Colloids and Surfaces B: Biointerfaces最新文献

Guanidine-modified polysaccharide conditioning layer designed for regulating bacterial attachment behaviors 用于调节细菌附着行为的胍修饰多糖调节层。

IF 5.4 2区医学

Colloids and Surfaces B: Biointerfaces Pub Date : 2024-09-06 DOI: 10.1016/j.colsurfb.2024.114215

{"title":"Guanidine-modified polysaccharide conditioning layer designed for regulating bacterial attachment behaviors","authors":"","doi":"10.1016/j.colsurfb.2024.114215","DOIUrl":"10.1016/j.colsurfb.2024.114215","url":null,"abstract":"<div><p>Biofouling has been persisting as a global problem due to the difficulties in finding efficient and environmentally friendly antifouling coatings for long-term applications. Initial attachment of bacteria on material surface and subsequent formation of biofilm are the predominate phenomena accounting for subsequent occurrence of biofouling. Among the various factors influencing the bacterial attachment, conditioning layer formed by organic macromolecules usually plays the key role in mediating bacterial attachment through altering physicochemical properties of substrate surface. In this study, a guanidine-modified polysaccharide conditioning layer with the capability of tuning the bacterial attachment is constructed and characterized. Dextran, a polysaccharide widespread in bacteria extracellular polymeric substances (EPS), is oxidized by sodium periodate, and cationic polymer polyhexamethylene guanidine hydrochloride (PHMG) is anchored to oxidized dextran (ODEX) by Schiff base reaction. AFM characterization reveals morphological changes of the polysaccharide conditioning layer from tangled chain to island conformation after the PHMG modification. The guanidine-based dextran conditioning layer promotes attachment of both <em>P. aeruginosa</em> and <em>S. aureus</em> and disrupted bacterial cytomembranes are seen for the attached bacteria due to electrostatic interaction of the electropositive guanidine group with the electronegative bacteria. The guanidine-based dextran conditioning layer shows a low survival ratio of 22 %-34 % and 1 %-4 % for <em>P. aeruginosa</em> and <em>S. aureus</em> respectively after incubation in the bacterial suspension for 72 hours. The results would give insight into further exploring the potential applications of the newly designed polysaccharides conditioning layer for combating occurrence of biofouling.</p></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":null,"pages":null},"PeriodicalIF":5.4,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142144526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Atrazine concentration detection based on NiAl-layer double hydroxides nanosheets synaptic transistor 基于镍层双氢氧化物纳米片突触晶体管的阿特拉津浓度检测。

IF 5.4 2区医学

Colloids and Surfaces B: Biointerfaces Pub Date : 2024-09-05 DOI: 10.1016/j.colsurfb.2024.114210

{"title":"Atrazine concentration detection based on NiAl-layer double hydroxides nanosheets synaptic transistor","authors":"","doi":"10.1016/j.colsurfb.2024.114210","DOIUrl":"10.1016/j.colsurfb.2024.114210","url":null,"abstract":"<div><p>A transistor inspired by biological systems, which possesses synaptic and sensing capabilities, has demonstrated significant promise in the field of neuromorphic electronics and sensory systems resembling the human brain. Despite the remarkable advancements in emulating neuromorphic operations, the development of a synaptic FET with a bionic architecture, extended lifespan, minimal energy usage, and marker monitoring capability remains challenging. In this work, a synaptic transistor based on NiAl-layer double hydroxides nanosheets is reported. The synaptic transistor exhibits a significant ratio of on/off current (1.35×10<sup>7</sup>) and possesses a high transconductance value (10.05 mS). The successful emulation included key synaptic characteristics, such as excitatory/inhibitory postsynaptic current, paired-pulse facilitation/depression, short-term plasticity spike amplitude-dependent plasticity, spike timing-dependent plasticity, as well as spike number-dependent plasticity. A consumption of 64.8 pJ per spike was achieved as a result of the efficient carrier transfer pathway facilitated by the nanosheets composed of double hydroxides. In addition, the FET's linear detection region (with a coefficient <em>R</em><sup>2</sup>=0.811) encompassed atrazine concentrations ranging from 10 pg/mL to 0.1 μg/mL, thanks to its high surface area and significant transconductance. Therefore, this study presents a potential approach for achieving energy-efficient neuromorphic computing and high-performance synaptic devices.</p></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":null,"pages":null},"PeriodicalIF":5.4,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142144521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biomimetic hydrogel coatings for improving the corrosion resistance, hemocompatibility, and endothelial cell growth of the magnesium alloy 改善镁合金耐腐蚀性、血液相容性和内皮细胞生长的仿生水凝胶涂层

