ACS Applied Nano Materials最新文献

{"title":"Enrichment of 1.0 Nanometer Diameter Single-Chirality Single-Walled Carbon Nanotubes Dictated by Conjugated Polymer Characteristics: Implications for High-Performance Thin-Film Transistors","authors":"Jianying Ouyang*,&nbsp;Homin Shin,&nbsp;Paul Finnie,&nbsp;Jianfu Ding,&nbsp;Zhao Li,&nbsp;Brendan Mirka and Patrick R. L. Malenfant,&nbsp;","doi":"10.1021/acsanm.5c0078310.1021/acsanm.5c00783","DOIUrl":"https://doi.org/10.1021/acsanm.5c00783https://doi.org/10.1021/acsanm.5c00783","url":null,"abstract":"<p >In conjugated polymer extraction (CPE), the polymer characteristics impact the chiral selectivity and yield in the enrichment of single-chirality, single-walled carbon nanotubes (SWCNTs). Polyfluorene is one of the most efficient conjugated polymers to enrich semiconducting or single-chirality SWCNTs. We found that copolymers of fluorene and pyridine (PF12-Py2,5) or oxadiazole (P(F₄-alt-Ox)) exhibited a prevailing selectivity toward (8,7) (diameter 1.032 nm). The chiral purity of (8,7) was improved by storage and ultracentrifugation. In addition, <i>p</i>-xylene is better than toluene to achieve a higher selectivity; as a result, 66% (8,7) purity was reached in <i>p</i>-xylene. Furthermore, the length of the alkyl side chain in PF-Py2,5 also influences the selectivity, with the medium length (<i>n</i>-dodecylfluorene, PF12-Py2,5) showing higher (8,7) selectivity than a shorter length (<i>n</i>-octylfluorene, PF8-Py2,5) and a longer length (<i>n</i>-tetradecylfluorene, PF14-Py2,5). Besides, copolymers of fluorene and benzothiadiazole (PFO-BT) and anthracene (PFO=A) enriched (10,5) (diameter 1.050 nm) in <i>p</i>-xylene and (9,5) (diameter 0.976 nm) in toluene with their chiral purity up to 94.5% and 86%, respectively. The chiral purity was calculated based on the area percentage of the optical absorption S₁₁ peak and also evaluated by photoluminescence excitation (PLE) mapping and Raman scattering spectroscopy. All three (n,m) achieved the highest purity within the CPE methodology. The quality of enriched (8,7) was examined by the performance of thin-film transistors (TFT), which exhibited hole and electron mobilities of 2.6 ± 0.7 and 1.5 ± 0.6 cm²/(V s), respectively, and high on/off ratios of ∼10⁴. 1.0 nm diameter was suggested to reach balanced drive current and leakage in high-performance TFTs. Density functional theory calculation shows that polyfluorene exhibits increasing wrapping stability as the tube diameter increases, and the geometric model of polymer wrapping suggests that P(F₄-alt-Ox) has better coverage of nanotube surface toward (8,7).</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"8 16","pages":"8260–8273 8260–8273"},"PeriodicalIF":5.3,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acsanm.5c00783","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143867567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rod-Shaped Nanographenes as Emitters in Fluorescent OLEDs","authors":"Fabien Lucas*,&nbsp;Daniel Medina-Lopez,&nbsp;Cynthia Banga-Kpako,&nbsp;Thanh Trung Huynh,&nbsp;Jean-Sébastien Lauret and Stéphane Campidelli*,&nbsp;","doi":"10.1021/acsanm.5c0133210.1021/acsanm.5c01332","DOIUrl":"https://doi.org/10.1021/acsanm.5c01332https://doi.org/10.1021/acsanm.5c01332","url":null,"abstract":"<p >A significant challenge in the field of organic light-emitting diodes (OLEDs) technology is the development of stable, cost-effective, and sustainable emitters. Current emitters are frequently based on rare metals and heteroatom-based chromophores. Carbon-based nanomaterials, such as carbon dots (CDs) or nanographenes (NGs), offer a promising alternative due to their high photoluminescence quantum yields, the abundance of carbon materials, and the versatility of their syntheses. In this work, we fabricated green-light-emitting electroluminescent devices containing <b>C</b>_<b>60</b><b>-</b><i>t</i><b>Bu</b>_<b>8</b> nanographene acting as the emitter. This nanographene contains 60 <i>sp</i>² carbon atoms and <i>tert</i>-butyl solubilizing group on the periphery; it was synthesized via the bottom-up approach. The <b>C</b>_<b>60</b><b>-</b><i>t</i><b>Bu</b>_<b>8</b> was fully characterized, and it was incorporated into the emissive layer of a benchmark OLED stack (ITO/PEDOT:PSS/NG-containing active layer/BCP/TmPyPB/LiF/Al). The OLED devices containing the <b>C</b>_<b>60</b><b>-</b><i>t</i><b>Bu</b>_<b>8</b> exhibited current and power efficiencies (CE and PE) of 2.27 cd·A^–1, 0.28 lm·W^–1 and luminance of 164 cd·m^–2. The performance remains modest in comparison to state-of-the-art OLEDs, but it outperforms previous attempts to utilize nanographenes as active materials for fluorescent OLEDs. Following the initial results, we also tested two other NGs (<b>C</b>_<b>78</b><b>-</b><i>t</i><b>Bu</b>_<b>6</b> and <b>C</b>_<b>96</b><b>-</b><i>t</i><b>Bu</b>_<b>8</b>), which contain 78 and 96 <i>sp</i>² carbon atoms as fluorescent emitters in OLEDs. The objective was to fine-tune the electroluminescence to yellow-orange and red light.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"8 16","pages":"8473–8479 8473–8479"},"PeriodicalIF":5.3,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143867291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioactive Gold Nanoparticles Synthesized by Lactobacillus acidophilus for Catalytic and Antibacterial Applications","authors":"Saima Hameed,&nbsp;Ruiyun Zhou,&nbsp;Sumaira Sharif,&nbsp;Bhushan Dharmadhikari,&nbsp;Peiqiao Wu,&nbsp;Prabir Patra,&nbsp;Lijuan Xie* and Yibin Ying,&nbsp;","doi":"10.1021/acsanm.5c0007310.1021/acsanm.5c00073","DOIUrl":"https://doi.org/10.1021/acsanm.5c00073https://doi.org/10.1021/acsanm.5c00073","url":null,"abstract":"<p >The biological synthesis of nanoparticles can potentially widen the possibilities for their applications by avoiding the involvement of hazardous chemicals. In this study, we used<i>Lactobacillus acidophilus</i>in an environmentally friendly way to produce gold nanoparticles (AuNPs) via extracellular means, which were confirmed by various physicochemical techniques. The surface-bound proteins and major carbon functional groups (C–H, C–C, and C–N) formed and stabilized the AuNPs. These AuNPs exhibited strong catalytic activity by reducing various dyes, including methylene blue, Congo red, methyl orange, and malachite green. Methylene blue and Congo red were reduced within 5 min, while methyl orange was reduced within 10 min, and malachite green showed a complete reduction reaction in 3 min in the presence of AuNPs with respective catalytic performance of 64.4, 5, 49.4, and 26.8% in the first cycle. These AuNPs were proven to be a moderate antioxidant agent by oxidizing 1, 1-diphenyl-2-picrylhydrazyl compound within 40 min. A thin layer of AuNPs on the disposable carbon electrode showed their electrochemical sensitivity, which can provide an excellent platform for gold nanoparticle-based biosensors. The bactericidal effect of these AuNPs was tested against<i>Escherichia coli</i>and<i>Listeria monocytogenes</i>, and their antibacterial properties were exposed by compromising cellular integrity, shown as damaged membranes and demolished cells. The distinguishable antibacterial effect of AuNPs was detected using metamaterial-based terahertz spectroscopy in our study, demonstrating its potential for rapid, noninvasive detection of microbial contamination on eggshells and crab shells, ensuring improved food safety and quality control. The synthesis approach used in this study is environmentally friendly and can produce biochemically active metal nanoparticles without involving environmental hazards.