ACS Applied Bio Materials最新文献

{"title":"CuBTTri MOF-Functionalized Hyaluronic Acid-Polydopamine Composite Coating for Selective Endothelialization and Enhanced Hemocompatibility on Polydimethylsiloxane Surfaces.","authors":"Aiqing Li, Jun Sun, Denghai Sheng, Shengen Gu, Mengying Zhan, Xiaoli Liu, Hong Chen","doi":"10.1021/acsabm.5c00780","DOIUrl":"https://doi.org/10.1021/acsabm.5c00780","url":null,"abstract":"<p><p>Blood-contacting materials are frequently challenged by endothelial damage, thrombosis, and intimal hyperplasia, significantly limiting their long-term efficacy. To mitigate these issues, a composite coating was developed by integrating nitric oxide (NO)-releasing CuBTTri with hyaluronic acid (HA) on a polydimethylsiloxane surface. To combine the cell adhesion property of polydopamine coatings, the hydrophilic and antifouling properties of HA, and the ability of CuBTTri to catalyze NO release, a polydopamine-polyethylenimine layer was deposited to enhance surface adhesion, followed by the covalent attachment of CuBTTri-loaded hyaluronic acid, forming hyaluronic acid-polydopamine composite coatings (PHMn). Among these, the PHM2 coating (200 μg/mL CuBTTri, obtained by dispersing 1 mg CuBTTri in 5 mL HA solution) demonstrated superior performance, efficiently catalyzing NO release from endogenous donors. This process selectively inhibited smooth muscle cell (HUVSMC) adhesion and proliferation while fostering endothelial cell (HUVEC) growth, achieving a HUVEC-to-HUVSMC density ratio of approximately 1.9. Furthermore, HUVECs on PHM2 exhibited high viability (∼97%) and increased CD31 expression, reflecting favorable endothelialization. The coating also displayed remarkable hemocompatibility, as evidenced by extended plasma recalcification time and a reduced hemolysis rate. The NO-releasing capability of CuBTTri, in conjunction with the hydrophilic and antifouling characteristics of hyaluronic acid, constitutes an effective strategy for fabricating blood-contacting materials with selective endothelialization and sustained hemocompatibility.</p>","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144697060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of Polysaccharide-Stabilized Selenium Disulfide Nanoparticles for Enhanced Antioxidant and Antimicrobial Applications in Dermatology.","authors":"Shiqiong Wang, Yu Zhong, Jiayi Huang, Yidan Ma, Shanyu Li, Yufeng Zeng, Haoran Fan, Qiuxing He","doi":"10.1021/acsabm.5c00719","DOIUrl":"https://doi.org/10.1021/acsabm.5c00719","url":null,"abstract":"<p><p>Selenium disulfide (SeS₂) is a promising therapeutic agent for dermatological conditions, including dandruff and pruritus, but its clinical application is limited by poor solubility and stability. To address these challenges, we developed selenium disulfide nanoparticles stabilized by polysaccharides from <i>Radix saposhnikoviae</i> (SPS-SeS₂NPs) for enhanced aqueous dispersion and evaluated their antioxidant properties, antibacterial efficacy, and dermal safety. The synthesized SPS-SeS₂NPs exhibited an average hydrodynamic diameter of 115.54 ± 2.3 nm, with a true particle size of approximately 60 nm, as confirmed by electron microscopy. The nanoparticles demonstrated excellent stability, with minimal changes in particle size after 28 days of storage at 4 °C. Furthermore, SPS-SeS₂NPs displayed significant antioxidant activity and potent antibacterial effects against <i>Malassezia furfur</i> and <i>Staphylococcus epidermidis</i>, two pathogens commonly associated with skin disorders. Importantly, the nanoparticles showed no significant irritant effects on the skin, indicating their potential for safe dermatological use. This study provides a foundation for developing SPS-SeS₂NPs as a novel nanomaterial-based therapeutic strategy for treating skin infections and oxidative stress-related dermatological conditions.