Journal of Diabetes Investigation最新文献

{"title":"Author's reply to the \"Comment on 'Concomitant use of metformin and proton pump inhibitors increases vitamin B12 deficiency risk in type 2 diabetes'\".","authors":"Choungwon Jung, Soyoung Park, Hyunah Kim","doi":"10.1111/jdi.70125","DOIUrl":"https://doi.org/10.1111/jdi.70125","url":null,"abstract":"","PeriodicalId":190,"journal":{"name":"Journal of Diabetes Investigation","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144648091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between medication use and non-attendance (missed appointment) from primary care visits among people with type 2 diabetes: The Japan Diabetes Outcome Intervention Trial-2 Large-Scale Trial 006 (J-DOIT2-LT006).","authors":"Yusuke Hikima, Ryotaro Bouchi, Yasuaki Hayashino, Atsushi Goto, Hikari Suzuki, Katsuya Yamazaki, Kazuo Izumi, Masaomi Nangaku, Mitsuhiko Noda","doi":"10.1111/jdi.70121","DOIUrl":"https://doi.org/10.1111/jdi.70121","url":null,"abstract":"<p><strong>Aims/introduction: </strong>To clarify the relationship between medication use and primary care visit non-attendance (missed appointment) among people with type 2 diabetes.</p><p><strong>Materials and methods: </strong>Data of 2,200 patients registered in the Japan Diabetes Outcome Intervention Trial-2 Large-Scale trial were reviewed. The intervention group received multifaceted interventions encouraging regular visits. The hazard ratios (HR) and 95% confidence intervals (CI) of oral medications relative to not taking any oral medications were estimated using the Cox proportional hazards model, adjusted for district medical association ID, intervention, insulin usage, age, sex, and HbA1c. We also investigated whether the HRs differed based on the oral medication type. Furthermore, we divided the intervention and control groups into four groups based on medication use (taking/not taking oral medications and insulin therapy) and performed survival analysis for each group.</p><p><strong>Results: </strong>The HRs (95% CI) for oral medication use relative to not taking oral medications and for insulin use relative to not receiving insulin therapy were 0.178 (0.104-0.305) and 0.725 (0.378-1.352), respectively. Regardless of the type of oral medication, non-attendance was lower in the groups taking oral medications. The HRs (95% CI) in the groups taking only oral hypoglycemic agents, only other drugs, and both relative to no oral medication were 0.229 (0.126-0.417), 0.235 (0.112-0.494), and 0.148 (0.084-0.260), respectively. Only in the control group, non-attendance was more frequent with no medications than with oral medications, regardless of insulin (P < 0.01, respectively).</p><p><strong>Conclusions: </strong>Our findings suggest that taking oral medications might be important to prevent non-attendance among people with type 2 diabetes.</p>","PeriodicalId":190,"journal":{"name":"Journal of Diabetes Investigation","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144615597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A nomogram incorporating clinical and laboratory indicators for predicting metabolic dysfunction-associated fatty liver disease in newly diagnosed type 2 diabetes patients.","authors":"Tingting Li, Yao Wang, Shengnan Zhao, Yuliang Cui, Zhenzhen Qu","doi":"10.1111/jdi.70112","DOIUrl":"https://doi.org/10.1111/jdi.70112","url":null,"abstract":"<p><strong>Aims: </strong>To develop and validate a nomogram model based on clinical and laboratory parameters to predict the risk of metabolic dysfunction-associated fatty liver disease (MAFLD) in the early stage of type 2 diabetes.</p><p><strong>Materials and methods: </strong>We performed this study among 883 inpatients with new-onset type 2 diabetes, and the data were divided randomly into training and validation groups. The logistic regression method was used to identify the independent risk factors of MAFLD, and a nomogram was established according to the logistic regression analysis and these selected parameters. The discrimination, calibration, and clinical utility of the nomogram were measured by receiver operating characteristic curve analysis, calibration curves, and decision-curve analysis, respectively.</p><p><strong>Results: </strong>Eight variables were identified and included in the nomogram (body mass index, alanine aminotransferase, triglyceride, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, fasting plasma glucose, urea nitrogen and serum uric acid). The value of the area under the receiver operating characteristic (ROC) curve was 0.898 for the training group and 0.92 for the validation group. The calibration plots indicated that this model had good accuracy, and the decision-curve analysis revealed high-clinical practicability of the nomogram.