{"title":"Methane Production Is More Sensitive to Temperature Increase than Aerobic and Anaerobic Methane Oxidation in Chinese Paddy Soils","authors":"Wang-ting Yang, Evgenios Agathokleous, Jiang-hua Wu, Hong-yang Chen, Rong-jun Wu, He-chen Huang, Bing-jie Ren, Si-le Wen, Li-dong Shen, Wei-qi Wang","doi":"10.1021/acs.est.4c04494","DOIUrl":"https://doi.org/10.1021/acs.est.4c04494","url":null,"abstract":"Methane emissions from paddy fields can increase under future warming scenarios. Nevertheless, a comprehensive comparison of the temperature sensitivity of methane-related microbial processes remains elusive. Here, we revealed that the temperature sensitivity of methane production (activation energy (<i>E</i><sub>a</sub>) = 0.94 eV; 95% confidence interval (CI), 0.78–1.10 eV) and aerobic (<i>E</i><sub>a</sub> = 0.49 eV; 95% CI, 0.34–0.65 eV) and anaerobic (<i>E</i><sub>a</sub> = 0.46 eV; 95% CI, 0.30–0.62 eV) methane oxidation exhibited notable spatial heterogeneity across 12 Chinese paddy fields spanning 35° longitude and 18° latitude. In addition, the <i>E</i><sub>a</sub> values of aerobic and anaerobic methane oxidation were significantly positively and negatively correlated to the latitude, respectively, while there was no significant correlation between the <i>E</i><sub>a</sub> of methane production and the latitude. Overall, there were no soil factors that had a significant effect on the <i>E</i><sub>a</sub> of methane production. The <i>E</i><sub>a</sub> of aerobic methane oxidation was primarily influenced by the contents of ammonium and clay, whereas the <i>E</i><sub>a</sub> of anaerobic methane oxidation was mainly influenced by the conductivity. Despite the variation, the overall temperature sensitivity of methane production was significantly higher than that of oxidation at a continental scale; therefore, an increase in the emission of methane from paddy fields will be predicted under future warming. Taken together, our study revealed the characteristics of temperature sensitivity of methane production and aerobic and anaerobic methane oxidation simultaneously in Chinese paddy fields, highlighting the potential roles of soil factors in influencing temperature sensitivity.","PeriodicalId":36,"journal":{"name":"环境科学与技术","volume":null,"pages":null},"PeriodicalIF":9.028,"publicationDate":"2024-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142430432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Development of a Physiologically Based Pharmacokinetic (PBPK) Model for F-53B in Pregnant Mice and Its Extrapolation to Humans","authors":"Jing Zhang, Shen-Pan Li, Qing-Qing Li, Yun-Ting Zhang, Guang-Hui Dong, Alexa Canchola, Xiaowen Zeng, Wei-Chun Chou","doi":"10.1021/acs.est.4c05405","DOIUrl":"https://doi.org/10.1021/acs.est.4c05405","url":null,"abstract":"Chlorinated polyfluorinated ether sulfonic acid (F-53B), a commonly utilized alternative for perfluorooctane sulfonate, was detected in pregnant women and cord blood recently. However, the lack of detailed toxicokinetic information poses a significant challenge in assessing the human risk assessment for F-53B exposure. Our study aimed to develop a physiologically based pharmacokinetic (PBPK) model for pregnant mice, based on toxicokinetic experiments, and extrapolating it to humans. Pregnant mice were administered 80 μg/kg F-53B orally and intravenously on gestational day 13. F-53B concentrations in biological samples were analyzed via ultraperformance liquid chromatography–mass spectrometry. Results showed the highest F-53B accumulation in the brain, followed by the placenta, amniotic fluid, and liver in fetal mice. These toxicokinetic data were applied to F-53B PBPK model development and evaluation, and Monte Carlo simulations were used to characterize the variability and uncertainty in the human population. Most of the predictive values were within a 2-fold range of experimental data (>72%) and had a coefficient of determination (R<sup>2</sup>) greater than 0.68. The developed mouse model was then extrapolated to the human and evaluated with human biomonitoring data. Our study provides an important step toward improving the understanding of toxicokinetics of F-53B and enhancing the quantitative risk assessments in sensitive populations, particularly in pregnant women and fetuses.","PeriodicalId":36,"journal":{"name":"环境科学与技术","volume":null,"pages":null},"PeriodicalIF":9.028,"publicationDate":"2024-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142415680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
环境科学与技术Pub Date : 2024-10-12DOI: 10.1021/acs.est.4c06691
