Materials Horizons最新文献

{"title":"Using a stable radical as an \"electron donor\" to develop a radical photosensitizer for efficient type-I photodynamic therapy.","authors":"Xiao Cui, Fang Fang, Huan Chen, Chen Cao, Yafang Xiao, Shuang Tian, Jinfeng Zhang, Shengliang Li, Chun-Sing Lee","doi":"10.1039/d4mh00952e","DOIUrl":"https://doi.org/10.1039/d4mh00952e","url":null,"abstract":"<p><p>Among type I photosensitizers, stable organic radicals are superior candidate molecules for hypoxia-overcoming photodynamic therapy. However, their wide applications are limited by complicated preparation processes and poor stabilities. Herein, a nitroxide radical was simply synthesized by introducing a commercially available \"TEMPO\" moiety. The radical exhibits efficient type-I ROS generation and appreciable photo-cytotoxicity under hypoxia, which open up a new avenue for the exploration of a novel and efficient type-I photosensitizer.</p>","PeriodicalId":87,"journal":{"name":"Materials Horizons","volume":" ","pages":""},"PeriodicalIF":12.2,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142666653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hydrogen sulfide-generating semiconducting polymer nanoparticles for amplified radiodynamic-ferroptosis therapy of orthotopic glioblastoma.","authors":"Anni Zhu, Shuai Shao, Jinyuan Hu, Wenzhi Tu, Zheming Song, Yue Liu, Jiansheng Liu, Qin Zhang, Jingchao Li","doi":"10.1039/d4mh01356e","DOIUrl":"https://doi.org/10.1039/d4mh01356e","url":null,"abstract":"<p><p>A variety of therapeutic strategies are available to treat glioblastoma (GBM), but the tumor remains one of the deadliest due to its aggressive invasiveness, restrictive blood-brain barrier (BBB), and exceptional resistance to drugs. In this study, we present a hydrogen sulfide (H₂S)-generating semiconducting polymer nanoparticle (PFeD@Ang) for amplified radiodynamic-ferroptosis therapy of orthotopic glioblastoma. Our results show that in an acidic tumor microenvironment (TME), H₂S donors produce large amounts of H₂S, which inhibits mitochondrial respiration and alleviates cellular hypoxia, thus enhancing the radiodynamic effect during X-ray irradiation; meanwhile, Fe³⁺ is reduced to Fe²⁺ by tannic acid in an acidic TME, which promotes an iron-dependent cell death process in tumors. H₂S facilitates the ferroptosis process by increasing the local H₂O₂ concentration <i>via</i> inhibiting catalase activity. This kind of amplified radiodynamic-ferroptosis therapeutic strategy could remarkably inhibit glioma progression in an orthotopic GBM mouse model. Our study demonstrates the potential of PFeD@Ang for GBM treatment <i>via</i> targeted delivery and combinational therapeutic actions of RDT and ferroptosis therapy.</p>","PeriodicalId":87,"journal":{"name":"Materials Horizons","volume":" ","pages":""},"PeriodicalIF":12.2,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142646124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biological metasurfaces based on tailored Luria Bertani Agar growth medium formulations for photonic applications.","authors":"Francesca Leone, Olga Favale, Mauro Daniel Luigi Bruno, Roberto Bartolino, Ferdinanda Annesi, Vincenzo Caligiuri, Antonio De Luca","doi":"10.1039/d4mh00861h","DOIUrl":"https://doi.org/10.1039/d4mh00861h","url":null,"abstract":"<p><p>Biodegradable alternatives to classic solid-state components are rapidly taking place in front-end photonic systems like metamaterials, meta-surfaces and photonic crystals. From this point of view, numerous solutions have been proposed involving eco-friendly compounds. Among them, the Luria Bertani agar (LBA) growth medium has been recently proposed as a functional option with the remarkable advantage of allowing the growth of fluorescent protein expressing bacteria. Such a possibility promises to lead to development of a new generation of biological and eco-sustainable optical sources based on meta-surfaces. There is, however, still a main drawback to address, related to the highly scattering nature of these compounds. To ensure adequate nutritive elements for cell growth, LBA hosts several compounds like NaCl, yeast extracts and tryptone. The presence of these components leads to very scattering LBA films, thus hindering its performance as an optical polymer. A trade-off arises between nutritive capacity and optical performance. In this paper, we successfully address this trade-off, demonstrating that a reduction of the basic nutrients (net Agar concentration) of LBA largely enhances the optical properties of the film as a photonic polymer without compromising its cell-viability. We considered two new LBA formulations with two- (LB₂A) and four-fold (LB₄A) reduction of the nutrients and replicated a