IF 8.1 2区医学

Drug Delivery Pub Date : 2026-12-31 Epub Date: 2025-12-19 DOI: 10.1080/10717544.2025.2576199

Xianyan Chen, Yuanfeng Wei, Xiaorong Chen, Lingnan Zheng, Yaqin Zhao, Jia You, Cheng Yi, Xi Yang

{"title":"Hydrogel-Based intraperitoneal drug delivery platforms for peritoneal metastasis: strategies, advances, and prospects.","authors":"Xianyan Chen, Yuanfeng Wei, Xiaorong Chen, Lingnan Zheng, Yaqin Zhao, Jia You, Cheng Yi, Xi Yang","doi":"10.1080/10717544.2025.2576199","DOIUrl":"https://doi.org/10.1080/10717544.2025.2576199","url":null,"abstract":"Peritoneal metastasis (PM), as a terminal stage of malignant tumors with extremely poor prognosis, remains a clinical challenge. Intraperitoneal (IP) administration enhances local drug concentrations, improving survival outcomes for PM patients. However, rapid drug clearance and uneven distribution limit its therapeutic potential. In recent years, hydrogel-based drug delivery systems have garnered attention due to their excellent biocompatibility, drug loading capacity, and controlled release properties. The use of hydrogel-loaded drugs via IP injection can significantly improve anti-cancer efficacy by increasing the local drug concentration, prolonging the retention time of the drug in the peritoneal cavity, and decreasing systemic toxicity. This review summarizes the pathogenesis and current treatment strategies of PM, emphasizing various drugs (including chemotherapy agents, immunotherapeutics, targeted drugs, radioactive isotopes, and herbal medicines) delivered via hydrogel-based IP administration. Furthermore, it highlights the potential of nanoparticles and microparticle-hydrogel composites to further improve drug delivery, offering new strategies for PM treatment and theoretical basis for clinical rational drug use.","PeriodicalId":11679,"journal":{"name":"Drug Delivery","volume":"33 1","pages":"2576199"},"PeriodicalIF":8.1,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145780493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Statement of retraction: insulin-loaded PLGA microspheres for glucose-responsive release. 缩回声明：胰岛素负载PLGA微球用于葡萄糖反应释放。

IF 8.1 2区医学

Drug Delivery Pub Date : 2026-12-31 Epub Date: 2025-12-19 DOI: 10.1080/10717544.2025.2604934

引用次数: 0

Tumor microenvironment-responsive conformational activation of apoA-I mimetic peptides for targeted cancer therapy. 肿瘤微环境响应构象激活的apoA-I模拟肽靶向癌症治疗。

IF 8.1 2区医学

Drug Delivery Pub Date : 2026-12-31 Epub Date: 2025-12-17 DOI: 10.1080/10717544.2025.2604086

Mengjie Rui, Lei Fang, Mengfei Jia, Wenyan Liang, Yinfeng Li, Yaoshun Ruan, Chunlai Feng

{"title":"Tumor microenvironment-responsive conformational activation of apoA-I mimetic peptides for targeted cancer therapy.","authors":"Mengjie Rui, Lei Fang, Mengfei Jia, Wenyan Liang, Yinfeng Li, Yaoshun Ruan, Chunlai Feng","doi":"10.1080/10717544.2025.2604086","DOIUrl":"https://doi.org/10.1080/10717544.2025.2604086","url":null,"abstract":"Apolipoprotein A-I (ApoA-I) mimetic peptides have garnered attention as potential anticancer agents owing to their role in cholesterol metabolism and ability to interact with the SR-BI receptor. However, their tendency to form lipid-bound structures in circulation limits their tumor-targeting therapeutic potential and raises the risk of off-target effects. In this study, we engineered a stimuli-responsive ApoA-I mimetic peptide by incorporating reactive oxygen species (ROS) -responsive amino acid derivatives into its sequence. Under normal physiological conditions, the peptide adopted a disordered conformation, minimizing nonspecific interactions. In contrast, the exposure to the tumor microenvironment, which is characterized by low pH and elevated ROS, could trigger a conformational transition to a structured α-helical state, thereby enhancing its membrane-disruptive and tumor-targeting capabilities. Molecular dynamics simulations predicted a rapid increase in α-helical content for the peptide candidate 5A under tumor-like conditions. These predictions were experimentally validated using circular dichroism spectroscopy, liposome leakage assays, and transmission electron microscopy, which demonstrated that peptide 5A effectively interacted with lipid membranes only upon activation in a tumor-like environment. In vitro cytotoxicity assays further confirmed the selective anticancer activity of peptide 5A under acidic conditions, while in vivo imaging and tumor inhibition studies in breast cancer models revealed significant tumor accumulation and a tumor growth inhibition rate of up to 71.43% at a 6 mg/kg dose. Our results demonstrated the potential of stimuli-responsive ApoA-I mimetic peptides for targeted cancer therapy, offering a promising strategy to enhance therapeutic efficacy while minimizing systemic toxicity.","PeriodicalId":11679,"journal":{"name":"Drug Delivery","volume":"33 1","pages":"2604086"},"PeriodicalIF":8.1,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145767549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of uterine peristalsis in artificial hormone treatment versus aromatase inhibitor-stimulated frozen embryo transfer cycles. 人工激素治疗与芳香酶抑制剂刺激的冷冻胚胎移植周期子宫蠕动的比较。

