ACS Applied Bio Materials最新文献

Plasmonic Enhanced Nonlinear Absorption of Tris(2-aminoethyl)amine (TREN) Functional Ag, Pt, and Pd Nanoparticle-GQDs Complexes and Their Evaluation as Potential Bioimaging Applications. 三（2-氨基乙基）胺（TREN）功能银、铂和钯纳米粒子- gqds配合物的等离子体增强非线性吸收及其在生物成像中的潜在应用

IF 4.6

ACS Applied Bio Materials Pub Date : 2025-07-01 DOI: 10.1021/acsabm.5c00750

Bekir Asilcan Unlu, Esen Kirit, Dogantan Celik, Elif Akhuseyin Yildiz, Ahmet Karatay, Bahadir Boyacioglu, Hüseyin Ünver, Açelya Yilmazer, Mustafa Yıldız, Ayhan Elmali

{"title":"Plasmonic Enhanced Nonlinear Absorption of Tris(2-aminoethyl)amine (TREN) Functional Ag, Pt, and Pd Nanoparticle-GQDs Complexes and Their Evaluation as Potential Bioimaging Applications.","authors":"Bekir Asilcan Unlu, Esen Kirit, Dogantan Celik, Elif Akhuseyin Yildiz, Ahmet Karatay, Bahadir Boyacioglu, Hüseyin Ünver, Açelya Yilmazer, Mustafa Yıldız, Ayhan Elmali","doi":"10.1021/acsabm.5c00750","DOIUrl":"https://doi.org/10.1021/acsabm.5c00750","url":null,"abstract":"Tris (2-aminoethyl)amine (TREN) functionalized N-doped graphene quantum dots (N-GQDs) and their Ag, Pd, and Pt nanocomposites were synthesized via a green one-step method and comprehensively characterized using FT-IR, UV-vis, TEM, and EDX. Spectroscopic analysis revealed π-π* transitions of C═C bonds (245-250 nm) and n-π* transitions of C═O and C═N bonds (334-350 nm), elucidating the materials' optical properties. Photoluminescence studies revealed excitation wavelength-dependent emissions, indicating the presence of edge defect levels. Femtosecond transient absorption spectroscopy revealed a shortened excited-state lifetime upon incorporation of a metal atom into TREN-GQDs. Nonlinear absorption was explored by using the open-aperture Z-scan method, revealing enhanced performance upon incorporation of plasmonic nanoparticles. Ag-incorporated samples exhibited the highest NLA response due to plasmon-enhanced two-photon absorption. Notably, Pt-incorporated N-GQDs showed improved NLA and good biocompatibility with the intracellular fluorescence response, positioning them as promising candidates for bioimaging applications. Density functional theory (DFT) calculations, including gas-phase optimizations and aqueous simulations, confirmed alignment with experimental results, highlighting the enhanced stability and reactivity of nanocomposites. These findings highlight the potential of these materials in various applications, such as optical limiting, imaging, photovoltaics, and sensing applications.","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144525236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

COVID-19 vaccination rates among healthcare workers by immigrant background: A nation-wide registry study from Norway. 按移民背景划分的医护人员 COVID-19 疫苗接种率：挪威全国登记研究。

IF 4.6

ACS Applied Bio Materials Pub Date : 2025-07-01 Epub Date: 2022-09-28 DOI: 10.1177/14034948221100685

Kristian Bandlien Kraft, Ingeborg Elgersma, Trude Marie Lyngstad, Petter Elstrøm, Kjetil Telle

