环境科学与技术最新文献

Similar Oxygen Sensitivities of Different Steps of Denitrification in Estuarine Waters

IF 9.028 1区环境科学与生态学

环境科学与技术 Pub Date : 2025-04-04 DOI: 10.1021/acs.est.5c02248

Weiyi Tang, Samantha G. Fortin, Naomi Intrator, Jenna A. Lee, Moriah A. Kunes, Amal Jayakumar, Shannon J. Haynes, Sergey Oleynik, Daniel M. Sigman, Bess B. Ward

{"title":"Similar Oxygen Sensitivities of Different Steps of Denitrification in Estuarine Waters","authors":"Weiyi Tang, Samantha G. Fortin, Naomi Intrator, Jenna A. Lee, Moriah A. Kunes, Amal Jayakumar, Shannon J. Haynes, Sergey Oleynik, Daniel M. Sigman, Bess B. Ward","doi":"10.1021/acs.est.5c02248","DOIUrl":"https://doi.org/10.1021/acs.est.5c02248","url":null,"abstract":"Hypoxia is observed and projected to expand in many aquatic environments, largely due to excess anthropogenic nutrient inputs and climate change, thus influencing biogeochemical processes. Denitrification, generally an anaerobic process, removes bioavailable nitrogen and produces nitrous oxide (N2O). However, limited observations of the effect of oxygen on denitrification restrict our ability to estimate changes in the amount of bioavailable nitrogen and N2O emissions under anthropogenic perturbations and climate change. Here, we show that all denitrification steps increased, while the N2O production yield from denitrification decreased with decreasing oxygen in Chesapeake Bay – the largest estuary in the United States. The different steps of denitrification responded similarly to oxygen changes in Chesapeake Bay, unlike open ocean oxygen minimum zones, with implications for the accumulation or depletion of denitrification intermediates such as nitrite and N2O. Our observations also suggest that current model parametrizations of denitrification in Chesapeake Bay likely overestimate denitrification and nitrogen removal in the presence of oxygen, which would bias the evaluation of nutrient cycling, ecosystem productivity, and the extent of hypoxia. Overall, our newly derived oxygen sensitivities of denitrification could be used to improve model parametrizations of denitrification and constrain the nitrogen budget and N2O emissions in estuarine and coastal environments experiencing hypoxia.","PeriodicalId":36,"journal":{"name":"环境科学与技术","volume":"61 1","pages":""},"PeriodicalIF":9.028,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143776088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Contribution of Nilaparvata lugens Nicotinic Acetylcholine Receptor Subunits Toward Triflumezopyrim and Neonicotinoid Susceptibility

IF 9.028 1区环境科学与生态学

环境科学与技术 Pub Date : 2025-04-04 DOI: 10.1021/acs.est.5c02110

Yan-Chao Zhang, Zi-Xin Zhuang, Fan Zhang, Xiao-Yan Song, Wen-Nan Ye, Shun-Fan Wu, Chris Bass, Andrias O. O’Reilly, Congfen Gao

