Journal of Diabetes Investigation最新文献

Comment on "A machine learning approach to predicting severe diabetes distress in adults with type 1 diabetes mellitus". 对“预测成人1型糖尿病患者严重糖尿病痛苦的机器学习方法”的评论。

IF 3 3区医学

Journal of Diabetes Investigation Pub Date : 2026-05-09 DOI: 10.1111/jdi.70331

Yindan Song, Linwei Xia

引用次数: 0

Methodological considerations in interpreting circRNA profiles in diabetic retinopathy. 解释糖尿病视网膜病变中circRNA谱的方法学考虑。

IF 3 3区医学

Journal of Diabetes Investigation Pub Date : 2026-05-09 DOI: 10.1111/jdi.70334

Yindan Song, Xujun He

引用次数: 0

Searching for LADA in patients with Hashimoto's thyroiditis: A tool for the prevention of LADA. 寻找桥本甲状腺炎患者的LADA：一种预防LADA的工具。

IF 3 3区医学

Journal of Diabetes Investigation Pub Date : 2026-05-08 DOI: 10.1111/jdi.70318

Kozlowska Alicja Anna, Messina Maria Vittoria, Pozzilli Paolo

引用次数: 0

Effect of sodium-glucose cotransporter 2 inhibitors on heart failure readmission in older patients with diabetes: A Japanese claims-based cohort study. 钠-葡萄糖共转运蛋白2抑制剂对老年糖尿病患者心力衰竭再入院的影响：一项基于日本索赔的队列研究

IF 3 3区医学

Journal of Diabetes Investigation Pub Date : 2026-05-08 DOI: 10.1111/jdi.70335

Kazuya Hiura, Hirotaka Masuda, Masayuki Sakunami, Miki Yamashita

{"title":"Effect of sodium-glucose cotransporter 2 inhibitors on heart failure readmission in older patients with diabetes: A Japanese claims-based cohort study.","authors":"Kazuya Hiura, Hirotaka Masuda, Masayuki Sakunami, Miki Yamashita","doi":"10.1111/jdi.70335","DOIUrl":"https://doi.org/10.1111/jdi.70335","url":null,"abstract":"Aims: To evaluate the effect of sodium-glucose cotransporter 2 inhibitor (SGLT2i) administration at hospital discharge on heart failure (HF) readmission among older patients (≥75 years) with HF and diabetes and to compare the effectiveness of four SGLT2is, namely, ipragliflozin, empagliflozin, canagliflozin, and dapagliflozin, with a focus on direct head-to-head comparisons among individual SGLT2is.Materials and methods: We conducted a retrospective cohort study using the Medical Data Vision claims database. We included 66,895 patients aged ≥75 years who were emergently hospitalized for HF with comorbid diabetes between 2018 and 2022. Patients were categorized according to SGLT2i administration at discharge. Propensity score matching (PSM) was applied to adjust for baseline characteristics. The primary outcome was HF readmission, assessed using Kaplan-Meier analysis and Cox proportional hazards models. Inverse probability of treatment weighting (IPTW) was used to compare the four SGLT2is.Results: After PSM, SGLT2i users showed a significantly lower risk of HF readmission than nonusers (hazard ratio [HR] 0.91, 95% confidence interval [CI]: 0.85-0.97, P = 0.003). Sensitivity analysis censoring death and treatment discontinuation or initiation produced consistent results (HR 0.79, 95% CI: 0.74-0.85, P < 0.001). An IPTW-based comparison of the four agents revealed no significant differences, suggesting similar class-wide effectiveness.Conclusions: Among older patients with HF and diabetes, SGLT2i administration was associated with reduced HF readmission risk, with no meaningful differences among the four agents. These findings support a class-wide effect of SGLT2i and highlight the importance of their appropriate initiation and continuation in older adults.","PeriodicalId":190,"journal":{"name":"Journal of Diabetes Investigation","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147831038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Relative contributions of basal vs postprandial hyperglycaemia to overall glycaemic control in newly diagnosed Chinese adults with type 2 diabetes before and after 3 months' intensive glucose-lowering therapy. 新诊断的中国成人2型糖尿病患者在强化降糖治疗前后3个月的基础和餐后高血糖对总体血糖控制的相对贡献

IF 3 3区医学

Journal of Diabetes Investigation Pub Date : 2026-05-07 DOI: 10.1111/jdi.70327

Yixuan Sun, Yong Luo, Cong Xie, Karen L Jones, Michael Horowitz, Christopher K Rayner, Jianhua Ma, Tongzhi Wu