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"8 16","pages":"7952–7966 7952–7966"},"PeriodicalIF":5.3,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143867292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antibody-Functionalized Plasmonic Biofiber Sensors with Layered Nanomaterials for Sensitive Listeria monocytogenes Detection","authors":"Guiwei Zhang,&nbsp;Ragini Singh,&nbsp;Bingyuan Zhang,&nbsp;Santosh Kumar* and Guoru Li*,&nbsp;","doi":"10.1021/acsanm.5c0072110.1021/acsanm.5c00721","DOIUrl":"https://doi.org/10.1021/acsanm.5c00721https://doi.org/10.1021/acsanm.5c00721","url":null,"abstract":"<p ><i>Listeria monocytogenes</i> (<i>L. monocytogenes</i>) is one of the pathogenic bacteria threatening human health. Upon infection, it causes symptoms such as sepsis and meningitis in immunocompromised individuals. This work introduces a biofiber sensor that utilizes the plasmonic principle for detecting <i>L. monocytogenes</i>. The fiber structure consists of multimode fiber (MMF) and seven-core fiber (SCF). The core-mismatch configuration between MMF and SCF, along with the W-shaped architecture of the seven-core fiber, amplifies the evanescent field on the fiber surface. Gold nanoparticles are affixed to the sensor region’s surface to elicit the plasmonic effect. Additionally, the layered structure of bismuthene and antimonene functionalizes the fiber, improving the biocompatibility and durability of the fiber sensing region. Moreover, the layered nanostructured bismuthene and antimonene provide a high specific surface area, offering additional reference sites for antibody functionalization. To enhance the specificity of the sensor, an anti-<i>Listeria monocytogenes</i> functional fiber is used. The results show that the sensitivity of the sensor is 0.45 nm/log₁₀(CFU/mL), and the detection limit is 0.89 CFU/mL when the concentration of <i>L. monocytogenes</i> is between 10⁰ and 10⁸ CFU/mL. In addition, the actual test performance of the sensor is evaluated by using real samples. The recovery rates of milk, cheese, tomato, and ice-cream range from 133–91.5, 133–67, 133–67, and 100–74.9%, demonstrating its effectiveness in detecting <i>L. monocytogenes</i>.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"8 16","pages":"8250–8259 8250–8259"},"PeriodicalIF":5.3,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143867633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phase Interface Engineering Using Defective 1T/2H-MoSe2 for Electromagnetic Wave Absorption","authors":"Tengfei Wang,&nbsp;Qing Pang,&nbsp;Boyu Liu and Hongyu Wang*,&nbsp;","doi":"10.1021/acsanm.5c0101610.1021/acsanm.5c01016","DOIUrl":"https://doi.org/10.1021/acsanm.5c01016https://doi.org/10.1021/acsanm.5c01016","url":null,"abstract":"<p >In recent years, molybdenum diselenide (MoSe₂) nanomaterials have been proven to be promising electromagnetic wave (EMW) absorbers, attributed to the formation of a heterogeneous interface between the 2H semiconductor phase and the 1T metal phase during its preparation. However, the difficulty in precisely controlling the two-phase ratio and the complexity of the process hinder its further development. In this work, we constructed a simple phase engineering strategy based on the regulation of reducing agent concentration, achieving a regulation of the 1T phase proportion in defective 1T/2H-MoSe₂ nanomaterials (ranging from 67.91 to 41.45%) by accurately adjusting the amount of NaBH₄ added. The findings indicate that the material exhibits excellent microwave absorption performance when the 1T phase proportion reaches 53.55% (1T/2H-MoSe₂-2), demonstrating a minimum reflection loss (RL_min) of −40.0 dB, and the effective absorption bandwidth (EAB) covers 6.08 GHz (11.92–18.0 GHz) when the thickness is 2.6 mm. The enhancement in performance results from a synergistic balance mechanism established by the abundant 1T-2H heterogeneous interface, which induces interfacial polarization loss, along with a moderately enhanced conductive loss in the 1T/2H-MoSe₂-2 nanomaterial. Furthermore, radar cross-section (RCS) simulation results confirm the dramatic dissipation ability of absorbers for EMW in practical applications. This strategy paves the way for designs of interfaces and the control of the performance of absorbing nanomaterials based on transition-metal dichalcogenides (TMDs).