Natural Product Reports最新文献

{"title":"The chemical and biological properties of natural resorcylic acid lactones.","authors":"Ying Gao, Wanpeng Li, Hanli Ruan","doi":"10.1039/d5np00033e","DOIUrl":"https://doi.org/10.1039/d5np00033e","url":null,"abstract":"<p><p>Covering: 1953 to Feb 2025Resorcylic acid lactones (RALs) represent a significant category of polyketides characterized by a β-resorcylate unit embedded in a macrolactone ring. Since the discovery of radicicol in 1953, over 300 natural RALs have been identified, showcasing remarkable structural diversity and a wide range of pharmacological activities, including antitumor, antimalarial, antifungal, and immunomodulatory effects. RALs target multiple molecular pathways, such as heat shock protein 90 (HSP90), WNT-5A, pyruvate dehydrogenase kinase 2 (PDK2), mitogen-activated protein kinase (MAPK), and peroxiredoxin 1 (PRDX1). Despite their promising pharmacological profiles, the clinical development of RALs has progressed at a sluggish pace. This review comprehensively catalogs all natural RALs reported to date, explores their bioactivity mechanisms, and critically assesses preclinical and clinical progress. By addressing gaps in mechanistic understanding and translational research, this work highlights the challenges in drug-like properties and clinical applicability, offering valuable insights for future RAL research.</p>","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":" ","pages":""},"PeriodicalIF":10.2,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144323840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mass spectrometry-based metabolomics approaches to interrogate host-microbiome interactions in mammalian systems.","authors":"Atharva S Kulkarni, Guilherme M P Carrara, Jiangpeiyun Jin, Jarrod Laro, Thilini Peramuna, Laura-Isobel McCall, Neha Garg","doi":"10.1039/d5np00021a","DOIUrl":"10.1039/d5np00021a","url":null,"abstract":"<p><p>Covering: 2015 to 2025Chemical crosstalk is universal to all life, niche-specific, and essential to thrive. This crosstalk is mediated by a large diversity of molecules, including metal ions, small molecules, polysaccharides, nucleic acids, lipids, and proteins. Among these, specialized small molecules referred to as natural products (NPs) play an important role in microbe-drug/environment interactions, microbe-microbe, and microbe-host interactions. Microbial communication using NPs allows microbes to sense quorum, form biofilms, eliminate competition, establish symbiosis, evade immune attack, and respond to stress. In most cases, the elucidation of small molecule mediators and effectors of microbe-host interactions presents a major challenge due to the relatively low abundance of microbial metabolites in a milieu of host, microbe, and environmental metabolites. Advances in analytical instrumentation, such as mass spectrometers, and both experimental as well as computational methods to analyze data, coupled with the use of model organisms, have enabled fundamental discoveries of mechanisms of small molecule-mediated host-microbe interactions. The focus of this review is to detail the approaches applied in the last decade to disentangle microbiome-derived NPs in human and murine model systems. Select recent findings from diverse biological ecosystems are discussed to inform relevant parallels and potential strategies for research in human health.</p>","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":" ","pages":""},"PeriodicalIF":10.2,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12169106/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144300750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring microbial natural products through NMR-based metabolomics.","authors":"De-Gao Wang, Jia-Qi Hu, Chao-Yi Wang, Teng Liu, Yue-Zhong Li, Changsheng Wu","doi":"10.1039/d4np00065j","DOIUrl":"https://doi.org/10.1039/d4np00065j","url":null,"abstract":"<p><p>Covering: 2000. 01 to 2025. 03The soaring demand for novel drugs has led to an increase in the requirement for smart methods to aid in the exploration of microbial natural products (NPs). Cutting-edge metabolomics excels at prompt identification of compounds from complex mixtures and accordingly accelerates the targeted discovery process. Although MS-based metabolomics has become a staple in this field, the utilization of NMR-based metabolomics has severely trailed in comparison. Herein, we summarize the key methodological advancements in 1D and 2D NMR techniques in the past two decades, especially for the invention of computational technologies and/or introduction of artificial intelligence for automated data processing, which significantly strengthen the ability of NMR-based metabolomics to analyze crude microbial extracts. Preliminary fractionation is advocated to deconvolute samples and thus enhance detection sensitivity towards minor components overshadowed by a complex matrix. Particularly, the synergistic application of NMR-based metabolomics and genomics provides an expedient approach to correlate biosynthetic gene clusters with cognate metabolites, greatly improving the efficiency of dereplication and, thus, targeted discovery of novel compounds. A variety of microbial NPs involving distinct chemical skeletons and/or biosynthetic logics are enumerated to prove the genuine prowess of NMR-based metabolomics. Overall, this review aims to encourage the broader adoption of NMR-based metabolomics in the realm of microbial NP research.