Organic & Biomolecular Chemistry最新文献

1,8-Naphthalimide derivatives as small molecules with multi-applications in chemistry and biology. 1,8-萘酰亚胺小分子衍生物在化学和生物学上的广泛应用。

IF 2.9 3区化学

Organic & Biomolecular Chemistry Pub Date : 2025-06-17 DOI: 10.1039/d5ob00657k

Sanaullah, Krzysztof Walczak

{"title":"1,8-Naphthalimide derivatives as small molecules with multi-applications in chemistry and biology.","authors":"Sanaullah, Krzysztof Walczak","doi":"10.1039/d5ob00657k","DOIUrl":"https://doi.org/10.1039/d5ob00657k","url":null,"abstract":"1,8-Naphthalimide and its derivatives have attracted attention from scientists because of their ease of synthesis, flexible structural modifications, and notable optical properties such as good fluorescence, large Stokes shifts, high quantum yields, unique photostability, and well documented biological activities. This review focuses on the modifications at the imide nitrogen and the naphthalene core of 1,8-naphthalimides through nucleophilic substitution reactions and examines their effect on the chemical, photophysical, and biological properties of these compounds. Furthermore, the wide range of applications of these compounds in the fields of chemistry and biology have also been discussed in detail. In terms of chemistry, their efficient electron transporting capabilities support their use in the development of organic light-emitting diodes (OLEDs) and high performance dyes and as ligands in the synthesis of metal complexes. In the field of biology, their outstanding capabilities in cell imaging and DNA intercalation along with their function as unique fluorescent probes underscores their utility in molecular diagnostics and targeted therapeutics. This review critically examines and bridges the diverse applications of 1,8-naphthalimides and their derivatives across the chemical and biological sciences over the past fifteen years.","PeriodicalId":96,"journal":{"name":"Organic & Biomolecular Chemistry","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144309225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Selective monophosphorylation of cyclic diols and polyols via hemiboronic acid catalysis. 半硼酸催化环二醇和多元醇的选择性单磷酸化。

IF 2.9 3区化学

Organic & Biomolecular Chemistry Pub Date : 2025-06-16 DOI: 10.1039/d5ob00813a

Geneviève F O'Keefe, Dawson J Konowalchuk, Dalida L Akl, Dennis G Hall

引用次数: 0

Selective hydrogen isotope exchange on sulfonamides, sulfilimides and sulfoximines by electrochemically generated bases. 电化学生成的碱基对磺胺类、亚砜酰亚胺类和亚砜亚胺类的选择性氢同位素交换。

IF 2.9 3区化学

Organic & Biomolecular Chemistry Pub Date : 2025-06-13 DOI: 10.1039/d5ob00799b

Carla Marie Stork, Elisabeth Glöckler, Volker Derdau, Philipp Schnieders, Siegfried R Waldvogel

引用次数: 0

Harnessing the reactivity of captodative radicals: photocatalytic α-pyridination of glycyl derivatives through reversible radical coupling. 利用俘获自由基的反应性：通过可逆自由基偶联光催化α-吡啶化甘酰基衍生物。

IF 2.9 3区化学

Organic & Biomolecular Chemistry Pub Date : 2025-06-13 DOI: 10.1039/d5ob00675a

Ken Yamazaki, Shuta Akimoto, Tomoya Miura

引用次数: 0

Discovery of a plant-like tridomain bifunctional syn-abieta-7,13-diene synthase in Streptomyces. 链霉菌中一种类植物三结构域双功能syn-abieta-7,13-二烯合成酶的发现。

IF 2.9 3区化学

Organic & Biomolecular Chemistry Pub Date : 2025-06-13 DOI: 10.1039/d5ob00724k

Caitlin A McCadden, Diana P Łomowska-Keehner, Tracy Qu, Jordan Nafie, Tyler A Alsup, Jeffrey D Rudolf

引用次数: 0

Highly enantioselective hydrogenation of 2-pyridyl ketones enabled by Ir-f-phamidol catalyst. 2-吡啶酮的高对映选择性加氢。

IF 2.9 3区化学

Organic & Biomolecular Chemistry Pub Date : 2025-06-12 DOI: 10.1039/d5ob00833f

Lei Xu, Gen-Qiang Chen, Xumu Zhang

引用次数: 0

Direct catalytic synthesis of β-acylamino cyclobutanones via three-component Mannich reactions. 三组分曼尼希反应直接催化合成β-酰基氨基环丁酮。

IF 2.9 3区化学

Organic & Biomolecular Chemistry Pub Date : 2025-06-12 DOI: 10.1039/d4ob01543f

Bence S Nagy, Fegyverneki Dániel, Péter Szalai, András Kotschy, Márió Gyuris

引用次数: 0

Indole-2-carboxamide: a versatile synthetic handle for the synthesis of diversely substituted polycyclic indole structures. 吲哚-2-羧基酰胺：用于合成不同取代的多环吲哚结构的多功能合成手柄。

IF 2.9 3区化学

Organic & Biomolecular Chemistry Pub Date : 2025-06-12 DOI: 10.1039/d5ob00761e

Akshay Kamble, Priyanka Deore, Vanshika Agrawal, Adesh Chauhan, Haneesha Gulipelli, Satyasheel Sharma

