Journal of Diabetes Investigation最新文献

{"title":"Relation between obesity and health disorders as revealed by the J-ORBIT clinical information collection system directly linked to electronic medical records (J-ORBIT 1).","authors":"Seiji Nishikage, Yushi Hirota, Yasushi Nakagawa, Masamichi Ishii, Mitsuru Ohsugi, Eiichi Maeda, Kai Yoshimura, Akane Yamamoto, Tomofumi Takayoshi, Takehiro Kato, Daisuke Yabe, Munehide Matsuhisa, Jun Eguchi, Jun Wada, Yukihiro Fujita, Shinji Kume, Hiroshi Maegawa, Kana Miyake, Nobuhiro Shojima, Toshimasa Yamauchi, Koutaro Yokote, Kohjiro Ueki, Kengo Miyo, Wataru Ogawa","doi":"10.1111/jdi.70021","DOIUrl":"https://doi.org/10.1111/jdi.70021","url":null,"abstract":"<p><strong>Aims/introduction: </strong>Obesity triggers various health disorders, but information on these disorders in real-world settings remains limited. To address this knowledge gap, we developed a database directly linked to electronic medical records (EMRs). We here present the baseline data for this database, designated Japan Obesity Research Based on electronIc healTh Records (J-ORBIT).</p><p><strong>Materials and methods: </strong>Individuals with obesity disease diagnosed according to the criteria of the Japan Society for the Study of Obesity were registered in J-ORBIT from seven medical centers in Japan. We analyzed the relationship between body mass index (BMI), clinical characteristics, and the prevalence of obesity-related health disorders in this cohort.</p><p><strong>Results: </strong>Data were obtained from 1,169 individuals, with a mean (±SD) age of 56.9 ± 15.3 years and a BMI of 31.4 ± 6.1 kg/m². The prevalence of health disorders varied substantially across BMI categories, with a higher BMI being associated with an increased prevalence of hyperuricemia or gout, obstructive sleep apnea syndrome or obesity hypoventilation syndrome, musculoskeletal disorders, and obesity-related kidney disease, as well as with a higher frequency of both a family history of obesity and of a history of childhood obesity. Among individuals with a BMI of ≥25 kg/m², the prevalence of hypertension and dyslipidemia did not increase with BMI, whereas that of glucose intolerance decreased with increasing BMI.</p><p><strong>Conclusions: </strong>The J-ORBIT system, which collects clinical data in real time directly from EMRs, has the potential to provide insight into obesity and its associated health conditions, thereby contributing to improved care of affected individuals.</p>","PeriodicalId":190,"journal":{"name":"Journal of Diabetes Investigation","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143717816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Severe insulin-deficient diabetes is at the opposite end of the neuropathy spectrum to mild aged-related diabetes.","authors":"Brian C Callaghan, Ranjit Mohan Anjana, Lavanya Muthukumar, Evan L Reynolds, Jebarani Saravanan, Mani Arun Vignesh, Aswin Mukundan, Eva L Feldman, Viswanathan Mohan","doi":"10.1111/jdi.70033","DOIUrl":"https://doi.org/10.1111/jdi.70033","url":null,"abstract":"<p><p>The effect of diabetes subtypes on neuropathy prevalence and metabolic drivers of this relationship are unknown. Using electronic medical records from 50 diabetes care centers in eight states of India with biothesiometer and complete phenotyping data on 22,348 patients, we determined neuropathy prevalence stratified by India-specific diabetes subtypes and evaluated associations with neuropathy (biothesiometer). Neuropathy prevalence was highest in severe insulin-deficient diabetes (SIDD; 25.5%), followed by insulin-resistant obese diabetes (IROD; 21.8%), mild age-related diabetes (MARD; 18.9%), and combined insulin-resistant and deficient diabetes (CIRDD; 17.3%, P = <0.001). HbA1c (odds ratio [OR]: 1.19, 1.16-1.21), diabetes duration (OR: 1.04, 1.04-1.05), and waist circumference (OR: 1.01, 1.01-1.02) were associated with neuropathy. SIDD (OR: 2.23, 2.01-2.47), CIRDD (OR: 1.89, 1.69-2.11), and IROD (OR: 1.84, 1.66-2.04) had increased neuropathy compared to MARD. In India, SIDD patients are more likely to have neuropathy compared to MARD patients likely from longer diabetes duration and higher HbA1c; therefore, interventions should focus on hyperglycemia. Interventions in CIRDD and IROD patients should likely address obesity as well.