Colloids and Surfaces B: Biointerfaces最新文献

{"title":"Oxygen-boosted nanodrug for amplified ferroptosis-photodynamic immunotherapy together with PD-1 checkpoint blockade against triple-negative breast cancer","authors":"Zhirong Yang ,&nbsp;Lingli Deng ,&nbsp;Zhenhong Pan ,&nbsp;Xiaoyang Wang ,&nbsp;Li Lin ,&nbsp;Yaqi Fang ,&nbsp;Yinxing Huang ,&nbsp;Xianquan Feng ,&nbsp;Xi Chen","doi":"10.1016/j.colsurfb.2025.114963","DOIUrl":"10.1016/j.colsurfb.2025.114963","url":null,"abstract":"<div><div>While photodynamic therapy (PDT) may augment immune checkpoint blockade in triple-negative breast cancer (TNBC), its effectiveness is constrained by tumor hypoxia and suboptimal immune activation. To address these challenges, an innovative nanodrug (HV NPs) has been developed for the targeted delivery of the photosensitizer verteporfin and hemin, utilizing human serum albumin as a delivery vehicle. The catalase-like activity of hemin alleviates the hypoxic conditions in the tumor microenvironment and boosts PDT. The HV NPs, when activated by a 635 nm laser, induce apoptosis and ferroptosis in tumor cells and facilitate the release of tumor-associated debris, which triggers immunogenic cell death and enhance tumor immunogenicity. Meanwhile, modulation of the hypoxic tumor microenvironment attenuates immunosuppressive cell infiltration, thereby enhancing antitumor immunity. This systemic immune response can be further enhanced by PD-1 blockade, thereby inhibiting both primary tumors and lung metastasis. Collectively, our study indicates that HV NPs-mediated oxygen-boosted PDT represents a promising strategy to enhance the efficacy of PD-1 checkpoint blockade immunotherapies in TNBC.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"255 ","pages":"Article 114963"},"PeriodicalIF":5.4,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144672531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Drug loaded hydrogel nanoparticles with long retention in tumor and multi drug co delivery for melanoma treatment","authors":"Jiafan Bai ,&nbsp;Yuhao Liu ,&nbsp;Xiangli Chen ,&nbsp;Linyu Wang ,&nbsp;Jie Shi ,&nbsp;Hongyan Liu ,&nbsp;Wenzhen Peng ,&nbsp;Yuancong Zhao ,&nbsp;Jie Weng ,&nbsp;Wei Zhi ,&nbsp;Jianxin Wang","doi":"10.1016/j.colsurfb.2025.114962","DOIUrl":"10.1016/j.colsurfb.2025.114962","url":null,"abstract":"<div><div>This study aims to address the issue of immune clearance and inaccurate targeting of drug-loaded nanoparticles during intravenous injection, which may lead to partial drug release into non target tissues or organs, damage to normal tissues and low drug utilization. Herein, multi-drug co-delivery nanoparticles with intratumoral long retention capability were developed for melanoma treatment. This study adopted a dual drug loading strategy of curcumin and dexamethasone and designed a drug-loaded nano-system based on polyglutamic acid and caffeic acid. The results indicate that the introduction of caffeic acid endowed nanoparticles with the property of long-term retention in melanoma sites, while also obtaining a certain inhibitory effect on melanoma growth and good antioxidant properties. To make nanoparticles more stable in water environment, we employed esterification reaction to introduce ester bond to enhance the water resistance of nanoparticles, thus giving them stability in water environment. Two drugs with different hydrophilicity were co-loaded into nanoparticles through grafting and π-π stacking. The experimental results in vitro and in vivo indicate that such strategy and design have achieved long-term retention of nanoparticles at tumor site, and meanwhile allow nanoparticles to effectively inhibit the growth and metastasis of tumor cells, achieving ideal therapeutic effects on melanoma treatment.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"255 ","pages":"Article 114962"},"PeriodicalIF":5.4,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144665573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimized synthesis and characterization of highly reproducible carbon dots for bioimaging applications","authors":"D. Manno ,&nbsp;M.M. Orlando ,&nbsp;A. Gabriele ,&nbsp;G.G. Carbone ,&nbsp;A. Buccolieri ,&nbsp;L. Calcagnile ,&nbsp;A. Bibi ,&nbsp;D. De Benedictis ,&nbsp;G. Capitanio ,&nbsp;D. De Rasmo ,&nbsp;A. Signorile ,&nbsp;G. Giancane ,&nbsp;A. Serra","doi":"10.1016/j.colsurfb.2025.114951","DOIUrl":"10.1016/j.colsurfb.2025.114951","url":null,"abstract":"<div><div>In