{"title":"Relative contributions of basal vs postprandial hyperglycaemia to overall glycaemic control in newly diagnosed Chinese adults with type 2 diabetes before and after 3 months' intensive glucose-lowering therapy.","authors":"Yixuan Sun, Yong Luo, Cong Xie, Karen L Jones, Michael Horowitz, Christopher K Rayner, Jianhua Ma, Tongzhi Wu","doi":"10.1111/jdi.70327","DOIUrl":"https://doi.org/10.1111/jdi.70327","url":null,"abstract":"Understanding the relative contributions of basal and postprandial hyperglycaemia (BH and PPH) to hyperglycaemia is pivotal to optimising the therapeutic strategies for type 2 diabetes (T2D). We used continuous glucose monitoring (CGM) to quantify longitudinal changes in the relative contributions of BH and PPH to overall hyperglycaemia in 22 treatment-naïve Han Chinese adults with T2D before and after 3 months of intensive glucose-lowering therapy. At baseline (HbA1c 10.0 ± 0.3%), BH predominated, contributing ~73-77% of overall hyperglycaemia. Following treatment (HbA1c 7.1 ± 0.2%), the contribution of BH decreased markedly (~35-38%), while PPH became the dominant contributor of hyperglycaemia (~62-66%). The improvement in glycaemic control was also accompanied by enhanced insulin secretion and sensitivity, without changes in gastric emptying. These findings provide longitudinal, CGM-based evidence of a dynamic shift in glycaemic determinants with therapy. Therapeutic strategies should be adapted accordingly, with initial focus on BH followed by increasing emphasis on PPH as glycaemic control improves.","PeriodicalId":190,"journal":{"name":"Journal of Diabetes Investigation","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147831230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Improved prognosis prediction of all-cause mortality and cardiovascular events by combined assessment of both ankle-brachial index and brachial-ankle pulse wave velocity in individuals with diabetes: The Kyushu prevention study for atherosclerosis, a prospective, multicenter survey. 通过联合评估腕部-肱指数和腕部-踝脉波速度改善糖尿病患者全因死亡率和心血管事件的预后预测：九州动脉粥样硬化预防研究，一项前瞻性，多中心调查。

IF 3 3区医学

Journal of Diabetes Investigation Pub Date : 2026-05-07 DOI: 10.1111/jdi.70324

Erina Eto, Yasutaka Maeda, Noriyuki Sonoda, Hajime Nawata, Ryoichi Takayanagi, Michio Shimabukuro, Toyoshi Inoguchi

{"title":"Improved prognosis prediction of all-cause mortality and cardiovascular events by combined assessment of both ankle-brachial index and brachial-ankle pulse wave velocity in individuals with diabetes: The Kyushu prevention study for atherosclerosis, a prospective, multicenter survey.","authors":"Erina Eto, Yasutaka Maeda, Noriyuki Sonoda, Hajime Nawata, Ryoichi Takayanagi, Michio Shimabukuro, Toyoshi Inoguchi","doi":"10.1111/jdi.70324","DOIUrl":"https://doi.org/10.1111/jdi.70324","url":null,"abstract":"Aims/introduction: People with diabetes exhibit early-stage cardiovascular disease (CVD). In this study, we developed a new diagnostic algorithm to predict all-cause mortality and CVD using both the ankle-brachial index (ABI) and brachial-ankle pulse wave velocity (baPWV) in individuals with diabetes.Materials and methods: This study utilized data from the Kyushu Prevention Study for Atherosclerosis, a prospective, multicenter survey. A total of 3,933 participants with diabetes were followed. The primary outcomes were all-cause mortality and CVD. Risk was categorized based on ABI and baPWV, and the prognostic differences were evaluated. Additionally, the independence of this classification from the Framingham Risk Score (FRS) was tested.Results: ABI was the strongest predictor of all-cause mortality. Individuals with a low ABI (<0.70) had the highest risk, while those with an intermediate ABI (0.70-1.0) exhibited a risk similar to individuals with the extremely high baPWV (≥24 m/s), forming the second highest-risk group. For coronary heart disease, ABI and baPWV had complementary predictive value. Individuals with a low ABI (<1.0) or high baPWV (≥19 m/s) were at the highest risk, whereas those with a low baPWV (<14 m/s) had the lowest risk. For cerebrovascular disease, only baPWV was a significant predictor, with risk cutoffs above 23 m/s and below 14 m/s.Conclusions: We developed a new diagnostic algorithm incorporating both ABI and baPWV to predict all-cause mortality and CVD in individuals with diabetes. This algorithm improved the accuracy of mortality and CVD risk assessment and was independent from the FRS.","PeriodicalId":190,"journal":{"name":"Journal of Diabetes Investigation","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147831171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Paroxysmal sympathetic hyperactivity secondary to hypoglycemic encephalopathy: A case report. 低血糖性脑病继发阵发性交感神经亢进1例报告。