{"title":"COVID-19 vaccination rates among healthcare workers by immigrant background: A nation-wide registry study from Norway.","authors":"Kristian Bandlien Kraft, Ingeborg Elgersma, Trude Marie Lyngstad, Petter Elstrøm, Kjetil Telle","doi":"10.1177/14034948221100685","DOIUrl":"10.1177/14034948221100685","url":null,"abstract":"Aims: Studies have suggested that some minority groups tend to have lower vaccination rates than the overall population. This study aims to examine COVID-19 vaccination rates among healthcare workers in Norway, according to immigrant background.Methods: We used individual-level, nation-wide registry data from Norway to identify all healthcare workers employed full time at 1 December 2020. We examined the relationship between country of birth and COVID-19 vaccination from December 2020 to August 2021, both crude and adjusted for, for example, age, sex, municipality of residence and detailed occupation codes in logistic regression models.Results: Among all healthcare workers in Norway, immigrants had a 9 percentage point lower vaccination rate (85%) than healthcare workers without an immigrant background (94%) at 31 August 2021. The overall vaccination rate varied by country of birth, with immigrants born in Russia (71%), Serbia (72%), Lithuania (72%), Romania (75%), Poland (76%), Eritrea (77%) and Somalia (78%) having the lowest crude vaccination rates. When we adjusted for demographics and detailed occupational codes, immigrant groups that more often worked as healthcare assistants, such as immigrants from Eritrea and Somalia, increased their vaccination rates.Conclusions: \u0000 Substantial differences in vaccination rates among immigrant groups employed in the healthcare sector in Norway indicate that measures to improve vaccine uptake should focus on specific immigrant groups rather than all immigrants together. Lower vaccination rates in some immigrant groups appear to be largely driven by the occupational composition, suggesting that some of the differences in vaccine rates can be attributed to variation in vaccine access.\u0000 ","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":" ","pages":"447-455"},"PeriodicalIF":4.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40382092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Feasibility Study of Group Schema Therapy with Psychomotor Therapy for Older Adults with a Cluster B or C Personality Disorder. 针对患有 B 类或 C 类人格障碍的老年人的集体模式疗法与心理运动疗法的可行性研究。

IF 4.6

ACS Applied Bio Materials Pub Date : 2025-07-01 Epub Date: 2022-07-16 DOI: 10.1080/07317115.2022.2099330

Silvia D M van Dijk, Renske Bouman, Ewa H Folmer, Sebastiaan P J van Alphen, Rob H S van den Brink, Richard C Oude Voshaar

{"title":"A Feasibility Study of Group Schema Therapy with Psychomotor Therapy for Older Adults with a Cluster B or C Personality Disorder.","authors":"Silvia D M van Dijk, Renske Bouman, Ewa H Folmer, Sebastiaan P J van Alphen, Rob H S van den Brink, Richard C Oude Voshaar","doi":"10.1080/07317115.2022.2099330","DOIUrl":"10.1080/07317115.2022.2099330","url":null,"abstract":"Objectives: Schema group therapy is an effective treatment for personality disorders, but its focus on cognitive techniques may be a limitation for older adults. This article describes the rationale and initial evaluation of a group schema therapy protocol enriched with psychomotor therapy (GST+PMT) for older adults in geriatric mental health care.Methods: Within an observational feasibility study, we evaluated the effect of a 26-week GST+PMT program in 19 outpatients aged 60-70 years with a cluster B or C personality disorder on the Young Schema Questionnaire, Schema Mode Inventory and Manchester Short Assessment of Quality of Life. Cohen's d effect-sizes were calculated between baseline (T0), mid-treatment (T1) and end-of-treatment (T2).Results: Medium to large pre-post effect-sizes (T0-T2) were found for all outcome measures. Most improvement of schema modes occurred between T0-T1, and of schemas and quality of life between T1-T2.Conclusions: Group schema therapy enriched with PMT is feasible in later life and its effect might be mediated by targeting schema modes. Future research would be helpful, including larger samples and controlled studies.Clinical implications: For older adults suffering from personality disorders B or C verbal schema group therapy enriched with non-verbal PMT may be an effective treatment.","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":" ","pages":"772-778"},"PeriodicalIF":4.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40613971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bifunctional Metal Ion-Enhanced PDA-Coated Titanium for Superior Osteogenic and Antimicrobial Performance. 双功能金属离子增强pda涂层钛具有优异的成骨和抗菌性能。

IF 4.6

ACS Applied Bio Materials Pub Date : 2025-06-30 DOI: 10.1021/acsabm.4c01869

Chenhui Liu, Sikun Meng, Huachun Wang, Tianzhen Zhang, Cheng Qi, Mei Li, Jingyang Kang

