Photochemical & Photobiological Sciences最新文献

Non-communicable diseases: can implementation research change the game for policy and practice? 非传染性疾病：实施研究能否改变政策和实践的游戏规则？

IF 2.7 3区化学

Photochemical & Photobiological Sciences Pub Date : 2024-11-16 Epub Date: 2024-07-01 DOI: 10.1016/S0140-6736(24)01309-6

Kumanan Rasanathan, Phyllis Dako-Gyeke, Wanrudee Isaranuwatchai, Yodi Mahendradhata, Morven Roberts, Giulia Loffreda, Sarah Rylance, Bente Mikkelsen

引用次数: 0

Dimly illuminated nights alter behavior and negatively affect fat metabolism in adult male zebra finches. 昏暗的夜晚会改变成年雄性斑马雀的行为，并对其脂肪代谢产生负面影响。

IF 2.7 3区化学

Photochemical & Photobiological Sciences Pub Date : 2024-11-15 DOI: 10.1007/s43630-024-00659-7

Mayank Kumar, Ashwani Kumar, Vatsala Tripathi, Abhilash Prabhat, Sanjay Kumar Bhardwaj

{"title":"Dimly illuminated nights alter behavior and negatively affect fat metabolism in adult male zebra finches.","authors":"Mayank Kumar, Ashwani Kumar, Vatsala Tripathi, Abhilash Prabhat, Sanjay Kumar Bhardwaj","doi":"10.1007/s43630-024-00659-7","DOIUrl":"https://doi.org/10.1007/s43630-024-00659-7","url":null,"abstract":"This experiment investigated the effects of an ecologically relevant level of dim light at night (dLAN) on behavior, physiology and fat metabolism associated gene expressions in central and peripheral tissues of adult male zebra finches that were hatched and raised in 12:12 h LD cycle (Ev, day = 150 ± 5 lx; Ev, night = 0 lx) at 22 ± 2 °C temperature. Half of the birds (n = 8) were maintained on LD cycle and temperature, as before (control), to the other half of birds the 12 h dark period was dimly illuminated at ~ 5 lx (dim light at night, dLAN; Ev, day = 150 ± 5 lx; Ev, night = ~ 5 lx) for 6 weeks. The exposure to dLAN altered the 24 h activity and feeding patterns with enhanced activity and feeding at night. Birds under dLAN fattened and gained weight, and had higher night glucose levels. Concurrently, a negative effect of dLAN was found on mRNA expression of ppar-alpha and cd36 genes involved in the fat metabolism in the hypothalamus, intestine, liver and muscle. These results suggest a more global effect of dLAN exposure on obesity and perhaps long-term health risks due to obesity-related complications to diurnal animals including humans inhabiting an urbanized environment.","PeriodicalId":98,"journal":{"name":"Photochemical & Photobiological Sciences","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142637946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

OLUFF: a novel set of ground and excited state force field parameters of the emitting oxyluciferin species. OLUFF：一套新的发射型氧荧光素的基态和激发态力场参数。

IF 2.7 3区化学

Photochemical & Photobiological Sciences Pub Date : 2024-11-13 DOI: 10.1007/s43630-024-00654-y

Henar Mateo-delaFuente, Juan J Nogueira

引用次数: 0

Priorities for sickle cell disease global research and implementation. 镰状细胞病全球研究和实施的优先事项。

IF 98.4 3区化学

Photochemical & Photobiological Sciences Pub Date : 2024-11-09 Epub Date: 2024-07-10 DOI: 10.1016/S0140-6736(24)01400-4

Ambroise Wonkam, Nchangwi Syntia Munung, Aldiouma Guindo, Obiageli Nnodu

引用次数: 0

Addressing global gun violence: a Lancet Commission on Global Gun Violence and Health. 应对全球枪支暴力：柳叶刀全球枪支暴力与健康委员会。

IF 98.4 3区化学

Photochemical & Photobiological Sciences Pub Date : 2024-11-09 Epub Date: 2024-09-03 DOI: 10.1016/S0140-6736(24)01697-0

Adnan A Hyder, Lorena Barberia

引用次数: 0

Investigation of the ability of 3-((4-chloro-6-methyl pyrimidin-2-yl)amino) isobenzofuran-1(3H)-one to bind to double-stranded deoxyribonucleic acid. 研究 3-((4-氯-6-甲基嘧啶-2-基)氨基)异苯并呋喃-1(3H)-酮与双链脱氧核糖核酸的结合能力。