</p>","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144688290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quaternized Chitosan-Coated Nano-MOFs as Antigen Nanocarriers with Enhanced Stability and Immunogenicity.","authors":"Haiquan Gu, Jianxu Zhang, Shiyao Xu, Yujie Yang, Yang Li, Yubiao Xie, Zhuo Hao, Nan Li, Yawei Li, Wenhe Zhu, Yafeng Li, Kai Wang, Qianxue Li","doi":"10.1021/acsabm.5c00618","DOIUrl":"https://doi.org/10.1021/acsabm.5c00618","url":null,"abstract":"<p><p>Vaccines are among the greatest achievements of modern medicine, and have saved countless lives. Subunit vaccines are vaccines made from specific parts (subunits) of a pathogen. Compared other types of vaccines, such as inactivated and live-attenuated vaccines, they are generally safer and more suitable for individuals with weakened immune systems. However, their immunogenicity is typically lower, which is why adjuvants are often required to enhance the immune response. Metal-organic frameworks (MOFs), exemplified by zeolitic imidazole framework-90 (ZIF-90), represent an emerging class of porous materials noted for their substantial pore dimensions, freely adjustable particle sizes, excellent chemical stability, biocompatibility, and pH sensitivity of coordination framework dissociation. These features present significant potential for development in the field of vaccine delivery carriers. Chitosan quaternary ammonium salts have good biosafety and can improve immunogenicity. This study successfully encapsulated ovalbumin (OVA) within ZIF-90 using a one-step stirring method to form OVA@ZIF-90 (ZO). Subsequently, the quaternary ammonium salt of chitosan was added to modify ZO through adsorption, resulting in ZIF-90@OVA@HACC (ZOH), which increased the stability and immunogenicity of OVA. Compared with free OVA, ZO and ZOH enhanced the immunogenicity of OVA, promoting the cellular uptake of antigens and escape from lysosomes, activating dendritic cells, stimulating the secretion of cytokines, forming an antigen reservoir to encourage the production of antibodies, and activating CD4⁺ T and CD8⁺ T cells to increase the generation of memory T cells. This study underscores the importance of ZIF-90 and chitosan quaternary ammonium salts in improving the stability and immunogenicity of antigens, which has considerable reference value for the development of subsequent immunizing vaccines.</p>","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144688291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"pH-Responsive Nanosuspension Based on an Orthoester for Synergistic Chemodynamic and Photothermal Therapy in Localized Cancer Treatment.","authors":"Junjie Hu, Chi Zhang, Hao Xu, Yingda Wan, Xin Wang, Rupei Tang","doi":"10.1021/acsabm.5c00578","DOIUrl":"10.1021/acsabm.5c00578","url":null,"abstract":"<p><p>This study aims to develop a pH-responsive nanosuspension for localized cancer therapy by integrating photothermal therapy (PTT) and chemodynamic therapy (CDT). Initially, we synthesized a compound containing two five-membered cyclic orthoester bonds (OE) as a liquid pharmaceutical excipient. This OE was subsequently coloaded with the photothermal agent indocyanine green (ICG) and iron oxide nanoparticles (Fe₃O₄), forming a stable nanosuspension (OE/ICG/Fe₃O₄). OE exhibits acid-sensitive degradation, enabling controlled drug release in the tumor microenvironment. The Fe₃O₄ nanoparticles can induce the generation of reactive oxygen species (ROS) through the Fenton reaction, which synergizes effectively with the photothermal effect of ICG. Additionally, the OE/ICG/Fe₃O₄ formulation prolongs drug retention in tumor tissues and enhances drug penetration. Furthermore, the formulation induces immune modulation via Fe₃O₄, thereby enhancing the overall therapeutic efficacy. Under 808 nm near-infrared laser irradiation, a tumor suppression rate of 84.6% was achieved through the combination of photothermal and chemodynamic therapies and immunotherapy. This study highlights the potential of OE-based nanosuspensions for localized cancer treatment, offering a multifunctional strategy to improve treatment outcomes while minimizing systemic toxicity.