</p><p><strong>Conclusions: </strong>This study established a convenient and practical nomogram model, which can be used as an easy-to-use tool to evaluate the risk of MAFLD among patients with newly diagnosed T2DM.</p>","PeriodicalId":190,"journal":{"name":"Journal of Diabetes Investigation","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144606951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of red blood cell distribution width/albumin ratio with renal prognosis among patients with type 2 diabetes mellitus: A retrospective cohort study.","authors":"Hiroshi Kimura, Kenichi Tanaka, Hirotaka Saito, Sakumi Kazama, Michio Shimabukuro, Koichi Asahi, Tsuyoshi Watanabe, Junichiro James Kazama","doi":"10.1111/jdi.70118","DOIUrl":"https://doi.org/10.1111/jdi.70118","url":null,"abstract":"<p><strong>Introduction: </strong>The red blood cell distribution width/albumin ratio (RAR) has been reported to be a prognostic marker for adverse clinical outcomes. However, there is limited data on the relationship between RAR and renal function in patients with type 2 diabetes mellitus (T2DM). This study aimed to investigate the effect of RAR on renal prognosis in patients with T2DM.</p><p><strong>Research design and methods: </strong>This retrospective cohort study included 907 patients with T2DM enrolled in the Fukushima Cohort Study, divided into two groups (high and low RAR) according to their baseline RAR. The association between RAR and renal events was assessed using Kaplan-Meier curves and multivariate Cox regression analyses. Receiver operating characteristic (ROC) curve analyses, as well as the net reclassification index (NRI) and integrated discrimination improvement (IDI), examined the differences between RAR and red blood cell distribution width (RDW) alone.</p><p><strong>Results: </strong>The high RAR group showed an increased risk of renal events in the Kaplan-Meier curve analysis. Compared with the low RAR group, the high RAR group showed an increased risk of renal events (adjusted hazard ratio [HR]: 3.40, 95% confidence interval: 1.76-6.57). RAR exhibited a significantly higher area under the curve (AUC), NRI, and IDI for renal events than RDW.</p><p><strong>Conclusion: </strong>We observed an association between high RAR and worse renal outcomes in patients with T2DM. RAR assessment may have potential utility as a predictive tool for renal prognosis.</p>","PeriodicalId":190,"journal":{"name":"Journal of Diabetes Investigation","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144582739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The prevalence of hepatitis B infection and anti-HCV antibody in patients with diabetes mellitus.","authors":"Malihe Naderi, Seyed Masoud Hosseini, Vahideh Hamidi, Abdolvahab Moradi","doi":"10.1111/jdi.70064","DOIUrl":"https://doi.org/10.1111/jdi.70064","url":null,"abstract":"<p><strong>Background: </strong>The liver's role in glucose metabolism and hormone regulation links liver infections to diabetes mellitus. Understanding this interaction is crucial for managing diabetes in affected patients.</p><p><strong>Objective: </strong>Golestan Province has the highest incidence of hepatitis B virus (HBV) infection in the country. The current research aimed to assess the prevalence of HBV infection and anti-HCV antibodies among diabetic patients in the region, providing insights to improve disease management and prevention.</p><p><strong>Methods: </strong>Data from 31,803 diabetic patients, collected (2019-2023) from the NAB system at Golestan University of Medical Sciences, were used to evaluate the co-occurrence of HBV infection and anti-HCV antibodies in them. Also, this study analyzed the co-occurrence of diabetes in three/two-generation CHB (Chronic Hepatitis B) patients, and recovered patients, demographic factors, liver enzyme, and viral DNA levels. Binary logistic regression was applied to identify factors associated with diabetes.</p><p><strong>Results: </strong>HBsAg and anti-HCV antibody positivity were found in 2.52% and 0.53% of diabetic individuals, respectively. Diabetic patients with HBV infection (P-value = 0.003) or anti-HCV positivity (P-value = 0.008) had significantly lower BMIs. HBV prevalence was higher among married individuals (78.4%, P-value = 0.01) and rural residents (61.7%, P-value = 0.3). Diabetic patients with two or three generations of HBV/diabetes had higher liver enzyme levels and HBV viral loads compared to those without diabetes (P-value < 0.05).</p><p><strong>Conclusions: </strong>In individuals with diabetes, compared to those without the disease, there was a correlation between HBV infections and altered liver function indicators, as well as HBV viral load. Additionally, familial susceptibility to HBV infection or anti-HCV antibody positivity was significant.