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Chemical case studies from natural products of recent interest in the crop protection industry 作物保护行业近期关注的天然产品化学案例研究
IF 11.9 1区 化学
Natural Product Reports Pub Date : 2024-09-19 DOI: 10.1039/d4np00035h
Georg Späth, Olivier Loiseleur
{"title":"Chemical case studies from natural products of recent interest in the crop protection industry","authors":"Georg Späth, Olivier Loiseleur","doi":"10.1039/d4np00035h","DOIUrl":"https://doi.org/10.1039/d4np00035h","url":null,"abstract":"Covering: up to 2024","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":null,"pages":null},"PeriodicalIF":11.9,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142267346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Current and emerging tools and strategies for the identification of bioactive natural products in complex mixtures 鉴定复杂混合物中生物活性天然产品的现有和新兴工具与策略
IF 11.9 1区 化学
Natural Product Reports Pub Date : 2024-09-18 DOI: 10.1039/d4np00006d
Manon Meunier, Andreas Schinkovitz, Séverine Derbré
{"title":"Current and emerging tools and strategies for the identification of bioactive natural products in complex mixtures","authors":"Manon Meunier, Andreas Schinkovitz, Séverine Derbré","doi":"10.1039/d4np00006d","DOIUrl":"https://doi.org/10.1039/d4np00006d","url":null,"abstract":"Covering: up to 2024","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":null,"pages":null},"PeriodicalIF":11.9,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142267347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Regulation of daptomycin biosynthesis in Streptomyces roseosporus: new insights from genomic analysis and synthetic biology to accelerate lipopeptide discovery and commercial production 玫瑰孢链霉菌中达托霉素生物合成的调控：从基因组分析和合成生物学中获得新见解，加速脂肽的发现和商业化生产
IF 11.9 1区 化学
Natural Product Reports Pub Date : 2024-09-16 DOI: 10.1039/d4np00024b
Richard H. Baltz
{"title":"Regulation of daptomycin biosynthesis in Streptomyces roseosporus: new insights from genomic analysis and synthetic biology to accelerate lipopeptide discovery and commercial production","authors":"Richard H. Baltz","doi":"10.1039/d4np00024b","DOIUrl":"https://doi.org/10.1039/d4np00024b","url":null,"abstract":"Covering 2005–2024","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":null,"pages":null},"PeriodicalIF":11.9,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142267349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Structural diversity and chemical logic underlying the assembly of monoterpene indole alkaloids oligomers 单萜吲哚生物碱低聚物组装的结构多样性和化学逻辑
IF 11.9 1区 化学
Natural Product Reports Pub Date : 2024-09-12 DOI: 10.1039/d4np00011k
Pierre Le Pogam, Mehdi A. Beniddir
{"title":"Structural diversity and chemical logic underlying the assembly of monoterpene indole alkaloids oligomers","authors":"Pierre Le Pogam, Mehdi A. Beniddir","doi":"10.1039/d4np00011k","DOIUrl":"https://doi.org/10.1039/d4np00011k","url":null,"abstract":"Covering: up to 2024","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":null,"pages":null},"PeriodicalIF":11.9,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142178808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recent advances in the biosynthetic studies of bacterial organoarsenic natural products. 细菌有机砷天然产物生物合成研究的最新进展。
IF 10.2 1区 化学
Natural Product Reports Pub Date : 2024-08-28 DOI: 10.1039/d4np00036f
Shotaro Hoshino, Hiroyasu Onaka, Ikuro Abe
{"title":"Recent advances in the biosynthetic studies of bacterial organoarsenic natural products.","authors":"Shotaro Hoshino, Hiroyasu Onaka, Ikuro Abe","doi":"10.1039/d4np00036f","DOIUrl":"https://doi.org/10.1039/d4np00036f","url":null,"abstract":"<p><p>Covering: 1977 to presentArsenic is widely distributed throughout terrestrial and aquatic environments, mainly in highly toxic inorganic forms. To adapt to environmental inorganic arsenic, bacteria have evolved ubiquitous arsenic metabolic strategies by combining arsenite methylation and related redox reactions, which have been extensively studied. Recent reports have shown that some bacteria have specific metabolic pathways associated with structurally and biologically unique organoarsenic natural products. In this highlight, by exemplifying the cases of oxo-arsenosugars, arsinothricin, and bisenarsan, we summarize recent advances in the identification and biosynthesis of bacterial organoarsenic natural products. We also discuss the potential discoveries of novel arsenic-containing natural products of bacterial origins.</p>","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":null,"pages":null},"PeriodicalIF":10.2,"publicationDate":"2024-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142078517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Empowering natural product science with AI: leveraging multimodal data and knowledge graphs. 用人工智能增强自然产品科学：利用多模态数据和知识图谱。
