Journal of Natural Products 最新文献_第10页

MDN-0057 to MDN-0060, a Family of Broad-Spectrum Antibiotics against Gram-Negative Pathogens Produced by Ophiosphaerella korrae.

IF 3.3 2区生物学

Journal of Natural Products Pub Date : 2025-02-28 Epub Date: 2025-02-02 DOI: 10.1021/acs.jnatprod.4c01289

Ignacio Pérez-Victoria, Noureddine El Aouad, Víctor González-Menéndez, Mercedes de La Cruz, Lidia Lorenzo Fernández, Jesús Martín, José R Tormo, Grégory Genta-Jouve, Olivier P Thomas, Francisca Vicente, Gerald F Bills, Olga Genilloud, Fernando Reyes

引用次数: 0

Dihydroaurones and Isoflavan Derivatives from the Roots of Glycyrrhiza asymmetrica.

IF 3.3 2区生物学

Journal of Natural Products Pub Date : 2025-02-28 Epub Date: 2025-01-28 DOI: 10.1021/acs.jnatprod.4c00878

Dicle Çevik, Milena Masullo, Gianluigi Lauro, Assunta Napolitano, Stefania Martucciello, Gaetana Paolella, Luciana Maria Polcaro, Giuseppe Bifulco, Hasan Kırmızıbekmez, Sonia Piacente

{"title":"Dihydroaurones and Isoflavan Derivatives from the Roots of Glycyrrhiza asymmetrica.","authors":"Dicle Çevik, Milena Masullo, Gianluigi Lauro, Assunta Napolitano, Stefania Martucciello, Gaetana Paolella, Luciana Maria Polcaro, Giuseppe Bifulco, Hasan Kırmızıbekmez, Sonia Piacente","doi":"10.1021/acs.jnatprod.4c00878","DOIUrl":"10.1021/acs.jnatprod.4c00878","url":null,"abstract":"As a continuation of our pharmacognostic studies on different Glycyrrhiza species growing in Türkiye, the phytochemical investigation of the roots of Glycyrrhiza asymmetrica Hub.-Mor., a licorice species endemic to Türkiye, was carried out. This study yielded twenty-three secondary metabolites (1-23) including nine previously unreported compounds: two dihydroaurone-3-enoic acids, licoaurone A (1) and licoaurone B (2), isoflavan hydroxypreglabridin (3), isoflavanone cyclodeoxykievitone (4), flavanone-3-ol glycyasymmetrol (5), and four bi-isoflavans, glycyasymmetrica A-D (6-9). The structures of isolated compounds were established by NMR and MS experiments. The relative configurations (6-9) were assigned by a combined quantum mechanical/NMR approach, comparing the experimental 13C/1H NMR chemical shift data and the related predicted values. The absolute configurations of compounds 1-9 were assigned by comparison of their experimental electronic circular dichroism curves with the TDDFT-predicted curves. All isolated compounds were also evaluated for their cytotoxic activity against MCF-7, HeLa, HepG2, and A549 cancer cell lines by using MTT assay.","PeriodicalId":47,"journal":{"name":"Journal of Natural Products ","volume":" ","pages":"294-305"},"PeriodicalIF":3.3,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143051058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Discovery and Characterization of a Fungal N-acetylglucosamine Transferase in the Biosynthesis of Furanone Glycosides.

IF 3.3 2区生物学

Journal of Natural Products Pub Date : 2025-02-28 Epub Date: 2025-01-30 DOI: 10.1021/acs.jnatprod.4c01190

Yongchun Zhu, Xianyan Zhang, Chuanteng Ma, Xingtao Ren, Wenxue Wang, Kaijin Zhang, Guojian Zhang, Qian Che, Tianjiao Zhu, Dehai Li

引用次数: 0

Jejupeptins A and B: Polyketide-Cyclic Peptide Hybrids with Anti-Corticosterone Activity from Streptomyces sp. KCB15JA151.