IF 3 3区医学

Journal of Diabetes Investigation Pub Date : 2026-05-07 DOI: 10.1111/jdi.70332

Yushi Kohzuki, Junpei Yamamoto, Yuki Kaminaga, Yoko Kayaba, Hiroshi Onodera, Masahiro Usui

引用次数: 0

Sodium-glucose cotransporter 2 inhibition and injection burden in mild diabetic macular edema: An exploratory post hoc analysis of the COMET trial. 轻度糖尿病性黄斑水肿的钠-葡萄糖共转运蛋白2抑制和注射负担：COMET试验的探索性事后分析

IF 3 3区医学

Journal of Diabetes Investigation Pub Date : 2026-05-06 DOI: 10.1111/jdi.70330

Yoko Takatsuna, Ryoichi Ishibashi, Masaya Koshizaka, Tomoaki Tatsumi, Takayuki Baba, Shuichi Yamamoto, Koutaro Yokote

{"title":"Sodium-glucose cotransporter 2 inhibition and injection burden in mild diabetic macular edema: An exploratory post hoc analysis of the COMET trial.","authors":"Yoko Takatsuna, Ryoichi Ishibashi, Masaya Koshizaka, Tomoaki Tatsumi, Takayuki Baba, Shuichi Yamamoto, Koutaro Yokote","doi":"10.1111/jdi.70330","DOIUrl":"https://doi.org/10.1111/jdi.70330","url":null,"abstract":"Aims: To investigate the potential of sodium-glucose cotransporter 2 inhibitors (SGLT2i) as a less invasive treatment option for mild diabetic macular edema (DMO) via post hoc subgroup analysis. Previous findings were derived exclusively from observational studies, and no interventional trials based on protocol-defined criteria had been conducted.Materials and methods: Based on the COMET trial data, this post hoc analysis targeted mild DME cases, defined by baseline central retinal thickness (CRT) ≤375 μm and best-corrected visual acuity (BCVA) ≤0.155 (logMAR). Patients were randomized to SGLT2i (luseogliflozin) or sulfonylurea (SU, glimepiride) groups. Mild subgroups were compared with the corresponding non-mild cases. The primary outcome was the 48-week frequency of intravitreal ranibizumab injections (IVRs).Results: In the CRT ≤375 μm subgroup, IVR frequency was significantly lower with SGLT2i vs SU (mean 0.5 ± 1.0 vs 4.3 ± 0.8; P = 0.005, adjusted ancova. Cohen's d of 2.1). The cumulative mean number of IVRs was significantly lower in the SGLT2i group than in the SU group (P = 0.004, hazard ratio 0.29, 95% confidence interval 0.12-0.67). In the BCVA ≤ 0.155 subgroup, whose mean CRT exceeded 400 μm, no significant difference in IVR frequency was observed between the SGLT2i-treated and SU-treated patients. In addition, no intergroup differences were found in patients outside the mild subgroups.Conclusions: In this exploratory analysis, SGLT2 inhibition was associated with fewer intravitreal injections in patients meeting the CRT-based mild criteria. These findings are hypothesis-generating and warrant confirmation in future prospective studies.","PeriodicalId":190,"journal":{"name":"Journal of Diabetes Investigation","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147831296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prediction of incident heart failure in type 2 diabetes mellitus: Rationale and design of the DM-HEART study. 2型糖尿病心力衰竭的预测：DM-HEART研究的原理和设计

IF 3 3区医学

Journal of Diabetes Investigation Pub Date : 2026-05-06 DOI: 10.1111/jdi.70255

Jiun-Lu Lin, Yen-Wen Wu, Sung-Chen Liu, Chung-Ming Tu, Heng-Hsu Lin, Yi-Fu Lin, Hao-Yun Chang, Ming-Nan Chien, Chih-Yuan Wang, Chung-Lieh Hung