</p>","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":" ","pages":""},"PeriodicalIF":10.2,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144273676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Natural products in antiparasitic drug discovery: advances, opportunities and challenges.","authors":"Xiaofei Shang, Lixia Dai, Xinyuan Cao, Yudong Ma, Ilgekbayeva Gulnaz, Xiaolou Miao, Xiuhui Li, Xiaorong Yang","doi":"10.1039/d5np00007f","DOIUrl":"https://doi.org/10.1039/d5np00007f","url":null,"abstract":"<p><p>Covering: up to 2024.Parasites infect hundreds of millions of people, result in significant disability rates and mortality and lead to devastating social and economic consequences, especially in developing countries and regions. Traditional medicines have been used for centuries to treat parasitic diseases. Some natural products (NPs) and their derivatives have been derived from these medicines and applied in clinical settings, attracting the attention of the scientific community throughout history. With the development and application of revolutionized technologies over the past few years, more promising compounds have been found from natural resources and provided new possibilities for the development of novel antiparasitic drugs. In this review, we aimed to discuss the strategies used for developing drugs from natural resources and mainly describe the causative pathogens, epidemiology and current treatment of parasitic diseases. Promising NPs and their derivatives are listed, and their effectiveness, potential mechanism and structural optimization are described. Subsequently, the advantages and limitations of the drug development process and the role of technologies in this process are discussed. A prospective analysis of research on and development of antiparasitic drugs based on NPs is presented. The high attrition rates, accessibility, sustainable supply, IP constraints and other problems still hinder the development of NPs; however, the therapeutic significance and broad clinical utilization of approved natural product-derived drugs, exemplified by quinine, artemisinin, and ivermectin in treating parasitic diseases, underscore that natural products remain a highly promising reservoir of chemical agents. Their exceptional structural diversity and marked bioactivities continue to stimulate scientific interest in novel antiparasitic drug discovery. In combination with the recent development and application of revolutionized technologies, NPs will provide a stronger basis for drug discovery and will continue to provide major contributions to human and veterinary health.</p>","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":" ","pages":""},"PeriodicalIF":10.2,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144273677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Discovery, structure revision, synthesis, and application of all known and even unknown securingine alkaloids.","authors":"Chungwoo Lee, Sunkyu Han","doi":"10.1039/d5np00025d","DOIUrl":"https://doi.org/10.1039/d5np00025d","url":null,"abstract":"<p><p>Covering: up to 2025Natural product-based research encompasses the discovery, structure elucidation, biosynthesis, synthesis, and application of naturally occurring secondary metabolites. Securingine alkaloids, isolated from <i>Flueggea suffruticosa</i>, have emerged as valuable molecular frameworks for exploring various aspects of natural product research due to their distinct chemical structures, characterized by unique oxidation and rearrangement patterns. Herein, we provide a comprehensive account of our journey in developing novel synthetic strategies and tactics for accessing all known and even unknown securingines and investigating the potential application of securingine B as a novel class of natural product-based molecular photoswitches.</p>","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":" ","pages":""},"PeriodicalIF":10.2,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144256861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends in metabolite discovery from <i>Actinomycetes</i>.","authors":"Paolo Monciardini, Matteo Simone, Marianna Iorio, Sonia I Maffioli, Margherita Sosio, Stefano Donadio","doi":"10.1039/d4np00075g","DOIUrl":"https://doi.org/10.1039/d4np00075g","url":null,"abstract":"<p><p>Covering: 2013 to 2023In this review, we analyzed the scientific literature of the period 2013-2023 that reported novel specialized metabolites from the <i>Actinomycetes</i>, one of the most prolific producers of natural products. The discovered metabolites were categorized on the basis of their chemical originality into two groups: variants of known molecules, or original metabolites. In addition, we subdivided the approaches used to discover these metabolites into four categories: bioassay-based screening, genome mining, metabolome mining, or combinations thereof. We present selected examples of the different approaches used and the resulting original metabolites. Finally, we measure the overall trends of discovery in terms of approaches, of the frequency of original metabolites and of the major biosynthetic classes that have been described. Overall, our analysis indicates that new metabolites continue to be discovered from <i>Actinomycetes</i> at a relatively constant rate and that the frequency of original metabolites seems to be approach-independent and relatively constant within the analyzed time period.