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{"title":"Influence of perineal tears and body image disturbance on postpartum sexual quality of life: a cross-sectional study.","authors":"Deborah Fillion, Alessandro Ferdinando Ruffolo, Nathalie Verlet, Carine Martin, Charles Garabedian, Chrystèle Rubod, Yohan Kerbage, Michel Cosson, Louise Ghesquiere, Romain Corroenne, Marine Lallemant","doi":"10.1080/0167482X.2026.2716382","DOIUrl":"https://doi.org/10.1080/0167482X.2026.2716382","url":null,"abstract":"<p><strong>Background: </strong>Whether perineal injury severity independently determines postpartum sexual quality of life (SQoL) is unclear. This study evaluated perineal tears and body image as determinants of SQoL and sexual resumption timing.</p><p><strong>Methods: </strong>A total of 173 women (2-24 months postpartum, vaginal delivery) completed an online questionnaire including the SQoL-F and Body Image Scale (BIS). Women with perineal tear/episiotomy (PT/E; <i>n</i> = 118) were compared with those with an intact perineum (<i>n</i> = 51) using multivariate regression.</p><p><strong>Results: </strong>SQoL-F scores were similar between groups (71.1 ± 23.3 vs 76.9 ± 24.0; <i>p</i> = 0.10), though PT/E delayed sexual resumption (<i>p</i> = 0.04). On multivariate analysis, SQoL-F was independently associated with dyspareunia (β = -10.96; <i>p</i> < 0.001), body image disturbance (β = -0.93; <i>p</i> < 0.001), and pre-pregnancy sexual satisfaction (β = +4.99; <i>p</i> = 0.001), but not tear type. Delayed resumption was independently associated with OASI (OR = 7.02; <i>p</i> = 0.02), first/second-degree tears (OR = 2.20; <i>p</i> = 0.04), and lower pre-pregnancy relationship satisfaction (OR = 0.50; <i>p</i> = 0.048).</p><p><strong>Conclusions: </strong>Postpartum SQoL is primarily determined by dyspareunia and body image disturbance rather than perineal tear severity. OASI carries a substantial risk of delayed sexual resumption, warranting dedicated postpartum counseling.</p>","PeriodicalId":50072,"journal":{"name":"Journal of Psychosomatic Obstetrics & Gynecology","volume":"48 1","pages":"2716382"},"PeriodicalIF":2.6,"publicationDate":"2027-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149149194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Visual behaviour in acute stress during simulated and on-road driving.","authors":"Anastasiia Bakhchina, Karina Arutyunova, Evgenii Burashnikov, Nikita Timakin, Andrei Filimonov, Ivan Shishalov","doi":"10.1080/10253890.2026.2739892","DOIUrl":"https://doi.org/10.1080/10253890.2026.2739892","url":null,"abstract":"<p><p>Driving frequently exposes individuals to conditions triggering acute stress, but its effects on drivers' visual behaviour remain insufficiently understood. We used the heart rate dynamics to label acute stress episodes in recordings from 881 participants who performed simulated and on-road driving. Considering acute stress as a phased process, we analysed eye gaze metrics during stress activation and stress resistance periods. In simulation, stress activation was accompanied by more frequent and shorter fixations, greater fixation area, higher stationary gaze entropy, and lower gaze transition entropy. In on-road driving, significant effects were more selective, with the most consistent changes observed for the horizontal diameter of fixation area and entropy-based gaze measures. During stress resistance, many measures partially returned toward non-stress levels, suggesting a transition from initial reactivity toward stabilisation. These findings support gaze-derived measures as candidate indicators of changes in visual behaviour related to acute stress during driving, while highlighting the importance of considering acute stress as a phased process. They also indicate that multimodal context-aware validation is needed for translation into real-time driver state monitoring and safety-relevant assistance applications.</p>","PeriodicalId":51173,"journal":{"name":"Stress-The International Journal on the Biology of Stress","volume":"30 1","pages":"2739892"},"PeriodicalIF":3.7,"publicationDate":"2027-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149240233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enterovirus 2B protein: From viroporin to membrane stress sensor, mechanistic principles of multi-pathway regulation.","authors":"Zengjun Ji, Yikun Chen, Hongxing Shen","doi":"10.1080/21505594.2026.2739074","DOIUrl":"10.1080/21505594.2026.2739074","url":null,"abstract":"<p><p>Enterovirus 2B is a highly conserved, functionally versatile, nonstructural protein. The classic viroporin model, which restricts its role to ion channel formation, cannot account for its interactions with host factors such as Bcl-2-associated X protein, interleukin enhancer-binding factor 2, and karyopherin subunit alpha 1, nor its functional divergence among enteroviruses. We propose a novel, testable membrane stress sensor hypothesis: the transmembrane helices of 2B sense lipid composition and pH changes, and through conformational dynamics, spatiotemporally coordinate calcium signaling, cell death pathway selection, including apoptosis, pyroptosis, autophagy, and ferroptosis, and immune evasion. We elaborate on this framework across six dimensions: structure-function mapping, calcium signaling, cell death pathways, immune evasion, evolutionary footprint, and antiviral targeting, along with cross-virus comparisons. We highlight key evidence gaps and limitations, and propose several future research directions. This framework establishes a mechanistic foundation for understanding 2B function and guiding rational anti-enteroviral drug designs.