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Hydrothermal liquefaction: Transforming waste into renewable fuels and high-value bio-chemicals 水热液化:将废物转化为可再生燃料和高价值的生物化学品
IF 16.3 1区 工程技术
Renewable and Sustainable Energy Reviews Pub Date : 2025-06-23 DOI: 10.1016/j.rser.2025.115974
Tumpa R. Sarker , Bristy Sarker , Biswajit Saha , Mst. Lucky Khatun , Ajay K. Dalai
{"title":"Hydrothermal liquefaction: Transforming waste into renewable fuels and high-value bio-chemicals","authors":"Tumpa R. Sarker ,&nbsp;Bristy Sarker ,&nbsp;Biswajit Saha ,&nbsp;Mst. Lucky Khatun ,&nbsp;Ajay K. Dalai","doi":"10.1016/j.rser.2025.115974","DOIUrl":"10.1016/j.rser.2025.115974","url":null,"abstract":"<div><div>Lignocellulose, being abundant, eco-friendly, and sustainable, shows great potential as a replacement for fossil fuels. Hydrothermal liquefaction is a highly effective method for converting biomass into liquid fuels and valuable chemicals. This review uniquely compiles and compares the reaction pathways of individual biomass components (cellulose, hemicellulose, lignin, lipids, and proteins), offering mechanistic insights not often found collectively in the literature. Additionally, it presents a comprehensive evaluation of the influence of process parameters such as the types of feedstocks, temperature, heating rate, retention time, pressure, solid-to-liquid ratio, and catalysts on HTL product distribution. Furthermore, the upgradation techniques for upgrading biocrude to various valuable biofuels and platform chemicals were extensively explored. The review also integrates techno-economic and life cycle assessment findings, providing a holistic view of HTL's industrial feasibility. These consolidated insights help identify key challenges and future directions for enhancing HTL technology, making this review a valuable reference for both researchers and practitioners.</div></div>","PeriodicalId":418,"journal":{"name":"Renewable and Sustainable Energy Reviews","volume":"222 ","pages":"Article 115974"},"PeriodicalIF":16.3,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144338970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A critical review on ammonia as a fuel for internal combustion engines: Is it a viable option? 关于氨作为内燃机燃料的重要评论:它是一个可行的选择吗?
IF 16.3 1区 工程技术
Renewable and Sustainable Energy Reviews Pub Date : 2025-06-23 DOI: 10.1016/j.rser.2025.115964
Asiye doosti , Marziyeh Hoseinpour , Mohammad G. Rasul , Rahim Karami , Nur M.S. Hassan , Behdad Moghtaderi
{"title":"A critical review on ammonia as a fuel for internal combustion engines: Is it a viable option?","authors":"Asiye doosti ,&nbsp;Marziyeh Hoseinpour ,&nbsp;Mohammad G. Rasul ,&nbsp;Rahim Karami ,&nbsp;Nur M.S. Hassan ,&nbsp;Behdad Moghtaderi","doi":"10.1016/j.rser.2025.115964","DOIUrl":"10.1016/j.rser.2025.115964","url":null,"abstract":"<div><div>Ammonia is considered an attractive alternative fuel for power generation in the context of global decarbonisation efforts. This study examines the advancements in ammonia combustion technology for spark ignition (SI) and compression ignition (CI) engines. An extensive analysis of the characteristics of ammonia (NH<sub>3</sub>) combustion, a fuel free of carbon, is provided in this paper. Since ammonia burns similarly to fossil fuels and emits less CO<sub>2</sub>, CO, NO<sub>x</sub>, soot, and hydrocarbon (HC) pollutants, NH<sub>3</sub> is a desirable substitute fuel that can be stored and transported using existing commercial infrastructure. It also comes with productivity from renewable sources. However, unlike traditional hydrocarbon fuels, NH<sub>3</sub> exhibits unique combustion characteristics, highlighting the challenges of using it as a fuel for internal combustion (IC) engines. This paper critically reviews the challenges of NH<sub>3</sub> blended with diesel, biodiesel, dimethyl ether, and some other alternative fuels in IC engines. The literature reports mixed findings on this topic. Many studies have not demonstrated NH<sub>3</sub> as a substitute fuel for IC engines yet. In addition, ammonia's toxicity and unusual/complex combustion characteristics hinder its use as a fuel substitute in IC engines. Further research is required to overcome challenges associated with using NH<sub>3</sub> as a fuel for IC engines. This study identifies and discusses these challenges.</div></div>","PeriodicalId":418,"journal":{"name":"Renewable and Sustainable Energy Reviews","volume":"222 ","pages":"Article 115964"},"PeriodicalIF":16.3,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144338971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Revolutionizing microelectronics cooling: Thermal management with nano-enhanced PCMs, hybrid cooling, conductive foams, and porous structures 革命性的微电子冷却:热管理与纳米增强pcm,混合冷却,导电泡沫和多孔结构