Eva Ternon, Julie Dinasquet, Lucia Cancelada, Benjamin Rico, Alexia Moore, Emily Trytten, Kimberly A. Prather, William H. Gerwick, Rodolphe Lemée
{"title":"Sea-Air Transfer of Ostreopsis Phycotoxins Is Driven by the Chemical Diversity of the Particulate Fraction in the Surface Microlayer","authors":"Eva Ternon, Julie Dinasquet, Lucia Cancelada, Benjamin Rico, Alexia Moore, Emily Trytten, Kimberly A. Prather, William H. Gerwick, Rodolphe Lemée","doi":"10.1021/acs.est.4c06691","DOIUrl":"https://doi.org/10.1021/acs.est.4c06691","url":null,"abstract":"Blooms of <i>Ostreopsis</i> cf. <i>ovata</i> pose an emerging health threat, causing respiratory disorders in various coastal regions. This dinoflagellate produce potent phycotoxins named ovatoxins that can be transferred from the seawater to the atmosphere. However, the biotic and abiotic conditions affecting their transfer are still unknown. In this study, we investigate the sea-to-air transfer of <i>O.</i> cf <i>ovata</i> phycotoxins using a process study in an aerosol reference tank (MART) and field observations. The process study exhibited a positive correlation between the phycotoxin content in sea spray aerosol (up to 832.59 ng m<sup>–3</sup>) and the particulate phycotoxin fraction in the water column and surface microlayer. In contrast, in the natural system, aerosolized phycotoxins were only observed in one out of six air collection (total toxins 0.59 ng m<sup>–3</sup>) despite optimal wind conditions. In both the process study and the natural system, ovatoxins represented only a minor fraction of the total toxin content, which was comprised of up to 90% liguriatoxins. In seawater, while no solubilized ovatoxins were detected, the concentration in dissolved liguriatoxin-a reached up to 19.07 μg L<sup>–1</sup>. These results underscore the need for future research on the liguriatoxins, and on their toxicity to establish safe exposure thresholds for beachgoers.","PeriodicalId":36,"journal":{"name":"环境科学与技术","volume":null,"pages":null},"PeriodicalIF":9.028,"publicationDate":"2024-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142415854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
环境科学与技术Pub Date : 2024-10-12DOI: 10.1021/acs.est.4c10136
Yaqiang Wei, Jiao Zhang, Xinde Cao, Tian-Chyi Jim Yeh, Yuling Chen, Chao Chen, Minghui Xiang, Liheng Wang, Zi Zhan, Hui Li
{"title":"Fukushima’s Radioactive Water Threatens Coastal Groundwater","authors":"Yaqiang Wei, Jiao Zhang, Xinde Cao, Tian-Chyi Jim Yeh, Yuling Chen, Chao Chen, Minghui Xiang, Liheng Wang, Zi Zhan, Hui Li","doi":"10.1021/acs.est.4c10136","DOIUrl":"https://doi.org/10.1021/acs.est.4c10136","url":null,"abstract":"Figure 1. Fukushima radioactive water poses a threat to coastal groundwater under the impact of global seawater intrusion. (a) Global seawater intrusion results in a heightened degree of inland salinization. By the year 2100, the inland shift (kilometers) of the saline water wedge, in comparison to the year 2000, is forecasted on the basis of the RCP 8.5 scenario. RCP, which stands for a representative concentration pathway, is a framework employed to outline future global greenhouse gas emissions and concentrations. RCP 8.5 delineates a high-emission scenario. (34) (b) Pathways and protection measures for the threat of radioactive water on coastal groundwater, including ① seawater intrusion, ② subsea engineering, and ③ vertical infiltration that pose threats to coastal groundwater by allowing radioactive contaminants to seep through soil layers and reach underlying aquifers, jeopardizing both groundwater quality and human health. (11,22,33,46) The management strategy mainly revolves around managed aquifer recharge (MAR), which includes recharge wells and recharge dams, offering effective preventive measures to mitigate the harm of radioactive water. (47−49) Additionally, barrier walls can effectively weaken the interaction between saltwater and freshwater, preventing marine radioactive water from entering coastal groundwater. (51) Y.W. led the conceptualization, writing, and figure drafting. J.Z., Z.Z., and Y.C. assisted with writing and figures. X.C. and H.L. conceived the ideas and designed the framework. L.W., T.