Polymer Chemistry最新文献

Precision synthesis of biobased myrcene thermoplastic elastomer by using amphiphilic macro-RAFT agent via emulsion polymerization in aqueous medium

IF 4.6 2区化学

Polymer Chemistry Pub Date : 2024-06-27 DOI: 10.1039/d4py00093e

Wen Li, Guoyu Chen, Youfang Zhang, Jianyun Ding, Jie Liu, Runguo Wang, Dean Shi, Weiwei Lei, Liqun Zhang

{"title":"Precision synthesis of biobased myrcene thermoplastic elastomer by using amphiphilic macro-RAFT agent via emulsion polymerization in aqueous medium","authors":"Wen Li, Guoyu Chen, Youfang Zhang, Jianyun Ding, Jie Liu, Runguo Wang, Dean Shi, Weiwei Lei, Liqun Zhang","doi":"10.1039/d4py00093e","DOIUrl":"https://doi.org/10.1039/d4py00093e","url":null,"abstract":"In recent years, myrcene has been emerged as a biobased alternative to isoprene for the manufacture of thermoplastic elastomers due to its similarity to isoprene, a building block for natural rubber. Through the use of highly reactive tert-butyl acrylate as a hard segment monomer, a structurally well-defined poly(tert-butyl acrylate)-b-poly(β-myrcene)-b-poly(tert-butyl acrylate) (BMB) thermoplastic triblock copolymer elastomer, was synthesized by a mild reversible addition-fragmentation chain transfer (RAFT) emulsion polymerization method utilizing a precisely devised amphiphilic macro-RAFT agent. The block copolymer BMB was confirmed by NMR, FTIR, and GPC analysis. BMB thus exhibits typical thermoplastic elastomeric properties, as indicated by its mechanical properties with an ultimate tensile strength of 3.0 MPa and an elongation at break of 195% at a tert-butyl acrylate added of 50% mass ratio. The properties of BMB can be easily tuned by adjusting hydrolysis degree, facilitating cooperative interactions in hard phase and enhancing tensile properties. This carboxyl interaction is an effective strategy for controlling the medium strength thermoplastic elastomers.","PeriodicalId":100,"journal":{"name":"Polymer Chemistry","volume":null,"pages":null},"PeriodicalIF":4.6,"publicationDate":"2024-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141461857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Kinetic investigation of photoiniferter-RAFT polymerization in continuous flow using inline NMR analysis

IF 4.6 2区化学

Polymer Chemistry Pub Date : 2024-06-26 DOI: 10.1039/d4py00409d

Magdalena A Beres, Bo Zhang, Tanja Junkers, Sébastien Perrier

{"title":"Kinetic investigation of photoiniferter-RAFT polymerization in continuous flow using inline NMR analysis","authors":"Magdalena A Beres, Bo Zhang, Tanja Junkers, Sébastien Perrier","doi":"10.1039/d4py00409d","DOIUrl":"https://doi.org/10.1039/d4py00409d","url":null,"abstract":"Photo Reversible Deactivation Radical Polymerization, and in particular photoiniferter - Reversible Addition−Fragmentation chain Transfer (PI-RAFT) polymerisation have become popular approaches to polymer synthesis in recent years. There is however a lack of fundamental investigations concerning mechanism and kinetics of such reactions. Herein, we apply an automated continuous flow platform featuring inline NMR analysis which allows for rapid kinetic screening via transient timesweep experiments for detailed investigation of PI-RAFT of two model monomers with different propagation rates and radical stability – methyl acrylate (MA) and methyl methacrylate (MMA). The effect of structure of RAFT agent on polymerization kinetics is studied. For polymerization of MA, RAFT agents with more stabilised R group lead to induction period which extent can be tuned by varying light intensity. Faster polymerization of MA with xanthates than trithiocarbonates suggest important role of reversible termination in PI-RAFT mechanism. Slower apparent rate of propagation for polymerization of acrylates when compared to polymerization of methacrylates, when mediated by trithiocarbonate RAFT agents, indicates that polymerization of MA is retarded due to lower radical stability of propagating radical compared to methacrylic radicals.","PeriodicalId":100,"journal":{"name":"Polymer Chemistry","volume":null,"pages":null},"PeriodicalIF":4.6,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141461933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synergistic Chemotherapy/Photothermal Therapy for Cancer Treatment Using a Co-Delivery System of Cisplatin and Novel Conjugated Polymers

