Photochemical & Photobiological Sciences最新文献

{"title":"Solvatochromism and cis-trans isomerism in azobenzene-4-sulfonyl chloride.","authors":"İsa Sıdır, Yadigar Gülseven Sıdır, Halil Berber, Rui Fausto","doi":"10.1007/s43630-025-00684-0","DOIUrl":"https://doi.org/10.1007/s43630-025-00684-0","url":null,"abstract":"<p><p>Solvatochromism exhibited by azobenzene-4-sulfonyl chloride (here abbreviated as Azo-SCl) has been investigated in a series of non-polar, polar-aprotic and polar-protic solvents. The UV-vis spectra of Azo-SCl exhibit two long-wavelength bands, observed at 321-330 nm (band-I) and 435-461 nm (band-II), which are ascribed to the π*-π (S₂ ← S₀) and π*-n (S₁ ← S₀) transitions, respectively. The shorter wavelength band indicates a reversal in solvatochromism, from negative to positive solvatochromism, for a solvent with a dielectric constant of 32.66 (which is characteristic of methanol), while the longer wavelength band signposts negative solvatochromism in all range of solvent's dielectric constant investigated, demonstrating different interactions with the solvents in the S₂ and S₁ excited states. Using Catalán and Kamlet-Taft solvation energy models, we found that the shift in the solvatochromic behavior of band-I (S₂ ← S₀) happens because solvent dipolarity/polarizability and hydrogen bonding affect the S₂ state in opposite ways. Dipolarity/polarizability stabilizes the S₂ state compared to the ground state, while hydrogen bonding destabilizes it. In contrast, for S₁, both effects work together to destabilize the excited state. For all studied solvents, UV irradiation (λ ≥ 311 nm; room temperature) was found to lead to fast trans-cis azo photoisomerization. In the absence of light, the photogenerated cis form quickly converts back to the trans form. Interpretation of the experimental data is supported by quantum chemical calculations undertaken within the Density Functional Theory (DFT) framework, including Time Dependent DFT calculations for excited states.</p>","PeriodicalId":98,"journal":{"name":"Photochemical & Photobiological Sciences","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143021327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Curcumin-coated iron oxide nanoparticles for photodynamic therapy of breast cancer.","authors":"Virginia Rezende Ferreira, Aveline Ventura, Marcela Cândido, Juliana Ferreira-Strixino, Leandro Raniero","doi":"10.1007/s43630-025-00682-2","DOIUrl":"https://doi.org/10.1007/s43630-025-00682-2","url":null,"abstract":"<p><p>Breast cancer is the deadliest cancer among women and its treatment using traditional methods leads the patient to experience adverse effects. However, photodynamic therapy (PDT) is a non-invasive therapy modality that works through a photosensitizing agent, which treating activated by a suitable light source, releases reactive oxygen species capable of treating cancer. Furthermore, recent research indicates that combining PDT and nanoparticles can enhance therapeutic effects. In this way, the synthesis of IONPs (iron oxide nanoparticles) was carried out, and their subsequent coating was done with curcumin (IONPs@curcumin) so that they could act as therapeutic agents against breast cancer. Curcumin solubility tests were carried out to achieve the best results, with ethanol as a solvent, in different concentrations of ethanolic curcumin solution, with the optimal outcome observed at a concentration of 1 mM. Subsequently, the stability analysis was conducted by adjusting the pH of the medium, revealing that at pH 10, the IONPs@curcumin exhibited the best stability and dispersion conditions. Then, cytotoxicity tests of IONPs@curcumin were carried out on the MDA-MB-468 triple-negative breast cancer cell line, under experimental conditions without irradiation and subjected to PDT. The results revealed a viability greater than 70%, as it did not exhibit cytotoxicity for cells in the dark. After 1 h of incubation, the PDT associated with IONPs@curcumin showed 32% of cell viability at a concentration of 30 mg/mL.