</p>","PeriodicalId":190,"journal":{"name":"Journal of Diabetes Investigation","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143717817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to the comment of Wasti on \"Association between severity of diabetic complications and risk of cancer in middle-aged patients with type 2 diabetes\".","authors":"Yao-Hsien Tseng, Pau-Chung Chen","doi":"10.1111/jdi.70034","DOIUrl":"https://doi.org/10.1111/jdi.70034","url":null,"abstract":"","PeriodicalId":190,"journal":{"name":"Journal of Diabetes Investigation","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143707937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Blood pressure and the risk of diabetes: A longitudinal observational study based on Chinese individuals.","authors":"Zhiqiang Zhang, Hejun Chen, Lei Chen, Wenyan Liang, Tenglong Hu, Na Sun, Yangyu Zhao, Xiqing Wei","doi":"10.1111/jdi.70029","DOIUrl":"https://doi.org/10.1111/jdi.70029","url":null,"abstract":"<p><strong>Background: </strong>With lifestyle changes, the incidence of diabetes has been steadily increasing, and hypertension remains a significant risk factor impacting cardiovascular health. Understanding the potential effects of blood pressure on diabetes risk is, therefore, crucial. This study aims to comprehensively explore the relationship between blood pressure and diabetes risk.</p><p><strong>Methods: </strong>A total of 211,809 individuals undergoing health check-ups were included in this analysis. Participants were divided into four groups based on the quartiles of systolic and diastolic blood pressure, with the primary outcome being the incidence of new-onset diabetes.</p><p><strong>Results: </strong>Over an average follow-up period of 3.1 years (±0.94 years), 3,000 men (1.42%) and 1,173 women (0.55%) were newly diagnosed with diabetes. Multivariable Cox regression analysis demonstrated that blood pressure is an independent predictor of new-onset diabetes (systolic blood pressure HR 1.07 per SD increase, 95% CI: 1.01-1.12, P for trend <0.001; diastolic blood pressure HR 1.11 per SD increase, 95% CI: 1.06-1.17, P for trend 0.001). The optimal cutoff for systolic blood pressure in predicting new-onset diabetes was found to be 123 mmHg (area under the curve 0.7014, sensitivity 0.65, specificity 0.64), which was superior to the predictive efficacy of diastolic blood pressure (area under the curve 0.6645, sensitivity 0.63, specificity 0.62). Subgroup analyses indicated that the risk of blood pressure-related diabetes was significantly higher in middle-aged individuals compared to older adults (P for interaction <0.05). Additionally, women showed a higher risk of systolic blood pressure-related diabetes than men, and normal-weight individuals exhibited a higher risk than those with obesity (P for interaction <0.05).</p><p><strong>Conclusions: </strong>This cohort study within a Chinese population highlights that, after adjusting for other confounding factors, blood pressure is an independent risk factor for diabetes. This association is particularly pronounced among middle-aged individuals, women, and those of normal weight. Moreover, systolic blood pressure demonstrates superior predictive efficacy for diabetes compared to diastolic blood pressure.</p>","PeriodicalId":190,"journal":{"name":"Journal of Diabetes Investigation","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143690713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of the Japanese gestational diabetes mellitus diagnostic strategy during the coronavirus disease 2019 pandemic using DREAMBee study data.","authors":"Yoshifumi Kasuga, Kei Miyakoshi, Maki Yokoyama, Noriyuki Iwama, Raishi Ichikawa, Hiroshi Yamashita, Ichiro Yasuhi, Asami Ito, Hirohito Sone, Atsuko Abiko, Shinichi Harashima, Maki Kawasaki, Naoko Arata, Shiori Sato, Yuko Iimura, Masako Waguri, Haruna Kawaguchi, Naoki Masaoka, Yoshiyuki Nakajima, Yuji Hiramatsu, Takashi Sugiyama","doi":"10.1111/jdi.70031","DOIUrl":"https://doi.org/10.1111/jdi.70031","url":null,"abstract":"<p><strong>Aims/introduction: </strong>We evaluated a simple diagnostic gestational diabetes mellitus (GDM) strategy (Japanese COVID-19 GDM strategy) published by the Japanese Society of Diabetes and Pregnancy using GDM group data from the Diabetes and Pregnancy Outcomes for Mother and Baby (DREAMBee) study.