Nano Letters最新文献

Nanomagnetic Guidance Shapes the Structure–Function Relationship of Developing Cortical Networks 纳米磁导向塑造发育中皮质网络的结构-功能关系

IF 10.8 1区材料科学

Nano Letters Pub Date : 2024-10-21 DOI: 10.1021/acs.nanolett.4c03156

Connor L. Beck, Conner T. Killeen, Sara C. Johnson, Anja Kunze

{"title":"Nanomagnetic Guidance Shapes the Structure–Function Relationship of Developing Cortical Networks","authors":"Connor L. Beck, Conner T. Killeen, Sara C. Johnson, Anja Kunze","doi":"10.1021/acs.nanolett.4c03156","DOIUrl":"https://doi.org/10.1021/acs.nanolett.4c03156","url":null,"abstract":"In this study, we implement large-scale nanomagnetic guidance on cortical neurons to guide dissociated neuronal networks during development. Cortical networks cultured over microelectrode arrays were exposed to functionalized magnetic nanoparticles, followed by magnetic field exposure to guide neurites over 14 days in vitro. Immunofluorescence of the axonal protein Tau revealed a greater number of neurites that were longer and aligned with the nanomagnetic force relative to nonguided networks. This was further confirmed through brightfield imaging on the microelectrode arrays during development. Spontaneous electrophysiological recordings revealed that the guided networks exhibited increased firing rates and frequency in force-aligned connectivity identified through Granger Causality. Applying this methodology across networks with nonuniform force directions increased local activity in target regions, identified as regions in the direction of the nanomagnetic force. Altogether, these results demonstrate that nanomagnetic forces guide the structure and function of dissociated cortical neuron networks at the millimeter scale.","PeriodicalId":53,"journal":{"name":"Nano Letters","volume":null,"pages":null},"PeriodicalIF":10.8,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142452101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High-Resolution Distance Dependence Interrogation of Scanning Ion Conductance Microscopic Tip-Enhanced Raman Spectroscopy Enabled by Two-Dimensional Molybdenum Disulfide Substrates 利用二维二硫化钼基底实现扫描离子传导显微镜尖端增强拉曼光谱的高分辨率距离相关性探测

IF 10.8 1区材料科学

Nano Letters Pub Date : 2024-10-21 DOI: 10.1021/acs.nanolett.4c04200

Xing He, Abu Montakim Tareq, Kai Qi, Ylli Conti, Vincent Tung, Naihao Chiang

{"title":"High-Resolution Distance Dependence Interrogation of Scanning Ion Conductance Microscopic Tip-Enhanced Raman Spectroscopy Enabled by Two-Dimensional Molybdenum Disulfide Substrates","authors":"Xing He, Abu Montakim Tareq, Kai Qi, Ylli Conti, Vincent Tung, Naihao Chiang","doi":"10.1021/acs.nanolett.4c04200","DOIUrl":"https://doi.org/10.1021/acs.nanolett.4c04200","url":null,"abstract":"Scanning ion conductance microscopy (SICM) is a powerful surface imaging tool used in the electrolytic environment. Tip-enhanced Raman spectroscopy (TERS) can give more information in addition to the morphology provided by the SICM by utilizing label-free Raman spectroscopy aided by the localized plasmonic enhancement from the metal-coated probes. In this study, the integration of SICM with TERS is demonstrated through employing a silver-coated plasmonic nanopipette. Leveraging a two-dimensional (2D) molybdenum disulfide (MoS2) as a model system, the SICM-TERS enhancement factor was estimated to be ∼105, supported by finite-difference time-domain (FDTD) simulation. Moreover, the subnanometer distance dependence SICM-TERS study reveals the tensile stress and structural changes caused by the nanopipette. These findings illustrate the potential of SICM-TERS for providing comprehensive morphological and chemical insights into electrolytic environments, paving the way for future investigations of electrocatalytic and biological systems.","PeriodicalId":53,"journal":{"name":"Nano Letters","volume":null,"pages":null},"PeriodicalIF":10.8,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142452102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quantitative Analysis of Protein–Protein Equilibrium Constants in Cellular Environments Using Single-Molecule Localization Microscopy 利用单分子定位显微镜定量分析细胞环境中的蛋白质-蛋白质平衡常数

