Colloids and Surfaces B: Biointerfaces最新文献

Intraocular-microenvironment responsive fluorescent hydrogels in rhegmatogenous retinal detachment repair 眼内微环境反应性荧光水凝胶在孔源性视网膜脱离修复中的应用

IF 5.6 2区医学

Colloids and Surfaces B: Biointerfaces Pub Date : 2026-06-01 Epub Date: 2026-01-28 DOI: 10.1016/j.colsurfb.2026.115473

Yuzheng Zhou , Chunli Ma , Yibin Sun , Yuan Wu , Tongfeng Han , Yongqiang Xue , Guotai Li , Qihui Zhou , Zhaodong Du

{"title":"Intraocular-microenvironment responsive fluorescent hydrogels in rhegmatogenous retinal detachment repair","authors":"Yuzheng Zhou , Chunli Ma , Yibin Sun , Yuan Wu , Tongfeng Han , Yongqiang Xue , Guotai Li , Qihui Zhou , Zhaodong Du","doi":"10.1016/j.colsurfb.2026.115473","DOIUrl":"10.1016/j.colsurfb.2026.115473","url":null,"abstract":"<div><div>Rhegmatogenous retinal detachment (RRD) is a severe eye condition that can threaten vision without proper treatment. The primary treatment for RRD is vitrectomy, however, the postoperative requirement for a prone position, coupled with unsatisfactory retinal reattachment rates, presents a significant clinical challenge. Recent advancements in technology and material engineering have led to the development of specific biomaterials serving as retinal patches that can seal retinal breaks. Whereas, existing materials still face limitations including the need for specialized implantation instruments and complex surgical operations for certain materials, inadequate conformability to the eyeball due to relatively high material rigidity that impairs sealing performance, and poor biocompatibility. To overcome these difficulties, herein we introduce a novel fluorescent hydrogel composed of 4-arm-PEG-Mal and 4-arm-PEG-SH as a retinal sealant. This innovative material undergoes rapid gelation in response to the weakly alkaline intraocular environment following injury, enabling effective sealing of retinal breaks and the surrounding area. Furthermore, the hydrogel's inherent fluorescent property provides enhanced intraoperative visibility. Evaluated in a rabbit model of retinal detachment, the hydrogel demonstrated efficient therapeutic treatment in promoting RRD repair, while offering significant visual and surgical advantages. In conclusion, the retinal break-sealing hydrogel developed in this work presents a promising new strategy for the treatment of RRD, with considerable potential for clinical translation.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"262 ","pages":"Article 115473"},"PeriodicalIF":5.6,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146076994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploration of sub-cellular responses for the evaluation of the laser mediated tumor ablation via Raman spectroscopic platform using green synthesized gold nanostars 利用绿色合成金纳米星在拉曼光谱平台上探索激光介导肿瘤消融的亚细胞反应

IF 5.6 2区医学

Colloids and Surfaces B: Biointerfaces Pub Date : 2026-06-01 Epub Date: 2026-01-25 DOI: 10.1016/j.colsurfb.2026.115472