{"title":"Indole-2-carboxamide: a versatile synthetic handle for the synthesis of diversely substituted polycyclic indole structures.","authors":"Akshay Kamble, Priyanka Deore, Vanshika Agrawal, Adesh Chauhan, Haneesha Gulipelli, Satyasheel Sharma","doi":"10.1039/d5ob00761e","DOIUrl":"https://doi.org/10.1039/d5ob00761e","url":null,"abstract":"Indoles are among the most important N-heterocycles found in natural products, with a wide range of biological and pharmacological properties. The synthesis of naturally occurring complex indole derivatives as well as bioactive synthetic molecules has progressed tremendously. Since many of the bioactive, naturally occurring indole molecules possess polycyclic frameworks, it became essential to develop these scaffolds. In this context, indole derivatives have been utilized as precursors for the synthesis of many important polycyclic indole frameworks. These polycyclic indole molecules also include a fused indole motif. In this regard, there are many fused indole ring systems which can be accessed by indole-2-carboxamide as a key precursor through intramolecular and intermolecular cyclization reactions. This review summarizes the synthetic advancements for the construction of polycyclic fused indole molecules, which have indole-2-carboxamide as a synthetic precursor, and also discusses the synthetic potential and perspective of this essential scaffold. Furthermore, the reaction mechanism of the formation of various fused polycyclic indoles has also been discussed.","PeriodicalId":96,"journal":{"name":"Organic & Biomolecular Chemistry","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144273680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multifunctional supramolecular receptors: aqueous ion recognition, HCl sensing and cytotoxic potential. 多功能超分子受体：水离子识别，HCl感应和细胞毒性电位。

IF 2.9 3区化学

Organic & Biomolecular Chemistry Pub Date : 2025-06-12 DOI: 10.1039/d5ob00585j

Damian Jagleniec, Katarzyna Sęktas, Łukasz Dobrzycki, Miłosz Ludwinek, Anna Nasulewicz-Goldeman, Joanna Wietrzyk, Jan Romański

{"title":"Multifunctional supramolecular receptors: aqueous ion recognition, HCl sensing and cytotoxic potential.","authors":"Damian Jagleniec, Katarzyna Sęktas, Łukasz Dobrzycki, Miłosz Ludwinek, Anna Nasulewicz-Goldeman, Joanna Wietrzyk, Jan Romański","doi":"10.1039/d5ob00585j","DOIUrl":"https://doi.org/10.1039/d5ob00585j","url":null,"abstract":"We describe the design, synthesis, and binding behavior of three supramolecular receptors aimed at selective ion-pair recognition in aqueous and organic media. Incorporating squaramide and tertiary amine functionalities, these receptors exhibit strong affinities for anions and ion pairs, especially in the presence of sodium cations. Notably, protonation of the tertiary amine in receptor 1 significantly enhances its water solubility and anion-binding affinity by increasing the acidity of the squaramide protons, thereby strengthening interactions with chloride anions even in competitive, water-rich environments. Receptor 3, modified with a pyrene unit, functions as a fluorescence sensor capable of extracting chloride from aqueous phases into organic solvents, indicating potential applications in molecular sensing and ion transport. Preliminary biological assays reveal that these compounds exhibit cytotoxic activity comparable to cisplatin on specific cell lines, suggesting promise as therapeutic agents. This study highlights the utility of multifunctional receptors in aqueous ion-pair recognition and transport, with implications for both environmental and biomedical applications.","PeriodicalId":96,"journal":{"name":"Organic & Biomolecular Chemistry","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144273681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biosynthesis of 5-hydroxymethyl-2-furancarboxylic acid from 5-hydroxymethylfurfural via new whole-cell biocatalysts. 新型全细胞生物催化剂催化5-羟甲基糠醛合成5-羟甲基-2-呋喃羧酸。

IF 2.9 3区化学

Organic & Biomolecular Chemistry Pub Date : 2025-06-11 DOI: 10.1039/d5ob00783f

Shi-Kai Jiang, Heng Lei, Ji-Hang Shen, Xi Shen, Xiao-Jun Ji, Zhi-Gang Zhang

{"title":"Biosynthesis of 5-hydroxymethyl-2-furancarboxylic acid from 5-hydroxymethylfurfural via new whole-cell biocatalysts.","authors":"Shi-Kai Jiang, Heng Lei, Ji-Hang Shen, Xi Shen, Xiao-Jun Ji, Zhi-Gang Zhang","doi":"10.1039/d5ob00783f","DOIUrl":"https://doi.org/10.1039/d5ob00783f","url":null,"abstract":"The selective oxidation of biomass-derived 5-hydroxymethylfurfural (HMF) to value-added furan compounds presents significant challenges due to the inherent high reactivity of HMF. In this study, two microorganisms were identified as whole-cell biocatalysts for the synthesis of 5-hydroxymethylfuroic acid (HMFCA) from HMF. The cells of Pseudochrobactrum sp. B2L and Lysinibacillus sp. B2P showed susceptibility to low pH conditions that result from the accumulation of the HMFCA product. Nevertheless, they exhibited high tolerance to the HMF substrate and the 2,5-bis(hydroxymethyl)furan (BHMF) intermediate during the reaction process. Under optimized conditions, a concentration of 200 mM HMF was nearly completely converted into HMFCA, achieving a yield of 99% by utilizing the cells of both microorganisms. Upon increasing the HMF substrate concentration to 300 mM, HMFCA yields of up to 80% were obtained, demonstrating excellent catalytic performance. The identification of Pseudochrobactrum sp. B2L and Lysinibacillus sp. B2P as biocatalysts for the synthesis of HMFCA expands the biocatalytic repertoire available for the sustainable production of bio-based chemicals from HMF. Furthermore, these findings contribute valuable insights for the future identification of related enzymes.","PeriodicalId":96,"journal":{"name":"Organic & Biomolecular Chemistry","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144264851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0