</p><p><strong>Materials and methods: </strong>The study included 803 mothers with GDM diagnosed after 24 gestational weeks using an oral glucose tolerance test and 1,356 with normal glucose tolerance (NGT) from the DREMBee study. They were reclassified by the Japanese COVID-19 GDM strategies (COVID-19 GDM and COVID-19 NGT) using glycated hemoglobin (HbA1c) and random plasma glucose or fasting plasma glucose (FPG) levels. We evaluated the usefulness of the Japanese COVID-19 GDM strategy and investigated the parameters for diagnosing GDM managed with insulin therapy.</p><p><strong>Results: </strong>Participants (n = 2,159) were assigned to COVID-19 GDM (n = 413) and COVID-19 NGT (n = 1,746) groups. The sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of the Japanese COVID-19 GDM strategy were 35.4, 90.5, 68.9, and 70.3%, respectively. When the risk factors for insulin therapy were analyzed using a regression model, HbA1c and FPG levels were risk factors for GDM with insulin therapy (P < 0.0001). The cut-off value of HbA1c was 5.4% (sensitivity, 0.69; specificity, 0.66; PPV, 0.11; NPV, 0.97), and that of FPG was 86 mg/dL (sensitivity, 0.60; specificity, 0.77; PPV, 0.16; NPV, 0.96).</p><p><strong>Conclusions: </strong>The Japanese COVID-19 GDM strategy for GDM diagnosis after 24 weeks of gestation might be useful in emergency situations. However, further analysis of GDM outcomes diagnosed using this approach is necessary.</p>","PeriodicalId":190,"journal":{"name":"Journal of Diabetes Investigation","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143690710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of luseogliflozin on liver fibrosis differs depending on alcohol consumption in patients with type 2 diabetes.","authors":"Hiroyuki Ito, Ryota Someya, Tomoko Koyanagi, Chiaki I, Shun Miura, Suzuko Matsumoto, Hideyuki Inoue, Shinichi Antoku, Tomoko Yamasaki, Toshiko Mori, Michiko Togane","doi":"10.1111/jdi.70032","DOIUrl":"https://doi.org/10.1111/jdi.70032","url":null,"abstract":"<p><strong>Aim: </strong>Changes in FIB-4 levels after the initiation of luseogliflozin therapy were compared between patients with type 2 diabetes according to the presence or absence of alcohol consumption.</p><p><strong>Methods: </strong>A total of 192 patients with type 2 diabetes who continued luseogliflozin therapy for over 12 months were retrospectively investigated. The primary outcome was the change in FIB-4. The secondary outcomes were changes in HbA1c, body weight, and serum albumin concentration. A current drinker was defined as an individual consuming >20 g ethanol equivalent/day. Patients were classified according to their risk of developing liver fibrosis into the low-risk (FIB-4 < 1.3) and intermediate/high-risk (FIB-4 ≥ 1.3) groups.</p><p><strong>Results: </strong>In the low-risk group, while FIB-4 increased dramatically from 0.91 ± 0.30 at the baseline to 1.14 ± 0.34 at 12 months in drinkers (n = 27), non-drinkers (n = 79) showed no significant change (0.87 ± 0.22-0.91 ± 0.26). In the intermediate/high-risk group (n = 63), although the FIB-4 in drinkers (n = 23) showed no significant change (2.18 ± 1.00-2.16 ± 0.93), it significantly decreased from 2.10 ± 0.87 to 1.80 ± 0.68 in non-drinkers (n = 63). In both the low- and intermediate/high-risk groups, HbA1c and body weight significantly decreased in both drinkers and non-drinkers. Serum albumin concentrations significantly increased in both drinkers and non-drinkers in the low-risk group. Although serum albumin concentration did not significantly change in drinkers, it dramatically increased in non-drinkers in the intermediate/high-risk group.</p><p><strong>Conclusions: </strong>HbA1c levels and body weight decreased in patients with type 2 diabetes after initiating luseogliflozin therapy, regardless of drinking habits. However, it is desirable to limit alcohol consumption when considering its effects on liver fibrosis.</p>","PeriodicalId":190,"journal":{"name":"Journal of Diabetes Investigation","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143690743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cordycepin ameliorates diabetic nephropathy injury by activating the SLC7A11/GPX4 pathway.","authors":"Bing Wu, Jing Wang, Xiaohui Yan, Gang Jin, Qiong Wang","doi":"10.1111/jdi.14407","DOIUrl":"https://doi.org/10.1111/jdi.14407","url":null,"abstract":"<p><strong>Background: </strong>Cordycepin (CRD) has been identified to alleviate diabetes-induced injuries and complications including diabetic nephropathy (DN). Here, this work focused on probing the specific effects and potential mechanisms of CRD on DN progression.