{"title":"Contribution of Nilaparvata lugens Nicotinic Acetylcholine Receptor Subunits Toward Triflumezopyrim and Neonicotinoid Susceptibility","authors":"Yan-Chao Zhang, Zi-Xin Zhuang, Fan Zhang, Xiao-Yan Song, Wen-Nan Ye, Shun-Fan Wu, Chris Bass, Andrias O. O’Reilly, Congfen Gao","doi":"10.1021/acs.est.5c02110","DOIUrl":"https://doi.org/10.1021/acs.est.5c02110","url":null,"abstract":"Nicotinic acetylcholine receptors (nAChRs) are the molecular targets of some important insecticides including triflumezopyrim and neonicotinoids. However, our understanding of insect nAChR pharmacology and the specific nAChR subunits targeted by these insecticides remains limited. Here, we cloned 11 nAChR subunit genes, comprising Nlα1 to Nlα8, Nlα10, Nlβ1 and Nlβ3, from Nilaparvata lugens, a highly damaging insect pest of rice crops worldwide. Analysis of the expression of these genes in different tissues of N. lugens by qPCR analysis identified the brain as the primary site of expression. Knock down of the expression of Nlα1, Nlα2, Nlα8 and Nlβ1 using RNAi reduced N. lugens sensitivity to triflumezopyrim, suggesting these genes encode potential target subunits for triflumezopyrim. Knock out of Nlα2 and Nlα8 nAChR subunits by CRISPR/Cas9 genome editing showed that their deletion significantly reduced the toxicity of triflumezopyrim toward N. lugens. Furthermore, the deletion of Nlα2 also increased N. lugens resistance to imidacloprid and dinotefuran. However, numerous attempts revealed that the Nlβ1 knockout was nonviable. In vitro expression of receptors composed of Drosophila homologous subunits showed that this all-insect nAChR was inhibited by nanomolar concentrations of triflumezopyrim. The present findings identify specific nAChR subunits that are important both as targets for monitoring resistance-associated mutations and as subjects for molecular studies aimed at developing novel insecticides targeting these essential ion channels.","PeriodicalId":36,"journal":{"name":"环境科学与技术","volume":"34 1","pages":""},"PeriodicalIF":9.028,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143776087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Regulating the Electronic Metal–Support Interaction of Single-Atom Ruthenium Catalysts for Boosting Chlorobenzene Oxidation

IF 9.028 1区环境科学与生态学

环境科学与技术 Pub Date : 2025-04-04 DOI: 10.1021/acs.est.5c00299

Xiaoxiao Duan, Ben Niu, Yiwen Wang, Zhenwen Yang, Hongna Ren, Ganggang Li, Zheng Wei, Jie Cheng, Zhongshen Zhang, Zhengping Hao

{"title":"Regulating the Electronic Metal–Support Interaction of Single-Atom Ruthenium Catalysts for Boosting Chlorobenzene Oxidation","authors":"Xiaoxiao Duan, Ben Niu, Yiwen Wang, Zhenwen Yang, Hongna Ren, Ganggang Li, Zheng Wei, Jie Cheng, Zhongshen Zhang, Zhengping Hao","doi":"10.1021/acs.est.5c00299","DOIUrl":"https://doi.org/10.1021/acs.est.5c00299","url":null,"abstract":"Developing highly active single-atom catalysts (SACs) with excellent chlorine resistance for efficient oxidation of harmful chlorinated volatile organic compounds (CVOCs) is a great challenge. Tuning the electronic metal–support interaction (EMSI) is viable for promoting catalytic performances of SACs. Herein, an effective strategy of modulating the EMSI in Ru1/CeO2 SACs by thermal treatment control is proposed, which distinctly enhances the activities of the catalyst for chlorobenzene (CB) oxidation and chlorine conversion, accomplishing total CB degradation at nearly 260 °C. Detailed characterization and theoretical calculations reveal that the EMSI induces electron transfer from Ru to CeO2, optimizing the coordination and electronic structure of single-atom Ru and accordingly facilitating the adsorption and activation of CB. Moreover, the surface lattice oxygen (Olatt) at the Ru–O–Ce interface is demonstrated as the critical reactive oxygen species, the mobility and reactivity of which are also prompted by the EMSI, leading to the boosted conversion of reaction intermediates. This work sheds light on the effect of EMSI regulation on CVOC catalytic oxidation and provides guidance on fabricating high-efficiency SACs for environmental catalysis.","PeriodicalId":36,"journal":{"name":"环境科学与技术","volume":"108 1","pages":""},"PeriodicalIF":9.028,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143776086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Marine Scrubbers vs Low-Sulfur Fuels: A Comprehensive Well-To-Wake Life Cycle Assessment Supported by Measurements Aboard an Ocean-Going Vessel