-C.J.Y., C.C., and M.X. helped to improve the writing of the paper. All authors approved publication. <b>Dr. Yaqiang Wei</b> is currently an Associate Professor at Shanghai University. He completed his postdoctoral research at Shanghai Jiao Tong University and obtained his Ph.D. degree from the University of Chinese Academy of Sciences in 2017, with a joint training program at the University of Arizona, United States. His primary research focus is on the migration, transformation, and fate of contaminants in soil and groundwater. He has led several research projects, including a project of key fund and a Youth Fund from the National Natural Science Foundation, and two subprojects under the National Key Research and Development Program for Soil Pollution Causes and Control Technologies. He also serves as a young editorial board member for journals such as <i>Eco-Environment & Health</i> and <i>Agriculture Communications</i>. <b>Hui Li</b> is a full professor at the School of Environmental and Chemical Engineering, Shanghai University. He is the recipient of the National Science Fund for Distinguished Young Scholars and serves as the Chief Scientist of the National Key Research and Development Program. He has led more than 20 national and provincial key scientific research projects. He has been engaged in multidisciplinary research on environmental behavior, ecotoxicology, remediation technologies of pollutants, and realization path","PeriodicalId":36,"journal":{"name":"环境科学与技术","volume":null,"pages":null},"PeriodicalIF":9.028,"publicationDate":"2024-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142415728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
环境科学与技术Pub Date : 2024-10-12DOI: 10.1021/acs.est.4c09209
Cuicui Feng, Song Ge, Jiangning Zeng, Liuyue He, Guanqiong Ye
{"title":"Mapping the Global Carbon Emissions of Marine Sectors","authors":"Cuicui Feng, Song Ge, Jiangning Zeng, Liuyue He, Guanqiong Ye","doi":"10.1021/acs.est.4c09209","DOIUrl":"https://doi.org/10.1021/acs.est.4c09209","url":null,"abstract":"The ocean serves as a vital ecosystem for sustaining life on earth and ensuring human well-being. Presently, there is a significant surge in global demand for various ocean-based economic activities, including fishing, shipping, offshore wind energy production, maritime tourism, and so on. However, this growth has also resulted in an increase in emissions from marine sectors, which have not been thoroughly evaluated or analyzed. It is therefore necessary to conduct comprehensive evaluations of the current emissions, covering marine sectors. To address this need, through this Perspective, we have globally analyzed and discussed carbon emissions linked to maritime transportation, marine capture fisheries, marine aquaculture, offshore wind, ocean renewables, and crude oil production. Additionally, we explored country-specific scales for these emissions and discussed points for future research to address the existing gaps. By gaining a better understanding of emissions over the oceans, policymakers could prioritize policy measures for achieving emission reduction goals and promote sustainable ocean development.","PeriodicalId":36,"journal":{"name":"环境科学与技术","volume":null,"pages":null},"PeriodicalIF":9.028,"publicationDate":"2024-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142415727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Placental Transcriptomic Signatures of Prenatal Phthalate Exposure and Identification of Placenta-Brain Genes Associated with the Effects of Phthalate Exposure on Neurodevelopment in Children","authors":"Jiawen Ren, Yifan Wang, Yimin Zhang, Heyue Jin, Jingjing Cheng, Fangbiao Tao, Yumin Zhu","doi":"10.1021/acs.est.4c04082","DOIUrl":"https://doi.org/10.1021/acs.est.4c04082","url":null,"abstract":"Prenatal exposure to phthalates may affect placental function and fetal development, but the underlying mechanisms are unclear. The aim of our study was to explore the alterations in the placental transcriptome associated with prenatal phthalate exposure and to further analyze whether the placental–brain axis (PBA) genes play a mediating role in the association between prenatal phthalate exposure and children’s neurodevelopment. We included 172 participants from the Ma’anshan Birth Cohort and collected data on seven phthalate metabolites in urine during pregnancy, placental tissue RNA-seq, and neurodevelopment of offspring. Bioinformatics analysis revealed that aberrant regulation of the placental transcriptome was associated with prenatal phthalate exposure. Exposure to phthalates during pregnancy was found to be associated with neurodevelopmental delay in children aged 6, 18, and 48 months using the multiple linear regression model. Meanwhile, employing mediation analysis, nine PBA genes were identified that mediate the association between exposure to phthalates during pregnancy and the neurodevelopment of children. Our study will provide a basis for potential mechanisms by which prenatal exposure to phthalates affects placental function and children’s neurodevelopment.","PeriodicalId":36,"journal":{"name":"环境科学与技术","volume":null,"pages":null},"PeriodicalIF":9.028,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142405665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
