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{"title":"Lived experience and global health architecture reform: from afterthought to cornerstone.","authors":"Johanna Ralston,Lavanya Vijayasingham,Chikhulupiliro Stanley Ng'ombe,Lucia Feito Allonca,Prisca Githuka,Nupur Lalvani,Ratna Devi","doi":"10.1016/j.langlo.2026.103999","DOIUrl":"https://doi.org/10.1016/j.langlo.2026.103999","url":null,"abstract":"","PeriodicalId":48783,"journal":{"name":"Lancet Global Health","volume":"22 1","pages":"103999"},"PeriodicalIF":34.3,"publicationDate":"2027-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148400840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sustaining progress in HIV care in Africa with a transition to enabled self-care: a modelling study.","authors":"Andrew N Phillips,Kenly Sikwese,Valentina Cambiano,Loveleen Bansi-Matharu,Jennifer Smith,Euphemia Sibanda,Cheryl Johnson,Brooke E Nichols,Edinah Mudimu,Frances M Cowan,Paul Revill","doi":"10.1016/s2214-109x(26)00088-4","DOIUrl":"https://doi.org/10.1016/s2214-109x(26)00088-4","url":null,"abstract":"BACKGROUNDThe funding crisis for HIV services in east, central, southern, and west Africa means that innovative strategies for continuing prevention and care for HIV are needed. One such strategy is enabled self-care: the provision of free HIV self-tests, pre-exposure prophylaxis (PrEP), tenofovir-lamivudine-dolutegravir for post-exposure prophylaxis (PEP), and antiretroviral therapy (ART) provided in local pharmacies and by community-based health workers. We modelled the introduction of a policy of transition to enabled self-care compared with continuation of current service provision.METHODSWe used an established individual-based model (HIV Synthesis) to simulate HIV epidemics in 1000 setting scenarios representing diversity in setting characteristics across east, central, southern, and west Africa, and uncertainty in parameter values. For each setting scenario, we simulated 100 000 people aged ≥15 years between 1989 and 2076. The model incorporates ART access informed by studies of barriers to accessing clinics. Our main outcomes included the number of adults testing for HIV in a 3-month period, PrEP and PEP use, coverage of people on ART, HIV-related deaths, HIV incidence, perinatal transmission, disability-adjusted life-years (DALYs), and costs. We chose a 50-year time horizon to capture the full effects of the policies. For each setting scenario, we performed three replicate runs for each of the two policies and for each policy took the mean across the three runs.FINDINGSOur model estimated that transitioning to enabled self-care would lead to increases in testing from a median of 5·0% (90% range 2·3-11·5) of adults testing per 3 months to 12·7% (6·6-21·1), an increase in PrEP and PEP use (+0·5% of adults [0·0-2·2]), and an increase in ART coverage for people with diagnosed HIV (+1% [0-3]) with enhanced benefits in those previously without access to PrEP and testing services. Enabled self-care was predicted to result in a median 18% (90% range 4-33) fewer HIV deaths, and a relative rate of 0·73 (0·52-0·94) in terms of HIV incidence per 100 person-years over 10 years. Overall, over a 50-year time horizon, enabled self-care was predicted to cut discounted programme costs by US$6·0 million (5·6-6·5; a 7% decrease), avert 34 000 (32 200 to 36 000) DALYS, and be cost-effective (at a cost-effectiveness threshold of $300 per DALY averted) in 95% of setting scenarios. The mean undiscounted annual cost per adult in the population per year across setting scenarios was $12 (median $11 [90% range 6-22]). The higher the HIV prevalence was in a setting scenario, the more cost-effective the policy was found to be (odds ratio 1·41 [95% CI 1·25-1·60] per 1% higher HIV prevalence).INTERPRETATIONIntroduction of community access to self-tests and antiretroviral drugs through a transition to enabled self-care is very likely to be cost-effective in most settings in east, central, southern, and west Africa; enable incidence declines to be sustained at reduced cos","PeriodicalId":48783,"journal":{"name":"Lancet Global Health","volume":"40 