IF 2.7 3区化学

Photochemical & Photobiological Sciences Pub Date : 2024-11-01 Epub Date: 2024-11-10 DOI: 10.1007/s43630-024-00655-x

Pelin Şenel, Abdullah Al Faysal, Zeynep Yilmaz, Taner Erdoğan, Mustafa Odabaşoğlu, Ayşegül Gölcü

{"title":"Investigation of the ability of 3-((4-chloro-6-methyl pyrimidin-2-yl)amino) isobenzofuran-1(3H)-one to bind to double-stranded deoxyribonucleic acid.","authors":"Pelin Şenel, Abdullah Al Faysal, Zeynep Yilmaz, Taner Erdoğan, Mustafa Odabaşoğlu, Ayşegül Gölcü","doi":"10.1007/s43630-024-00655-x","DOIUrl":"10.1007/s43630-024-00655-x","url":null,"abstract":"Phthalides represent a notable category of secondary metabolites that are prevalent in various plant species, certain fungi, and liverworts. The significant pharmacological properties of these compounds have led to the synthesis of a novel phthalide derivative. The current study focuses on investigating the binding interactions of a newly synthesized 3-substituted phthalide derivative, specifically 3-((4-chloro-6-methyl pyrimidine-2-yl)amino) isobenzofuran-1(3H)-one (Z11), with double-stranded deoxyribonucleic acid (dsDNA). Research in the pharmaceutical and biological fields aimed at developing more potent DNA-binding agents must take into account the mechanisms by which these newly synthesized compounds interact with DNA. This investigation seeks to explore the binding dynamics between dsDNA and our compound through a variety of analytical techniques, such as electrochemistry, UV spectroscopy, fluorescence spectroscopy, and thermal denaturation. The binding constant (Kb) of Z11 with DNA was determined using both spectroscopic and voltammetric approaches. The research revealed that Z11 employs a groove binding mechanism to associate with dsDNA. To further explore the interactions between Z11 and dsDNA, the study utilized density functional theory (DFT) calculations, molecular docking, and molecular dynamics simulations. These analyses aimed to ascertain the potential for a stable complex formation between Z11 and dsDNA. The results indicate that Z11 is situated within the minor groove of the dsDNA, demonstrating the ability to establish a stable complex. Furthermore, the findings imply that both π-alkyl interactions and hydrogen bonding play significant roles in the stabilization of this complex.","PeriodicalId":98,"journal":{"name":"Photochemical & Photobiological Sciences","volume":" ","pages":"2107-2121"},"PeriodicalIF":2.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142612329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment of therapeutic response to photodynamic therapy with the Zn-Phthalocyanine RLP068/Cl versus topical Clindamycin in patients affected by Hidradenitis Suppurativa: a comparative clinical pilot study. 评估酞菁锌 RLP068/Cl 光动力疗法与局部使用克林霉素对湿疹患者的治疗反应：一项比较临床试验研究。

IF 2.7 3区化学

Photochemical & Photobiological Sciences Pub Date : 2024-11-01 Epub Date: 2024-11-11 DOI: 10.1007/s43630-024-00656-w

E Rosi, F Prignano, S Viola, M Venturini, N Pimpinelli, P Calzavara-Pinton

{"title":"Assessment of therapeutic response to photodynamic therapy with the Zn-Phthalocyanine RLP068/Cl versus topical Clindamycin in patients affected by Hidradenitis Suppurativa: a comparative clinical pilot study.","authors":"E Rosi, F Prignano, S Viola, M Venturini, N Pimpinelli, P Calzavara-Pinton","doi":"10.1007/s43630-024-00656-w","DOIUrl":"10.1007/s43630-024-00656-w","url":null,"abstract":"Hidradenitis suppurativa is a chronic skin disorder characterized by painful inflammatory nodules and abscesses, significantly impacting patients' quality of life. Current treatment strategies, including topical antibiotics, often yield limited efficacy and pose risks of antibiotic resistance. Photodynamic therapy has emerged as a potential option, with RLP068/Cl (ELKOFAST®, non-sterile formulation) showing promising efficacy due to its broad-spectrum bactericidal activity. We conducted a pilot study assessing the therapeutic response to photodynamic therapy with RLP068/Cl versus topical clindamycin gel in patients affected by hidradenitis suppurativa of Hurley score I, II, and III. Results revealed higher efficacy of photodynamic therapy in combination with RLP068/Cl, particularly in mild cases. Its efficacy remains reliable even in more severe cases when combined with adalimumab. The observed faster lesion improvement and pain relief were ascribed to the bactericidal effects of RLP068/Cl against Gram+ and Gram- bacteria. Furthermore, photoactivated RLP068/Cl was well tolerated with no adverse events reported. Therefore, photodynamic therapy following RLP068/Cl application represents a novel therapeutic option for hidradenitis suppurativa with potential implications for antibiotic stewardship in dermatology.","PeriodicalId":98,"journal":{"name":"Photochemical & Photobiological Sciences","volume":" ","pages":"2123-2132"},"PeriodicalIF":2.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142612303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Different metal-doped NiO nanoparticles for sunlight-mediated degradation of low-density polyethylene microplastic films. 不同金属掺杂的氧化镍纳米粒子在阳光介导下降解低密度聚乙烯微塑料薄膜。

