Crystal Growth & Design最新文献

{"title":"Magnetostructural Correlation in Trigonal Bipyramidal Fe(III) Complexes: Tuning Spin-State Stability and Magnetic Anisotropy via Second Coordination Sphere Substitution","authors":"Shalini Joshi,&nbsp;Sabyasachi Roy Chowdhury and Sabyashachi Mishra*,&nbsp;","doi":"10.1021/acs.cgd.5c0011010.1021/acs.cgd.5c00110","DOIUrl":"https://doi.org/10.1021/acs.cgd.5c00110https://doi.org/10.1021/acs.cgd.5c00110","url":null,"abstract":"<p >The spin-dependent properties of the transition-metal complexes are strongly influenced by modifications of the first coordination sphere. However, the role of the second coordination sphere in governing these phenomena has remained relatively underexplored. In this study, the ground spin state stability and magnetic anisotropy of 33 trigonal bipyramidal (TBP) iron(III) complexes are examined, starting from the reference complex <i></i><math><msub><mrow><mo>(</mo><msub><mrow><mi>P</mi><mi>M</mi><mi>e</mi></mrow><mn>3</mn></msub><mo>)</mo></mrow><mn>2</mn></msub><msub><mrow><mi>F</mi><mi>e</mi><mi>C</mi><mi>l</mi></mrow><mn>3</mn></msub></math>, using a combination of density functional theory (DFT) and multiconfigurational methods. The spin–orbit coupling is evaluated <i>a posteriori</i>. The complexes were modeled by systematically substituting the second-coordination sphere, i.e., replacing the methyl groups of the phosphine ligands with various alkyl, alkoxy, and acyl groups of increasing bulkiness. Magnetostructural correlations are employed to investigate the impact of these substitutions on the ground spin state and magnetic anisotropy. The effects of structural parameters, such as the axial angle deviation, Tolman cone angle, equatorial deviation parameter, and continuous shape measurement, are explored on the orbital ordering, the energetics of scalar-relativistic and spin–orbit states, zero-field splitting parameters, <i>g</i>-tensors, and the effective magnetic anisotropy barriers. Our investigation reveals that the magnetic anisotropy of these complexes can be systematically enhanced by tuning the second coordination sphere. This can be achieved through a balanced combination of ligand substitutions that account for steric effects and electron-donating or electron-withdrawing properties, offering important guidelines for designing efficient single-ion magnets.</p>","PeriodicalId":34,"journal":{"name":"Crystal Growth & Design","volume":"25 8","pages":"2602–2616 2602–2616"},"PeriodicalIF":3.2,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143832889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioactive Ionic Cocrystals of Sitagliptin: Structural Characterization, Stability Analysis, and Molecular Docking Studies","authors":"Chunling Liu,&nbsp;Yijie Ma,&nbsp;Shenshen Du,&nbsp;Xingjun Ou,&nbsp;Junhao Sun,&nbsp;Xiang Lian,&nbsp;Lixing Song* and Fanhong Wu*,&nbsp;","doi":"10.1021/acs.cgd.5c0016110.1021/acs.cgd.5c00161","DOIUrl":"https://doi.org/10.1021/acs.cgd.5c00161https://doi.org/10.1021/acs.cgd.5c00161","url":null,"abstract":"<p >In this work, ionic cocrystals of sitagliptin, using inorganic salts as coformers, were prepared via mechanochemical and solution chemistry methods. The crystal structures were determined through single-crystal X-ray diffraction analysis, and intermolecular interactions were examined using Hirshfeld surface analysis. Thermal analysis and slurry experiments demonstrated that two ionic cocrystals exhibit excellent thermal and solution stability. Additionally, molecular docking studies provided evidence of the enhanced bioactivity of the ionic cocrystals.</p>","PeriodicalId":34,"journal":{"name":"Crystal Growth & Design","volume":"25 8","pages":"2683–2690 2683–2690"},"PeriodicalIF":3.2,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143832623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Distinctive Magnetic Relaxation Behavior of Ln(III) Single-Molecule Magnets with a Conducting Organic π Donor System","authors":"Nobuto Funakoshi*,&nbsp;Masanori Wakizaka,&nbsp;Qingyun Wan,&nbsp;Yongbing Shen,&nbsp;Haitao Zhang,&nbsp;Hiroshi Ito,&nbsp;Hiroaki Iguchi,&nbsp;Ryuta Ishikawa,&nbsp;Yoji Horii,&nbsp;Brian K. Breedlove,&nbsp;Shinya Takaishi and Masahiro Yamashita*,&nbsp;","doi":"10.1021/acs.cgd.5c0012010.1021/acs.cgd.5c00120","DOIUrl":"https://doi.org/10.1021/acs.cgd.5c00120https://doi.org/10.1021/acs.cgd.5c00120","url":null,"abstract":"<p >It is expected that single-molecule magnets (SMMs) containing Lanthanoids play an important role in high-density magnetic devices. In this work, we synthesized new conductive Ln(III) SMMs, (TMTSF)₄[Ln(NCS)₆](CH₃CN)₂(CH₂Cl₂)_0.5 (H₂O)_0.5 (TMTSF = (tetramethyltetraselenafulvalene), Ln(III) = Dy <b>(1)</b> and Tb <b>(2)</b>), which have organic TMTSF π donors as the conducting part. The crystal structure has high symmetry, and lanthanoid complexes form a lattice-like structure with the TMTSF donor. [Ln(NCS)₆]^3– forms a distorted octahedron due to S···Se contact with the TMTSF. The compound undergoes fast magnetic relaxation in the low-temperature region, and its relaxation time τ is almost independent of the temperature. The change in rate is nearly linear. The compounds show semiconductive behavior and a weak magnetoresistance effect at ambient and high pressure at the low temperatures.</p><p >It is expected that Single-Molecule-Magnets (SMMs) containing Lanthanoids play an important role in high-density magnetic devices. In this work, we synthesized new conductive Ln(III) SMMs, (TMTSF)₄[Ln(NCS)₆](CH₃CN)₂(CH₂Cl₂)_0.5 (H₂O)_0.5 (TMTSF = (tetramethyltetraselenafulvalene), Ln(III) = Dy <b>(1)</b> and Tb <b>(2)</b>), which have organic TMTSF π donors as the conducting part. The crystal structure has high symmetry, and lanthanoid complexes form a lattice-like structure with the TMTSF donor. [Ln(NCS)₆]³⁻ forms a distorted octahedron due to S···Se contact with the TMTSF. The compound undergoes fast magnetic relaxation in the low-temperature region, and its relaxation time τ is almost independent of the temperature. The change in rate is nearly linear. The compounds show semiconductive behavior and a weak magnetoresistance effect at ambient and high pressure at the low temperatures.</p>","PeriodicalId":34,"journal":{"name":"Crystal Growth & Design","volume":"25 8","pages":"2650–2656 2650–2656"},"PeriodicalIF":3.2,"publicationDate":"2025-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acs.cgd.5c00120","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143832683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Developing a Vial-Scale Methodology for the Measurement of Nucleation Kinetics Using Evaporative Crystallization: A Case Study with Sodium Chloride","authors":"Michele Chen,&nbsp;Leif-Thore Deck,&nbsp;Luca Bosetti and Marco Mazzotti*,&nbsp;","doi":"10.1021/acs.cgd.4c0172210.1021/acs.cgd.4c01722","DOIUrl":"https://doi.org/10.1021/acs.cgd.4c01722https://doi.org/10.1021/acs.cgd.4c01722","url":null,"abstract":"<p >Understanding nucleation kinetics is vital for designing crystallization processes, yet traditional measurement methods based on cooling are unsuitable for compounds with temperature-independent solubility. This study introduces an experimental procedure to measure the nucleation kinetics based on evaporative crystallization and applies it to sodium chloride (NaCl) in water. By systematically varying the experimental conditions such as temperature and evaporation gas flow rate, we obtained a comprehensive data set for the nucleation of NaCl crystals that allowed estimating kinetic parameters using a rate expression derived from classical nucleation theory (CNT). This work demonstrates the robustness of evaporation as a method for measuring the nucleation kinetics that is applicable regardless of how the solubility of a compound depends on the temperature.</p><p >This study introduces a vial-scale evaporative crystallization method to measure nucleation kinetics applied to aqueous sodium chloride (NaCl). By integrating experimental data and classical nucleation theory, it highlights the influence of evaporation rates on supersaturation and metastable zone width. The method demonstrates reproducibility and scalability, offering a robust framework for crystallization studies.