Nano Letters最新文献

Attonewton Force Resolution Measurements with Silicon Nanospheres at the Thermal Noise Limit in Ambient-Temperature Liquids. 室温液体中热噪声极限下硅纳米球的牛顿力分辨率测量。

IF 10.8 1区材料科学

Nano Letters Pub Date : 2025-08-05 DOI: 10.1021/acs.nanolett.5c02698

Aleksandr Kostarev,Mohammad K Abdosamadi,Hiroshi Sugimoto,Minoru Fujii,Anita Jannasch,Erik Schäffer

{"title":"Attonewton Force Resolution Measurements with Silicon Nanospheres at the Thermal Noise Limit in Ambient-Temperature Liquids.","authors":"Aleksandr Kostarev,Mohammad K Abdosamadi,Hiroshi Sugimoto,Minoru Fujii,Anita Jannasch,Erik Schäffer","doi":"10.1021/acs.nanolett.5c02698","DOIUrl":"https://doi.org/10.1021/acs.nanolett.5c02698","url":null,"abstract":"Precise force measurements are crucial for understanding fundamental physics or nanoscale interactions, such as those of molecular machines in biology. Optical tweezers are versatile force transducers for such measurements, enabling meticulous manipulation of small particles. However, achieving high-resolution, subfemtonewton force measurements under physiological conditions remains challenging due to thermal fluctuations and instrument noise. Here, we employed an ultrastable optical tweezers setup in an isolated environment with precise temperature control, which minimized instrumental noise and enabled prolonged, low-force measurements. We utilized water-suspended, high-refractive index silicon nanospheres for improved resolution and trapping stability. Our system achieved a force resolution of ≈60 aN, with a sensitivity of 2.7 fN Hz-0.5, allowing us to measure forces as low as 0.30 ± 0.06 fN. Our drag force measurements demonstrate the importance of optimized experimental conditions for low-force measurements, providing a robust framework for scientific investigations that require high-precision force characterization.","PeriodicalId":53,"journal":{"name":"Nano Letters","volume":"16 1","pages":""},"PeriodicalIF":10.8,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144778079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ion-Dipole Interaction Driven Alumina-Coated Polyethylene Separator with Enhanced Wettability for High-Performance Rechargeable Aluminum Batteries. 离子偶极相互作用驱动的高性能可充电铝电池润湿性增强的氧化铝涂层聚乙烯分离器。

IF 10.8 1区材料科学

Nano Letters Pub Date : 2025-08-05 DOI: 10.1021/acs.nanolett.5c02955

Nashaat Ahmed,Dmitrii A Rakov,Yang Liu,Jiayou Feng,Shuimei Chen,Yuzheng Wu,Yongle Cheng,Ashok Nanjundan Kumar,Chengzhong Yu,Xiaodan Huang

{"title":"Ion-Dipole Interaction Driven Alumina-Coated Polyethylene Separator with Enhanced Wettability for High-Performance Rechargeable Aluminum Batteries.","authors":"Nashaat Ahmed,Dmitrii A Rakov,Yang Liu,Jiayou Feng,Shuimei Chen,Yuzheng Wu,Yongle Cheng,Ashok Nanjundan Kumar,Chengzhong Yu,Xiaodan Huang","doi":"10.1021/acs.nanolett.5c02955","DOIUrl":"https://doi.org/10.1021/acs.nanolett.5c02955","url":null,"abstract":"Separators are essential for safe and efficient battery operation. Polyolefin separators like polyethylene (PE) are widely used in lithium-ion batteries but are incompatible with strongly polar electrolytes, such as chloroaluminate ionic liquids in rechargeable aluminum batteries (RABs). Glass fiber (GF) membranes are commonly used in RABs due to good wettability, but their excessive thickness, mechanical fragility, and nonuniform macropores limit practicality. This study investigates the feasibility of utilizing an alumina-coated PE (Al2O3-PE) separator for RABs. Theoretical and experimental analyses show that the polarizable Al2O3 induces strong ion-dipole interactions with RAB electrolytes, imparting exceptional wettability and electrolyte uptake. Combined with its uniform nanopore structure, Al2O3-PE enables homogeneous ion flux for reversible Al stripping/plating with dendrite suppression. In RABs with graphene cathodes, Al2O3-PE outperforms GF separators, achieving higher capacity, improved rate performance, and long cycling stability. Flexible pouch cells with Al2O3-PE demonstrate stable operation under bending, supporting practical application.","PeriodicalId":53,"journal":{"name":"Nano Letters","volume":"8 1","pages":""},"PeriodicalIF":10.8,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144778117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Design of Mott Multiferroic HfO2 by Inducing Unpaired d States. 利用诱导非配对d态设计Mott多铁HfO2。

