农林科学最新文献

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AI-assisted post-mortem classification of vehicle trauma in free-roaming cats using transformer-based large language models. 使用基于变压器的大型语言模型对自由漫游猫的车辆创伤进行人工智能辅助死后分类。
IF 3.9 2区 农林科学
Veterinary Quarterly Pub Date : 2026-12-31 Epub Date: 2026-08-03 DOI: 10.1080/01652176.2026.2705200
Hyunji Jo, Ji-Su Baek, Donghee Lee, Ah-Young Kim, Kyunghyun Lee, Bok-Kyung Ku, Adam W Stern, Jong Hyuk Kim
{"title":"AI-assisted post-mortem classification of vehicle trauma in free-roaming cats using transformer-based large language models.","authors":"Hyunji Jo, Ji-Su Baek, Donghee Lee, Ah-Young Kim, Kyunghyun Lee, Bok-Kyung Ku, Adam W Stern, Jong Hyuk Kim","doi":"10.1080/01652176.2026.2705200","DOIUrl":"10.1080/01652176.2026.2705200","url":null,"abstract":"<p><p>Veterinary forensic science is a specialized discipline that investigates non-natural animal deaths and injuries. Determining the cause of death in free-roaming cats often presents challenges due to underdeveloped pattern recognition methods and the intricate interplay of events and contributing factors. The integration of natural language processing into forensic investigations may offer potential for the computerized automation of document analysis, with the goal of supporting investigational decision-making. The objective of this study was to develop an AI framework leveraging a transformer-based large language model (LLM) to classify veterinary forensic autopsy reports derived from 271 feline autopsies and to identify the causes of death. We first identified discriminative lexical patterns between vehicular trauma (VT; <i>n</i> = 111) and non-VT cases (<i>n</i> = 160) using Term Frequency-Inverse Document Frequency analysis. The best-performing model, based on Clinical-Longformer, achieved an accuracy of 0.945, precision of 0.885, recall of 1.000, F1 score of 0.939, and AUC-ROC of 0.950. Model interpretability using Integrated Gradients revealed that VT cases were characterized by terms associated with traumatic physical injuries, whereas non-VT cases exhibited a broader range of diagnostic descriptions. These findings demonstrate the feasibility of applying LLMs to veterinary forensic pathological texts and underscore the importance of domain-specific token interpretation for model explainability.</p>","PeriodicalId":51207,"journal":{"name":"Veterinary Quarterly","volume":"46 1","pages":"2705200"},"PeriodicalIF":3.9,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13435293/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148664953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Canine brain imaging with a new low-field portable (0.05 T) MRI scanner: a pilot in vivo comparison to conventional 1.5 T. 犬脑成像与新型低场便携式(0.05 T) MRI扫描仪:与常规1.5 T的试验对比。
IF 3.9 2区 农林科学
Veterinary Quarterly Pub Date : 2026-12-31 Epub Date: 2026-07-14 DOI: 10.1080/01652176.2026.2696026
Elisabeth Maria Burgers, Samantha Miles, Ruben van den Broek, Chloé Najac, Beatrice Lena, Thomas O'Reilly, Andrew Webb, Stefanie Veraa
{"title":"Canine brain imaging with a new low-field portable (0.05 T) MRI scanner: a pilot <i>in vivo</i> comparison to conventional 1.5 T.","authors":"Elisabeth Maria Burgers, Samantha Miles, Ruben van den Broek, Chloé Najac, Beatrice Lena, Thomas O'Reilly, Andrew Webb, Stefanie Veraa","doi":"10.1080/01652176.2026.2696026","DOIUrl":"10.1080/01652176.2026.2696026","url":null,"abstract":"<p><p>Prohibitive costs associated with high-field MRI systems have resulted in reduced access in resource-limited areas with consequential healthcare inequities. This has renewed interest in purposefully designed low-field (LF) systems that, despite inherently lower signal-to-noise ratios, have advantages in terms of cost, portability, and accessibility. This pilot study successfully translated a previously developed LF (0.05 T) MRI canine cadaver brain protocol