IF 5.9 2区医学

Neural Regeneration Research Pub Date : 2025-08-01 Epub Date: 2024-09-06 DOI: 10.4103/NRR.NRR-D-23-01231

Krisztián Pajer, Tamás Bellák, Antal Nógrádi

引用次数: 0

Impact of Zika virus non-structural protein mutations on hippocampal damage. 寨卡病毒非结构蛋白突变对海马损伤的影响

IF 5.9 2区医学

Neural Regeneration Research Pub Date : 2025-08-01 Epub Date: 2024-07-29 DOI: 10.4103/NRR.NRR-D-24-00493

Larissa M G Cassiano, Roney S Coimbra

引用次数: 0

Utilizing engineered extracellular vesicles as delivery vectors in the management of ischemic stroke: a special outlook on mitochondrial delivery. 利用工程细胞外囊泡作为输送载体治疗缺血性中风：线粒体输送的特殊前景。

IF 5.9 2区医学

Neural Regeneration Research Pub Date : 2025-08-01 Epub Date: 2024-07-29 DOI: 10.4103/NRR.NRR-D-24-00243

Jiali Chen, Yiyang Li, Xingping Quan, Jinfen Chen, Yan Han, Li Yang, Manfei Zhou, Greta Seng Peng Mok, Ruibing Wang, Yonghua Zhao

{"title":"Utilizing engineered extracellular vesicles as delivery vectors in the management of ischemic stroke: a special outlook on mitochondrial delivery.","authors":"Jiali Chen, Yiyang Li, Xingping Quan, Jinfen Chen, Yan Han, Li Yang, Manfei Zhou, Greta Seng Peng Mok, Ruibing Wang, Yonghua Zhao","doi":"10.4103/NRR.NRR-D-24-00243","DOIUrl":"10.4103/NRR.NRR-D-24-00243","url":null,"abstract":"Ischemic stroke is a secondary cause of mortality worldwide, imposing considerable medical and economic burdens on society. Extracellular vesicles, serving as natural nano-carriers for drug delivery, exhibit excellent biocompatibility in vivo and have significant advantages in the management of ischemic stroke. However, the uncertain distribution and rapid clearance of extracellular vesicles impede their delivery efficiency. By utilizing membrane decoration or by encapsulating therapeutic cargo within extracellular vesicles, their delivery efficacy may be greatly improved. Furthermore, previous studies have indicated that microvesicles, a subset of large-sized extracellular vesicles, can transport mitochondria to neighboring cells, thereby aiding in the restoration of mitochondrial function post-ischemic stroke. Small extracellular vesicles have also demonstrated the capability to transfer mitochondrial components, such as proteins or deoxyribonucleic acid, or their sub-components, for extracellular vesicle-based ischemic stroke therapy. In this review, we undertake a comparative analysis of the isolation techniques employed for extracellular vesicles and present an overview of the current dominant extracellular vesicle modification methodologies. Given the complex facets of treating ischemic stroke, we also delineate various extracellular vesicle modification approaches which are suited to different facets of the treatment process. Moreover, given the burgeoning interest in mitochondrial delivery, we delved into the feasibility and existing research findings on the transportation of mitochondrial fractions or intact mitochondria through small extracellular vesicles and microvesicles to offer a fresh perspective on ischemic stroke therapy.","PeriodicalId":19113,"journal":{"name":"Neural Regeneration Research","volume":null,"pages":null},"PeriodicalIF":5.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141889787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Interconnections between diabetic corneal neuropathy and diabetic retinopathy: diagnostic and therapeutic implications. 糖尿病角膜神经病变与糖尿病视网膜病变之间的相互联系：诊断和治疗意义。

IF 5.9 2区医学

Neural Regeneration Research Pub Date : 2025-08-01 Epub Date: 2024-09-20 DOI: 10.4103/NRR.NRR-D-24-00509