square-lattice meta-surface used as a benchmark architecture. We demonstrated that both the replica molding performances and the optical properties (absorption, scattering and diffraction efficiency) of LBA formulations increase with decreasing nutrient concentration, without losing their cell-growth capability. To demonstrate this fundamental aspect, we inoculated the most critical case of LB₄A with green-fluorescent-protein-expressing <i>E. coli</i> bacteria, verifying both their vitality and good photoluminescence properties. These results overcome one of the main limitations of LBA as a functional biopolymer for optical applications, unlocking its use in a new generation of biological quantum optical frameworks for all-biological weak and strong light-matter interactions.</p>","PeriodicalId":87,"journal":{"name":"Materials Horizons","volume":" ","pages":""},"PeriodicalIF":12.2,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142646122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeted and precise drug delivery using a glutathione-responsive ultra-short peptide-based injectable hydrogel as a breast cancer cure.","authors":"Satyajit Halder, Tanushree Das, Ritvika Kushwaha, Anup Kumar Misra, Kuladip Jana, Debapratim Das","doi":"10.1039/d4mh00981a","DOIUrl":"https://doi.org/10.1039/d4mh00981a","url":null,"abstract":"<p><p>Harnessing the potential of hydrogel-based localized drug delivery systems holds immense promise for mitigating the systemic side effects associated with conventional cancer therapies. However, the development of such systems demands the fulfillment of multiple stringent criteria, including injectability, biocompatibility, and controlled release. Herein, we present an ultra-small peptide-based hydrogel for the sustained and targeted delivery of doxorubicin in a murine model of breast cancer. The hydrogel evades dissolution and remains stable in biological fluids, serving as a reliable drug reservoir. However, it specifically reacts to the high levels of glutathione (GSH) in the tumor microenvironment and releases drugs in a controlled manner over time for consistent therapeutic benefits. Remarkably, administration of a single dose of doxorubicin-loaded hydrogel elicited superior tumor regression (approximately 75% within 18 days) compared to conventional doxorubicin treatment alone. Furthermore, the persistent presence of the drug-loaded hydrogel near the tumor site for up to 18 days after administration highlights its enduring effectiveness. There is great clinical potential for this localized delivery strategy because of the minimal off-target effects on healthy tissues. Our findings underscore the efficacy of this smart peptide-hydrogel platform and pave the way for developing next-generation localized drug delivery systems with enhanced therapeutic outcomes in cancer treatment.</p>","PeriodicalId":87,"journal":{"name":"Materials Horizons","volume":" ","pages":""},"PeriodicalIF":12.2,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142646126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-performance chemically recyclable multifunctional polyolefin-like biomass-derived polyester materials.","authors":"Zheng-Ming Li, Xing-Liang Li, Yao Li, Yu-Hang Zhang, Teng Fu, Xiu-Li Wang, Yu-Zhong Wang","doi":"10.1039/d4mh01203h","DOIUrl":"10.1039/d4mh01203h","url":null,"abstract":"<p><p>Polyolefins are the most widely used and produced petroleum-based plastics. Unfortunately, the enormous production and usage of traditional polyolefins, coupled with the lack of effective disposal or recycling options, have led to significant fossil fuel depletion and severe environmental pollution. To foster sustainable societal development, there is an urgent need to design high-performance and inherently recyclable polyolefin-like bio-derived materials by innovative structural and molecular designs. Here, inspired by a copolymerization molecular design approach that simultaneously confers recyclability and superior properties to materials, high-performance recyclable polyolefin-like bio-derived polyesters (PBC_<i>x</i>S) enabled by a novel judicious combination of building blocks are reported. PBC_<i>x</i>S display excellent mechanical (40.6 MPa, 498.4%) and gas barrier properties (O₂ 0.09 barrer, H₂O 1.70 × 10^-13 g cm cm^-2 s^-1 Pa^-1), even greater than those of bio-based materials and most aliphatic polyester. Meanwhile, PBC_<i>x</i>S also exhibit multifunctionality with excellent biocompatibility properties and ultra-high processability (thermoforming, extrusion spinning, and 3D printing processing). Notably, PBC_<i>x</i>S undergo depolymerization in the absence of any additional organic solvents, regenerating 92.0% of the high-purity (98.3%) original monomers, even with polyolefin blend plastics. Repolymerized polyesters still maintain their exceptional mechanical and thermal qualities. The successful application of this approach in polyesters opens up exciting possibilities for designing high-performance and recyclable bio-derived polyolefin-like materials.