</p>","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":" ","pages":"5854-5868"},"PeriodicalIF":4.6,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144264747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Indolo-[2,3-<i>b</i>]quinoxaline: A Core for the Stabilization of Room Temperature Liquid Crystalline Self-Assembly, Aggregation-Induced Emission, and Bioimaging Applications.","authors":"Rahul Ahmed, Vinay Sharma, Shweta Thakar, Paresh Kumar Behera, Praveen Kandpal, Doddamane Sreenivasamurthy Shankar Rao, Achalkumar Ammathnadu Sudhakar","doi":"10.1021/acsabm.5c00762","DOIUrl":"10.1021/acsabm.5c00762","url":null,"abstract":"<p><p>Aggregation-induced emission (AIE) is a significant property that enables the translation of the fluorescence emission of chromophores in solution to the solid state. In recent years, the development of AIE-active liquid crystals has garnered considerable interest. In this context, we introduce a class of indolo[2,3-<i>b</i>]quinoxaline (<b>IQ</b>) based luminescent liquid crystals, demonstrating excellent solubility and thermal stability. The efficient space-filling interactions in compounds with seven and ten peripheral <i>N</i>-alkoxy chains (<b>IQ3</b> and <b>IQ4</b>) stabilize a columnar liquid crystalline phase at room temperature. Interestingly, these compounds exhibit tunable luminescence and liquid crystalline self-assembly in addition to technologically important AIE properties, in contrast to the commonly observed aggregation-caused quenching (ACQ) in the case of discotic liquid crystals (DLC). Compound <b>IQ4</b> was selected for bioimaging studies due to its robust fluorescence behavior and AIE-active properties, facilitating uniform staining throughout the nematode cell body. Under aggregated conditions, visualization of the nematode body was significantly enhanced. Additionally, <b>IQ4</b> was explored as a fluorescent probe for staining MCF7 cancer cells, where cellular uptake and localization studies revealed its exceptional fluorescence intensity and remarkable ability to target and visualize cancer cells. Its ability to stain individual cancer cells enabled high-contrast imaging with striking fluorescence signals, while its precise localization illuminated distinct cellular structures, thereby enhancing the resolution of bioimaging.</p>","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":" ","pages":"6278-6290"},"PeriodicalIF":4.6,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144281651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Highly Selective Electrochemical Detection of Vitamin K1 (Phylloquinone) in Simulated Blood Serum Using Bimetallic Cu/Ni-MOF Decorated CNT Composite on Nickel Foam.","authors":"Manaswini Ravipati, Simran Moorjani, Divyasri Ramasamy, Sushmee Badhulika","doi":"10.1021/acsabm.5c00325","DOIUrl":"10.1021/acsabm.5c00325","url":null,"abstract":"<p><p>Phylloquinone (Vitamin K) is a vital vitamin for humans since it plays a critical role in blood clotting by enabling the synthesis of proteins required for coagulation. The physiological and therapeutic significance of Vitamin K (VIT K) necessitates the development of precise techniques for its accurate quantification. In this study, we report the electrochemical detection of Vitamin K in simulated blood serum using a bimetallic CuNi-MOF/CNT (copper/nickel metal-organic framework decorated carbon nanotube) composite on nickel foam (NF) via differential pulse voltammetry (DPV). The CuNi-MOF/CNT composite is synthesized using a one-pot solvothermal method, embedding Cu/Ni-MOF with CNTs to form a porous structure with enhanced electrical properties. Scanning electron microscopy (SEM) reveals the presence of bimetallic MOFs with granular and cubical morphologies along with well-dispersed CNT structures; Fourier transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD) analyses confirm functional group interactions and crystallinity of the CuNi-MOF/CNT composite. The CuNi-MOF/CNT composite, drop-casted (0.5 wt %) on a Ni foam electrode, exhibits excellent electrochemical performance with a wide linear detection range from 30 nM to 10 μM, a high sensitivity of 1.97 mA μM^-1 cm^-2, and a low detection limit (LOD) of 0.03 nM. The sensor displays commendable selectivity, as it maintains its activity even when it is subjected to potentially interfering species like DA, AA, UA, and H₂O₂. The composite demonstrates excellent stability and reproducibility (tested using four electrodes). The superior performance of the sensor can be ascribed to the synergistic effect of the bimetallic Cu/Ni-MOF and CNTs, which enhances electron transfer, increases surface area, and improves conductivity. The unique structural and electronic properties of the composite contribute to the enhanced electrocatalytic activity, demonstrating its potential for advanced biosensing applications in clinical diagnostics and next-generation wearable health monitoring systems.