ACS Applied Bio Materials最新文献

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Correction to "Standardized Method to Functionalize Plasma-Extracellular Vesicles via Copper-Free Click Chemistry for Targeted Drug Delivery Strategies". 更正 "通过无铜点击化学使血浆-细胞外囊泡功能化的标准化方法用于靶向给药策略"。
IF 4.6
ACS Applied Bio Materials Pub Date : 2024-07-12 DOI: 10.1021/acsabm.4c00890
Maria Chiara Ciferri, Silvia Bruno, Nicole Rosenwasser, Cansu Gorgun, Daniele Reverberi, Maria Cristina Gagliani, Katia Cortese, Cristina Grange, Benedetta Bussolati, Rodolfo Quarto, Roberta Tasso
{"title":"Correction to \"Standardized Method to Functionalize Plasma-Extracellular Vesicles via Copper-Free Click Chemistry for Targeted Drug Delivery Strategies\".","authors":"Maria Chiara Ciferri, Silvia Bruno, Nicole Rosenwasser, Cansu Gorgun, Daniele Reverberi, Maria Cristina Gagliani, Katia Cortese, Cristina Grange, Benedetta Bussolati, Rodolfo Quarto, Roberta Tasso","doi":"10.1021/acsabm.4c00890","DOIUrl":"https://doi.org/10.1021/acsabm.4c00890","url":null,"abstract":"","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":null,"pages":null},"PeriodicalIF":4.6,"publicationDate":"2024-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141588855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Syntheses and Applications of Coumarin-Derived Fluorescent Probes for Real-Time Monitoring of NAD(P)H Dynamics in Living Cells across Diverse Chemical Environments. 香豆素衍生荧光探针的合成与应用,用于实时监测活细胞在不同化学环境下的 NAD(P)H 动态。
IF 4.6
ACS Applied Bio Materials Pub Date : 2024-07-12 DOI: 10.1021/acsabm.4c00595
Adenike Mary Olowolagba, Micah Olamide Idowu, Dilka Liyana Arachchige, Omowunmi Rebecca Aworinde, Sushil K Dwivedi, Olivya Rose Graham, Thomas Werner, Rudy L Luck, Haiying Liu
{"title":"Syntheses and Applications of Coumarin-Derived Fluorescent Probes for Real-Time Monitoring of NAD(P)H Dynamics in Living Cells across Diverse Chemical Environments.","authors":"Adenike Mary Olowolagba, Micah Olamide Idowu, Dilka Liyana Arachchige, Omowunmi Rebecca Aworinde, Sushil K Dwivedi, Olivya Rose Graham, Thomas Werner, Rudy L Luck, Haiying Liu","doi":"10.1021/acsabm.4c00595","DOIUrl":"https://doi.org/10.1021/acsabm.4c00595","url":null,"abstract":"<p><p>Fluorescent probes play a crucial role in elucidating cellular processes, with NAD(P)H sensing being pivotal in understanding cellular metabolism and redox biology. Here, the development and characterization of three fluorescent probes, <b>A</b>, <b>B</b>, and <b>C</b>, based on the coumarin platform for monitoring of NAD(P)H levels in living cells are described. Probes <b>A</b> and <b>B</b> incorporate a coumarin-cyanine hybrid structure with vinyl and thiophene connection bridges to 3-quinolinium acceptors, respectively, while probe <b>C</b> introduces a dicyano moiety for replacement of the lactone carbonyl group of probe <b>A</b> which increases the reaction rate of the probe with NAD(P)H. Initially, all probes exhibit subdued fluorescence due to intramolecular charge transfer (ICT) quenching. However, upon hydride transfer by NAD(P)H, fluorescence activation is triggered through enhanced ICT. Theoretical calculations confirm that the electronic absorption changes upon the addition of hydride to originate from the quinoline moiety instead of the coumarin section and end up in the middle section, illustrating how the addition of hydride affects the nature of this absorption. Control and dose-response experiments provide conclusive evidence of probe <b>C</b>'s specificity and reliability in identifying intracellular NAD(P)H levels within HeLa cells. Furthermore, colocalization studies indicate probe <b>C</b>'s selective targeting of mitochondria. Investigation into metabolic substrates reveals the influence of glucose, maltose, pyruvate, lactate, acesulfame potassium, and aspartame on NAD(P)H levels, shedding light on cellular responses to nutrient availability and artificial sweeteners. Additionally, we explore the consequence of oxaliplatin on cellular NAD(P)H levels, revealing complex interplays between DNA damage repair, metabolic reprogramming, and enzyme activities. In vivo studies utilizing starved fruit fly larvae underscore probe <b>C</b>'s efficacy in monitoring NAD(P)H dynamics in response to external compounds. These findings highlight probe <b>C</b>'s utility as a versatile tool for investigating NAD(P)H signaling pathways in biomedical research contexts, offering insights into cellular metabolism, stress responses, and disease mechanisms.</p>","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":null,"pages":null},"PeriodicalIF":4.6,"publicationDate":"2024-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141597923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