</p>","PeriodicalId":23747,"journal":{"name":"Virulence","volume":"18 1","pages":"2739074"},"PeriodicalIF":6.8,"publicationDate":"2027-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13652057/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149115522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Salivary oxytocin and testosterone in empathic stress responding: a pilot study.","authors":"Katja Heilmann, Martin Walter, Veronika Engert","doi":"10.1080/10253890.2026.2720481","DOIUrl":"https://doi.org/10.1080/10253890.2026.2720481","url":null,"abstract":"<p><p>Suffering the stress of others (termed empathic stress or stress contagion) may affect an individual's health and well-being. To understand the underlying hormonal processes of empathic stress, <i>N</i> = 108 opposite-sex dyads were tested, with one dyad partner passively observing the other undergoing a standardized psychosocial laboratory stressor. A positive link between oxytocin release and empathic stress response was hypothesized, while a negative relationship was expected for testosterone release. Associations of observer oxytocin and testosterone levels with two components of empathic stress were examined: stress resonance (i.e. synchronized observer-target responses) and vicarious stress (observer responses independent of target stress). During the passive observation of a stressed target, salivary oxytocin and testosterone levels increased by 16.64% and 23.00%, respectively, followed by a drop back to baseline levels. Supporting our hypotheses, increased observer oxytocin reactivity was linked to greater stress resonance in HF-HRV reactivity. This association was reversed in low oxytocin responders. Further, testosterone reactivity was negatively associated with stress resonance in heart rate activity. However, testosterone also showed a positive association with vicarious cortisol activity, which resembles the response pattern seen in first-hand stress exposure. We conclude that stress resonance may be the more empathy-dependent component of the empathic stress construct, aligning with previous work on the involvement of oxytocin and testosterone in empathy. To draw further conclusions about the role of oxytocin and testosterone in empathic stress response, future studies including a control group and hormone stimulation are needed.</p>","PeriodicalId":51173,"journal":{"name":"Stress-The International Journal on the Biology of Stress","volume":"30 1","pages":"2720481"},"PeriodicalIF":3.7,"publicationDate":"2027-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149149686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trait-like proteomic signatures of stress resilience: correlates of freeze-like response resistance.","authors":"Jan Kučera, Markéta Makarová, Michal Vít, Jan Novák, Filip Zlámal, Lucie Ráčková, Jana Fialová Kučerová, Markéta Grulichová, Tomáš Vojtíšek, Radek Šíp, Alžběta Fiedlerová, Julie Bienertová-Vašků","doi":"10.1080/10253890.2026.2733738","DOIUrl":"https://doi.org/10.1080/10253890.2026.2733738","url":null,"abstract":"<p><p>The freeze-like response is a fundamental defensive mechanism that remains poorly understood despite its potential to impair functioning under acute threat. We examined its biological correlates using untargeted serum proteomics in participants exposed to ecologically valid simulated armed attacks, comparing untrained individuals (<i>n</i> = 20) with experienced police rapid response personnel (<i>n</i> = 20). Freeze-like responses, characterized by unresponsiveness to attack, were assessed via expert video analysis of participant performance during the scenarios. Serum samples collected before and after threat exposure were analyzed via LC‒MS/MS, identifying 1,238 protein groups. Experienced personnel demonstrated markedly greater resistance to freeze-like responses. No significant proteomic changes were observed from pre- to post-exposure in either group, suggesting that freeze-resistance may be associated with stable, trait-like signatures rather than acute stress-responsive processes. Weighted gene co-expression network analysis identified a module strongly correlated with freeze-resistance (<i>r</i> = 0.75, <i>p</i> = 4 × 10^-9) and training status (<i>r</i> = 0.71, <i>p</i> = 6 × 10^-8), which also correlated with skeletal muscle mass (<i>r</i> = 0.57, <i>p</i> = 8 × 10^-5). This module was enriched for processes including extracellular matrix organization, muscle development, carbohydrate metabolism, and antioxidant activity. These molecular patterns may reflect the downstream effects of comprehensive training that integrates physical conditioning, operational experience, and psychological preparation. This study provides the first proteomic characterization of freeze-like response resistance under realistic threat conditions, supporting the view that resilience involves stable physiological adaptations rather than solely reactive stress mechanisms.