Colloids and Surfaces B: Biointerfaces最新文献

{"title":"Application of heterologous extracellular vesicles and their analogs in anti-tumor activity research","authors":"Jianguo Gao,&nbsp;Yanqing Wu,&nbsp;Yuwei Zhao,&nbsp;Yingzhi Lu,&nbsp;Xiaoqing Cai","doi":"10.1016/j.colsurfb.2025.114850","DOIUrl":"10.1016/j.colsurfb.2025.114850","url":null,"abstract":"<div><div>Extracellular vesicles and their analogues can mediate intercellular communication for gene regulation, thereby activating corresponding cellular functions, which demonstrates promising applications in disease diagnosis and treatment. Extensive studies have indicated that extracellular vesicles and their analogues exhibit remarkable efficacy in various pharmacological activities, including anti-tumor effects, immune modulation, prevention and treatment of cardiovascular diseases, as well as tissue regeneration. Heterologous extracellular vesicles and their analogues possess diverse biological activities attributed to their compositions, distributions, and mechanisms of action. Their specific targeting ability, high biocompatibility, and low immunogenicity render them ideal delivery vehicles for precision therapeutic interventions. This article aims to comprehensively review the mechanisms of action of extracellular vesicles and their analogues in anti-tumor activity, as well as their unique advantages as drug delivery carriers, with the goal of providing a necessary reference foundation for further application and development in anti-tumor therapy.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"254 ","pages":"Article 114850"},"PeriodicalIF":5.4,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144240340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent progress in hyaluronic acid based nanoparticles for the anti-tumor application","authors":"Xiaoning Wang ,&nbsp;Xihua Li ,&nbsp;Kun Liu ,&nbsp;Yang Bai","doi":"10.1016/j.colsurfb.2025.114860","DOIUrl":"10.1016/j.colsurfb.2025.114860","url":null,"abstract":"<div><div>Traditional nano-carriers used for anti-tumor applications primarily rely on the enhanced permeability and retention (EPR) effect to achieve effective drug release and cancer therapy. However, the passive targeting mechanism of these nano-carriers often results in inadequate accumulation and unsatisfied therapeutic efficacy in tumor tissues. Therefore, the development of active targeting nano-carriers for improved therapeutic outcomes has emerged as the major focus in the anti-tumor field. Notably, hyaluronic acid (HA), as a type of natural functional biomacromolecule, has gained significant attention for its remarkable water-solubility, biocompatibility, biodegradability, and CD44-receptor mediated active targeting properties. Consequently, HA has been developed as one potential candidate for the construction of nanoparticles for drug delivery, particularly in the active targeting cancer therapy field. This paper provides a comprehensive summary of the modification of HA, HA-based nano-carriers and their applications, including chemotherapy, photothermal therapy, photodynamic therapy, chemodynamic therapy, and combined therapy. The different therapeutic mechanisms and recent advancements in HA-based nano-carriers are discussed. Additionally, based on the progress of HA-based nanoparticles, the research trends in this area are also anticipated. Overall, this paper exhibits the potential of HA-based nano-carriers in active targeting cancer therapy and provides insights into their applications and future directions in the field.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"254 ","pages":"Article 114860"},"PeriodicalIF":5.4,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144240337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"NIR-triggered in situ self-supplied H2O2 for boosting photothermal disinfection via CuO2-mediated catalytic cascade reaction","authors":"Mengyu Ding ,&nbsp;Bokai Zhou ,&nbsp;Junjie Piao ,&nbsp;Aijun Cai ,&nbsp;Mingshi Jin","doi":"10.1016/j.colsurfb.2025.114863","DOIUrl":"10.1016/j.colsurfb.2025.114863","url":null,"abstract":"<div><div>Herein, we constructed a near-infrared (NIR) responsive CuS/CuO₂ cascade nanozyme system addressing the critical limitation of exogenous H₂O₂ dependency in conventional therapies. This system incorporates NIR-responsive antibacterial CuS/CuO₂ composite based on cascade nanoenzymes. The loaded CuO₂ nanoparticles (NPs) spontaneously generate Cu²⁺ and H₂O₂ in situ upon NIR irradiation (808 nm). This initiates a dual catalytic pathway: (1) Cu²⁺-mediated Fenton-like reactions and (2) H₂O₂-activated peroxidase-like activity, synergistically producing ·OH radicals (EPR-confirmed). Under NIR irradiation, CuO₂ releases H₂O₂ that