BS Unnikrishnan , GU Preethi , PT Sujai , Kaustabh Kumar Maiti , TT Sreelekha

{"title":"Exploration of sub-cellular responses for the evaluation of the laser mediated tumor ablation via Raman spectroscopic platform using green synthesized gold nanostars","authors":"BS Unnikrishnan , GU Preethi , PT Sujai , Kaustabh Kumar Maiti , TT Sreelekha","doi":"10.1016/j.colsurfb.2026.115472","DOIUrl":"10.1016/j.colsurfb.2026.115472","url":null,"abstract":"<div><div>Anisotropic gold nanoparticles with surface plasmon resonance (SPR) can generate heat upon exposure to laser light, which can then be utilised for photothermal therapy (PTT) in cancer treatment. In this study, we report the use of doxorubicin (DOX)-loaded immunomodulatory polysaccharide (PST001) coated anisotropic gold nanostars (AuNS@PST) as a theranostic carrier for photothermal-chemotherapy. AuNS@PST were prepared by green synthesis followed by doxorubicin encapsulation. The synthesized particles were characterized using UV–vis spectroscopy, DLS, FTIR and TEM. The heat dissipation of these nanoparticles was monitored in aqueous phantoms using 635 nm laser sources, which indicated the thermal rise from ambient temperature. The <em>in vitro</em> cytotoxicity analysis of AuNS@PST was done using the MTT assay in A549 cells. Significantly lower IC<sub>50</sub> value was observed for cells treated with DOX-loaded PST AuNSs when compared to DOX-alone treated cells. Similarly, DOX-loaded AuNS@PST had efficient photothermal-induced apoptosis exerted by the laser-irradiated nanoparticles. Changes in protein degradation and DNA fragmentation at the subcellular levels were observed in the Raman spectrum. Although supplementary perspectives are required in the proper investigation of laser-mediated cell death in cancer tissues, the current study discloses the emerging methodology to track apoptotic events in cancer tissues using the Raman scattering platform, even at the sub-cellular level.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"262 ","pages":"Article 115472"},"PeriodicalIF":5.6,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146049234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Copper-infused 13–93 bioactive glass inhibiting postoperative osteosarcoma recurrence and enhancing bone regeneration 铜注入13-93生物活性玻璃抑制术后骨肉瘤复发及促进骨再生

IF 5.6 2区医学

Colloids and Surfaces B: Biointerfaces Pub Date : 2026-06-01 Epub Date: 2026-01-27 DOI: 10.1016/j.colsurfb.2026.115475

Hao Gong , Zhengfeng Lu , Suming Wei , Yongjun Rui

{"title":"Copper-infused 13–93 bioactive glass inhibiting postoperative osteosarcoma recurrence and enhancing bone regeneration","authors":"Hao Gong , Zhengfeng Lu , Suming Wei , Yongjun Rui","doi":"10.1016/j.colsurfb.2026.115475","DOIUrl":"10.1016/j.colsurfb.2026.115475","url":null,"abstract":"<div><div>Osteosarcoma (OS)-induced bone abnormalities present a considerable clinical challenge due to elevated chances of recurrence and compromised repair, which significantly jeopardize patient survival. Contemporary bioactive glasses (BGs), notwithstanding their osteogenic potential, exhibit restricted anticancer efficacy. Therefore, It is essential to enhance the tumor-killing efficacy of BGs for usage as a filler in tumor-induced bone defects. Here, a copper (Cu)-doped 13–93BG (13–93BG-Cu) was synthesized and subsequently combined with chitosan to form the 13–93BG-Cu system. The rapid release of Cu ions (Cu<sup>2 +</sup>) during the initial stages of this system enhances the killing of tumor cells by cuproptosis, as intracellular Cu<sup>2+</sup> accumulation triggers the oxidative stress response within mitochondria, hence achieving anti-OS therapy. Subsequently, the sustained low-level release of Cu<sup>2+</sup> and bioactive ions collaboratively influences the activation and function of macrophage and stem cells, promoting bone defect healing. This study introduces a dual-action BG that simultaneously neutralizes the acidic tumor microenvironment and promotes cuproptosis, effectively preventing recurrence while facilitating bone healing via Cu<sup>2+</sup> gradient release.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"262 ","pages":"Article 115475"},"PeriodicalIF":5.6,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146076995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biomimetic red blood cell membrane–coated cerium metal–organic framework for multi-target synergistic therapy of Alzheimer’s disease 仿生红细胞膜包覆金属铈-有机框架多靶点协同治疗阿尔茨海默病

IF 5.6 2区医学

Colloids and Surfaces B: Biointerfaces Pub Date : 2026-06-01 Epub Date: 2026-01-23 DOI: 10.1016/j.colsurfb.2026.115464

Fengmei Yang , Yutong Chen , Yujiao Yan , Ruixin Zhao , Liran Deng , Die Tian , Meng Xie