{"title":"Bifunctional Metal Ion-Enhanced PDA-Coated Titanium for Superior Osteogenic and Antimicrobial Performance.","authors":"Chenhui Liu, Sikun Meng, Huachun Wang, Tianzhen Zhang, Cheng Qi, Mei Li, Jingyang Kang","doi":"10.1021/acsabm.4c01869","DOIUrl":"https://doi.org/10.1021/acsabm.4c01869","url":null,"abstract":"Titanium (Ti) implants serve as a popular solution for tooth replacement, because they combine excellent mechanical properties with high biocompatibility. However, the biologically inert nature of titanium surfaces restricts their osteogenic capacity and renders them prone to bacterial colonization, elevating the risk of biofilm formation and implant-associated infections. Surface modification of titanium implants is essential to overcoming these limitations. To optimize the titanium surface functionality, this study employed a polydopamine (PDA) coating strategy combined with subsequent incorporation of copper and manganese ions. We prepared Ti-PDA and then fabricated Ti-PDA-Cu and Ti-PDA-Cu/Mn samples. Material characterization revealed that Ti-PDA-Cu/Mn exhibits favorable surface wettability and biocompatibility, along with sustained and stable release of Cu2+ and Mn2+ ions. Experiments in vitro showed that Ti-PDA-Cu/Mn had good antimicrobial activity against Escherichia coli and Staphylococcus aureus, significantly promoted protein adsorption, osteoblast adhesion, proliferation, and mineralization, and upregulated the expression of osteogenic genes. A promising strategy has been established through this bifunctional modification to simultaneously enhance the osteogenic and antimicrobial properties of titanium implants.","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144525233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fibroblast Morphology, Adhesion, and Extracellular Matrix Secretion in Columnar Microarray Hydroxyapatite. 柱状微阵列羟基磷灰石的成纤维细胞形态、粘附和细胞外基质分泌。

IF 4.6

ACS Applied Bio Materials Pub Date : 2025-06-30 DOI: 10.1021/acsabm.5c00595

Takuma Watanabe, Gerardo Martin Quindoza, Yuta Aida, Hayato Laurence Mizuno, Yasutaka Anraku, Toshiyuki Ikoma

引用次数: 0

Bacterial Cellulose-Based Laser-Scribed Graphene Electrode for Hydrogen Peroxide Detection in Cancer Cells. 细菌纤维素基激光刻写石墨烯电极用于肿瘤细胞过氧化氢检测。

IF 4.6

ACS Applied Bio Materials Pub Date : 2025-06-29 DOI: 10.1021/acsabm.5c00825

Lucas F de Lima, André L Ferreira, Letícia Ester Dos Santos, Keyla Lívian P Coelho, Keyla Teixeira Santos, Ariane Schmidt, Marcelo Bispo de Jesus, Thiago R L C Paixão, William R de Araujo

{"title":"Bacterial Cellulose-Based Laser-Scribed Graphene Electrode for Hydrogen Peroxide Detection in Cancer Cells.","authors":"Lucas F de Lima, André L Ferreira, Letícia Ester Dos Santos, Keyla Lívian P Coelho, Keyla Teixeira Santos, Ariane Schmidt, Marcelo Bispo de Jesus, Thiago R L C Paixão, William R de Araujo","doi":"10.1021/acsabm.5c00825","DOIUrl":"https://doi.org/10.1021/acsabm.5c00825","url":null,"abstract":"The development of sustainable and high-performance electrochemical sensors is crucial for advancing biomedical applications. In this work, we introduce a hydrogen peroxide (H2O2) sensor based on bacterial cellulose-derived laser-scribed graphene (BC-LSG), modified with MXene and platinum nanoparticles (PtNPs). Bacterial cellulose (BC), a biodegradable and renewable material, was cultivated and transformed into a highly conductive carbon network using CO2 laser irradiation, producing a flexible, portable, and miniaturized electrochemical platform. The incorporation of MXene and PtNPs significantly enhanced the electrocatalytic response toward H2O2 oxidation, achieving a wide linear concentration range (15-95 μmol L-1) and a low detection limit (0.35 μmol L-1). Compared to traditional enzymatic sensors, our nanostructured BC-LSG device offers superior stability, reproducibility, and eco-friendliness, aligning with green analytical chemistry principles. The sensor was successfully applied for H2O2 detection in mammalian cells, demonstrating its potential for real-time monitoring of oxidative stress, a key biomarker in cancer progression and therapeutic responses. This work underscores the synergy between biopolymeric materials, nanotechnology, and laser processing, opening new avenues for scalable, disposable, and sustainable electrochemical devices.","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144525232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanobody Coupled with Au Nanoparticle Cluster to Detect Survivin Protein by Lateral Flow Immunoassay. 纳米体偶联金纳米颗粒簇检测Survivin蛋白的横向流动免疫分析。