环境科学与技术Pub Date : 2024-10-11DOI: 10.1021/acs.est.4c05563
David G. Luglio, Michael J. Kleeman, Xin Yu, Jane C. Lin, Ting Chow, Mayra P. Martinez, Zhanghua Chen, Jiu-Chiuan Chen, Sandrah Proctor Eckel, Joel Schwartz, Frederick Lurmann, Rob McConnell, Anny H. Xiang, Md Mostafijur Rahman
{"title":"Prenatal Exposure to Source-Specific Fine Particulate Matter and Autism Spectrum Disorder","authors":"David G. Luglio, Michael J. Kleeman, Xin Yu, Jane C. Lin, Ting Chow, Mayra P. Martinez, Zhanghua Chen, Jiu-Chiuan Chen, Sandrah Proctor Eckel, Joel Schwartz, Frederick Lurmann, Rob McConnell, Anny H. Xiang, Md Mostafijur Rahman","doi":"10.1021/acs.est.4c05563","DOIUrl":"https://doi.org/10.1021/acs.est.4c05563","url":null,"abstract":"In this study, associations between prenatal exposure to fine particulate matter (PM2.5) from 9 sources and development of autism spectrum disorder (ASD) were assessed in a population-based retrospective pregnancy cohort in southern California. The cohort included 318,750 mother–child singleton pairs. ASD cases (<i>N</i> = 4559) were identified by ICD codes. Source-specific PM2.5 concentrations were estimated from a chemical transport model with a 4 × 4 km<sup>2</sup> resolution and assigned to maternal pregnancy residential addresses. Cox proportional hazard models were used to estimate the hazard ratios (HR) of ASD development for each individual source. We also adjusted for total PM2.5 mass and in a separate model for all other sources simultaneously. Increased ASD risk was observed with on-road gasoline (HR [CI]: 1.18 [1.13, 1.24]), off-road gasoline (1.15 [1.12, 1.19]), off-road diesel (1.08 [1.05, 1.10]), food cooking (1.05 [1.02, 1.08]), aircraft (1.04 [1.01, 1.06]), and natural gas combustion (1.09 [1.06, 1.11]), each scaled to standard deviation increases in concentration. On-road gasoline and off-road gasoline were robust for other pollutant groups. PM2.5 emitted from different sources may have different impacts on ASD. The results also identify PM source mixtures for toxicological investigations that may provide evidence for future public health policies.","PeriodicalId":36,"journal":{"name":"环境科学与技术","volume":null,"pages":null},"PeriodicalIF":9.028,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142405248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
环境科学与技术Pub Date : 2024-10-11DOI: 10.1021/acs.est.4c07735
Jing Guo, Yiwen Luo, Chao Fang, Jinsha Jin, Pu Xia, Bing Wu, Xiaowei Zhang, Hongxia Yu, Hongqiang Ren, Wei Shi
{"title":"Advancing the Effect-Directed Identification in Combined Pollution: Using Pathways to Link Effects and Toxicants","authors":"Jing Guo, Yiwen Luo, Chao Fang, Jinsha Jin, Pu Xia, Bing Wu, Xiaowei Zhang, Hongxia Yu, Hongqiang Ren, Wei Shi","doi":"10.1021/acs.est.4c07735","DOIUrl":"https://doi.org/10.1021/acs.est.4c07735","url":null,"abstract":"The difficulty in associating diverse pollutants with mixture effects has led to significant challenges in identifying toxicants in combined pollution. In this study, pathways were used to link effects and toxicants. By pathways evaluated by the concentration-dependent transcriptome, individual effects were extended to molecular mechanisms encompassing 135 pathways corresponding to 6 biological processes. Accordingly, mechanism-based identification of toxicants was achieved by constructing a pathway toxicant database containing 2413 chemical–pathway interactions and identifying pathway active fragments of 72 pathways. The developed method was applied to two different wastewaters, industrial wastewater OB and municipal wastewater HL. Although lethality and teratogenesis were both observed at the individual level, different molecular mechanisms were revealed by pathways, with cardiotoxicity- and genotoxicity-related pathways significantly enriched in OB, and neurotoxicity- and environmental information processing-related pathways significantly enriched in HL. Further suspect and nontargeted screening generated 59 and 86 causative toxicants in OB and HL, respectively, among which 29 toxicants were confirmed, that interacted with over 90% of enriched pathways and contributed over 50% of individual effects. After upgrading treatments based on causative toxicants, consistent removal of toxicants, pathway effects, and individual effects were observed. Mediation by pathways enables mechanism-based identification, supporting the assessment and management of combined pollution.","PeriodicalId":36,"journal":{"name":"环境科学与技术","volume":null,"pages":null},"PeriodicalIF":9.028,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142405525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