IF 9.028 1区环境科学与生态学

环境科学与技术 Pub Date : 2025-04-04 DOI: 10.1021/acs.est.4c10006

Patritsia M. Stathatou, Ievgenii Petrunia, Torsten Barenthin, George Gotsis, Paul Jeffrey, Christopher Fee, Scott Bergeron, Marios Tsezos, Michael Triantafyllou, Neil Gershenfeld

{"title":"Marine Scrubbers vs Low-Sulfur Fuels: A Comprehensive Well-To-Wake Life Cycle Assessment Supported by Measurements Aboard an Ocean-Going Vessel","authors":"Patritsia M. Stathatou, Ievgenii Petrunia, Torsten Barenthin, George Gotsis, Paul Jeffrey, Christopher Fee, Scott Bergeron, Marios Tsezos, Michael Triantafyllou, Neil Gershenfeld","doi":"10.1021/acs.est.4c10006","DOIUrl":"https://doi.org/10.1021/acs.est.4c10006","url":null,"abstract":"Maritime transport significantly contributes to global emissions, prompting the International Maritime Organization to implement stricter regulations to reduce pollution. Since 2020, fuel sulfur (S) content limits have been reduced, requiring either the use of low-S fuels or the installation of marine scrubbers to continue using heavy fuel oil (HFO). While scrubbers are a widely adopted solution for reducing S emissions, their benefits are controversial and uncertainty remains regarding scrubber environmental impacts and their appropriate evaluation. Here, we systematically assess the environmental impacts of scrubbers operating on HFO to those of low-S fuels across various categories, through a measurement-informed Well-to-Wake (WtW) life cycle assessment (LCA). Gaseous and particulate matter (PM) emissions data were collected while a bulk carrier vessel was burning 3% S HFO, 0.1% S marine gas oil (MGO), and 0.5% S very low-S fuel oil (VLSFO) under similar engine operating modes during an actual ocean voyage. Seawater and washwater samples were also analyzed, alongside fuel, cylinder oil, and lubricant samples. The results suggest that, in various instances the use of HFO with a scrubber can be considered equivalent to MGO use while outperforming VLSFO use from a WtW perspective, for large, ocean-going bulk carrier vessels in open seas. These findings indicate that end-of-pipe solutions may not always be inferior to start-of-pipe alternatives, underscoring the need for comprehensive LCA studies to properly assess emission abatement technologies.","PeriodicalId":36,"journal":{"name":"环境科学与技术","volume":"23 1","pages":""},"PeriodicalIF":9.028,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143776008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Artificial Intelligence for the Discovery of Safe and Effective Flame Retardants

IF 9.028 1区环境科学与生态学

环境科学与技术 Pub Date : 2025-04-04 DOI: 10.1021/acs.est.4c14787

Xiaojia Chen, Min Nian, Feng Zhao, Yu Ma, Jingzhi Yao, Siyi Wang, Xing Chen, Dan Li, Mingliang Fang

{"title":"Artificial Intelligence for the Discovery of Safe and Effective Flame Retardants","authors":"Xiaojia Chen, Min Nian, Feng Zhao, Yu Ma, Jingzhi Yao, Siyi Wang, Xing Chen, Dan Li, Mingliang Fang","doi":"10.1021/acs.est.4c14787","DOIUrl":"https://doi.org/10.1021/acs.est.4c14787","url":null,"abstract":"Organophosphorus flame retardants (OPFRs) are important chemical additives that are used in commercial products. However, owing to increasing health concerns, the discovery of new OPFRs has become imperative. Herein, we propose an explainable artificial intelligence-assisted product design (AIPD) methodological framework for screening novel, safe, and effective OPFRs. Using a deep neural network, we established a flame retardancy prediction model with an accuracy of 0.90. Employing the SHapley Additive exPlanations approach, we have identified the Morgan 507 (P═N connected to a benzene ring) and 114 (quaternary carbon) substructures as promoting units in flame retardancy. Subsequently, approximately 600 compounds were selected as OPFR candidates from the ZINC database. Further refinement was achieved through a comprehensive scoring system that incorporated absorption, toxicity, and persistence, thereby yielding six prospective candidates. We experimentally validated these candidates and identified compound Z2 as a promising candidate, which was not toxic to zebrafish embryos. Our methodological framework leverages AIPD to effectively guide the discovery of novel flame retardants, significantly reducing both developmental time and costs.","PeriodicalId":36,"journal":{"name":"环境科学与技术","volume":"58 1","pages":""},"PeriodicalIF":9.028,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143776085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Swim in Plastics: Clean Nanoplastics Cause Minimal Mortality but Alter Neurobehavioral and Molecular Rhythms in Fish