3D Bioprinting with Visible Light Cross-Linkable Mucin-Hyaluronic Acid Composite Bioink for Lung Tissue Engineering. 利用可见光可交联粘蛋白-透明质酸复合生物墨水进行三维生物打印,实现肺组织工程。
IF 4.6
ACS Applied Bio Materials Pub Date : 2024-07-12 DOI: 10.1021/acsabm.4c00579
Sruthi C Sasikumar, Upashi Goswami, Ashok M Raichur
{"title":"3D Bioprinting with Visible Light Cross-Linkable Mucin-Hyaluronic Acid Composite Bioink for Lung Tissue Engineering.","authors":"Sruthi C Sasikumar, Upashi Goswami, Ashok M Raichur","doi":"10.1021/acsabm.4c00579","DOIUrl":"https://doi.org/10.1021/acsabm.4c00579","url":null,"abstract":"<p><p>3D printing can revolutionize personalized medicine by allowing cost-effective, customized tissue-engineering constructs. However, the limited availability and diversity of biopolymeric hydrogels restrict the variety and applications of bioinks. In this study, we introduce a composite bioink for 3D bioprinting, combining a photo-cross-linkable derivative of Mucin (Mu) called Methacrylated Mucin (MuMA) and Hyaluronic acid (HA). The less explored Mucin is responsible for the hydrogel nature of mucus and holds the potential to be used as a bioink material because of its plethora of features. HA, a crucial extracellular matrix component, is mucoadhesive and enhances ink viscosity and printability. Photo-cross-linking with 405 nm light stabilizes the printed scaffolds without damaging cells. Rheological tests reveal shear-thinning behavior, aiding cell protection during printing and improved MuMA bioink viscosity by adding HA. The printed structures exhibited porous behavior conducive to nutrient transport and cell migration. After 4 weeks in phosphate-buffered saline, the scaffolds retain 70% of their mass, highlighting stability. Biocompatibility tests with lung epithelial cells (L-132) confirm cell attachment and growth, suggesting suitability for lung tissue engineering. It is envisioned that the versatility of bioink could lead to significant advancements in lung tissue engineering and various other biomedical applications.</p>","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":null,"pages":null},"PeriodicalIF":4.6,"publicationDate":"2024-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141597889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Seaweed Superheroes: Cystoseira barbata-Incorporated Electrospun Fibers for Lead Ion Sequestration. 海藻超级英雄:用于铅离子封存的Cystoseira barbata-Incorporated Electrospun Fibers。
IF 4.6
ACS Applied Bio Materials Pub Date : 2024-07-11 DOI: 10.1021/acsabm.4c00550
Fatma Rabia Karaduman, Saniye Türk Çulha, Nesrin Horzum
{"title":"Seaweed Superheroes: <i>Cystoseira barbata</i>-Incorporated Electrospun Fibers for Lead Ion Sequestration.","authors":"Fatma Rabia Karaduman, Saniye Türk Çulha, Nesrin Horzum","doi":"10.1021/acsabm.4c00550","DOIUrl":"https://doi.org/10.1021/acsabm.4c00550","url":null,"abstract":"<p><p>The efficient removal of lead ions at low concentrations is paramount in combating the significant threat posed by water pollution resulting from industrial activities and population growth. In this study, electrospun <i>C. barbata</i>/PAN fibers were developed to efficiently remove lead(II) ions from water. The morphology, structure, and mechanical properties of the fibers were examined, highlighting that the augmentation of the surface area through the conversion of <i>C. barbata</i> into the polymer fibers facilitates increased metal bonding sites during sorption. <i>C. barbata</i>/PAN fibers exhibited superior characteristics, including higher surface area, smaller pore size, and increased pore volume, compared to powdered <i>C. barbata</i>. The effects of factors such as shaking time, algae percentage, sorbent amount, pH, metal concentration, and temperature on Pb(II) sorption were investigated by the batch method. At an initial ion concentration of 100 μg L<sup>-1</sup> and pH 4.0, <i>C. barbata</i> (5 wt %)/PAN fiber demonstrated a notable sorption efficiency of 89-90% (270 μg/g) after 60 min. The equilibrium data align with the Freundlich and Dubinin-Radushkevich isotherm models, whereas the pseudo-second-order kinetic model provides the most suitable description. The characterization of fibers after sorption revealed that carboxyl, hydroxyl, and sulfonyl groups play an active role in Pb(II) sorption.</p>","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":null,"pages":null},"PeriodicalIF":4.6,"publicationDate":"2024-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141588857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development of Drug-Loaded PCL@MOF Film Enclosed in a Photo Polymeric Container for Sustained Release. 在光聚合物容器中包裹药物负载 PCL@MOF 薄膜以实现持续释放的研究进展