this paper, we present the optimization of synthesis parameters to obtain highly stable fluorescent Carbon Dots (CDs). This was achieved through a multidisciplinary approach that combined systematic variation of synthesis conditions with comprehensive characterization techniques. Spectroscopic analyses, including absorbance and fluorescence measurements, along with transmission electron microscopy, confirmed the uniform morphology and distinctive optical emission of the CDs. Additionally, electron energy loss spectroscopy provided valuable insights into their chemical composition, while high-resolution transmission electron microscopy (HRTEM) revealed structural order at the nanometer scale. Among the synthesized CDs, those exhibiting the most promising optical and physicochemical properties were further tested to assess their cellular imaging potential, cytocompatibility, and non-toxicity. The data showed that CDs were cytocompatible and can permeate the cell membrane localizing in the cells. Notably, these CDs showed the ability to targeting mitochondria, underscoring their potential for analyses of mitochondrial structure and function in different physiological and pathological conditions.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"255 ","pages":"Article 114951"},"PeriodicalIF":5.4,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144666073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanozyme-synbiotics to improve iron-deficiency anemia","authors":"Aimin Wu ,&nbsp;Xiangyuan Li ,&nbsp;Zean Kuang ,&nbsp;Ke Gu ,&nbsp;Yuheng Luo ,&nbsp;Daiwen Chen ,&nbsp;Xianxiang Wang","doi":"10.1016/j.colsurfb.2025.114960","DOIUrl":"10.1016/j.colsurfb.2025.114960","url":null,"abstract":"<div><div>Iron deficiency anemia (IDA) affects approximately one-third of the global population, and conventional treatments often face challenges such as poor absorption and adverse effects. This study investigated the therapeutic potential of <em>Bacteroides ovatus</em> (BO) and its synergistic combination with MIL-101(CuFe) nanozyme for IDA. The results demonstrated that BO significantly enhanced intestinal iron absorption by upregulating the expression of the duodenal iron transporter ZIP14 and ferroportin (Fpn). Concurrently, BO improved iron transport and storage by upregulating the protein expression of hepatic transferrin receptor 1 (TFR1) and ferritin subunits FTH/L. Furthermore, BO significantly downregulated the protein expression of hepatic hepcidin, thereby maintaining Fpn function. Subsequently, synthesized MIL-101(CuFe) nanozyme, exhibiting prebiotic properties, was found to significantly promote BO growth (by more than 3-fold). The combination of BO and MIL-101(CuFe) formed the CuFeBO \"nanozyme-synbiotics\", which substantially alleviated IDA by synergistically improving iron absorption (Fpn), transport (TFR1), and storage (FTH/L). In conclusion, this study elucidates the mechanism by which BO and the CuFeBO nanozyme-symbiont effectively alleviate IDA through multi-targeted, precise modulation of iron absorption, transport, and storage pathways. This synergistic strategy successfully overcomes the limitations of low absorption rates and significant side effects associated with conventional iron therapies, providing a crucial theoretical foundation and broad application prospects for developing novel, efficient, and safer treatments for IDA.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"255 ","pages":"Article 114960"},"PeriodicalIF":5.4,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144656304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Small-angle scattering characterization of magnetosomes from Magnetospirillum gryphiswaldense MSR-1","authors":"Adnan Khan ,&nbsp;Paolo Moretti ,&nbsp;Valentina Notarstefano ,&nbsp;Paolo Mariani ,&nbsp;Najet Mahmoudi ,&nbsp;Stephen King ,&nbsp;Gouranga Manna ,&nbsp;Francesco Vita ,&nbsp;Oriano Francescangeli ,&nbsp;Matteo Fanelli ,&nbsp;Silvia Illuminati ,&nbsp;Francesca Ripanti ,&nbsp;Francesco Spinozzi","doi":"10.1016/j.colsurfb.2025.114833","DOIUrl":"10.1016/j.colsurfb.2025.114833","url":null,"abstract":"<div><div>Magnetosomes are biogenic nanomaterials synthesized by magnetotactic bacteria, with promising applications in drug delivery and environmental remediation. This study offers a thorough characterization of magnetosomes isolated from <em>Magnetospirillum gryphiswaldense</em> strain MSR-1, cultivated under various conditions. Laboratory