IF 4.6 2区化学

Polymer Chemistry Pub Date : 2024-06-26 DOI: 10.1039/d4py00502c

Yaodong Di, Hanning Zhang, Zimu Luo, Congshu Feng, Xi Zhang, Shuai Yang, Jie Hou, Lesan Yan

{"title":"Synergistic Chemotherapy/Photothermal Therapy for Cancer Treatment Using a Co-Delivery System of Cisplatin and Novel Conjugated Polymers","authors":"Yaodong Di, Hanning Zhang, Zimu Luo, Congshu Feng, Xi Zhang, Shuai Yang, Jie Hou, Lesan Yan","doi":"10.1039/d4py00502c","DOIUrl":"https://doi.org/10.1039/d4py00502c","url":null,"abstract":"In tumor treatment, traditional single therapies such as chemotherapy or photothermal therapy often suppress tumor growth while also causing serious toxic side effects on normal tissues and organs. Additionally, reducing drug dosage is challenging to achieve the desired therapeutic effects. Therefore, combining chemotherapy and photothermal therapy has become an effective strategy to enhance tumor treatment efficiency. To achieve this, a biodegradable amphiphilic block copolymer with carboxyl-functionalized side chains, named mPEG-b-P(CL-co-MPC/TMA), was designed and synthesized. It was then complexed with cisplatin to successfully prepare mPEG-b-P(CL-co-MPC/TMA)-Pt. Subsequently, the novel conjugated polymer photothermal agent PDPPDTP was encapsulated to prepare PDPPDTP-loaded mPEG-b-P(CL-co-MPC/TMA)-Pt nanomicelles. These nanomicelles not only co-deliver cisplatin drugs and photothermal agents but also exhibit excellent stability and photothermal performance. Under lower doses of cisplatin drugs and photothermal effects, they can still efficiently eradicate tumor cells in a relatively gentle manner, demonstrating significant potential in synergistic cancer therapy.","PeriodicalId":100,"journal":{"name":"Polymer Chemistry","volume":null,"pages":null},"PeriodicalIF":4.6,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141461781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Radical Polymerisation and Thiol-Ene Post-Polymerisation Functionalisation of Terpenoid Acrylates in Conventional and Renewably Sourced Organic Solvents

IF 4.6 2区化学

Polymer Chemistry Pub Date : 2024-06-25 DOI: 10.1039/d4py00340c

David M Haddleton, Huizhe Liu, Vincent Maugein

{"title":"Radical Polymerisation and Thiol-Ene Post-Polymerisation Functionalisation of Terpenoid Acrylates in Conventional and Renewably Sourced Organic Solvents","authors":"David M Haddleton, Huizhe Liu, Vincent Maugein","doi":"10.1039/d4py00340c","DOIUrl":"https://doi.org/10.1039/d4py00340c","url":null,"abstract":"Geranyl acrylate, has been synthesized and polymerized by various radical polymerisation techniques. Due to the structural diversity, a number of post polymerisation functionalization options were explored. Monomer conversion, polymer structure and the molecular weight were assessed by NMR, FT-IR and size exclusion chromatography (SEC). Free radical polymerization and Cu-mediated reversible deactivation radical polymerization (RDRP) were used to synthesise poly(geranyl acrylate) of various molecular weight in both conventional petro derived organic and bio-based renewably sourced solvents. Cu0 wire-mediated RDRP was found to be a suitable polymerisation method when compared to CuII-mediated photoinduced RDRP giving the optimal living radical polymerisation method for the synthesis of poly(geranyl acrylate) in Cyrene (Mn, SEC = 3000, ĐSEC = 1.25). The residual allylic double bonds provided a useful option for post-polymerization modification. Poly(geranyl acrylate) was subjected to a photoinduced thiol-ene reactions, using different thiols with a variety of functional groups. The success of the functionalization reaction was evaluated by NMR, FT-IR spectroscopy, and SEC. In addition, differential scanning calorimetry was used to investigate changes in the thermal properties of the polymer, before and after thiol-ene functionalization.","PeriodicalId":100,"journal":{"name":"Polymer Chemistry","volume":null,"pages":null},"PeriodicalIF":4.6,"publicationDate":"2024-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141461800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preparation and Characterization of Temperature/pH/CO2-Triple-Responsive Homopolymers and Their Substituents Determined Response

