Natalie J Roper,George M Hardy,Jack M Wootton,Paul G Waddell,James Wilson,Roly J Armstrong
{"title":"A multicomponent approach for the stereoselective synthesis of atropisomeric N-N peptide analogues.","authors":"Natalie J Roper,George M Hardy,Jack M Wootton,Paul G Waddell,James Wilson,Roly J Armstrong","doi":"10.1039/d5cc05091j","DOIUrl":"https://doi.org/10.1039/d5cc05091j","url":null,"abstract":"Peptide analogues featuring both central and N-N axial chirality were efficiently synthesised using a 4-component Ugi reaction. This method demonstrates a broad substrate scope, affording the target compounds with excellent stereoselectivity (up to >95 : 5 d.r.). Thermal atropisomerization studies revealed the identity of the substituents significantly influences the configurational stability and thermodynamic preferences of the atropisomeric products.","PeriodicalId":67,"journal":{"name":"Chemical Communications","volume":"119 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145277152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zihan Wu,Runlin Wang,Chunguang Shi,Dongxia Zhu,Martin R Bryce
{"title":"AIE Ir(III) complex conjugated with biotin as a photosensitizer for enhanced photodynamic anticancer therapy.","authors":"Zihan Wu,Runlin Wang,Chunguang Shi,Dongxia Zhu,Martin R Bryce","doi":"10.1039/d5cc04806k","DOIUrl":"https://doi.org/10.1039/d5cc04806k","url":null,"abstract":"The first aggregation induced emission (AIE) Ir(III) complex bearing a biotin-functionalized ligand, Ir-Bio, is reported. Ir-Bio generates type I and type II reactive oxygen species and has an excellent photodynamic therapy effect in cancer cells.","PeriodicalId":67,"journal":{"name":"Chemical Communications","volume":"40 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145277154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Plasma spray modulating porous NiAl coating on nickel mesh for hydrogen and oxygen evolution","authors":"Junjie Huang, Yuan Heng, Yuqian Yang, Lihua Gao, Zhongqin Pan, Yuhuan Yang, Xiao-Lei Huo, Changqing Ye, Qingwen Zhou","doi":"10.1039/d5cc04622j","DOIUrl":"https://doi.org/10.1039/d5cc04622j","url":null,"abstract":"n this study, a porous NiAl coated nickel mesh electrode (EPS-NA) was designed by plasma spraying and alkaline etching. The sprayed ratio of Ni and Al plays a vital role to obtain a superior and stable performance in both hydrogen evolution reaction (HER) and oxygen evolution reaction (OER). The in-situ formed NiO phase were observed in the coating and significantly accelerate the HER kinetics by promoting the Volmer step.","PeriodicalId":67,"journal":{"name":"Chemical Communications","volume":"74 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145261043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Room-temperature phosphorescence color tuning by a protonic acid doping strategy","authors":"Guowei Zhang, Chen-Sheng Li, Zhiyuan Yong, Fushun Liang, Xintong Zhang","doi":"10.1039/d5cc04443j","DOIUrl":"https://doi.org/10.1039/d5cc04443j","url":null,"abstract":"In this study, we have proposed a protonic acid doping strategy to modulate the phosphorescence color of organic/polymer host-guest doping system. Specifically, 1-naphthylamine(1-AN)-doped in poly(vinyl alcohol) (PVA) host exhibits yellow phosphorescence while green phosphorescence in poly(acrylic acid) (PAA, functions as both matrix and protonic acid). The addition of hydrochloric acid into the 1-AN@PVA system also induces a green phosphorescence. This work provides an efficient approach for phosphorescence color tuning via acid doping.","PeriodicalId":67,"journal":{"name":"Chemical Communications","volume":"89 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145255507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Daniel S. Paula, Larissa Garcia Velasco, Jean C.P. Sousa, Thiago Miguel Cardoso, Muhammad Irfan Qadir, Boniek Gontijo Vaz, Wendell Karlos Tomazelli Coltro
{"title":"Tailored Ionic Liquids for Microfluidic Paper-Based Analytical Devices: Boosting Colorimetric Performance for Enzymatic Glucose Assays via Cellulose Surface Modification","authors":"Daniel S. Paula, Larissa Garcia Velasco, Jean C.P. Sousa, Thiago Miguel Cardoso, Muhammad Irfan Qadir, Boniek Gontijo Vaz, Wendell Karlos Tomazelli Coltro","doi":"10.1039/d5cc03909f","DOIUrl":"https://doi.org/10.1039/d5cc03909f","url":null,"abstract":"Ionic liquids were used as modifiers for the paper surface, exploring their physicochemical properties to enhance hydroxyl availability and promote stronger interactions with chromogens for colorimetric assays. Paper microfluidic devices with modified surfaces were successfully tested for glucose assays, revealing enhanced colorimetric performance with a lower color gradient (20 ± 3%) and improved analytical reliability.","PeriodicalId":67,"journal":{"name":"Chemical Communications","volume":"121 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145261044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Contributors to the Emerging Investigators collection 2025: Part 2","authors":"","doi":"10.1039/d5cc90326b","DOIUrl":"https://doi.org/10.1039/d5cc90326b","url":null,"abstract":"A graphical abstract is available for this content","PeriodicalId":67,"journal":{"name":"Chemical Communications","volume":"89 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145255500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Marong Qin, Pawan Mishra, Jasmine Hind, Ian Fallis, Matthew Tredwell
