Natural Product Reports最新文献

Spiroketal natural products isolated from traditional Chinese medicine: isolation, biological activity, biosynthesis, and synthesis. 从中药中分离的螺酮类天然产物：分离、生物活性、生物合成和合成。

IF 10.2 1区化学

Natural Product Reports Pub Date : 2025-07-21 DOI: 10.1039/d5np00035a

Eilidh G Young, Freda F Li, Margaret A Brimble

引用次数: 0

Recent advances in discovery and biosynthesis of ribosomally synthesized and post-translationally modified peptides (RiPP)-derived lipopeptides. 核糖体合成和翻译后修饰肽（RiPP）衍生的脂肽的发现和生物合成的最新进展。

IF 10.2 1区化学

Natural Product Reports Pub Date : 2025-07-16 DOI: 10.1039/d5np00042d

Shumpei Asamizu

{"title":"Recent advances in discovery and biosynthesis of ribosomally synthesized and post-translationally modified peptides (RiPP)-derived lipopeptides.","authors":"Shumpei Asamizu","doi":"10.1039/d5np00042d","DOIUrl":"https://doi.org/10.1039/d5np00042d","url":null,"abstract":"Covering: This review summarizes recent advances in the discovery, biosynthesis, and bioactivity of RiPP-derived lipopeptides, covering studies published up to 2024.Ribosomally synthesized and post-translationally modified peptides (RiPPs) are a diverse superfamily of natural products unified by a common biosynthetic logic: The peptide backbone is genetically encoded, and the translated precursor peptide undergoes a series of post-translational modifications catalyzed by maturase enzymes to produce the final bioactive compound. Despite their structural complexity, RiPPs are encoded by relatively small biosynthesis gene clusters. RiPP maturase enzymes are diverse and often promiscuous, offering significant biotechnological potential. However, their lack of conserved features makes genome-based discovery of novel RiPPs challenging. Recent advances in biosynthetic understanding and genome mining techniques have led to the identification of numerous uncharacterized RiPP biosynthetic gene clusters, often flanked by genes encoding non-RiPP moieties, in microbial genomes. Leveraging this information, a new class of natural products, hybrids of RiPPs and non-RiPP elements, has recently been discovered. Among them, RiPPs bearing fatty acyl groups, referred to as RiPP-derived lipopeptides, represent a newly emerging class of lipopeptide natural products with significant antimicrobial activity.","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":" ","pages":""},"PeriodicalIF":10.2,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144641286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Green genes from blue greens: challenges and solutions to unlocking the potential of cyanobacteria in drug discovery. 来自蓝色绿色的绿色基因：挑战和解决方案，以解锁药物发现蓝藻的潜力。

IF 10.2 1区化学

Natural Product Reports Pub Date : 2025-07-15 DOI: 10.1039/d5np00016e

Benjamin Philmus, Nicole E Avalon, Yousong Ding, Drew T Doering, Alessandra S Eustáquio, William H Gerwick, Hendrik Luesch, Jimmy Orjala, Shaz Sutherland, Arnaud Taton, Daniel Udwary

引用次数: 0

Natural products targeting the metabolism of amino acids: from discovery to synthetic development. 针对氨基酸代谢的天然产物：从发现到合成发展。

