Archives of Insect Biochemistry and Physiology最新文献

{"title":"Hitherto Unknown Sexual Morphs and Mating Behavior of Periphyllus allogenes Szelegiewicz (Hemiptera: Aphididae) From South Korea","authors":"Minho Lee,&nbsp;Mariusz Kanturski,&nbsp;Seunghwan Lee","doi":"10.1002/arch.70228","DOIUrl":"10.1002/arch.70228","url":null,"abstract":"<div>\u0000 \u0000 <p><i>Periphyllus allogenes</i> Szelegiewicz, 1981 is an East Asian aphid species recorded from South Korea and Japan. Although the apterous viviparous female was originally described in 1981 and the fundatrix and alate viviparous female were subsequently reported, the sexual morphs have remained unknown. In 2021, oviparous females and males were collected on <i>Acer triflorum</i> during field surveys in South Korea in late autumn. In addition, mating-associated behavior was observed in colonies containing sexual morphs. In this study, we provide the first descriptions and illustrations of these previously unknown morphs, together with biometric measurements, descriptions, ecological photographs, and biological observations. We also document mating-associated behavior, providing new insights into the reproductive biology of the genus <i>Periphyllus</i>. The discovery of the sexual generation confirms that <i>P</i>. <i>allogenes</i> has a holocyclic life cycle.</p></div>","PeriodicalId":8281,"journal":{"name":"Archives of Insect Biochemistry and Physiology","volume":"123 3","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149332166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Life History and Demographic Traits of Parthenogenetic and Bisexual Haemaphysalis longicornis in the Republic of Korea","authors":"Jaeuk Park,&nbsp;Sanghyeon Kim,&nbsp;Jiseok Kim,&nbsp;Seoyul Hwang,&nbsp;Sukmin Yun,&nbsp;Daniel R. Swale,&nbsp;Donghun Kim","doi":"10.1002/arch.70232","DOIUrl":"https://doi.org/10.1002/arch.70232","url":null,"abstract":"<div>\u0000 \u0000 <p>The Asian longhorned tick, <i>Haemaphysalis longicornis</i>, is one of the predominant hard tick species in the Republic of Korea and an important vector of pathogens affecting both animals and humans, including severe fever with thrombocytopenia syndrome virus (SFTSV). <i>H. longicornis</i> occurs as both parthenogenetic and bisexual reproductive lineages that differ in geographic distribution and several biological characteristics. However, how differences in reproductive output, developmental timing, and stage-specific survival collectively influence their demographic performance remains poorly understood. In this study, we compared morphology, body weight, blood-feeding and post-feeding developmental periods, stage-specific survival, and reproductive output between parthenogenetic and bisexual lineages. Parthenogenetic females had larger idiosoma dimensions and attained heavier replete body weights than bisexual females. Parthenogenetic nymphs and adults completed blood feeding more rapidly, whereas larval pre-molting, pre-oviposition, and egg incubation periods were longer. Survival varied among developmental stages, with bisexual ticks showing higher survival during larval and adult reproductive transitions, including oviposition completion, whereas parthenogenetic ticks showed higher survival during the nymphal stage. Parthenogenetic females were estimated to produce more eggs than bisexual females (3,642 vs. 2,864 eggs per female), but cumulative stage-transition survival was substantially lower (0.155 vs. 0.450). Consequently, the estimated daily demographic growth factors were broadly comparable between the parthenogenetic and bisexual lineages (<i>λ</i>* = 1.0966 and 1.1054, respectively). These findings reveal that the higher reproductive output of parthenogenetic <i>H. longicornis</i> is counterbalanced by lower survival and longer development, highlighting contrasting life-history trade-offs rather than a simple demographic advantage of parthenogenesis.</p></div>","PeriodicalId":8281,"journal":{"name":"Archives of Insect Biochemistry and Physiology","volume":"123 3","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149311200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Designing Nanocarriers Around Insect Barriers: An Evidence Map for Double-Stranded RNA Delivery","authors":"Yasmeen Batool,&nbsp;Khinsha Sehar,&nbsp;Muhammad Zahid Ashraf,&nbsp;Sindho Wagan,&nbsp;Jingqing Chu,&nbsp;Zhou Wang,&nbsp;Chuanwang Cao,&nbsp;Lili Sun","doi":"10.1002/arch.70226","DOIUrl":"https://doi.org/10.1002/arch.70226","url":null,"abstract":"<div>\u0000 \u0000 <p>Nanocarriers are increasingly used to improve double-stranded RNA (dsRNA) delivery for insect functional genomics and pest