for <i>in vivo</i> application and compared the acquired images with paired 1.5 T images from 21 different canine patients. The visibility of 15 anatomic features was ordinarily scored (scale 1-3) on transverse T1-weighted post-contrast (21/21 patients) and T2-weighted (17/21 patients) sequences. Lateral ventricles were easily visualized (89.3%-100% scored 3/3) across all sequence‒system combinations, with T2-weighted sequences also providing good identification of the mesencephalic aqueduct (56.3%-100%), fourth ventricle (77.1%-100%), and thalamus (68.8%-100%). Absolute visual grading characteristics (VGC) analysis confirmed comparable performance of the LF system to the 1.5 T MRI for these features, a particularly relevant finding given the system's originally intended application for pediatric hydrocephalus neuroimaging in resource-limited areas. This study represents the first <i>in vivo</i> usage and evaluation of a 0.05 T MRI in a clinical veterinary context.</p>","PeriodicalId":51207,"journal":{"name":"Veterinary Quarterly","volume":"46 1","pages":"2696026"},"PeriodicalIF":3.9,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13371494/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148438286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Structural characterization of PAMK and its protective effect against thymic necroptosis in goslings. PAMK的结构特征及其对雏鹅胸腺坏死的保护作用。
IF 3.9 2区 农林科学
Veterinary Quarterly Pub Date : 2026-12-31 Epub Date: 2026-09-01 DOI: 10.1080/01652176.2026.2695104
Wanyan Li, Baili Lu, Xiangying Zhou, Shirou Pan, Junhao Wei, Bingxin Li, Nan Cao, Yunmao Huang, Wenjun Liu, Xinliang Fu, Yunbo Tian, Danning Xu
{"title":"Structural characterization of PAMK and its protective effect against thymic necroptosis in goslings.","authors":"Wanyan Li, Baili Lu, Xiangying Zhou, Shirou Pan, Junhao Wei, Bingxin Li, Nan Cao, Yunmao Huang, Wenjun Liu, Xinliang Fu, Yunbo Tian, Danning Xu","doi":"10.1080/01652176.2026.2695104","DOIUrl":"10.1080/01652176.2026.2695104","url":null,"abstract":"<p><p>PAMK are heterogeneous glycans with immunomodulatory potential, but their structural basis and mechanisms in regulating thymic injury remain unclear. Structural characterization revealed that PAMK is mainly composed of arabinose, galactose, rhamnose, galacturonic acid, and glucose, featuring a dominant backbone consisting of →4)-<i>α</i>-D-GalpA-(1→, →4)-<i>β</i>-D-Galp-(1→, →2)-<i>α</i>-L-Rhap-(1→, and →3,4)-<i>α</i>-D-GalpA-(1→ with highly branched side chains. This complex structure provides the biochemical foundation for its bioactivity. To explore its immunoprotective effects, we established a CTX-induced thymic necroptosis model in goslings. CTX markedly disrupted cytokine profiles and activated necroptosis signaling, accompanied by downregulation of novel-miR-2 and upregulation of TRADD and MLKL. Dietary PAMK supplementation significantly restored cytokine homeostasis and inhibited necroptosis pathway activation. Mechanistically, PAMK upregulated novel-miR-2, which negatively regulated TRADD and MLKL expression, thereby attenuating necroptosis signaling. Overexpression of novel-miR-2 suppressed TRADD/MLKL-mediated necroptosis, whereas its inhibition produced the opposite effect. Furthermore, PAMK mitigated oxidative stress and necroptotic cell death induced by TRADD and MLKL overexpression. Collectively, our findings demonstrate that the defined structural features of PAMK underpin its ability to protect against CTX-induced thymic necroptosis by upregulating novel-miR-2 and suppressing the TRADD/MLKL axis. This work links PAMK's composition to its immunoprotective function and highlights its potential as a safe immunoregulatory agent in poultry.</p>","PeriodicalId":51207,"journal":{"name":"Veterinary Quarterly","volume":"46 1","pages":"2695104"},"PeriodicalIF":3.9,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13537054/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148867718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rethinking dog stress behaviours: contextual and physiological insights from the attachment framework. 重新思考狗的压力行为:来自依恋框架的语境和生理见解。
