Ni-Catalyzed intramolecular cyclization of Baylis–Hillman adducts of 2-cyanoaniline towards 2,3-dihydroquinolin-4(1H)-ones†

IF 2.7 3区化学 Q1 CHEMISTRY, ORGANIC

Organic & Biomolecular Chemistry Pub Date : 2025-06-26 DOI:10.1039/D5OB00778J

Min Yang, Xuanfeng Li, Tingxi Lai, Jian Xiao, Minghui Xu, Bin Chen, Hai-Liang Ni, Bi-Qin Wang, Ping Hu and Peng Cao

引用次数: 0

Abstract

A Ni-catalyzed reductive cyclization of Baylis–Hillman adducts of 2-cyanoaniline is presented. A novel class of quinolin-4-ones containing a quaternary carbon center were synthesized in moderate to good yields. With ⁱPr-PyBOX as a chiral ligand, the catalytic enantioselective cyclization gave a moderate yield and ee.

Abstract Image

查看原文本刊更多论文

ni催化2-氰苯胺Baylis-Hillman加合物分子内环化2,3-二氢喹啉-4(1H)- 1。

介绍了一种镍催化的2-氰苯胺贝里斯-希尔曼加合物的还原环化反应。以中高收率合成了一类含季碳中心的新型喹啉-4- 1。以iPr-PyBOX为手性配体，催化对映选择性环化得到了中等的产率和ee。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Organic & Biomolecular Chemistry 化学-有机化学

CiteScore

5.50

自引率

9.40%

发文量

1056

审稿时长

1.3 months

期刊介绍： Organic & Biomolecular Chemistry is an international journal using integrated research in chemistry-organic chemistry. Founded in 2003 by the Royal Society of Chemistry, the journal is published in Semimonthly issues and has been indexed by SCIE, a leading international database. The journal focuses on the key research and cutting-edge progress in the field of chemistry-organic chemistry, publishes and reports the research results in this field in a timely manner, and is committed to becoming a window and platform for rapid academic exchanges among peers in this field. The journal's impact factor in 2023 is 2.9, and its CiteScore is 5.5.