1","pages":"103943"},"PeriodicalIF":34.3,"publicationDate":"2027-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148349219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enabled self-care for HIV infection: an inflection point for sustainable epidemic control.","authors":"Dvora Joseph Davey","doi":"10.1016/j.langlo.2026.103970","DOIUrl":"https://doi.org/10.1016/j.langlo.2026.103970","url":null,"abstract":"","PeriodicalId":48783,"journal":{"name":"Lancet Global Health","volume":"1 1","pages":"103970"},"PeriodicalIF":34.3,"publicationDate":"2027-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148349222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EXPECTATION-MAXIMIZATION FOR STRUCTURE DETERMINATION DIRECTLY FROM CRYO-EM MICROGRAPHS.","authors":"Shay Kreymer, Amit Singer, Tamir Bendory","doi":"10.3934/ipi.2026033","DOIUrl":"10.3934/ipi.2026033","url":null,"abstract":"<p><p>A single-particle cryo-electron microscopy (cryo-EM) measurement, called a micrograph, consists of multiple two-dimensional tomographic projections of a three-dimensional (3-D) molecular structure at unknown locations, taken under unknown viewing directions. All existing cryo-EM algorithmic pipelines first locate and extract the projection images, and then reconstruct the structure from the extracted images. However, if the molecular structure is small, the signal-to-noise ratio (SNR) of the data is very low, making it challenging to accurately detect projection images within the micrograph. Consequently, all standard techniques fail in low-SNR regimes. To recover molecular structures from measurements of low SNR, and in particular small molecular structures, we devise an approximate expectation-maximization algorithm to estimate the 3-D structure directly from the micrograph, bypassing the need to locate the projection images. We corroborate our computational scheme with numerical experiments and present successful structure recoveries from simulated noisy measurements.</p>","PeriodicalId":50274,"journal":{"name":"Inverse Problems and Imaging","volume":"27 ","pages":"110-133"},"PeriodicalIF":1.6,"publicationDate":"2027-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13384443/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148609636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"Combining network pharmacology and transcriptomics to validate and explore the efficacy and mechanism of Huayu Wan in treating non-small cell lung cancer\" [J. Ethnopharmacol. 347 (2025) 119724].","authors":"Tangke Gao, Shaopu Hu, Min Jiang, Guangyin Ou, Ruikang Zhong, Jingyi Sun, Qian Yang, Kaiwen Hu, Lei Gao","doi":"10.1016/j.jep.2026.122011","DOIUrl":"10.1016/j.jep.2026.122011","url":null,"abstract":"","PeriodicalId":15761,"journal":{"name":"Journal of ethnopharmacology","volume":" ","pages":"122011"},"PeriodicalIF":6.8,"publicationDate":"2027-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148239290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"Xiao-Liu Tang (XLT), a traditional Chinese medicine formula that suppresses the progression of cervical cancer by inducing apoptosis and inhibiting cell migration\" [J Ethnopharmacol. (2026) 358 120966].","authors":"Shanxing Dang, Xiaoxuan Tang, Qingyun Li, June Wu, Yue Hu, Xiqing Liu, Danong Cao, Chuwen Feng, Yehong Sun, Jianmei Huang, Wencong Song, Xuelian Du","doi":"10.1016/j.jep.2026.122028","DOIUrl":"10.1016/j.jep.2026.122028","url":null,"abstract":"","PeriodicalId":15761,"journal":{"name":"Journal of ethnopharmacology","volume":" ","pages":"122028"},"PeriodicalIF":6.8,"publicationDate":"2027-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148317370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"Morus alba L.-Glycyrrhiza uralensis alleviate chronic obstructive pulmonary disease by inhibiting the arachidonic acid metabolism pathway\" [J. Ethnopharmacol. 