IF 12.2 1区环境科学与生态学

环境科学与技术 Pub Date : 2026-10-20 Epub Date: 2026-10-08 DOI: 10.1021/acs.est.6c03454

Xinyi Ke, Xiaowei Huang, Nan Zhang, Xueling Yang, Yuxuan Chen, Jiawei Shao, Jiachun Shi, Jianming Xu, Yan He

{"title":"Combined Residues of Frequently Detected Herbicides are Stronger Predictors of Soil Resistome and Virulence Potential than Single Residues","authors":"Xinyi Ke, Xiaowei Huang, Nan Zhang, Xueling Yang, Yuxuan Chen, Jiawei Shao, Jiachun Shi, Jianming Xu, Yan He","doi":"10.1021/acs.est.6c03454","DOIUrl":"10.1021/acs.est.6c03454","url":null,"abstract":"Overuse of herbicides has resulted in a global epidemicof evolvedresistance in soil ecosystems. While single herbicide risk has beendocumented, the impact of multiple herbicide residues on the soilresistomes remains poorly understood. Our study quantified the residuesof 24 herbicides, profiled antibiotic resistance genes (ARGs) andvirulence factor genes (VFGs), and reconstructed 1086 metagenome-assembledgenomes (MAGs) from 93 agricultural soils across China. The analyticalresults demonstrate that the frequently detected herbicide residues(e.g., 60–90% detection frequency) are stronger predictorsof soil antibiotic resistomes than total herbicide load, unsupervisedmixture based on principal component analysis (PCA), or single-herbicidemodels. For VFG abundance, the same mixture outperformed the bestsingle herbicide and total herbicide concentration, although PCA–PC1showed a moderately stronger correlation. Specifically, these commonlydetected herbicides showed positive associations with ARG abundancethrough both direct linkages and bacterial community-dependent indirectpathways. Similar patterns were observed for virulence potential,where frequently detected residues maintained strong predictive performanceand were predominantly associated with indirect pathways. Functionalannotation patterns further suggest a concurrent enrichment of traitsrelated to antioxidant defense, mobility, adherence, and immune modulationunder elevated herbicide exposure. Notably, multiple herbicide residueswere linked to the abundance of a Trinickia taxon,which was identified as a candidate ARG-VFG co-occurrence MAG carryinga high ARG load. Our findings highlight the need to integrate compoundexposure of frequently detected herbicides into future risk assessmentmethodology for preventing the dissemination of ARGs in agriculturalsoils.","PeriodicalId":36,"journal":{"name":"环境科学与技术","volume":"60 41","pages":"29555–29568"},"PeriodicalIF":12.2,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149151403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enrofloxacin Disrupts Microbiota–Gut–Brain Axes in Marine Medaka: Mechanistic Insights from Multiomics and Germ-Free Models 恩诺沙星破坏海洋Medaka微生物-肠-脑轴：来自多组学和无菌模型的机制见解

IF 12.2 1区环境科学与生态学

环境科学与技术 Pub Date : 2026-10-20 Epub Date: 2026-10-07 DOI: 10.1021/acs.est.6c06063

Bian-Hao Zeng, Ping Li, Bin Liu, Tengzhou Li, Haiyang Yin, Le Sun, Ling Liu, Zhi-Hua Li

