化学•材料最新文献

{"title":"Bismuth based nanomaterials: Design, synthesis and applications in tumor synergistic therapy.","authors":"Qiupeng Zhang, Jie Tu, Yuqin Jiang, Huihui Wang, Weixian Xue, Chunyao Dong, Ruizhuo Ouyang, Yuqing Miao","doi":"10.1016/j.colsurfb.2025.114992","DOIUrl":"10.1016/j.colsurfb.2025.114992","url":null,"abstract":"<p><p>With the rapid development of nanomedicine, nanomaterials (NMs) have been used in clinical medicine to improve treatment efficiency. Bismuth-based nanomaterials(BNMs) are promising candidates for cancer diagnosis and therapy because of their good biocompatibility, low cost, high X-ray attenuation and near infrared absorption coefficient. The traditional therapy mode is relatively single, and the treatment effect is not significantly improved. Therefore, the combination of traditional treatment and emerging treatment not only has high lethality to tumor cell, but also makes up for their shortcomings. This review summarizes the latest research on BNMs in tumor therapy in recent years, including: the design and preparation of BNMs, the synergy of multiple treatment technologies, and the biosafety of nanomaterials. In the end, the inspiration and reference for the study of Bi-based multifunctional nano-platforms were provided for clinical use.</p>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"256 Pt 1","pages":"114992"},"PeriodicalIF":5.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144803079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quaternized chitosan-coated PLGA nanoparticles co-deliver resveratrol and all-trans retinoic acid to enhance humoral immunity, cellular immunity and gastrointestinal mucosal immunity.","authors":"Dan Yang, Nannan Wang, Lijuan Cao, Huimao Liu, Hanyan Cheng, Haitao Ma, Lixia Li, Yuanfeng Zou, Xinghong Zhao, Xun Zhou, Xu Song, Dongmei Zhang, Mingyue Li, Renyong Jia, Zhongqiong Yin","doi":"10.1016/j.colsurfb.2025.114994","DOIUrl":"10.1016/j.colsurfb.2025.114994","url":null,"abstract":"<p><p>Conventional vaccine adjuvants are limited by their mechanisms of action and administration routes, often failing to simultaneously elicit robust systemic and mucosal immune responses. This limitation compromises the establishment of dual protective barriers during early pathogen invasion. Therefore, we developed an innovative poly (lactic-co-glycolic acid) (PLGA) nanoparticle-based adjuvant system (Res/RA QCS NPs) featuring quaternized chitosan (QCS) surface modification for ovalbumin (OVA) delivery, co-encapsulating dual immunomodulators - resveratrol (Res) and all-trans retinoic acid (RA). The results showed that the Res/RA QCS NPs possessed excellent antigen adsorption capacity (adsorption rate of 93.87 ± 5.27 %) and significantly enhanced the recruitment of antigen-presenting cells (APCs) at the injection site and lymph node-targeting delivery. In vitro immunological evaluation further confirmed that OVA-Res/RA QCS NPs possessed excellent immune-enhancing properties, including: efficient antigen internalization, Dendritic Cells (DCs) maturation activation, enhanced cytokine secretion and mucosal homing ability. In vivo immunity experiments, OVA-Res/RA QCS NPs not only induced high levels of serum antigen-specific IgG antibodies and proliferation and activation of T cells in peripheral lymphoid tissues, but also stimulated the secretion of large amounts of antigen-specific IgA in the gastrointestinal mucosa, which realized the dual activation of systemic and mucosal immunity. This study provides an important theoretical and experimental basis for the development of novel vaccine adjuvants and immunotherapy strategies based on intestinal immunomodulation.</p>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"256 Pt 1","pages":"114994"},"PeriodicalIF":5.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144797767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Orthogonal programmed tri-modal tumor treatment based on structurally simple nanomedicines.","authors":"Peidong Yang, Zhitang Wang, Xianquan Liao, Qingqin Peng, Yuxin Liu, Debo Chen","doi":"10.1016/j.colsurfb.2025.115001","DOIUrl":"10.1016/j.colsurfb.2025.115001","url":null,"abstract":"<p><p>Orthogonal multimodal therapy is a highly effective strategy for tumor ablation, yet they require nanomedicines with complex structures that are difficult to use practically. Here, a structurally simple nanomedicine is constructed by independently modified boron-doped carbon quantum dots (B-CDs) with nicorandil by physical absorption and epigallocatechin gallate (EGCG) through borate ester bonding, respectively. In the redox-imbalance tumor microenvironment, nicorandil (NIC) produce NO for gas therapy in response to intratumoral GSH and HSP90 is inhibited due to H₂O₂-triggered EGCG release, while B-CDs generate local hyperthermia under near-infrared light. Therefore, this nanomedicine can exercise specific therapeutic modes in response to different tumor microenvironmental characteristics or external stimuli under fluorescence supervision.