IF 2.7 3区化学

Photochemical & Photobiological Sciences Pub Date : 2024-11-01 Epub Date: 2024-11-09 DOI: 10.1007/s43630-024-00653-z

Jameel Mohammed Musthafa, Badal Kumar Mandal

{"title":"Different metal-doped NiO nanoparticles for sunlight-mediated degradation of low-density polyethylene microplastic films.","authors":"Jameel Mohammed Musthafa, Badal Kumar Mandal","doi":"10.1007/s43630-024-00653-z","DOIUrl":"10.1007/s43630-024-00653-z","url":null,"abstract":"Due to the widespread use and incorrect handling of plastics, we need to find a practical and effective way to eliminate plastic waste from the environment. Different metal-doped nickel oxide (DMD-NiO) nanoparticles (NPs) were synthesized using a sol-gel technique and were used to degrade low-density polyethylene (LDPE) microplastic (MP) films when exposed to sunlight. The optical and structural properties of sol-gel method synthesized materials were investigated using a variety of characterization methods (Fourier transform infrared (FT-IR), UV-vis diffuse reflectance spectroscopy (UV-vis DRS), X-ray diffractometer (XRD) analysis, X-ray photoelectron spectroscopy (XPS), high-resolution transmission electron microscopy (HR-TEM), scanning electron microscopy (SEM) with energy dispersive X-ray (EDX) analysis, and thermogravimetric analysis (TGA). Degradation study results suggest that the photocatalytic activity of DMD-NiO-LDPE nanocomposites (NCs) films was greater than that of pure LDPE and undoped NiO-LDPE films. Because of their increased optical absorption and efficient suppression of photo-produced charge carriers' recombination, the DMD-NiO NPs showed higher photocatalytic degradation of LDPE films. Thus, LDPE films with 2% wt Fe-NiO (iron-doped nickel oxide) nanomaterials showed a degradation of around 38.16% among DMD-NiO-LDPE NCs films under visible light over a short period of 30 days (240 h). The formation of carbonyl groups in the degradation product of LDPE was confirmed by Fourier transform infrared (FT-IR) analysis. When compared to the original LDPE film, the Fe-NiO-LDPE NCs films showed a significant decrease in crystallinity and carbonyl indexes, as much as 8.4% lower. The current project proposes the development of eco-friendly photocatalysts using a sol-gel technique for combating MP pollution in the environment.","PeriodicalId":98,"journal":{"name":"Photochemical & Photobiological Sciences","volume":" ","pages":"2091-2105"},"PeriodicalIF":2.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142612328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Changing the culture of blood culture. 改变血液文化。

IF 98.4 3区化学

Photochemical & Photobiological Sciences Pub Date : 2024-10-19 Epub Date: 2024-09-20 DOI: 10.1016/S0140-6736(24)01942-1

Sally Davies, Richard A Marfuggi, Rick A Bright, Steve Brozak, Michael Osterholm

引用次数: 0

More mpox data are needed to better respond to the public health emergency of international concern. 需要更多的 mpox 数据，以更好地应对这一国际关注的公共卫生紧急事件。

IF 98.4 3区化学

Photochemical & Photobiological Sciences Pub Date : 2024-10-12 Epub Date: 2024-09-26 DOI: 10.1016/S0140-6736(24)02070-1

Liang Wang, George F Gao

引用次数: 0