化学•材料最新文献

{"title":"Retraction notice to: \"A fluorescent signal \"removal\" sensor via duplex-specific nuclease-aided cleavage for miRNA detection in flow cytometry\" [Colloids Surf. B: Biointerfaces. 185 (2020), 110570].","authors":"Weipan Peng, Yiwen Huang, Qian Zhao, Guowei Lian, Minghui Chen, Jiafang Piao, Xiaoqun Gong, Jin Chang","doi":"10.1016/j.colsurfb.2026.116208","DOIUrl":"10.1016/j.colsurfb.2026.116208","url":null,"abstract":"","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":" ","pages":"116208"},"PeriodicalIF":5.9,"publicationDate":"2027-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149101842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PHANTOM platform integrating photothermal PCR and swCNT-FET for rapid molecular diagnostics.","authors":"Jingrui Wu, Da Eun Oh, Hyunju Cho, Jiwoong Son, Hua Mi, Hong-Seog Park, Yung-Kang Peng, Jwa-Min Nam, Tae Hyun Kim, Jung-Hoon Lee","doi":"10.1016/j.bios.2026.119088","DOIUrl":"10.1016/j.bios.2026.119088","url":null,"abstract":"<p><p>Plasmonic photothermal polymerase chain reaction (PPT-PCR) is a nucleic acid amplification technique that utilizes the localized surface plasmon resonance effect of plasmonic nanomaterials under the irradiation of light with specific wavelengths to achieve rapid thermal cycling. PPT-PCR is considered as a next-generation PCR technique due to the potential to be applied to the development of point-of-care diagnostics and the fast, sensitive and accurate detection performance. In this study, we present PHANTOM, a proof-of-concept system that functionally integrates plasmonic photothermal PCR, magnetic nanoparticle removal, and swCNT-FET-based label-free electrical readout for rapid molecular diagnostics. The swCNT-FET sensor exhibits high sensitivity, capable of detecting low concentrations of target nucleic acids within minutes after PPT-PCR amplification. Besides, to improve the specificity of the assay, we introduce a hairpin structured primer to generate amplicons with an external single-strand tail that can hybridize with probes modified on the swCNT-FET sensor. With this design, an estimated limit of detection of 1.5 aM (experimentally validated down to 10 aM) was achieved within 20 min.</p>","PeriodicalId":259,"journal":{"name":"Biosensors and Bioelectronics","volume":"312 ","pages":"119088"},"PeriodicalIF":11.8,"publicationDate":"2026-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148676614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intermolecular Dearomative Alkylation–Cyclization Cascade of β-Aryltryptophols: Diastereoselective Access to Furoindolines with Three Contiguous Stereocenters","authors":"Upasana Deka,Sajal Kumar Das","doi":"10.1021/acs.joc.6c02187","DOIUrl":"https://doi.org/10.1021/acs.joc.6c02187","url":null,"abstract":"Intermolecular dearomative C3-alkylation of indoles bearing an adjacent, sterically encumbered stereocenter presents a dual challenge: overcoming substantial steric hindrance to achieve efficient reactivity and attaining high facial diastereoselectivity. Herein, we report a NaOtBu/Et3B-promoted intermolecular dearomative alkylation–cyclization cascade of β-aryltryptophols that addresses both challenges, affording furoindolines bearing three contiguous stereogenic centers in yields of up to 88%, with the endo-diastereomers consistently obtained as the major products (up to 11.2:1 endo/exo d.r.). The method was demonstrated across 36 examples, incorporating allylic, benzylic, and propargyl bromides as well as methyl iodide, and accommodating diverse electronic variations on both the indole nucleus and the pendant aryl ring of the β-aryltryptophol substrates. An enantioenriched substrate underwent the reaction without detectable racemization (>99:1 e.r.), indicating retention of the pre-existing stereocenter and its stereochemical relay to the newly formed stereocenters. An α-aryltryptophol, in which the stereogenic center is one atom farther from the indole C3 position, also underwent the cascade process, although the corresponding exo-diastereomers were isolated as the major products (up to 5.2:1 exo/endo d.r.).","PeriodicalId":57,"journal":{"name":"Journal of Organic Chemistry","volume":"9 1","pages":""},"PeriodicalIF":4.354,"publicationDate":"2026-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149374803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of the Reproducibility of Experimental Results in Aqueous Alkaline Media Using Pt Electrodes","authors":"Niusha Mouchani,Derek Esau,Gregory Jerkiewicz","doi":"10.1021/acs.jpcc.6c06513","DOIUrl":"https://doi.org/10.1021/acs.jpcc.6c06513","url":null,"abstract":"Research