activates the peroxidase-like activity of CuS. During the following cascade reaction, Cu²⁺ catalyzes a Fenton-like reaction to produce a large amount of ·OH, while H₂O₂ activates peroxidase-like activity in the CuS/CuO₂ composite. Additionally, CuS/CuO₂ also exhibits oxidase-like activity. The oxidase-like activity coupled with the cascade reaction simulated with photothermal conditions allows CuS/CuO₂ (100 μg/mL) to effectively destroy <em>Escherichia coli</em> (<em>E. coli</em>), <em>Staphylococcus aureus</em> (<em>S. aureus</em>), and Methicillin-resistant <em>Staphylococcus aureus</em> (MRSA). Moreover, the CuS/CuO₂ composite effectively inhibits the formation of biofilms of <em>E. coli</em>, <em>S. aureus</em>, and MRSA. ·OH was confirmed to be the main free radical during the antimicrobial process of CuS/CuO₂. <em>In vivo</em> anti-infection assays prove that CuS/CuO₂ could accelerate wound healing under NIR irradiation with negligible toxicity. This self-sustaining system eliminates exogenous H₂O₂ requirements while achieving combinatorial antimicrobial efficacy through photothermal-potentiated nanozyme cascades.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"254 ","pages":"Article 114863"},"PeriodicalIF":5.4,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144240341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of sialic acid and macromolecular depletion interactions in red blood cell adhesion: Insights from interference reflection microscopy","authors":"Zhengwen Zhang ,&nbsp;Huimin Teo ,&nbsp;Timo Preißing ,&nbsp;Björn Neu","doi":"10.1016/j.colsurfb.2025.114861","DOIUrl":"10.1016/j.colsurfb.2025.114861","url":null,"abstract":"<div><div>Red blood cell (RBC) adhesion plays a pivotal role in vascular physiology and has been implicated in various pathological conditions, including diabetes and hypertension. This study aims to elucidate the interplay between sialic acid removal and macromolecular depletion interactions on RBC adhesion using interference reflection microscopy (IRM). The adhesion of RBC to surfaces coated with albumin in the presence of polymers is quantitatively assessed, focusing on how neuraminidase-induced desialylation influences adhesion dynamics. Our findings demonstrate that sialic acid removal significantly enhances RBC adhesion in solutions containing high-molecular-weight dextran, while at the same time, membrane undulations were reduced. No significant increase in the adhesion energies was observed without the presence of polymers. However, in the presence of the depleted polymer, the adhesion energy correlates positively with neuraminidase concentration. This indicates a substantial increase in depletion interaction energy due to the altered cell surface properties and suggests that macromolecular depletion forces might contribute to abnormal RBC adhesion in pathologies associated with reduced surface charge, providing new insights into the biophysical mechanisms of RBC adhesion in health and disease.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"254 ","pages":"Article 114861"},"PeriodicalIF":5.4,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144240338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enamel remineralization enhancement by mesoporous bioactive glass (MBG) in commercial fluoride varnish and development of an MBG/fluoride chitosan composite hydrogel","authors":"Linjing Yang ,&nbsp;Jiayu Guo ,&nbsp;Dan Lin","doi":"10.1016/j.colsurfb.2025.114853","DOIUrl":"10.1016/j.colsurfb.2025.114853","url":null,"abstract":"<div><div>With its excellent bioactivity and mesoporosity that endows controlled release of chemical or biological cues, mesoporous bioactive glass (MBG) is widely used in bone regeneration, yet less recognized in dentistry. This study investigates the enamel remineralization effect of MBG in commercial fluoride varnishes (FVs), and developes an MBG/fluoride chitosan composite hydrogel. MBG powders are added into commercial FVs (3M™ Clinpro™, Duraphat™) at different ratios to screen out the optimized proportion for mineralization. Further, an MBG/fluoride chitosan composite hydrogel (MBG/NaF/CS) has been developed at the optimized ratio, and its <em>in vitro</em> remineralization effect on tooth enamel after artificial saliva soaking for 1/3/5 days are evaluated via SEM, EDS and Vickers hardness test. Incorporation of 5 wt% MBG in FVs results in the most rapid and extensive hydroxyapatite (HAp) deposition within 24 h. MBG/NaF/CS hydrogel exhibits homogeneity instead of fluoride precipitation in NaF/CS hydrogel. The addition of MBG contributes to rapid, larger, and continuous fluorapatite (FAp) remineralization on enamel surface over time, and restores the hardness of enamel over normal level after 24 h. It is indicated that F^- adsorption in MBG mesopores endowed the MBG/NaF/CS hydrogel an unreported continuous enamel remineralization effect up to 5 days under daily brushing. MBG enhances enamel remineralizing capacity of commercial FVs, and the novel MBG/fluoride chitosan composite hydrogel with continuous enamel remineralization effect represented a promising approach for caries management. This study may shed light on further application of MBG in dentistry.