IF 4.6
ACS Applied Bio Materials Pub Date : 2024-07-11 DOI: 10.1021/acsabm.4c00564
Shubhangi Shukla, Naveen Narasimhachar Joshi, Sachin Kadian, Roger J Narayan
{"title":"Development of Drug-Loaded PCL@MOF Film Enclosed in a Photo Polymeric Container for Sustained Release.","authors":"Shubhangi Shukla, Naveen Narasimhachar Joshi, Sachin Kadian, Roger J Narayan","doi":"10.1021/acsabm.4c00564","DOIUrl":"https://doi.org/10.1021/acsabm.4c00564","url":null,"abstract":"<p><p>The programmed fabrication of oral dosage forms is associated with several challenges such as controlled loading and disintegration. To optimize the drug payload, excipient breakdown, and site-specific sustained release of hydrophobic drug (sulfamethoxazole, SM), we propose the development of acrylate polymer tablets enclosed with drug-loaded polycaprolactone (PCL) films. The active pharmaceutical ingredient (API) is physisorbed into the porous iron (Fe)-based metal-organic framework (MOF) and later converted to tangible PCL films, which, upon folding, are incorporated into the acrylate polymer matrices (P1/P2/P3). X-ray powder diffraction (XRPD) analysis and scanning electron microscopy (SEM) micrographs confirmed the stability and homogeneous distribution of MOF within the 50 μm thick film. Adsorption-desorption measurements at ambient temperatures confirmed the decrease in the BET surface area of PCL films by 40%, which was ∼3.01 m/g, and pore volume from 30 to 9 nm. The decrease in adsorption and surface parameters could confirm the gradual accessibility of SM molecules once exposed to a degrading environment. Fourier transform infrared (FTIR) analyses of in vitro dissolution confirmed the presence of the drug in the MOF-PCL film-enclosed tablets and concluded the cumulative SM release at pH ∼ 8.2 which followed the order SM@Fe-MOF < P1/P2/P3 < PCL-SM@Fe-MOF < P1/PCL-SM@Fe-MOF < P3/PCL-SM@Fe-MOF. The results of the study indicate that the P3/PCL-SM@Fe-MOF assembly has potential use as a biomedical drug delivery alternative carrier for effective drug loading and stimuli-responsive flexible release to attain high bioavailability.</p>","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":null,"pages":null},"PeriodicalIF":4.6,"publicationDate":"2024-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141588856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Application of Natural Antibacterial Plants in the Extraction of Uranium from Seawater. 应用天然抗菌植物从海水中提取铀。
IF 4.6
ACS Applied Bio Materials Pub Date : 2024-07-10 DOI: 10.1021/acsabm.4c00605
Xue Zhang, Qianhong Gao, Yao Yuan, Dadong Shao
{"title":"Application of Natural Antibacterial Plants in the Extraction of Uranium from Seawater.","authors":"Xue Zhang, Qianhong Gao, Yao Yuan, Dadong Shao","doi":"10.1021/acsabm.4c00605","DOIUrl":"https://doi.org/10.1021/acsabm.4c00605","url":null,"abstract":"<p><p>Marine biofouling directly affects the performance and efficiency of uranium (U(VI)) extraction from seawater. Compared to traditional chemical methods, natural plant extracts are generally biodegradable and nontoxic, making them an environmentally friendly alternative to synthetic chemicals in solving the marine biofouling problem. The effectiveness of natural antibacterial plants (i.e., pine needle, peppermint, Acorus gramineus Soland, Cacumen platycladi, and wormwood) in solving the marine biofouling problem was evaluated in this work. Experimental results showed that natural antibacterial plants could kill <i>Vibrio alginolyticus</i> in solution and effectively solve the marine biofouling problem of U(VI) extraction. To improve the adsorption capacity of natural plants for U(VI) in seawater, poly(vinylphosphonic acid) (PVPA) was modified on natural antibacterial plant surfaces by irradiation grafting technology. PVPA and natural antibacterial plants work as active sites and base materials for the U(VI) extraction material, respectively. The recovery performance of PVPA/pine needle for U(VI) was preliminarily studied. Results show that the adsorption of U(VI) on PVPA/pine needle follows pseudo-second-order and Langmuir models, and the maximum adsorption capacity is 111 mg/g at 298 K and pH 8.2.</p>","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":null,"pages":null},"PeriodicalIF":4.6,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141582028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Utilizing Natural Materials in Electronic Devices: Inching Toward "Herbal Electronics". 在电子设备中利用天然材料:向 "草本电子学 "迈进。
