Journal of Diabetes Investigation最新文献

Association of brachial-ankle pulse wave velocity with subclinical diabetic peripheral neuropathy in patients with type 2 diabetes mellitus.

IF 3.2 3区医学

Journal of Diabetes Investigation Pub Date : 2025-02-28 DOI: 10.1111/jdi.70008

Yue Wang, Ping Liu, Chang Shang, Yahui Wang, Mengfei Yuan, Guozhen Zhao, Luying Sun

{"title":"Association of brachial-ankle pulse wave velocity with subclinical diabetic peripheral neuropathy in patients with type 2 diabetes mellitus.","authors":"Yue Wang, Ping Liu, Chang Shang, Yahui Wang, Mengfei Yuan, Guozhen Zhao, Luying Sun","doi":"10.1111/jdi.70008","DOIUrl":"https://doi.org/10.1111/jdi.70008","url":null,"abstract":"Aim: Subclinical diabetic peripheral neuropathy (sDPN) in patients with type 2 diabetes mellitus is insidious, but has been complicated with neurological damage. The aim of this study was to investigate the association between brachial-ankle pulse wave velocity (baPWV) and sDPN in patients with type 2 diabetes mellitus, and to provide reference for clinical prevention and treatment of sDPN.Materials and methods: From November 2021 to May 2024, a total of 711 type 2 diabetes mellitus patients without symptoms and signs of peripheral nerve damage were recruited. According to whether the nerve conduction velocity (NCV) was abnormal or not, they were divided into the sDPN group and the non-diabetic peripheral neuropathy (non-DPN) group. Logistic regression model, restricted cubic spline (RCS) analysis and subgroup analysis were used to evaluate the correlation between baPWV and sDPN.Results: A total of 204 (28.69%) of the 711 participants were diagnosed with sDPN. Both amplitude and conduction velocity were negatively correlated with baPWV. In the fully adjusted model, elevated baPWV levels were significantly associated with an increased sDPN risk, with odds ratio (OR) = 1.084, 95% confidence interval (CI): (1.023, 1.148), P = 0.006. RCS showed a linear association between baPWV and sDPN. Subgroup analysis further confirmed that the positive association between baPWV and sDPN was consistent and robust across groups.Conclusions: Our study indicates a pronounced link between higher baPWV and increased risk of sDPN among type 2 diabetes mellitus patients without symptoms and signs of peripheral nerve damage. These findings underscore the importance of baPWV for early identification of sDPN.","PeriodicalId":190,"journal":{"name":"Journal of Diabetes Investigation","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143522315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of administration and withdrawal of the sodium-glucose cotransporter 2 inhibitor, tofogliflozin, on renal protection in individuals with type 2 diabetes mellitus and diabetic nephropathy: A multicenter, single-arm study (RESTORE-nephropathy study).

IF 3.2 3区医学

Journal of Diabetes Investigation Pub Date : 2025-02-27 DOI: 10.1111/jdi.70018

Ayako Shigeta, Masami Tanaka, Shu Meguro, Jiro Morimoto, Takatoshi Imai, Akira Yamauchi, Yasuhiko Kanazawa, Toshihide Kawai, Koichiro Azuma, Satoru Yamada, Sho Endo, Hiroshi Itoh, Kaori Hayashi

{"title":"Effect of administration and withdrawal of the sodium-glucose cotransporter 2 inhibitor, tofogliflozin, on renal protection in individuals with type 2 diabetes mellitus and diabetic nephropathy: A multicenter, single-arm study (RESTORE-nephropathy study).","authors":"Ayako Shigeta, Masami Tanaka, Shu Meguro, Jiro Morimoto, Takatoshi Imai, Akira Yamauchi, Yasuhiko Kanazawa, Toshihide Kawai, Koichiro Azuma, Satoru Yamada, Sho Endo, Hiroshi Itoh, Kaori Hayashi","doi":"10.1111/jdi.70018","DOIUrl":"https://doi.org/10.1111/jdi.70018","url":null,"abstract":"Aims/introduction: The mechanisms of the renoprotective effects of sodium-glucose cotransporter 2 inhibitors are unknown. This study aimed to explore the effect and mechanism of tofogliflozin on urinary albumin by administration, withdrawal, and re-administration.Materials and methods: Individuals with type 2 diabetes mellitus and stage 2 or 3 diabetic nephropathy were enrolled. Tofogliflozin was administered for 24 weeks, withdrawn for 12 weeks (withdrawal period), and re-administered for 24 weeks. The primary endpoint was the change in urinary albumin/creatinine ratio (UACR). The secondary endpoints included hemoglobin A1c (HbA1c), hepatic biomarkers, lipid profiles, physical examinations, and blood counts.Results: A total of 47 individuals were enrolled. UACR significantly decreased throughout the observation period. It also significantly decreased, increased, and again decreased during the period of the 1st administration, withdrawal, and re-administration, respectively. HbA1c, body weight, waist circumference, and systolic blood pressure also showed the same tendency. Aspartate aminotransferase and alanine aminotransferase significantly decreased throughout the observation period, but did not increase during the withdrawal period.Conclusions: Urinary albumin improved during the administration of tofogliflozin and worsened during its withdrawal, suggesting the reversibility of its renoprotective effect. The administration of tofogliflozin should be continued to avoid the reversal of glycemic control, renoprotective effects, and other beneficial effects.","PeriodicalId":190,"journal":{"name":"Journal of Diabetes Investigation","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143514296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Executive function deficits in adults with childhood-onset type 1 diabetes mellitus: Evidence from Wisconsin card sorting test performance. 儿童期发病的 1 型糖尿病成人的执行功能缺陷：威斯康星卡片分类测试成绩的证据。