</p>","PeriodicalId":34,"journal":{"name":"Crystal Growth & Design","volume":"25 8","pages":"2498–2509 2498–2509"},"PeriodicalIF":3.2,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acs.cgd.4c01722","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143832860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Crystallization Behavior of Plant-Based Fat Blends Formulated as an Alternative for Anhydrous Milk Fat in Milk Chocolate","authors":"Cecilia Fiore,&nbsp;Tom Rutherford,&nbsp;Francesca Giuffrida,&nbsp;Cynthia Marmet and Elena Simone*,&nbsp;","doi":"10.1021/acs.cgd.5c0022710.1021/acs.cgd.5c00227","DOIUrl":"https://doi.org/10.1021/acs.cgd.5c00227https://doi.org/10.1021/acs.cgd.5c00227","url":null,"abstract":"<p >Due to the increasing global demand for chocolate products and changes in consumer preferences, chocolate manufacturers have recently started to explore novel solutions to reformulate chocolate. Milk fat alternatives (MFA) are blends of triglycerides from different plant-based sources that resemble anhydrous milk fat in physical properties, particularly thermal behavior and solid fat content. However, in order to use MFA as potential ingredients for vegan milk chocolate formulations, it is necessary to understand their crystallization behavior, particularly in light of their chemical composition. Here, we applied synchrotron X-ray scattering, polarized light microscopy, and differential scanning calorimetry to investigate the crystallization behavior of four selected commercial MFAs (MF1, 2, 3, and 4), on their own and mixed with cocoa butter (CB). Chemical characterization revealed significant differences among samples and with both anhydrous milk fat (MF) and CB. POP-rich MF1 presented a specific polymorphic and thermal behavior, with the unstable β′ form persisting for longer times than all other samples. Sample MF2 exhibited a polymorphic behavior more similar to CB in terms of number, type, and melting behavior due to the compositional similarities (e.g., prevalence of both SOS and POP). SOS-rich MF3 was characterized by metastable forms γ and β′(3L), whereas MF4 at ambient conditions showed only β(2L) forms due to its specific composition. Mixtures of CB and all MFAs behaved similarly to CB and MF mixtures, with good miscibility at ambient temperature and a lower melting point. Despite significant differences in chemical composition, MF4 presented similar solid fat content compared to MF; this is due to the high amount of relatively long chain, unsaturated fatty acids and the broad distribution of different TAGs, which all lower the melting point of this sample.</p><p >This work investigates the crystallization behavior (polymorphic landscape and thermal properties) of different plant-based mixtures of triacylglycerides that can be used as milk fat replacers in chocolate formulations. X-ray scattering, differential scanning calorimetry, and polarized light microscopy were used as characterization techniques.</p>","PeriodicalId":34,"journal":{"name":"Crystal Growth & Design","volume":"25 8","pages":"2700–2716 2700–2716"},"PeriodicalIF":3.2,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acs.cgd.5c00227","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143832799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Amine-Functionalized Metal–Organic Frameworks for Highly Selective and Sensitive Detection of Salicylaldehyde","authors":"Xueting Huang,&nbsp;Lin Yuan,&nbsp;Wenjing Wang* and Daqiang Yuan*,&nbsp;","doi":"10.1021/acs.cgd.5c0010510.1021/acs.cgd.5c00105","DOIUrl":"https://doi.org/10.1021/acs.cgd.5c00105https://doi.org/10.1021/acs.cgd.5c00105","url":null,"abstract":"<p >Salicylaldehyde, a widely utilized compound in various industries, poses significant environmental and health risks. This study presents the development of a highly selective and sensitive fluorescent probe based on amine-functionalized metal–organic frameworks (<b>Eu-MOF</b>) for detecting salicylaldehyde. The <b>Eu-MOF</b>, synthesized via a solvothermal method, exhibits excellent stability, a high surface area, and selective fluorescence quenching upon interaction with salicylaldehyde. The limit of detection was determined to be 7.1 ppm, with minimal interference from other aromatic aldehydes. Mechanistic investigations revealed that fluorescence quenching occurs due to Schiff base formation between salicylaldehyde and amine groups of <b>Eu-MOF</b>. These findings highlight the potential of <b>Eu-MOF</b> as an effective tool for selective and efficient environmental monitoring.