Natural Product Reports最新文献

Immunomodulatory natural products via toll-like receptor 2 signalling: from agonists to inhibitors across diverse natural sources. 通过toll样受体2信号传导的免疫调节天然产物：从激动剂到抑制剂，跨越多种天然来源。

IF 12.5 1区化学

Natural Product Reports Pub Date : 2026-11-05 DOI: 10.1039/d6np00080k

Jeongho Lee

{"title":"Immunomodulatory natural products via toll-like receptor 2 signalling: from agonists to inhibitors across diverse natural sources.","authors":"Jeongho Lee","doi":"10.1039/d6np00080k","DOIUrl":"https://doi.org/10.1039/d6np00080k","url":null,"abstract":"Covering: up to 2025Toll-like receptor 2 (TLR2) is a versatile pattern recognition receptor whose activity can be tuned in either direction-agonism or antagonism-to produce distinct therapeutic outcomes, ranging from vaccine adjuvants and cancer immunotherapeutics to anti-inflammatory agents for sepsis, neuroinflammation, and autoimmune disease. Natural products from bacteria, fungi, plants, and marine organisms have emerged as a structurally rich source of TLR2 modulators, encompassing acylated lipopeptides, glycolipids, polysaccharides, flavonoids, non-flavonoid polyphenols, an aromatic aldehyde, an aporphine alkaloid, and even large bacterial antagonist proteins. This review surveys these natural TLR2 agonists and inhibitors, highlighting how the effective allocation of hydrophobic chains between the TLR2 pocket and its partner receptor, rather than total acyl-chain number alone, combines with chain branching, stereochemical presentation and polar head-group interactions to govern TLR1/TLR6 heterodimer selectivity among bacterial and gut-commensal lipids, and how mechanistically distinct inhibitory strategies-direct receptor competition, transcriptional downregulation, and TIR-domain interference-converge on a shared druggable interface exploited independently by plant polyphenols and staphylococcal virulence factors alike. Persistent experimental challenges are also discussed, including microbial contamination of natural extracts and structural heterogeneity of isolated lipids, along with how total synthesis and chemically defined oligomers have resolved these ambiguities, underscoring natural products as a promising yet still underexploited chemical space for developing selective TLR2-targeted therapeutics.","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":" ","pages":""},"PeriodicalIF":12.5,"publicationDate":"2026-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149331756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

YqcI/YcgG heme monooxygenases: a new fold for guanidine N-oxygenation in natural product biosynthesis. YqcI/YcgG血红素单加氧酶：天然产物生物合成中胍氮氧合的新途径。

IF 12.5 1区化学

Natural Product Reports Pub Date : 2026-11-04 DOI: 10.1039/d6np00089d

Darwin D Lara, Yang Hai

引用次数: 0

Natural products from human-associated microbiota in human diseases. 人类疾病中与人类相关的微生物群的天然产物。

IF 12.5 1区化学

Natural Product Reports Pub Date : 2026-11-02 DOI: 10.1039/d6np00068a

Hyeon-Seong Lee, Jungro Lee, Hoseong Hwang, Hyojune Park, Won Kyu Kim, Munhyung Bae, Jaeyoung Kwon

{"title":"Natural products from human-associated microbiota in human diseases.","authors":"Hyeon-Seong Lee, Jungro Lee, Hoseong Hwang, Hyojune Park, Won Kyu Kim, Munhyung Bae, Jaeyoung Kwon","doi":"10.1039/d6np00068a","DOIUrl":"https://doi.org/10.1039/d6np00068a","url":null,"abstract":"Covering: 1985 to 2026The human microbiota harbors abundant metabolic capacity, producing and transforming a chemically diverse array of small molecules that range from well-characterized classes, such as short-chain fatty acids, secondary bile acids, and indoles, to structurally complex ribosomal and non-ribosomal peptides. Several of these metabolites act on defined host receptors and signaling pathways, linking microbial metabolic activity to a broad spectrum of human diseases. Although individual compounds have increasingly been linked to defined host targets, this rapidly growing evidence remains scattered across disease areas. Here, we review bioactive compounds produced or transformed by human-associated microbiota, together with microbiota-associated co-metabolites, across four major disease categories, namely metabolic diseases, cancers, immune regulation, and other systemic and extraintestinal diseases. For each, we discuss the microbial species implicated, the compounds they produce, and the mechanistic evidence connecting individual molecules to disease-relevant biological processes. Altogether, we highlight the therapeutic potential of microbiota-derived metabolites and the rich opportunities for discovery within the largely untapped microbial chemical space by integrating chemistry, microbiology, and disease mechanisms. Beyond the disease-centered organization, we compare these molecules across structural and biosynthetic origins, taxonomic producer patterns, and emerging discovery strategies to identify recurring principles that cut across individual disease categories.","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":" ","pages":""},"PeriodicalIF":12.5,"publicationDate":"2026-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149316150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Opines: origins, roles, structures with a nomenclature proposal, and syntheses. 观点：起源、角色、具有命名建议的结构和综合。

