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Recent advances in peptide macrocyclization strategies. 多肽大环化策略的最新进展。

IF 40.4 1区化学

Chemical Society Reviews Pub Date : 2024-11-19 DOI: 10.1039/d3cs01066j

Pengyuan Fang, Wing-Ka Pang, Shouhu Xuan, Wai-Lun Chan, Ken Cham-Fai Leung

{"title":"Recent advances in peptide macrocyclization strategies.","authors":"Pengyuan Fang, Wing-Ka Pang, Shouhu Xuan, Wai-Lun Chan, Ken Cham-Fai Leung","doi":"10.1039/d3cs01066j","DOIUrl":"https://doi.org/10.1039/d3cs01066j","url":null,"abstract":"Recently, owing to their special spatial structures, peptide-based macrocycles have shown tremendous promise and aroused great interest in multidisciplinary research ranging from potent antibiotics against resistant strains to functional biomaterials with novel properties. Besides traditional monocyclic peptides, many fascinating polycyclic and remarkable higher-order cyclic, spherical and cylindric peptidic systems have come into the limelight owing to breakthroughs in various chemical (e.g., native chemical ligation and transition metal catalysis), biological (e.g., post-translational enzymatic modification and genetic code reprogramming), and supramolecular (e.g., mechanically interlocked, metal-directed folding and self-assembly via noncovalent interactions) macrocyclization strategies developed in recent decades. In this tutorial review, diverse state-of-the-art macrocyclization methodologies and techniques for peptides and peptidomimetics are surveyed and discussed, with insights into their practical advantages and intrinsic limitations. Finally, the synthetic-technical aspects, current unresolved challenges, and outlook of this field are discussed.","PeriodicalId":68,"journal":{"name":"Chemical Society Reviews","volume":" ","pages":""},"PeriodicalIF":40.4,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142666649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bioorthogonally activated probes for precise fluorescence imaging. 用于精确荧光成像的生物正交激活探针。

IF 40.4 1区化学

Chemical Society Reviews Pub Date : 2024-11-18 DOI: 10.1039/d3cs00883e

Youxin Fu, Xing Zhang, Luling Wu, Miaomiao Wu, Tony D James, Run Zhang

引用次数: 0

A critical review on Li-ion transport, chemistry and structure of ceramic-polymer composite electrolytes for solid state batteries. 关于固态电池用陶瓷-聚合物复合电解质的锂离子传输、化学和结构的重要综述。

IF 40.4 1区化学

Chemical Society Reviews Pub Date : 2024-11-18 DOI: 10.1039/d4cs00214h

Sara Catherine Sand, Jennifer L M Rupp, Bilge Yildiz

{"title":"A critical review on Li-ion transport, chemistry and structure of ceramic-polymer composite electrolytes for solid state batteries.","authors":"Sara Catherine Sand, Jennifer L M Rupp, Bilge Yildiz","doi":"10.1039/d4cs00214h","DOIUrl":"https://doi.org/10.1039/d4cs00214h","url":null,"abstract":"In the transition to safer, more energy-dense solid state batteries, polymer-ceramic composite electrolytes may offer a potential route to achieve simultaneously high Li-ion conductivity and enhanced mechanical stability. Despite numerous studies on the polymer-ceramic composite electrolytes, disagreements persist on whether the polymer or the ceramic is positively impacted in their constituent ionic conductivity for such composite electrolytes, and even whether the interface is a blocking layer or a highly conductive lithium ion path. This lack of understanding limits the design of effective composite solid electrolytes. By thorough and critical analysis of the data collected in the field over the last three decades, we present arguments for lithium conduction through the bulk of the polymer, ceramic, or their interface. From this analysis, we can conclude that the unexpectedly high conductivity reported for some ceramic-polymer composites cannot be accounted for by the ceramic phase alone. There is evidence to support the theory that the Li-ion conductivity in the polymer phase increases along this interface in contact with the ceramic. The potential mechanisms for this include increased free volume, decreased crystallinity, and modulated Lewis acid-base effects in the polymer, with the former two to be the more likely mechanisms. Future work in this field requires understanding these factors more quantitatively, and tuning of the ceramic surface chemistry and morphology in order to obtain targeted structural modifications in the polymer phase.","PeriodicalId":68,"journal":{"name":"Chemical Society Reviews","volume":" ","pages":""},"PeriodicalIF":40.4,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142646083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0