IF 10.8 1区材料科学

Nano Letters Pub Date : 2024-10-21 DOI: 10.1021/acs.nanolett.4c04394

Luis F. Marcano-García, Cecilia Zaza, Olivia P. L. Dalby, Megan D. Joseph, M. Victoria Cappellari, Sabrina Simoncelli, Pedro F. Aramendía

{"title":"Quantitative Analysis of Protein–Protein Equilibrium Constants in Cellular Environments Using Single-Molecule Localization Microscopy","authors":"Luis F. Marcano-García, Cecilia Zaza, Olivia P. L. Dalby, Megan D. Joseph, M. Victoria Cappellari, Sabrina Simoncelli, Pedro F. Aramendía","doi":"10.1021/acs.nanolett.4c04394","DOIUrl":"https://doi.org/10.1021/acs.nanolett.4c04394","url":null,"abstract":"Current methods for determining equilibrium constants often operate in three-dimensional environments, which may not accurately reflect interactions with membrane-bound proteins. With our technique, based on single-molecule localization microscopy (SMLM), we directly determine protein–protein association (Ka) and dissociation (Kd) constants in cellular environments by quantifying associated and isolated molecules and their interaction area. We introduce Kernel Surface Density (ks-density,) a novel method for determining the accessible area for interacting molecules, eliminating the need for user-defined parameters. Simulation studies validate our method’s accuracy across various density and affinity conditions. Applying this technique to T cell signaling proteins, we determine the 2D association constant of T cell receptors (TCRs) in resting cells and the pseudo-3D dissociation constant of pZAP70 molecules from phosphorylated intracellular tyrosine-based activation motifs on the TCR-CD3 complex. We address challenges of multiple detection and molecular labeling efficiency. This method enhances our understanding of protein interactions in cellular environments, advancing our knowledge of complex biological processes.","PeriodicalId":53,"journal":{"name":"Nano Letters","volume":null,"pages":null},"PeriodicalIF":10.8,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142452103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Structure-Guided Bacteria Specificity and Wide Activity Spectrum of Endotoxin-Responsive Peptide Nanonets 内毒素响应肽纳米网的结构引导细菌特异性和广泛活性谱

IF 10.8 1区材料科学

Nano Letters Pub Date : 2024-10-21 DOI: 10.1021/acs.nanolett.4c03166

Nhan Dai Thien Tram, Jan Kazimierz Marzinek, Louis Perrin, Devika Mukherjee, Vanitha Selvarajan, Peter John Bond, Pui Lai Rachel Ee

{"title":"Structure-Guided Bacteria Specificity and Wide Activity Spectrum of Endotoxin-Responsive Peptide Nanonets","authors":"Nhan Dai Thien Tram, Jan Kazimierz Marzinek, Louis Perrin, Devika Mukherjee, Vanitha Selvarajan, Peter John Bond, Pui Lai Rachel Ee","doi":"10.1021/acs.nanolett.4c03166","DOIUrl":"https://doi.org/10.1021/acs.nanolett.4c03166","url":null,"abstract":"Peptide nanonets offer a promising avenue for constructing anti-infective biomaterials. Our group recently reported innovative designs of synthetic BTT nanonets that fibrillate selectively in response to bacterial endotoxins. Herein, we delved deeper into the molecular interactions between our peptides and these bacteria-specific biomolecules, which is an aspect critically missing from major works in the field. Using microscopic and biophysical techniques, we identified phosphate moieties in endotoxins as being the most essential to the initiation of peptide fibrillation. This was strongly supported by molecular dynamics simulations in an outer membrane environment with variable states of phosphorylation. To support the claim over bacterial specificity, we demonstrated a lack of nanonet formation in the presence of various phosphate-containing biomolecules native to human biology. The structural importance of phosphate moieties among pathogenic strains strongly indicates a wide clinical spectrum of our peptides, which was experimentally verified.","PeriodicalId":53,"journal":{"name":"Nano Letters","volume":null,"pages":null},"PeriodicalIF":10.8,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142452121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Salmonella Biomimetic Nanoparticles for Photothermal-Chemotherapy of Colorectal Cancer 用于大肠癌光热化疗的沙门氏菌仿生纳米粒子