IF 10.2 1区 化学
Natural Product Reports Pub Date : 2024-08-16 DOI: 10.1039/d4np00008k
David Meijer, Mehdi A Beniddir, Connor W Coley, Yassine M Mejri, Meltem Öztürk, Justin J J van der Hooft, Marnix H Medema, Adam Skiredj
{"title":"Empowering natural product science with AI: leveraging multimodal data and knowledge graphs.","authors":"David Meijer, Mehdi A Beniddir, Connor W Coley, Yassine M Mejri, Meltem Öztürk, Justin J J van der Hooft, Marnix H Medema, Adam Skiredj","doi":"10.1039/d4np00008k","DOIUrl":"10.1039/d4np00008k","url":null,"abstract":"<p><p>Artificial intelligence (AI) is accelerating how we conduct science, from folding proteins with AlphaFold and summarizing literature findings with large language models, to annotating genomes and prioritizing newly generated molecules for screening using specialized software. However, the application of AI to emulate human cognition in natural product research and its subsequent impact has so far been limited. One reason for this limited impact is that available natural product data is multimodal, unbalanced, unstandardized, and scattered across many data repositories. This makes natural product data challenging to use with existing deep learning architectures that consume fairly standardized, often non-relational, data. It also prevents models from learning overarching patterns in natural product science. In this Viewpoint, we address this challenge and support ongoing initiatives aimed at democratizing natural product data by collating our collective knowledge into a knowledge graph. By doing so, we believe there will be an opportunity to use such a knowledge graph to develop AI models that can truly mimic natural product scientists' decision-making.</p>","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":null,"pages":null},"PeriodicalIF":10.2,"publicationDate":"2024-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11327853/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141986907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Retraction: Recent advances in total synthesis of protoberberine and chiral tetrahydroberberine alkaloids 撤回：原小檗碱和手性四氢小檗碱全合成的最新进展。
IF 10.2 1区 化学
Natural Product Reports Pub Date : 2024-08-16 DOI: 10.1039/D4NP90039A
Zhen-Xi Niu, Ya-Tao Wang and Jun-Feng Wang
{"title":"Retraction: Recent advances in total synthesis of protoberberine and chiral tetrahydroberberine alkaloids","authors":"Zhen-Xi Niu, Ya-Tao Wang and Jun-Feng Wang","doi":"10.1039/D4NP90039A","DOIUrl":"10.1039/D4NP90039A","url":null,"abstract":"<p >Retraction of ‘Recent advances in total synthesis of protoberberine and chiral tetrahydroberberine alkaloids’ by Zhen-Xi Niu <em>et al.</em>, <em>Nat. Prod. Rep.</em>, 2024, https://doi.org/10.1039/d4np00016a.</p>","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":null,"pages":null},"PeriodicalIF":10.2,"publicationDate":"2024-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2024/np/d4np90039a?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141986908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparing total chemical synthesis and total biosynthesis routes to fungal specialized metabolites. 比较真菌特殊代谢物的全化学合成和全生物合成途径。
IF 10.2 1区 化学
Natural Product Reports Pub Date : 2024-08-15 DOI: 10.1039/d4np00015c
Dong-Song Tian, Xiao Zhang, Russell J Cox