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"254 ","pages":"Article 114853"},"PeriodicalIF":5.4,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144240308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dual-responsive zwitterionic nanogels with synergistic charge reversal and hypoxia-activated drug release for precise tumor targeting and enhanced chemotherapy","authors":"Yuan Liao ,&nbsp;Zhihao Wang ,&nbsp;Mengyao Guo ,&nbsp;Yingying Yang ,&nbsp;Xinyang Chu ,&nbsp;Leitao Zhang ,&nbsp;Wenlan Wu ,&nbsp;Junbo Li ,&nbsp;Qiuli Cheng","doi":"10.1016/j.colsurfb.2025.114839","DOIUrl":"10.1016/j.colsurfb.2025.114839","url":null,"abstract":"<div><div>Developing nanomedicine delivery systems that respond to endogenous stimuli from the tumor microenvironment for the precise tumor targeting and controlled release of chemotherapeutic drugs has become a promising candidate to enhance cancer therapy. Here, we designed a zwitterionic nanogel system (named PMm) with charge-switchable and hypoxia-responsive properties for tumor targeting and on-demand drug release. PMm was synthesized through precipitation polymerization, strategically integrating a sulfamide-quaternary ammonium zwitterionic monomer (MPTA) and an azobenzene (azo) based crosslinker (MEFA). In the weakly acidic tumor microenvironment, PMm@DOX nanogels underwent a rapid surface charge reversal (to positive) via protonation of imine moieties, promoting deep tumor penetration and cellular uptake. Following cellular internalization, hypoxia-activated cleavage of the MEFA crosslinker induced the nanogel disassembly and DOX release, leading to the apoptosis of tumor cells. <em>In vitro</em> and <em>in vivo</em> studies demonstrated this dual-responsive nanogel platform synergistically integrated charge-driven targeting and hypoxia-triggered drug release, overcoming the limitations of conventional nanocarriers, enhancing tumor accumulation and showing superior antitumor efficacy. By intelligent surface engineering and microenvironmental responsiveness, the PMm@DOX system represents a promising strategy to amplify chemotherapeutic efficacy while minimizing off-target toxicity.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"254 ","pages":"Article 114839"},"PeriodicalIF":5.4,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144240334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Injectable glycol chitosan thermogel loaded with placental mesenchymal stem cells secretome for enhanced wound healing and tissue regeneration","authors":"Ryoung Eun Kim ,&nbsp;Eun Young Koo ,&nbsp;Eun Young Kim ,&nbsp;Se Yeon Shin ,&nbsp;Seong A Park ,&nbsp;Kang Moo Huh ,&nbsp;Min Kyu Kim","doi":"10.1016/j.colsurfb.2025.114851","DOIUrl":"10.1016/j.colsurfb.2025.114851","url":null,"abstract":"<div><div>Wound healing is a complex biological process that is essential for restoring tissue integrity and function. This study presents an innovative injectable thermosensitive hydrogel (thermogel) formulation based on hexanoyl glycol chitosan (HGC) loaded with placental mesenchymal stem cell (MSC) secretome to enhance wound healing and tissue regeneration. The GC-based thermogel is designed to promote the delivery of bioactive factors from the MSC secretome, including cytokines and growth factors, which are critical for the healing process. The thermogel exhibits favorable physicochemical properties, including a sol-gel transition at physiological temperatures and excellent structural integrity post-injection. In vitro studies demonstrated that the secretome-loaded HGC thermogel significantly enhanced cell proliferation, migration, and angiogenesis. In vivo experiments further confirmed that the thermogel accelerated wound closure and re-epithelialization in a murine wound model. These findings suggest that the multifunctional properties of this HGC-based thermogel, combined with the bioactivity of MSC secretome, offer a promising therapeutic approach for enhancing wound healing and promoting tissue regeneration.