IF 4.6
ACS Applied Bio Materials Pub Date : 2024-07-09 DOI: 10.1021/acsabm.4c00417
Soumya Tiwari, Tanushree Ghosh, Suchita Kandpal, Shailendra Saxena, Rajesh Kumar, Rajiv Prakash, Anjali Chaudhary
{"title":"Utilizing Natural Materials in Electronic Devices: Inching Toward \"Herbal Electronics\".","authors":"Soumya Tiwari, Tanushree Ghosh, Suchita Kandpal, Shailendra Saxena, Rajesh Kumar, Rajiv Prakash, Anjali Chaudhary","doi":"10.1021/acsabm.4c00417","DOIUrl":"https://doi.org/10.1021/acsabm.4c00417","url":null,"abstract":"<p><p>Sustainable development is the primary key to address global energy challenges. Though the scientific community is engaged in developing efficient ways to not only maximize energy production from natural resources like sun, wind, water, etc. but also to make all the electronic gadgets power efficient, despite all this, the materials used in most of the electronic devices are largely produced using various materials processing techniques and semiconductors, polymers, dielectrics, etc. which again increases the burden on energy and in turn affects the environment. While addressing these challenges, it is very important to explore the possibility to directly, or with minimum processing, utilize the potential of natural resources in the development of electronic devices. Recent articles are focused on the development of herbal electronic devices that essentially implement natural resources, like plants, leaves, etc., either in their raw or extracted form in the device assembly. This review encompasses the recent research developments around herbal electronic devices. Furthermore, herbal electronics has been discussed for several functional applications including electrochromism, energy storage, memresistor, LED, solar cell, water purification, pressure sensor, etc. Moreover, advantages, disadvantages, and challenges encountered in the realization of \"herbal electronics\" have been discussed at length.</p>","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":null,"pages":null},"PeriodicalIF":4.6,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141561859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Zinc Oxide/Carbon Material-Embedded Supramolecular Drug Delivery System with Photoswitching Properties for Highly Selective and Effective Chemotherapy. 具有光开关特性的氧化锌/碳材料嵌入式超分子给药系统,用于高选择性和有效的化疗。
IF 4.6
ACS Applied Bio Materials Pub Date : 2024-07-09 DOI: 10.1021/acsabm.4c00638
Fasih Bintang Ilhami, Munasir, Noto Susanto Gultom, Chih-Chia Cheng
{"title":"Zinc Oxide/Carbon Material-Embedded Supramolecular Drug Delivery System with Photoswitching Properties for Highly Selective and Effective Chemotherapy.","authors":"Fasih Bintang Ilhami, Munasir, Noto Susanto Gultom, Chih-Chia Cheng","doi":"10.1021/acsabm.4c00638","DOIUrl":"https://doi.org/10.1021/acsabm.4c00638","url":null,"abstract":"<p><p>Phototherapy has become a hopeful procedure for the treatment of cancer. Nevertheless, the straightforward creation of a theranostic system that can achieve both tumor localization and production of oxygen species is greatly desired yet remains a challenging endeavor. In this study, we synthesized spherical nanostructures by decorating zinc oxide (ZnO) with peanut shell-based carbon (PNS-C) in an aqueous solution. The PNS-C-decorated ZnO (ZnO/PNS-C)-embedded supramolecular system exhibited spontaneous self-assembly. The nanogels that are produced have several desirable characteristics, including exceptional resistance to degradation by light, highly stable nanostructures that form spontaneously in biological environments, outstanding ability to prevent the destruction of red blood cells, and a high level of sensitivity to changes in pH and light. Under light irradiation, the addition of ZnO/PNS-C-incorporated supramolecular provided high reactive oxygen species production. Moreover, in vitro cellular assays demonstrated ZnO/PNS-C-incorporated supramolecular exhibited highly selective and induced phototoxicity into cancer cells and no effect on the viability of normal cells both before and after irradiation. Overall, the ZnO/PNS-C-incorporated supramolecular system has the potential to stimulate advancements in phototherapy by utilizing highly tumor-selective therapeutic molecules. This can lead to a more effective targeted therapy for cancers.</p>","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":null,"pages":null},"PeriodicalIF":4.6,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141557357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Redox-Reversible Switch of DNA Hydrogen Bonding and Structure. DNA 氢键和结构的氧化还原可逆开关