{"title":"Biomimetic red blood cell membrane–coated cerium metal–organic framework for multi-target synergistic therapy of Alzheimer’s disease","authors":"Fengmei Yang , Yutong Chen , Yujiao Yan , Ruixin Zhao , Liran Deng , Die Tian , Meng Xie","doi":"10.1016/j.colsurfb.2026.115464","DOIUrl":"10.1016/j.colsurfb.2026.115464","url":null,"abstract":"<div><div>Pathological events in Alzheimer’s disease (AD) typically involve β-amyloid (Aβ) plaque deposition, metal ion dysregulation, oxidative stress elevation, and chronic neuroinflammation, making single-target therapies unsatisfactory. Here, we first report a biomimetic nanoplatform based on red blood cell membrane–coated cerium metal–organic frameworks (Ce-MOF-RBC) that enables multi-target synergistic intervention against AD. The Ce-MOF core exhibits potent antioxidant activity, efficiently scavenging reactive oxygen species (ROS) and restoring mitochondrial membrane potential, while its carboxylate ligands chelate Cu<sup>2 +</sup> with high efficiency (49.26 %) to inhibit Cu<sup>2+</sup>-induced Aβ fibrillation and disassemble preformed fibrils. Ce-MOF-RBC further modulates microglial phenotype, enhancing Aβ phagocytosis and reducing neuroinflammation. Importantly, RBC membrane functionalization markedly improves biological performance by prolonging systemic circulation, enhancing blood–brain barrier (BBB) penetration, and leveraging its intrinsic affinity for Aβ peptides to enrich Aβ. In vivo fluorescence imaging and brain cryosections showed that Ce-MOF-RBC achieved robust accumulation in the cortex and hippocampus, with brain fluorescence intensities 27.33-fold higher than free DiD. In the <em>C. elegans</em> AD model, Ce-MOF-RBC reduced Aβ plaque fluorescence by 32.54 %, lowered ROS levels by 45.72 %, improved chemotaxis performance (chemotaxis index increased from 34.24 % to 68.34 %), and delayed paralysis onset from 10 h to 15 h, demonstrating significant rescue of cognitive and motor deficits. In summary, these findings highlight the first demonstration of a small-sized, biomimetic Ce-MOF-RBC nanoplatform that integrates antioxidant, metal-chelating, anti-aggregation, and immunomodulatory functions, offering a promising strategy for comprehensive AD therapy.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"262 ","pages":"Article 115464"},"PeriodicalIF":5.6,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146048912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synergistic regeneration of cartilage and bone using synovial fluid-derived MSCs and exosomes: A novel therapeutic strategy for osteoarthritis 利用滑膜液来源的间充质干细胞和外泌体协同再生软骨和骨：骨关节炎的一种新的治疗策略

IF 5.6 2区医学

Colloids and Surfaces B: Biointerfaces Pub Date : 2026-06-01 Epub Date: 2026-01-28 DOI: 10.1016/j.colsurfb.2026.115482

Satish Kumar Vemuri , P. Pavan Kumar , Ravi Adusumalli , Uttam Kumar Neeredu , K. Murali Manohar , G.P.V. Subbaiah , A.V. Gurava Reddy , Lipi Pradhan , Rajkiran Reddy Banala , M. Indira Devi , Sudip Mukherjee

{"title":"Synergistic regeneration of cartilage and bone using synovial fluid-derived MSCs and exosomes: A novel therapeutic strategy for osteoarthritis","authors":"Satish Kumar Vemuri , P. Pavan Kumar , Ravi Adusumalli , Uttam Kumar Neeredu , K. Murali Manohar , G.P.V. Subbaiah , A.V. Gurava Reddy , Lipi Pradhan , Rajkiran Reddy Banala , M. Indira Devi , Sudip Mukherjee","doi":"10.1016/j.colsurfb.2026.115482","DOIUrl":"10.1016/j.colsurfb.2026.115482","url":null,"abstract":"<div><div>Osteoarthritis (OA) is the most common and progressive joint disorder, characterized by the slow breakdown of cartilage and the underlying bone. The leading cause of OA is age-related wear and tear of joint cartilage, often worsened by factors such as obesity, joint injuries, genetic predisposition, repetitive stress, and joint misalignment. Current medical interventions are limited in their ability to regenerate damaged tissues. While synovial fluid-derived mesenchymal stem cells (SF-MSCs) and their exosomes show distinct therapeutic promise, their combined efficacy remains largely unexplored. This study investigates their synergistic potential in a preclinical osteoarthritis model, which has been optimized for rapid deployment and field applicability in combat scenarios. A full-thickness cartilage defect model was established in Wistar rats (n = 30), divided into four groups: PBS control, SF-MSCs alone, exosomes alone, and a combination therapy group. Treatments were administered intra-articularly. The combination therapy resulted in an 85.3 % reduction in cartilage defect size and a 57.8 % increase in bone density by week 8. Histological analysis confirmed enhanced cartilage regeneration and extracellular matrix formation. qPCR data showed significant upregulation of osteogenic markers. This dual-platform, cell-free approach offers a minimally invasive and scalable therapy for combat-related joint injuries and osteoarthritis. Its combination of differentiation, paracrine signaling, and immunomodulatory mechanisms delivers superior regenerative efficacy.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"262 ","pages":"Article 115482"},"PeriodicalIF":5.6,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146076899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