IF 3.2 3区医学

Journal of Diabetes Investigation Pub Date : 2025-02-26 DOI: 10.1111/jdi.70007

Jing He, Wenjing Zou, Hongyu Du, Songzhuzi Liu, Xia Li, Zhiguang Zhou, Xiongzhao Zhu

{"title":"Executive function deficits in adults with childhood-onset type 1 diabetes mellitus: Evidence from Wisconsin card sorting test performance.","authors":"Jing He, Wenjing Zou, Hongyu Du, Songzhuzi Liu, Xia Li, Zhiguang Zhou, Xiongzhao Zhu","doi":"10.1111/jdi.70007","DOIUrl":"https://doi.org/10.1111/jdi.70007","url":null,"abstract":"Background: Executive functions (EFs) are important for the Type 1 diabetes mellitus (T1DM) self-care perspective. This study aimed to investigate whether patients with T1DM have poorer EFs than healthy controls (HCs) and whether there are differences in EFs between childhood-onset and adult-onset T1DM.Methods: This study included 94, 110, and 100 participants with childhood-onset and adult-onset T1DM and HCs, respectively. All participants completed the Wisconsin Card Sorting Test to assess EFs. The Chinese version of the WAIS and BDI-II were performed to determine IQ and emotion in all participants.Results: The childhood-onset group made lower scores of WCST total errors (P = 0.015), perseverative errors (P = 0.038) than the HC group, and the adult-onset group made lower scores of WCST total errors (P = 0.025) than the HC group. In the diabetes group, after controlling diabetes duration, the childhood-onset group made significantly higher scores of WCST total errors (P = 0.040), perseverative errors (P = 0.038), and non-perseverative errors (P = 0.013). In the childhood-onset group, perseverative errors were significantly associated with duration of T1DM (β = -0.24, t = -2.34, P = 0.021), and the history of severe hypoglycemia affects the non-perseverative errors(β = -0.26, t = -2.55, P = 0.013).Conclusions: T1DM is associated with EF decrements, and there are differences in EFs between childhood-onset and adult-onset T1DM. These findings indicate that we should consider detecting and intervening in EF deficits in the T1DM population according to the age of onset.","PeriodicalId":190,"journal":{"name":"Journal of Diabetes Investigation","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143497638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

YY2 mediates transcriptional repression of PHGDH and expedites oxidative stress in retinal pigment epithelial cells in diabetic retinopathy.