IF 3.9 2区 农林科学
Veterinary Quarterly Pub Date : 2026-12-31 Epub Date: 2026-08-21 DOI: 10.1080/01652176.2026.2682284
Giacomo Riggio, Carmen Borrelli, Durmus Atilgan, Giulia Russo, Silvana Diverio, Chiara Mariti
{"title":"Rethinking dog stress behaviours: contextual and physiological insights from the attachment framework.","authors":"Giacomo Riggio, Carmen Borrelli, Durmus Atilgan, Giulia Russo, Silvana Diverio, Chiara Mariti","doi":"10.1080/01652176.2026.2682284","DOIUrl":"10.1080/01652176.2026.2682284","url":null,"abstract":"<p><p>While dogs' behavioural indicators of psychological stress are widely used, their function as reliable stress markers remains debated. Using the Strange Situation Procedure (SSP) as a social-stress paradigm, we evaluated contextual correlates of dog behaviours to explore their validity as stress indicators. In 64 dogs, behaviours commonly used as stress markers were video-coded and analysed via GLMMs to investigate differences across test episodes and attachment styles (secure, anxious, avoidant), while salivary cortisol, oxytocin, and rectal temperature provided a physiological framework. Episode had significant effects on shaking (<i>p</i> < 0.05), lip-licking (<i>p</i> < 0.001), paw-lifting (<i>p</i> < 0.001), whining (<i>p</i> < 0.001), head-turning (<i>p</i> < 0.001), sniffing the door (<i>p</i> < 0.001), and locomotion (<i>p</i> < 0.001), while attachment style significantly affected head-turning only (<i>p</i> = 0.004). Our findings suggest that the observed behaviours were not expressed linearly in relation to expected stress levels across the SSP episodes. This lack of linearity, combined with the divergent physiological correlates found across attachment groups-for instance, oxytocin correlated positively with lip-licking in securely attached dogs (<i>p</i> < 0.05), but negatively in anxious ones (<i>p</i> < 0.05) -, suggests that these behaviours do not function as simple stress indicators. Rather, their meaning appears to be contingent upon the individual's internal state and the socio-environmental context. We discuss our results in light of an alternative semiotic interpretative framework.</p>","PeriodicalId":51207,"journal":{"name":"Veterinary Quarterly","volume":"46 1","pages":"2682284"},"PeriodicalIF":3.9,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13501743/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148801318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Monitoring horse behaviour with deep learning models. 用深度学习模型监测马的行为。
IF 3.9 2区 农林科学
Veterinary Quarterly Pub Date : 2026-12-31 Epub Date: 2026-04-28 DOI: 10.1080/01652176.2026.2665442
Claudia Giannone, Chiara Maccario, Emanuela Dalla Costa, Elie Atallah, Marco Bovo
{"title":"Monitoring horse behaviour with deep learning models.","authors":"Claudia Giannone, Chiara Maccario, Emanuela Dalla Costa, Elie Atallah, Marco Bovo","doi":"10.1080/01652176.2026.2665442","DOIUrl":"10.1080/01652176.2026.2665442","url":null,"abstract":"<p><p>Detailed analysis of stabled horse behaviour can reveal accurate information about its well-being. Advances in deep learning now allow these behaviours to be tracked without being invasive through the use of video data. This study evaluated a convolutional neural network for recognising standing, lying, and drinking behaviours in a horse housed in a wooden stall and recorded continuously over 29 consecutive days. Model predictions were compared with manually annotated ground truth data. Standing was detected with high precision (97.5%) and high recall (89.2%). Lying behaviour was classified with high precision (92.8%) but lower recall (63.1%). Activity patterns showed that standing dominated daily time budgets (>85%), lying accounted for 5-10%, and drinking occurred most often between 04:00 pm and 10:00 pm. These results demonstrate that deep learning can classify common equine behaviours from video, supporting its use in automated welfare monitoring. Future evaluations will explore the recognition of less frequent behaviours.