IF 10.8 1区材料科学

Nano Letters Pub Date : 2025-08-05 DOI: 10.1021/acs.nanolett.5c02825

Guanwen Yao,Ming Yu,Xiaoyan Liu,Jinfeng Kang,Fei Liu

引用次数: 0

Optical Activity Modulation in Chiral Metasurfaces via Structured Light. 通过结构光调制手性超表面的光学活性。

IF 10.8 1区材料科学

Nano Letters Pub Date : 2025-08-05 DOI: 10.1021/acs.nanolett.5c03044

Paula L Lalaguna,Shun Hashiyada,Nikolaj Gadegaard,Jörg B Götte,Stephen M Barnett,Kayn A Forbes,Yoshito Y Tanaka,Malcolm Kadodwala

引用次数: 0

Hydrogel-Based Sequential Photodynamic Therapy Promotes Wound Healing by Targeting Wound Infection and Inflammation. 基于水凝胶的顺序光动力疗法通过靶向伤口感染和炎症促进伤口愈合。

IF 10.8 1区材料科学

Nano Letters Pub Date : 2025-08-05 DOI: 10.1021/acs.nanolett.5c00014

Haohuan Li,Hailong Xie,Jiaman Zhang,Chuang Tang,Shibo Tian,Peng Yuan,Chenglu Sun,Chao Cui,Qin Zhong,Funeng Xu,Xiao-Xia Liang,Hualin Fu,Long Jin,Keren Long,Lu Lu,Xun Zhou,Jiaxue Cao,Jianlin Yuan,Juan Deng,Dengfeng Gao,Bo Huang,Mingzhou Li

{"title":"Hydrogel-Based Sequential Photodynamic Therapy Promotes Wound Healing by Targeting Wound Infection and Inflammation.","authors":"Haohuan Li,Hailong Xie,Jiaman Zhang,Chuang Tang,Shibo Tian,Peng Yuan,Chenglu Sun,Chao Cui,Qin Zhong,Funeng Xu,Xiao-Xia Liang,Hualin Fu,Long Jin,Keren Long,Lu Lu,Xun Zhou,Jiaxue Cao,Jianlin Yuan,Juan Deng,Dengfeng Gao,Bo Huang,Mingzhou Li","doi":"10.1021/acs.nanolett.5c00014","DOIUrl":"https://doi.org/10.1021/acs.nanolett.5c00014","url":null,"abstract":"Impaired wound healing remains a significant clinical challenge, often exacerbated by bacterial infections and persistent inflammation. Photodynamic therapy (PDT) has demonstrated efficacy in combating bacterial infections; however, its utility in wound healing is limited due to its inability to address inflammation. To overcome this limitation, we have developed a PDT-based sequential therapy. Our approach effectively eliminates bacteria by generating sufficient reactive oxygen species and nitric oxide (NO). It subsequently mitigates inflammation through sustained NO release and oxygen delivery. Additionally, we incorporated a pH-sensitive indicator to enable a sequential therapeutic schedule, optimizing the timing of antibacterial and anti-inflammatory interventions during wound healing. We demonstrate that this therapy enhances anti-infection efficacy, alleviates wound inflammation, and fosters a supportive environment for skin and superficial skeletal muscle repair in mouse, rabbit, and pig models. Collectively, our findings highlight the transformative potential of this strategy for advancing PDT in the treatment of wound healing.","PeriodicalId":53,"journal":{"name":"Nano Letters","volume":"11 1","pages":""},"PeriodicalIF":10.8,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144778081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Precision Mapping of Direct Membrane Protein Interactions via Binding-Induced DNA Barcode Transfer Labeling. 通过结合诱导的DNA条形码转移标记精确定位膜蛋白直接相互作用。