</p>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"256 Pt 1","pages":"115001"},"PeriodicalIF":5.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144815444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In vitroresponse of mouse astrocyte cells on electrospun PVA/gelatin nanofibers: The role of gelatin content and fiber alignment.","authors":"Nergis Zeynep Renkler, Guido Mogni, Stefania Scialla, Iriczalli Cruz-Maya, Grazia Paola Nicchia, Vincenzo Guarino","doi":"10.1016/j.colsurfb.2025.115023","DOIUrl":"10.1016/j.colsurfb.2025.115023","url":null,"abstract":"<p><p>Astrocytes are key supportive cells in the central nervous system (CNS), responsible for neural repair, synapse formation, and maintaining neural health. In this work, the optimization of crosslinking treatments to fabricate polyvinyl alcohol (PVA)/gelatin electrospun nanofibers was investigated to remark the effect of chemical - i.e., gelatin - and topological - i.e., fiber orientation - cues on the in vitro activity of mouse astrocytes. Fiber morphology deeply explored via Scanning Electron Microscopy (SEM)/image analysis highlighted a significant decay of the average diameter as the gelatin content - from 0.955 ± 0.146 μm (7:3) to 0.599 ± 0.1 μm (5:5) - or in the presence of preferential fiber alignment - 0.662 ± 0.204 μm (7:3). Assessment of the cell survival revealed that astrocytes were better able to survive and proliferate on nanofibers with gelatin than on those without any addition of gelatin nanofibers. In this context, the alignment of nanofibers enhanced not only the attachment of astrocytes but also their spatial orientation playing a critical role in directing the growth of astrocytes as confirmed by immunofluorescence studies. The electrospun PVA/gelatin (PVAG) structures, especially with uniaxial fiber orientation, proved to be a potential substrate for the culture of astrocytes and construction of CNS tissues. The role of biological macromolecules, such as gelatin, allows to support in vitro astrocyte function, thus offering new avenues for neural tissue engineering and regenerative medicine.</p>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"256 Pt 1","pages":"115023"},"PeriodicalIF":5.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144815442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"TiO₂/PANI-based sensing electrode for ethanol detection in human sweat to monitor liver functioning.","authors":"Bhavya Padha, Isha Yadav, Sandeep Arya","doi":"10.1016/j.colsurfb.2025.114991","DOIUrl":"10.1016/j.colsurfb.2025.114991","url":null,"abstract":"<p><p>Wearable sensors for detecting ethanol volatile organic compounds (VOCs) in sweat offer a non-invasive approach to monitor liver health. In line with this goal, a titanium dioxide/polyaniline (TiO₂/PANI) nanocomposite-based sensor electrode was developed for real-time ethanol detection under standard conditions (300 K, 1 atm). The thin film, deposited on a conductive fabric, was characterized for phase, structure, and morphology. Electrochemical tests showed high sensitivity, with a detection limit of 23.62 ppb and quantification of 71.59 ppb. The sensor demonstrated excellent reproducibility, stability, and selectivity across various ethanol concentrations. It effectively distinguished between sweat samples from healthy and liver-affected individuals and maintained performance over 100 days under varying humidity and temperature.</p>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"256 Pt 1","pages":"114991"},"PeriodicalIF":5.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144811489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tailorable and biocompatible collagen-based peptides as distinctive surfactants with micellar self-assembly.","authors":"Smriti Mukherjee, Manaswini Gowtham, Ganeshkumar Yogeswaran, Sonam Jangra, Madivala G Basavaraj, Vinod K Aswal, Kanagasabai Balamurugan, Niraikulam Ayyadurai, Ganesh Shanmugam","doi":"10.1016/j.colsurfb.2025.115004","DOIUrl":"10.1016/j.colsurfb.2025.115004","url":null,"abstract":"<p><p>Surface-active peptides (SAPs) typically mimic conventional surfactants by featuring long non-polar (hydrophobic) peptide tails and short polar (hydrophilic) heads consisting of a single amino acid or short peptide. However, reverse-structure SAPs-with a long hydrophilic tail and short hydrophobic head-remain largely unexplored. If developed, such SAPs could form micelles with a larger hydrophilic area and a smaller hydrophobic core, leading to novel self-assembled structures. We hypothesize that combining the self-assembly potential of an aromatic moiety as a short hydrophobic head with the linear hydrophilic properties of collagen-like peptides containing Glycine-Proline-Hydroxyproline (GPO) repeats can lead to the development of these unique reverse SAPs. These SAPs are expected to