IF 12.5 1区化学

Natural Product Reports Pub Date : 2026-10-21 DOI: 10.1039/d6np00028b

Leon Otten, Patrick Pale

{"title":"Opines: origins, roles, structures with a nomenclature proposal, and syntheses.","authors":"Leon Otten, Patrick Pale","doi":"10.1039/d6np00028b","DOIUrl":"10.1039/d6np00028b","url":null,"abstract":"Covering: 1927 to 2026.Although discovered almost a century ago, opines represent an ever-growing family of natural products, derived from a variety of organisms, including bacteria, fungi, plants, and marine invertebrates. Opines exhibit a wide variety of structures and play numerous biological roles, some of which have had significant implications in molecular biology, notably in the development of genetically modified organisms (GMOs) and in plant evolution with the recent discovery of natural GMOs. The opines structurally related to N-alkylated α-amino acids are useful chiral building blocks for the pharmaceutical and fine chemical industries, and some of the enzymes involved in their biosynthesis are now being exploited in these industries for drug development. This review first traces the history of opines from 1927 up to now in term of both chemical and biological views; then a new classification with clearer names is proposed mostly based on structural grounds. The various syntheses of opines are described and discussed according to this proposed classification, together with their known applications in biology, chemical biology and chemistry. Finally, several possible directions are highlighted as a roadmap for future research.","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":" ","pages":"2084-2124"},"PeriodicalIF":12.5,"publicationDate":"2026-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148596702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Radical-mediated cross-linking enzymes in RiPP biosynthesis. 自由基介导的RiPP生物合成中的交联酶。

IF 12.5 1区化学

Natural Product Reports Pub Date : 2026-10-21 DOI: 10.1039/d6np00029k

Jabal Rahmat Haedar, Ying Shi, Mit A Bhatt, Jonathan R Chekan, Huan Wang, Chin-Soon Phan

引用次数: 0

Unifying ten tryptophan dimer families: linkage diversity from bio-synthetic hypotheses to total synthesis and bioactivity. 统一十个色氨酸二聚体家族：从生物合成假说到全合成和生物活性的连锁多样性。

IF 12.5 1区化学

Natural Product Reports Pub Date : 2026-10-21 DOI: 10.1039/d6np00021e

Leiyang Bai, Haiping Liu, Xuefeng Jiang

{"title":"Unifying ten tryptophan dimer families: linkage diversity from bio-synthetic hypotheses to total synthesis and bioactivity.","authors":"Leiyang Bai, Haiping Liu, Xuefeng Jiang","doi":"10.1039/d6np00021e","DOIUrl":"10.1039/d6np00021e","url":null,"abstract":"Covering: up to July 2026Dimeric tryptophan alkaloids represent a structurally diverse family of natural products whose three-dimensional architectures and biological activities are fundamentally dictated by the linkage patterns between the two tryptophan-derived units. In this review, we connect ten seemingly unrelated natural product families through the unifying principle of tryptophan dimerization, with biological activities varying considerably across linkage types. They are systematically classified according to their covalent connectivity-C-N, C-C, or mixed C-C/C-N linkages-covering ten distinct linkage types: C3-N1', C3a-C3a' (symmetric and unsymmetric), C3-C5', C5-C5', C3-C6', C3-C7', C6-N1', C7-N1', and N1-N1'. For each class, we critically compare total syntheses reported from 1999 to 2026, with an emphasis on strategic solutions to the formidable synthetic challenges faced, e.g. the stereocontrolled formation of congested quaternary centers, chemo- and regioselective installation of heterodimeric linkages, and construction of intricate polycyclic frameworks. We further present a unified biosynthetic hypothesis for all ten linkage types, grounded in radical- and cation-mediated dimerization pathways and supported by recent enzyme characterization and synthetic studies, which not only rationalizes the known linkages but can also guide the discovery of new dimerization modes and their total syntheses, aiming to provide a comprehensive and critical overview of these dimeric tryptophan alkaloids.","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":" ","pages":"2014-2048"},"PeriodicalIF":12.5,"publicationDate":"2026-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148547111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The golden decade of eburnamine-vincamine alkaloid synthesis: 2015 to present. 电子烟胺-长春胺生物碱合成的黄金十年：2015年至今。