IF 3.2 3区医学

Journal of Diabetes Investigation Pub Date : 2025-02-24 DOI: 10.1111/jdi.70011

Xiang Lei, Xiu Wang, Xinai Zhang

{"title":"YY2 mediates transcriptional repression of PHGDH and expedites oxidative stress in retinal pigment epithelial cells in diabetic retinopathy.","authors":"Xiang Lei, Xiu Wang, Xinai Zhang","doi":"10.1111/jdi.70011","DOIUrl":"https://doi.org/10.1111/jdi.70011","url":null,"abstract":"Aims/introduction: Phosphoglycerate dehydrogenase (PHGDH), which controls serine synthesis, has been linked to retinal disease. However, there are no clues about its involvement in the diabetic retinopathy (DR) progression. Therefore, we aimed to investigate the relationship between PHGDH, serine synthesis, and DR and their underlying molecular mechanisms.Method: Differentially expressed genes in DR were screened using bioinformatics tools. DR mice were induced, and retinal histopathology was observed in mice. Overexpression of PHGDH was induced in the DR mice to measure l-serine, ROS, and MDA content in the retinas of DR mice. ARPE-19 cells were transfected with overexpression of PHGDH and exposed to high glucose to induce a DR in vitro model, and cell viability and apoptosis assays, serine content, and oxidative stress factor measurement were conducted. The transcriptional regulation of PHGDH by YY2 was explored by ChIP and dual-luciferase reporter assays. Finally, the combined role of YY2 and PHGDH in regulating serine synthesis, oxidative stress, and ferroptosis was investigated.Results: PHGDH expression was reduced in DR mice, and overexpression of PHGDH alleviated DR progression by promoting serine synthesis and attenuating oxidative stress. YY2 bound to the promoter of PHGDH and mediated its transcriptional repression. YY2-mediated transcriptional repression of PHGDH caused disturbances in serine synthesis, leading to oxidative stress-triggered ferroptosis.Conclusions: Our data prove that YY2 plays a vital role in modulating PHGDH expression, impairing serine synthesis, and expediting oxidative stress and ferroptosis.","PeriodicalId":190,"journal":{"name":"Journal of Diabetes Investigation","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143482040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

MetS-Z: A gender- and age-specific scoring system for predicting type 2 diabetes.

IF 3.2 3区医学

Journal of Diabetes Investigation Pub Date : 2025-02-13 DOI: 10.1111/jdi.70004

Paul Wei-Che Hsu, Yi-Rong Chen, Wayne Huey-Herng Sheu

{"title":"MetS-Z: A gender- and age-specific scoring system for predicting type 2 diabetes.","authors":"Paul Wei-Che Hsu, Yi-Rong Chen, Wayne Huey-Herng Sheu","doi":"10.1111/jdi.70004","DOIUrl":"https://doi.org/10.1111/jdi.70004","url":null,"abstract":"Aims: Current metabolic syndrome (mets) criteria often lack consideration for age and gender differences. This study introduces the mets-Z score, a novel tool designed to enhance mets assessment and improve long-term outcome predictions.Materials and methods: The mets-Z score was developed using principal component analysis (PCA) to weight five mets indicators-waist circumference, blood glucose, blood pressure, high-density lipoprotein (HDL) cholesterol, and triglycerides-by gender and age. Data from 188,739 Taiwan Biobank participants, stratified by gender and age groups (20-39, 40-54, 55-64, 65+ years), were analyzed. Predictive performance for type 2 diabetes mellitus onset was assessed over a 4- to 5-year follow-up.Results: The mets-Z score achieved superior accuracy in predicting type 2 diabetes mellitus onset, with an AUC of 0.76 in men and 0.80 in women, significantly outperforming conventional indices (P < 0.0001).Conclusions: By integrating age- and gender-specific variations, the mets-Z score provides a more personalized and precise tool for assessing metabolic and diabetes risk, surpassing existing methods. The tool is available for public use at http://bioinfolab.nhri.edu.tw/metsz/, supporting broader applications in precision medicine.","PeriodicalId":190,"journal":{"name":"Journal of Diabetes Investigation","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143404908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Commentary on "Diminished levels of insulin-like growth factor-1 may be a risk factor for peripheral neuropathy in type 2 diabetes patients".

IF 3.2 3区医学

Journal of Diabetes Investigation Pub Date : 2025-02-12 DOI: 10.1111/jdi.70009

Mostafa Javanian, Mohammad Barary, Fatemeh Rasulpur, Ali Alizadeh Khatir, Soheil Ebrahimpour

引用次数: 0

Pharmacokinetic properties of once-weekly insulin icodec in Chinese individuals with type 2 diabetes.

IF 3.2 3区医学

Journal of Diabetes Investigation Pub Date : 2025-02-12 DOI: 10.1111/jdi.70005

Yijun Li, Ariel Fu, Shan Jiang, Ann-Katrine Kjærsgaard Jøns, Beibei Liang, Qi Ni, Rasmus Ribel-Madsen, Lisbet Westergaard