Mingyi Yu, Faith Teo En Ning, Chang Liu, Yu-Chi Liu

{"title":"Interconnections between diabetic corneal neuropathy and diabetic retinopathy: diagnostic and therapeutic implications.","authors":"Mingyi Yu, Faith Teo En Ning, Chang Liu, Yu-Chi Liu","doi":"10.4103/NRR.NRR-D-24-00509","DOIUrl":"https://doi.org/10.4103/NRR.NRR-D-24-00509","url":null,"abstract":"Diabetic corneal neuropathy and diabetic retinopathy are ocular complications occurring in the context of diabetes mellitus. Diabetic corneal neuropathy refers to the progressive damage of corneal nerves. Diabetic retinopathy has traditionally been considered as damage to the retinal microvasculature. However, growing evidence suggests that diabetic retinopathy is a complex neurovascular disorder resulting from dysfunction of the neurovascular unit, which includes both the retinal vascular structures and neural tissues. Diabetic retinopathy is one of the leading causes of blindness and is frequently screened for as part of diabetic ocular screening. However, diabetic corneal neuropathy is commonly overlooked and underdiagnosed, leading to severe ocular surface impairment. Several studies have found that these two conditions tend to occur together, and they share similarities in their pathogenesis pathways, being triggered by a status of chronic hyperglycemia. This review aims to discuss the interconnection between diabetic corneal neuropathy and diabetic retinopathy, whether diabetic corneal neuropathy precedes diabetic retinopathy, as well as the relation between the stage of diabetic retinopathy and the severity of corneal neuropathy. We also endeavor to explore the relevance of a corneal screening in diabetic eyes and the possibility of using corneal nerve measurements to monitor the progression of diabetic retinopathy.","PeriodicalId":19113,"journal":{"name":"Neural Regeneration Research","volume":null,"pages":null},"PeriodicalIF":5.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142365899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Storage time affects the level and diagnostic efficacy of plasma biomarkers for neurodegenerative diseases. 储存时间会影响神经退行性疾病血浆生物标记物的水平和诊断效果。

IF 5.9 2区医学

Neural Regeneration Research Pub Date : 2025-08-01 Epub Date: 2024-04-16 DOI: 10.4103/NRR.NRR-D-23-01983

Lifang Zhao, Mingkai Zhang, Qimeng Li, Xuemin Wang, Jie Lu, Ying Han, Yanning Cai

{"title":"Storage time affects the level and diagnostic efficacy of plasma biomarkers for neurodegenerative diseases.","authors":"Lifang Zhao, Mingkai Zhang, Qimeng Li, Xuemin Wang, Jie Lu, Ying Han, Yanning Cai","doi":"10.4103/NRR.NRR-D-23-01983","DOIUrl":"https://doi.org/10.4103/NRR.NRR-D-23-01983","url":null,"abstract":"JOURNAL/nrgr/04.03/01300535-202508000-00027/figure1/v/2024-09-30T120553Z/r/image-tiff Several promising plasma biomarker proteins, such as amyloid-β (Aβ), tau, neurofilament light chain, and glial fibrillary acidic protein, are widely used for the diagnosis of neurodegenerative diseases. However, little is known about the long-term stability of these biomarker proteins in plasma samples stored at -80°C. We aimed to explore how storage time would affect the diagnostic accuracy of these biomarkers using a large cohort. Plasma samples from 229 cognitively unimpaired individuals, encompassing healthy controls and those experiencing subjective cognitive decline, as well as 99 patients with cognitive impairment, comprising those with mild cognitive impairment and dementia, were acquired from the Sino Longitudinal Study on Cognitive Decline project. These samples were stored at -80°C for up to 6 years before being used in this study. Our results showed that plasma levels of Aβ42, Aβ40, neurofilament light chain, and glial fibrillary acidic protein were not significantly correlated with sample storage time. However, the level of total tau showed a negative correlation with sample storage time. Notably, in individuals without cognitive impairment, plasma levels of total protein and tau phosphorylated protein threonine 181 (p-tau181)also showed a negative correlation with sample storage time. This was not observed in individuals with cognitive impairment. Consequently, we speculate that the diagnostic accuracy of plasma p-tau181 and the p-tau181 to total tau ratio may be influenced by sample storage time. Therefore, caution is advised when using these plasma biomarkers for the identification of neurodegenerative diseases, such as Alzheimer's disease. Furthermore, in cohort studies, it is important to consider the impact of storage time on the overall results.","PeriodicalId":19113,"journal":{"name":"Neural Regeneration Research","volume":null,"pages":null},"PeriodicalIF":5.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142365904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diabetic peripheral neuropathy and neuromodulation techniques: a systematic review of progress and prospects. 糖尿病周围神经病变与神经调控技术：进展与前景系统回顾。

IF 5.9 2区医学

Neural Regeneration Research Pub Date : 2025-08-01 Epub Date: 2024-09-06 DOI: 10.4103/NRR.NRR-D-24-00270

Rahul Mittal, Keelin McKenna, Grant Keith, Evan McKenna, Joana R N Lemos, Jeenu Mittal, Khemraj Hirani