</p>","PeriodicalId":51207,"journal":{"name":"Veterinary Quarterly","volume":"46 1","pages":"2665442"},"PeriodicalIF":3.9,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13126938/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147788560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluating machine learning algorithms based on thermal imaging and milk-based parameters to identify subclinical mastitis in dairy cows. 评估基于热成像和牛奶参数的机器学习算法,以识别奶牛的亚临床乳腺炎。
IF 3.9 2区 农林科学
Veterinary Quarterly Pub Date : 2026-12-31 Epub Date: 2026-06-08 DOI: 10.1080/01652176.2026.2685619
Sushil Paudyal, Rajesh Neupane, Bhuwan Shrestha, Hsin-I Chiang, Ashrant Aryal
{"title":"Evaluating machine learning algorithms based on thermal imaging and milk-based parameters to identify subclinical mastitis in dairy cows.","authors":"Sushil Paudyal, Rajesh Neupane, Bhuwan Shrestha, Hsin-I Chiang, Ashrant Aryal","doi":"10.1080/01652176.2026.2685619","DOIUrl":"10.1080/01652176.2026.2685619","url":null,"abstract":"<p><p>The objective was to evaluate the potential of machine learning algorithms utilizing thermal imaging and/or milk-based parameters for the identification of subclinical mastitis(SCM) in dairy cows. Holstein dairy cows (<i>n</i> = 194) were enrolled, and milk samples were collected from each quarter separately (<i>n</i> = 776 quarter-level samples) and analyzed for milk-based parameters. Four images per cow, representing all four quarters, were captured using a handheld infrared camera. Skin temperatures were extracted using Fluke Connect software, yielding 776 images for analysis. SCM was defined at the quarter level as SCC > 200,000 cells/mL, identifying 139 infected and 637 healthy quarters. The data were analyzed to test Random Forest Classifier(RFC), Logistic Regression Classifier, AdaBoost Classifier(ABC), and Naïve Bayes Classifier algorithms. The RFC models using milk features and temperature features achieved accuracy and precision scores of 0.88 and 0.88, respectively, yielding 0.90 AUC values, with high feature importance for milk lactose and SNF. Using only thermal imaging features, the ABC model yielded accuracy and precision of 0.82 and 0.67, respectively, with 0.56 AUC. We conclude that SCM prediction using machine learning algorithms is most promising when combined with thermal images and milk-based parameters. Future studies with larger datasets and refined methods for thermal image capture and analysis are warranted to validate these findings.</p>","PeriodicalId":51207,"journal":{"name":"Veterinary Quarterly","volume":"46 1","pages":"2685619"},"PeriodicalIF":3.9,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13248482/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148206995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Milk extracellular vesicles reveal insulin resistance status in peripartum dairy cows. 乳细胞外囊泡揭示围产期奶牛胰岛素抵抗状况。
IF 3.9 2区 农林科学
Veterinary Quarterly Pub Date : 2026-12-31 Epub Date: 2026-05-01 DOI: 10.1080/01652176.2026.2665485
Madhusha Prasadani, Hanno Jaakson, Priit Karis, Subhashini Muhandiram, Merike Henno, Sirje Kuusik, Katri Ling, Harinda Rajapaksha, Meelis Ots, Aneta Andronowska, Suranga Pradeep Kodithuwakku, Vallo Volke, Alireza Fazeli