{"title":"Pharmacokinetic properties of once-weekly insulin icodec in Chinese individuals with type 2 diabetes.","authors":"Yijun Li, Ariel Fu, Shan Jiang, Ann-Katrine Kjærsgaard Jøns, Beibei Liang, Qi Ni, Rasmus Ribel-Madsen, Lisbet Westergaard","doi":"10.1111/jdi.70005","DOIUrl":"https://doi.org/10.1111/jdi.70005","url":null,"abstract":"Introduction: Insulin icodec is a novel once-weekly basal insulin developed for the treatment of diabetes. The aim of this study was to investigate the pharmacokinetics of icodec in Chinese individuals with type 2 diabetes.Materials and methods: In an open-label, single-group study, 24 Chinese individuals with type 2 diabetes (18-64 years, glycated hemoglobin ≤9.0%, body mass index 18.0-38.0 kg/m2) were treated with once-weekly icodec for 6 weeks. The icodec dose was constant and individualized, aimed at achieving self-measured plasma glucose of 4.4-7.0 mmol/L before breakfast. Blood samples were drawn from the first icodec dose until 35 days after last dose and were analyzed for total serum icodec concentration (i.e., the sum of albumin-bound and unbound icodec).Results: Icodec trough concentrations measured following initiation of once-weekly icodec dosing suggested that clinical steady state for icodec was achieved after approximately 3-4 weeks of dosing. When at steady state, icodec exposure covered the full 1-week dosing interval. The geometric mean half-life was 159 h. The slopes of total icodec exposure (AUCτ,SS) and maximum icodec concentration (Cmax,SS) vs icodec dose did not differ significantly from 1, supporting dose-proportionality for both AUCτ,SS (P = 0.40) and Cmax,SS (P = 0.43). Icodec was safe and well tolerated, and no new safety issues were identified in relation to icodec in this study.Discussion: The pharmacokinetic properties of icodec assessed at steady state in this study demonstrated well-distributed exposure across the 1-week dosing interval and a half-life that supports once-weekly administration in Chinese individuals with type 2 diabetes.","PeriodicalId":190,"journal":{"name":"Journal of Diabetes Investigation","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143397559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy and safety of premixed versus basal-bolus regimens as intensification of insulin therapy in patients with type 2 diabetes mellitus: A systematic review and meta-analysis of randomized clinical trials.

IF 3.2 3区医学

Journal of Diabetes Investigation Pub Date : 2025-02-05 DOI: 10.1111/jdi.70002

Mohsen Dehghani, Masoumeh Sadeghi, Farzaneh Barzkar, Mohammad Ebrahim Khamseh, Ashkan Torshizian, Hamid Reza Baradaran

{"title":"Efficacy and safety of premixed versus basal-bolus regimens as intensification of insulin therapy in patients with type 2 diabetes mellitus: A systematic review and meta-analysis of randomized clinical trials.","authors":"Mohsen Dehghani, Masoumeh Sadeghi, Farzaneh Barzkar, Mohammad Ebrahim Khamseh, Ashkan Torshizian, Hamid Reza Baradaran","doi":"10.1111/jdi.70002","DOIUrl":"https://doi.org/10.1111/jdi.70002","url":null,"abstract":"Aim: To estimate the efficacy and safety of the basal-bolus and premixed insulin as intensification regimens in patients with type 2 diabetes mellitus (T2DM).Methods: A comprehensive search of online databases was performed until December 2022 to identify randomized controlled trials (RCTs) comparing premixed insulin versus basal-bolus regimen with treat-to-target intention. The Cochrane ROB-2 tool and GRADE approach were used for quality assessment and certainty of the evidence, respectively. Pooled weighted mean difference (WMD) and odds ratio (OR) were calculated using random-effects meta-analysis models.Results: Eighteen RCTs were included in the meta-analysis, and 66% had a low risk of bias. We found no significant difference between the two regimens regarding HbA1c reduction (WMD: 0.03% [-0.05%, 0.10%]). The basal-bolus regimen improved fasting plasma glucose (FPG) more than the premixed regimen (WMD: 6.35 mg/dL [0.31, 12.39]). Both had similar effects on weight gain. The odds of developing overall, nocturnal, and severe hypoglycemia were comparable (pooled OR: 0.9, 1.02, and 1.00, respectively) with no heterogeneity. Findings of the model were robust. The certainty of the evidence was moderate to high for all outcomes except FPG.Conclusions: Two regimens are clinically comparable. Patient preference should be considered when adopting an individualized approach in a real-world setting.","PeriodicalId":190,"journal":{"name":"Journal of Diabetes Investigation","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143187872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Validation using item response theory, and assessment of sensitivity to change of the Hypoglycemia Awareness Questionnaire in patients with type 2 diabetes treated with insulin.