{"title":"Enrofloxacin Disrupts Microbiota–Gut–Brain Axes in Marine Medaka: Mechanistic Insights from Multiomics and Germ-Free Models","authors":"Bian-Hao Zeng, Ping Li, Bin Liu, Tengzhou Li, Haiyang Yin, Le Sun, Ling Liu, Zhi-Hua Li","doi":"10.1021/acs.est.6c06063","DOIUrl":"10.1021/acs.est.6c06063","url":null,"abstract":"The widespread use of antibiotics has resulted in theirfrequentoccurrence in marine environments, yet their ecological risks remainpoorly understood. Enrofloxacin (ENR) is one of the most frequentlydetected antibiotics in aquatic ecosystems. However, its toxicologicalmechanisms in marine fish remain unclear. Here, multiomics, Vibrio parahemolyticus infection, short chain fattyacid supplementation and germ-free fish models were integrated toinvestigate ENR induced neurotoxicity and the role of gut microbiota.The results showed that ENR exposure impaired intestinal functionin marine medaka (Oryzias melastigma), accompanied by behavioral abnormalities, neurotoxicity, and liverinjury. ENR also induced gut microbiome dysbiosis and altered SCFAslevels. Furthermore, SCFAs supplementation and germ-free fish experimentsprovided complementary and supportive evidence that gut microbialdysbiosis and altered SCFAs levels may be involved in ENR neurotoxicresponses. Moreover, ENR pretreated fish showed increased susceptibilityto V. parahemolyticus challenge, whichfurther disrupted the gut microbiome and aggravated neurological dysfunction.Collectively, these findings suggest that ENR induced neurotoxicityis linked to disruption of the microbiome–gut–brainaxis and increased susceptibility to subsequent pathogenic stress.This study provides new insights into antibiotic toxicity in marinefish and supports ecological risk assessment of ENR in marine aquaculture.","PeriodicalId":36,"journal":{"name":"环境科学与技术","volume":"60 41","pages":"29299–29312"},"PeriodicalIF":12.2,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149151444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tire-Derived 6PPD-Quinone in Water: Environmental Fate, Ecological Risks, and Advances in Its Mitigation 水中轮胎衍生的6ppd -醌：环境命运、生态风险及缓解进展

IF 12.2 1区环境科学与生态学

环境科学与技术 Pub Date : 2026-10-20 Epub Date: 2026-09-07 DOI: 10.1021/acs.est.6c04257

Junfei Gu, Ke Liu, Shurun Yang, Si Sun, Jiamei Liu, Xiaonan Li, Hongyu Mu, Qinxue Wen, Chuan-Shu He, Bo Lai

{"title":"Tire-Derived 6PPD-Quinone in Water: Environmental Fate, Ecological Risks, and Advances in Its Mitigation","authors":"Junfei Gu, Ke Liu, Shurun Yang, Si Sun, Jiamei Liu, Xiaonan Li, Hongyu Mu, Qinxue Wen, Chuan-Shu He, Bo Lai","doi":"10.1021/acs.est.6c04257","DOIUrl":"https://doi.org/10.1021/acs.est.6c04257","url":null,"abstract":"N-(1,3-Dimethylbutyl)-N’-phenyl-p-phenylenediamine-quinone(6PPD-Q) has been widely detected in aquatic environments and exhibitsextremely high toxicity to aquatic organisms, establishing it as theprimary culprit behind urban runoff mortality syndrome. This reviewsystematically examines its environmental migration, transformationpathways, and aquatic distribution, toxicity, and removal. The keyfindings are (1) 6PPD-Q originates mainly from tire wear and undergoeslong-range transport via runoff and atmospheric circulation, withmicrobial processes dominating its condition-dependent biotransformation.(2) It is widely detected in surface water, groundwater, sediments,and wastewater, showing pronounced spatiotemporal heterogeneity drivenby rainfall and snowmelt. (3) 6PPD-Q displays strong species-specifictoxicity, particularly to salmonids, causing acute lethality and sublethaleffects including oxidative stress, neurotoxicity, and developmentaltoxicity at environmentally relevant concentrations. (4) Removal technologiesinclude advanced oxidation, adsorption, biodegradation, and coupledapproaches. Light-driven oxidation shows promise, yet unrealisticexperimental concentrations, unknown byproduct toxicity, and economicfeasibility remain key barriers. Based on current findings and identifiedresearch gaps, we propose recommendations to deepen the understandingof the environmental implications of 6PPD-Q and guide the developmentof effective mitigation technologies.","PeriodicalId":36,"journal":{"name":"环境科学与技术","volume":"60 41","pages":"29213–29228"},"PeriodicalIF":12.2,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149218997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Psychoactive Pollutant Impacts Baseline Immune Traits but Not Behavior and Microbiome in a Fish 精神活性污染物影响鱼的基线免疫特性，但不影响行为和微生物组

IF 9.028 1区环境科学与生态学

环境科学与技术 Pub Date : 2026-10-20 DOI: 10.1021/acs.est.6c12057

Gabriel Melhado,Rhiannon V. Eastment,Francine Z. Marques,Upama Aich,Anne Peters,Bob B. M. Wong