{"title":"Milk extracellular vesicles reveal insulin resistance status in peripartum dairy cows.","authors":"Madhusha Prasadani, Hanno Jaakson, Priit Karis, Subhashini Muhandiram, Merike Henno, Sirje Kuusik, Katri Ling, Harinda Rajapaksha, Meelis Ots, Aneta Andronowska, Suranga Pradeep Kodithuwakku, Vallo Volke, Alireza Fazeli","doi":"10.1080/01652176.2026.2665485","DOIUrl":"10.1080/01652176.2026.2665485","url":null,"abstract":"<p><p>The transition from gestation to lactation is a critical period that leads to insulin resistance (IR) in dairy cows. IR detection requires invasive sampling and laborious methods; therefore, novel and non-invasive approaches are essential. Extracellular vesicles (EVs) are nano-sized particles released by cells and are linked to disease pathophysiology. Hence, the present study aimed to explore the potential application of cow milk EVs (MEVs) in detecting IR in dairy cows. An intravenous glucose tolerance test (IVGTT) was performed (<i>n</i> = 12), and the cows were classified as low, moderate, or high IR based on prepartum area under the curve insulin values. MEVs were enriched using double-size exclusion chromatography and physico-chemically characterized. The results revealed that the particle diameter of MEVs was significantly higher (<i>p</i> ≤ 0.05) in the high-IR group compared to other groups. Out of 26 fatty acids (FAs) detected in MEVs, three long-chain FAs differed significantly in abundance (<i>p</i> ≤ 0.05) in high-IR group. Proteomic analysis revealed a correlation of inflammation and the IR-related proteins; Annexin A1 and Rab proteins, to IR severity. Overall, this study identified promising predictors of IR in cows, supporting the development of non-invasive biomarkers for early detection, facilitating improved herd and disease management, and reducing economic losses.</p>","PeriodicalId":51207,"journal":{"name":"Veterinary Quarterly","volume":"46 1","pages":"2665485"},"PeriodicalIF":3.9,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13137739/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147823237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Photodynamic antimicrobial and antineoplastic therapy in veterinary medicine: current status, challenges, and perspectives. 兽医中的光动力抗微生物和抗肿瘤治疗:现状、挑战和前景。
IF 3.9 2区 农林科学
Veterinary Quarterly Pub Date : 2026-12-31 Epub Date: 2026-08-16 DOI: 10.1080/01652176.2026.2713493
Jiaxu Lu, Shuyao Zhu, Aftab Shaukat, Shuhao Bian, Xiaoxuan Shi, Di Zhu, Jingyu Wang, Aoyun Li, Hongyu Dai, Fang Liu, Haiju Dong, Xiangqian Zhang
{"title":"Photodynamic antimicrobial and antineoplastic therapy in veterinary medicine: current status, challenges, and perspectives.","authors":"Jiaxu Lu, Shuyao Zhu, Aftab Shaukat, Shuhao Bian, Xiaoxuan Shi, Di Zhu, Jingyu Wang, Aoyun Li, Hongyu Dai, Fang Liu, Haiju Dong, Xiangqian Zhang","doi":"10.1080/01652176.2026.2713493","DOIUrl":"10.1080/01652176.2026.2713493","url":null,"abstract":"<p><p>Significant causes of morbidity in veterinary medicine are tumourigenic diseases and pathogenic infections, which pose significant threats to animal health. Traditional methods for treating tumours and bacterial infections primarily involve chemotherapy and antibiotic therapy, both of which are associated with drug resistance and adverse effects. Photodynamic therapy (PDT) is gaining increasing interest in veterinary clinical practice because of its distinctive benefits such as spatiotemporal selectivity, low toxicity, fewer negative effects, and reduced risk of drug resistance. This review summarises the fundamental principles of PDT and its applications in combating tumours and microbial infections in veterinary practice involving companion animals, livestock, wildlife, and reptiles. It is worth noting that the existing clinical evidence is limited by very small sample sizes and the absence of comparator groups; however, these studies have provided a preliminary theoretical foundation and technical reference for further clinical development of PDT. Moreover, the opportunities and challenges associated with PDT in veterinary clinical practice are discussed herein.</p>","PeriodicalId":51207,"journal":{"name":"Veterinary Quarterly","volume":"46 1","pages":"2713493"},"PeriodicalIF":3.9,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13482929/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148764909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Discovery of A SLAMF1 Gene Change That Increases Dogs' Risk of Developing Canine Atopic Dermatitis: a Plain Language Summary. 发现一种增加狗患犬特应性皮炎风险的SLAMF1基因变化:简单的语言总结。
