Journal of Natural Products 最新文献

Discovery of Sporachelins by Genome Mining of a Micromonospora Strain. 通过小孢子菌株基因组挖掘发现孢子囊蛋白

IF 3.3 2区生物学

Journal of Natural Products Pub Date : 2024-11-19 DOI: 10.1021/acs.jnatprod.4c00860

Xiaomeng Hao, Gang Wu, Hu Li, Xin Xiang, Jixiang Xu, Yuyu Liu, Zhongke Jiang, Shaowei Liu, Adeela Fatima, Maira Saleem, Feina Li, Zonggen Peng, Chenghang Sun

{"title":"Discovery of Sporachelins by Genome Mining of a Micromonospora Strain.","authors":"Xiaomeng Hao, Gang Wu, Hu Li, Xin Xiang, Jixiang Xu, Yuyu Liu, Zhongke Jiang, Shaowei Liu, Adeela Fatima, Maira Saleem, Feina Li, Zonggen Peng, Chenghang Sun","doi":"10.1021/acs.jnatprod.4c00860","DOIUrl":"https://doi.org/10.1021/acs.jnatprod.4c00860","url":null,"abstract":"Myxochelins are a group of catecholate siderophores encoded by mxc biosynthetic gene clusters (BGCs). They are mainly produced by myxobacteria and display a wide variety of bioactivities. Herein, we report a group of new myxochelins produced not by a myxobacterial strain but by an actinobacteria strain, Micromonospora sp. TMD166. They consisted of six new compounds, designated as sporachelins A (1), A1 (2), B (3), C (4), D (5), and E (6), and the known compound myxochelin A (7). The planar structures were determined by comprehensive analyses of 1D and 2D NMR spectroscopic data, and the absolute configurations were confirmed by Marfey's analysis and chemical synthesis. The six sporachelins are the first examples of acylated derivatives at the primary alcohol of myxochelin A. These molecules were found to inhibit human 5-lipoxygenase. In addition, 1-7 exhibited antifibrotic activity in the TGFβ1-induced human hepatic cell line LX-2 by suppressing fibrosis-related genes COL1A1, ACTA2, and TGFB1 expression. This is the first report of antifibrotic activity by myxochelins.","PeriodicalId":47,"journal":{"name":"Journal of Natural Products ","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142666247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tyrosinase Inhibitory Properties of Compounds Isolated from Artocarpus integer Roots. 从整叶蒿根中分离出的化合物对酪氨酸酶的抑制特性

IF 3.3 2区生物学

Journal of Natural Products Pub Date : 2024-11-18 DOI: 10.1021/acs.jnatprod.4c00957

Ittipon Siridechakorn, Dina Nur Shinta, Ardiansah Ardiansah, Paratchata Batsomboon, Nattaya Ngamrojanavanich, Siwattra Choodej, Khanitha Pudhom

引用次数: 0

Discovery, Biosynthesis, Total Synthesis, and Biological Activities of Solanapyrones: [4 + 2] Cycloaddition-Derived Polyketides of Fungal Origin. Solanapyrones 的发现、生物合成、全合成和生物活性：源于真菌的 [4 + 2] 环加成多酮化合物。

IF 3.3 2区生物学

Journal of Natural Products Pub Date : 2024-11-15 DOI: 10.1021/acs.jnatprod.4c00818

Roberto G S Berlinck, Elizabeth Skellam

引用次数: 0

Discovery of Chalcone Derivatives as Bifunctional Molecules with Anti-SARS-CoV-2 and Anti-inflammatory Activities. 发现具有抗 SARS-CoV-2 和抗炎活性的双功能分子查尔酮衍生物

IF 3.3 2区生物学

Journal of Natural Products Pub Date : 2024-11-14 DOI: 10.1021/acs.jnatprod.4c00657

Xuwen Chen, Hongtao Li, Meiting Wang, Donghui Sun, Jiani Lu, Tong Zhu, Hongzhuan Chen, Lili Chen, Shunying Liu

{"title":"Discovery of Chalcone Derivatives as Bifunctional Molecules with Anti-SARS-CoV-2 and Anti-inflammatory Activities.","authors":"Xuwen Chen, Hongtao Li, Meiting Wang, Donghui Sun, Jiani Lu, Tong Zhu, Hongzhuan Chen, Lili Chen, Shunying Liu","doi":"10.1021/acs.jnatprod.4c00657","DOIUrl":"https://doi.org/10.1021/acs.jnatprod.4c00657","url":null,"abstract":"Danshensu extracted with traditional Chinese medicine Salvia miltiorrhiza has a wide range of bioactivities. Danshensu containing a catechol moiety has a moderate inhibitory effect on SARS-CoV-2 3CLpro (IC50 = 2.2 μM) by a reversible covalent interaction and exhibits good anti-inflammatory activity. To enhance the inhibitory activity, we introduced Michael receptors into the side chain of danshensu as a possible covalent warhead and blocked the covalent binding sites of catechol moiety to yield chalcone derivatives. The resulting chalcone derivatives, A4 and A7, were found to inhibit SARS-CoV-2 3CLpro in vitro with IC50 values of 83.2 and 261.3 nM, respectively. Furthermore, A4 and A7 inhibit viral replication in the SARS-CoV-2 replicon system with EC50 values of 19.9 and 11.7 μM, respectively. Time-dependent inhibition experiment and mass spectrometry show that A4 acted as a noncovalent mixed inhibitor, while A7 likely binds covalently at Cys145. The interaction mechanism between SARS-CoV-2 3CLpro and A4 or A7 was characterized by molecular docking studies. Additionally, both A4 and A7 demonstrated potent anti-inflammatory activity in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophage cells. These promising results suggest that chalcone derivatives A4 and A7 can serve as bifunctional molecules with both antivirus and anti-inflammatory properties.","PeriodicalId":47,"journal":{"name":"Journal of Natural Products ","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142612705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Expression of Concern for "Tepuazines A-E: Phenazine Glycosides from a Venezuelan Quartz-Rich (Tepui) Cave Soil-Derived Streptomyces virginiae CMB-CA091". 表达对 "Tepuazines A-E: Phenazine Glycosides from a Venezuelan Quartz-Rich (Tepui) Cave Soil-Derived Streptomyces virginiae CMB-CA091 "的关注。