IF 10.2 1区化学

Natural Product Reports Pub Date : 2025-07-11 DOI: 10.1039/d5np00039d

Hyun Su Kim, Ahmed H E Hassan, Kyuho Moon, Jaehoon Sim

{"title":"Natural products targeting the metabolism of amino acids: from discovery to synthetic development.","authors":"Hyun Su Kim, Ahmed H E Hassan, Kyuho Moon, Jaehoon Sim","doi":"10.1039/d5np00039d","DOIUrl":"https://doi.org/10.1039/d5np00039d","url":null,"abstract":"Covering: up to 2025Amino acids constitute the essential components of biological systems. Over the recent years, there has been a growing interest in exploring amino acid metabolism as a source of novel druggable targets for intractable diseases such as cancer, metabolic disorders, and degenerative diseases. Culminating research has unveiled novel therapeutic targets associated with amino acid metabolism, including glutamine, cysteine, arginine, and tryptophan metabolism. The pursuit of therapeutic drug targets has resulted in the discovery of potential modulators showing promise for the development of new drug candidates. Many of these modulators have been derived from natural products, employing diverse methods such as traditional medical knowledge, high-throughput screening, and bioinformatics approaches. Based on these discoveries, a variety of synthetic analogues have been developed to improve pharmacological profiles, target selectivity, and drug-like properties. Structural optimization of natural product scaffolds, including derivatization, bioisostere incorporation, and prodrug strategies, has enabled the rational design of potent inhibitors targeting amino acid metabolism. These efforts have expanded the utility of naturally occurring inhibitors, offering enhanced efficacy and therapeutic potential. In this review, we systematically categorize natural products that target enzymes involved in amino acid metabolism, highlighting the recent advances in their development as medicinal agents. This work aims to provide a valuable resource for researchers by outlining the therapeutic potential of natural products and identifying opportunities for future investigation.","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":" ","pages":""},"PeriodicalIF":10.2,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144612051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Progress on targeted discovery of microbial natural products based on the predictions of both structure and activity. 基于结构和活性预测的微生物天然产物定向发现研究进展。

IF 10.2 1区化学

Natural Product Reports Pub Date : 2025-07-08 DOI: 10.1039/d5np00008d

Yuwei Zhang, Jianfa Zong, Yufeng Liu, Keyu Zhou, Haibo Shi, Wen-Bing Yin, Ling Liu, Yihua Chen

引用次数: 0

Engineering modular enzyme assembly: synthetic interface strategies for natural products biosynthesis applications. 工程模块化酶组装：天然产物生物合成应用的合成界面策略。

IF 10.2 1区化学

Natural Product Reports Pub Date : 2025-06-27 DOI: 10.1039/d5np00027k

Gahyeon Kim, Dukwon Lee, Ji Hun Kim, Seong Do Kim, Hongki Kim, Jae Heon Kim, Sung Sun Yim, Soo-Jin Yeom, Jay D Keasling, Byung-Kwan Cho

{"title":"Engineering modular enzyme assembly: synthetic interface strategies for natural products biosynthesis applications.","authors":"Gahyeon Kim, Dukwon Lee, Ji Hun Kim, Seong Do Kim, Hongki Kim, Jae Heon Kim, Sung Sun Yim, Soo-Jin Yeom, Jay D Keasling, Byung-Kwan Cho","doi":"10.1039/d5np00027k","DOIUrl":"https://doi.org/10.1039/d5np00027k","url":null,"abstract":"Covering: 2020 to 2025Natural products remain indispensable sources of therapeutic and bioactive compounds, yet traditional discovery strategies are constrained by compound rediscovery. Modular biosynthetic enzymes, such as type I polyketide synthases (PKSs) and type A non-ribosomal peptide synthetases (NRPSs), offer promising platforms for combinatorial biosynthesis owing to their programmable architectures. However, practical implementation is frequently limited by inter-modular incompatibility and domain-specific interactions. This review highlights recent advances in modular enzyme assembly enabled by synthetic interfaces-including cognate docking domains, synthetic coiled-coils, SpyTag/SpyCatcher, and split inteins-which function as orthogonal, standardized connectors to facilitate post-translational complex formation. These interfaces support rational investigations into substrate specificity, module compatibility, and pathway derivatization as well as general enzyme clustering applications beyond PKS and NRPS systems. Synthetic interfaces can be integrated with computational tools to support a more systematic and scalable framework for modular enzyme engineering by providing predictive insights into domain compatibility and interface design. These approaches within iterative design-build-test-learn workflows can accelerate the programmable assembly of biosynthetic systems and expand the accessible chemical space for natural products.","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":" ","pages":""},"PeriodicalIF":10.2,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144504239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The ballet of nature: the interconvertible isomerisation of natural products. 大自然的芭蕾：天然产物的可转换异构化。

IF 10.2 1区化学

Natural Product Reports Pub Date : 2025-06-23 DOI: 10.1039/d5np00019j

Ze-Jun Xu, Jing-Jing Han, Chun-Yang Zhang, Hong-Xiang Lou

引用次数: 0

The chemical and biological properties of natural resorcylic acid lactones. 天然间环酸内酯的化学和生物学特性。

IF 10.2 1区化学

Natural Product Reports Pub Date : 2025-06-19 DOI: 10.1039/d5np00033e

Ying Gao, Wanpeng Li, Hanli Ruan

引用次数: 0

Mass spectrometry-based metabolomics approaches to interrogate host-microbiome interactions in mammalian systems. 基于质谱的代谢组学方法在哺乳动物系统中询问宿主-微生物组相互作用。