IF 10.8 1区材料科学

Nano Letters Pub Date : 2024-10-21 DOI: 10.1021/acs.nanolett.4c04609

Ruichi Liu, Yunqiu Miao, Keyi Wen, Yang Yang, Dan Xu, Shengwei Lu, Ziyuan Liu, Huanlong Qin, Xinxin Zhang, Yang Zhang

{"title":"Salmonella Biomimetic Nanoparticles for Photothermal-Chemotherapy of Colorectal Cancer","authors":"Ruichi Liu, Yunqiu Miao, Keyi Wen, Yang Yang, Dan Xu, Shengwei Lu, Ziyuan Liu, Huanlong Qin, Xinxin Zhang, Yang Zhang","doi":"10.1021/acs.nanolett.4c04609","DOIUrl":"https://doi.org/10.1021/acs.nanolett.4c04609","url":null,"abstract":"Nanomedicines have been widely used in colorectal cancer treatment, but their suboptimal targeting and deficient penetration capabilities remain obstacles in the delivery of therapeutics. In this study, inspired by the natural tumor tropism and intestinal invasion of Salmonella, we engineered highly biomimetic nanoparticles (SM-AuNRs) utilizing a Salmonella membrane to coat bacilliform Au nanorods. The engineered SM-AuNRs were able to mimic the germ’s morphology and biological surface. SM-AuNRs containing the specific proteins inherited from the Salmonella membrane facilitated specific targeting and internalization into tumor cells. Meanwhile, SM-AuNRs with the rod-shaped morphology effectively traversed mucus barriers and tumor stroma. Due to the superior biological barrier penetrating and tumor targeting capabilities, doxorubicin-loaded SM-AuNRs with near-infrared laser irradiation displayed remarkable photothermal-chemotherapeutic antitumor effects in mouse orthotopic colorectal cancer models. Our findings pave the way for the design of bacteria-mimicking nanoparticles, presenting a promising avenue for the targeting and efficient treatment of colorectal cancer.","PeriodicalId":53,"journal":{"name":"Nano Letters","volume":null,"pages":null},"PeriodicalIF":10.8,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142452104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Element-Specific Ultrafast Lattice Dynamics in Monolayer WSe2 单层 WSe2 中特定元素的超快晶格动力学

IF 10.8 1区材料科学

Nano Letters Pub Date : 2024-10-21 DOI: 10.1021/acs.nanolett.4c03611

Hyein Jung, Shuo Dong, Daniela Zahn, Thomas Vasileiadis, Helene Seiler, Robert Schneider, Steffen Michaelis de Vasconcellos, Victoria C. A. Taylor, Rudolf Bratschitsch, Ralph Ernstorfer, Yoav William Windsor

引用次数: 0

Narrowband Electroluminescence from Color Centers in Hexagonal Boron Nitride 六方氮化硼颜色中心的窄带电致发光

IF 10.8 1区材料科学

Nano Letters Pub Date : 2024-10-21 DOI: 10.1021/acs.nanolett.4c03824

Gyuna Park, Ivan Zhigulin, Hoyoung Jung, Jake Horder, Karin Yamamura, Yerin Han, Hyunje Cho, Hyeon-Woo Jeong, Kenji Watanabe, Takashi Taniguchi, Myungchul Oh, Gil-Ho Lee, Moon-Ho Jo, Igor Aharonovich, Jonghwan Kim