IF 16.3 1区 工程技术
Renewable and Sustainable Energy Reviews Pub Date : 2025-06-23 DOI: 10.1016/j.rser.2025.115954
Poongavanam GaneshKumar , G. Praveen Kumar , Vinothkumar Sivalingam , S. Divya , Tae Hwan Oh
{"title":"Revolutionizing microelectronics cooling: Thermal management with nano-enhanced PCMs, hybrid cooling, conductive foams, and porous structures","authors":"Poongavanam GaneshKumar ,&nbsp;G. Praveen Kumar ,&nbsp;Vinothkumar Sivalingam ,&nbsp;S. Divya ,&nbsp;Tae Hwan Oh","doi":"10.1016/j.rser.2025.115954","DOIUrl":"10.1016/j.rser.2025.115954","url":null,"abstract":"<div><div>Electronic cooling has become crucial for applications in electric vehicles, aerospace, power plants, and high-performance computing, where managing heat generation is vital for operational efficiency. Direct and indirect cooling approaches, along with advanced materials like carbon, metal, and PVDF foam, nanofluids, and phase change materials (PCMs), offer promising solutions for implementing thermal challenges. This review recommends a comprehensive assessment of cooling technologies, highlighting their role in improving energy efficiency and supporting clean energy transitions while tackling challenges like stability, scalability, and material properties. The role of nanofluids and PCMs in thermal regulation is emphasized, as they efficiently manage transient heat loads by storing and releasing thermal energy, maintaining optimum operating temperatures, and mitigating thermal excursions. Advanced configurations, namely heat pipes and micro-channel heat exchangers demonstrate exceptional thermal management performance in high-heat flux scenarios. Heat sinks with their interconnected pore structures, enhance heat transfer through combined conduction and convective mechanisms. The integration of advanced materials substantially enhances thermal conductivity, heat dissipation, improved thermal stability, and operational efficiency. The integration of Artificial Intelligence and Machine Learning in thermal systems augments predictive modeling and adaptive control, leading to enhanced reliability and prolonged operational durability of system components and overall functionality.</div></div>","PeriodicalId":418,"journal":{"name":"Renewable and Sustainable Energy Reviews","volume":"222 ","pages":"Article 115954"},"PeriodicalIF":16.3,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144338969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dexamethasone prodrug cyclodextrin aggregates effectively alleviate experimental autoimmune uveitis 地塞米松前药环糊精聚集体有效缓解实验性自身免疫性葡萄膜炎
IF 5.4 2区 医学
Colloids and Surfaces B: Biointerfaces Pub Date : 2025-06-21 DOI: 10.1016/j.colsurfb.2025.114889
Xue Wang , Lu Liu , Di Wu , Yuxin Hu , Hongzhuo Liu , Yizhou Sun , Guangqi Yan
{"title":"Dexamethasone prodrug cyclodextrin aggregates effectively alleviate experimental autoimmune uveitis","authors":"Xue Wang ,&nbsp;Lu Liu ,&nbsp;Di Wu ,&nbsp;Yuxin Hu ,&nbsp;Hongzhuo Liu ,&nbsp;Yizhou Sun ,&nbsp;Guangqi Yan","doi":"10.1016/j.colsurfb.2025.114889","DOIUrl":"10.1016/j.colsurfb.2025.114889","url":null,"abstract":"<div><div>Noninfectious uveitis (NIU) remains a significant cause of vision impairment, typically managed with glucocorticoids. However, current glucocorticoid implants present considerable side effects, including elevated intraocular pressure and cataracts. To overcome these limitations, we synthesized a novel prodrug, dexamethasone gallate (DG), which possesses the powerful anti-inflammatory ability of dexamethasone (DEX) and exhibits strong antioxidant activity of gallic acid (GA) that helps protect ocular tissues against oxidative stress. DG was formulated into cyclodextrin microparticle suspension eye drops, designed to progressively disintegrate and penetrate ocular tissues effectively. In experimental autoimmune uveitis (EAU) models, DG suspension eye drops demonstrated comparable therapeutic efficacy to conventional DEX eye drops at reduced dosages, significantly reducing anterior and posterior ocular inflammation. Notably, DG formulations substantially minimized intraocular pressure elevation and glucocorticoid-related adverse effects. These findings support the potential of DG suspension eye drops as a safer, efficient, and patient-friendly therapeutic alternative for treating NIU.