</p>","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":" ","pages":""},"PeriodicalIF":10.2,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144245337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in the discovery and study of <i>Trichoderma</i> natural products for biological control applications.","authors":"Sophie Jin, Fabrizio Alberti","doi":"10.1039/d5np00017c","DOIUrl":"10.1039/d5np00017c","url":null,"abstract":"<p><p>Covering: up to 2025Reducing the prevalence of phytopathogens and their impact on crops is essential to reach sustainable agriculture goals. Synthetic pesticides have been commonly used to control crop disease but are now strongly linked to disease resistance, environmental pollution, depletion of soil biodiversity, and bioaccumulation, leading to adverse effects on human health. As a alternative, the prolific <i>Trichoderma</i> genus has been studied for its biocontrol properties, as well as its ability to promote plant growth and increase nutrient uptake. This is done through various mechanisms, one of which is the production of bioactive natural products with high chemical diversity. These include terpenoids, alkaloids, non-ribosomal peptides, polyketides and RiPPs. One of the most studied examples is 6-pentyl-2<i>H</i>-pyran-2-one, a volatile organic polyketide, which induces systemic acquired resistance, morphogenesis, and natural product biosynthesis in plants. Methods for culturing <i>Trichoderma</i> spp., isolating and characterising unique bioactive metabolites are discussed here, with an emphasis on dereplication strategies using metabolomics to optimise discovery. In addition, the role of genome mining for the study of natural product biosynthesis in <i>Trichoderma</i>, and more generally, filamentous fungi is discussed. Examples of bioinformatics tools available to date are listed here with applications in <i>Trichoderma</i> and other ascomycetes. New advances in genome engineering in <i>Trichoderma</i> are also detailed, providing insights into available strategies for the validation of biosynthetic gene clusters identified using genome mining. Finally, the use of a combination of omics approaches, namely metabologenomics, is presented as a growing field for natural product discovery in fungi.</p>","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":" ","pages":""},"PeriodicalIF":10.2,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12142736/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144232716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hot off the Press","authors":"Robert A. Hill and Andrew Sutherland","doi":"10.1039/D5NP90022K","DOIUrl":"10.1039/D5NP90022K","url":null,"abstract":"<p >A personal selection of 32 recent papers is presented covering various aspects of current developments in bioorganic chemistry and novel natural products, such as shimianolide A from <em>Chloranthus holostegius</em> var. <em>shimianensis</em>.</p>","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":" 6","pages":" 945-949"},"PeriodicalIF":10.2,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144223779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary substances and their glucuronides: structures, occurrence and biological activity.","authors":"Andrew V Stachulski, Edwin A Yates, Aleksandra Teriosina, Lesley Hoyles, Simon McArthur","doi":"10.1039/d5np00002e","DOIUrl":"10.1039/d5np00002e","url":null,"abstract":"<p><p>Covering up to 2025.Plant-derived polyphenols of various chemical classes are widely distributed in dietary substances, <i>e.g.</i> fruits, nuts, vegetables and teas. Such phenolic derivatives are natural antioxidants and have been linked with numerous health benefits, notably anti-cancer and anti-inflammatory properties. Additionally, they may behave as mild estrogens, as in the case of genistein. However, there has often been no clear correlation between <i>in vitro</i> properties, as measured in cell lines for instance, and <i>in vivo</i> performance. Moreover, it is not always clear what the true active species might be, as most phenols are readily subject to phase II metabolism, generating predominantly glucuronides and sulfates. In this highlight, we seek to address the question of whether dietary substance metabolites, especially glucuronides, which have been more widely studied, do indeed possess distinct activities in their own right compared to their parent substances. In most cases this will refer to enzyme inhibition and/or interaction with cell lines. General observations concerning glucuronidation are provided, accompanied by practical comments concerning the synthesis of glucuronides, which are not always available or marketed in useful quantities. The main structural classes of natural polyphenols are introduced, with comments including synthetic details and biological properties for important members of each class.</p>","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":" ","pages":""},"PeriodicalIF":10.2,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144214409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Technological developments driving industrial natural product discovery.","authors":"Richard Lewis, Richard Hammond, Mark Wilkinson, Nick Allenby","doi":"10.1039/d4np00072b","DOIUrl":"10.1039/d4np00072b","url":null,"abstract":"<p><p>Covering: up to 2025Bacterial natural products have long been the foundation for many therapeutic agents. However, traditional culture-based approaches to discovering these products have been deprioritised by pharmaceutical companies, primarily due to the high rates of rediscovery. To revitalise the pipeline of new drugs, especially antibiotics-an area where natural products have historically played a crucial role-new technologies are essential. Culture-independent, or metagenomic, techniques combined with long-read sequencing technologies are now enabling the identification of novel biosynthetic gene clusters (BGCs). When paired with the heterologous expression of DNA extracted directly from environmental samples (eDNA), these approaches may provide access to untapped microbial biosynthetic diversity. This review explores industrial screening for new compounds and examines how modern technologies such as metagenomics, <i>in situ</i> cultivation, and pico-droplet-based screening are advancing the search for novel natural products. These approaches have the potential to greatly expand the discovery of new bioactive compounds, helping to address the growing need for new therapeutic agents.</p>","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":" ","pages":""},"PeriodicalIF":10.2,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144214335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}