techniques, including dynamic light scattering, atomic force microscopy, scanning electron microscopy, infrared spectroscopy, and X-ray diffraction were employed to analyze the chemical and physical properties of the samples and to verify their crystal structure. Further structural investigations were carried out by using small-angle neutron and X-ray scattering and data were analyzed through a novel model that allowed for a quantitative analysis of magnetosomes, detailing their iron oxide core, lipid membrane, and associated proteins. This research advances our understanding of magnetosome structure and functionality, demonstrating the potential to tailor bacterial growth conditions in order to address optimal characteristics for each specific application and, thus, laying the groundwork for a broad spectrum of future applications.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"255 ","pages":"Article 114833"},"PeriodicalIF":5.4,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144656305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimizing efficacy: Hyaluronic acid liposomes encapsulating minoxidil for enhanced transdermal delivery and treatment of androgenetic alopecia","authors":"Ziyi Zhao ,&nbsp;Yue Wang ,&nbsp;Hui Xing ,&nbsp;Yucheng Wang ,&nbsp;Kai Lv ,&nbsp;Xiangjun Pan ,&nbsp;Tuo Chen ,&nbsp;Yunfeng Hu ,&nbsp;Guowei Li ,&nbsp;Dong Ma","doi":"10.1016/j.colsurfb.2025.114956","DOIUrl":"10.1016/j.colsurfb.2025.114956","url":null,"abstract":"<div><div>Minoxidil (Mi) is currently one of the most commonly used drugs for the treatment of hair loss in clinical settings. It works by accelerating blood flow around the hair follicles, enhancing local oxygen and nutrient supply, thereby promoting hair growth. However, traditional formulations of Mi have a short residence time on the skin, are prone to causing allergic reactions, scaling, and may even induce systemic hypertrichosis as side effects. This highlights the urgent need for the development of more efficient and safer delivery systems to improve its therapeutic efficacy. In previous studies, our team developed a high molecular weight hyaluronic acid-based delivery platform (HL) with excellent skin penetration, anti-inflammatory properties, and tissue repair capabilities. In this study, we used the HL delivery material as a carrier for Mi and developed a Mi delivery system with high drug encapsulation efficiency and good biological safety—HL@Mi. This delivery system encapsulates Mi within HL using techniques such as reverse evaporation, high-speed homogenization, and microjet high-pressure methods. Fluorescent labeling and high-performance liquid chromatography (HPLC) were employed to confirm that HL@Mi significantly enhanced the skin penetration and retention of Mi, effectively improving the local bioavailability of Mi. <em>In vitro</em> experiments, HL@Mi significantly reduced the cytotoxicity of Mi, while optimizing the hair follicle microenvironment by promoting angiogenesis and regulating the expression of IL-6, MMP3, and β-catenin genes associated with hair follicle function. In an established androgenetic alopecia animal model, HL@Mi significantly downregulated the expression of inflammatory factors such as IL-6, TNF-α, and TGF-β1 in the skin, while upregulating Ki67 expression in the hair follicle tissue, thereby accelerating hair growth and effectively improving hair loss symptoms. Moreover, HL@Mi exhibited good biocompatibility and safety. In summary, HL@Mi, as a novel transdermal delivery system, not only provides a more efficient and safer clinical alternative for Mi in the treatment of androgenetic alopecia, but also offers valuable technical insights for other local drug delivery strategies.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"255 ","pages":"Article 114956"},"PeriodicalIF":5.4,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144665575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Imitating the function of glucose oxidase by 3-aminopropyltriethoxysilane modified Cu2O for selective electrochemical glucose sensing","authors":"Chenhuinan Wei ,&nbsp;Yang Zhang ,&nbsp;Qijun Cheng ,&nbsp;Rulin Li ,&nbsp;Rui Xiong ,&nbsp;Shengfu Wang","doi":"10.1016/j.colsurfb.2025.114957","DOIUrl":"10.1016/j.colsurfb.2025.114957","url":null,"abstract":"<div><div>Selective detection of glucose in complex biological matrices remains a major challenge for non-enzymatic electrochemical sensors due to