IF 12.5 1区化学

Natural Product Reports Pub Date : 2026-10-21 DOI: 10.1039/d6np00054a

Huijing Wang, Jiayi Mu, Yangyang Zhong, Pei Tang, Fener Chen

引用次数: 0

Ortho-alkyl phenylalkenoyl natural products: structural diversity, bioactivities and biosynthesis. 邻烷基苯烯基天然产物：结构多样性、生物活性和生物合成。

IF 12.5 1区化学

Natural Product Reports Pub Date : 2026-10-21 DOI: 10.1039/d6np00053c

Qianfei Huang, Xuxiang Chen, Shuhong Ma, Zilin Li, Peng Sun

{"title":"Ortho-alkyl phenylalkenoyl natural products: structural diversity, bioactivities and biosynthesis.","authors":"Qianfei Huang, Xuxiang Chen, Shuhong Ma, Zilin Li, Peng Sun","doi":"10.1039/d6np00053c","DOIUrl":"10.1039/d6np00053c","url":null,"abstract":"Covering: up to 2026.Ortho-alkyl phenylalkenoyl-containing natural products, including cinnamoyl-containing nonribosomal peptides (CCNPs) and ortho-alkyl phenylalkenoic acids (APAs), are structurally and biologically diverse bacterial metabolites that have become a major focus of natural product research. These metabolites exhibit broad bioactivities, including antimicrobial, antiangiogenic, cytotoxic, anti-inflammatory, and nematicidal effects. Biosynthetically, CCNPs and APAs share a conserved, highly reduced (HR) type II polyketide synthase (PKS)-derived framework, featuring characteristic isoenzymes (ISOs) and specialised cyclases that assemble the ortho-alkyl phenylalkenoyl core. They diverge fundamentally in pathway architecture: CCNPs contain NRPS-synthesised peptide backbones, whereas APAs lack NRPS components and possess expanded KS/CLF pairs. Biosynthetic studies have revealed novel mechanisms (e.g., isomerization, 6π-electrocyclisation) and multifunctional enzymes, providing valuable biocatalysts for synthetic biology. Although their biological activities depend strongly on structural context, emerging evidence highlights these metabolites as a promising source of lead compounds. Continued interdisciplinary efforts integrating natural product chemistry, biosynthesis, and medicinal chemistry are expected to unlock their therapeutic potential.","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":" ","pages":"2049-2083"},"PeriodicalIF":12.5,"publicationDate":"2026-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148589600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hot off the Press. 刚出版的。

IF 12.5 1区化学

Natural Product Reports Pub Date : 2026-10-21 DOI: 10.1039/d6np90036d

Robert A Hill, Andrew Sutherland

引用次数: 0

Natural products shape microbial ecology and disease in the cystic fibrosis airway. 天然产物在囊性纤维化气道中形成微生物生态和疾病。

IF 12.5 1区化学

Natural Product Reports Pub Date : 2026-10-21 DOI: 10.1039/d6np00067c

Niladri Bhowmik, Reed M Stubbendieck

{"title":"Natural products shape microbial ecology and disease in the cystic fibrosis airway.","authors":"Niladri Bhowmik, Reed M Stubbendieck","doi":"10.1039/d6np00067c","DOIUrl":"10.1039/d6np00067c","url":null,"abstract":"Covering up to 2026Cystic fibrosis (CF) is a life-shortening autosomal recessive genetic disorder caused by mutation in the gene encoding the CF transmembrane conductance regulator (CFTR). Dysfunction in CFTR leads to the accumulation of thick and dehydrated mucus in the respiratory tract, which serves as a substrate for a complex microbiota that includes commensal oral and respiratory bacteria and opportunistic pathogenic bacteria and fungi. During chronic infections, these microbes persist in the airways and contribute to progressive lung tissue damage, ultimately leading to respiratory failure and premature death. Within this environment, microbes synthesize a diverse repertoire of natural products, including antimicrobials, siderophores and other metallophores, signaling molecules, toxins, and other virulence factors. In this review, we thoroughly discuss natural products produced by members of the CF airway microbiota, primarily the bacterial pathogens Burkholderia spp., Pseudomonas aeruginosa, and Staphylococcus aureus and the fungal pathogens Aspergillus fumigatus and Scedosporium spp. When known, we describe the biosynthesis and roles of these natural products in microbial persistence, interspecies interactions, and virulence in the CF airway. When these roles are unknown, we infer potential roles based on evidence from the literature in different disease contexts. Finally, we briefly highlight natural products produced by the CF microbiota as novel sources for developing new antimicrobials and as drug targets to treat disease.","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":" ","pages":""},"PeriodicalIF":12.5,"publicationDate":"2026-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13684122/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149230867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0