form unique self-assembled structures with a larger hydrophilic area and a smaller hydrophobic core, contributing to advancements in colloidal and interface science. To validate this hypothesis, π-system-functionalized collagen-like peptides were designed using (GPO)_n (n = 1-5) as extended hydrophilic tails and a fluorenyl aromatic π-system as the hydrophobic head. Biophysical studies evaluated their self-assembly, critical micellar concentration, and surface activity, focusing on stabilization mechanisms driven by aromatic π-π interactions and hydrogen bonding. The SAPs exhibited surface activity and formed micelles at sub-millimolar concentrations. Longer hydrophilic tails resulted in lower CMC values, indicating enhanced self-assembly. The micelles were stabilized by π-π stacking and hydrogen bonding, creating unique self-assembled structures with a larger hydrophilic region and a smaller hydrophobic core. These findings provide new insights into colloids and interface science and open avenues for applying reverse-structure SAPs in drug delivery.</p>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"256 Pt 1","pages":"115004"},"PeriodicalIF":5.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144815445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mannose receptor targeted PLGA nanoparticles ofEucommia ulmoidespolysaccharide through the MAPK and NF-κB pathway to enhance the immune activity of BMDCs.","authors":"Xin Hu, Jia Meng, Yi Liao, Yanwen Yang, Yao Wang, Zhenhui Song, Ziwei Liu, Haibo Feng","doi":"10.1016/j.colsurfb.2025.115002","DOIUrl":"10.1016/j.colsurfb.2025.115002","url":null,"abstract":"<p><p>Mannosylated poly(lactic-co-glycolic acid) (PLGA) nanoparticles encapsulating Eucommia ulmoides polysaccharides (EOPP) were developed as a targeted immunomodulatory delivery system. In vitro evaluations confirmed that EOPP exhibited low cytotoxicity toward spleen lymphocytes while significantly increasing their proliferation and cytokine secretion (IL-6 and IFN-γ). When co-delivered with ovalbumin (MN-EOPP/OVA), the system further enhanced the secretion of TNF-α, IL-12, IL-6, and IFN-γ by immune cells and induced cytoskeletal remodeling and maturation in bone marrow-derived dendritic cells (BMDCs). Transcriptomic profiling revealed significant upregulation of immune-related genes, with KEGG and PPI analyses identifying activation of key signaling pathways, including MAPK (ERK, p38, JNK) and NF-κB. These pathways drive the expression of genes involved in antigen processing and dendritic cell function. Overall, MN-EOPP/OVA effectively enhanced both humoral and cellular immune responses by synergistic delivery of antigen and immunopotentiator, supporting its potential as a next-generation vaccine adjuvant strategy.</p>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"256 Pt 1","pages":"115002"},"PeriodicalIF":5.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144815443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Wearable electrochemical immunosensor based on ultra-thin flexible stainless steel sheets for detection of methyl jasmonate in tomato leaves.","authors":"Yali Zhang, Xinliu Geng, Linbing Ma, Mengting Li, Xinyue Zhao, Ling Sun, Rong Tan, Lijun Sun","doi":"10.1016/j.bios.2025.117853","DOIUrl":"10.1016/j.bios.2025.117853","url":null,"abstract":"<p><p>Methyl jasmonate (MeJA), a key plant hormone, plays essential roles in plant growth, development, biotic stress responses, and wound-induced defense. Monitoring dynamic changes in MeJA in situ is vital for botanical research. Herein, coupling with paper-based analytical devices, the ultra-thin flexible stainless steel sheets with the excellent flexibility and conductivity were used to develop wearable electrochemical immunosensor for in situ and continuous detection of MeJA in plants. The ultra-thin flexible stainless steel sheets were modified with conducting carbon cement, ferrocene - graphene oxide - multi-walled carbon nanotubes composites, and MeJA antibodies to construct the wearable electrochemical immunosensor, which can detect the MeJA in the range of 10 pM-100 μM, and with a limit of detection of 5.4 pM. Using this wearable electrochemical immunosensor, the MeJA content in tomato leaves under wound stimulation was detected in situ and continuously. The results showed that MeJA levels in tomato leaves increased significantly with mechanical damage. A significant difference was observed between the untreated control group (0 cm) and the mechanically damaged group (2.0 cm), confirming the sensor's capability to monitor dynamic changes in MeJA in response to stress in real-time. In all, this study not only suggested that the ultra-thin flexible stainless steel sheets with the excellent flexibility and conductivity can be used to fabricated the wearable electrochemical sensors, but also provided a novel method for continuous in situ MeJA detection, which contributed to the understanding of MeJA regulatory mechanisms in plants and advancing precision agriculture technologies.