IF 3.3 2区生物学

Journal of Natural Products Pub Date : 2025-02-28 Epub Date: 2025-02-04 DOI: 10.1021/acs.jnatprod.4c01201

Jun-Pil Jang, Jongtae Roh, Gil Soo Kim, Jihun Park, Gwi Ja Hwang, Beomcheol Park, Hyeok-Won Lee, Shunji Takahashi, Young-Soo Hong, Sung-Kyun Ko, Jae-Hyuk Jang

引用次数: 0

Ion Mobility-Coupled Mass Spectrometry for Metallophore Detection.

IF 3.3 2区生物学

Journal of Natural Products Pub Date : 2025-02-28 Epub Date: 2025-02-10 DOI: 10.1021/acs.jnatprod.4c00911

Bailey A Bell, Josephine M Anderson, Scott R Rajski, Tim S Bugni

{"title":"Ion Mobility-Coupled Mass Spectrometry for Metallophore Detection.","authors":"Bailey A Bell, Josephine M Anderson, Scott R Rajski, Tim S Bugni","doi":"10.1021/acs.jnatprod.4c00911","DOIUrl":"10.1021/acs.jnatprod.4c00911","url":null,"abstract":"Metal chelating small molecules (metallophores) play significant roles in microbial interactions and bacterial survival; however, current methods to identify metallophores are limited by low sensitivity, a lack of metal selectivity, and/or complicated data analysis. To overcome these limitations, we developed a novel approach for detecting metallophores in natural product extracts using ion mobility-coupled mass spectrometry (IM-MS). As a proof of concept, marine bacterial extracts containing known metallophores were analyzed by IM-MS with and without added metals, and the data were compared between conditions to identify metal-binding metabolites. Ions with changes in both mass and mobility were specific to metallophores, enabling their identification within these complex extracts. Additionally, we compared the use of direct infusion (DI) and liquid chromatography (LC) separation with IM-MS. For most samples, DI outperformed LC by minimizing the time required for data collection and simplifying analysis. However, for some samples, LC improved the detection of metallophores likely by reducing ion suppression. IM-MS was then used to identify 10 metallophores in an extract from a marine Micromonospora sp. Overall, incorporating IM-MS facilitated the rapid detection of metal-binding natural products in complex bacterial extracts through the comparison of mass and mobility data in the presence and absence of metals.","PeriodicalId":47,"journal":{"name":"Journal of Natural Products ","volume":" ","pages":"306-313"},"PeriodicalIF":3.3,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143389512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cyclodepsipeptides and Fatty Acid Lactones from the Freshwater-Derived Fungus, Talaromyces gwangjuensis, and Their Potential as Autophagy Activators.

IF 3.3 2区生物学

Journal of Natural Products Pub Date : 2025-02-28 Epub Date: 2025-02-12 DOI: 10.1021/acs.jnatprod.4c01172

Van-Hieu Mai, Seri Choi, Jorge-Eduardo Ponce-Zea, Thuong T T Nguyen, Hyung-Sik Kang, Heejung Yang, Hyang Burm Lee, Won-Keun Oh

{"title":"Cyclodepsipeptides and Fatty Acid Lactones from the Freshwater-Derived Fungus, Talaromyces gwangjuensis, and Their Potential as Autophagy Activators.","authors":"Van-Hieu Mai, Seri Choi, Jorge-Eduardo Ponce-Zea, Thuong T T Nguyen, Hyung-Sik Kang, Heejung Yang, Hyang Burm Lee, Won-Keun Oh","doi":"10.1021/acs.jnatprod.4c01172","DOIUrl":"10.1021/acs.jnatprod.4c01172","url":null,"abstract":"Autophagy is a primary cellular mechanism that entails the degradation and recycling of impaired or redundant cellular constituents. It plays an essential role in maintaining cellular health and homeostasis. Dysfunction in autophagy has been implicated in a wide range of diseases, including cancer, cardiovascular diseases, and neurodegenerative diseases. A total of 200 fungal extracts were screened for their ability to modulate autophagy in HEK293A cells, a human kidney cell line stably expressing GFP-tagged LC3, a marker of autophagy. A potential autophagy regulator extract was identified from the freshwater-derived fungus, Talaromyces gwangjuensis. Through the implementation of Feature-Based Molecular Networking (FBMN), seven cyclodepsipeptides (1-7) and four lactone derivatives (8-11) were isolated from the bioactive fractions. The chemical structure of the newly isolated compounds, arthrichitins E-H (1-4) and gwangjupones A-D (8-11), were elucidated using 1D and 2D NMR spectroscopy, Marfey's analysis, J-based configuration analysis, ECD, and DP4+ probability calculations. Compounds 1, 4, and 6 were found to stimulate autophagic flux in IMR90 cells infected with an adeno-associated virus carrying an mCherry-GFP-LC3 construct, highlighting their potential as autophagy activators.","PeriodicalId":47,"journal":{"name":"Journal of Natural Products ","volume":" ","pages":"384-396"},"PeriodicalIF":3.3,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143397601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Total Synthesis of the Furopyran Lignans Sumatranin A-D and the Proposed Structure of Sumatranin H.