</p>","PeriodicalId":51173,"journal":{"name":"Stress-The International Journal on the Biology of Stress","volume":"30 1","pages":"2733738"},"PeriodicalIF":3.7,"publicationDate":"2027-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149217265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"\"Sailing Two Boats\" the fragmented identity of working women and the hidden labor of infertility: a qualitative analysis.","authors":"Swati Dhar, Vidyashree Ganesh Poojari, Prashanth Adiga, Anjali Mundkur, Akash Tomar, Pratap Kumar","doi":"10.1080/0167482X.2026.2742884","DOIUrl":"https://doi.org/10.1080/0167482X.2026.2742884","url":null,"abstract":"<p><strong>Objective: </strong>To explore how professional women undergoing assisted reproductive technology (ART) experience and manage conflicts between treatment demands and professional identity; and to identify ways healthcare professionals can support them.</p><p><strong>Methods: </strong>Following COREQ guidelines, semi-structured, in-depth interviews were conducted with 18 professional women undergoing ART in a tertiary care hospital. Reflexive Thematic Analysis bolstered by interdisciplinary investigator triangulation (clinical and basic science) ensured thematic confirmability.</p><p><strong>Results: </strong>Analysis revealed <i>Gendered Occupational Asymmetry</i> (female occupational burden regardless of clinical aetiology), the <i>Insider Paradox</i> (the role reversal for healthcare professionals) and the <i>Workplace Panopticon</i> (constant self-surveillance to preserve professional authority). Interestingly, work simultaneously often acted as a <i>Sanctuary of Competence</i>, providing psychological respite. Finally, narratives exposed an <i>Existential Rumination</i> (mourning past personal-professional decisions) and permanent temporal career stalling. These themes were further mapped onto a 'A Day in the Life' structural framework to illustrate compounding daily burdens.</p><p><strong>Conclusions: </strong>Current clinical lifestyle directives inadequately account for the rigid psycho-socioeconomic structures governing professional women. Based on identified themes, we propose targeted measures for healthcare professionals to deliver patient-centric care by integrating occupational awareness and identity-sensitive counselling into routine ART practice, thereby potentially reducing distress and improving treatment experience.</p>","PeriodicalId":50072,"journal":{"name":"Journal of Psychosomatic Obstetrics & Gynecology","volume":"48 1","pages":"2742884"},"PeriodicalIF":2.6,"publicationDate":"2027-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149129006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting IGD treatment outcomes across interventions using a whole-brain functional connectome biomarker.","authors":"Meiting Wei, Xin Luo, Jiejie Fu, Shuang Li, Haosen Ni, Jiang Liu, Guang-Heng Dong","doi":"10.1080/19585969.2026.2742156","DOIUrl":"10.1080/19585969.2026.2742156","url":null,"abstract":"<p><strong>Background: </strong>Although treatment approaches have been explored in internet gaming disorder (IGD), however, little is known about the specific neural activity that is associated with treatment outcomes. This study aims to establish a treatment-sensitive network that reliably predicts treatment outcomes across different interventions for IGD.</p><p><strong>Methods: </strong>Resting-state fMRI data were collected from 90 individuals with IGD who received one of three different intervention protocols (mindfulness meditation, approach bias modification, or retrieval-aversive conditioning training). Connectome-based predictive modelling (CPM) was used to build a treatment-sensitive network to predict individual symptom reduction, then validated them on the external dataset.</p><p><strong>Results: </strong>The negative (<i>r</i> = 0.401, <i>p</i> <.001) and combined network (<i>r</i> = 0.480, <i>p</i> <.001) can significantly predict a reduction of addiction severity (baseline minus post-test). Specifically, the negative network was primarily centred on the motor, subcortical, and salience networks. The positive network primarily involved cerebellar-related connections. Incorporating these into a combined model significantly improved predictive accuracy, suggesting that cerebellar-related connectivity may contribute to the prediction of intervention-related clinical improvement. Finally, the treatment-sensitive network was validated in a separate data.</p><p><strong>Conclusions: </strong>This study established a treatment-sensitive network based on the whole-brain connectome. These findings provide valuable empirical evidence for identifying biomarkers for IGD treatment and advance personalised therapeutic strategies.</p><p><strong>Clinical trials registration: </strong>The trial protocol was pre-registered with the Chinese Clinical Trial Registry (www.chictr.org.cn; ChiCTR2300077831(MM), ChiCTR2300075869(ApBm), ChiCTR2500095444(R-AC), ChiCTR2400090834(SAE)).