</p>","PeriodicalId":98,"journal":{"name":"Photochemical & Photobiological Sciences","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142996580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cyanine dye-embedded fluorescent film for ratiometric pH measurement.","authors":"Roch Sobczyk, Laurent Galmiche, Cédric Mongin, Meriem Djendli, Isabelle Leray, Rachel Méallet","doi":"10.1007/s43630-025-00681-3","DOIUrl":"https://doi.org/10.1007/s43630-025-00681-3","url":null,"abstract":"<p><p>The precise monitoring of pH is critical in various applications, particularly in biology-related areas. In this work, we report the synthesis and characterization of a novel cyanine-based fluorescent pH sensor with a pK_a around 6. This pH-sensitive dye features a cyanine chromophore coupled to a piperazine moiety, which modulates the protonation equilibrium and thus the optical response. DTF calculation corroborates the changes in the photophysical properties upon protonation. Upon immobilization within a hydrophilic polymer matrix, the resulting fluorescent sensor is exhibited a pK_a around 4.5, facilitating ratiometric pH measurements for acidic media (for instance in food-examples given in milk and fresh yogurt). Importantly, this probe design allowed a less than 5 min response time to pH changes while avoiding cytotoxic effects towards E. coli. The development of such a fluorescent pH indicator is motivated by the growing need for optical monitoring tools capable of providing real-time, non-invasive readouts of pH dynamics in complex media and microfluidic systems.</p>","PeriodicalId":98,"journal":{"name":"Photochemical & Photobiological Sciences","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142996581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Twenty-first century surface UV radiation changes deduced from CMIP6 models. Part I: evolution of major influencing factors.","authors":"A Chatzopoulou, K Tourpali, A F Bais, P Braesicke","doi":"10.1007/s43630-025-00685-z","DOIUrl":"https://doi.org/10.1007/s43630-025-00685-z","url":null,"abstract":"","PeriodicalId":98,"journal":{"name":"Photochemical & Photobiological Sciences","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142996579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unravelling the modes of phototoxicity of NIR absorbing chlorophyll derivative in cancer cells under normoxic and hypoxic conditions.","authors":"Sucharita Chatterjee, Alok Dube, Shovan Kumar Majumder","doi":"10.1007/s43630-024-00680-w","DOIUrl":"https://doi.org/10.1007/s43630-024-00680-w","url":null,"abstract":"<p><p>The efficacy of photodynamic treatment (PDT) against deep-seated tumor is hindered by low penetration depth of light as well as hypoxic conditions which prevails in tumor. To overcome this limitation, Near-infrared (NIR) absorbing photosensitizers have been investigated actively. In the present study we evaluated the PDT efficacy of an NIR absorbing chlorophyll derivative 'Cycloimide Purpurin-18 (CIPp-18)' in Human Breast carcinoma (MCF-7) and cervical adenocarcinoma (Hela) cells under normoxic and hypoxic conditions. PDT with CIPp-18 (2.0 µM, 3 h) and NIR light (700 ± 25 nm, 0.36-1.4 J /cm²) induced potent phototoxicity in both the cell lines. Under hypoxic conditions, PDT induced ~ 32% and 42% phototoxicity at LD₅₀ and LD₇₀ light dose, respectively, which corresponds to phototoxic dose under normoxia. CIPp-18 in neat buffer (pH 7.4) showed generation of singlet oxygen (¹O₂) as well as superoxide (O₂^·-) radicals. Studies on ROS generation in cells using fluorescence probes and the effect of mechanistic probes of ¹O₂(Sodium Azide, Histidine, D₂O) and free radicals (DMSO, Mannitol, Cyanocobalamin, SOD-PEG) on phototoxicity show that ¹O₂ plays major role in phototoxicity under normoxia. Whereas, under hypoxic conditions, PDT led to no significant generation of ROS and phototoxicity remained unaffected by cyanocobalamin, a quencher of O₂^·-. Moreover, CIPp-18 showed localization in cell membrane and PDT led to more pronounced loss of membrane permeability in cells under hypoxia than for normoxia. These results demonstrate that CIPp-18 is suitable for PDT of cancer cells under hypoxia and also suggest that phototoxicity under hypoxia is mediated via ROS-independent contact-dependent mechanism.