IF 5.4 2区医学

Colloids and Surfaces B: Biointerfaces Pub Date : 2024-09-03 DOI: 10.1016/j.colsurfb.2024.114204

{"title":"Biomimetic hydrogel coatings for improving the corrosion resistance, hemocompatibility, and endothelial cell growth of the magnesium alloy","authors":"","doi":"10.1016/j.colsurfb.2024.114204","DOIUrl":"10.1016/j.colsurfb.2024.114204","url":null,"abstract":"<div><p>The fast biodegradation and poor biocompatibility of Mg alloys in physiological environments are still the main problems restricting their application in cardiovascular stents. In this study, the hydrogel coatings (SBMA-AAM) with different proportions of methacryloyl ethyl sulfobetaine (SBMA) and acrylamide (AAM) were built on the surface of AZ31B magnesium alloy through ultraviolet (UV) polymerization. The corrosion degradation behavior, hemocompatibility, and endothelial cell (EC) growth performance of the samples were studied in detail. The findings revealed that the uniform and dense SBMA-AAM coatings could significantly enhance the corrosion resistance. In addition, the hydrogel coatings showed excellent hydrophilicity, which increased the albumin adsorption while inhibiting the fibrinogen adsorption, and thus reduced the platelet adhesion and activation and hemolysis rate, accordingly significantly enhancing their anticoagulant performance. Furthermore, SBMA-AAM hydrogel coating promoted the EC adhesion and proliferation and the vascular endothelial growth factor (VEGF) and nitric oxide (NO) secretion of ECs, which is conducive to promoting endothelialization. When the concentration ratio of SBMA and AAM was 1: 2, the modified magnesium alloy showed the best corrosion resistance and biocompatibility. Therefore, the SBMA-AAM hydrogel coating could effectively regulate the corrosion degradation performance and biocompatibility of Mg alloys, laying a foundation for the application of Mg alloys in cardiovascular stents.</p></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":null,"pages":null},"PeriodicalIF":5.4,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142137337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Glutathione-responsive biodegradable nanohybrid for cancer photoacoustic imaging and gas-assisted photothermal therapy 用于癌症光声成像和气体辅助光热疗法的谷胱甘肽响应型生物可降解纳米杂化物。

IF 5.4 2区医学

Colloids and Surfaces B: Biointerfaces Pub Date : 2024-09-03 DOI: 10.1016/j.colsurfb.2024.114205

{"title":"Glutathione-responsive biodegradable nanohybrid for cancer photoacoustic imaging and gas-assisted photothermal therapy","authors":"","doi":"10.1016/j.colsurfb.2024.114205","DOIUrl":"10.1016/j.colsurfb.2024.114205","url":null,"abstract":"<div><p>Photothermal therapy (PTT), particularly in the near-infrared-II (NIR-II) range, has attracted widespread attention over the past years. However, the accompanied inflammatory responses can result in undesirable side effects and contribute to treatment ineffectiveness. Herein, we introduced a novel biodegradable nanoplatform (CuS/HMON-PEG) capable of PTT and hydrogen sulfide (H<sub>2</sub>S) generation, aimed at modulating inflammation for improved cancer treatment outcomes. The embedded ultrasmall copper sulphide (CuS) nanodots (1–2 nm) possessed favorable photoacoustic imaging (PAI) and NIR-II photothermal capabilities, rendering CuS/HMON-PEG an ideal phototheranostic agent. Upon internalization by 4T1 cancer cells, the hollow mesoporous organosilica nanoparticle (HMON) component could react with the overproduced glutathione (GSH) to produce H<sub>2</sub>S. In addition to the anticipated photothermal tumor ablation and H<sub>2</sub>S-induced mitochondrial dysfunction, the anti-inflammatory regulation was also been demonstrated by the downregulation of tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), and interleukin-1beta (IL-1β). More importantly, the modulation of inflammation also promoted wound healing mediated by PTT. This work not only presents a H<sub>2</sub>S-based nanomodulator to boost NIR-II PTT but also provides insights into the construction of novel organic/inorganic hybrid nanosystems.</p></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":null,"pages":null},"PeriodicalIF":5.4,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142144525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Injectable dual drug-loaded thermosensitive liposome-hydrogel composite scaffold for vascularised and innervated bone regeneration 用于血管和神经骨再生的可注射双药物热敏脂质体-水凝胶复合支架。