management, but material-centered comparisons do not explain why similar formulations succeed in one species or exposure route and fail in another. Building on previous barrier-guided and polymer-focused reviews, this evidence map re-analyzes primary insect studies at the level of traceable delivery claims. A structured search through July 31, 2026 identified 41 eligible primary reports, which were mapped against route-dependent processes leading from exposure to intracellular availability, RNAi processing, and phenotype. Claim-specific appraisal profiles recorded formulation integrity, causal controls, molecular validation, and biological validity as separate domains. Chitosan, lipids, layered double hydroxides, cationic polymers, carbon materials, peptides, and porous frameworks can improve particularly measured delivery outcomes, but the evidence does not establish a universally superior carrier. Several characterized formulations improved stability, plant movement, tissue distribution, or uptake without establishing target-gene knockdown or linked phenotype, showing that physicochemical performance is not sufficient evidence of functional RNA interference. Nanocarriers were most defensible when tested against matched naked-dsRNA or non-nanocarrier comparators and when route-relevant integrity, sequence-specific silencing, and phenotype were demonstrated in the same experimental context. The proposed barrier map and claim categories are organizing tools for diagnosing delivery gaps; they require prospective validation before predictive use.</p></div>","PeriodicalId":8281,"journal":{"name":"Archives of Insect Biochemistry and Physiology","volume":"123 2","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149258712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrated Transcriptomic and Physiological Analyses Reveal Disruption of Digestive Homeostasis Induced by Protease Inhibitors in Anticarsia gemmatalis Caterpillars","authors":"Neilier Rodrigues da Silva Júnior,&nbsp;Eulálio Gutemberg Dias dos Santos,&nbsp;Daniel Guimarães Silva Paulo,&nbsp;Yaremis Meriño-Cabrera,&nbsp;Ian de Paula Alves Pinto,&nbsp;Maria Julia Summy,&nbsp;Ian Lucas Batista Santos,&nbsp;Milena Godoi Lima,&nbsp;Maria Clara Neves Gomes Rodrigues,&nbsp;Rafael Junior de Andrade,&nbsp;José Eduardo Serrão,&nbsp;Elizabeth Pacheco Batista Fontes,&nbsp;Humberto Josué Oliveira Ramos,&nbsp;Maria Goreti de Almeida Oliveira","doi":"10.1002/arch.70223","DOIUrl":"https://doi.org/10.1002/arch.70223","url":null,"abstract":"<p>Protease inhibitors (PIs) are promising bioactive compounds for sustainable pest management because they interfere with the digestive processes of herbivorous insects. However, the physiological mechanisms underlying insect adaptation to natural and synthetic PIs remain poorly understood. Here, we investigated the midgut responses of <i>Anticarsia gemmatalis</i> Hübner (Lepidoptera: Erebidae) to the soybean Kunitz trypsin inhibitor (SKTI) and the synthetic tripeptide GORE-2 using integrated transcriptomic, biochemical, and histological approaches, complemented by an exploratory metatranscriptomic analysis of putative gut-associated microbial transcripts. RNA-seq analysis identified 2542 unique differentially expressed genes (FDR-adjusted <i>p</i> &lt; 0.05, |log2FC | ≥ 1), including extensive modulation of digestive proteases and redox-related pathways. SKTI induced a compensatory response characterized by the up-regulation of serine proteases, antioxidant enzymes, and detoxification-associated pathways. In contrast, GORE-2 promoted broader repression of digestive proteases, including chymotrypsin- and trypsin-related transcripts and matrix metalloproteinases, together with a distinct antioxidant response. Biochemical assays demonstrated increased CAT, GST, POX, and SOD activities under both treatments. Compared with SKTI, GORE-2 induced lower POX, GST, and SOD activities, whereas CAT activity did not differ significantly between the two treatments. Histological analyses demonstrated notable epithelial disruption, vacuolization, and disorganization of the striated border in the larval midgut, with lesion scores being significantly elevated following GORE-2 exposure. Exploratory analysis of putative gut-associated microbial transcripts recovered from whole-midgut RNA-seq revealed taxonomically diverse microbial signals associated with carbon metabolism, proteolysis, and detoxification. However, no treatment-associated differential expression was detected among the putative bacterial transcripts. These findings indicate that GORE-2 induced broader disruption of digestive and protective midgut functions than SKTI, with weaker antioxidant enzyme induction and more pronounced histological injury, consistent with reduced physiological compensation in <i>A. gemmatalis</i> larvae. These results underscore the potential of synthetic peptide-based protease inhibitors to interfere with adaptive digestive processes in pest insects of agricultural importance.