IF 9.028 1区环境科学与生态学

环境科学与技术 Pub Date : 2025-04-04 DOI: 10.1021/acs.est.4c10984

Xiaoyu Duan, Mohamed Helal, Xin Wang, Yuyue Huang, Morten Frendø Ebbesen, Jonathan Brewer, Shan Wang, Changzhu Wu, Henrik Holbech, Elvis Genbo Xu

{"title":"Swim in Plastics: Clean Nanoplastics Cause Minimal Mortality but Alter Neurobehavioral and Molecular Rhythms in Fish","authors":"Xiaoyu Duan, Mohamed Helal, Xin Wang, Yuyue Huang, Morten Frendø Ebbesen, Jonathan Brewer, Shan Wang, Changzhu Wu, Henrik Holbech, Elvis Genbo Xu","doi":"10.1021/acs.est.4c10984","DOIUrl":"https://doi.org/10.1021/acs.est.4c10984","url":null,"abstract":"Nanoplastics (NPs) pose potential ecological and health impacts. While previous studies have highlighted inconsistent toxicity levels of NPs, knowledge remains limited about the specific effects of different NPs on embryonic development, early life-stage behaviors, and bodily uptake. This study examines the effects of polystyrene NPs (PS-NPs) with different surface charges, plain polystyrene (PS), amino-modified (PS-NH2), and carboxyl-modified (PS-COOH) on zebrafish early life stages. High-resolution 3D bioimaging confirmed differential internalization: PS-COOH accumulated in the yolk and intestine, while PS-NH2 localized mainly in the intestine. PS-NPs up to 10 ppm did not significantly affect mortality or hatching rates, likely due to effective dialysis, minimizing toxic chemical leaching. PS-NP exposure led to noninflated swim bladders and affected swimming. RNA sequencing identified impacted neurological molecular pathways like circadian rhythm and visual function; weighted gene coexpression network analysis indicated strong correlations between key gene modules and phenotypic traits like eye development and dopamine level. We highlight the low acute toxicity of clean dialyzed NPs despite bodily uptake and surface-charge-dependent sublethal neurotoxicity. Overall, plain PS-NPs induced significant individual-level effects, while charged PS-NPs caused stronger molecular-level alterations; toxicity profiles varied across biological levels, complicating hazard assessment and underscoring the need for population-level studies on ecological impacts.","PeriodicalId":36,"journal":{"name":"环境科学与技术","volume":"15 1","pages":""},"PeriodicalIF":9.028,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143776171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Direct Evidence That Microplastics Are Transported to the Deep Sea by Turbidity Currents

IF 9.028 1区环境科学与生态学

环境科学与技术 Pub Date : 2025-04-04 DOI: 10.1021/acs.est.4c12007

Peng Chen, Ian A. Kane, Michael A. Clare, Euan L. Soutter, Furu Mienis, Roy A. Wogelius, Edward Keavney