in interfacial electrochemistry and electrocatalysis requires establishing standard experimental procedures and conditions that ensure reproducibility and reliability of results. While standard procedures for experimental research employing Pt electrodes in aqueous acidic solutions were established ca. 50 years ago, similar benchmarks for aqueous alkaline media do not exist. In this contribution, cyclic voltammetry (CV) experiments are performed in the 0.05–1.40 V range using polycrystalline and monocrystalline platinum electrodes (Pt(poly) and Pt(POSSC)) in 0.50 M aqueous H2SO4 (a reference electrolyte solution) and 0.10 M aqueous NaOH (a studied electrolyte solution) to verify the systems’ cleanliness and to determine the electrodes’ electrochemically active surface area (Aecsa). Afterward, chronoamperometry (CA) measurements are conducted by holding the applied potential at 0.50 V for various holding times in the 30–1,800 s range, and then Aecsa is re-evaluated by CV experiments. The results demonstrate that unavoidable contamination, present even in the highest purity chemicals and water, adsorbs on the surface of the Pt electrodes and reduces their Aecsa. The reduction in Aecsa increases with increasing the holding time in CA measurements. Energy-dispersive X-ray (EDS) spectroscopy and X-ray photoelectron spectroscopy (XPS) analyses of the Pt(poly) and Pt(POSSC) electrodes reveal the presence of C and O-containing compounds in the case of aqueous H2SO4 solution and C, O, and Pb compounds in the case of aqueous NaOH solution. The results demonstrate the complementarity of electrochemical and surface science methods in assessing the cleanliness of electrode materials and highlight the need for rigorous experimental protocols that ensure reproducibility and reliability of experimental results.","PeriodicalId":61,"journal":{"name":"The Journal of Physical Chemistry C","volume":"19 1","pages":""},"PeriodicalIF":4.126,"publicationDate":"2026-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149374900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multi-Barrel Nanopipets as a Model System for Quantifying Interpore Interactions and Superadditive Transport","authors":"Anthony Dougman Cho,Claudia Evodie Puspa Dewi,Ethan Cao,Kelly L. Vernon,Cody W. Leasor,Tilman E. Schäffer,Lane A. Baker,Zuzanna S. Siwy","doi":"10.1021/acs.jpclett.6c02789","DOIUrl":"https://doi.org/10.1021/acs.jpclett.6c02789","url":null,"abstract":"Developing advanced neuromorphic ionic devices requires a quantitative understanding of how neighboring nanopores interact within arrays. Crosstalk between adjacent pores is especially important because overlapping depletion zones can suppress current and cause the current through a parallel-pore array to be lower than the sum of currents through isolated pores. Here, using dual-barrel nanopipets as a model two-pore array, we show that interacting barrels connected in parallel can also produce superadditive transport, where the combined current exceeds the sum of currents through two independently measured barrels. Conductance enhancement is observed when closely spaced barrels carry opposite surface charges, with one barrel negatively charged and the other positively charged. Poisson–Nernst–Planck and Navier–Stokes continuum modeling further clarifies the role of ion concentration polarization. The models indicate that applying voltage across neighboring, oppositely charged pores creates an ion-enriched zone at the entrance of one barrel that feeds the depletion zone at the entrance of the second barrel, thereby mitigating ion concentration polarization and increasing the combined conductance. These experiments and models advance understanding of electrically and chemically addressable, interacting nanopores for future ionic circuits.","PeriodicalId":62,"journal":{"name":"The Journal of Physical Chemistry Letters","volume":"23 1","pages":""},"PeriodicalIF":6.475,"publicationDate":"2026-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149374901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extracellular Polymeric Substances Govern Horizontal Gene Transfer of Antibiotic Resistance Genes: Mechanisms, Pathway Specificity, and Research Gaps","authors":"Long Cheng,Jun-Hua Ai,Kai Cheng,Ying Liu,Cheng-Yi Luo,Yi-Bo Zhang,Dong-Feng Liu","doi":"10.1021/acs.est.6c08470","DOIUrl":"https://doi.org/10.1021/acs.est.6c08470","url":null,"abstract":"The dissemination of antibiotic resistance genes (ARGs) in environmental systems is recognized as being shaped by local matrix conditions, yet the