IF 4.6 2区化学

Polymer Chemistry Pub Date : 2024-06-25 DOI: 10.1039/d4py00509k

Ke Wang, Zilong Wang, Meiyu Si, Xiaofang Liu, Guiyan Liu, Yongfei Zeng

{"title":"Preparation and Characterization of Temperature/pH/CO2-Triple-Responsive Homopolymers and Their Substituents Determined Response","authors":"Ke Wang, Zilong Wang, Meiyu Si, Xiaofang Liu, Guiyan Liu, Yongfei Zeng","doi":"10.1039/d4py00509k","DOIUrl":"https://doi.org/10.1039/d4py00509k","url":null,"abstract":"Three novel temperature/pH/CO2-triple-responsive homopolymers namely P(Et-N-EO2MA), P(THP-N-EO2MA) and P(Ph-N-EO2MA) were prepared by reversible addition-fragmentation chain transfer (RAFT) polymerization. They have the same structure of backbone, but different types of end substituents of ethyl, tetrahydropyrane, and benzene ring, respectively. Subsequently, the properties of their responses were studied. P(Et-N-EO2MA) has a lower critical solution temperature (LCST)-type cloud point (CP) temperature in aqueous solution and is affected by many factors such as molecular structure and weight, concentration, additives, pH and CO2. P(THP-N-EO2MA) is soluble in water, but in different buffer solution, it shows the evolution of soluble-LCST-insoluble, and LCST-type CP can also be adjusted by molecular weight and concentration. P(Ph-N-EO2MA) is insoluble in water, but reversible phase transformation can be achieved by adjusting the pH of the solution or injecting CO2, and it also shows different properties in buffer solutions and an upper critical solution temperature (UCST)-type CP in n-butanol. In addition, since P(Ph-N-EO2MA) is amphiphilic, it can be self-assembled in solution, and the release of Nile Red (NR) can be achieved under the stimulation of acid. The different properties of these homopolymers show the effects of substituents on the responsiveness of multistimuli-responsive polymers which provide ideas for the design of stimuli-responsive polymers, and have good application prospects in the field of self-assembly and controlled release.","PeriodicalId":100,"journal":{"name":"Polymer Chemistry","volume":null,"pages":null},"PeriodicalIF":4.6,"publicationDate":"2024-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141461608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advancing nucleic acid delivery through cationic polymer design: non-cationic building blocks from the toolbox

IF 4.6 2区化学

Polymer Chemistry Pub Date : 2024-06-24 DOI: 10.1039/d4py00234b

Ilaria Porello, Nina Bono, Gabriele Candiani, Francesco Cellesi

{"title":"Advancing nucleic acid delivery through cationic polymer design: non-cationic building blocks from the toolbox","authors":"Ilaria Porello, Nina Bono, Gabriele Candiani, Francesco Cellesi","doi":"10.1039/d4py00234b","DOIUrl":"https://doi.org/10.1039/d4py00234b","url":null,"abstract":"Polymers used for the delivery of nucleic acids (NAs) typically possess ionizable, cationic moieties enabling their electrostatic interaction with negatively charged NAs and form stable polyplexes. However, non-cationic building blocks have been harnessed to design cationic polymers with enhanced delivery of DNA/RNA to tissues, cells, and subcellular compartments while remaining stable in biological fluids. By customizing the chemistry of these functional groups, we can improve cell targeting behavior, uptake, endosomal escape, non-toxicity, and transfection efficiency. Additionally, the physicochemical properties such as the loading capacity, complexation ability, size and morphology, biodegradability, pH sensitivity, and amphiphilicity can be adjusted based on the specific application. This review summarizes the role of non-cationic moieties in various biomedical contexts, from therapeutic interventions to gene editing. By unpacking and critically summarizing the existing literature, this review provides valuable insights into the rational integration of these building blocks for designing more effective nanovectors to deliver NAs.","PeriodicalId":100,"journal":{"name":"Polymer Chemistry","volume":null,"pages":null},"PeriodicalIF":4.6,"publicationDate":"2024-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141461905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optimizing Stability through Conformational Locking and Ring Fusion Modulation in Organic Semiconductors