IF 10.8 1区材料科学

Nano Letters Pub Date : 2025-08-04 DOI: 10.1021/acs.nanolett.5c03014

Weikang Li,Xigao Chen,Nachuan Wen,Zhongchao Chen,Weihong Yang,Wenfei Guo,Qiang Zhang,Zhaoyang Wang,Xiaoman Zhai,Liping Qiu,Weihong Tan

{"title":"Precision Mapping of Direct Membrane Protein Interactions via Binding-Induced DNA Barcode Transfer Labeling.","authors":"Weikang Li,Xigao Chen,Nachuan Wen,Zhongchao Chen,Weihong Yang,Wenfei Guo,Qiang Zhang,Zhaoyang Wang,Xiaoman Zhai,Liping Qiu,Weihong Tan","doi":"10.1021/acs.nanolett.5c03014","DOIUrl":"https://doi.org/10.1021/acs.nanolett.5c03014","url":null,"abstract":"Cell-cell communication is governed by dynamic membrane protein interactions. Precise tracking of direct protein binding and its functional outcomes across cellular engagements is essential for decoding complex biological processes. While proximity-based labeling techniques convert transient interactions into stable signals, they often fail to distinguish direct binding from nonspecific associations. In this work, we developed a binding-induced labeling strategy for 1:1 DNA barcode transfer between interacting proteins at the cellular interface. Using the PD1/PD-L1 immune checkpoint as a model, we designed functionalized aptamer probes targeting PD-L1 on cancer cells, which upon PD1/PD-L1 binding were covalently transferred to PD1 on T cells via click chemistry. By incorporating barcoded primer sequences and programmable DNA signal amplification, we achieved sensitive and sequential tracking of individual PD1/PD-L1 binding events across multiple cellular interactions. Furthermore, with the integration of single-cell transcriptional profiling, this platform revealed the progressive impact of iterative PD1/PD-L1 binding on T-cell reprogramming.","PeriodicalId":53,"journal":{"name":"Nano Letters","volume":"15 1","pages":""},"PeriodicalIF":10.8,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144769625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Surface Tip Effects Enhanced Performance of Proton Exchange Membrane Water Electrolyzers. 表面尖端效应增强质子交换膜水电解槽性能。

IF 10.8 1区材料科学

Nano Letters Pub Date : 2025-08-04 DOI: 10.1021/acs.nanolett.5c02984

Bingqian Pang,Yun Liu,Lutong Shan,Wenjuan Shi,Hui Chen,Suyang Feng,Peng Rao,Jing Li,Tianjiao Wang,Xiaodong Shi,Xue Bai,Gaoqiang Yang,Xinlong Tian,Zhenye Kang

引用次数: 0

Programmable RNA Nanostructures Enable Nanopore Detection of Cotranscriptionally Introduced RNA Modifications. 可编程RNA纳米结构使纳米孔检测共转录引入的RNA修饰。

IF 10.8 1区材料科学

Nano Letters Pub Date : 2025-08-04 DOI: 10.1021/acs.nanolett.5c02391

Iva Mohora,Gerardo Patiño Guillén,Kevin Neis,Julián Valero,Ulrich F Keyser,Filip Bošković