</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"8 16","pages":"8376–8384 8376–8384"},"PeriodicalIF":5.3,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143867594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lignin-Bonded Aramid Nanofiber/Graphene Composite Membranes for Tough and Stable Joule Heating","authors":"Zhihao Duan,&nbsp;Hongzhen Cai,&nbsp;Keyan Yang,&nbsp;Jiankang Zhang and Xiangsheng Han*,&nbsp;","doi":"10.1021/acsanm.5c0075010.1021/acsanm.5c00750","DOIUrl":"https://doi.org/10.1021/acsanm.5c00750https://doi.org/10.1021/acsanm.5c00750","url":null,"abstract":"<p >Flexible electric-heating materials (EHMs) with mechanical toughness and stability are in high demand in areas of portable heating elements; however, they are still hard to achieve. Here, strong and tough aramid nanofiber (ANF)/graphene composite membranes were fabricated with the help of interfacial lignin bonding through a noncovalent interaction-triggered “bridging” strategy. The as-prepared membranes (ANF-L<i>_<i>x</i></i>-G<i>_<i>y</i></i>) exhibited a maximum mechanical strength of ∼122.5 MPa, a maximum toughness of ∼377.2 MJ/m³, and also promising stabilities in commonly used solvents. Ascribing to the uniform distribution of graphene, the composite membranes presented enhanced conductivity (∼278 S/m) and demonstrated both high efficiency and stability for Joule heating performance (e.g., reaching ∼165 °C under an input voltage of 20 V within 5 s, eventually stabilizing at ∼200 °C, and remaining stable after 12 h of Joule heating). Besides the Joule heating application under low temperatures (e.g., joint worming below 100 °C), the stability of ANF-L<i>_<i>x</i></i>-G<i>_<i>y</i></i> also endowed them with favorable performances under high temperatures (e.g., deicing beyond 100 °C). Thus, this work paved a feasible way to develop ANF-based membranes that were strong and stable as flexible EHMs.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"8 16","pages":"8241–8249 8241–8249"},"PeriodicalIF":5.3,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143867285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modifying Separators with a Multistrategy-Constructed (ZnCo)3S4–MoS2 Heterostructure for High-Performance Lithium–Sulfur Batteries","authors":"Tingting Zhao,&nbsp;Jin Wang*,&nbsp;Chenghui Du,&nbsp;Wenbin Li,&nbsp;Meiying Zhao,&nbsp;Rong Wang,&nbsp;Ying Xin,&nbsp;Kebin Zhou* and Zhaoliang Zhang*,&nbsp;","doi":"10.1021/acsanm.5c0074710.1021/acsanm.5c00747","DOIUrl":"https://doi.org/10.1021/acsanm.5c00747https://doi.org/10.1021/acsanm.5c00747","url":null,"abstract":"<p >Lithium–sulfur (Li–S) batteries are considered promising candidates for next-generation energy storage systems. Developing high-efficiency catalysts to improve kinetics and inhibit the shuttle effect is a challenging task. In this study, a three-dimensional (3D) (ZnCo)₃S₄–MoS₂ heterostructure was constructed at the nanoscale and used as a decoration for the separator of durable Li–S batteries. Benefiting from the generation of the built-in electric field between 3D (ZnCo)₃S₄ and in situ grown MoS₂ nanosheet, the rapid transport of ions and electrons and excellent polysulfide redox kinetics are observed in the (ZnCo)₃S₄–MoS₂, which results in a smooth ″adsorption–diffusion–conversion″ process of polysulfides. The Zn dopant effectively reduces the work function of Co₃S₄ via an electron transfer from Zn to Co₃S₄, strengthening the built-in electric field. The battery equipped with the (ZnCo)₃S₄–MoS₂ nanomaterial-modified separator delivers a high initial discharge capacity of 1180.5 mAh g^–1 at 1 C conditions and a low attenuation rate of 0.054% after 1000 cycles. In addition, the battery also exhibits good cycling stability at a high sulfur loading of 3 mg·cm^–2, maintaining a capacity of 704.4 mAh g^–1 (84.9% capacity retention) after 200 cycles at 0.1 C. This study provides a promising strategy to design highly efficient catalysts for durable Li–S batteries.