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"255 ","pages":"Article 114889"},"PeriodicalIF":5.4,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144338305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Proteomics-Based Trapping to Study Substrates of Histone Deacetylase 6 Catalytic Domain 1. 基于蛋白质组学的组蛋白去乙酰化酶6催化结构域1底物研究
IF 2.9 3区 生物学
Biochemistry Biochemistry Pub Date : 2025-06-21 DOI: 10.1021/acs.biochem.5c00072
Udana V Ariyaratne, Valentine O Nwanelo, Rachael T Tiamiyu, Ishadi K M Kodikara, Mary Kay H Pflum
{"title":"Proteomics-Based Trapping to Study Substrates of Histone Deacetylase 6 Catalytic Domain 1.","authors":"Udana V Ariyaratne, Valentine O Nwanelo, Rachael T Tiamiyu, Ishadi K M Kodikara, Mary Kay H Pflum","doi":"10.1021/acs.biochem.5c00072","DOIUrl":"https://doi.org/10.1021/acs.biochem.5c00072","url":null,"abstract":"<p><p>Histone deacetylase 6 (HDAC6) is linked with various cellular functions, such as gene expression and protein degradation, as well as many diseases, including breast cancers and Alzheimer's disease. HDAC6 removes the acetyl group of acetyllysine from histones to regulate gene expression in the nucleus. However, with predominant localization in the cytoplasm, various cytoplasmic substrates of HDAC6 have also been identified. HDAC6 is unique among the other 11 metal-dependent HDAC family members due to the presence of two independent and active deacetylase domains. Recently, an inactive mutant of HDAC6 has been used as a trap to discover substrates of the second catalytic domain (CD2). Here, substrates of the first catalytic domain (CD1) of HDAC6 were explored using trapping mutants and proteomics analysis, with 21 putative substrates identified. Among them, the E3 ubiquitin ligase HUWE1 was validated as a novel HDAC6 substrate. Specifically, E3 ligase HUWE1 was deacetylated by HDAC6 CD1 to elevate degradation activity. HDAC6 CD1 also regulated the protein levels of E3 ligase UBR5. These studies document the interplay between protein deacetylation and degradation by HDAC6 CD1, which is consistent with a model where HDAC6 CD1-mediated deacetylation influences protein degradation via E3 ligases.</p>","PeriodicalId":28,"journal":{"name":"Biochemistry Biochemistry","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144339688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
TfR1-Binding Peptide Conjugation Facilitates Robust and Specific siRNA Delivery to the Central Nervous System. tfr1结合肽偶联促进强大和特异性siRNA传递到中枢神经系统。
IF 4 2区 化学
Bioconjugate Chemistry Pub Date : 2025-06-21 DOI: 10.1021/acs.bioconjchem.5c00225
Tiancheng Fu, Fushun Fan, Yingying Lin, Zhenxian Mo, Minhua Zhou, Xiaolan Ye, Xiong Cai, Zaijun Zhang, Changgeng Qian, Xinjian Liu
{"title":"TfR1-Binding Peptide Conjugation Facilitates Robust and Specific siRNA Delivery to the Central Nervous System.","authors":"Tiancheng Fu, Fushun Fan, Yingying Lin, Zhenxian Mo, Minhua Zhou, Xiaolan Ye, Xiong Cai, Zaijun Zhang, Changgeng Qian, Xinjian Liu","doi":"10.1021/acs.bioconjchem.5c00225","DOIUrl":"https://doi.org/10.1021/acs.bioconjchem.5c00225","url":null,"abstract":"<p><p>Transferrin receptor 1 (TfR1) is a ubiquitously expressed receptor characterized by rapid internalization kinetics and efficient receptor recycling, making it an attractive target for drug delivery. Herein, we investigated the potential of TfR1-binding peptide-siRNA conjugates for central nervous system (CNS)-specific gene silencing. A panel of TfR1-binding peptides and conjugation linkers were synthesized to enable siRNA attachment and evaluate their gene-silencing effects. Conjugation with the hTfR No. 894 peptide achieved effective siRNA delivery both <i>in vitro</i> and <i>in vivo</i>. Compared to ribose 2'-<i>O</i>-hexadecyl (C16)-siRNA conjugates, the hTfR No. 894-siRNA conjugation (<b>POC2</b>) elicited favorable pharmacokinetic characteristics and robust and durable silencing of the target gene across CNS regions following local administration, with minimal impact on peripheral tissues. These findings support TfR1-binding peptide conjugation as a promising strategy for CNS-targeted siRNA delivery.</p>","PeriodicalId":29,"journal":{"name":"Bioconjugate Chemistry","volume":" ","pages":""},"PeriodicalIF":4.0,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144339690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Front Cover: All-Carbon Quaternary Center Containing Tetrahydro-5H-benzo[c]fluorenes via Highly Stereoselective Transannular Carbocation Cyclization (Chem. Asian J. 11/2025) 封面:通过高立体选择性跨环碳正离子环化,含四氢- 5h -苯并[c]芴的全碳季中心亚洲J. 11/2025)