IF 3.2 3区医学

Journal of Diabetes Investigation Pub Date : 2025-02-04 DOI: 10.1111/jdi.14406

Julieth Patricia García-Lugo, Ana Julia Carrillo Algarra, Fabio Alexander Sierra-Matamoros, Sandra Milena Hernández-Zambrano, Diana Cristina Henao-Carrillo

{"title":"Validation using item response theory, and assessment of sensitivity to change of the Hypoglycemia Awareness Questionnaire in patients with type 2 diabetes treated with insulin.","authors":"Julieth Patricia García-Lugo, Ana Julia Carrillo Algarra, Fabio Alexander Sierra-Matamoros, Sandra Milena Hernández-Zambrano, Diana Cristina Henao-Carrillo","doi":"10.1111/jdi.14406","DOIUrl":"https://doi.org/10.1111/jdi.14406","url":null,"abstract":"Aims/introduction: It is important to develop valid tools to evaluate hypoglycemia perception such as the Hypoglycemia Awareness Questionnaire (HypoA-Q) in patients with Type 2 Diabetes (T2D). The aim of the study is to validate the HypoA-Q in patients with T2D treated with insulin using item response theory.Materials and methods: Individuals with T2D treated with insulin were included by non-random convenience sampling. A partial credit model was used for validation using item response theory, infit, and outfit statistics were calculated, person-item map and item characteristic curves were plotted, and differential item functioning was assessed.Results: The study included 502 participants, the mean age at diagnosis of diabetes was 47.8 ± 13.9 years, the median time with the diagnosis was 15 years (IQR: 9-22), and the mean HbA1c 71 ± 27.3 mmol/mL (8.6 ± 2.5%), 48.6% had Glomerular Filtration Rate >60 mL/min/min2. Item fit was found with items covering the full range of the construct of the participant population, although response options could be simplified. The person-item map showed that the scale covers a wide range of the construct and that the scale has items to measure these different levels. Item bias was not evident when comparing subgroups by age, sex and treatment.Conclusions: The HypoA-Q is a valid measure for assessing hypoglycemia awareness in insulin-treated T2D patients because it has items that fit the measurement process, measures a wide range of awareness, and is free of biases related to gender, age, treatment, and duration of diabetes.","PeriodicalId":190,"journal":{"name":"Journal of Diabetes Investigation","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143187873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Population profile and glycemic control following initiation or switch of injectable therapies in Tianjin, China: A real-world retrospective cohort study of adults with type 2 diabetes.

IF 3.2 3区医学

Journal of Diabetes Investigation Pub Date : 2025-02-03 DOI: 10.1111/jdi.14415

Qiumei Zhang, Yaqing Fan, Xixi Liu, Minlu Zhang, Jiewen Zhang, Qin Du, Lei Kang, Liming Chen

{"title":"Population profile and glycemic control following initiation or switch of injectable therapies in Tianjin, China: A real-world retrospective cohort study of adults with type 2 diabetes.","authors":"Qiumei Zhang, Yaqing Fan, Xixi Liu, Minlu Zhang, Jiewen Zhang, Qin Du, Lei Kang, Liming Chen","doi":"10.1111/jdi.14415","DOIUrl":"https://doi.org/10.1111/jdi.14415","url":null,"abstract":"Aims: To evaluate characteristics and glycemic outcomes in individuals with type 2 diabetes using injectable therapies in real-world clinical practice in Tianjin, China.Materials and methods: Data from inpatients and outpatients receiving injectable therapies between January 2015 and December 2019 were collected from the Tianjin regional electronic medical records and retrospectively analyzed. Seven cohorts were identified, including individuals initiating injectable therapies (premixed insulin [n = 4,687], basal insulin [4,177], or glucagon-like peptide-1 receptor agonists [541]) or switching injectable therapies (premixed insulin to basal insulin [1,298], basal insulin to premixed insulin [1,457], basal insulin to basal + bolus insulin [1,772], or glucagon-like peptide-1 receptor agonists to basal insulin ± glucagon-like peptide-1 receptor agonists [82]).Results: In participants initiating therapy, glycated hemoglobin and fasting plasma glucose were highest in the basal insulin cohort, while among participants switching therapy, the highest values were in the basal insulin ± glucagon-like peptide-1 receptor agonists cohort. Initiating therapy with premixed or basal insulin and switching from basal insulin to basal + bolus insulin improved glycemic control over 12 months. A mean delay in initiating therapy of up to 13 months after oral glucose-lowering drug failure was observed, with 60% having a delay of >6 months. This delay was associated with a lower proportion achieving glycemic control 3 months after initiation.Conclusions: Effectiveness was not observed at all time points in all cohorts, suggesting some treatments were not used in the appropriate population. Delays in initiating injectable therapies were observed and were associated with poor glycemic control.","PeriodicalId":190,"journal":{"name":"Journal of Diabetes Investigation","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143121871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0