</p><p><strong>Methods: </strong>High glucose (HG)-induced mouse podocyte cell line (MPC5) was used for in vitro functional analyses. Cell proliferation and apoptosis were determined using cell counting kit-8 assay, 5-ethynyl-2'-deoxyuridine assay, and flow cytometry, respectively. ELISA analysis detected inflammatory factors. Cell ferroptosis was assessed by measuring the levels of Fe2+, glutathione, reactive oxygen species, and malonaldehyde.</p><p><strong>Results: </strong>CRD treatment suppressed HG-induced apoptosis, inflammation, and ferroptosis in podocytes. CRD treatment elevated SLC7A11 and GPX4 expression in HG-treated podocytes. The overexpression of SLC7A11 or GPX4 suppressed HG-evoked apoptosis, inflammation, and ferroptosis in podocytes. Moreover, the silencing of SLC7A11 or GPX4 abolished the protective effects of CRD on HG-treated podocytes. Moreover, CRD ameliorated renal structure injury and inflammation in STZ-induced diabetic mice by modulating SLC7A11 or GPX4 expression.</p><p><strong>Conclusions: </strong>Cordycepin suppressed HG-induced apoptosis, inflammation, and ferroptosis in podocytes in vitro, and ameliorated renal injury and inflammation in STZ-induced diabetic mice by activating the SLC7A11/GPX4 pathway.</p>","PeriodicalId":190,"journal":{"name":"Journal of Diabetes Investigation","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143690652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inhibition of LINC00707/miR-223-3p/FKBP5 axis has a protective effect on diabetic kidney disease.","authors":"Hongzhen Ye, Yiting Chen, Hong Xia, Lingbo Lv, Lijun Gao","doi":"10.1111/jdi.70025","DOIUrl":"https://doi.org/10.1111/jdi.70025","url":null,"abstract":"<p><strong>Objective: </strong>Research indicates that LINC00707 is abnormally expressed in patients suffering from diabetic kidney disease (DKD). Nevertheless, the precise role of LINC00707 in the context of DKD remains enigmatic and warrants further investigation.</p><p><strong>Methods: </strong>Initially, RT-qPCR was employed to assess the expression levels of LINC00707 in patients with DKD. Subsequently, we cultured glomerular podocytes under high-glucose conditions. The effects of LINC00707 on cell proliferation, apoptosis, podocyte functionality (Podocin, Nephrin, and CD2AP), oxidative stress (MDA and SOD), and inflammatory responses (IL-1β, IL-6, and TNF-α) were evaluated using CCK-8, flow cytometry, RT-qPCR, and ELISA assays. Finally, we co-regulated LINC00707 alongside its downstream targets to elucidate the molecular mechanisms by which LINC00707 influences podocyte injury.</p><p><strong>Results: </strong>LINC00707 is abnormally upregulated in DKD patients. Furthermore, a notable inverse correlation has been observed between LINC00707 levels and renal function in these patients. Upon downregulating LINC00707, we observed an increase in cellular proliferative activity, alongside elevated levels of Podocin, Nephrin, and CD2AP. Concurrently, the reduction of LINC00707 was associated with decreased levels of MDA, as well as proinflammatory cytokines. Significantly, the inhibition of miR-223-3p was found to reverse these observed effects. Further investigation revealed that miR-223-3p directly targets FK506-binding protein 5 (FKBP5).</p><p><strong>Conclusions: </strong>Inhibition of LINC00707 may reduce podocyte damage during hyperglycemia by targeting miR-223-3p/FKBP5.</p>","PeriodicalId":190,"journal":{"name":"Journal of Diabetes Investigation","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143668666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Machine learning-based risk prediction model for neuropathic foot ulcers in patients with diabetic peripheral neuropathy.","authors":"Ge Shi, Zhenxuan Gao, Ze Zhang, Quanyu Jin, Sitong Li, Jiaxin Liu, Lei Kou, Abudurezhake Aerman, Wenqiang Yang, Qi Wang, Furong Cai, Li Zhang","doi":"10.1111/jdi.70010","DOIUrl":"https://doi.org/10.1111/jdi.70010","url":null,"abstract":"<p><strong>Background: </strong>Diabetic peripheral neuropathy (DPN) is a common chronic complication of diabetes, marked by symptoms like hyperalgesia, numbness, and swelling that impair quality of life. Nerve conduction abnormalities in DPN significantly increase the risk of neuropathic foot ulcers (NFU), which can progress rapidly and lead to severe outcomes, including infection, gangrene, and amputation. Early prediction of NFU in DPN patients is crucial for timely intervention.