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"8 16","pages":"8220–8230 8220–8230"},"PeriodicalIF":5.3,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143867288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhanced Luminescence Properties of ZnS Nanoparticles for LEDs Applications via Doping and Phase Control","authors":"Long Han,&nbsp;Yongwang Cao,&nbsp;Yankun Chen,&nbsp;Lu Tian,&nbsp;Wenhuai Tian* and Zhipeng Li*,&nbsp;","doi":"10.1021/acsanm.5c0110810.1021/acsanm.5c01108","DOIUrl":"https://doi.org/10.1021/acsanm.5c01108https://doi.org/10.1021/acsanm.5c01108","url":null,"abstract":"<p >Cu- and Al-doped ZnS nanoparticles (NPs) were synthesized via a hot-injection method. The results indicate that the addition of Cu initially increases and subsequently decreases the luminescence intensity, reaching a peak at a Cu content of 0.5%. Furthermore, Al doping leads to a significant increase in luminescence intensity, accompanied by a blue-shift of the emission peaks. Additionally, an increase in the concentration of the Cu dopant induces a phase transition of ZnS from cubic to hexagonal at a low temperature. Moreover, a positive correlation is observed between the dopant concentration and the average particle size. The addition of Al results in a significant decrease in the average particle size, which ranges from approximately 3.59 to 4.34 nm. Although the band gap of ZnS is slightly reduced after doping, it remains stable. This study suggests that the addition of Al primarily forms a donor–acceptor pair with Cu, thereby enhancing Cu’s emission. Modulating the doping concentrations of Cu and Al can adjust the emission position while significantly increasing the photoluminescence quantum yield (PL QY) after doping. The highest PL QY is achieved with ZnS:0.5% Cu, 2.0% Al, which is 21.8 times higher than that of the undoped ZnS. This material has the potential to be employed in a variety of applications, including light-emitting diodes, inorganic scintillators, and anticounterfeiting techniques.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"8 16","pages":"8445–8454 8445–8454"},"PeriodicalIF":5.3,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143867353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of Bases on Surface Functionalities of Polydopamine Nanoparticles: Impact on Radical Trapping Properties","authors":"Gabrielle Rey,&nbsp;Trey Fricker and Ali Dhinojwala*,&nbsp;","doi":"10.1021/acsanm.5c0057710.1021/acsanm.5c00577","DOIUrl":"https://doi.org/10.1021/acsanm.5c00577https://doi.org/10.1021/acsanm.5c00577","url":null,"abstract":"<p >Melanin is a biological nanomaterial with a variety of functions, for example, its ability to quench free radicals. Even though the surface chemistry of melanin is important for these properties, this area has remained relatively unexplored. Here, we compare differences in surface properties of polydopamine (PDA, synthetic mimic of natural melanin) nanoparticles synthesized using three different bases commonly reported in the literature. We use a fluorescence assay and X-ray photoelectron spectroscopy (XPS) to characterize the surface functionalities of nanoparticles synthesized using these three bases. Fluorescence measurements reveal that the PDA synthesized using tris and bicine bases had higher concentrations of amine and carbonyl groups compared to PDA synthesized using ammonium hydroxide. XPS measurements confirmed the presence of carbonyl and amine groups. However, this technique was not able to distinguish the differences in surface chemistry that we observed using fluorescence spectroscopy. Using a 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical trap assay, we demonstrated that the PDA nanoparticles synthesized using tris and bicine were more effective in quenching free radicals compared to PDA synthesized using ammonium hydroxide, correlating with a higher fraction of carbonyl groups on the surface of the PDA nanoparticles.