IF 4.6 2区化学

Polymer Chemistry Pub Date : 2024-06-24 DOI: 10.1039/d4py00246f

Salahuddin S. Attar, Bahattin Bademci, Maciej Barłóg, Dusan Nikola Sredojevic, Hessa Al-Thani, Sandra Dudley, Konstantinos Kakosimos, Hassan S Bazzi, Muhammad Tariq Sajjad, Mohammed Al-Hashimi

{"title":"Optimizing Stability through Conformational Locking and Ring Fusion Modulation in Organic Semiconductors","authors":"Salahuddin S. Attar, Bahattin Bademci, Maciej Barłóg, Dusan Nikola Sredojevic, Hessa Al-Thani, Sandra Dudley, Konstantinos Kakosimos, Hassan S Bazzi, Muhammad Tariq Sajjad, Mohammed Al-Hashimi","doi":"10.1039/d4py00246f","DOIUrl":"https://doi.org/10.1039/d4py00246f","url":null,"abstract":"The newly synthesized fused tetrathienophenanthroline (TTP) acceptor molecule, achieved via one-pot super acid catalyzed intramolecular cyclization, offers a promising alternative to the conventional benzodithiophene-4,8-dione (BDD) moieties in high-performance photovoltaic materials. The S, N heteroacene type TTP core exhibits complete planarity and enhanced electron richness compared to the BDD core, paving the way for fine tuning the morphological, optoelectronic, and frontier molecular energy levels in donor-acceptor-type materials. Side-chain engineering resulted in a balanced electron-rich nature of the monomer and the enhanced solubility/processability of the resulting polymers. These molecular strategies in PTTP-BDT contribute to improved stability and morphology, crucial for organic electronic device applications. Incorporating PTTP-BDT and PBDB-T as donor molecules in organic photovoltaics resulted in-power conversion efficiency (PCE) of ~ 3% for PTTP-BDT and ~8% for PBDB-T. The compromise in PTTP-BDT based device efficiency was attributed to lower and unbalanced charge mobility","PeriodicalId":100,"journal":{"name":"Polymer Chemistry","volume":null,"pages":null},"PeriodicalIF":4.6,"publicationDate":"2024-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141461911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A luminescent supramolecular polymer based on a stiff-stilbene bridged pillar[5]arene as a Pd2+-responsive smart material

IF 4.6 2区化学

Polymer Chemistry Pub Date : 2024-06-24 DOI: 10.1039/d4py00426d

Jing Wu, Chuanyun Liang, Jianyi Zhao, Han Zuilhof, Hongxia Zhao

引用次数: 0

Water-Based Polymer Colloids with a Branched Chain Architecture as Low-Gel Pressure-Sensitive Adhesives 具有支链结构的水基聚合物胶体作为低凝胶压敏粘合剂

IF 4.6 2区化学

Polymer Chemistry Pub Date : 2024-06-19 DOI: 10.1039/d4py00522h

Emily May Brogden, Stefan A. F. Bon

引用次数: 0

One-step preparation of hydrophilic–hydrophobic asymmetric bilayer microcapsules via photopolymerization† 通过光聚合一步制备亲水-疏水不对称双层微胶囊

IF 4.1 2区化学

Polymer Chemistry Pub Date : 2024-06-18 DOI: 10.1039/d4py00377b

Kaiyun Wu , Yongbin He , Jiangqing Liu , Guanqing Sun , Ren Liu , Jing Luo

引用次数: 0