IF 5.4 2区医学

Colloids and Surfaces B: Biointerfaces Pub Date : 2024-09-03 DOI: 10.1016/j.colsurfb.2024.114203

{"title":"Injectable dual drug-loaded thermosensitive liposome-hydrogel composite scaffold for vascularised and innervated bone regeneration","authors":"","doi":"10.1016/j.colsurfb.2024.114203","DOIUrl":"10.1016/j.colsurfb.2024.114203","url":null,"abstract":"<div><p>Adequate blood supply and thorough innervation are essential to the survival of tissue-engineered bones. Though great progress has been created in the application of bone tissue engineering technology to bone defect repair, many challenges remain, such as insufficient vascularisation and deficient innervation in newly regenerated bone. In the present study, we addressed these challenges by manipulating the bone regeneration microenvironment in terms of vascularisation and innervation. We used a novel injectable thermosensitive liposome-hydrogel composite scaffold as a sustained-release carrier for basic fibroblast growth factor (bFGF, which promotes angiogenesis and neurogenic differentiation) and dexamethasone (Dex, which promotes osteogenic differentiation). In vitro biological assessment demonstrated that the composite scaffold had sufficient cell compatibility; it enhanced the capacity for angiogenesis in human umbilical vein endothelial cells, and the capacity for neurogenic/osteogenic differentiation in human bone marrow mesenchymal stem cells. Moreover, the introduction of bFGF/Dex liposome-hydrogel composite scaffold to bone defect sites significantly improved vascularisation and innervated bone regeneration properties in a rabbit cranial defect model. Based on our findings, the regeneration of sufficiently vascularised and innervated bone tissue through a sustained-release scaffold with excellent injectability and body temperature sensitivity represents a promising tactic towards bone defect repair.</p></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":null,"pages":null},"PeriodicalIF":5.4,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142144527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cu0-based nanoparticles boost anti-tumor efficacy via synergy of cuproptosis and ferroptosis enhanced by cuproptosis-induced glutathione synthesis disorder 铜氧化物纳米粒子通过铜氧化物诱导的谷胱甘肽合成障碍增强了铜氧化物和铁氧化物的协同作用，从而提高了抗肿瘤疗效。

IF 5.4 2区医学

Colloids and Surfaces B: Biointerfaces Pub Date : 2024-09-03 DOI: 10.1016/j.colsurfb.2024.114196

{"title":"Cu0-based nanoparticles boost anti-tumor efficacy via synergy of cuproptosis and ferroptosis enhanced by cuproptosis-induced glutathione synthesis disorder","authors":"","doi":"10.1016/j.colsurfb.2024.114196","DOIUrl":"10.1016/j.colsurfb.2024.114196","url":null,"abstract":"<div><p>Apoptotic resistance of tumor often leads to poor efficacy from mono-therapy based on apoptosis. Cuproptosis, a new type of non-apoptotic cell death related to mitochondrial dysfunction, can alter metabolism and enhance ferroptosis, providing a promising strategy for effective synergistic cancer treatment. In this work, Cu<sup>0</sup>-based nanoparticles (denoted as HA-ZCu) were successfully developed to improve anti-tumor efficacy by combining cuproptosis with enhanced ferroptosis, which was achieved by cuproptosis-induced glutathione synthesis disorder. <em>In vitro</em> studies revealed that HA-ZCu effectively induced cuproptosis and ferroptosis in HepG2 cells. Moreover, HA-ZCu induced mitochondrial dysfunction and decreased intracellular adenosine triphosphate (ATP), glutamate, and glutathione, demonstrating the effective synergy. <em>In vivo</em> studies further approved the synergistic therapeutic efficacy of HA-ZCu, where the inhibition rate of tumor growth reached 83.2 %. This work represents the first example of enhanced anti-tumor efficacy via cuproptosis and ferroptosis synergy through cuproptosis-induced glutathione synthesis disorder.</p></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":null,"pages":null},"PeriodicalIF":5.4,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142144522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fabrication of albumin-Ti3C2 MXene quantum dots-based nanohybrids for breast cancer imaging and synergistic photo/chemotherapeutics 制备基于白蛋白-Ti3C2 MXene 量子点的纳米混合物，用于乳腺癌成像和协同光/化学治疗。