{"title":"Prediction of incident heart failure in type 2 diabetes mellitus: Rationale and design of the DM-HEART study.","authors":"Jiun-Lu Lin, Yen-Wen Wu, Sung-Chen Liu, Chung-Ming Tu, Heng-Hsu Lin, Yi-Fu Lin, Hao-Yun Chang, Ming-Nan Chien, Chih-Yuan Wang, Chung-Lieh Hung","doi":"10.1111/jdi.70255","DOIUrl":"https://doi.org/10.1111/jdi.70255","url":null,"abstract":"Preclinical heart failure (HF) (stages A and B) is common but easily overlooked in asymptomatic patients with type 2 diabetes (T2D). There is a paucity of evidence regarding how coexisting risk factors contribute to the development of HF in asymptomatic Asian patients with T2D, and there is a lack of guidance on the early identification of asymptomatic patients to help cost-effectively allocate preventive therapies. The Diabetes Mellitus Heart Failure Events Analysis and Risk Tracking (DM-HEART) trial, a prospective, multicenter, longitudinal cohort study, recruited asymptomatic patients with T2D and no prior HF between January 2021 and June 2024, with a minimum follow-up period of 12 months. The primary outcome was incident HF, defined as new-onset HF (requiring either hospitalization or an urgent care visit). Secondary outcomes are measured as 3-point major adverse cardiovascular events, comprised of cardiovascular death, non-fatal myocardial infarction, or non-fatal stroke. DM-HEART will provide epidemiological data on the incidence of HF and assess the prognostic utility of clinical parameters, including N-terminal pro-B-type natriuretic peptide (NT-proBNP), for predicting incident HF events among asymptomatic patients with T2D in preclinical stages of HF. Furthermore, we aim to determine the optimal NT-proBNP cut-off value for predicting incident HF events in East Asian patients with diabetes.","PeriodicalId":190,"journal":{"name":"Journal of Diabetes Investigation","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147831190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Type 1 diabetes-specific distress among adults with type 1 diabetes in Japan. 日本成人1型糖尿病患者的1型糖尿病特异性痛苦

IF 3 3区医学

Journal of Diabetes Investigation Pub Date : 2026-05-02 DOI: 10.1111/jdi.70328

Naoki Sakane, Masayuki Domich, Akiko Suganum, Seiko Sakane

{"title":"Type 1 diabetes-specific distress among adults with type 1 diabetes in Japan.","authors":"Naoki Sakane, Masayuki Domich, Akiko Suganum, Seiko Sakane","doi":"10.1111/jdi.70328","DOIUrl":"https://doi.org/10.1111/jdi.70328","url":null,"abstract":"Background: The prevalence and characteristics of diabetes distress (DD) in Japanese adults with type 1 diabetes mellitus (T1D) remain unclear. Therefore, this study aimed to investigate the prevalence and associated features of DD in this population. A cross-sectional study was conducted using the Type 1 Diabetes Distress Scale (T1-DDS), the Problem Areas in Diabetes (PAID) scale, and the Hypoglycemia Fear Survey (HFS). Data from 117 adults with T1D were analyzed. Group comparisons were made using t-tests and anova, and associations were assessed using Spearman's rank correlation. Confirmatory factor analysis (CFA) was used to examine the structure of the T1-DDS.Results: Of the 144 screened participants, 117 (mean age: 50.6 ± 12.8 years; 44.4% male; mean diabetes duration: 18.1 ± 10.7 years; mean HbA1c: 7.6% ± 0.9%) were included in the analysis. Moderate and high DD were observed in 30.8% and 16.2%, respectively. Participants with high DD had significantly higher PAID and HFS-Worry/Behavior scores, despite no significant differences in age, sex, diabetes duration, or HbA1c. Among T1-DDS subscales, Powerlessness and Eating Distress had the highest mean scores. All subscale scores were correlated with total distress (rho = 0.636-0.916) and showed good internal consistency (Cronbach's alpha = 0.784-0.875). CFA supported the seven-factor structure with marginal-to-acceptable model fit.Conclusion: DD is prevalent in Japanese adults with T1D. The T1-DDS can be a useful screening tool for identifying individuals experiencing diabetes-related emotional burden and guiding personalized interventions for these individuals.","PeriodicalId":190,"journal":{"name":"Journal of Diabetes Investigation","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147808634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0