</p>","PeriodicalId":8281,"journal":{"name":"Archives of Insect Biochemistry and Physiology","volume":"123 2","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/arch.70223","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149099779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trypsinogen Pro-Region as a Molecular Scaffold for the Design of Competitive Peptide Inhibitors of Trypsin-Like Proteases","authors":"Geisiane Aparecida Mariano,&nbsp;João Vitor Aguilar de Oliveira,&nbsp;Rafael Júnior de Andrade,&nbsp;Daniel Guimarães Silva Paulo,&nbsp;Yaremis Beatriz Meriño Cabrera,&nbsp;Eulálio Gutemberg Dias dos Santos,&nbsp;Ian Lucas Batista Santos,&nbsp;Milena Godoi Lima,&nbsp;Maria Julia Summy,&nbsp;Otávio José Bernardes Brustolini,&nbsp;Neilier Rodrigues da Silva Júnior,&nbsp;Humberto Josué Oliveira Ramos,&nbsp;Maria Goreti de Almeida Oliveira","doi":"10.1002/arch.70224","DOIUrl":"https://doi.org/10.1002/arch.70224","url":null,"abstract":"<p>Soybean (<i>Glycine max</i> L. Merrill) productivity is severely impacted by the velvetbean caterpillar <i>Anticarsia gemmatalis</i> Hübner, 1818 (Lepidoptera: Erebidae), a major defoliating pest in soybean-producing regions. Current management strategies rely heavily on chemical insecticides, which are associated with environmental risks and the development of resistance. Protease inhibitors have emerged as a promising alternative, as protein digestion in lepidopteran larvae is primarily mediated by trypsin-like serine proteases. In this context, the rational design of short inhibitory peptides represents a potential strategy for developing selective and environmentally safer pest control agents. This study introduces the regulatory pro-region of trypsinogen as a previously underexplored scaffold for the rational design of competitive peptide inhibitors targeting digestive trypsin-like enzymes in agricultural insect pests. Fifteen peptides derived from the trypsinogen pro-region were initially <i>screened in silico</i> against <i>A. gemmatalis</i> trypsin-like enzymes. Molecular docking analyses revealed favorable binding energies and interactions with residues located in the catalytic region. Among the candidates, the peptide Pep12 (designated GORE3) was selected for further optimization by substituting amino acids at the P1 position, yielding the analogs GORE4 and GORE5. Enzyme inhibition assays with bovine trypsin and partially purified <i>A. gemmatalis</i> trypsin-like enzymes demonstrated that all peptides are competitive inhibitors. The inhibition constants (Ki) obtained for <i>A. gemmatalis</i> enzymes were 1.80 mM for GORE3, 1.63 mM for GORE4, and 0.78 mM for GORE5, with GORE5 exhibiting the lowest Ki among the evaluated peptides, although its inhibitory affinity remained within the millimolar range. Collectively, these findings underscore the potential of trypsinogen-derived peptides as promising scaffolds for developing peptide-based inhibitors targeting insect digestive proteases.</p>","PeriodicalId":8281,"journal":{"name":"Archives of Insect Biochemistry and Physiology","volume":"123 2","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/arch.70224","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149099780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nucleoplasmin-Like Protein, Expression Differences During the Caste Polyphenism Processes in Apis mellifera","authors":"Simona Sagona,&nbsp;Chiara D'Onofrio,&nbsp;Elena Tafi,&nbsp;Maria Gabriella Giuffrida,&nbsp;Francesca Coppola,&nbsp;Giulia Lazzarini,&nbsp;Andrea Pirone,&nbsp;Vincenzo Miragliotta,&nbsp;Antonio Felicioli","doi":"10.1002/arch.70221","DOIUrl":"10.1002/arch.70221","url":null,"abstract":"<div>\u0000 \u0000 <p>In honey bees, queen–worker differentiation is regulated by diet and begins after the first 3 days post-hatching. Several molecules and processes appear to be involved in caste polyphenism, including juvenile hormone, royalactin, and DNA methylation. A protease (PS4) was recently detected in worker larvae at 72 h post-hatching and shown to be inhibited by royal jelly, suggesting a potential role in this process. This study investigated the expression and tissue localization of nucleoplasmin during caste polyphenism in <i>Apis mellifera</i> larvae. A protein spot corresponding to a previously