</p>","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":" ","pages":"5670-5679"},"PeriodicalIF":4.6,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144292976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tunable Drug Release through Varying Drug Affinities for Ocular Chronic Disease.","authors":"Hyeonah Lee, Serim Byun, Moonyoung Kim, Hyeokjung Kim, Hyeran Noh","doi":"10.1021/acsabm.5c00425","DOIUrl":"10.1021/acsabm.5c00425","url":null,"abstract":"<p><p>Effective drug delivery is critical for the management of chronic diseases such as glaucoma, where sustained therapeutic levels can significantly enhance treatment outcomes. In this study, we present a Particles-on-a-Gel (PoG) system that leverages differential nanocarrier affinities to modulate drug release kinetics. By integrating poly(N-isopropylacrylamide) nanogels (pNIPAM) and silver nanoparticles (AgNPs), the PoG platform enables both controlled initial release and prolonged drug delivery. Isothermal titration calorimetry (ITC) was employed to quantitatively characterize the thermodynamic interactions between timolol maleate and the nanocarriers, revealing distinct binding modalities─hydrophobic interactions with pNIPAM and chemically driven binding with AgNPs. These findings underscore the role of thermodynamic tuning in optimizing drug-carrier interactions to enhance release profiles and retention. Furthermore, incorporation of the PoG system into a contact lens-based drug delivery platform demonstrated its translational potential, maintaining optical transparency while enabling sustained drug release. Overall, this work highlights the promise of thermodynamically guided nanocarrier design in developing patient-centric drug delivery systems for chronic disease management.</p>","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":" ","pages":"5732-5742"},"PeriodicalIF":4.6,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144323799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ophicalcitum-Inspired Microspheres as a Topical Hemostatic Agent.","authors":"Yang Liu, Fen Wan, Ruoyu Ba, Yimin Han, Ting Geng, Beihua Bao, Weifeng Yao, Wei-Wei Xiong, Li Zhang, Fang-Fang Cheng","doi":"10.1021/acsabm.5c00925","DOIUrl":"10.1021/acsabm.5c00925","url":null,"abstract":"<p><p>Ophicalcitum, as an oral mineral in traditional Chinese medicine, has a long history of therapeutic use in hemostasis, and its main component is calcium carbonate, which has good biosafety, excellent structural properties, and low cost. Inspired by it, calcium carbonate microspheres with different particle sizes were synthesized using ethylene glycol and ultrapure water as solvents. Furthermore, luteolin was loaded onto calcium carbonate microspheres to prepare multifunctional hemostatic materials with healing-promoting effects. Experimental results have shown that calcium carbonate microspheres had excellent hemostatic properties without hemolytic, cytotoxic, and metabolic toxic effects and their hemostatic properties were independent of particle sizes. In addition, luteolin loaded on calcium carbonate microspheres promoted skin healing, indicating that these calcium carbonate microspheres were potential hemostatic materials.