</p>","PeriodicalId":190,"journal":{"name":"Journal of Diabetes Investigation","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144582741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Household income modifies the association between social capital and gestational diabetes mellitus in Japan: Results from TMM BirThree Cohort Study.","authors":"Koichi Sakakibara, Tomoki Kawahara, Nobutoshi Nawa, Keiko Murakami, Hisashi Ohseto, Ippei Takahashi, Akira Narita, Taku Obara, Mami Ishikuro, Masatsugu Orui, Aoi Noda, Genki Shinoda, Satoshi Nagaie, Soichi Ogishima, Junichi Sugawara, Shigeo Kure, Kengo Kinoshita, Atsushi Hozawa, Nobuo Fuse, Gen Tamiya, Wendy L Bennett, Shinichi Kuriyama, Takeo Fujiwara, Pamela J Surkan","doi":"10.1111/jdi.70101","DOIUrl":"https://doi.org/10.1111/jdi.70101","url":null,"abstract":"<p><strong>Introduction: </strong>While social capital can prevent diabetes, these benefits can be heterogeneous with respect to socioeconomic status. We investigated the association between social capital and gestational diabetes mellitus (GDM) while examining effect modification by household income.</p><p><strong>Materials and methods: </strong>We conducted a secondary data analysis using the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study carried out between July 2013 and March 2017. Social capital (mutual aid, social trust, informal social control, collective action) and covariates were self-reported, while GDM diagnosis and other medical and physiological information were obtained from medical records. To assess the association between social capital and GDM, we conducted logistic regression models. We further tested for interactions between social capital and household income as well as stratified the models by income.</p><p><strong>Results: </strong>Among 20,339 study participants, 700 (3.4%) were diagnosed with GDM. Multivariable logistic regression models found that social trust and collective action were associated with lower GDM prevalence, even after adjustment of covariates. When stratifying household income, however, social capital was significantly associated with the reduced risks of GDM only among participants with higher household income (OR: 0.90, 95% CI: 0.85-0.97). No significant association was observed among those with lower household income.</p><p><strong>Conclusions: </strong>The health benefit of social capital on GDM prevalence was heterogeneous, and the protective effect of social capital on GDM was found only among women with higher household income. The differential impact of social capital on GDM highlights the need for targeted interventions addressing structural health inequities.</p>","PeriodicalId":190,"journal":{"name":"Journal of Diabetes Investigation","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144590028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the editor in response to \"Glycemic control is worse in rural compared to urban type 2 diabetes in Bangladesh, irrespective of food security status\".","authors":"Jie Chen, Yindan Song","doi":"10.1111/jdi.70119","DOIUrl":"https://doi.org/10.1111/jdi.70119","url":null,"abstract":"","PeriodicalId":190,"journal":{"name":"Journal of Diabetes Investigation","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144582740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification and verification of feature biomarkers associated with CD14⁺ monocytes in type 1 diabetes.","authors":"Jin Huang, Yu Ding, Tong Yu, Shanshan Chen, Jinrong He, Lifeng Shi, Xiuling Wang","doi":"10.1111/jdi.70117","DOIUrl":"https://doi.org/10.1111/jdi.70117","url":null,"abstract":"<p><strong>Aims/introduction: </strong>Monocytes contribute to the immune dysregulation of pancreatic islets in Type 1 diabetes mellitus (T1D). This study aims to identify the feature genes of CD14⁺ monocytes in T1D, which might offer a new perspective on immune dysregulation and potential therapeutic targets in T1D.</p><p><strong>Materials and methods: </strong>Two CD14⁺ monocyte-related datasets were integrated for DEGs and WGCNA analysis. LASSO and SVM-RFE machine learning algorithms were applied for further screening of feature genes. Subsequent nomogram model and single-gene GSEA analysis were performed. The experiments in vitro and in vivo were conducted for the verification and functional investigation of the feature gene.