{"title":"Narrowband Electroluminescence from Color Centers in Hexagonal Boron Nitride","authors":"Gyuna Park, Ivan Zhigulin, Hoyoung Jung, Jake Horder, Karin Yamamura, Yerin Han, Hyunje Cho, Hyeon-Woo Jeong, Kenji Watanabe, Takashi Taniguchi, Myungchul Oh, Gil-Ho Lee, Moon-Ho Jo, Igor Aharonovich, Jonghwan Kim","doi":"10.1021/acs.nanolett.4c03824","DOIUrl":"https://doi.org/10.1021/acs.nanolett.4c03824","url":null,"abstract":"Defects in wide bandgap materials have emerged as promising candidates for solid-state quantum optical technologies. Electrical excitation of single emitters may lead to scalable on-chip devices and therefore is highly sought after. However, most wide bandgap materials are not amenable to efficient doping, posing challenges for electrical excitation and on-chip integration. Here, we demonstrate narrowband electroluminescence from visible and near-infrared color centers in hexagonal boron nitride (hBN). We harness van der Waals tunnel junctions of graphene–hBN–graphene. Charge carriers are electrically injected into hBN, exciting localized defects that emit nonclassical light, as characterized by the second order correlation measurement. Remarkably, the devices operate at room temperature and produce robust, narrowband emission spanning from visible to the near-infrared. Our work marks an important milestone in vdW materials and their promising attributes for integrated quantum technologies and on-chip photonic circuits.","PeriodicalId":53,"journal":{"name":"Nano Letters","volume":null,"pages":null},"PeriodicalIF":10.8,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142452272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spectrum of Tunneling Transport through Phonon-Coupled Defect States in a Carbon-Doped Hexagonal Boron Nitride Barrier 掺碳六方氮化硼势垒中通过声子耦合缺陷态的隧道传输频谱

IF 10.8 1区材料科学

Nano Letters Pub Date : 2024-10-21 DOI: 10.1021/acs.nanolett.4c03847

Yuta Seo, Yuki Tsuji, Momoko Onodera, Rai Moriya, Yijin Zhang, Kenji Watanabe, Takashi Taniguchi, Tomoki Machida

{"title":"Spectrum of Tunneling Transport through Phonon-Coupled Defect States in a Carbon-Doped Hexagonal Boron Nitride Barrier","authors":"Yuta Seo, Yuki Tsuji, Momoko Onodera, Rai Moriya, Yijin Zhang, Kenji Watanabe, Takashi Taniguchi, Tomoki Machida","doi":"10.1021/acs.nanolett.4c03847","DOIUrl":"https://doi.org/10.1021/acs.nanolett.4c03847","url":null,"abstract":"Defects in hexagonal boron nitride (h-BN) play important roles in tunneling transport through the h-BN barrier. Here, using carbon-doped h-BN (h-BN:C) as a tunnel barrier containing defects in a controlled manner, we investigated tunneling transport through defects in the h-BN:C/graphene heterostructures. Defect-assisted tunneling through a specific kind of carbon-related defect was observed in all measured devices, where the defect level was always located at ∼0.1 eV above the graphene’s charge neutrality point. We revealed a phonon-assisted inelastic process in the defect-assisted tunneling, in which carriers tunnel through the defect with phonon emission. Furthermore, when the h-BN:C barrier was thick (12 layers, ∼4 nm), sequential tunneling through two defects became dominant, where the phonon-assisted inelastic process shows substantial effects between the two defects. This study reveals the contribution of phonons to defect-assisted tunneling transport, which is essential for the development of defect-related van der Waals (vdW) electronic techniques.","PeriodicalId":53,"journal":{"name":"Nano Letters","volume":null,"pages":null},"PeriodicalIF":10.8,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142452273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gate-Controlled Potassium Intercalation and Superconductivity in Molybdenum Disulfide 二硫化钼中的栅极控制钾互锁和超导性