IF 4.6

ACS Applied Bio Materials Pub Date : 2025-06-28 DOI: 10.1021/acsabm.5c00745

Yujiao Tang, Xiaomin Zhao, Zhenlin Nie, Bangshun He, Dawei Deng

{"title":"Nanobody Coupled with Au Nanoparticle Cluster to Detect Survivin Protein by Lateral Flow Immunoassay.","authors":"Yujiao Tang, Xiaomin Zhao, Zhenlin Nie, Bangshun He, Dawei Deng","doi":"10.1021/acsabm.5c00745","DOIUrl":"https://doi.org/10.1021/acsabm.5c00745","url":null,"abstract":"The monoclonal antibody (mAb) used in a traditional Lateral Flow Immunoassay (LFIA) has many limitations, particularly related to its poor affinity, specificity, and stability. In this study, a nanobody (VHH) was developed with improved tolerability and higher specificity for the target. The strong binding affinity between VHH and survivin was emphasized by simulated docking, demonstrating the feasibility and effectiveness of replacing mAb in the detection of urinary survivin based on LFIA. In addition, the superior performance of VHH compared with mAb under extreme conditions was highlighted. To further enhance the detection performance, VHH was conjugated with an Au nanoparticle cluster (AuNP cluster). The pore size structure of the AuNP cluster led to an increased abundance of AuNPs, which amplified the signal while providing adequate adsorption sites for VHH coupling, thereby achieving a synergistic enhancement in the sensitivity and specificity of the AuNP cluster-VHH probe. Consequently, the detection limit for survivin was established at 3.90 ng/mL, facilitating noninvasive detection and monitoring in early-stage bladder cancer and during post-treatment surveillance. This insight underscores the key role of VHH in enhancing the performance of LFIA and the potential of developing a promising detection tool based on urinary biomarkers.","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144525235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chitin-Core Chitosan-Sheath Nanowhiskers as a Multifunctional Bionanofiber Modality for Hydrogel Microspheres in a Micromolding-Based Fabrication-Conjugation Approach. 几丁质核壳聚糖鞘纳米须作为水凝胶微球的多功能生物纳米纤维形态。

IF 4.6

ACS Applied Bio Materials Pub Date : 2025-06-27 DOI: 10.1021/acsabm.5c00632

Alec K Zackin, Subhash Kalidindi, Hyunmin Yi

{"title":"Chitin-Core Chitosan-Sheath Nanowhiskers as a Multifunctional Bionanofiber Modality for Hydrogel Microspheres in a Micromolding-Based Fabrication-Conjugation Approach.","authors":"Alec K Zackin, Subhash Kalidindi, Hyunmin Yi","doi":"10.1021/acsabm.5c00632","DOIUrl":"https://doi.org/10.1021/acsabm.5c00632","url":null,"abstract":"Simple and tunable production of macroporous hydrogel microparticles for rapid protein quantification in a suspension array format remains a major challenge. We exploit biologically derived rigid nanofibers as a multifunctional modality in a robust micromolding method using a postfabrication bioconjugation approach to address this challenge. Specifically, chitin-core chitosan-sheath nanowhiskers (CSNW) with a tunable amine titer are prepared under mild deacetylation reaction conditions. Transmission electron microscopy, dynamic light scattering, and dynamic viscosity measurements show rigid bionanofibers with substantially lower viscosity compared to solubilized linear forms of chitosan and other biopolymers, suggesting improved handling and manufacturability. Fluorescent labeling studies on polyacrylamide-based microspheres fabricated via micromolding indicate stable and uniform incorporation of CSNW in hydrogel microspheres and the readily tunable chemical functionality of CSNW. Further, reliable fabrication using acrylate-modified CSNW as the primary cross-linker, along with selective and improved protein conjugation kinetics, attests to the macroporous network of the hydrogel microparticles and illustrates the multifunctionality of CSNW. We thus envision that our approach in harnessing potent bionanofibers and micromolding can be readily extended to produce a wide variety of multifaceted microscale materials with a multitude of desirable features with improved performances for applications such as rapid biosensing and biodiagnostics.","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144511240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Uptake Mechanism of Riboflavin-Functionalized Superparamagnetic Iron Oxide Nanoparticles in Triple-Negative Breast Cancer Cells. 核黄素功能化超顺磁性氧化铁纳米颗粒在三阴性乳腺癌细胞中的摄取机制。

IF 4.6

ACS Applied Bio Materials Pub Date : 2025-06-26 DOI: 10.1021/acsabm.5c00649

Sopon Nuchpun, Wid Mekseriwattana, Anna Solé-Porta, Bodee Nutho, Onrapak Reamtong, Patompon Wongtrakoongate, Anna Roig, Kanlaya Prapainop Katewongsa