</p><p><strong>Results: </strong>Eleven up-regulated and five down-regulated DEGs in T1D samples were identified in the integrated dataset. WGCNA analysis obtained 13 gene co-expression modules in which the yellow module had a significantly positive correlation with the T1D phenotype, and the magenta module had a negative correlation. Thirteen intersecting genes between DEGs and WGCNA gene modules were subjected to LASSO and SVM-RFE machine learning, and the feature gene ID1 was eventually screened out and verified. In terms of the T1D diagnostic model, the calibration curve and ROC curve displayed high predictive accuracy and effectiveness. Single-gene GSEA analysis revealed that high ID1 was associated with the IL1/IL1R/JNK signaling pathway gene set. The increased ID1 was verified in high glucose-treated THP-1 cells and T1D subjects, and the deficiency of ID1 impaired the expression of the inflammatory cytokine IL6.</p><p><strong>Conclusions: </strong>We had identified ID1 as the feature gene of CD14⁺ monocytes, which exhibited the ability for diagnosis and prediction of T1D.</p>","PeriodicalId":190,"journal":{"name":"Journal of Diabetes Investigation","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144566861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical value of high-frequency ultrasound and serum miR-92a-3p in diabetic peripheral neuropathy.","authors":"Chunmei Qiao, Zhenjiao Liu, Boran Wang, Xin Wang, Zifu Zhao, Hui Wang, Xiaolei Wang","doi":"10.1111/jdi.70110","DOIUrl":"https://doi.org/10.1111/jdi.70110","url":null,"abstract":"<p><strong>Aims/introduction: </strong>Cross-sectional area (CSA) by high-frequency ultrasound (HF-US) detects morphologic changes in neuropathy. microRNA (miR)-92a-3p is linked to diabetes and nerve damage. Our study evaluated the diagnostic use of CSAs along with miR-92a-3p in diabetic peripheral neuropathy (DPN) and its relationship to the condition.</p><p><strong>Materials and methods: </strong>A total of 172 patients were enrolled, comprising 89 with DPN and 83 T2DM cases without DPN. Real-time quantitative polymerase chain reaction (RT-qPCR) was utilized to quantify serum miR-92a-3p levels. HF-US detected CSA in the median, ulnar, and tibial nerves. Logistic regression analyzed potential risk factors for DPN occurrence and severity. Receiver operating characteristic curves assessed the diagnostic significance of miR-92a-3p and CSAs for DPN. Pearson coefficients evaluated the correlation between the Toronto Clinical Scoring System (TCSS) score and miR-92a-3p or CSAs.</p><p><strong>Results: </strong>DPN patients had significantly higher serum miR-92a-3p levels and CSAs of the median, tibial, and ulnar nerves than T2DM patients. Moreover, miR-92a-3p and CSAs were risk factors for DPN. When combined, they yielded an AUC of 0.891, with 80.90% sensitivity and 91.57% specificity, accurately identifying DPN patients. Furthermore, miR-92a-3p and CSAs correlated with TCSS score and were higher in moderate-to-severe patients with DPN than in mild patients with DPN. Finally, miR-92a-3p combined with CSAs predicted moderate-to-severe DPN with 91.67% sensitivity and 85.37% specificity.</p><p><strong>Conclusions: </strong>Serum miR-92a-3p and CSAs of median, ulnar, and tibial nerves are elevated in DPN patients. Their combination has high diagnostic significance in identifying DPN in T2DM patients and assessing its severity.</p>","PeriodicalId":190,"journal":{"name":"Journal of Diabetes Investigation","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144558627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hyperglycemia as an atypical finding of malignant hyperthermia: A case report and literature review.","authors":"Huai-Jhih Sun, Yuan-Yi Chia, Yung-Yun Huang, Jun-Chen Sun, Chun-Hsien Wen","doi":"10.1111/jdi.70120","DOIUrl":"https://doi.org/10.1111/jdi.70120","url":null,"abstract":"<p><p>Malignant hyperthermia (MH) is a rare but life-threatening disorder induced by volatile anesthetics or depolarizing muscle relaxants. Studies have reported the increased prevalence of hyperglycemia among patients susceptible to MH. Herein, we present the case of a 13-month-old toddler who had successfully undergone dextro-transposition of the great arteries and required main and bilateral pulmonary artery augmentation because of residual pulmonary atresia. The patient exhibited atypical manifestations of MH including hyperglycemia with an inadequate insulin response during the perioperative period. The hyperglycemia resolved following administration of dantrolene, the antidote for MH. Research has associated intracellular calcium leaks with reduced glucose storage in human muscle. Metabolic alterations in patients susceptible to MH may predispose them to hyperglycemia during acute MH episodes.</p>","PeriodicalId":190,"journal":{"name":"Journal of Diabetes Investigation","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144551522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}