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"8 16","pages":"8122–8132 8122–8132"},"PeriodicalIF":5.3,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143867595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanoascorbate Promotes Clearance of Mutant Huntingtin Aggregates via Restoration of Blocked Autophagy","authors":"Nibedita Pradhan*,&nbsp;Santanu Shaw and Nihar Ranjan Jana*,&nbsp;","doi":"10.1021/acsanm.5c0024010.1021/acsanm.5c00240","DOIUrl":"https://doi.org/10.1021/acsanm.5c00240https://doi.org/10.1021/acsanm.5c00240","url":null,"abstract":"<p >Impaired autophagy is a key contributor to aging and a variety of protein aggregation-linked neurodegenerative disorders. In this direction, autophagy modulation is emerging as a therapeutic approach to combat protein aggregation-related neuronal diseases. Herein, we report that nanoascorbate, a biocompatible polymeric nanoform of vitamin C, accelerates the clearance of mutant Huntingtin protein aggregates in HD150Q, the cellular model of Huntington’s disease by restoring blocked autophagy. We have confirmed that nanoascorbate induces autophagic flux in autophagy-compromised Huntington’s model cells bearing mutant Huntingtin aggregates, evident from the altered expression level of the characteristic autophagy marker protein LC3BII and rapid degradation of crucial cargo receptor SQSTM/p62. In addition, blockade of autophagy induction using a potent autophagy inhibitor causes depression/failure of clearance of protein aggregates by nanoascorbate, indicating that nanoascorbate induces autophagy-mediated degradation. Furthermore, nanoascorbate-mediated upregulation of autophagic flux is ROS- and glutathione reductase-dependent. A brief incubation of 3h with a low micromolar concentration of nanoascorbate has shown an average 90% clearance of high-molecular-weight soluble aggregate of neurotoxic mutant Huntingtin protein, within 2 days. Nanoascorbate is faster, and a low micromolar concentration is sufficient compared to a high molar concentration of trehalose, a conventional autophagy inducer, that achieves only an average of 38% degradation after 96 h of prolonged incubation. In general, induced HD150Q cells bearing neurotoxic polyglutamine aggregates are prone to rapid apoptotic death. Nanoascorbate rescues mutant huntingtin aggregate-bearing cells from apoptotic insult which is evident from the lowered expression of cleaved caspase-3 manifolds, after brief incubation with nanoascorbate. In addition, dietary supplementation of nanoascorbate has shown moderate improvement in motor activity, an increase in life span, and suppression of progressive polyQ-induced eye degeneration to some extent in the transgenic <i>Drosophila</i> model of Huntington’s disease. Our findings manifest the remarkable neurotherapeutic potential of the nanoform of ascorbate via autophagy modulation in autophagy-compromised conditions as well as a moderate neuroprotective effect in the transgenic <i>Drosophila</i> model of Huntington’s disease. In addition, the current study emphasizes that modulation of autophagy can be considered as a promising therapeutic approach for proteinopathy-related neurodegenerative diseases.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"8 16","pages":"7974–7988 7974–7988"},"PeriodicalIF":5.3,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143867284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}