环境科学与技术Pub Date : 2024-10-11DOI: 10.1021/acs.est.4c06731
Yao Fu, Yuyan Ji, Yawen Tian, Fan Zhang, Nan Sheng, Jiayin Dai, Yitao Pan
{"title":"Unveiling Priority Emerging PFAS in Taihu Lake Using Integrated Nontarget Screening, Target Analysis, and Risk Characterization.","authors":"Yao Fu, Yuyan Ji, Yawen Tian, Fan Zhang, Nan Sheng, Jiayin Dai, Yitao Pan","doi":"10.1021/acs.est.4c06731","DOIUrl":"https://doi.org/10.1021/acs.est.4c06731","url":null,"abstract":"<p><p>Amidst tightening regulations, the proliferation of next-generation per- and polyfluoroalkyl substances (PFAS) necessitates a deeper understanding of their environmental fate and potential risks. Here, we conducted a comprehensive assessment of PFAS in the water and sediment of Taihu Lake, incorporating both nontarget and target screening, seasonal and geographical variation analysis, and risk prioritization. A total of 58 PFAS from 13 classes were identified, revealing complex PFAS contamination. In addition to short-chain perfluoroalkyl carboxylates (PFCAs) and sulfonates (PFSAs), bis(trifluoromethanesulfonyl)imide (Ntf2) and perfluoro-2,5-dimethyl-3,6-dioxo-heptanoic acid (C7 HFPO-TA) exhibited relatively high concentrations in water, with median values of 21.7 and 5.72 ng/L, respectively. Seasonal and geographical variation analysis revealed elevated levels of C7 HFPO-TA, Ntf2, and perfluorohexanoic acid (PFHxA) in the northeastern areas, suggesting transport via water diversion project. Multicriteria risk prioritization identified four high priority PFAS (Ntf2, C7 HFPO-TA, PFHxA, and perfluorooctanoic acid (PFOA)) in water and two high priority PFAS (hexafluoropropylene oxide dimer acid (HFPO-DA) and PFHxA) in sediment. Overall, this study revealed Ntf2 and C7 HFPO-TA as priority PFAS in Taihu Lake, underscoring the urgent necessity of evaluating risks associated with these emerging PFAS.</p>","PeriodicalId":36,"journal":{"name":"环境科学与技术","volume":null,"pages":null},"PeriodicalIF":10.8,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142398697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
环境科学与技术Pub Date : 2024-10-11DOI: 10.1021/acs.est.4c04246
Hannah Mahoney, Phillip Ankley, Catherine Roberts, Alicia Lamb, Matthew Schultz, Yutong Zhou, John P Giesy, Markus Brinkmann
{"title":"Unveiling the Molecular Effects of Replacement and Legacy PFASs: Transcriptomic Analysis of Zebrafish Embryos Reveals Surprising Similarities and Potencies.","authors":"Hannah Mahoney, Phillip Ankley, Catherine Roberts, Alicia Lamb, Matthew Schultz, Yutong Zhou, John P Giesy, Markus Brinkmann","doi":"10.1021/acs.est.4c04246","DOIUrl":"https://doi.org/10.1021/acs.est.4c04246","url":null,"abstract":"<p><p>The prevalence of per- and poly fluoroalkyl substances (PFASs) in the environment has prompted restrictions on legacy PFASs due to their recognized toxic effects. Consequently, alternative \"replacement\" PFASs have been introduced and are prevalent in environmental matrices. Few studies have investigated the molecular effects of both legacy and replacement PFASs under short-term exposures. This study aimed to address this by utilizing transcriptomic sequencing to compare the molecular impacts of exposure to concentrations 0.001-5 mg/L of the legacy PFOS and two of its replacements, PFECHS and FBSA. Using zebrafish embryos, the research assessed apical effects (mortality, morphology, and growth), identified differentially expressed genes (DEGs) and enriched pathways, and determined transcriptomic points of departure (tPoDs) for each compound. Results indicated that PFOS exhibited the highest relative potency, followed by PFECHS and then FBSA. While similarities were observed among the ranked DEGs across all compounds, over-representation analysis revealed slight differences. Notably, PFOS demonstrated the lowest tPoD identified to date. These findings raise concerns regarding the safety of emerging replacement PFASs and challenge assumptions about PFAS toxicity solely resulting from their accumulative potential. As replacement PFASs proliferate in the environment, this study underscores the need for heightened scrutiny of their effects and questions current regulatory thresholds.</p>","PeriodicalId":36,"journal":{"name":"环境科学与技术","volume":null,"pages":null},"PeriodicalIF":10.8,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142398698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}