IF 10.2 1区化学

Natural Product Reports Pub Date : 2025-06-16 DOI: 10.1039/d5np00021a

Atharva S Kulkarni, Guilherme M P Carrara, Jiangpeiyun Jin, Jarrod Laro, Thilini Peramuna, Laura-Isobel McCall, Neha Garg

{"title":"Mass spectrometry-based metabolomics approaches to interrogate host-microbiome interactions in mammalian systems.","authors":"Atharva S Kulkarni, Guilherme M P Carrara, Jiangpeiyun Jin, Jarrod Laro, Thilini Peramuna, Laura-Isobel McCall, Neha Garg","doi":"10.1039/d5np00021a","DOIUrl":"10.1039/d5np00021a","url":null,"abstract":"Covering: 2015 to 2025Chemical crosstalk is universal to all life, niche-specific, and essential to thrive. This crosstalk is mediated by a large diversity of molecules, including metal ions, small molecules, polysaccharides, nucleic acids, lipids, and proteins. Among these, specialized small molecules referred to as natural products (NPs) play an important role in microbe-drug/environment interactions, microbe-microbe, and microbe-host interactions. Microbial communication using NPs allows microbes to sense quorum, form biofilms, eliminate competition, establish symbiosis, evade immune attack, and respond to stress. In most cases, the elucidation of small molecule mediators and effectors of microbe-host interactions presents a major challenge due to the relatively low abundance of microbial metabolites in a milieu of host, microbe, and environmental metabolites. Advances in analytical instrumentation, such as mass spectrometers, and both experimental as well as computational methods to analyze data, coupled with the use of model organisms, have enabled fundamental discoveries of mechanisms of small molecule-mediated host-microbe interactions. The focus of this review is to detail the approaches applied in the last decade to disentangle microbiome-derived NPs in human and murine model systems. Select recent findings from diverse biological ecosystems are discussed to inform relevant parallels and potential strategies for research in human health.","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":" ","pages":""},"PeriodicalIF":10.2,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12169106/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144300750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring microbial natural products through NMR-based metabolomics. 通过核磁共振代谢组学探索微生物天然产物。

IF 10.2 1区化学

Natural Product Reports Pub Date : 2025-06-12 DOI: 10.1039/d4np00065j

De-Gao Wang, Jia-Qi Hu, Chao-Yi Wang, Teng Liu, Yue-Zhong Li, Changsheng Wu

{"title":"Exploring microbial natural products through NMR-based metabolomics.","authors":"De-Gao Wang, Jia-Qi Hu, Chao-Yi Wang, Teng Liu, Yue-Zhong Li, Changsheng Wu","doi":"10.1039/d4np00065j","DOIUrl":"https://doi.org/10.1039/d4np00065j","url":null,"abstract":"Covering: 2000. 01 to 2025. 03The soaring demand for novel drugs has led to an increase in the requirement for smart methods to aid in the exploration of microbial natural products (NPs). Cutting-edge metabolomics excels at prompt identification of compounds from complex mixtures and accordingly accelerates the targeted discovery process. Although MS-based metabolomics has become a staple in this field, the utilization of NMR-based metabolomics has severely trailed in comparison. Herein, we summarize the key methodological advancements in 1D and 2D NMR techniques in the past two decades, especially for the invention of computational technologies and/or introduction of artificial intelligence for automated data processing, which significantly strengthen the ability of NMR-based metabolomics to analyze crude microbial extracts. Preliminary fractionation is advocated to deconvolute samples and thus enhance detection sensitivity towards minor components overshadowed by a complex matrix. Particularly, the synergistic application of NMR-based metabolomics and genomics provides an expedient approach to correlate biosynthetic gene clusters with cognate metabolites, greatly improving the efficiency of dereplication and, thus, targeted discovery of novel compounds. A variety of microbial NPs involving distinct chemical skeletons and/or biosynthetic logics are enumerated to prove the genuine prowess of NMR-based metabolomics. Overall, this review aims to encourage the broader adoption of NMR-based metabolomics in the realm of microbial NP research.","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":" ","pages":""},"PeriodicalIF":10.2,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144273676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0