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"254 ","pages":"Article 114851"},"PeriodicalIF":5.4,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144240342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterization of the surface charge and reactivity of Schizophyllum commune mycelium material","authors":"Antonio d'Errico ,&nbsp;Michaela Schröpfer ,&nbsp;Anke Mondschein ,&nbsp;Han A.B. Wösten","doi":"10.1016/j.colsurfb.2025.114852","DOIUrl":"10.1016/j.colsurfb.2025.114852","url":null,"abstract":"<div><div>Mycelium fabrics are an emerging alternative to textiles and leather. Here we studied surface charge and reactivity of water-washed and KOH-treated mycelium and water-extracted and KOH-extracted cell walls from <em>Schizophyllum commune</em>. Zeta potential analysis was used to study the surface charge of the mycelium, while FTIR, amino acid analysis and isoelectric point shift were used to assess functional group accessibility and reactivity of the cross-linker glutaraldehyde. The isoelectric point (pI) of water-washed and KOH-treated mycelium was found at pH 2.75 and pH 3.58, respectively, and at pH 3.55 for KOH-extracted cell walls. No pI was found for water-extracted cell walls in a pH range of 2–9. Treatment of water-washed mycelium and water-extracted cell walls with glutaraldehyde resulted in a pI shift from pH 2.75 to pH 3.07 and from no pI in the range of 2–9 to a pI of 2.72, suggesting binding to acid groups. By contrast, a pI shift to lower pH (from pH 3.58 and 3.55 to pH 2.77 and 3.17, respectively) was observed after treatment of KOH-washed mycelium and KOH-extracted cell walls with glutaraldehyde, indicating binding to basic groups. Indeed, amino acid analysis showed a reduction in lysine after treatment with the cross-linker. Together, results indicate that a higher incidence of cross-linking of glutaraldehyde to polysaccharides is responsible for the pI shift to higher pH in the case of the water-treated mycelium, while a higher incidence of binding to basic amino acids causes the shift to lower pH in the case of KOH-treated mycelium and KOH-extracted cell walls.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"254 ","pages":"Article 114852"},"PeriodicalIF":5.4,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144240335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in the design and application of glycolysis-related nanodelivery systems for anti-tumor","authors":"Yanghui Zhou ,&nbsp;Meijing Liu ,&nbsp;Na Lu ,&nbsp;Xiangping Deng ,&nbsp;Xin Chen ,&nbsp;Lijing Tang ,&nbsp;Zhizhong Xie ,&nbsp;Xiaoyong Lei ,&nbsp;Xiaoyan Yang ,&nbsp;Saidong Zhou ,&nbsp;Guotao Tang ,&nbsp;Zhe Wang","doi":"10.1016/j.colsurfb.2025.114844","DOIUrl":"10.1016/j.colsurfb.2025.114844","url":null,"abstract":"<div><div>Hypoxia is a common feature of solid tumors, and activation of hypoxia-inducing factors in the tumor hypoxia microenvironment can lead to complex reprogramming of glucose metabolism in tumor cells. In particular, the unique glucose metabolism pattern of tumor cells, mainly glycolysis pathway, provides conditions for tumor growth, metastasis, immune escape and drug resistance. Drug development for glycolysis-related targets is more targeted and safer than traditional chemotherapy drugs, and drug delivery systems offer favorable strategies for improving the targeted therapy of these drugs in vivo. Here, we review drug delivery systems that target tumor glycolysis, including specific small molecule inhibitors, siRNA, and other nanodelivery systems that affect glycolysis, and note the multifunctional anti-tumor nanodelivery systems that combine multiple therapeutic modalities including chemotherapy, photothermal, photodynamic, sonodynamic, chemodynamic therapies, as well as photoacoustic, magnetic resonance imaging. Several major challenges and future directions in the development and transformation of anti-tumor nanostrategies for glycolysis are discussed. The development of innovative anti-tumor nanodelivery systems related to tumor glycolysis could provide powerful weapons against tumor progression in the foreseeable future.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"254 ","pages":"Article 114844"},"PeriodicalIF":5.4,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144221328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"Multifunctional composite soluble microneedle patch based on \"one stone, three birds\" strategy for promoting the healing of infectious wounds\" [Colloids Surf. B: Biointerfaces 241 (2024) 114049].","authors":"Weili Yang, Min Cao, Wenxin Wang, Ningning Diao, Xiaowei Liu, Yue Hu, Xinxin Wang, Tianying Sun, Chunjing Guo, Daquan Chen","doi":"10.1016/j.colsurfb.2025.114837","DOIUrl":"https://doi.org/10.1016/j.colsurfb.2025.114837","url":null,"abstract":"","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":" ","pages":"114837"},"PeriodicalIF":5.4,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144223885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}