SHED-exosome-functionalized degradable fibrous coatings: Immunomodulatory engineering of titanium implant interfaces shed -外泌体功能化可降解纤维涂层：钛种植界面的免疫调节工程

IF 5.6 2区医学

Colloids and Surfaces B: Biointerfaces Pub Date : 2026-06-01 Epub Date: 2026-01-27 DOI: 10.1016/j.colsurfb.2026.115479

Rui Wang , Yicheng Cheng , Hong Chen , Wenxi Shan , Youbei Qiao , Jiang Wu

{"title":"SHED-exosome-functionalized degradable fibrous coatings: Immunomodulatory engineering of titanium implant interfaces","authors":"Rui Wang , Yicheng Cheng , Hong Chen , Wenxi Shan , Youbei Qiao , Jiang Wu","doi":"10.1016/j.colsurfb.2026.115479","DOIUrl":"10.1016/j.colsurfb.2026.115479","url":null,"abstract":"<div><div>The host immune response critically determines the regeneration efficacy of peri-implant tissues. Exosomes derived from stem cells from human exfoliated deciduous teeth (SHED-Exo), enriched with bioactive components, demonstrate proven immunomodulatory capabilities. This study developed a composite structured coating system for loading and sustained-release delivery of SHED-Exo on titanium implants. The system integrates chitosan nanoparticles (CS-NPs) encapsulating SHED-Exo (CS@Exo NPs) within a Polylactic acid/polymalic acid (PLA/PMLA) electrospun nanofibrous membrane. Key findings revealed that: (1) CS-NPs maintained structural integrity and bioactivity of encapsulated SHED-Exo, enabling effective cellular internalization; (2) The composite coating comprising nanofibers and nanoparticles (PLA/PMLA/CS@Exo) demonstrated superior sustained-release performance, achieving continuous exosome delivery for over 30 days; (3) Released exosomes significantly promoted macrophage M2 polarization and anti-inflammatory cytokine secretion in vitro; (4) The nanofibrous coating exhibited excellent mechanical stability during simulated implantation and degradation characteristics. This dual nanoarchitecture establishes a robust platform for implant-surface functionalization, combining immunomodulation through bioactive exosome delivery with favorable degradation profiles.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"262 ","pages":"Article 115479"},"PeriodicalIF":5.6,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146076896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Controllable construction and corrosion control of MOFs membranes based multifunctional coatings on medical magnesium surfaces: A review 医用镁表面mof膜多功能涂层的可控结构与腐蚀控制研究进展

IF 5.6 2区医学

Colloids and Surfaces B: Biointerfaces Pub Date : 2026-06-01 Epub Date: 2026-01-28 DOI: 10.1016/j.colsurfb.2026.115477

Jiayu He, Yali Li, Xing Zhang, Aotian He, Chao Xiong, Luhong Sun, Xin Chen, Liang Liu, Yi Tu, Dong Zeng

