":"Xiao-Wan Han, Xu Chen, Tian-Le Yang, Ying-Yi Luo, Rui-Xue Liang, San-Qi An and Xin-Li Liu","doi":"10.1039/D5NH00183H","DOIUrl":"10.1039/D5NH00183H","url":null,"abstract":"Cuproptosis has recently received much attention in cancer treatment. However, copper ionophores do not show any obvious clinical efficacy. Although some Cu-based and copper ionophore-loaded nanomaterials have been applied to induce cuproptosis, it is difficult to achieve their clinical translation as they are limited by their complicated composition, harsh synthesis conditions, requirement of external stimuli, and potential biotoxicity. Phytic acid, a naturally occurring organic phosphorus carbohydrate, possesses a distinct antineoplastic effect on multiple types of cancer and high biocompatibility. Based on metal–phosphonate coordination, a novel Cu–phytic acid nanozyme (denoted as CP) with a pH/GSH dual response was fabricated by a “one-pot” method. CP with three enzyme-mimicking activities enhanced cuproptosis therapy through GSH depletion, reactive oxygen species augmentation, hypoxia relief and the attenuation of glycolysis. As a proof of concept, Elesclomol (a copper ionophore)-resistant A549 cells were used to investigate CP-induced cuproptosis for the inhibition of tumor growth in vitro and in vivo.","PeriodicalId":93,"journal":{"name":"Nanoscale Horizons","volume":" 9","pages":" 2111-2122"},"PeriodicalIF":6.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144598855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spiking frequency adaptability and multi-weight synergy in artificial neuronal modules via bifunctional NbOx memristors† 基于双功能NbOx记忆电阻器的人工神经元模块的峰值频率适应性和多权重协同。

IF 6.6 2区材料科学

Nanoscale Horizons Pub Date : 2025-06-26 DOI: 10.1039/D5NH00268K

Shuai-Ming Chen, Li-Chung Shih, Jing-Ci Gao, Song-Xian You, Kuan-Ting Chen, Pei-Lin Lin, Kai-Shin Hsu, Chi-Chien Chen, Wei-Lun Chen and Jen-Sue Chen

{"title":"Spiking frequency adaptability and multi-weight synergy in artificial neuronal modules via bifunctional NbOx memristors†","authors":"Shuai-Ming Chen, Li-Chung Shih, Jing-Ci Gao, Song-Xian You, Kuan-Ting Chen, Pei-Lin Lin, Kai-Shin Hsu, Chi-Chien Chen, Wei-Lun Chen and Jen-Sue Chen","doi":"10.1039/D5NH00268K","DOIUrl":"10.1039/D5NH00268K","url":null,"abstract":"To address the limitations of current artificial neurons in neuromorphic hardware implementation, NbOx-based bifunctional memristors are fabricated to construct oscillatory units and advanced neuronal modules. NbOx-based memristors operate as either threshold-switching memristors (TSMs) or dynamic memristors (DyMs), depending on whether electroforming is applied. TSMs are employed to build oscillatory units and further reconfigured into a weighted multi-terminal neuronal module, enabling real-time spatiotemporal summation of input spikes based on the leaky integrate-and-fire model. This module demonstrated the capability to perform spike summation and multi-weight synergy. Leveraging the gradual resistance change characteristic of DyMs, a sequential encoder is implemented, allowing the system to recognize and respond to the temporal order of spiking signals. Additionally, a DyM is integrated into the oscillatory unit to construct intensification and attenuation neurons, enabling short-term spiking frequency adaptation. The versatile spiking performance of our NbOx bifunctional memristor provides a strategic foundation for developing artificial neurons for next-generation bio-inspired spiking neural networks.","PeriodicalId":93,"journal":{"name":"Nanoscale Horizons","volume":" 9","pages":" 2068-2079"},"PeriodicalIF":6.6,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144558545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advancements in separator materials for aqueous zinc batteries 水锌电池隔膜材料的研究进展。

IF 6.6 2区材料科学

Nanoscale Horizons Pub Date : 2025-06-25 DOI: 10.1039/D5NH00172B

Qingshun Nian, Xinru Yang, Hu Hong, Peng Chen, Yuwei Zhao, Haiming Lv and Chunyi Zhi

{"title":"Advancements in separator materials for aqueous zinc batteries","authors":"Qingshun Nian, Xinru Yang, Hu Hong, Peng Chen, Yuwei Zhao, Haiming Lv and Chunyi Zhi","doi":"10.1039/D5NH00172B","DOIUrl":"10.1039/D5NH00172B","url":null,"abstract":"Aqueous zinc (Zn) batteries (AZBs) are becoming promising candidates for grid-scale energy storage because of their inherent safety, cost-effectiveness, and high theoretical capacity. However, their widespread application is hindered by critical challenges, including Zn dendrite formation, hydrogen evolution reaction (HER), corrosion, and cathode material dissolution. The separator plays a crucial role in regulating ion transport, suppressing side reactions, and promoting uniform Zn deposition. While recent advancements in separator design have introduced various modification strategies to enhance electrochemical performance, a systematic classification based on the modification location remains lacking. This review provides a comprehensive analysis of recent advancements in AZB separators, categorized by modification position—anode side, cathode side, and full-separator modifications. Key modification strategies, including ion-selective layers, interfacial engineering, and composite functional membranes, are discussed in detail, with an emphasis on their effects on Zn2+ flux regulation, dendrite suppression, and long-term cycling stability. Additionally, emerging separator materials such as covalent organic frameworks (COFs), metal–organic frameworks (MOFs), and inorganic–organic hybrid separators are highlighted for their potential in optimizing battery performance. By elucidating the underlying mechanisms governing separator modifications, this review provides theoretical insights and design principles for the development of next-generation AZB separators. Finally, we discuss future research directions, focusing on separator thinness, enhanced ion selectivity, interface stability, corrosion resistance, and scalable manufacturing to accelerate the commercialization of high-performance AZBs.","PeriodicalId":93,"journal":{"name":"Nanoscale Horizons","volume":" 9","pages":" 1932-1955"},"PeriodicalIF":6.6,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144574507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0