IF 3.5 3区 化学
Chemistry - An Asian Journal Pub Date : 2025-06-21 DOI: 10.1002/asia.202581101
Kasam Poonswat, Sineenart Attanonchai, Paratchata Batsomboon, Chatphorn Theppitak, Kittipong Chainok, Somsak Ruchirawat, Poonsakdi Ploypradith
{"title":"Front Cover: All-Carbon Quaternary Center Containing Tetrahydro-5H-benzo[c]fluorenes via Highly Stereoselective Transannular Carbocation Cyclization (Chem. Asian J. 11/2025)","authors":"Kasam Poonswat,&nbsp;Sineenart Attanonchai,&nbsp;Paratchata Batsomboon,&nbsp;Chatphorn Theppitak,&nbsp;Kittipong Chainok,&nbsp;Somsak Ruchirawat,&nbsp;Poonsakdi Ploypradith","doi":"10.1002/asia.202581101","DOIUrl":"https://doi.org/10.1002/asia.202581101","url":null,"abstract":"<p><b>Pulchritudinous Butterfly and Blossoming Flowers</b>: As illustrated in the artwork, the key butterfly-like [6/5] bicyclic carbocation intermediate was accessible from the achiral benzannulated cyclononene tertiary alcohol via acid-catalyzed transannular carbocation cyclization. Subsequent nucleophilic addition occurred with high stereoselectivity to afford the all-carbon C11b quaternary center-containing tetrahydro-5H-benzo[c]fluorene. More details can be found in article number e202500300 by Poonsakdi Ploypradith and co-workers.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":145,"journal":{"name":"Chemistry - An Asian Journal","volume":"20 11","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/asia.202581101","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144336109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Steric Control of Copper(II) Coordination by Carnosine: Role of the β-Alanyl Methylene Spacer 肌肽对铜(II)配位的空间控制:β-丙烯基亚甲基间隔物的作用
IF 6.475 2区 化学
The Journal of Physical Chemistry Letters Pub Date : 2025-06-21 DOI: 10.1021/acs.jpclett.5c01255
Xueyu Feng, Chunyang Wang, Yangfan He, Kaijun Yuan, Xin-Xing Zhang
{"title":"Steric Control of Copper(II) Coordination by Carnosine: Role of the β-Alanyl Methylene Spacer","authors":"Xueyu Feng, Chunyang Wang, Yangfan He, Kaijun Yuan, Xin-Xing Zhang","doi":"10.1021/acs.jpclett.5c01255","DOIUrl":"https://doi.org/10.1021/acs.jpclett.5c01255","url":null,"abstract":"Carnosine (β-alanyl-<span>l</span>-histidine), the shortest histidine-containing natural peptide in mammalian tissues, regulates crucial biological processes through Cu(II) chelation. Using a multitechnique approach combining potentiometric titration and UV–vis, EPR, FTIR, and 2D IR spectroscopy, we identified and characterized three distinct Cu(II)-carnosine complexes with pH-dependent speciation. Structural comparison with glycyl-<span>l</span>-histidine demonstrates that the extended methylene spacer of carnosine introduces unique steric constraints that (i) inhibits amide hydrogen substitution by Cu(II), (ii) facilitates formation of the binuclear species [Cu<sub>2</sub>LH<sub>–1</sub>]<sup>II</sup>, and (iii) promotes subsequent dimerization to [Cu<sub>2</sub>L<sub>2</sub>H<sub>–2</sub>] under acidic to neutral conditions. At alkaline pH, the protonation state of carnosine N-terminus serves as a critical regulator of Cu(II) coordination geometry, dictating metal binding affinity and determining site preference between N- and C-terminal coordination motifs.","PeriodicalId":62,"journal":{"name":"The Journal of Physical Chemistry Letters","volume":"70 1","pages":""},"PeriodicalIF":6.475,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144335190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Design and Evaluation of Stable Cysteine-Modified Monobody Scaffolds for Mirror-Image Synthesis. 稳定半胱氨酸修饰单体镜像合成支架的设计与评价。
IF 4 2区 化学
Bioconjugate Chemistry Pub Date : 2025-06-21 DOI: 10.1021/acs.bioconjchem.5c00181