IF 3.9 2区 农林科学
Veterinary Quarterly Pub Date : 2026-12-31 Epub Date: 2026-06-09 DOI: 10.1080/01652176.2026.2670342
Oliver P Forman, Jamie Freyer, Abigail Kerr, Julia D Labadie, Debbie J Gow, Janet Alexander
{"title":"Discovery of A <i>SLAMF1</i> Gene Change That Increases Dogs' Risk of Developing Canine Atopic Dermatitis: a Plain Language Summary.","authors":"Oliver P Forman, Jamie Freyer, Abigail Kerr, Julia D Labadie, Debbie J Gow, Janet Alexander","doi":"10.1080/01652176.2026.2670342","DOIUrl":"10.1080/01652176.2026.2670342","url":null,"abstract":"","PeriodicalId":51207,"journal":{"name":"Veterinary Quarterly","volume":"46 1","pages":"2670342"},"PeriodicalIF":3.9,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13255200/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148213191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Vaccine diluent affects expression levels of immune related genes in caecal tonsils of layer chickens vaccinated with live attenuated Salmonella Typhimurium vaccine. 疫苗稀释液对接种鼠伤寒沙门氏菌减毒活疫苗的蛋鸡盲肠扁桃体免疫相关基因表达水平的影响
IF 3.9 2区 农林科学
Veterinary Quarterly Pub Date : 2026-12-31 Epub Date: 2026-07-19 DOI: 10.1080/01652176.2026.2678598
Samiullah Khan, Andrea R McWhorter, Daniel M Andrews, Gregory J Underwood, Kapil K Chousalkar
{"title":"Vaccine diluent affects expression levels of immune related genes in caecal tonsils of layer chickens vaccinated with live attenuated <i>Salmonella</i> Typhimurium vaccine.","authors":"Samiullah Khan, Andrea R McWhorter, Daniel M Andrews, Gregory J Underwood, Kapil K Chousalkar","doi":"10.1080/01652176.2026.2678598","DOIUrl":"10.1080/01652176.2026.2678598","url":null,"abstract":"<p><p>In this study, <i>Salmonella</i> Typhimurium (ST) vaccine diluent effects on caecal tonsils gene regulation in layer chicks were investigated. A live attenuated ST vaccine was reconstituted in Marek's and/or water diluents, chicks vaccinated and caecal tonsils were assessed for global gene expression at days 7 and 14 post-vaccination. Differentially expressed genes (DEGs) involved in the activation of the intestinal immune network for IgA production were upregulated earlier (e.g. day 7 post-vaccination) in the water diluent group, while in the Marek's diluent group, this pathway was enriched by the upregulated DEGs at day 14 post-vaccination. The commonly upregulated biological pathways between the two diluents were cytokine-cytokine receptor interaction, toll-like receptor signaling pathway and cytosolic DNA-sensing pathway. At day 7 post-vaccination, 28.5% and 40.2% of the significantly upregulated genes were unique to Marek's and water diluents, respectively, whereas 31.3% were common between the Marek's and water diluent groups, showing the role of the diluent in priming the vaccine for host immune system modulation. At day 14 post-vaccination, 52.7% and 15.4% of the upregulated DEGs were unique to Marek's and water diluents, respectively. Overall, the data showed that the live attenuated ST vaccine reconstituted in Marek's diluent affected the regulation of immune system-related genes in the caecal tonsils of chicks, with a difference in pattern when water was used as a diluent.</p>","PeriodicalId":51207,"journal":{"name":"Veterinary Quarterly","volume":"46 1","pages":"2678598"},"PeriodicalIF":3.9,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13386580/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148521619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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