described caste-specific proteolytic activity was separated by 2DE and identified by mass spectrometry as a nucleoplasmin-like protein. Based on this result, a polyclonal antibody was raised against a conserved nucleoplasmin peptide and subsequently used for immunoproteomic and immunohistochemical analyses in worker- and queen-destined larvae. At this instar, Western blot analysis using a polyclonal anti–nucleoplasmin-like protein antibody revealed bands between 43–88 kDa and 74–104 kDa in worker- and queen-destined larvae, respectively, which may correspond to different polymeric conformations of the nucleoplasmin-like protein. Differences in the molecular mass of nucleoplasmin-like protein spots between worker and queen larvae suggest caste-specific roles during differentiation. Immunohistochemistry showed a ubiquitous nuclear distribution of the protein in undifferentiated larvae. Worker-fate larvae diverge from this pattern as early as Day 4, whereas queen-fate larvae retain a distribution like that of undifferentiated larvae, possibly representing the baseline developmental condition. Further studies examining temporal changes in nucleoplasmin-like protein expression between the third and fourth larval instars and during post-larval stages are desirable.</p></div>","PeriodicalId":8281,"journal":{"name":"Archives of Insect Biochemistry and Physiology","volume":"123 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149036421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"First Record of Cinara tujafilina (Hemiptera: Aphididae) in Myanmar Based on Morphological and Molecular Evidence","authors":"Minho Lee,&nbsp;Mariusz Kanturski,&nbsp;Seunghwan Lee","doi":"10.1002/arch.70217","DOIUrl":"10.1002/arch.70217","url":null,"abstract":"<div>\u0000 \u0000 <p>The cypress pine aphid, <i>Cinara</i> (<i>Cupressobium</i>) <i>tujafilina</i> (Del Guercio, 1909), is a widely distributed aphid associated with Cupressaceae and known for forming dense colonies that promote sooty mold development and reduce host vigour. Here, we report the first confirmed occurrence of this species in Myanmar. Specimens collected from <i>Platycladus orientalis</i> were identified using morphological characters and mitochondrial COI sequences. Genetic analyses revealed low intraspecific divergence and a clear barcode gap relative to closely related species, supporting accurate species identification. Haplotype network analysis showed that all Myanmar specimens belonged to a widespread haplotype shared with specimens from several other countries, with no private haplotypes detected. This study provides the first confirmed record of <i>C. tujafilina</i> in Myanmar and provides baseline information for future surveys of its distribution and host associations in the country.</p></div>","PeriodicalId":8281,"journal":{"name":"Archives of Insect Biochemistry and Physiology","volume":"123 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149036343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heavy Metal Tolerance in Lymantria dispar Larvae: Essential Roles of ABC Transporters in Resisting Heavy Metal Toxicity","authors":"Heyang Sun,&nbsp;Ying Wang,&nbsp;Yubin He,&nbsp;Chuang Xu,&nbsp;Shanchun Yan,&nbsp;Dun Jiang","doi":"10.1002/arch.70222","DOIUrl":"10.1002/arch.70222","url":null,"abstract":"<div>\u0000 \u0000 <p>Heavy metals are transported and accumulated along the food chain, exposing phytophagous insects to high risks of contamination. This study investigated the mechanisms underlying Pb and Cd tolerance in <i>Lymantria dispar</i> by focusing on the ABC transporter family. Multiple ABC genes in the larval midgut were significantly upregulated under Pb and Cd stress, respectively. Among them, <i>LdABC7</i> showed the most prominent positive response to Pb stress, and <i>LdABC12</i> to Cd stress. Following silencing of <i>LdABC7</i> or <i>LdABC12</i>, larval growth inhibition under heavy metal stress was significantly exacerbated and the expression of apoptosis-related genes was markedly up-regulated. Genes associated with the mitochondrial pathway shifted further toward pro-apoptosis after silencing of either <i>LdABC7</i> or <i>LdABC12</i>. At the cellular level, both LdABC7 and LdABC12 proteins were localized to the cell membrane. <i>Sf9</i> cells overexpressing these genes exhibited significantly increased cell viability, reduced apoptosis rates, restored mitochondrial membrane potential, reduced opening of the mitochondrial permeability transition pore (MPTP), and decreased levels of reactive oxygen species and calcium ions under heavy metal stress. Taken together, <i>LdABC7</i> and <i>LdABC12</i> serve as key detoxification components in <i>L. dispar</i> larvae in response to Pb and Cd stress, respectively, with the ability to maintain mitochondrial homeostasis and inhibit apoptosis.