</p>","PeriodicalId":259,"journal":{"name":"Biosensors and Bioelectronics","volume":"288 ","pages":"117853"},"PeriodicalIF":10.5,"publicationDate":"2025-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144797766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel thermo-activated one-pot RPA-CRISPR-Cas12b assay for Mycoplasma pneumoniae POCT.","authors":"Jiayu Feng, Ze Wu, Wenhui Zhu, Fei Jin, Minghai Zhao, Wenjie Zhong, Chen Dai, Yongjian He, Lizhi Yan, Shengquan Wu, Yuhang Wang, Yongyu Rui, Lei Zheng, Qiangqiang Fu","doi":"10.1016/j.bios.2025.117839","DOIUrl":"10.1016/j.bios.2025.117839","url":null,"abstract":"<p><p>Mycoplasma pneumoniae (M. pneumoniae), a major human respiratory pathogen, necessitates the development of rapid point-of-care testing (POCT) platforms for clinical management. However, current two-step workflows suffer from operational complexity and aerosol contamination risks. This limitation stems from CRISPR-Cas12 mediated template degradation in single-reaction systems, which compromises amplification efficiency and detection sensitivity. Here, we combined RPA and CRISPR Cas12b by leveraging the difference in their optimal temperatures to construct a novel TRACER (Thermo-activated RPA Amplification for CRISPR-Cas12b Efficient Recognition) technology. Through precise temperature modulation, TRACER sequentially executes isothermal amplification and CRISPR-mediated detection while preventing premature template cleavage, thereby maintaining optimal reaction efficiency. The platform demonstrates exceptional analytical sensitivity with a detection limit of 1 copy/μL, representing a 100-fold improvement over conventional one-pot RPA-CRISPR-Cas12a systems. Clinical validation using 195 specimens revealed diagnostic performance metrics of 99.2 % sensitivity (119/120), 100.0 % specificity (75/75), and 99.5 % accuracy (194/195). This innovative combination of single-tube reaction, field-deployable instrumentation, and cost-effectiveness establishes TRACER as an ideal POCT solution for M. pneumoniae detection in diverse clinical settings.</p>","PeriodicalId":259,"journal":{"name":"Biosensors and Bioelectronics","volume":"288 ","pages":"117839"},"PeriodicalIF":10.5,"publicationDate":"2025-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144803041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An artificial intelligence-assisted, kilometer-scale wireless and wearable biochemical sensing platform for monitoring of key biomarkers in urine.","authors":"Yan Dong, Wenzheng An, Yongbin Zhang, Zehao Kang, Botao Gao, Juntai Lv, Yixuan Jiang, Chang Niu, Yuling Mao, Dongzhi Zhang","doi":"10.1016/j.bios.2025.117844","DOIUrl":"10.1016/j.bios.2025.117844","url":null,"abstract":"<p><p>Wearable biochemical sensors enabling non-invasive monitoring of biomarkers in bodily fluids play a pivotal role in advancing personalized healthcare. The state-of-the-art wireless and wearable biochemical sensors still suffer from large form factors, poor detection accuracy due to sample-to-sample variation, short and weak wireless communication, and difficulty to integrate with data processing algorithm on a system level. To solve these problems, this work develops an all-range wireless and wearable biochemical sensing platform which can be integrated in a diaper for monitoring four urine biomarkers (dimethylamine, creatinine, glucose, and H⁺) with two switchable wireless modes. To simplify the circuit design and reducing the form factor of the wearable sensing platform, this work develops flexible and passive potentiometric sensing interfaces for dimethylamine and creatinine detection by developing high-performance ion-selective electrode (ISE) with customized molecularly imprinted polymers (MIPs) as ionophores. The narrowband Internet of Things (NB-IoT) far-field wireless mode enables remote, and concurrent monitoring of urine biomarkers with a working range up to tens of kilometers, while the LC resonance near-field wireless mode is capable of battery-free and intermittent detection of urine biomarkers. The wearable sensor can be easily switched between the NB-IoT far-field wireless mode and the near-field wireless mode to fit different application scenarios. The wireless sensing platform enables system level integration of the wearable biochemical sensor with a multilayer perceptron data calibration system for data auto-calibration, which reduces the errors caused by varying pH and thus improves the detection accuracy, enabling deeper AI-wearable biochemical sensor fusion for next-generation healthcare applications.</p>","PeriodicalId":259,"journal":{"name":"Biosensors and Bioelectronics","volume":"288 ","pages":"117844"},"PeriodicalIF":10.5,"publicationDate":"2025-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144803042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}