pathway-specific role of extracellular polymeric substances (EPS), the dominant matrix of biofilms, sludge flocs, and granules, remains poorly resolved. In this Review, we develop a mechanism- and pathway-resolved perspective for evaluating how EPS govern horizontal gene transfer (HGT) of ARGs. Current evidence indicates that conjugation is the most directly supported pathway, with EPS facilitating or restricting transfer through effects on donor–recipient contact, matrix organization, and transfer-related physiology. For transformation, EPS-associated extracellular ARGs constitute reservoirs, but EPS–DNA binding can both preserve genetic material and limit its immediate bioavailability. By contrast, EPS involvement in phage-mediated transduction and vesicle-mediated transfer remains mechanistically plausible but insufficiently validated. We identify five interconnected mechanisms: physical retention and spatial organization, DNA adsorption and bioavailability, regulation of intercellular contact, modulation of cell physiology and transfer competence, and community-scale mobilome coupling. By clarifying evidence boundaries across pathways, this Review moves EPS–HGT research from correlation-based interpretation toward mechanism-informed assessment of ARG mobility. We conclude by outlining research needs, including standardized EPS definition and extraction, component-resolved characterization, pathway-resolved causal assays, and validation in realistic environmental aggregates.","PeriodicalId":36,"journal":{"name":"环境科学与技术","volume":"7 1","pages":""},"PeriodicalIF":9.028,"publicationDate":"2026-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149374754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chemically Stratified Urban Boundary Layer: Seasonally Reversing Vertical Changes in the Underlying Chemistry of Atmospheric Oxidation Capacity","authors":"Xin Song,Xiao-Bing Li,Bin Yuan,Jing Chen,Zhenguo Liu,Yongxin Song,Yibo Huangfu,Linqiang Liu,Huiyu Jiang,Jian Chen,Peng Cheng,Haichao Wang,Xiaorui Chen,Yaqin Gao,Hongli Wang,Shengrong Lou,Guiqian Tang,Min Shao","doi":"10.1021/acs.est.6c10710","DOIUrl":"https://doi.org/10.1021/acs.est.6c10710","url":null,"abstract":"The vertical structure of atmospheric oxidation capacity (AOC) and its underlying radical chemistry within the urban boundary layer remains poorly characterized, yet it governs secondary pollutant formation. Here, we combined tower-based vertical observations with process-resolved model simulations in Beijing across winter and summer. We find that AOC generally declined with height in both seasons, but radical concentrations exhibit opposite vertical gradients. Notably, enhanced biogenic volatile organic compounds (VOCs) emissions in summer suppress near-surface OH levels, creating a mid-altitude maximum. However, sharp vertical NO gradients drove an increase in ROx with height in winter. The underlying chemistry of vertical AOC variation shifts with the seasons. In winter, the photolysis of HONO dominates ROx production, and NOx-driven ROx loss prevails. In summer, the photolysis of oxygenated VOCs takes over, with radical self-reactions as the primary ROx sink. These findings demonstrate that surface observations alone may provide an incomplete representation of the whole boundary-layer chemistry.","PeriodicalId":36,"journal":{"name":"环境科学与技术","volume":"14 1","pages":""},"PeriodicalIF":9.028,"publicationDate":"2026-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149374760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emerging CRISPR Technologies for Environmental Protection: From Genetic Engineering and Biosensing to Environmental Deployment","authors":"Leyao Yang,Sage Sanders,David Wamwende,Han Gyu Lee,Yoon Jung Do,Kyoung-Jin Yoon,Ke Du,Huiyuan Guo","doi":"10.1021/acs.est.6c06458","DOIUrl":"https://doi.org/10.1021/acs.est.6c06458","url":null,"abstract":"Since its discovery, Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) has revolutionized biomedical science and engineering with its ability to recognize and edit gene sequences with high specificity and precision. Despite the growing interest in using these capabilities to address environmental and sustainability challenges, the broader potential of CRISPR in environmental systems remains unexplored relative to its biomedical applications. Here, we provide a critical perspective on the emerging use of CRISPR for pollution management, ecological conservation, and environmental monitoring. Rather than viewing CRISPR solely as a gene-editing or biosensing technology, we consider both capabilities together