{"title":"Controllable construction and corrosion control of MOFs membranes based multifunctional coatings on medical magnesium surfaces: A review","authors":"Jiayu He, Yali Li, Xing Zhang, Aotian He, Chao Xiong, Luhong Sun, Xin Chen, Liang Liu, Yi Tu, Dong Zeng","doi":"10.1016/j.colsurfb.2026.115477","DOIUrl":"10.1016/j.colsurfb.2026.115477","url":null,"abstract":"<div><div>Biodegradable magnesium (Mg) and its alloys can degrade safely in vivo without toxicity to the human body. However, the major bottleneck inhibiting Mg-based implants’ clinical use is the high corrosion rate. The serious corrosion leads to loss of mechanical integrity prematurely and bad biocompatibility. To break the bottleneck, modification with anticorrosive and bioactive coating is an ideal strategy. Metal-organic frameworks (MOFs) show good anticorrosive performance and perform good biocompatibility with up-and-coming applications in biomedical area such as drug delivery system, biological imaging and antibacterial property. Although numerous reports have reviewed the preparation and application of magnesium-based implant coating, relatively few report the MOF membranes coating of magnesium-based implant. Herein, this review provides the strategies for controlling corrosion of magnesium-based implants. Meanwhile, fabrication of nanoscale MOF membranes (in-situ growth and secondary growth method) is also mentioned. The application of MOFs based materials in the fields of corrosion protection and biomedicine are introduced. This work aims to provide a theoretical basis for addressing the key challenges of corrosion protection and biofunctionalization of degradable metal implants by systematically analyzing the functional characteristics and engineering design principles of MOFs coatings on magnesium-based implants.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"262 ","pages":"Article 115477"},"PeriodicalIF":5.6,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146076898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biosynthetic fingerprints and strain-specific characterization of bacterial cellulose from vinegar-derived Komagataeibacter spp. 醋源Komagataeibacter spp细菌纤维素的生物合成指纹图谱及菌株特异性表征。

IF 5.6 2区医学

Colloids and Surfaces B: Biointerfaces Pub Date : 2026-06-01 Epub Date: 2026-01-22 DOI: 10.1016/j.colsurfb.2026.115453

Elif Naz Gürsoy, M. Burcu Kulahci, Kubra Sener, K. Barbaros Balabanli, Sule Coskun Cevher

{"title":"Biosynthetic fingerprints and strain-specific characterization of bacterial cellulose from vinegar-derived Komagataeibacter spp.","authors":"Elif Naz Gürsoy, M. Burcu Kulahci, Kubra Sener, K. Barbaros Balabanli, Sule Coskun Cevher","doi":"10.1016/j.colsurfb.2026.115453","DOIUrl":"10.1016/j.colsurfb.2026.115453","url":null,"abstract":"<div><div>Bacterial cellulose (BC) is a nanostructured biopolymer renowned for its high crystallinity, exceptional water-holding capacity, and biocompatibility. While interspecies differences in BC properties are documented, comprehensive insights into strain-level biosynthetic variability within and across Komagataeibacter species remain limited. In this study, ten BC-producing strains were isolated from vinegar samples of diverse botanical origins and identified via 16S rRNA sequencing as belonging to three species: K. europaeus, K. medellinensis, and K. xylinus. Despite the limited taxonomic diversity, the isolates exhibited ten distinct “biosynthetic fingerprints,” as evidenced by pronounced variations in production yield, micro- and nanostructural morphology (FE-SEM), chemical functionality (FTIR), crystallinity (XRD), thermal stability (TGA), and water-holding capacity (WHC). Quantitatively, BC yields ranged from 2.10 to 3.01 g L⁻¹ , crystallinity indices from 34.5 % to 65.6 %, DTG_max from 337.4 °C to 372.1 °C, and WHC from 87.3 % to 95.7 %. Interestingly, some low-crystallinity samples demonstrated higher thermal stability, indicating that microstructural organization and fibril network compactness contribute significantly to thermal resistance beyond crystallinity alone. These findings establish that vinegar-derived Komagataeibacter strains harbor substantial strain-specific structural and functional heterogeneity, underscoring the necessity of strain-level selection and characterization when tailoring BC for advanced biomedical and industrial applications.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"262 ","pages":"Article 115453"},"PeriodicalIF":5.6,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146076988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Polydopamine-sealed mesoporous silica nanocarriers loaded with organic UV filters for effective full-spectrum UV protection 聚多巴胺密封介孔二氧化硅纳米载体负载有机紫外线过滤器，有效的全光谱紫外线防护

IF 5.6 2区医学

Colloids and Surfaces B: Biointerfaces Pub Date : 2026-06-01 Epub Date: 2026-01-27 DOI: 10.1016/j.colsurfb.2026.115481