</p>","PeriodicalId":98,"journal":{"name":"Photochemical & Photobiological Sciences","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142996582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"21^st century surface UV radiation changes deduced from CMIP6 models: part I-evolution of major influencing factors.","authors":"A Chatzopoulou, K Tourpali, A F Bais, P Braesicke","doi":"10.1007/s43630-024-00675-7","DOIUrl":"10.1007/s43630-024-00675-7","url":null,"abstract":"&lt;p&gt;&lt;p&gt;For a given solar elevation, the levels of solar ultraviolet radiation at the Earth's surface are determined by the amounts of ozone, aerosols, and clouds, as well as by the reflectivity of the surface. Here, we study the evolution of these factors for three selected decades in the period 1950-2100 using results from simulations with Earth-System models (ESMs) participating in the 6&lt;sup&gt;th&lt;/sup&gt; phase of the Coupled Model Intercomparison Project (CMIP6). The simulations for the future are based on three Shared Socioeconomic Pathways: SSP1-2.6, SSP3-7.0, and SSP5-8.5. The models were grouped according to whether they use prescribed ozone fields or interactive chemistry schemes for ozone, revealing significant differences in the absolute levels and variability of total ozone column between the two groups of models. From mid-twenty-first century onward, the ozone recovery is evident in both groups under SSP3-7.0 and SSP5-8.5, but not under SSP1-2.6. The changes in the aerosol optical depth show distinct geographical patterns that are related to their sources, either natural (i.e., dust, biomass burning) or anthropogenic (industrial activities). The aerosols are generally more abundant in 1990-2000 compared to 1950-1960, particularly over regions with industrial activity, with a reversal of this pattern in 2090-2100. Most of these patterns are present in all three pathways, but with different signs compared to 1990-2000 in some regions (i.e., Europe, North America). Over areas with strong natural sources, the aerosol optical depth (AOD) in 2090-2100 increases further under all pathways. The changes in surface reflectivity are important mainly at the end of the twenty-first century and occur predominantly at the high and polar latitudes of both hemispheres, with reductions relative to 1950-1960 of up to 45% due to sea ice retreat. The alterations in the attenuation of shortwave solar radiation by changing cloudiness (expressed in the form of the cloud modification factor, CMF) are more evident at high latitudes, with decreases in 2090-2100 over the Arctic ranging from -5% (SSP1-2.6) to -13% (SSP5-8.5) and smaller decreases of up to -5% in the vicinity of the Antarctic coast. The simulations of ozone, aerosols, surface reflectivity, and clouds for the recent past (2003-2012) were compared to the Copernicus Atmosphere Monitoring Service (CAMS) reanalysis data, showing for total ozone better agreement to models with interactive ozone chemistry. The model-derived AOD shows significant differences from CAMS in various regions worldwide, with up to 0.2 higher values across the northern hemisphere. Finally, the comparisons for surface reflectivity and cloud effects οn this decadal scale reveal a general agreement between models and observations over most of the globe. Thus, we conclude that the projected changes have a good basis in the recent past, suggesting they are realistic estimates of how factors influencing solar ultraviolet radiation may diffe","PeriodicalId":98,"journal":{"name":"Photochemical & Photobiological Sciences","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142930005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Balance between photoreduction efficiency, cofactor affinity, and allosteric coupling of halogenase flavoenzymes.","authors":"Niklas Diepold, Friederike Reese, Tina Prior, Christian Schnepel, Norbert Sewald, Tilman Kottke","doi":"10.1007/s43630-024-00670-y","DOIUrl":"https://doi.org/10.1007/s43630-024-00670-y","url":null,"abstract":"<p><p>Flavin-dependent halogenases (FDHs) are promising candidates for the sustainable production of halogenated organic molecules by biocatalysis. FDHs require only