{"title":"Comparing total chemical synthesis and total biosynthesis routes to fungal specialized metabolites.","authors":"Dong-Song Tian, Xiao Zhang, Russell J Cox","doi":"10.1039/d4np00015c","DOIUrl":"https://doi.org/10.1039/d4np00015c","url":null,"abstract":"<p><p>Covering the period 1965-2024Total synthesis has been defined as the art and science of making the molecules of living Nature in the laboratory, and by extension, their analogues. At the extremes, specialised metabolites can be created by total chemical synthesis or by total biosynthesis. In this review we explore the advantages and disadvantages of these two approaches using quantitative methodology that combines measures of molecular complexity, molecular weight and fraction of sp<sup>3</sup> centres for bioactive fungal metabolites. Total biosynthesis usually involves fewer chemical steps and those steps move more directly to the target than comparable total chemical synthesis. However, total biosynthesis currently lacks the flexibility of chemical synthesis and the ability to easily diversify synthetic routes.</p>","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":null,"pages":null},"PeriodicalIF":10.2,"publicationDate":"2024-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141981257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biosynthesis, biological activities, and structure–activity relationships of decalin-containing tetramic acid derivatives isolated from fungi 从真菌中分离出的含蜕皮激素的四元酸衍生物的生物合成、生物活性和结构-活性关系。
IF 10.2 1区 化学
Natural Product Reports Pub Date : 2024-08-14 DOI: 10.1039/d4np00013g
{"title":"Biosynthesis, biological activities, and structure–activity relationships of decalin-containing tetramic acid derivatives isolated from fungi","authors":"","doi":"10.1039/d4np00013g","DOIUrl":"10.1039/d4np00013g","url":null,"abstract":"<div><p>Covering: up to December 2023</p></div><div><p>Decalin-containing tetramic acid derivatives, especially 3-decalinoyltetramic acids (3-DTAs), are commonly found as fungal secondary metabolites. Numerous biological activities of this class of compounds, such as antibiotic, antiviral, antifungal, antiplasmodial, and antiprotozoal properties, have been the subject of ongoing research. For this reason, these molecules have attracted a lot of interest from the scientific community and various efforts including semi-synthesis, co-culturing with bacteria and biosynthetic gene sequencing have been made to obtain more derivatives. In this review, 3-DTAs are classified into four major groups based on the absolute configuration of the bicyclic decalin ring. Their biosynthetic pathways, various biological activities, and structure–activity relationship are then introduced.</p></div>","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":null,"pages":null},"PeriodicalIF":10.2,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141445623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Architecture of full-length type I modular polyketide synthases revealed by X-ray crystallography, cryo-electron microscopy, and AlphaFold2 通过 X 射线晶体学、冷冻电镜和 AlphaFold2 揭示全长 I 型模块化多酮合成酶的结构。
IF 10.2 1区 化学
Natural Product Reports Pub Date : 2024-08-14 DOI: 10.1039/d3np00060e
{"title":"Architecture of full-length type I modular polyketide synthases revealed by X-ray crystallography, cryo-electron microscopy, and AlphaFold2","authors":"","doi":"10.1039/d3np00060e","DOIUrl":"10.1039/d3np00060e","url":null,"abstract":"<div><p>Covering: up to the end of 2023</p></div><div><p>Type I modular polyketide synthases construct polyketide natural products in an assembly line-like fashion, where the growing polyketide chain attached to an acyl carrier protein is passed from catalytic domain to catalytic domain. These enzymes have immense potential in drug development since they can be engineered to produce non-natural polyketides by strategically adding, exchanging, and deleting individual catalytic domains. In practice, however, this approach frequently results in complete failures or dramatically reduced product yields. A comprehensive understanding of modular polyketide synthase architecture is expected to resolve these issues. We summarize the three-dimensional structures and the proposed mechanisms of three full-length modular polyketide synthases, Lsd14, DEBS module 1, and PikAIII. We also describe the advantages and limitations of using X-ray crystallography, cryo-electron microscopy, and AlphaFold2 to study intact type I polyketide synthases.</p></div>","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":null,"pages":null},"PeriodicalIF":10.2,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140157126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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