{"title":"Psychoactive Pollutant Impacts Baseline Immune Traits but Not Behavior and Microbiome in a Fish","authors":"Gabriel Melhado,Rhiannon V. Eastment,Francine Z. Marques,Upama Aich,Anne Peters,Bob B. M. Wong","doi":"10.1021/acs.est.6c12057","DOIUrl":"https://doi.org/10.1021/acs.est.6c12057","url":null,"abstract":"Pharmaceutical pollution is an increasing global threat to freshwater ecosystems. Psychoactive drugs, such as antidepressants, are of particular concern because they affect evolutionarily conserved neuroendocrine pathways in nontarget organisms. As these pathways regulate interconnected biological systems, understanding the ecological consequences of pharmaceutical exposure requires an integrative approach. Here, we investigated the effects of 28-day exposure to control (freshwater), low (4.2 ± 0.3 ng/L), and high (637.5 ± 173.84 ng/L) fluoxetine concentrations on behaviors, baseline immune traits, and skin mucus microbiome composition in the Murray River rainbowfish (Melanotaenia fluviatilis). Fluoxetine exposure did not impact fish behavior, including activity, freezing behavior, shelter use, or microbiome composition. In contrast, immune traits were significantly altered. Both fluoxetine concentrations reduced total white blood cell (WBC) count, while only fish exposed to the low concentration showed reduced lymphocyte counts and elevated neutrophil counts, consistent with a stress-associated WBC redistribution response. Our findings show that different, but interconnected, biological systems can differ in their sensitivity to pollutants and suggest that immune traits may be an early, sensitive indicator of exposure to psychoactive pharmaceuticals. These findings highlight the importance of integrating multiple biological end points to obtain a more comprehensive understanding of the ecological consequences of pharmaceutical contamination.","PeriodicalId":36,"journal":{"name":"环境科学与技术","volume":"22 1","pages":""},"PeriodicalIF":9.028,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149221682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Landscape Fire-Sourced PM2.5 and Cause-Specific Renal Hospitalizations: A Multicountry Two-Stage Time-Series Analysis of 12.5 Million Admissions 景观火源PM2.5和病因特异性肾脏住院：对1250万入院患者的多国两阶段时间序列分析

IF 9.028 1区环境科学与生态学

环境科学与技术 Pub Date : 2026-10-20 DOI: 10.1021/acs.est.6c04677

Bo Wen,Yao Wu,Rongbin Xu,Gongbo Chen,Pei Yu,Yanming Liu,Wenhua Yu,Tingting Ye,Wenzhong Huang,Zhengyu Yang,Yiwen Zhang,Zhihu Xu,Shuang Zhou,Ke Ju,Simon Hales,Eric Lavigne,Paulo H.N. Saldiva,Micheline S.Z.S. Coelho,Patricia Matus,Kraichat Tantrakarnapa,Wissanupong Kliengchuay,Michael Abramson,Guy Marks,Lidia Morawska,Fay H. Johnston,Jane Heyworth,Geoffrey G. Morgan,Luke Knibbs,Yuming Guo,Shanshan Li

{"title":"Landscape Fire-Sourced PM2.5 and Cause-Specific Renal Hospitalizations: A Multicountry Two-Stage Time-Series Analysis of 12.5 Million Admissions","authors":"Bo Wen,Yao Wu,Rongbin Xu,Gongbo Chen,Pei Yu,Yanming Liu,Wenhua Yu,Tingting Ye,Wenzhong Huang,Zhengyu Yang,Yiwen Zhang,Zhihu Xu,Shuang Zhou,Ke Ju,Simon Hales,Eric Lavigne,Paulo H.N. Saldiva,Micheline S.Z.S. Coelho,Patricia Matus,Kraichat Tantrakarnapa,Wissanupong Kliengchuay,Michael Abramson,Guy Marks,Lidia Morawska,Fay H. Johnston,Jane Heyworth,Geoffrey G. Morgan,Luke Knibbs,Yuming Guo,Shanshan Li","doi":"10.1021/acs.est.6c04677","DOIUrl":"https://doi.org/10.1021/acs.est.6c04677","url":null,"abstract":"Landscape fire-sourced PM2.5 (LFS PM2.5) is increasingly recognized as an important air pollutant, but its short-term contribution to renal hospitalizations remains unclear. Here, we assessed the associations between LFS PM2.5 and renal hospitalizations across 1020 locations in Australia, Brazil, Canada, Chile, New Zealand, and Thailand during 2000–2019 using a two-stage time-series design and estimated the attributable hospitalizations. LFS PM2.5 was associated with increased renal hospitalization risk, with the strongest associations observed for acute kidney injury. A 10 μg/m3 increase in cumulative LFS PM2.5 exposure over lag 0–5 was associated with a 1.1% increase in renal hospitalizations (RR = 1.011, 95% CI: 1.007–1.015). Associations were stronger in warmer areas and differed across levels of GDP per capita. Associations were consistently stronger for LFS PM2.5 than for non-LFS PM2.5. We estimated that LFS PM2.5 contributed to 1.38 renal hospitalizations per 100,000 population annually across the study regions. These findings highlight renal disease as an underrecognized health consequence of landscape fire smoke and support strengthened strategies to reduce wildfire smoke exposure under a changing climate.","PeriodicalId":36,"journal":{"name":"环境科学与技术","volume":"73 1","pages":""},"PeriodicalIF":9.028,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149221687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chemical Conditioner-Free Sludge Dewatering via CO2 Hydrate Crystallization: Coupling Organic Matter Retention, Water Extraction, and Carbon Utilization 化学调理剂-无污泥脱水通过CO2水合物结晶：耦合有机物质保留，水提取，和碳利用

