基于结构简单的纳米药物的正交程序三模态肿瘤治疗。

IF 5.6 2区医学 Q1 BIOPHYSICS

Colloids and Surfaces B: Biointerfaces Pub Date : 2025-12-01 Epub Date: 2025-08-06 DOI:10.1016/j.colsurfb.2025.115001

Peidong Yang, Zhitang Wang, Xianquan Liao, Qingqin Peng, Yuxin Liu, Debo Chen

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引用次数: 0

摘要

正交多模态治疗是一种非常有效的肿瘤消融策略，但它需要结构复杂的纳米药物，难以实际应用。本研究分别通过物理吸收和硼掺杂碳量子点（B-CDs）与nicorandil和表没食子儿茶素没食子酸酯（EGCG）通过硼酸酯键合构建了结构简单的纳米药物。在氧化还原失衡的肿瘤微环境中，nicorandil （NIC）响应肿瘤内GSH产生NO用于气体治疗，h2o2触发EGCG释放抑制HSP90，而B-CDs在近红外光下产生局部热疗。因此，在荧光监测下，该纳米药物可以针对不同的肿瘤微环境特征或外界刺激行使特定的治疗模式。

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Orthogonal programmed tri-modal tumor treatment based on structurally simple nanomedicines.

Orthogonal multimodal therapy is a highly effective strategy for tumor ablation, yet they require nanomedicines with complex structures that are difficult to use practically. Here, a structurally simple nanomedicine is constructed by independently modified boron-doped carbon quantum dots (B-CDs) with nicorandil by physical absorption and epigallocatechin gallate (EGCG) through borate ester bonding, respectively. In the redox-imbalance tumor microenvironment, nicorandil (NIC) produce NO for gas therapy in response to intratumoral GSH and HSP90 is inhibited due to H₂O₂-triggered EGCG release, while B-CDs generate local hyperthermia under near-infrared light. Therefore, this nanomedicine can exercise specific therapeutic modes in response to different tumor microenvironmental characteristics or external stimuli under fluorescence supervision.

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来源期刊

Colloids and Surfaces B: Biointerfaces 生物-材料科学：生物材料

CiteScore

11.10

自引率

3.40%

发文量

730

审稿时长

42 days

期刊介绍： Colloids and Surfaces B: Biointerfaces is an international journal devoted to fundamental and applied research on colloid and interfacial phenomena in relation to systems of biological origin, having particular relevance to the medical, pharmaceutical, biotechnological, food and cosmetic fields. Submissions that: (1) deal solely with biological phenomena and do not describe the physico-chemical or colloid-chemical background and/or mechanism of the phenomena, and (2) deal solely with colloid/interfacial phenomena and do not have appropriate biological content or relevance, are outside the scope of the journal and will not be considered for publication. The journal publishes regular research papers, reviews, short communications and invited perspective articles, called BioInterface Perspectives. The BioInterface Perspective provide researchers the opportunity to review their own work, as well as provide insight into the work of others that inspired and influenced the author. Regular articles should have a maximum total length of 6,000 words. In addition, a (combined) maximum of 8 normal-sized figures and/or tables is allowed (so for instance 3 tables and 5 figures). For multiple-panel figures each set of two panels equates to one figure. Short communications should not exceed half of the above. It is required to give on the article cover page a short statistical summary of the article listing the total number of words and tables/figures.