IF 10.8 1区材料科学

Nano Letters Pub Date : 2024-10-21 DOI: 10.1021/acs.nanolett.4c04134

Ricky Dwi Septianto, Alec Paul Romagosa, Yu Dong, Hideki Matsuoka, Toshiya Ideue, Yutaka Majima, Yoshihiro Iwasa

{"title":"Gate-Controlled Potassium Intercalation and Superconductivity in Molybdenum Disulfide","authors":"Ricky Dwi Septianto, Alec Paul Romagosa, Yu Dong, Hideki Matsuoka, Toshiya Ideue, Yutaka Majima, Yoshihiro Iwasa","doi":"10.1021/acs.nanolett.4c04134","DOIUrl":"https://doi.org/10.1021/acs.nanolett.4c04134","url":null,"abstract":"Intercalation of guest ions into a van der Waals (vdW) gap in layered materials is a powerful route to create novel material phases and functionalities. Ionic gating is a technique to control the motions and configuration of ions for both intercalation and surface electrostatic doping. The advance of ionic gating enables the in situ probe of dynamics of ion diffusion, carrier doping, and transport properties. Here we performed in situ resistivity and Raman experiments on the potassium ion (K+) intercalation of single-crystal MoS2 and constructed a temperature–carrier density phase diagram. The K+-intercalation induces a structural transition from the prismatically coordinated phase to the octahedrally coordinated phase, where anisotropic three-dimensional superconductivity and a possible charge density wave state were observed. The present ionic gating offers a comprehensive view of the intercalated phases and proves that the electrostatically induced superconductivity is distinct from that in the intercalated phase.","PeriodicalId":53,"journal":{"name":"Nano Letters","volume":null,"pages":null},"PeriodicalIF":10.8,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142452274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mesoporous Silica Supported Hydrophilic Ionic Liquid Gel Microspheres for Solvent-Free Deep Oxidative Desulfurization 用于无溶剂深度氧化脱硫的介孔二氧化硅亲水离子液体凝胶微球

IF 10.8 1区材料科学

Nano Letters Pub Date : 2024-10-21 DOI: 10.1021/acs.nanolett.4c03345

Dongqing He, Dezhou Cao, Yuanxiang You, Chuxuan Ben, Shuyao Wu, Qiong Wu, Daliang Liu, Xi-Ming Song, Zhining Song, Qing Bo Meng

{"title":"Mesoporous Silica Supported Hydrophilic Ionic Liquid Gel Microspheres for Solvent-Free Deep Oxidative Desulfurization","authors":"Dongqing He, Dezhou Cao, Yuanxiang You, Chuxuan Ben, Shuyao Wu, Qiong Wu, Daliang Liu, Xi-Ming Song, Zhining Song, Qing Bo Meng","doi":"10.1021/acs.nanolett.4c03345","DOIUrl":"https://doi.org/10.1021/acs.nanolett.4c03345","url":null,"abstract":"Solvent-free oxidative desulfurization can avoid environmental pollution caused by organic solvents as well as prevent loss of fuel during the oil–water separation process. In this work, first, hydrophilic ionic liquid gel microspheres with [BMIM]BF4 and PHEMA as the dispersion medium and gel network, respectively, were successfully prepared by using mesoporous silica microspheres as a supporting skeleton capable of stabilizing the gel through an anchoring effect, and then the catalyst [BMIM]PW and oxidant H2O2 were incorporated into the gel microspheres to construct a liquid compartment microreactor for deep desulfurization. The prepared microreactor (SiO2@[BMIM]PW/ILG-microspheres) has excellent extraction–catalytic capacity and exhibited ∼100% desulfurization ratio for a model oil of n-heptane with 500 ppm of DBT at 60 °C for 3 h without solvents. Additionally, the prepared microreactor can absorb hydrophilic desulfurization products after the reaction and has advantages of reusability and simple recovery without polluting the fuel oil, which is beneficial for potential petroleum industrial application.","PeriodicalId":53,"journal":{"name":"Nano Letters","volume":null,"pages":null},"PeriodicalIF":10.8,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142452270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0