interference from co-existing species such as ascorbic acid (AA) and uric acid (UA). Herein, we developed an amine-functionalized Cu₂O electrocatalyst (Cu₂O-NH₂), fabricated via a facile silanization strategy using 3-aminopropyltriethoxysilane (APTES) on Cu₂O octahedron. The introduction of surface amine group effectively suppresses the interference signals of AA and UA by 34.78 % and 46.94 %, respectively, while boosting the glucose oxidation response by 1.8-fold compared with pristine Cu₂O. The resulting Cu₂O-NH₂ sensor showed a wide linear range of 0.00089–1.27 mM with a high sensitivity of 1.6001 mA cm⁻² mM⁻¹, and a low detection limit of 0.89 μM, along with the excellent reproducibility and long-term stability. This customized Cu₂O-NH₂ material ultimately exhibited accurate measurement in actual human serum. Experimental studies and theoretical calculations reveal that the amine groups selectively inhibit the adsorption of AA and UA while accelerating the glucose oxidation kinetics, thus imitating the glucose oxidase-like function. Moreover, the universality of this APTES functionalization strategy was validated across other metal oxides, highlighting its potential to address the selectivity limitations of non-enzymatic sensors and offering new opportunities for the development of non-enzymatic biosensing platforms based on micro- and nano-structured materials.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"255 ","pages":"Article 114957"},"PeriodicalIF":5.4,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144666074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hydrophobicity of apple skin: Effects of waxing and washing on interfacial interactions with viruses. A comparative U.S.-France-China study","authors":"Xunhao Wang ,&nbsp;Katy Foss ,&nbsp;Atef Choudhury ,&nbsp;Xuanfeng Wang ,&nbsp;Julie Mendret ,&nbsp;Geoffroy Lesage ,&nbsp;Samuel D. Snow ,&nbsp;Jamie Kober ,&nbsp;Peng Chen ,&nbsp;Volodymyr V. Tarabara","doi":"10.1016/j.colsurfb.2025.114953","DOIUrl":"10.1016/j.colsurfb.2025.114953","url":null,"abstract":"<div><div>Surface properties of apples, and the hydrophobicity of their skin in particular, affect the shelf life and marketability of apples. Surface characteristics of the skin are also of critical importance for securing microbiological safety of this common consumer item. The present work explores how pre-sale waxing in a packaging facility as well as washing and storage by consumers influence the surface energy of apples and assesses the impact of such treatments on pathogen adhesion to the apple surface. Based on contact angle measurements, the surface energy of apples from different geographical regions was quantified and mapped to specific fruit handling scenarios that included extended storage as well as possible waxing and washing. Experimental data were used as to compute the free energy of interfacial interaction between apple skin and two pathogenic viruses of significant relevance for public health - human respiratory syncytial virus (HRSV) and human adenovirus 5 (HAdV5). For the U.S. samples of Fuji apples, washing increased apple skin hydrophobicity for both apples that were waxed (ΔG decrease from –60.3 mJ/m² to −84.4 mJ/m²) and, even more, for unwaxed apples (ΔG decrease from –53.8 mJ/m² to −89.5 mJ/m²). Hydrophobicity of waxed apples also increased (steady decrease in ΔG from –58.0 mJ/m² to –94.7 mJ/m²) over 9 days of shelf storage. A comparative analysis of apples from the U.S., China, and France revealed notable differences in the effects of waxing and washing: waxed but unwashed apples are hydrophobic in both U.S. (–60.3 mJ/m²) and China (–76.5 mJ/m²), while in France, the same treatment results in a hydrophilic surface (34.9 mJ/m²). As sampled (i. e. neither waxed, nor washed), apples from all three countries are moderately hydrophobic, likely due to natural wax. This study provides insights into the interplay between surface treatments, shelf life, and virus-apple interaction, aiming to improve food safety protocols and storage practices for apples.