</p>","PeriodicalId":34,"journal":{"name":"Crystal Growth & Design","volume":"25 8","pages":"2596–2601 2596–2601"},"PeriodicalIF":3.2,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143832810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular Beam Epitaxy of Mn2In2Se5 van der Waals Layers Using Mn Intercalation","authors":"Qihua Zhang*,&nbsp;Ke Wang,&nbsp;Wesley Auker,&nbsp;Maria Hilse and Stephanie Law*,&nbsp;","doi":"10.1021/acs.cgd.4c0170310.1021/acs.cgd.4c01703","DOIUrl":"https://doi.org/10.1021/acs.cgd.4c01703https://doi.org/10.1021/acs.cgd.4c01703","url":null,"abstract":"<p >The weak van der Waals (vdW) force in layered chalcogenide materials has enabled the growth of ternary chalcogenide layers using unconventional approaches. Here, we report the molecular beam epitaxy (MBE) growth of Mn₂In₂Se_5, a spin glass material with a high level of magnetic frustration, through the heterointegration of MnSe on In₂Se₃. Directly depositing α-MnSe on the vdW In₂Se₃ layers results in Mn intercalation, transforming the In₂Se₃ layer into Mn₂In₂Se₅. Large growth windows, including substrate temperatures from 250 to 450 °C and Se:Mn flux ratios of 1.1–3.1, have been identified for the intercalation process. With an optimized MnSe deposition time, smooth, single-crystalline, and (0001)-oriented Mn₂In₂Se₅ layers with a root-mean-square roughness of 1.5 nm can be synthesized. Further extending the MnSe deposition time results in the growth of uniform rock-salt structured α-MnSe(111) layers with a thickness of up to 8 nm and a narrow full width at half-maximum of 0.35° in MnSe(222) XRD rocking curves. This report presents a unique approach for the growth of uniform and single-crystalline Mn₂In₂Se₅ vdW layers using MBE and potentially opens a pathway for synthesis of ternary vdW chalcogenides by intercalation of new atomic species in binary vdW chalcogenides.</p>","PeriodicalId":34,"journal":{"name":"Crystal Growth & Design","volume":"25 8","pages":"2476–2483 2476–2483"},"PeriodicalIF":3.2,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143832797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-Transmittance Nb-Doped Vanadium Dioxide Thin Films: Crystal Structure Evolution and Thermochromic Characteristics","authors":"Zhijie Deng,&nbsp;Xinguo Ma*,&nbsp;Youyou Guo,&nbsp;Changcun Han* and Mian Jiang,&nbsp;","doi":"10.1021/acs.cgd.5c0003910.1021/acs.cgd.5c00039","DOIUrl":"https://doi.org/10.1021/acs.cgd.5c00039https://doi.org/10.1021/acs.cgd.5c00039","url":null,"abstract":"<p >Utilizing VO₂ thermochromic materials to construct smart energy-saving windows is an arduous point in current science research. Herein, the polymer-assisted solution method prepared ultrathin Nb-doped VO₂ films with diverse doping concentrations. Subsequently, an examination was carried out to investigate the crystal structure, and first-principles further explored the mechanism underlying the reduction of the phase transition temperature (<i>T</i>_c). The results suggest that the electronic doping and strain effects caused by adding Nb ions in the VO₂ crystal lattice cause a decline in the phase transition temperature and a growth in the optical properties. Upon the amount of Nb doping attaining 6 atom %, the <i>T</i>_c of the VO₂ films becomes 28.5 °C, approaching room temperature. Meanwhile, the maximum transmittance in the visible region (<i>T</i>_vis) is 70.1%, and the direct sunlight transmittance (<i>T</i>_sol) is 60.6%. The morphology test showed that the prepared films are well-crystallized. XPS spectral analysis reveals the relationship between the V-ion valence transition by doping Nb and the crystal phase transition. First-principles calculations show that the addition of Nb ions changes the original bond length of the crystal and triggers lattice distortion of intrinsic VO₂. The band gap of monoclinic crystalline VO₂ is lessened. The formation energies of the two crystallographic systems before doping are larger. The formation energy difference is reduced upon doping, and <i>T</i>_c is further reduced. These results are consistent with the experimental results. The high performance of the films illustrates their great possibilities for application in the domain of optical thin films.