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ACS Medicinal Chemistry Letters最新文献

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B2R-Targeting Radiotracer for PET/MR Imaging of Hepatocellular Carcinoma and Guiding Anti-B2R Therapy 用于肝细胞癌 PET/MR 成像和指导抗 B2R 治疗的 B2R 靶向放射性示踪剂
IF 4.2 3区 医学
ACS Medicinal Chemistry Letters Pub Date : 2024-06-13 DOI: 10.1021/acsmedchemlett.4c00155
Ke Cai, Yunzhu Zhu, Yifan Zheng, Hui Wang, Yinfeng Qian
{"title":"B2R-Targeting Radiotracer for PET/MR Imaging of Hepatocellular Carcinoma and Guiding Anti-B2R Therapy","authors":"Ke Cai, Yunzhu Zhu, Yifan Zheng, Hui Wang, Yinfeng Qian","doi":"10.1021/acsmedchemlett.4c00155","DOIUrl":"https://doi.org/10.1021/acsmedchemlett.4c00155","url":null,"abstract":"","PeriodicalId":20,"journal":{"name":"ACS Medicinal Chemistry Letters","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2024-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141348610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis and Biological Analysis of Iso-dimethyltryptamines in a Model of Light-Induced Retinal Degeneration 异二甲基色胺在光诱导视网膜变性模型中的合成与生物学分析
IF 4.2 3区 医学
ACS Medicinal Chemistry Letters Pub Date : 2024-06-13 DOI: 10.1021/acsmedchemlett.4c00130
Ethan J. Pazur, Anna Kalatanova, N. Tasker, Katri Vainionpää, Henri Leinonen, Peter Wipf
{"title":"Synthesis and Biological Analysis of Iso-dimethyltryptamines in a Model of Light-Induced Retinal Degeneration","authors":"Ethan J. Pazur, Anna Kalatanova, N. Tasker, Katri Vainionpää, Henri Leinonen, Peter Wipf","doi":"10.1021/acsmedchemlett.4c00130","DOIUrl":"https://doi.org/10.1021/acsmedchemlett.4c00130","url":null,"abstract":"","PeriodicalId":20,"journal":{"name":"ACS Medicinal Chemistry Letters","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2024-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141346511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Optimization of Novel Pyrido-pyridazinone Derivatives as FER Tyrosine Kinase Inhibitors, Leading to the Potent DS08701581 优化作为 FER 酪氨酸激酶抑制剂的新型吡啶并哒嗪酮衍生物，开发出强效 DS08701581
IF 4.2 3区 医学
ACS Medicinal Chemistry Letters Pub Date : 2024-06-13 DOI: 10.1021/acsmedchemlett.4c00030
Toru Taniguchi, Isao Yasumatsu, Hiroaki Inagaki, Daichi Baba, Akiko Toyota, Yasuyuki Kaneta, T. Odagiri, Takayuki Momose, J. Kawai, T. Imaoka, Kiyoshi Nakayama
{"title":"Optimization of Novel Pyrido-pyridazinone Derivatives as FER Tyrosine Kinase Inhibitors, Leading to the Potent DS08701581","authors":"Toru Taniguchi, Isao Yasumatsu, Hiroaki Inagaki, Daichi Baba, Akiko Toyota, Yasuyuki Kaneta, T. Odagiri, Takayuki Momose, J. Kawai, T. Imaoka, Kiyoshi Nakayama","doi":"10.1021/acsmedchemlett.4c00030","DOIUrl":"https://doi.org/10.1021/acsmedchemlett.4c00030","url":null,"abstract":"","PeriodicalId":20,"journal":{"name":"ACS Medicinal Chemistry Letters","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2024-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141346227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In This Issue, Volume 15, Issue 6 本期，第 15 卷第 6 期
IF 4.2 3区 医学
ACS Medicinal Chemistry Letters Pub Date : 2024-06-13 DOI: 10.1021/acsmedchemlett.4c00224
John G. Woodland*, 
{"title":"In This Issue, Volume 15, Issue 6","authors":"John G. Woodland*, ","doi":"10.1021/acsmedchemlett.4c00224","DOIUrl":"https://doi.org/10.1021/acsmedchemlett.4c00224","url":null,"abstract":"","PeriodicalId":20,"journal":{"name":"ACS Medicinal Chemistry Letters","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2024-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141312836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Design, Synthesis, and Evaluation of a New Chemotype Fluorescent Ligand for the P2Y2 Receptor P2Y2 受体新化学型荧光配体的设计、合成和评估
IF 4.2 3区 医学
ACS Medicinal Chemistry Letters Pub Date : 2024-06-12 DOI: 10.1021/acsmedchemlett.4c00211
Rebecca Knight, Laura E. Kilpatrick, Stephen J. Hill, Michael J. Stocks
{"title":"Design, Synthesis, and Evaluation of a New Chemotype Fluorescent Ligand for the P2Y2 Receptor","authors":"Rebecca Knight, Laura E. Kilpatrick, Stephen J. Hill, Michael J. Stocks","doi":"10.1021/acsmedchemlett.4c00211","DOIUrl":"https://doi.org/10.1021/acsmedchemlett.4c00211","url":null,"abstract":"","PeriodicalId":20,"journal":{"name":"ACS Medicinal Chemistry Letters","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2024-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141353318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Investigation of Isobactin Analogues of Teixobactin 研究 Teixobactin 的异菌素类似物
IF 4.2 3区 医学
ACS Medicinal Chemistry Letters Pub Date : 2024-06-11 DOI: 10.1021/acsmedchemlett.4c00215
Chelsea R. Jones, Grant H. Lai, Maria Sophia Teresa Lee Padilla, J. Nowick