349 (2025) 119904].","authors":"Hong Du, Shangcheng Xu, Hong Ke, Qian Yang, Wei Xiong, Mengai Liu, Meijuan Shao, Yanru Cui, Fei Qu","doi":"10.1016/j.jep.2026.122029","DOIUrl":"10.1016/j.jep.2026.122029","url":null,"abstract":"","PeriodicalId":15761,"journal":{"name":"Journal of ethnopharmacology","volume":" ","pages":"122029"},"PeriodicalIF":6.8,"publicationDate":"2027-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148258295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"Oleanolic acid 28-O-β-D-glucopyranoside alleviates TNBS-induced ulcerative colitis in rat by regulating Nrf2/x-CT/GPX4-mediated ferroptosis\" [Journal of Ethnopharmacology 353 (2025) 120369].","authors":"Caixia Wang, Zhuoqiao Li, Linxuan Liu, Wang Jia, Xiaoyu Geng, Hanlin Liu, Cuizhu Wang, Yuanyuan Wu, Hongqiang Lin, Jinping Liu","doi":"10.1016/j.jep.2026.122016","DOIUrl":"10.1016/j.jep.2026.122016","url":null,"abstract":"","PeriodicalId":15761,"journal":{"name":"Journal of ethnopharmacology","volume":" ","pages":"122016"},"PeriodicalIF":6.8,"publicationDate":"2027-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148264764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"1-Deoxynojirimycin attenuates diabetic cardiomyopathy via PI3K/AKT-mediated mitochondrial protection and anti-apoptosis.","authors":"Yiwei Chen, Huixin Yang, Xue Li, Xianjie Hou, Han Xu, Jinxiang Han, Meina Yang","doi":"10.1016/j.jep.2026.122254","DOIUrl":"10.1016/j.jep.2026.122254","url":null,"abstract":"<p><strong>Ethnopharmacological relevance: </strong>1-Deoxynojirimycin (DNJ), a naturally occurring alkaloid derived from mulberry leaves (Morus alba L.), is a powerful α-glucosidase inhibitor that has notable hypoglycemic effects. Nonetheless, the fundamental molecular mechanisms-especially diabetic cardiomyopathy (DCM)-are still not fully understood.</p><p><strong>Purpose: </strong>This study sought to determine the cardioprotective effect of DNJ in diabetic cardiomyopathy and to elucidate the associated molecular mechanism.</p><p><strong>Methods: </strong>A high glucose-induced DCM model was established in H9C2 cells and db/db mice. DNJ was administered by gavage or coculture with cells. The molecular mechanism of DNJ activity and changes in the activity of the PI3K/AKT pathway were evaluated by echocardiography, tissue staining, transmission electron microscopy, fluorescence probes, biochemical kits, Western blotting, and transcriptome sequencing, and the pathway was verified by the use of inhibitors.</p><p><strong>Results: </strong>In vivo tests initially demonstrated that DNJ may lower body weight and fasting blood glucose levels; enhance glucose tolerance and cardiac performance; diminish myocardial fibrosis, myocardial hypertrophy, and lipid accumulation; and reduce myocardial cell death in db/db mice. DNJ therapy improved the HG-induced reduction in H9C2 cell viability, reduced ROS levels, mitigated oxidative damage, and inhibited cell death. DNJ can restore HG-mediated suppression of ATP5B expression and ATP levels, potentially enhancing mitochondrial energy utilization. The therapeutic efficacy of DNJ may be contingent upon the PI3K/AKT pathway, underscoring its regulatory significance, particularly in mediating cellular responses to oxidative stress and promoting cell survival in H9C2 cells.</p><p><strong>Conclusions: </strong>Our preliminary findings suggest that DNJ may alleviate diabetic myocardial injury, possibly by triggering the PI3K/AKT pathway. This work offers a preliminary rationale for DNJ as a prospective treatment agent for DCM.</p>","PeriodicalId":15761,"journal":{"name":"Journal of ethnopharmacology","volume":" ","pages":"122254"},"PeriodicalIF":6.8,"publicationDate":"2027-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148620302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"Integrated metabolomics and network pharmacology study on Si-miao-yong-an Decoction in regulating sphingolipid metabolism and improving vascular injury on thromboangiitis obliterans\" [J. Ethnopharmacol. 357 (2026) 120868].","authors":"Xingjing Yang, Xianshu Song, Fangyu Zhu, Xingyu Yu, Jiamin Cao, Jie Chen, Zhongxiang Zhao","doi":"10.1016/j.jep.2026.122002","DOIUrl":"10.1016/j.jep.2026.122002","url":null,"abstract":"","PeriodicalId":15761,"journal":{"name":"Journal of ethnopharmacology","volume":" ","pages":"122002"},"PeriodicalIF":6.8,"publicationDate":"2027-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148258283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}