oxygen, halide and a fully reduced flavin adenine dinucleotide (FADH^-) cofactor to generate the reactive HOX that diffuses 10 Å to the substrate binding pocket and enables regioselective oxidative halogenation. A key challenge for the application of FDHs is the regeneration of the FADH^-. In vitro, FADH^- can be regenerated by photoreduction of the oxidized FAD inside the protein using blue light, turning the halogenase into an inefficient artificial photoenzyme. We aimed to improve the photochemical properties of the tryptophan 5-halogenase PyrH from Streptomyces rugosporus by structure-guided mutagenesis. W279 and W281 of the conserved WxWxIP-motif close to FAD were exchanged against phenylalanine. Time-resolved UV-vis spectroscopy showed that the W281F exchange indeed increased the quantum yield of the one- and two-electron reduction, respectively. The cofactor binding affinity decreased slightly with dissociation constants rising from 31 to 74 μM, as examined by fluorescence anisotropy. FTIR difference spectroscopy demonstrated that the allosteric coupling between the FAD and substrate binding sites was mostly preserved. In contrast, the double mutant did not improve the yield further, while negatively affecting binding affinity and structural coupling. The distal W279F exchange was less effective in all parameters. Photoreductions were additionally delayed by a reversible inactive conformation. We conclude that there is a delicate balance to be considered for screening of FDHs for biocatalysis. Variant PyrH-W281F was found to be the most promising candidate for the application as artificial photoenzyme.</p>","PeriodicalId":98,"journal":{"name":"Photochemical & Photobiological Sciences","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142908831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relaxation process of photoexcited berberine via aggregation and dissociation state-dependent intramolecular electron transfer.","authors":"Kazutaka Hirakawa, Toji Matsuura, Yoshinobu Nishimura, Hakan Mori, Shinsuke Takagi","doi":"10.1007/s43630-024-00673-9","DOIUrl":"https://doi.org/10.1007/s43630-024-00673-9","url":null,"abstract":"<p><p>The fluorescence quantum yield of berberine in aqueous solution is significantly smaller than those of organic solution. The time profile of fluorescence intensity of berberine was analyzed by a bi-exponential function, showing that two kinds of states of berberine exist in the solutions. The observed fluorescence lifetime of shorter lifetime species of berberine in water (0.08 ns) was markedly smaller than those of organic solvents and the relative amplitude of the shorter lifetime was dominated in the aqueous solution. Thus, this shorter lifetime can be explained by the deactivation via intramolecular electron transfer. These two states of berberine were independent of pH. The enthalpy and entropy changes between these two states were - 23.2 kJ mol^-1 and - 90 J K^-1 mol^-1, supporting the aggregation of berberine. In the aggregation state, an electrostatic interaction between cationic berberine and chloride ion decreases the electron accepting ability of the isoquinoline moiety of berberine, resulting in the suppression of intramolecular electron transfer. Furthermore, in the presence of clay, the interaction between berberine and clay increased the fluorescence intensity of berberine and its lifetime, showing that the negative charge of clay suppresses the intramolecular electron transfer. Since the electron transfer quenching of the photo-excited berberine is advantageous for suppressing the phototoxic effect of berberine, the inhibition of berberine aggregation is an important process for the phototoxicity prevention.