IF 12.2 1区环境科学与生态学

环境科学与技术 Pub Date : 2026-10-20 Epub Date: 2026-09-09 DOI: 10.1021/acs.est.6c04440

Huilian Sun, Shuai Wang, Lunxiang Zhang, Mehrdad Vasheghani Farahani, Aliakbar Hassanpouryouzband, Lei Yang, Zheng Ling, Yongchen Song

{"title":"Chemical Conditioner-Free Sludge Dewatering via CO2 Hydrate Crystallization: Coupling Organic Matter Retention, Water Extraction, and Carbon Utilization","authors":"Huilian Sun, Shuai Wang, Lunxiang Zhang, Mehrdad Vasheghani Farahani, Aliakbar Hassanpouryouzband, Lei Yang, Zheng Ling, Yongchen Song","doi":"10.1021/acs.est.6c04440","DOIUrl":"10.1021/acs.est.6c04440","url":null,"abstract":"Effective sludge dewatering is essential for reducingsludge volumeand associated transportation and disposal burdens. However, conventionalapproaches often require substantial chemical addition or energy input,increasing operating costs and potential secondary environmental impacts.Here, we present a CO2 hydrate crystallization-based dewateringapproach that avoids conventional chemical sludge conditioners. Residualwater in mechanically dewatered sludge is converted into separablesolid hydrate structures, with water molecules incorporated into hydrogen-bondedhydrate cages and sludge-derived solutes and particulates excludedfrom the hydrate lattice. Low-field nuclear magnetic resonance measurementsshowed that hydrate crystallization promoted the mobilization of mechanicallybound water, whose relative signal fraction decreased from 68.2% to40.7%. With methionine as a kinetic promoter, repeated hydrate formationand separation reduced the sludge water content to 59.3%. The screening-levelprocess electricity demand was estimated at 0.247–0.298 kWh/kgof removed water, depending on the cold energy recovery scenario.The process also retained most sludge-derived volatile solids andproduced hydrate-dissociated water with reduced aqueous constituentlevels following hydrate layer separation. These results highlightCO2 hydrate crystallization as a phase-transition-drivenstrategy for deep sludge dewatering, with energy integration and solid–liquidseparation remaining key considerations for further process development.","PeriodicalId":36,"journal":{"name":"环境科学与技术","volume":"60 41","pages":"29629–29639"},"PeriodicalIF":12.2,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148933356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Data-Driven Approach for the Development of a Time-Informed Adverse Outcome Pathway Network for the Cardiotoxicity of Environmental Chemicals 一种数据驱动的方法，用于开发一个时间信息的环境化学品心脏毒性不良结果通路网络

IF 12.2 1区环境科学与生态学

环境科学与技术 Pub Date : 2026-10-20 Epub Date: 2026-10-02 DOI: 10.1021/acs.est.6c00396

Alexandra Schaffert, Sivakumar Murugadoss, Tom Roos, Nunzia Linzalone, Gabriele Donzelli, Ronette Gehring, Birgit Mertens, Martin Paparella