{"title":"Programmable RNA Nanostructures Enable Nanopore Detection of Cotranscriptionally Introduced RNA Modifications.","authors":"Iva Mohora,Gerardo Patiño Guillén,Kevin Neis,Julián Valero,Ulrich F Keyser,Filip Bošković","doi":"10.1021/acs.nanolett.5c02391","DOIUrl":"https://doi.org/10.1021/acs.nanolett.5c02391","url":null,"abstract":"Tracking RNA synthesis and metabolic histories requires cotranscriptional incorporation of modified nucleotides. However, identifying the incorporation of modified nucleotides into nascent RNA remains challenging, particularly for short RNAs. In this work, we developed a method utilizing solid-state nanopores and DNA:RNA nanostructures to detect modified nucleotide incorporation across different RNA length scales, from short to long RNAs transcribed in vitro. We identified the incorporation of biotin-modified uridine in short RNAs using a DNA nanostructure coupled with a nanopore readout. As a proof of concept for tracking RNA synthesis, we evaluated the incorporation of azide-modified uridine into long RNAs. To achieve quantitative labeling, we optimized conditions for click chemistry using cyclooctyne-DNA oligonucleotides. Subsequently, we successfully decorated long RNAs with azide-modified uridine and quantified the relative incorporation levels using nanopores. Our study establishes a robust platform for solid-state nanopore characterization of modified nucleotide-containing RNAs, advancing single-molecule analyses of RNA dynamics.","PeriodicalId":53,"journal":{"name":"Nano Letters","volume":"13 1","pages":""},"PeriodicalIF":10.8,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144769631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gradient Nitrogen-Doped Memristor for Computing-in-Memory. 用于内存计算的梯度氮掺杂忆阻器。

IF 9.1 1区材料科学

Nano Letters Pub Date : 2025-08-04 DOI: 10.1021/acs.nanolett.5c03050

Menglan Li, Yangyu Dong, Jiamin Tian, Yifan Jiang, Xinyue Li, Shuo Li, Bingjie Wang, Xuan Li, Shimin Hou, Qing Chen

{"title":"Gradient Nitrogen-Doped Memristor for Computing-in-Memory.","authors":"Menglan Li, Yangyu Dong, Jiamin Tian, Yifan Jiang, Xinyue Li, Shuo Li, Bingjie Wang, Xuan Li, Shimin Hou, Qing Chen","doi":"10.1021/acs.nanolett.5c03050","DOIUrl":"https://doi.org/10.1021/acs.nanolett.5c03050","url":null,"abstract":"Oxide-based memristors hold promise for computing-in-memory (CIM) architectures due to their compatibility with complementary metal-oxide-semiconductor processes. However, the intrinsically nonuniform growth rates and stochastic formation pathways of conductive filaments (CFs) degrade conductance modulation linearity and cycle-to-cycle uniformity, thereby hindering their application in reliable CIM systems. Here, we propose a simple approach to simultaneously improve the linearity and uniformity of HfOx memristors through gradient nitrogen-doping (GND). This doping strategy establishes a stair-like energy barrier profile for oxygen ion migration, effectively regulating the growth rate of CFs and thereby enhancing linearity. Concurrently, nitrogen dopants confine CF growth along the same pathways during repeated cycles, thereby achieving ultrasmall switching voltage variation (3.1%) and resistance variation (5.7%). Furthermore, by successfully executing stateful Boolean logic and implementing long short-term memory network cores in GND memristor arrays for high-accuracy temporal sequence prediction tasks, the GND memristor demonstrates its versatility in both digital and analog CIM systems.","PeriodicalId":53,"journal":{"name":"Nano Letters","volume":" ","pages":""},"PeriodicalIF":9.1,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144774333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anisotropic High Carrier Mobility in Violet Phosphorus. 紫磷中各向异性高载流子迁移率。

IF 10.8 1区材料科学

Nano Letters Pub Date : 2025-08-04 DOI: 10.1021/acs.nanolett.5c03034

Yuanyuan Zheng,Cong Wang,Yubo Tian,Xinyu Wang,Chuanxiu Jiang,Yuyang Zhang,Yiyang Gong,Yangguang Zhong,Shaoli Wang,Shuai Yue,Xinfeng Liu

引用次数: 0