IF 3.3 2区生物学

Journal of Natural Products Pub Date : 2025-02-28 Epub Date: 2025-02-18 DOI: 10.1021/acs.jnatprod.4c01466

Zong Hao Jia, Lisa I Pilkington, David Barker

引用次数: 0

Semi-Synthesis of Dimeric Cannabidiol Derivatives and Evaluation of their Affinity at Neurological Targets.

IF 3.3 2区生物学

Journal of Natural Products Pub Date : 2025-02-28 Epub Date: 2025-01-24 DOI: 10.1021/acs.jnatprod.4c01174

Zachary Stryker, Jorge I Castillo-Arellano, Stephen J Cutler, Michael D Wyatt, Francisco León

{"title":"Semi-Synthesis of Dimeric Cannabidiol Derivatives and Evaluation of their Affinity at Neurological Targets.","authors":"Zachary Stryker, Jorge I Castillo-Arellano, Stephen J Cutler, Michael D Wyatt, Francisco León","doi":"10.1021/acs.jnatprod.4c01174","DOIUrl":"10.1021/acs.jnatprod.4c01174","url":null,"abstract":"Cannabidiol (CBD) is a natural product associated with a wide range of biological and therapeutic activities. Despite the widespread cultural acceptance of CBD as a medicinal agent, much remains to be determined regarding its precise mechanism(s) of action in treating multiple conditions. CBD has been shown to promiscuously interact with several neurological targets with varying affinities. To expand the chemical space of phytocannabinoids and develop novel chemical compounds, we have designed and synthesized a series of CBD and Δ8-THC homodimers, and CBD/Δ8-THC heterodimers. The capacity of the dimers to interact with a panel of CNS targets was explored along with the capacity to activate CB1 receptors, as measured by a GIRK channel activation assay. In the panel screen, the dimers were shown to be generally more active toward 5-HT2B and sigma 2 receptors with a range of Ki values from 0.6 to 8.7 μM. These findings provide early evidence that this new class of dimers can serve as novel chemical entities to explore receptor function and the potential for these dimers to have bivalent, bitopic, or dual mechanisms of action.","PeriodicalId":47,"journal":{"name":"Journal of Natural Products ","volume":" ","pages":"397-414"},"PeriodicalIF":3.3,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143031528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chamilactones A and B, Sesquiterpenes from the Endophytic Fungus Chaetomium nigricolor F5.

IF 3.3 2区生物学

Journal of Natural Products Pub Date : 2025-02-28 Epub Date: 2025-01-30 DOI: 10.1021/acs.jnatprod.4c01229

Yan-Jun Sun, Jin-Zhi Pan, Shuang-Zhi Yuan, Rémy Bertrand Teponno, Xue-Yan Feng, Xiao-Ping Peng, Qian Luo, Hong-Xiang Lou, Gang Li

引用次数: 0

A Model for STEM Education: The Role of Natural Products at Drew University.

IF 3.3 2区生物学

Journal of Natural Products Pub Date : 2025-02-28 Epub Date: 2025-02-07 DOI: 10.1021/acs.jnatprod.5c00117

Vincent P Gullo

引用次数: 0