{"title":"The synthesis of [18F]SynVesT-1 and [18F]SynVesT-2 from enantioenriched boronic esters","authors":"Marong Qin, Pawan Mishra, Jasmine Hind, Ian Fallis, Matthew Tredwell","doi":"10.1039/d5cc05507e","DOIUrl":"https://doi.org/10.1039/d5cc05507e","url":null,"abstract":"Enantioenrcihed [<small><sup>18</sup></small>F]SynVesT-1 and [<small><sup>18</sup></small>F]SynVesT-2 are prepared from the corresponding enantioenriched arylboronic esters and [<small><sup>18</sup></small>F]fluoride mediated by (Py)<small><sub>4</sub></small>Cu(OTf)<small><sub>2</sub></small>. The <small><sup>18</sup></small>F-reaction is optimised on an automated synthesiser to produce multi-GBq quantites of both radiotracers to support (pre)clinical imaging.","PeriodicalId":67,"journal":{"name":"Chemical Communications","volume":"2 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145255503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Emerging Trends in AI-Integrated Optical Biosensors for Point-of-Care Diagnostics: Current Status and Future Prospects","authors":"Sathishkumar Subburaj, Conghui Liu, Tailin Xu","doi":"10.1039/d5cc04899k","DOIUrl":"https://doi.org/10.1039/d5cc04899k","url":null,"abstract":"Optical biosensors have emerged as a transformative class of point-of-care diagnostic (POCD) devices, offering sensitive, specific, and rapid detection of diseases. The integration of optical biosensors with artificial intelligence (AI) brings a new revolution to the field of POCD by enabling enhanced analytical performance and real-time decision-making. The review presents an overview of the existing and upcoming prospects of AI-integrated optical biosensors with an emphasis on progress in sensor design, data science, and miniaturization. We also point out the advantages of AI algorithms, especially machine learning and deep learning, in improving the sensitivity, specificity, and multiplexing of optical biosensors during intelligent signal processing, pattern recognition, and automated decision-making. The optical biosensing techniques including SPR, fluorescence, colorimetric, and Raman-based methods, are reviewed concerning improvements facilitated by AI technology. Finally, we examine at the possibilities of integrating optical biosensors with IoT and cloud computing and critically addressed challenges related to data privacy, integration complexity, and clinical validation. To summarized, this review provides a realistic and future-oriented outlook to researchers, clinicians, and industry stakeholders interested in using AI-enhanced optical biosensors in redefining the future of POCD.","PeriodicalId":67,"journal":{"name":"Chemical Communications","volume":"33 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145255509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Bromine Sequestration by Advanced Functional Porous Materials","authors":"SAHEL FAJAL, Sujit K. Ghosh","doi":"10.1039/d5cc03718b","DOIUrl":"https://doi.org/10.1039/d5cc03718b","url":null,"abstract":"The capture and storage of bromine have garnered significant attention in recent years due to its widespread industrial applications as well as its environmental impact as pollutant. Advanced Functional Porous Materials (AFPMs)—including metal–organic frameworks (MOFs), porous organic polymers (POPs), covalent organic frameworks (COFs), and porous organic cages (POCs)—have emerged as exceptional adsorbent materials in this field. Their high surface areas, tunable porosities, controllable structures, thermal/chemical stability, versatile molecular design, and capacity for functionalization (via pre- or post-synthetic modification) make them highly promising for bromine capture. This review highlights recent advancements in AFPMs for bromine capture from both gaseous and solution phases. We analyze key strategies to enhance bromine uptake, such as redox reactions, coordination interactions, bromination, functional group oxidation, heteroatom interactions, surface area/pore volume optimization, chemical functionalization, and post-synthetic modifications. Additionally, we discuss design strategies for developing next-generation AFPMs with superior bromine adsorption performance. As research progresses, we anticipate broader adoption of these materials in bromine capture applications.","PeriodicalId":67,"journal":{"name":"Chemical Communications","volume":"54 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145255506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Base-Promoted [3 + 2] Annulation of N-Aminoisoquinolinium Derivatives with Cyclic Iodonium Ylide/2,2-Difluorovinyl Tosylate","authors":"Xiang Liu, Wen-Rong Wu, Shaohong Ma, Juan Chen, Yuan-Jie Meng, Zi-Feng Yang, Shang-Shi Zhang, Pengju Feng","doi":"10.1039/d5cc05132k","DOIUrl":"https://doi.org/10.1039/d5cc05132k","url":null,"abstract":"A base-promoted [3+2] cycloaddition between N-aminoisoquinolinium/N-aminoquinolinium derivatives and cyclic iodonium ylides/2,2-difluorovinyl tosylate has been developed, enabling efficient access to polycyclic pyrazolo[5,1-a]isoquinolines and 1-fluoropyrazolo[5,1-a]isoquinoline frameworks with good yields and broad substrate scope. Furthermore, the synthetic utility of this method was demonstrated by scale-up reactions and subsequent transformations of the resulting polycyclic products, highlighting its potential for the construction of structurally complex polycyclic N-heterocycles.","PeriodicalId":67,"journal":{"name":"Chemical Communications","volume":"74 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145255510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}