IF 1.7 4区医学

Gynecological Endocrinology Pub Date : 2026-12-31 Epub Date: 2025-12-16 DOI: 10.1080/09513590.2025.2602969

Erhan Şimşek, Gülşen Doğan Durdağ, Didem Alkaş Yağınç, Selçuk Yetkinel, Pınar Çağlar Aytaç

{"title":"Comparison of uterine peristalsis in artificial hormone treatment versus aromatase inhibitor-stimulated frozen embryo transfer cycles.","authors":"Erhan Şimşek, Gülşen Doğan Durdağ, Didem Alkaş Yağınç, Selçuk Yetkinel, Pınar Çağlar Aytaç","doi":"10.1080/09513590.2025.2602969","DOIUrl":"https://doi.org/10.1080/09513590.2025.2602969","url":null,"abstract":"Objective: Uterine peristalsis, which originates from sub-endometrial zone of myometrium, is observed at ultrasonography as a wave-like activity of endometrium. Increased uterine peristalsis is suggested to be related to decreased pregnancy rates in both fresh and frozen embryo transfer cycles. The aim of this study is to compare the effects of two different frozen embryo transfer preparation protocols on the frequency of uterine peristalsis and to evaluate the effect of peristalsis on pregnancy rates.Methods: In this observational cohort study, 3-min transvaginal ultrasound videos were recorded one hour before embryo transfer in frozen embryo transfer cycles prepared by either artificial hormone treatment or aromatase inhibitor stimulation. Peristalsis frequency was assessed by reviewing videos at triple speed. Consequent pregnancy outcomes were also analyzed.Results: During the study period of four months, a total of 147 patients with 99 artificial hormone treatments and 48 aromatase inhibitor-stimulated frozen embryo transfer cycles were included. The absence of uterine peristalsis was observed in 27.1% of the aromatase inhibitor-stimulated patients and 23.2% of the artificial hormone-treated patients (p = 0.68). Among those with peristalsis, the frequency was similar between groups (0.95 ± 0.59 and 0.98 ± 0.68 for the aromatase inhibitor-stimulated and artificial hormone treatment protocols, respectively; p = 0.97). Peristalsis presence or frequency was not associated with pregnancy or live birth rates.Conclusions: In this study, uterine peristalsis frequency at frozen embryo transfer cycles did not differ between endometrial preparation protocols and showed no significant association with pregnancy outcomes. Further randomized studies are warranted.","PeriodicalId":12865,"journal":{"name":"Gynecological Endocrinology","volume":"42 1","pages":"2602969"},"PeriodicalIF":1.7,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145762644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ambulatory blood pressure variability in prediction of target organ injury: the SHIP AHOY study. 动态血压变异性预测靶器官损伤：SHIP AHOY研究。

IF 2.6 3区医学

Pediatric Nephrology Pub Date : 2026-12-01 Epub Date: 2025-05-19 DOI: 10.1007/s00467-025-06803-4

Coral D Hanevold, Jang Dong Seo, Stephen R Daniels, Bonita E Falkner, Michael A Ferguson, Joseph T Flynn, Julie R Ingelfinger, Philip R Khoury, Marc B Lande, Kevin E Meyers, Mark Mitsnefes, Joshua Samuels, Elaine M Urbina

{"title":"Ambulatory blood pressure variability in prediction of target organ injury: the SHIP AHOY study.","authors":"Coral D Hanevold, Jang Dong Seo, Stephen R Daniels, Bonita E Falkner, Michael A Ferguson, Joseph T Flynn, Julie R Ingelfinger, Philip R Khoury, Marc B Lande, Kevin E Meyers, Mark Mitsnefes, Joshua Samuels, Elaine M Urbina","doi":"10.1007/s00467-025-06803-4","DOIUrl":"10.1007/s00467-025-06803-4","url":null,"abstract":"Background: Ambulatory hypertension is associated with elevated left ventricular mass index (LVMI), cardiac dysfunction, and increased arterial stiffness in adolescents. Whether the addition of measures of BP variability improves the prediction of subclinical cardiovascular target organ damage (TOD) over mean BP measures is not known.Methods: We assessed clinic and ambulatory BP (ABP), anthropometrics, and TOD in 397 adolescents. ABP means standard deviation (SD), BP, and heart rate (HR) dipping were calculated; coefficients of variability (CV) were calculated (SD/mean) to assess ABP variabilities. Measures of TOD included LVMI, left ventricular hypertrophy (LVH), LV systolic shortening, LV diastolic function (e'/a'), and pulse wave velocity. General linear models were used to determine if increased ABP variability measures were significant determinants of TOD in models containing mean ABP percentiles, age, sex, race/ethnicity, BMI z-score, and HR.Results: Mean participant age was 15.6 ± 1.7 years (63% white, 59% male) with mean casual BP 122.6/71.6 mmHg ±12.4/10.5, and mean awake systolic ABP 124.2/72.0 ± 11.3/7.7 mmHg. In linear models, increased awake CV-DBP and HR dipping were significant determinants of LVMI. CV-HR was an independent determinant of diastolic (e'/a') but not systolic dysfunction. Using logistic regression, the combination of awake and asleep diastolic ABP variability and awake systolic ABP percentile improved the prediction of LVH.Conclusions: Consideration of ABP variability in addition to ABP percentile may aid in identifying adolescents at risk for LVH.","PeriodicalId":19735,"journal":{"name":"Pediatric Nephrology","volume":" ","pages":"157-165"},"PeriodicalIF":2.6,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12416511/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144094356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Response to critical appraisal of "Thiamin deficiency in children with chronic kidney disease on peritoneal dialysis and its association with dialysis duration and transport peritoneal membrane status". 对“慢性肾病腹膜透析患儿硫胺素缺乏症及其与透析持续时间和腹膜转运状态的关系”批评性评价的回应。