</p>","PeriodicalId":87,"journal":{"name":"Materials Horizons","volume":" ","pages":""},"PeriodicalIF":12.2,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142613031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nano-enabled dynamically responsive living acellular hydrogels.","authors":"Roya Koshani, Sina Kheirabadi, Amir Sheikhi","doi":"10.1039/d4mh00922c","DOIUrl":"https://doi.org/10.1039/d4mh00922c","url":null,"abstract":"<p><p>As a key building block of mammalian tissues, extracellular matrices (ECMs) stiffen under shear deformation and undergo cell-imparted healing after damage, features that regulate cell fate, communication, and survival. The shear-stiffening behavior is attributed to semi-flexible biopolymeric ECM networks. Inspired by the mechanical behavior of ECMs, we develop acellular nanocomposite living hydrogels (LivGels), comprising network-forming biopolymers and anisotropic hairy nanoparticle linkers that mimic the dynamic mechanical properties of living counterparts. We show that a bifunctional dynamic linker nanoparticle (nLinker), bearing semi-flexible aldehyde- and carboxylate-modified cellulose chains attached to rigid cellulose nanocrystals converts bulk hydrogels to ECM-like analogues <i>via</i> ionic and dynamic covalent hydrazone bonds. The nLinker not only enables the manipulation of nonlinear mechanics and stiffness within the biological window, but also imparts self-healing to the LivGels. This work is a step forward in designing living acellular soft materials with complex dynamic properties using bio-based nanotechnology.</p>","PeriodicalId":87,"journal":{"name":"Materials Horizons","volume":" ","pages":""},"PeriodicalIF":12.2,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142637942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Framing emission gain layers for perovskite light-emitting diodes using polycaprolactone-silver nanoparticles featuring Förster resonance energy transfer and Purcell effects.","authors":"Zhen-Li Yan, Guan-De Wu, Chu-Chen Chueh, Ying-Chi Huang, Bi-Hsuan Lin, Jia-Hau Tsai, Mei-Hsin Chen, Zong-Liang Tseng, Ye Zhou, Ru-Jong Jeng, Chi-Ching Kuo","doi":"10.1039/d4mh01268b","DOIUrl":"10.1039/d4mh01268b","url":null,"abstract":"<p><p>In this study, a new emission gain layer for perovskite light-emitting diodes (PeLEDs) is presented to improve their performance. The emission gain layer consisting of absorption-stable silver nanoparticles is prepared using the post-addition method of the polycaprolactone capping agent (PCL@AgNPs-P). This layer (PCL@AgNPs-P) effectively improves the Förster resonance energy transfer (FRET) between the low-<i>n</i> (minor) and high-<i>n</i> (major) phases in a quasi2D perovskite system, thereby increasing the major emission intensity and efficiency. Moreover, this layer also enhances the Purcell effect, thus increasing the spontaneous emission rates and amplifying the electroluminescence. These combined advantages enable the derived PeLED to achieve higher luminance, external quantum efficiency (EQE), and sustained emission purity. As a result, the optimized PeLED with the PCL@AgNPs-P emission gain layer delivers a maximum luminance of 11 320 cd m^-2 and an EQE of 15.5%, and maintains high green wavelength emission purity and a narrow emission half-maximum width at various operating currents. Our results not only provide a robust pathway for the development of high-performance PeLEDs, but also open up the possibilities of applying PeLEDs in laser optics, where enhanced efficiency and emission characteristics are crucial for creating efficient and high-emission laser sources.</p>","PeriodicalId":87,"journal":{"name":"Materials Horizons","volume":" ","pages":""},"PeriodicalIF":12.2,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142613025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cu-incorporated NH₂-MIL-125(Ti): a versatile visible-light-driven platform for enhanced photocatalytic H₂ generation and CO₂ photoconversion.","authors":"Anna Pancielejko, Mateusz A Baluk, Hanna Zagórska, Magdalena Miodyńska-Melzer, Anna Gołąbiewska, Tomasz Klimczuk, Mirosław Krawczyk, Mirosława Pawlyta, Krzysztof Matus, Alicja Mikolajczyk, Henry P Pinto, Aleksandra Pieczyńska, Joanna Dołżonek, Adriana Zaleska-Medynska","doi":"10.1039/d4mh01116c","DOIUrl":"https://doi.org/10.1039/d4mh01116c","url":null,"abstract":"<p><p>Here, we present for the first time an efficient platform for simultaneous