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"255 ","pages":"Article 114953"},"PeriodicalIF":5.4,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144672532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Size-adjustable nanoparticles co-target macrophages and endothelial cells for enhanced atherosclerosis therapy","authors":"Yiping Deng ,&nbsp;Xin Deng ,&nbsp;Yao Li ,&nbsp;Ji Tian ,&nbsp;Mengxi Wu ,&nbsp;Jun Tang ,&nbsp;Xiaoya Liang ,&nbsp;Xi Yang ,&nbsp;Xinghui He ,&nbsp;Yilin Liu ,&nbsp;Zihan Liu ,&nbsp;Xiangyu Zhou ,&nbsp;Tao Li ,&nbsp;Chunhong Li","doi":"10.1016/j.colsurfb.2025.114952","DOIUrl":"10.1016/j.colsurfb.2025.114952","url":null,"abstract":"<div><div>In the pathological process of atherosclerosis (AS), macrophages and dysfunctional endothelial cells form an inflammation-injury axis through inflammatory amplification, oxidative stress, and interaction of signaling pathways. The synergistic targeted intervention of the two cells is the key to improve the plaque microenvironment and achieve disease reversal. However, the lipid core under the vascular intima hinders the penetration of large-sized nanoparticles into dysfunctional macrophages in the plaque, making it hard to block the vicious circle between macrophages and endothelial cells. To this end, we engineered a size-adjustable nanoparticle (CS/P_Arg@Cur-HSA), which was consisted of a small-sized curcumin (Cur)-human serum albumin (HSA) (Cur-HSA) complex as the core, and its surface was coated with cell-penetrating peptide poly(arginine) (P_Arg), further encapsulating it with chondroitin sulfate (CS) as a targeting ligand. <em>In vitro</em> experiments demonstrated that CS/P_Arg@Cur-HSA significantly enhanced targeting ability to macrophages, inhibited the polarization of macrophages to the pro-inflammatory phenotype, and reduced the formation of foam cells induced by oxidized low-density lipoprotein (ox-LDL). While it also enhanced the anti-inflammatory capacity of endothelial cells and improved endothelial function. <em>In vivo</em> evaluation revealed that the preparation significantly reduced the plaque accumulation, ameliorated intraplaque lipid deposition and inflammatory cell infiltration, and retarded disease progression through synergistic modulation. This study provided a new strategy for the application of size-adjustable nano-drug delivery systems in AS therapy.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"255 ","pages":"Article 114952"},"PeriodicalIF":5.4,"publicationDate":"2025-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144631871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nucleic acid-based nanogels for drug delivery：From construction strategies to intelligent applications","authors":"Zijian Zhao ,&nbsp;Fei Sun ,&nbsp;Hongli Yu ,&nbsp;Bing Li ,&nbsp;Xianwen Wang ,&nbsp;Yong Sun ,&nbsp;Jianqin Yan","doi":"10.1016/j.colsurfb.2025.114948","DOIUrl":"10.1016/j.colsurfb.2025.114948","url":null,"abstract":"<div><div>Nanogels are nanoscale hydrogel particles, formed through intramolecular or intermolecular cross-linking. They serve as versatile carriers in drug delivery due to their high stability, excellent biocompatibility, and intelligent responsiveness to environmental stimuli. Nucleic acid-based nanogels are of particular interest due to the unique characteristics of nucleic acids. Nucleic acid-based nanogels not only possess the properties and functionalities of nanomaterials and hydrogels, but also its excellent flexibility, stability, precise programmability and adjustability makes them shine in the biomedical field. In addition, functional nucleic acids, such as microRNA, small interfering RNA, i-motif nanostructures, etc., provide assistance for the construction of nucleic acid-based nanogels to provide additional stimulus response, molecular recognition, disease treatment potential, making them key participants in biomedical applications. Therefore, it is crucial to summarize the existing preparation strategies, biological properties and recent applications of nucleic acid-based nanogels, which can help to seek new directions for the development of nanocarriers. This review summarizes various synthesis strategies and drug delivery mechanisms of nucleic acid-based nanogels. It also discusses protective and functional modifications for intelligent nanogels, outlines their biomedical applications, and explores future development directions. It is anticipated that this review will facilitate the development of novel nucleic acid-based nanogels and bring new vitality to therapeutic interventions for a range of diseases.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"255 ","pages":"Article 114948"},"PeriodicalIF":5.4,"publicationDate":"2025-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144623650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}