Zixin Kang , Kehan Du , Zhuo-Ran Yang , Shunlan Luo , Xiaoping Zeng , Dawei Wang , Hongyang Zhao , Xiaowen Ou , Qianqian Liu , Hao Jiang , Jiangyu Wu

{"title":"Polydopamine-sealed mesoporous silica nanocarriers loaded with organic UV filters for effective full-spectrum UV protection","authors":"Zixin Kang , Kehan Du , Zhuo-Ran Yang , Shunlan Luo , Xiaoping Zeng , Dawei Wang , Hongyang Zhao , Xiaowen Ou , Qianqian Liu , Hao Jiang , Jiangyu Wu","doi":"10.1016/j.colsurfb.2026.115481","DOIUrl":"10.1016/j.colsurfb.2026.115481","url":null,"abstract":"<div><div>Ultraviolet radiation induces skin carcinogenesis through DNA damage and oxidative stress, driving demand for high-efficacy sunscreens. Current organic filters (e.g., octyl methoxycinnamate, OMC) suffer from narrow spectral coverage and phototoxicity. To address these limitations, we engineered OMC-loaded hollow mesoporous silica nanoparticles with polydopamine coating (OMC@HMSN@PDA). This nanoplatform achieved: (i) synergistic broad-spectrum protection, the sun protection factor (SPF) and UVA protection factor (UVAPF) up to 54 ± 0.74, 26.8 ± 6 with the concentration of 6 wt% OMC respectively, exceeding OMC@HMSN by 10.4-fold in UVB and 11.2-fold in UVA attenuation; (ii) 93.1 ± 1.2 % of DPPH and 98.5 ± 2.5 % of ABTS radical scavenging at 10 µg mL<sup>−1</sup>, and 94.6 ± 0.03 % intracellular reactive oxygen species (ROS) suppression; and (iii) prevention of the payload leakage and photo-instability of OMC, resolution of OMC’s phototoxicity with above 80 % cell viability <em>in vitro</em>. <em>In vivo</em> studies demonstrated prevention of UV-induced epidermal hyperplasia and lower inflammation. This technology establishes a promising approach for photoprotection integrating UV filtering, antioxidant activity, and enhanced safety.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"262 ","pages":"Article 115481"},"PeriodicalIF":5.6,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146048911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanomaterial-based antibacterial strategies: Mechanisms, rational design, and future perspectives 基于纳米材料的抗菌策略：机制、合理设计和未来展望

IF 5.6 2区医学

Colloids and Surfaces B: Biointerfaces Pub Date : 2026-06-01 Epub Date: 2026-01-27 DOI: 10.1016/j.colsurfb.2026.115478

Yong Su , Nini Wang , Jiaqi Li, Ying Han, Haiming Fan, Yuan He

{"title":"Nanomaterial-based antibacterial strategies: Mechanisms, rational design, and future perspectives","authors":"Yong Su , Nini Wang , Jiaqi Li, Ying Han, Haiming Fan, Yuan He","doi":"10.1016/j.colsurfb.2026.115478","DOIUrl":"10.1016/j.colsurfb.2026.115478","url":null,"abstract":"<div><div>The increasing challenge of antimicrobial resistance necessitates the development of innovative treatment strategies. This review comprehensively examines the recent advancements in nanomaterial-based antibacterial platforms, focusing on their diverse mechanisms of action, including chemodynamic therapy, nanozyme therapy, photodynamic therapy, sonodynamic therapy, photothermal therapy, magnetothermal therapy, ion interference therapy, and gas therapy. Furthermore, the integration of multimodal therapies as well as strategies to integrate diagnostic-therapeutic functionalities is highlighted as a promising avenue for enhanced antibacterial treatment. Next, the rational design approaches employed to enhance the performance of nanomaterials, such as elemental doping, morphology control, and surface functionalization, are discussed. Despite significant progress, critical challenges remain in the areas of targeting precision, therapeutic efficiency under complex physiological conditions, biosafety, and clinical translation. This work provides valuable insights and forward-looking perspectives to guide the development of next-generation nano-antibacterial agents with enhanced functionality.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"262 ","pages":"Article 115478"},"PeriodicalIF":5.6,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146048910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0