</p></div>","PeriodicalId":8281,"journal":{"name":"Archives of Insect Biochemistry and Physiology","volume":"123 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149036351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Curcumin Induces Autophagy Associated G1 Cell Cycle Arrest in Spodoptera frugiperda Sf9 Cells","authors":"Veeran Sethuraman,&nbsp;Shu Benshui,&nbsp;Jaganathan Ramakrishnan,&nbsp;Guohua Zhong","doi":"10.1002/arch.70220","DOIUrl":"10.1002/arch.70220","url":null,"abstract":"<div>\u0000 \u0000 <p>Curcumin, a plant-polyphenolic compound, has been reported to induce autophagy and autophagic cell death in insect cells but its impact on cell cycle regulation is not well understood. In this study, we investigated the short-term effects of curcumin on the cell proliferation, cell cycle progression and autophagy-associated cellular responses in the Sf9 insect cells of <i>Spodoptera frugiperda</i>. Short-term treatment of Sf9 cells with low-dose curcumin (5–15 µg/mL) resulted in a continuous decrease in cell proliferation in a dose and time dependent manner. Flow cytometric analysis showed a significant increase in the number of cells in the G 1 phase, indicating G 1 cell cycle arrest. This was also supported by nuclear morphology analysis using DAPI staining. Importantly, the growth inhibition caused by curcumin was not associated with apoptotic features or DNA fragmentation. Treatment with curcumin evoked a time-dependent increase in intracellular reactive oxygen species without significant mitochondrial membrane depolarization, indicating a controlled stress response instead of mitochondrial-dependent apoptosis. Scanning electron microscopy revealed significant surface morphological remodeling including cell shrinkage and membrane irregularities consistent with structural reorganization associated with autophagy. Molecular docking analysis using conserved insect cell cycle regulatory proteins supported a potential interaction of curcumin with G₁ phase cyclin-dependent kinases. Taken together, the findings demonstrate that curcumin induces autophagy-linked G₁ cell cycle arrest in Sf9 cells, extending previous observations of curcumin-induced autophagy and nucleophagy. This study highlights autophagy-mediated cell cycle regulation as a key mechanism underlying curcumin-induced growth suppression in insect cells and provides insight into the cellular actions of botanical bioactive compounds relevant to insect physiology.</p></div>","PeriodicalId":8281,"journal":{"name":"Archives of Insect Biochemistry and Physiology","volume":"123 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149036396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Biology, Ecology, and Pathogenesis of Borrelia burgdorferi Sensu Lato: Implications for Tick-Borne Disease and Prevention","authors":"Han Wang,&nbsp;Yahong Qiang,&nbsp;Lin Jin,&nbsp;Zhijun Yu","doi":"10.1002/arch.70219","DOIUrl":"10.1002/arch.70219","url":null,"abstract":"<div>\u0000 \u0000 <p><i>Borrelia burgdorferi</i> is a highly evolved extracellular pathogen that employs diverse strategies to persist within a complex enzootic cycle. As the causative agent of Lyme disease (LD), it has been the focus of extensive research into host–pathogen interactions, particularly its mechanisms of survival in reservoir hosts and transmission dynamics, significantly advancing the field of tick-borne diseases. This review summarized the discovery and development of <i>B. burgdorferi</i>, and contributed towards a holistic view on the transmission dynamics and pathogenic mechanisms, with emphasis on the complement evasion mechanisms of <i>B. burgdorferi</i>, which informed the current prevention efforts. Looking forward, the application of single-cell high-throughput sequencing is expected to elucidate novel molecular mechanisms underlying the transmission, and artificial intelligence technology holds promise for developing global tick-borne disease databases and public communication platforms to support future prevention strategies. Overall, this review provides an integrated framework that bridges molecular pathogenesis, ecological dynamics, and technological innovation to inform both fundamental research and public health responses to LD.</p></div>","PeriodicalId":8281,"journal":{"name":"Archives of Insect Biochemistry and Physiology","volume":"123 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149007669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}