Naoya Iwamoto, Saya Ohno, Kensuke Nakamura, Toshinori Naito, Sayaka Miura, Shinsuke Inuki, Hiroaki Ohno, Gosuke Hayashi, Hiroshi Murakami, Shinya Oishi
{"title":"Design and Evaluation of Stable Cysteine-Modified Monobody Scaffolds for Mirror-Image Synthesis.","authors":"Naoya Iwamoto, Saya Ohno, Kensuke Nakamura, Toshinori Naito, Sayaka Miura, Shinsuke Inuki, Hiroaki Ohno, Gosuke Hayashi, Hiroshi Murakami, Shinya Oishi","doi":"10.1021/acs.bioconjchem.5c00181","DOIUrl":"https://doi.org/10.1021/acs.bioconjchem.5c00181","url":null,"abstract":"<p><p>Mirror-image proteins (d-proteins) are promising therapeutic molecules with high biological stability and low immunogenicity. We recently developed a novel d-monobody scaffold variant with reduced immunogenicity. This variant incorporates two cysteine substitutions that enable the chemical synthesis of d-monobodies via native chemical ligation. In this study, the structure-activity relationship of monobody scaffold variants was investigated to identify more suitable positions for cysteine modifications. Several monobody variants with different cysteine substitution patterns and additional cysteine-selective modifications were designed and synthesized. Comprehensive functional analysis of the synthetic monobody derivatives led to the identification of a favorable monobody scaffold with potent target binding and high thermal stability. The optimized monobody scaffold with a cysteine cross-linker was used to develop d-monobody with additional functional groups.</p>","PeriodicalId":29,"journal":{"name":"Bioconjugate Chemistry","volume":" ","pages":""},"PeriodicalIF":4.0,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144339689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
NIR-triggered temperature-sensitive polydopamine nanosystem with rapid phase transition for on-demand release to enhance antibacterial and antibiofilm performance nir触发的温度敏感聚多巴胺纳米系统,具有快速的按需释放相变,以增强抗菌和抗生物膜性能
IF 5.4 2区 医学
Colloids and Surfaces B: Biointerfaces Pub Date : 2025-06-21 DOI: 10.1016/j.colsurfb.2025.114901
Mingyuan Wu, Mengru Liu, Guipeng Feng, Ruoling Jia, Rongxiang Chen, Yawen Li, Guoyi Yan, Zhen-Jiang Qiu
{"title":"NIR-triggered temperature-sensitive polydopamine nanosystem with rapid phase transition for on-demand release to enhance antibacterial and antibiofilm performance","authors":"Mingyuan Wu,&nbsp;Mengru Liu,&nbsp;Guipeng Feng,&nbsp;Ruoling Jia,&nbsp;Rongxiang Chen,&nbsp;Yawen Li,&nbsp;Guoyi Yan,&nbsp;Zhen-Jiang Qiu","doi":"10.1016/j.colsurfb.2025.114901","DOIUrl":"10.1016/j.colsurfb.2025.114901","url":null,"abstract":"<div><div>The antibiotic abuse and bacterial biofilm barriers pose a formidable challenge to global public health. To address this issue, we developed a near-infrared (NIR)-triggered temperature-sensitive polydopamine nanosystem (PDA@Ag@Cur@PCM) by integrating silver nanoparticles (AgNPs) and curcumin (Cur) with the phase change material 1-tetradecanol. The system achieved NIR-triggered on-demand drug release and synergistic photothermal-chemo antibacterial, significantly enhancing antibacterial and antibiofilm efficacy. Under NIR, the outstanding photothermal conversion capability of PACP induces the phase transition of 1-tetradecanol, facilitating precise release of Cur and Ag⁺. The PACP nanosystem can not only effectively suppress bacterial quorum sensing (QS) but also ensure Ag⁺ mediated antibacterial activity. Moreover, mild photothermal therapy (PTT) achieved potent antibacterial effects while maintaining excellent tissue biocompatibility, thereby minimized systemic toxicity. In vitro studies demonstrated that the nanoplatform efficiently disrupts mature biofilms, significantly reduces ATP levels and total carbohydrate content, while achieving remarkable antibacterial effects against <em>S. aureus</em> (98.3 %) and <em>E. coli</em> (97.2 %). By integrating low-temperature phototherapy with controlled Cur and Ag⁺ release, the PACP nanosystem represents a safe and highly effective antibiotic-free alternative, offering a promising solution for combating infections in the post-antibiotic era.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"255 ","pages":"Article 114901"},"PeriodicalIF":5.4,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144338304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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