{"title":"Uptake Mechanism of Riboflavin-Functionalized Superparamagnetic Iron Oxide Nanoparticles in Triple-Negative Breast Cancer Cells.","authors":"Sopon Nuchpun, Wid Mekseriwattana, Anna Solé-Porta, Bodee Nutho, Onrapak Reamtong, Patompon Wongtrakoongate, Anna Roig, Kanlaya Prapainop Katewongsa","doi":"10.1021/acsabm.5c00649","DOIUrl":"https://doi.org/10.1021/acsabm.5c00649","url":null,"abstract":"Superparamagnetic iron oxide nanoparticles (SPIONs), which are widely used as contrast agents in magnetic resonance imaging and as magnetic hyperthermia agents in cancer therapy, can be functionalized with biological molecules to enhance their specificity, stability, and cellular interaction. Riboflavin (Rf), a crucial biomolecule in cellular metabolism, is a potentially effective targeting moiety that can be selectively transported via riboflavin transporters (RFVTs), which are often overexpressed in cancer cells, including breast cancer cells. Here, we synthesize Rf-functionalized SPIONs (Rf-SPIONs) with high colloidal stability and stronger cellular interaction with breast cancer cells (MCF-7, and MDA-MB-231) than with normal breast cells (MCF-10A). Notably, the uptake is highest in triple-negative breast cancer cells (MDA-MB-231), a highly aggressive and treatment-resistant subtype. A mechanistic study revealed that RFVT is expressed in breast cancer cells and plays an important role in Rf-SPIONs uptake via the RFVT-mediated pathway. These findings identify riboflavin-functionalized nanoparticles as a promising platform for targeted delivery, diagnostic imaging, and cancer therapeutics. Rf-based nanomaterials could also pave the way for precision targeting of Rf-dependent metabolic pathways in cancer and other diseases.","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144504061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Design of Green-Synthesized Dy³⁺-Doped Iron Oxide Nanoparticle-Entrapped Liposomes for Synergistic Modulation of MRI Contrast, Magnetic Hyperthermia, and Combined Anticancer Efficacy. 绿色合成Dy3+掺杂氧化铁纳米颗粒包埋脂质体的设计，用于协同调节MRI造影剂，磁热疗和联合抗癌疗效。

IF 4.6

ACS Applied Bio Materials Pub Date : 2025-06-26 DOI: 10.1021/acsabm.5c00503

Poornima Govindharaj, Deepa Murugan, Somlee Gupta, Arunkumar Dhayalan, Barid Baran Lahiri, Arup Dasgupta, Sanjeevi Kannan

{"title":"Design of Green-Synthesized Dy3+-Doped Iron Oxide Nanoparticle-Entrapped Liposomes for Synergistic Modulation of MRI Contrast, Magnetic Hyperthermia, and Combined Anticancer Efficacy.","authors":"Poornima Govindharaj, Deepa Murugan, Somlee Gupta, Arunkumar Dhayalan, Barid Baran Lahiri, Arup Dasgupta, Sanjeevi Kannan","doi":"10.1021/acsabm.5c00503","DOIUrl":"https://doi.org/10.1021/acsabm.5c00503","url":null,"abstract":"Cancer treatment demands the development of multifunctional diagnostic tools and therapeutic agents with low toxicity and a high therapeutic index. The current work aimed to design multifunctional quercetin (QTN)-encapsulated Dy3+-doped magneto-liposomes as theranostic agents. Fe3O4 and Dy3+-doped Fe3O4 nanoparticles were synthesized with the aid of Punica granatum L fruit peel extract. The thin film hydration technique employed to encapsulate Dy3+-doped iron oxide nanoparticles (IONPs) in liposomes resulted in a small multilamellar vesicle size of ∼50 nm. The antioxidant capacity of QTN-encapsulated liposomes displayed improved efficacy and better radical oxygen scavenging (ROS) ability. The saturation magnetization initially increased upon Dy3+ addition, followed by a significant reduction at higher Dy3+ concentrations due to the formation of a mixed phase. Magnetic hyperthermia studies on Dy3+-doped magneto-liposomes revealed a superior heating efficiency of ∼95.0 ± 5.9 W/gFe at a biomedically relevant field-frequency range. Dy3+-doped magneto-liposomes increased both T1 and T2 contrast, especially with Dy3+ playing an effective role to shorten T2. The presence of Dy3+ in magneto-liposomes induced an enhanced X-ray attenuation of ∼22.7 HU. In vitro studies on MG-63 cell lines envisaged better efficacy against cancer cells (∼20%), while negligible cytotoxicity has been revealed from tests conducted on noncancerous HEK293 cells. The results clearly showed the multimodal theranostic applications of quercetin-loaded Dy3+-doped magneto-liposomes.","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144493095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0