</p>","PeriodicalId":98,"journal":{"name":"Photochemical & Photobiological Sciences","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142890601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Twenty-first century surface UV radiation changes deduced from CMIP6 models. Part II: effects on UV index and plant growth weighted irradiance.","authors":"Anthi Chatzopoulou, K Tourpali, A F Bais, P Braesicke","doi":"10.1007/s43630-024-00676-6","DOIUrl":"https://doi.org/10.1007/s43630-024-00676-6","url":null,"abstract":"<p><p>This paper investigates the evolution of changes in surface ultraviolet (UV) radiation globally, emphasizing the significant impacts of key factors influencing its variability, i.e., total column ozone, aerosols, clouds, and surface reflectivity. Simulations of UV radiation were performed by the UVSPEC radiative transfer model and span from the mid-twentieth century to the end of the twenty-first century. Input data were derived from eleven Earth System Models that participated in the 6th Phase of the Coupled Model Intercomparison Project (CMIP6). The UV Index (UVI) simulations for the late twentieth century indicate an increase in UVI levels relative to the 1950s in the Southern Hemisphere's mid and high latitudes, attributed to ozone depletion, and decreases in southeastern Asia due to increases in aerosols. Projections of changes in UVI for the last decade of the twenty-first century were derived for three Shared Socioeconomic Pathways (SSPs): SSP1-2.6, SSP3-7.0, and SSP5-8.5. Under SSP1-2.6, the scenario with the lowest greenhouse gas (GHG) and aerosol emissions, UVI is projected to increase relative to the 1950s by up to 20% in Europe and North America and to decrease by as much as - 10% over tropical and polar regions. Under SSP3-7.0 and SSP5-8.5, scenarios with higher GHG and aerosol emissions, UVI changes are generally negative globally due to ozone recovery and increases in aerosol optical depth, while localized positive changes are found over Central and South America, Europe, Africa, and the Pacific and Indian Oceans. The changes in the biologically effective solar irradiance for plant growth exhibit similar geographical patterns to UVI with slight differences, due to weaker sensitivity to changes in ozone.</p>","PeriodicalId":98,"journal":{"name":"Photochemical & Photobiological Sciences","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142884855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Photophysical behavior of meso-N-butylcarbazole-substituted BODIPY in different nano-scale organized media.","authors":"E Anjana, Iti Gupta, Ashok Kumar Mishra","doi":"10.1007/s43630-024-00678-4","DOIUrl":"https://doi.org/10.1007/s43630-024-00678-4","url":null,"abstract":"<p><p>The present work focuses on the photophysical behavior of meso-N-butylcarbazole-substituted BODIPY (CBZ-BDP) in different organized media towards exploring the possible use of the dye as a molecular sensor and imaging agent. The molecule shows an appreciable change in absorption and emission spectra at 75% water-acetonitrile mixture compared to pure acetonitrile. In water-acetonitrile mixture, it displays aggregate-induced emission (AIE) bands. New emission peaks are observed at 560 nm and 630 nm, corresponding to LE (locally excited) and ICT (intramolecular charge transfer) states of CBZ-BDP aggregates. The fluorescence anisotropy studies of CBZ-BDP in glycerol medium show its better sensitivity towards the microenvironment. CBZ-BDP was used to probe various microheterogeneous systems like bile salts, pluronics, and lipid bilayer systems in aqueous medium. The dye displays sensitive variation in emission intensity and fluorescence anisotropy in sodium cholate (NaC) bile salt in aqueous medium as a function of the bile salt concentration. The molecule detects the temperature-induced phase transitions in pluronic P123 and F127, as well as 1,2-dimyristoylphosphatidylcholine (DMPC) and 1,2-dipalmitoylphosphatidylcholine (DPPC) lipid bilayer systems in aqueous medium. These studies strongly suggest that CBZ-BDP can be used as an efficient fluorescent probe in sensing the micro-environmental changes in bile salts, pluronics, and lipid bilayers in aqueous medium. The imaging studies of CBZ-BDP-embedded Giant Unilamellar Vesicles (GUVs) were carried out. The molecule stains the lipid bilayers and displays bright-green fluorescent images, suggesting its potential in lipid bilayer imaging.</p>","PeriodicalId":98,"journal":{"name":"Photochemical & Photobiological Sciences","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142870584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}