IF 3.3 2区生物学

Journal of Natural Products Pub Date : 2024-11-13 DOI: 10.1021/acs.jnatprod.4c01237

Philip J Proteau

引用次数: 0

Pullenvalenes E-H: Triterpenyl-Aminoglycosides from an Australian Soil-Derived Fungus, Clonostachys sp. Pullenvalenes E-H: Triterpenyl-Aminoglycosides from an Australian Soil-Derived Fungus, Clonostachys sp.

IF 3.3 2区生物学

Journal of Natural Products Pub Date : 2024-11-12 DOI: 10.1021/acs.jnatprod.4c01068

Yanan Wang, Jolynn Kiong, Amila Agampodi Dewa, Angela A Salim, Zeinab G Khalil, Robert J Capon

{"title":"Pullenvalenes E-H: Triterpenyl-Aminoglycosides from an Australian Soil-Derived Fungus, Clonostachys sp.","authors":"Yanan Wang, Jolynn Kiong, Amila Agampodi Dewa, Angela A Salim, Zeinab G Khalil, Robert J Capon","doi":"10.1021/acs.jnatprod.4c01068","DOIUrl":"https://doi.org/10.1021/acs.jnatprod.4c01068","url":null,"abstract":"Chemical profiling of soil-derived microbes collected under the auspices of the Australian citizen science initiative Soils for Science detected two fungi, Clonostachys sp. S4S-07771A07 and Coccidiodes sp. S4S-14879B01, capable of producing pullenvalenes, a rare class of triterpene glycoside. Cultivation profiling followed by scaled up cultivation and fractionation of the former yielded the known pullenvalenes A-D (1-4) and the new analogues E-H (5-8), with structures secured by detailed spectroscopic analysis and biogenetic considerations. This study reveals that the pullenvalenes 1-8 are produced by several genera of fungi (Clonostachys, Coccidiodes and Talaromyces) recovered from different geographic locations and substrates. We also draw attention to structural and biosynthetic similarities with the known Red Sea sponge metabolites neviotines A-D (9-12) and abudinols A-B (13-14), prompting speculation that the latter may be products of sponge-associated fungi.","PeriodicalId":47,"journal":{"name":"Journal of Natural Products ","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142612710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring Biological Targets of Magnolol and Honokiol and their Nature-Inspired Synthetic Derivatives: In Silico Identification and Experimental Validation of Estrogen Receptors. 探索 Magnolol 和 Honokiol 及其自然启发合成衍生物的生物靶标：雌激素受体的硅学鉴定和实验验证。

IF 3.3 2区生物学

Journal of Natural Products Pub Date : 2024-11-11 DOI: 10.1021/acs.jnatprod.4c00634

Annachiara Tinivella, Jerome C Nwachukwu, Luca Pinzi, Maria Antonietta Dettori, Davide Fabbri, Paola Carta, Kendall W Nettles, Giulio Rastelli

{"title":"Exploring Biological Targets of Magnolol and Honokiol and their Nature-Inspired Synthetic Derivatives: In Silico Identification and Experimental Validation of Estrogen Receptors.","authors":"Annachiara Tinivella, Jerome C Nwachukwu, Luca Pinzi, Maria Antonietta Dettori, Davide Fabbri, Paola Carta, Kendall W Nettles, Giulio Rastelli","doi":"10.1021/acs.jnatprod.4c00634","DOIUrl":"https://doi.org/10.1021/acs.jnatprod.4c00634","url":null,"abstract":"In this work, we describe the results of a computational investigation aimed at identifying potential biological targets of honokiol, magnolol and a series of synthetic prodrug derivatives obtained through esterification of the free hydroxyl groups. The ligand-based and structure-based analyses revealed that these compounds potentially interact with several biological targets, some of which are known while others are new. Honokiol, magnolol, and three of the newly synthesized derivatives may bind to estrogen receptors ERα and ERβ. Biological testing confirmed that these compounds modulate estrogen-regulated transcriptional activity mediated by ERα or ERβ with potencies in the nanomolar range. In particular, magnolol and one of its derivatives (10) behaved as partial antagonists of ERα and ERβ, while compounds 8 and 11 behaved as partial agonists. These findings validate the computational predictions and shed light on the mechanism of action of these natural compounds, paving the way for further investigation in the context of targeted therapies.","PeriodicalId":47,"journal":{"name":"Journal of Natural Products ","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142612707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Addition to "Natural and Semisynthetic Chalcones as Dual FLT3 and Microtubule Polymerization Inhibitors". 添加到 "作为 FLT3 和微管聚合双重抑制剂的天然和半合成查耳酮"。

IF 3.3 2区生物学

Journal of Natural Products Pub Date : 2024-11-11 DOI: 10.1021/acs.jnatprod.4c01252

Haleema Sadia Malik, Aishah Bilal, Rahim Ullah, Maheen Iqbal, Sardraz Khan, Ishtiaq Ahmed, Karsten Krohn, Rahman Shah Zaib Saleem, Hidayat Hussain, Amir Faisal

引用次数: 0