</p>","PeriodicalId":34,"journal":{"name":"Crystal Growth & Design","volume":"25 8","pages":"2518–2528 2518–2528"},"PeriodicalIF":3.2,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143832661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dual Shielding Balanced Stable Photoluminescence and High Photoresponsivity in MAPbX3–MAPbBrnX3–n@PbBr(OH) Core–Shell Single Crystals","authors":"Kai Liu,&nbsp;Qingyi Zhang,&nbsp;Chengwei Wang,&nbsp;Lei Wang and Feng Chen*,&nbsp;","doi":"10.1021/acs.cgd.5c0004710.1021/acs.cgd.5c00047","DOIUrl":"https://doi.org/10.1021/acs.cgd.5c00047https://doi.org/10.1021/acs.cgd.5c00047","url":null,"abstract":"<p >Organic–inorganic lead halide perovskite (MAPbX₃, X = Cl, Br, I) single crystals exhibit superior optoelectrical and physical characteristics and have been developed in various optical and electrical applications. However, the poor stability against moisture and light remains the most critical demerit of perovskite materials. In this work, light- and waterproof MAPbBr₃-MAPbBr₃@PbBr(OH) core–shell single crystals were successfully synthesized by surface engineering-induced transformation from MAPbBr₃ to MAPbBr₃@PbBr(OH). In addition, an in situ electrode preparation method was developed to construct the Ag/MAPbBr₃-MAPbBr₃@PbBr(OH)/Ag structure during the crystal growing process. The thickness-adjustable MAPbBr₃@PbBr(OH) shell can present dual shielding effects and not only sustains the MAPbBr₃ single crystal core with the highest responsivity of 31 mA W^1–, response time ∼47 ms, and a detection rate of 4.8 × 10¹¹ Jones but also achieves the embedded MAPbBr₃ nanocrystal with bright photoluminescence (quantum yield of 56.1%). Moreover, the similar MAPbCl₃-MAPbBr_<i>n</i>Cl_3–<i>n</i>@PbBr(OH) and MAPbI₃-MAPbBr_<i>n</i>I_3–<i>n</i>@PbBr(OH) core–shell single crystals have been prepared, which also exhibit excellent photoresponsivity and high emission. This work provides an effective strategy for the fabrication of high-performance and environmentally stable photodetectors.</p>","PeriodicalId":34,"journal":{"name":"Crystal Growth & Design","volume":"25 8","pages":"2552–2560 2552–2560"},"PeriodicalIF":3.2,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143832550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Zr(IV) Metal–Organic Framework for Fluorometric Detection of Pesticide Imidacloprid and Anticonvulsant Drug Carbamazepine in Environmental Water and Biological Fluids","authors":"Nazir Ud Din Mir,&nbsp;Ujjwal Kumar and Shyam Biswas*,&nbsp;","doi":"10.1021/acs.cgd.5c0004510.1021/acs.cgd.5c00045","DOIUrl":"https://doi.org/10.1021/acs.cgd.5c00045https://doi.org/10.1021/acs.cgd.5c00045","url":null,"abstract":"<p >In today’s world, food security and safety are growing concerns. Various insecticides, medications, and fertilizer additives are used to harvest foodstuffs. Some of these are extremely harmful to both humans and the environment. Consequently, it is essential to know their existence in food and environmental water and measure their concentrations. A furan-2-carboxamide functionalized, reusable, nanoscale, and sustainable Zr(IV) metal–organic framework (MOF) named <b>1</b> was developed here to address these kinds of problems. The porous framework (<i>S</i>_BET = 609 m² g^–1) was synthesized, characterized, and then used for fast and selective fluorescence sensing of the imidacloprid pesticide and the widely used anticonvulsant drug carbamazepine in the aqueous medium through turn-off fluorescence responses, with a limit of detection values of 1.6 and 0.96 nM for imidacloprid and carbamazepine, respectively. It can detect them within a few seconds (5 s) of their addition. These detection limits are lower than those of any previously reported sensors for these analytes. The probe offers high reusability, selectivity, and a very short response time. Moreover, effective sensing of the analytes was achieved in body fluids (carbamazepine), different fruits and vegetables, soil samples (imidacloprid), environmental water, and across various pH levels. A systematic investigation, supported by proper instrumental techniques, was conducted to understand the mechanisms behind both sensing events. The inner filter effect (IFE) was found to be responsible for both imidacloprid and carbamazepine sensing.</p>","PeriodicalId":34,"journal":{"name":"Crystal Growth & Design","volume":"25 8","pages":"2540–2551 2540–2551"},"PeriodicalIF":3.2,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143832577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}