IF 5.4 2区医学

Colloids and Surfaces B: Biointerfaces Pub Date : 2024-09-03 DOI: 10.1016/j.colsurfb.2024.114207

{"title":"Fabrication of albumin-Ti3C2 MXene quantum dots-based nanohybrids for breast cancer imaging and synergistic photo/chemotherapeutics","authors":"","doi":"10.1016/j.colsurfb.2024.114207","DOIUrl":"10.1016/j.colsurfb.2024.114207","url":null,"abstract":"<div><p>Advancement in the development of new materials with theranostic and phototherapeutic potential along with receptiveness to external stimuli has been persistently inspiring oncology research. Herein, titanium carbide-based MXene quantum dots (FHMQDs) have been synthesized and modified to take advantage of stimuli-responsive behavior and target specificity for breast cancer cells. With a size of around 3 nm, the developed FHMQDs demonstrate high fluorescent emission at around 460 nm. With ∼90 % encapsulation efficiency of doxorubicin (DOX), the developed system also offers rapid DOX release behavior when encountering an acidic pH (5.4). Further, the <em>in vitro</em> assessment of the developed FHMQDs on MDA-MB 231 breast cancer cells presents excellent target specificity to cancer cells which was reflected by its high cytotoxicity against cancer cells. Additionally, the outstanding photodynamic efficiency of FHMQDs due to excessive Reactive Oxygen Species (ROS) generating ability along with apoptosis promoting capability of FHMQDs in cancer cells demonstrates a synergistic approach in cancer theranostics. Encouragingly, the fabricated FHMQDs also exhibited fluorescent labelling and bioimaging capacity which makes it an incredible platform that ensures theranostic excellence in breast cancer research.</p></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":null,"pages":null},"PeriodicalIF":5.4,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142144524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances in nanotherapeutics for tumor treatment by targeting calcium overload 针对钙超载治疗肿瘤的纳米疗法取得进展

IF 5.4 2区医学

Colloids and Surfaces B: Biointerfaces Pub Date : 2024-09-02 DOI: 10.1016/j.colsurfb.2024.114190

{"title":"Advances in nanotherapeutics for tumor treatment by targeting calcium overload","authors":"","doi":"10.1016/j.colsurfb.2024.114190","DOIUrl":"10.1016/j.colsurfb.2024.114190","url":null,"abstract":"<div><p>Traditional antitumor strategies are facing challenges such as low therapeutic efficacy and high side effects, highlighting the significance of developing non-toxic or low-toxic alternative therapies. As a second messenger, calcium ion (Ca<sup>2+</sup>) plays an important role in cellular metabolism and communication. However, persistent Ca<sup>2+</sup> overload leads to mitochondrial structural and functional dysfunction and ultimately induced apoptosis. Therefore, an antitumor strategy based on calcium overload is a promising alternative. Here, we first reviewed the classification of calcium-based nanoparticles (NPs) for exogenous Ca<sup>2+</sup> overload, including calcium carbonate (CaCO<sub>3</sub>), calcium phosphate (CaP), calcium peroxide (CaO<sub>2</sub>), and hydroxyapatite (HA), calcium hydroxide, etc. Next, the current endogenous Ca<sup>2+</sup> overload strategies were summarized, including regulation of Ca<sup>2+</sup> channels, destruction of membrane integrity, induction of abnormal intracellular acidity and oxidative stress. Due to the specificity of the tumor microenvironment, it is difficult to completely suppress tumor development with monotherapy. Therefore, we reviewed the progress based on mitochondrial Ca<sup>2+</sup> overload, which improved the treatment efficiency by combining photothermal therapy (PTT), photodynamic therapy (PDT), chemodynamic therapy (CDT), sonodynamic therapy (SDT), immunogenic cell death (ICD) and gas therapy. We further explored in detail the advantages and promising new targets of this combination antitumor strategies to better address future opportunities and challenges.</p></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":null,"pages":null},"PeriodicalIF":5.4,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142129928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhanced-permeability delivery system for hydroxyl radical-responsive NIR-II fluorescence-monitored thrombolytic therapy 用于羟基自由基响应型近红外-II 荧光监测溶栓疗法的增强渗透输送系统。