{"title":"Diabetic peripheral neuropathy and neuromodulation techniques: a systematic review of progress and prospects.","authors":"Rahul Mittal, Keelin McKenna, Grant Keith, Evan McKenna, Joana R N Lemos, Jeenu Mittal, Khemraj Hirani","doi":"10.4103/NRR.NRR-D-24-00270","DOIUrl":"https://doi.org/10.4103/NRR.NRR-D-24-00270","url":null,"abstract":"Neuromodulation for diabetic peripheral neuropathy represents a significant area of interest in the management of chronic pain associated with this condition. Diabetic peripheral neuropathy, a common complication of diabetes, is characterized by nerve damage due to high blood sugar levels that lead to symptoms, such as pain, tingling, and numbness, primarily in the hands and feet. The aim of this systematic review was to evaluate the efficacy of neuromodulatory techniques as potential therapeutic interventions for patients with diabetic peripheral neuropathy, while also examining recent developments in this domain. The investigation encompassed an array of neuromodulation methods, including frequency rhythmic electrical modulated systems, dorsal root ganglion stimulation, and spinal cord stimulation. This systematic review suggests that neuromodulatory techniques may be useful in the treatment of diabetic peripheral neuropathy. Understanding the advantages of these treatments will enable physicians and other healthcare providers to offer additional options for patients with symptoms refractory to standard pharmacologic treatments. Through these efforts, we may improve quality of life and increase functional capacity in patients suffering from complications related to diabetic neuropathy.","PeriodicalId":19113,"journal":{"name":"Neural Regeneration Research","volume":null,"pages":null},"PeriodicalIF":5.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142365896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanisms behind elevated serum levels of plasminogen activator inhibitor-1 in frontotemporal lobar degeneration. 额颞叶变性患者血清中纤溶酶原激活物抑制剂-1水平升高的机制。

IF 5.9 2区医学

Neural Regeneration Research Pub Date : 2025-08-01 Epub Date: 2024-09-06 DOI: 10.4103/NRR.NRR-D-24-00335

Francesco Angelucci, Jakub Hort

引用次数: 0

Deciphering the mechanobiology of microglia in traumatic brain injury with advanced microsystems. 利用先进的微型系统解密创伤性脑损伤中的小胶质细胞机械生物学。

IF 5.9 2区医学

Neural Regeneration Research Pub Date : 2025-08-01 Epub Date: 2024-07-29 DOI: 10.4103/NRR.NRR-D-24-00371

Anthony Procès, Sylvain Gabriele

引用次数: 0

Neurocircuit regeneration by extracellular matrix reprogramming. 通过细胞外基质重编程实现神经回路再生

IF 5.9 2区医学

Neural Regeneration Research Pub Date : 2025-08-01 Epub Date: 2024-09-06 DOI: 10.4103/NRR.NRR-D-24-00506

Shengzhang Su, Ian N Levasseur, Kimberly M Alonge

引用次数: 0

Neuronal regulated cell death in aging-related neurodegenerative diseases: key pathways and therapeutic potentials. 与衰老相关的神经退行性疾病中的神经元调控细胞死亡：关键途径和治疗潜力。

IF 5.9 2区医学

Neural Regeneration Research Pub Date : 2025-08-01 Epub Date: 2024-07-29 DOI: 10.4103/NRR.NRR-D-24-00025

Run Song, Shiyi Yin, Jiannan Wu, Junqiang Yan

{"title":"Neuronal regulated cell death in aging-related neurodegenerative diseases: key pathways and therapeutic potentials.","authors":"Run Song, Shiyi Yin, Jiannan Wu, Junqiang Yan","doi":"10.4103/NRR.NRR-D-24-00025","DOIUrl":"10.4103/NRR.NRR-D-24-00025","url":null,"abstract":"Regulated cell death (such as apoptosis, necroptosis, pyroptosis, autophagy, cuproptosis, ferroptosis, disulfidptosis) involves complex signaling pathways and molecular effectors, and has been proven to be an important regulatory mechanism for regulating neuronal aging and death. However, excessive activation of regulated cell death may lead to the progression of aging-related diseases. This review summarizes recent advances in the understanding of seven forms of regulated cell death in age-related diseases. Notably, the newly identified ferroptosis and cuproptosis have been implicated in the risk of cognitive impairment and neurodegenerative diseases. These forms of cell death exacerbate disease progression by promoting inflammation, oxidative stress, and pathological protein aggregation. The review also provides an overview of key signaling pathways and crosstalk mechanisms among these regulated cell death forms, with a focus on ferroptosis, cuproptosis, and disulfidptosis. For instance, FDX1 directly induces cuproptosis by regulating copper ion valency and dihydrolipoamide S-acetyltransferase aggregation, while copper mediates glutathione peroxidase 4 degradation, enhancing ferroptosis sensitivity. Additionally, inhibiting the Xc- transport system to prevent ferroptosis can increase disulfide formation and shift the NADP + /NADPH ratio, transitioning ferroptosis to disulfidptosis. These insights help to uncover the potential connections among these novel regulated cell death forms and differentiate them from traditional regulated cell death mechanisms. In conclusion, identifying key targets and their crosstalk points among various regulated cell death pathways may aid in developing specific biomarkers to reverse the aging clock and treat age-related neurodegenerative conditions.","PeriodicalId":19113,"journal":{"name":"Neural Regeneration Research","volume":null,"pages":null},"PeriodicalIF":5.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141893911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

医学最新文献