IF 2.6 3区医学

Pediatric Nephrology Pub Date : 2026-12-01 Epub Date: 2025-10-07 DOI: 10.1007/s00467-025-06992-y

Phakwan Laohathai, Narumon Densupsoontorn

引用次数: 0

Real-time driver activity detection using advanced deep learning models. 使用先进的深度学习模型进行实时驾驶员活动检测。

IF 3.9 3区工程技术

Cognitive Neurodynamics Pub Date : 2026-12-01 Epub Date: 2025-11-14 DOI: 10.1007/s11571-025-10376-1

Md Al Emran, Md Ariful Islam, Md Obaydullahn Khan, Md Jewel Rana, Saida Tasnim Adrita, Md Ashik Ahmed, Mahmoud M A Eid, Ahmed Nabih Zaki Rashed

{"title":"Real-time driver activity detection using advanced deep learning models.","authors":"Md Al Emran, Md Ariful Islam, Md Obaydullahn Khan, Md Jewel Rana, Saida Tasnim Adrita, Md Ashik Ahmed, Mahmoud M A Eid, Ahmed Nabih Zaki Rashed","doi":"10.1007/s11571-025-10376-1","DOIUrl":"https://doi.org/10.1007/s11571-025-10376-1","url":null,"abstract":"Traffic accidents usually result from driver's inattention, sleepiness, and distraction, posing a substantial danger to worldwide road safety. Advances in computer vision and artificial intelligence (AI) have provided new prospects for designing real-time driver monitoring systems to reduce these dangers. In this paper, we assessed four known deep learning models, MobileNetV2, DenseNet201, NASNetMobile, and VGG19, and offer a unique Hybrid CNN-Transformer architecture reinforced with Efficient Channel Attention (ECA) for multi-class driver activity categorization. The framework defines seven important driving behaviors: Closed Eye, Open Eye, Dangerous Driving, Distracted Driving, Drinking, Yawning, and Safe Driving. Among the baseline models, DenseNet201 (99.40%) and MobileNetV2 (99.31%) achieved the highest validation accuracies. In contrast, the proposed Hybrid CNN-Transformer with ECA attained a near-perfect validation accuracy of 99.72% and further demonstrated flawless generalization with 100% accuracy on the independent test set. Confusion matrix studies further indicate a few misclassifications, verifying the model's high generalization capacity. By merging CNN-based local feature extraction, attention-driven feature refinement, and Transformer-based global context modeling, the system provides both robustness and efficiency. These findings show the practicality of using the suggested technology in real-time intelligent transportation applications, presenting a viable avenue toward reducing traffic accidents and boosting overall road safety.","PeriodicalId":10500,"journal":{"name":"Cognitive Neurodynamics","volume":"20 1","pages":"7"},"PeriodicalIF":3.9,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12618750/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145538985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A dual brain EEG examination of the effects of direct and vicarious rewards on bilingual Language control. 直接和间接奖励对双语语言控制影响的双脑脑电图检查。

IF 3.9 3区工程技术

Cognitive Neurodynamics Pub Date : 2026-12-01 Epub Date: 2025-11-12 DOI: 10.1007/s11571-025-10375-2

Junjun Huang, Shuang Liu, Mengjie Lv, John W Schwieter, Huanhuan Liu

引用次数: 0

Membranous-like glomerulopathy with masked IgG-k deposits in a pediatric patient with juvenile idiopathic arthritis. 膜样肾小球病伴隐蔽性IgG-k沉积1例小儿特发性关节炎。

IF 2.6 3区医学

Pediatric Nephrology Pub Date : 2026-12-01 Epub Date: 2025-09-15 DOI: 10.1007/s00467-025-06954-4

Priyanka Chati, Jill Krissberg, Kammi Henriksen, Brian Nolan, Meredith Harris

引用次数: 0

Autophagy and ubiquitination in important swine viral infections: Host defense and viral antagonism. 重要的猪病毒感染中的自噬和泛素化：宿主防御和病毒拮抗。