IF 5.4 2区医学

Colloids and Surfaces B: Biointerfaces Pub Date : 2024-09-02 DOI: 10.1016/j.colsurfb.2024.114193

{"title":"Enhanced-permeability delivery system for hydroxyl radical-responsive NIR-II fluorescence-monitored thrombolytic therapy","authors":"","doi":"10.1016/j.colsurfb.2024.114193","DOIUrl":"10.1016/j.colsurfb.2024.114193","url":null,"abstract":"<div><p>Pathological thrombus can cause serious acute diseases that present a significant threat to human health, such as myocardial infarction and stroke. Challenges remain in achieving effective thrombolysis and real-time monitoring of therapeutic effects while minimizing side effects. Herein,a multifunctional nanoplatform (TG-OPDEA@UK/MnO<sub>2</sub>-H1080) with enhanced thrombus-permeability was developed to monitor the therapeutic effect of antioxidant-thrombolysis by hydroxyl radical-responsive NIR-II fluorescence imaging. The polyzwitterion poly (oxidized N,N-Diethylaminoethyl methacrylate-<em>co</em>-n-butyl methacrylate) (OPDEA) was prepared as the matrix of nanoparticles to simultaneously loading urokinase (UK) and MnO<sub>2</sub> QDs, as well as NIR-II fluorescent molecule, H-1080. Subsequently, the fibrin targeted peptide CREKA was modified on the surface of the nanoparticles. OPDEA exhibits efficient loading capacity while endowing nanoparticles with the ability to effectively increased penetration depth of UK by 94.1 % into the thrombus, for extensive thrombolysis and fluorescence monitoring. The loaded UK exhibited good thrombolytic effect and greatly reduced the risk of bleeding by 82.6 %. TG-OPDEA@UK/MnO<sub>2</sub>-H1080 showed good thrombolytic efficacy and specific thrombus monitoring in the mouse carotid artery thrombosis model induced by ferric chloride (FeCl<sub>3</sub>). This work prepares a nanoplatform for thrombolytic therapy and real-time efficacy assessment based on an independent externally forced thrombus penetration delivery strategy.</p></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":null,"pages":null},"PeriodicalIF":5.4,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142144523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

3D chitosan scaffolds loaded with ZnO nanoparticles for bone tissue engineering 用于骨组织工程的负载氧化锌纳米颗粒的三维壳聚糖支架

IF 5.4 2区医学

Colloids and Surfaces B: Biointerfaces Pub Date : 2024-09-02 DOI: 10.1016/j.colsurfb.2024.114199

{"title":"3D chitosan scaffolds loaded with ZnO nanoparticles for bone tissue engineering","authors":"","doi":"10.1016/j.colsurfb.2024.114199","DOIUrl":"10.1016/j.colsurfb.2024.114199","url":null,"abstract":"<div><p>Bone defect has always been a difficult problem in clinical work. According to the current research results, tissue engineered scaffolds with a single function, structure, and composition are not sufficient to repair complex bone defects. In this work, a three-dimensional (3D) chitosan degradable composite scaffold loaded with zinc oxide (ZnO) was constructed, and the effect of ZnO content on scaffold performance and osteogenesis was explored. The 3D composite scaffold was prepared by freeze-drying technology. The microstructure, porosity, degradation performance, release performance, swelling performance, cytotoxicity, cell adhesion and osteogenic ability of ZnO nanoparticles and chitosan (ZnONPs/CS) composite scaffolds were measured. The results show that an appropriate amount of ZnO may be helpful to regulate the stability and degradation characteristics of the scaffold to a certain extent. Moreover, the composite scaffold could release ZnO into the simulated body fluid environment. The appropriate amount of ZnO helps to promote the proliferation, adhesion, and osteogenic differentiation of MC3T3-E1 cells. At a ZnO content of 3 wt%, both in vitro and vivo results showed relatively optimal biocompatibility and bioactivity of the scaffolds. This work could at least provide some positive insights for the selection of ZnO dosage, construction of chitosan-based 3D scaffolds, tissue engineering applications, and clinical treatment.</p></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":null,"pages":null},"PeriodicalIF":5.4,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142129929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0