</p>","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":" ","pages":"6426-6438"},"PeriodicalIF":4.6,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144323796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"NIR-Responsive Carbon Dots Functionalized with AS1411 Aptamer: A Dual-Mode Approach to Enhanced Photothermal and Photodynamic Therapy.","authors":"Kanchan Negi, Sushmita Patra, Ashok Kumar, Sujit Kumar Bhutia, Sumanta Kumar Sahu","doi":"10.1021/acsabm.5c00775","DOIUrl":"10.1021/acsabm.5c00775","url":null,"abstract":"<p><p>Recent advancements in light-based treatments, including photodynamic therapy (PDT) and photothermal therapy (PTT), present promising alternatives to conventional cancer treatments. Moreover, combination therapy employing multiple therapeutic approaches has become a cornerstone of modern oncology, aiming to enhance treatment efficacy and overcome resistance mechanisms. This study presents an approach to enhance the effectiveness of PDT and PTT in cancer treatment by synthesizing carbon dots from the organic dye IR-820 and citric acid. The IR820-based carbon dots (IRCDs) were synthesized through a one-step hydrothermal process, inheriting the near-infrared fluorescence properties of IR-820. To facilitate targeted delivery to cancer cells, AS1411 aptamers were conjugated to the surface of IRCDs via EDC/NHS chemistry, forming IRCDs@AS1411. This transformation of IR-820 into carbon dots not only preserved its NIR fluorescence and therapeutic functionalities but also significantly enhanced the chemical stability, photostability, and resistance to photobleaching of the resulting nanomaterials. Notably, IRCDs@AS1411 exhibited a photothermal conversion efficiency approximately 35% higher than that of free IR-820. In vitro experiments demonstrated that IRCDs@AS1411 served as effective agents for bioimaging, PDT, and PTT, overcoming the limitations of traditional organic dyes and efficiently eradicating tumor cells under 808 nm laser irradiation. These findings suggest that IRCDs@AS1411 hold significant promise for advanced cancer therapy and provide a versatile platform for developing other functional nanomaterials.</p>","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":" ","pages":"6305-6315"},"PeriodicalIF":4.6,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144574333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bimetallic Fe, Ru-doped Zn-Centered Organic Framework Mesoporous Carbon for Single-Wavelength Near-Infrared-Induced Photothermal/Photodynamic Synergistic Therapy.","authors":"Jingzhen Cao, Qian Lu, Zhengyang Liu, Shu Xing, Xinhua Shi, Xian Zhang, Zeyuan Sun, Sheng Gao","doi":"10.1021/acsabm.5c00872","DOIUrl":"10.1021/acsabm.5c00872","url":null,"abstract":"<p><p>Single-wavelength synergistic photothermal/photodynamic therapy (PTT/PDT) is gradually emerging in cancer treatment, with the key limitation being the photosensitizer. In this work, a metal-organic framework-derived mesoporous carbon with zinc centers and doped with iron and ruthenium, exhibiting porphyrin-like properties (denoted as Fe₅₀-Ru_<i>y</i>-ZIF₉₀₀), was successfully synthesized via a green, simple, and mild hydrothermal reaction. The effects of various Fe:Ru doping ratios on the morphology, structure, and PTT/PDT of Fe₅₀-Ru_<i>y</i>-ZIF₉₀₀ were studied. We found that bimetallic doping significantly improved both the PTT and PDT performance of the materials. Especially for Fe₅₀-Ru₁₀-ZIF, it demonstrated the best PTT/PDT performance under single-wavelength near-infrared (808 nm) light irradiation in a hydrophilic environment. Its photothermal conversion efficiency (η) can be as high as 57.66%, and the singlet oxygen (¹O₂) quantum yield (Φ) is about 0.0053, comparable to that of indocyanine green (ICG). This enhancement may be attributed to the synergistic effect between homologous elements of the same family. In addition, under single-wavelength near-infrared laser irradiation, Fe₅₀-Ru₁₀-ZIF₉₀₀ can generate a substantial amount of ¹O₂ in living tumor cells and synergistically induce extensive necrosis/apoptosis of tumor cells. All of these findings indicate that Fe₅₀-Ru₁₀-ZIF₉₀₀ can serve as an excellent photosensitizer, bringing greater feasibility to the realization of single-wavelength dual-mode PTT/PDT treatment.</p>","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":" ","pages":"6388-6396"},"PeriodicalIF":4.6,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144606768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}