{"title":"A Data-Driven Approach for the Development of a Time-Informed Adverse Outcome Pathway Network for the Cardiotoxicity of Environmental Chemicals","authors":"Alexandra Schaffert, Sivakumar Murugadoss, Tom Roos, Nunzia Linzalone, Gabriele Donzelli, Ronette Gehring, Birgit Mertens, Martin Paparella","doi":"10.1021/acs.est.6c00396","DOIUrl":"10.1021/acs.est.6c00396","url":null,"abstract":"We developed a bottom-up, data-driven approach for constructinga time-informed adverse outcome pathway (AOP) network for environmentalchemical-induced cardiotoxicity. Mechanistic end points were systematicallyextracted from 339 in vitro and in vivo studies, yielding 1759 KeyEvent (KE) entries and 4938 Key Event Relationship (KER) entries,together with study metadata and essentiality evidence from interventionexperiments. After quality filtering and minimum support thresholding,62 unique KEs and 256 unique KERs were retained for network construction.Network analysis highlighted oxidative stress and mitochondrial dysfunctionas prominent, highly connected KEs linking diverse upstream perturbationsto downstream cardiomyocyte injury, inflammation, cardiac remodeling(fibrosis and hypertrophy), decreased myocardial contractility, andreduced left ventricular function. A central methodological findingwas that temporal information was more informative at the level ofKERs than at the level of KEs. The same KE could occur across multipledurations depending on the relationship in which it was embedded,whereas KER-level time-scale annotation resolved distinct acute, subacute,and chronic pathway patterns not apparent from KE timing alone. Thisframework provides an evidence-weighted synthesis of the most consistentlysupported cardiotoxicity mechanisms and introduces a temporal layerfor the mechanistic interpretation of heterogeneous evidence.","PeriodicalId":36,"journal":{"name":"环境科学与技术","volume":"60 41","pages":"29273–29284"},"PeriodicalIF":12.2,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149091527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spatiotemporal Magnetic Decoupling Directs Spin-Dependent Cascade ROS Evolution for Electro-Fenton Water Decontamination 时空磁去耦指导自旋依赖级联ROS进化的电fenton水净化

IF 12.2 1区环境科学与生态学

环境科学与技术 Pub Date : 2026-10-20 Epub Date: 2026-10-06 DOI: 10.1021/acs.est.6c08534

Tong Xu, Pan Xia, Jingwen Wang, Jiaqin Xiao, Jun Zhai, Liying Yang, Bingbing Wang, Qiang He, Fábio Gozzi, Zhihong Ye

{"title":"Spatiotemporal Magnetic Decoupling Directs Spin-Dependent Cascade ROS Evolution for Electro-Fenton Water Decontamination","authors":"Tong Xu, Pan Xia, Jingwen Wang, Jiaqin Xiao, Jun Zhai, Liying Yang, Bingbing Wang, Qiang He, Fábio Gozzi, Zhihong Ye","doi":"10.1021/acs.est.6c08534","DOIUrl":"10.1021/acs.est.6c08534","url":null,"abstract":"Heterogeneous electro-Fenton (HEF) systems hold greatpotentialfor decentralized water purification, yet concurrently achieving highcatalytic activity, structural stability, and controlled reactiveoxygen species (ROS) selectivity remains challenging. Herein, we proposea spatiotemporal magnetic decoupling strategy to concurrently addressthese design objectives. The carbon shell spatially separated exteriorFe0 satellites from the FeNx core, eliminating deleterious short-range magnetic quenching andaltering the local magnetic environment to modulate the internal Fe(III)spin state. The resulting low-spin Fe(III) sites suppressed electronback-donation into the H2O2 σ∗antibonding orbital, favoring an additional 1O2 generation pathway. Spatial decoupling also enabled a gradient cascadeactivation of H2O2 across the Fe0 and FeNx domains, synergistically boostingthe evolution of both •OH and 1O2, with steady-state concentrations reaching 18.25 and 5.27μM, respectively. Consequently, the FeNx@C–Fe0-based HEF achieved complete naproxendegradation within 60 min with significantly suppressed Fe leaching(0.85 mg L–1), outperforming all comparative systems.Comprehensive characterizations and density functional theory (DFT)calculations established a definitive relationship between topologicalengineering and spin-state dynamics. Furthermore, the system demonstratedproof-of-concept applicability in real hospital wastewater, highlightingthe potential of spatiotemporal spin-state engineering for regulatingROS evolution in HEF systems.","PeriodicalId":36,"journal":{"name":"环境科学与技术","volume":"60 41","pages":"29651–29664"},"PeriodicalIF":12.2,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149092386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aging of Urban Traffic Fine Particles Modulates Toxicity Mechanisms and Oxidative Stress Responses 城市交通细颗粒物老化调节毒性机制和氧化应激反应