{"title":"Direct Evidence That Microplastics Are Transported to the Deep Sea by Turbidity Currents","authors":"Peng Chen, Ian A. Kane, Michael A. Clare, Euan L. Soutter, Furu Mienis, Roy A. Wogelius, Edward Keavney","doi":"10.1021/acs.est.4c12007","DOIUrl":"https://doi.org/10.1021/acs.est.4c12007","url":null,"abstract":"Microplastics pervade the global seafloor, yet the mechanisms by which this pollutant is increasingly transported to the deep sea remain unclear. Fast-moving sediment avalanches (called turbidity currents) are hypothesized to efficiently transport microplastics into the deep sea. However, while this has been inferred from field sampling of the seafloor, it has never been demonstrated outside of a laboratory setting. Here, we provide direct field-scale evidence that turbidity currents in submarine canyons not only transport globally significant volumes of mineral and organic matter into the deep sea but also carry large quantities of anthropogenic particles, including microfibers and microplastic fragments. In situ hydrodynamic monitoring, coupled with direct sampling of the seafloor and material suspended by turbidity currents, reveals that even a submarine canyon whose head lies hundreds of kilometers from land acts as an efficient conduit to flush sediment and pollutants from the continental shelf to water depths greater than 3200 m. Frequent and fast turbidity currents supply oxygen and nutrients that sustain deep-sea biodiversity and fishing grounds in, and adjacent to, such canyons. Our study therefore confirms that these biodiversity hotspots are colocated with microplastic hotspots, indicating that the more than 5000 land-detached canyons worldwide can be important but previously unproven conveyors of anthropogenic pollution to the deep sea.","PeriodicalId":36,"journal":{"name":"环境科学与技术","volume":"34 1","pages":""},"PeriodicalIF":9.028,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143776009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spatially-Resolved Analysis of Water Use for Vapor Compression and Evaporative Air Conditioning Systems for Commercial Buildings in the United States.

IF 10.8 1区环境科学与生态学

环境科学与技术 Pub Date : 2025-04-03 DOI: 10.1021/acs.est.4c09452

Narmada Ponnamperuma, Sreenand Sreedevi, Jordan D Clark, Daniel B Gingerich

{"title":"Spatially-Resolved Analysis of Water Use for Vapor Compression and Evaporative Air Conditioning Systems for Commercial Buildings in the United States.","authors":"Narmada Ponnamperuma, Sreenand Sreedevi, Jordan D Clark, Daniel B Gingerich","doi":"10.1021/acs.est.4c09452","DOIUrl":"https://doi.org/10.1021/acs.est.4c09452","url":null,"abstract":"Shifting from electricity-reliant vapor compression (VC) air conditioning systems toward alternatives like evaporative cooling (EC) is one strategy being considered to reduce energy use and electricity demand associated with space cooling in the United States (U.S.). However, little work has been done to understand other environmental consequences of this potential shift. In this work, we assess the consumptive water use of these two technologies for nine commercial building archetypes across the continental U.S. To do so, we modeled on-site water use for EC, electric energy consumed by both VC and EC systems, and water consumed by electricity generation at a regional level. We find that while indirect water use for EC systems is less than that of VC systems by approximately 50%, EC systems consume around 5-8 times as much water overall, owing to their on-site water use. The largest differences occur in the hot, humid climates of the Southeastern U.S. due to the region's large cooling needs and saturated atmosphere. Together, these findings indicate the need to design EC systems that include condensation steps in more closed-loop designs.","PeriodicalId":36,"journal":{"name":"环境科学与技术","volume":" ","pages":""},"PeriodicalIF":10.8,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143770726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Size-Dependent Pulmonary Toxicity and Whole-Body Distribution of Inhaled Micro/Nanoplastic Particles in Male Mice from Chronic Exposure

IF 9.028 1区环境科学与生态学

环境科学与技术 Pub Date : 2025-04-03 DOI: 10.1021/acs.est.4c14232

Leijian Chen, Yu Liu, Huankai Li, Siyi Lin, Xiaoxiao Wang, Jiacheng Fang, Xin Diao, Lei Wang, Zhu Yang, Zongwei Cai