H₂ generation and CO₂ conversion into HCOOH, utilizing a Cu-incorporated NH₂-MIL-125(Ti) material with triethanolamine as the sacrificial agent. When subjected to light, Cu-NH₂-MIL-125(Ti) exhibits a remarkable enhancement in H₂ generation, with a 30-fold increase under UV-Vis light and an 8-fold increase under visible irradiation compared to the pristine MOF. The study on the CO₂ photoreduction ability of Cu-NH₂-MIL-125(Ti) indicated successful conversion into formic acid yielding 62.4 μmol g_cat^-1 under visible irradiation. This notable improvement in photocatalytic activity can be attributed to the heightened light absorption capacity and efficient charge transportation and separation mechanisms inherent in Cu-NH₂-MIL-125(Ti). Furthermore, the stability of the Cu-NH₂-MIL-125(Ti) photocatalyst remains steady even after 24 hours of continuous irradiation. The theoretical simulations suggest that Cu introduction effectively reduces the bandgap while leaving the position and composition of the valence band unaffected.</p>","PeriodicalId":87,"journal":{"name":"Materials Horizons","volume":" ","pages":""},"PeriodicalIF":12.2,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142637941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Precise weight tuning in quantum dot-based resistive-switching memory for neuromorphic systems.","authors":"Gyeongpyo Kim, Doheon Yoo, Hyojin So, Seoyoung Park, Sungjoon Kim, Min-Jae Choi, Sungjun Kim","doi":"10.1039/d4mh01182a","DOIUrl":"https://doi.org/10.1039/d4mh01182a","url":null,"abstract":"<p><p>In this study, nonvolatile bipolar resistive switching and synaptic emulation behaviors are performed in an InGaP quantum dots (QDs)/HfO₂-based memristor device. First, the physical and chemical properties of InGaP QDs are investigated by high-resolution transmission electron microscopy and spectrophotometric analysis. Through comparative experiments, it is proven that the HfO₂ layer improves the variations in resistive switching characteristics. Additionally, the Al/QDs/HfO₂/ITO device exhibits reversible switching performances with excellent data retention. Fast switching speeds in the order of nanoseconds were confirmed, which could be explained by trapping/detrapping and quantum tunneling effects by the trap provided by nanoscale InGaP QDs. In addition, the operating voltage is decreased when the device is exposed to ultraviolet light for low-power switching. Biological synapse features such as spike-timing-dependent plasticity are emulated for neuromorphic systems. Finally, the incremental step pulse using proven algorithm method enabled the implementation of four-bit states (16 states), markedly enhancing the inference precision of neuromorphic systems.</p>","PeriodicalId":87,"journal":{"name":"Materials Horizons","volume":" ","pages":""},"PeriodicalIF":12.2,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142613037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reduction-immobilizing strategy of polymer-embedded sub-2 nm Cu nanoparticles with uniform size and distribution responsible for robust catalytic reactions.","authors":"Rosy Amalia Kurnia Putri, Wail Al Zoubi, Bassem Assfour, Abdul Wahab Allaf, Sudiyarmanto, Young Gun Ko","doi":"10.1039/d4mh01220h","DOIUrl":"https://doi.org/10.1039/d4mh01220h","url":null,"abstract":"<p><p>Polymer-embedded metal nanoparticles are in great demand owing to their unique features, leading to their use in various important applications, including catalysis reactions. However, particle sintering and aggregation are serious drawbacks, resulting in a drastic loss of catalytic activity and recyclability. Herein, a reduction-immobilizing strategy of polymer-embedded sub-2 nm Cu nanoparticles offered highly controlled distribution and nanoparticle size within polymer structures with high fidelity. This work sheds light on the high catalytic performance of nanoparticles that rely on their ultrasmall size and uniform distribution in polymer structures, generating more active sites that result in high efficiency reduction of organic compounds. A catalysis study was carried out for the hydrogenation of nitro compounds, achieving nearly 100% reduction in an extremely short time and remaining stable after 15 consecutive cycles. Furthermore, the catalytic mechanism was demonstrated by density functional theory (DFT) calculations. Notably, the discovery of this facile strategy may enable the remarkable cutting-edge design of catalyst materials with promising performance and stability.</p>","PeriodicalId":87,"journal":{"name":"Materials Horizons","volume":" ","pages":""},"PeriodicalIF":12.2,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142613038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}