{"title":"Investigation of Isobactin Analogues of Teixobactin","authors":"Chelsea R. Jones, Grant H. Lai, Maria Sophia Teresa Lee Padilla, J. Nowick","doi":"10.1021/acsmedchemlett.4c00215","DOIUrl":"https://doi.org/10.1021/acsmedchemlett.4c00215","url":null,"abstract":"","PeriodicalId":20,"journal":{"name":"ACS Medicinal Chemistry Letters","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2024-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141358836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fragment-Based Discovery of Novel MUS81 Inhibitors 基于片段发现新型 MUS81 抑制剂
IF 4.2 3区 医学
ACS Medicinal Chemistry Letters Pub Date : 2024-06-07 DOI: 10.1021/acsmedchemlett.3c00453
G. Collie, U. Börjesson, Yunhua Chen, Zhiqiang Dong, Paolo Di Fruscia, Andrea Gohlke, Anna Hoyle, Thomas A. Hunt, M. Jesani, Haiou Luo, Jakub Luptak, Alexander G. Milbradt, Priyanka Narasimhan, Martin J. Packer, Saleha Patel, Jingchuan Qiao, R. Storer, Christopher J. Stubbs, Jonathan Tart, C. Truman, Anderson T. Wang, Matthew G. Wheeler, J. Winter-Holt
{"title":"Fragment-Based Discovery of Novel MUS81 Inhibitors","authors":"G. Collie, U. Börjesson, Yunhua Chen, Zhiqiang Dong, Paolo Di Fruscia, Andrea Gohlke, Anna Hoyle, Thomas A. Hunt, M. Jesani, Haiou Luo, Jakub Luptak, Alexander G. Milbradt, Priyanka Narasimhan, Martin J. Packer, Saleha Patel, Jingchuan Qiao, R. Storer, Christopher J. Stubbs, Jonathan Tart, C. Truman, Anderson T. Wang, Matthew G. Wheeler, J. Winter-Holt","doi":"10.1021/acsmedchemlett.3c00453","DOIUrl":"https://doi.org/10.1021/acsmedchemlett.3c00453","url":null,"abstract":"","PeriodicalId":20,"journal":{"name":"ACS Medicinal Chemistry Letters","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2024-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141371453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
New Lipophilic Hydroxamates as Promising Trypanocidal Agents: Design, Synthesis, SAR, and Conformational Behavior Studies 新型亲脂羟酰胺类药物作为有前途的杀锥虫药物：设计、合成、SAR 和构象行为研究
IF 4.2 3区 医学
ACS Medicinal Chemistry Letters Pub Date : 2024-06-06 DOI: 10.1021/acsmedchemlett.4c00111
George Fytas, Grigoris Zoidis, Antonios Drakopoulos, Martin C. Taylor, John M. Kelly, Alexandra Tsatsaroni, A. Tsotinis
{"title":"New Lipophilic Hydroxamates as Promising Trypanocidal Agents: Design, Synthesis, SAR, and Conformational Behavior Studies","authors":"George Fytas, Grigoris Zoidis, Antonios Drakopoulos, Martin C. Taylor, John M. Kelly, Alexandra Tsatsaroni, A. Tsotinis","doi":"10.1021/acsmedchemlett.4c00111","DOIUrl":"https://doi.org/10.1021/acsmedchemlett.4c00111","url":null,"abstract":"","PeriodicalId":20,"journal":{"name":"ACS Medicinal Chemistry Letters","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2024-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141380886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
FOCUS on NOD2: Advancing IBD Drug Discovery with a User-Informed Machine Learning Framework 聚焦 NOD2：利用用户知情的机器学习框架推进 IBD 药物研发
IF 4.2 3区 医学
ACS Medicinal Chemistry Letters Pub Date : 2024-06-06 DOI: 10.1021/acsmedchemlett.4c00148
Ruhi Choudhary, R. Mahadevan
{"title":"FOCUS on NOD2: Advancing IBD Drug Discovery with a User-Informed Machine Learning Framework","authors":"Ruhi Choudhary, R. Mahadevan","doi":"10.1021/acsmedchemlett.4c00148","DOIUrl":"https://doi.org/10.1021/acsmedchemlett.4c00148","url":null,"abstract":"","PeriodicalId":20,"journal":{"name":"ACS Medicinal Chemistry Letters","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2024-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141377670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
8-l-Cystinyl Bis(1,8-diazaspiro[4.5]decane) as an Orally Bioavailable l-Cystine Crystallization Inhibitor for Cystinuria 8-l-胱氨酰双(1,8-二氮杂螺[4.5]癸烷)作为口服生物可用性胱氨酸结晶抑制剂治疗胱氨酸尿症
IF 4.2 3区 医学
ACS Medicinal Chemistry Letters Pub Date : 2024-06-06 DOI: 10.1021/acsmedchemlett.4c00066
Longqin Hu, Haifa Albanyan, Jeffrey Yang, Yiling Wang, Min Yang, Xiangduan Tan, Xiaodi Zhong, Michael D. Ward, Amrik Sahota
{"title":"8-l-Cystinyl Bis(1,8-diazaspiro[4.5]decane) as an Orally Bioavailable l-Cystine Crystallization Inhibitor for Cystinuria","authors":"Longqin Hu, Haifa Albanyan, Jeffrey Yang, Yiling Wang, Min Yang, Xiangduan Tan, Xiaodi Zhong, Michael D. Ward, Amrik Sahota","doi":"10.1021/acsmedchemlett.4c00066","DOIUrl":"https://doi.org/10.1021/acsmedchemlett.4c00066","url":null,"abstract":"","PeriodicalId":20,"journal":{"name":"ACS Medicinal Chemistry Letters","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2024-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141381301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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