{"title":"Size-Dependent Pulmonary Toxicity and Whole-Body Distribution of Inhaled Micro/Nanoplastic Particles in Male Mice from Chronic Exposure","authors":"Leijian Chen, Yu Liu, Huankai Li, Siyi Lin, Xiaoxiao Wang, Jiacheng Fang, Xin Diao, Lei Wang, Zhu Yang, Zongwei Cai","doi":"10.1021/acs.est.4c14232","DOIUrl":"https://doi.org/10.1021/acs.est.4c14232","url":null,"abstract":"The ubiquitous presence of micro/nanoplastics (MP/NP) in the atmosphere has raised significant concerns about their potential health risks through inhalation, yet the effects of natural respiratory exposure remain underexplored. This study addresses this critical knowledge void by utilizing a whole-body inhalation exposure system to investigate the distribution, accumulation, and pulmonary toxicity of polystyrene MP/NP (1.5 × 105 particles/m3) in male ICR mice (n = 16/group). Fluorescently labeled MP/NP revealed the highest particle accumulation in the lungs, followed by the bloodstream and spleen, with minimal detection in the brain. Unsurprisingly, 80 nm nanoplastics displayed greater intertissue transport efficiency than 1 μm microplastics. Chronic exposure to both microplastics and nanoplastics disrupted oxidative balance and exacerbated oxidative stress within the extracellular environment of the lungs. The impaired antioxidant defenses and disrupted intra- and extracellular metabolism led to inflammation, apoptosis, and fibrosis. Intriguingly, 1 μm microplastics induced more severe pulmonary toxicity than their smaller counterparts, promoting epithelial–mesenchymal transition and fibrosis. These findings underscore the need for a nuanced understanding of size-dependent toxicities of inhalable plastic particles and highlight the health risks posed by airborne MP/NP.","PeriodicalId":36,"journal":{"name":"环境科学与技术","volume":"33 1","pages":""},"PeriodicalIF":9.028,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143776090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multiomic Landscape of Primary Hypothyroidism Induced by Subchronic Exposure to Low-Dose Novel PFOS Substitute OBS in Human and Murine Models

IF 9.028 1区环境科学与生态学

环境科学与技术 Pub Date : 2025-04-03 DOI: 10.1021/acs.est.4c10565

Wang Yang, Ke Ma, Supeng Yin, Weihua Wang, Huihui An, Yinde Huang, Hong Guo, Lin Ao, Zeyu Yang, Fan Zhang

{"title":"Multiomic Landscape of Primary Hypothyroidism Induced by Subchronic Exposure to Low-Dose Novel PFOS Substitute OBS in Human and Murine Models","authors":"Wang Yang, Ke Ma, Supeng Yin, Weihua Wang, Huihui An, Yinde Huang, Hong Guo, Lin Ao, Zeyu Yang, Fan Zhang","doi":"10.1021/acs.est.4c10565","DOIUrl":"https://doi.org/10.1021/acs.est.4c10565","url":null,"abstract":"Sodium p-perfluorous nonenoxybenzenesulfonate (OBS) as a novel surrogate for perfluorooctanesulfonate (PFOS) has been extensively utilized in industrial manufacturing and daily life. However, studies on OBS-induced environmental health risks of obstructive biosynthesis (OBS) are currently limited, particularly the risk for thyroid diseases. Following the construction of in vivo (mouse) and in vitro (normal human primary thyrocytes) models of subchronic low-dose OBS exposure, we explored the thyroid-disrupting effects of OBS through multiomics approaches and experimental validations. Our results showed that subchronic exposure to low doses of OBS led to primary hypothyroidism in mice, presenting with reduced number and functional abnormalities of thyrocytes. Further in vitro assays confirmed that low-dose OBS-induced disulfidptosis, a newly discovered form of programmed cell death, in human primary thyrocytes. Meanwhile, exposure to low-dose OBS remarkably suppressed thyroid hormone synthesis pathways in mouse and human thyrocytes. The charted multiomic landscape of OBS-induced primary hypothyroidism in mammals revealed the thyroid toxicity and endocrine-disrupting properties of OBS, suggesting that it is not a safe alternative to PFOS.","PeriodicalId":36,"journal":{"name":"环境科学与技术","volume":"183 1","pages":""},"PeriodicalIF":9.028,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143766817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0