to examine how advances in CRISPR engineering can translate into practical environmental solutions. We highlight the fundamental principles behind CRISPR-based editing and sensing and evaluate the challenges that constrain their transition from proof-of-concept experiments to field deployment, including off-target effects, delivery methods, ecological risks, and low sensitivity. Addressing these hurdles requires a multifaceted approach that integrates emerging technologies such as reversible CRISPR technology, amplification and cascade reactions, and machine learning, with strict regulatory oversight and rigorous risk assessments. This perspective identifies critical strengths, weaknesses, and research priorities for advancing CRISPR from laboratory technology toward robust tools for environmental applications.","PeriodicalId":36,"journal":{"name":"环境科学与技术","volume":"9 1","pages":""},"PeriodicalIF":9.028,"publicationDate":"2026-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149374761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radical Anion-Driven, Photocatalyst-Free α-Aminoalkylation of Quinoxalin-2(1H)-ones","authors":"Nawaphon Saartaiam,Naiyana Saesian,Tomohiro Isono,Rungroj Saruengkhanphasit,Somsak Ruchirawat,Worawat Niwetmarin","doi":"10.1021/acs.joc.6c02100","DOIUrl":"https://doi.org/10.1021/acs.joc.6c02100","url":null,"abstract":"Radical C–H functionalization at the α-position of amines has intrigued organic chemists for decades. To overcome the requirement for harsh conditions, our strategy involves the 1,5-HAT process to efficiently generate the α-aminoalkyl radical. The reaction is promoted by the formate anion, a single electron reductant, and shows a wide range of compatibility with various quinoxalin-2(1H)-one derivatives and amines. Mechanistic investigations and DFT calculations reveal that the intermediate from radical addition shows a strong reducing ability to propagate the C–H functionalization without the need for a photocatalyst.","PeriodicalId":57,"journal":{"name":"Journal of Organic Chemistry","volume":"51 1","pages":""},"PeriodicalIF":4.354,"publicationDate":"2026-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149374806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experimental and Theoretical Charge Density Study of Isonicotinamide Polymorphs","authors":"Shagun Gogna,Debra J. Iskandar,Jonathan J. Du,Paul W. Groundwater,Jan-Willem C. Alffenaar,Jonathan C. Arnold,David E. Hibbs","doi":"10.1021/acs.jpcc.6c05509","DOIUrl":"https://doi.org/10.1021/acs.jpcc.6c05509","url":null,"abstract":"Isonicotinamide is widely studied for its strong and directional hydrogen bonds, which play a critical role in crystal engineering and polymorphism. To address the absence of a quantitative charge density comparison for the two most studied isonicotinamide polymorphs (denoted 1a and 1b), this study maps the electron density distribution and topological properties of 1a and 1b, which differ in intermolecular connectivity, linking their respective H-bonding networks, intermolecular interaction strengths and lattice energetics within a single experimental and theoretical framework. High-resolution X-ray diffraction data were analyzed using the Hansen–Coppens multipole model. Topological parameters at bond critical points were evaluated to quantify hydrogen bonding, weak interactions, and electron density redistribution across the molecule. Both polymorphs exhibit well-defined hydrogen bonding networks dominated by N–H···N interactions, with bond strengths ranging from 6.48 to 35.5 kJ mol–1. Topological analysis revealed high electron densities and negative Laplacian values for covalent bonds, whereas the hydrogen-bond critical points exhibited positive Laplacian values consistent with closed-shell interactions. Notably, 1a shows stronger lattice stabilization (−114 kJ mol–1) compared to 1b (−82 kJ mol–1), indicating more efficient packing. By mapping the electron density topology and energy framework partitioning that distinguish the more stable P21/c form 1a from its less efficiently packed polymorph 1b (also P21/c), at the atomic level, this study provides a quantitative reference framework that can be used to predict and rationalize stability and solubility differences among the growing family of isonicotinamide-based pharmaceutical cocrystals.","PeriodicalId":61,"journal":{"name":"The Journal of Physical Chemistry C","volume":"75 1","pages":""},"PeriodicalIF":4.126,"publicationDate":"2026-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149374871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}