</p>","PeriodicalId":54343,"journal":{"name":"Dialogues in Clinical Neuroscience","volume":"29 1","pages":"1-14"},"PeriodicalIF":5.1,"publicationDate":"2027-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13660549/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149171337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From prevalence to prognosis: the clinical relevance of depression and anxiety in COPD.","authors":"Josep Montserrat-Capdevila","doi":"10.1080/02813432.2026.2738628","DOIUrl":"10.1080/02813432.2026.2738628","url":null,"abstract":"","PeriodicalId":21521,"journal":{"name":"Scandinavian Journal of Primary Health Care","volume":"45 1","pages":"2738628"},"PeriodicalIF":1.9,"publicationDate":"2027-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13665694/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149184326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative efficacy of topical garlic extract and 20% podophyllin solution in the treatment of female genital warts: a triple-blind randomized clinical trial.","authors":"Mohsen Naseri, Zahra Sarfallah, Mina Saadat, Fatemeh Masaebi, Maryam Damghanian","doi":"10.1080/09546634.2026.2746272","DOIUrl":"10.1080/09546634.2026.2746272","url":null,"abstract":"<p><strong>Background: </strong>Genital warts caused by human papillomavirus are common sexually transmitted infections, with no single therapy providing consistent clearance. Garlic extract has antiviral and antiproliferative properties and may offer a low-cost treatment.</p><p><strong>Objective: </strong>To compare the efficacy and safety of topical 5% garlic extract with 20% podophyllin solution in women with genital warts.</p><p><strong>Methods: </strong>Seventy-four women were randomized to 5% garlic extract (<i>n</i> = 37) or 20% podophyllin (<i>n</i> = 37), applied weekly for four weeks. Wart size and count were assessed using marginal models (generalized estimating equations). The primary outcome was change in mean wart size and the secondary outcome was change in wart count.</p><p><strong>Results: </strong>Mean wart size decreased from 1.61 ± 0.81 to 0.60 ± 0.82 mm with garlic extract and from 2.96 ± 7.99 to 0.62 ± 0.73 mm with podophyllin. The between-group <i>p</i>-value at final assessment was 0.756; group × time interaction <i>p</i> values were 0.329 for wart size and 0.583 for count. Among 35 and 37 participants analyzed, complete response occurred in 18 (51.4%) and 19 (51.4%), respectively; complete or partial response occurred in 23 (65.7%) and 25 (67.6%). Itching and burning occurred in 8 (21.6%) garlic-treated participants each.</p><p><strong>Conclusion: </strong>Both treatments reduced wart size and count, with similar response rates. Four-week follow-up precluded assessment of durability and recurrence.</p>","PeriodicalId":94235,"journal":{"name":"The Journal of dermatological treatment","volume":"38 1","pages":"2746272"},"PeriodicalIF":3.9,"publicationDate":"2027-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149170862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nine minutes is enough: An accelerated fMRI protocol for reliable connectivity mapping in healthy young adults.","authors":"Adrian Falkowski, Krzysztof Szwed","doi":"10.1080/19585969.2026.2710912","DOIUrl":"10.1080/19585969.2026.2710912","url":null,"abstract":"<p><strong>Introduction: </strong>Resting‑state fMRI is widely used to map brain connectivity, yet the field lacks a clear, data‑driven standard for acquisition duration. We compared traditional Single‑Band (SB) imaging with an accelerated Multiband factor 4 (MB4) protocol to identify a time‑efficient approach for capturing stable network topology.</p><p><strong>Methods: </strong>Twenty‑five healthy young adults completed two sessions one month apart, each including counterbalanced 13‑minute SB and MB4 scans. Test-retest reliability was evaluated across multiple durations using Portrait Divergence, a multiscale graph‑theoretic metric. Supplementary analyses compared Portrait Divergence with the field-standard Intraclass Correlation Coefficient, assessed robustness across preprocessing pipelines and parcellation schemes, and examined MB4's ability to capture both cortical and subcortical connectivity.</p><p><strong>Results: </strong>MB4 consistently outperformed SB across all tested durations, with peak topological stability at 9 minutes. Stability declined beyond this point, likely due to cumulative motion artefacts. Supplementary analyses confirmed MB4's robustness across preprocessing strategies and atlas choices and demonstrated effective whole‑brain coverage.</p><p><strong>Conclusions: </strong>In healthy young adults, MB4 captures network topology more effectively than SB and reaches peak stability at 9 minutes before declining, challenging the assumption that longer scans are always better. These findings require validation in clinical, paediatric, and geriatric cohorts.</p>","PeriodicalId":54343,"journal":{"name":"Dialogues in Clinical Neuroscience","volume":"29 1","pages":"24-31"},"PeriodicalIF":5.1,"publicationDate":"2027-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13670261/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149186202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}