</p><p><strong>Methods: </strong>Clinical data from 400 DPN patients treated at the China-Japan Friendship Hospital (September 2022-2024) were retrospectively analyzed. Data included medical histories, physical exams, biochemical tests, and imaging. After feature selection and data balancing, the dataset was split into training and validation subsets (8:2 ratio). Six machine learning algorithms-random forest, decision tree, logistic regression, K-nearest neighbor, extreme gradient boosting, and multilayer perceptron-were evaluated using k-fold cross-validation. Model performance was assessed via accuracy, precision, recall, F1 score, and AUC. The SHAP method was employed for interpretability.</p><p><strong>Results: </strong>The multilayer perceptron model showed the best performance (accuracy: 0.875; AUC: 0.901). SHAP analysis highlighted triglycerides, high-density lipoprotein cholesterol, diabetes duration, age, and fasting blood glucose as key predictors.</p><p><strong>Conclusions: </strong>A machine learning-based prediction model using a multilayer perceptron algorithm effectively identifies DPN patients at high NFU risk, offering clinicians an accurate tool for early intervention.</p>","PeriodicalId":190,"journal":{"name":"Journal of Diabetes Investigation","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143672906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Single sural nerve response: A reliable and practical method for diagnosis of diabetic peripheral neuropathy in children with type 1 diabetes.","authors":"Hüseyin Bahadır Şenol, Özge Yıldırım Şalbaş, Elif Naz Kadem, Mustafa Halk, Ayşe İpek Polat, Adem Aydın, Ayşe Semra Hız, Korcan Demir, Uluç Yiş","doi":"10.1111/jdi.70030","DOIUrl":"https://doi.org/10.1111/jdi.70030","url":null,"abstract":"<p><strong>Objectives: </strong>Type 1 diabetes mellitus (T1DM) is a significant global health issue, particularly due to its association with microvascular complications such as diabetic peripheral neuropathy (DPN). Sensory nerves in the lower extremities are primarily affected by DPN, with the sural nerve being particularly impacted. The conventional method for diagnosing DPN involves evaluating four motor and four sensory nerves in the upper and lower extremities. Motor tests use dual-point high-intensity stimulation to elicit a compound muscle action potential, while sensory tests apply a single, lower-intensity stimulus to assess depolarized nerve fibers. The aim of this study was to define the efficacy of using a single sural nerve response for the diagnosis of DPN in pediatric T1DM patients compared to the conventional method.</p><p><strong>Methods: </strong>This retrospective study analyzed data from 242 patients, including 204 with T1DM and 38 controls. For T1DM patients, we evaluated risk factors for DPN, including age, gender, hemoglobin A1c levels, lipid parameters, and body mass index. Nerve conduction studies were evaluated in both groups.</p><p><strong>Results: </strong>The examination of a single sural nerve achieved a sensitivity of 83.3% and a specificity of 97.2% in diagnosing DPN. Multivariate logistic regression analysis identified HbA1c level as the only significant predictor of DPN. Comparison of sural nerve responses between non-neuropathic T1DM patients and the control group indicated pre-electrophysiological nerve abnormalities within the T1DM cohort.</p><p><strong>Conclusions: </strong>Evaluation of a single sural nerve response in pediatric T1DM patients can replace conventional nerve studies. The study supports the use of point-of-care devices for DPN detection, potentially simplifying and enhancing clinical practice.</p>","PeriodicalId":190,"journal":{"name":"Journal of Diabetes Investigation","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143661818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}