IF 12.2 1区环境科学与生态学

环境科学与技术 Pub Date : 2026-10-20 Epub Date: 2026-10-08 DOI: 10.1021/acs.est.6c06323

Michal Pardo, Noga Kozer, Carolina Molina, Yanfang Chen, Haim Barr, Galit Cohen, Damianos Pavlidis, Christos Kaltsonoudis, Katerina Seitanidi, Georgia A. Argyropoulou, Christina N. Vasilakopoulou, Christina Christopoulou, Angeliki Matrali, Mingchen Wei, Andre S. H. Prevot, David M. Bell, Spyros N. Pandis, Athanasios Nenes, Yinon Rudich

{"title":"Aging of Urban Traffic Fine Particles Modulates Toxicity Mechanisms and Oxidative Stress Responses","authors":"Michal Pardo, Noga Kozer, Carolina Molina, Yanfang Chen, Haim Barr, Galit Cohen, Damianos Pavlidis, Christos Kaltsonoudis, Katerina Seitanidi, Georgia A. Argyropoulou, Christina N. Vasilakopoulou, Christina Christopoulou, Angeliki Matrali, Mingchen Wei, Andre S. H. Prevot, David M. Bell, Spyros N. Pandis, Athanasios Nenes, Yinon Rudich","doi":"10.1021/acs.est.6c06323","DOIUrl":"10.1021/acs.est.6c06323","url":null,"abstract":"Vehicular emissions are an important source of urbanair pollutionthat can age through atmospheric processes, but how their health effectschange during atmospheric aging remains poorly understood. To simulaterealistic urban emissions, we sampled air in a parking garage wherecold-start and urban emissions coexist. Following aging in an oxidationflow reactor (OFR), we studied the cellular and acellular effectsof the fresh and aged aerosols. Photochemical aging in the OFR increasedsecondary organic aerosol (SOA) mass by up to 6.9-fold, the oxygen-to-carbon(O:C) ratio from 0.26 to 0.79, and both the intrinsic oxidative potential(OPm) and the volume-normalized oxidative potential (OPv). In contrast,the peroxide-sensitive DCF activity decreased following aging. Cellularexposure to aged aerosol extracts increased cellular reactive oxygenspecies (ROS) formation in lung (A549) and liver (HepG2) cells, whereasfresh extracts strongly reduced cellular respiration, particularlyin HepG2 cells. Cell painting analysis showed distinct morphologicalprofiles. Exposure to aged extracts showed greater oxidative stressand DNA damage responses than those of exposure to fresh extracts.These findings suggest that atmospheric aging shifts the toxicityof fresh emissions from suppression of mitochondrial respiration towardoxygenated organics that can drive intracellular oxidative stressand DNA damage phenotypes. In conclusion, atmospheric aging of cold-startand urban vehicular emissions contributes to enhanced SOA formationand leads to distinct biological outcomes that depend on the degreeof oxidative aging.","PeriodicalId":36,"journal":{"name":"环境科学与技术","volume":"60 41","pages":"29313–29324"},"PeriodicalIF":12.2,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149151402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Expansion of Freshwater Harmful Cyanobacteria in Brackish Waters: Salt Stress Responses, Toxigenic Dynamics, and Ecological Risks along the Freshwater-to-Marine Continuum 淡水有害蓝藻在咸淡水中的扩张：盐胁迫反应、产毒动力学和淡水-海洋连续体的生态风险

IF 12.2 1区环境科学与生态学

环境科学与技术 Pub Date : 2026-10-20 Epub Date: 2026-10-07 DOI: 10.1021/acs.est.6c06461

Yingying Huang, Haipeng Wu, Xiaoyang Zhang, Panyi Chen, Xinlu Li, Yixuan Zeng, Zhansen Sha, Xiaodong Jiang, Yiping Li, Hans W. Paerl, Xuechu Chen

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