IF 4.6
ACS Applied Bio Materials Pub Date : 2024-07-08 DOI: 10.1021/acsabm.4c00529
Ayman Alawneh, Ashan P Wettasinghe, Reema McMullen, Melodee O Seifi, Ivan Breton, Jason D Slinker, Robert D Kuchta
{"title":"A Redox-Reversible Switch of DNA Hydrogen Bonding and Structure.","authors":"Ayman Alawneh, Ashan P Wettasinghe, Reema McMullen, Melodee O Seifi, Ivan Breton, Jason D Slinker, Robert D Kuchta","doi":"10.1021/acsabm.4c00529","DOIUrl":"https://doi.org/10.1021/acsabm.4c00529","url":null,"abstract":"<p><p>Modulating molecular structure and function at the nanoscale drives innovation across wide-ranging technologies. Electrical control of the bonding of individual DNA base pairs endows DNA with precise nanoscale structural reconfigurability, benefiting efforts in DNA origami and actuation. Here, alloxazine DNA base surrogates were synthesized and incorporated into DNA duplexes to function as a redox-active switch of hydrogen bonding. Circular dichroism (CD) revealed that 24-mer DNA duplexes containing one or two alloxazines exhibited CD spectra and melting transitions similar to DNA with only canonical bases, indicating that the constructs adopt a B-form conformation. However, duplexes were not formed when four or more alloxazines were incorporated into a 24-mer strand. Thiolated duplexes incorporating alloxazines were self-assembled onto multiplexed gold electrodes and probed electrochemically. Square-wave voltammetry (SWV) revealed a substantial reduction peak centered at -0.272 V vs Ag/AgCl reference. Alternating between alloxazine oxidizing and reducing conditions modulated the SWV peak in a manner consistent with the formation and loss of hydrogen bonding, which disrupts the base pair stacking and redox efficiency of the DNA construct. These alternating signals support the assertion that alloxazine can function as a redox-active switch of hydrogen bonding, useful in controlling DNA and bioinspired assemblies.</p>","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":null,"pages":null},"PeriodicalIF":4.6,"publicationDate":"2024-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141557359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Eco-Friendly Biomemristive Nonvolatile Memory: Harnessing Organic Waste for Sustainable Technology. 生态友好型生物膜非易失性存储器:利用有机废物开发可持续技术。
IF 4.6
ACS Applied Bio Materials Pub Date : 2024-07-08 DOI: 10.1021/acsabm.4c00085
Arpita Roy, Karuna Kumari, Shantanu Majumder, Soumya J Ray
{"title":"Eco-Friendly Biomemristive Nonvolatile Memory: Harnessing Organic Waste for Sustainable Technology.","authors":"Arpita Roy, Karuna Kumari, Shantanu Majumder, Soumya J Ray","doi":"10.1021/acsabm.4c00085","DOIUrl":"https://doi.org/10.1021/acsabm.4c00085","url":null,"abstract":"<p><p>Organic material-based bioelectronic nonvolatile memory devices have recently received a lot of attention due to their environmental compatibility, simple fabrication recipe, preferred scalability, low cost, low power consumption, and numerous additional advantages. Resistive random-access memory (RRAM) devices work on the principle of resistive switching, which has the potential for applications in memory storage and neuromorphic computing. Here, natural organically grown orange peel was used to extract biocompatible pectin to design a resistive switching-based memory device of the structure Ag/Pectin/Indium tin oxide (ITO), and the behavior was studied between a temperature range of 10K and 300K. The microscopic characterization revealed the texture of the surface and thickness of the layers. The memristive current-voltage characteristics performed over 1000 consecutive cycles of repeated switching revealed sustainable bipolar resistive switching behavior with a high ON/OFF ratio. The underlying principle of Resistive Switching behavior is based on the formation of conductive filaments between the electrodes, which is explained in this work. Further, we have also designed a 2 × 2 crossbar array of RRAM devices to demonstrate various logic circuit operations useful for neuromorphic computing. The robust switching characteristics suggest possible uses of such devices for the design of ecofriendly bioelectronic memory applications and in-memory computing.</p>","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":null,"pages":null},"PeriodicalIF":4.6,"publicationDate":"2024-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141557358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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