Natural Product Reports最新文献

Remodeling of ribosomally synthesized peptide backbones based on posttranslational modifications. 基于翻译后修饰的核糖体合成肽骨架的重塑。

IF 10.2 1区化学

Natural Product Reports Pub Date : 2025-05-20 DOI: 10.1039/d5np00018a

Yanqing Xue, Yijiao Xiong, Wei Huang, Jianing Liu, Wen Liu

{"title":"Remodeling of ribosomally synthesized peptide backbones based on posttranslational modifications.","authors":"Yanqing Xue, Yijiao Xiong, Wei Huang, Jianing Liu, Wen Liu","doi":"10.1039/d5np00018a","DOIUrl":"https://doi.org/10.1039/d5np00018a","url":null,"abstract":"Covering: 2013-2024Benefiting significantly from recent advances in genome mining, ribosomally synthesized and posttranslationally modified peptide (RiPP) natural products have emerged as a source of chemical inspiration to drive the discovery of therapeutic agents and the development of new biological tools for addressing challenges to synthetic approaches. Despite being confined to twenty proteinogenic amino acid building blocks, the structural complexity and diversity of RiPPs that arise from enzymatic posttranslational modifications (PTMs) surpass expectations and are now believed to be comparable to those produced by non-ribosomal peptide synthetases. Here, we highlight the PTM enzymes characterized over the past decade that engage the -(NH-Cα-CO)n- repeating units in transformations, particularly those leading to structural rearrangements by peptide backbone remodeling. Unveiling the catalytic mechanisms of these unusual PTM enzymes deepens the understanding in RiPP biosynthesis and, eventually, will enhance our capability of rational design, development and production of functional peptide agents using synthetic biology strategies.","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":" ","pages":""},"PeriodicalIF":10.2,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144109175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent insights into the biosynthesis and biological activities of the peptide-derived redox cofactor mycofactocin. 肽衍生的氧化还原辅助因子分枝杆菌素的生物合成和生物活性的最新见解。

IF 10.2 1区化学

Natural Product Reports Pub Date : 2025-05-16 DOI: 10.1039/d5np00012b

Mark Ellerhorst, Vadim Nikitushkin, Walid K Al-Jammal, Lucas Gregor, Ivan Vilotijević, Gerald Lackner

{"title":"Recent insights into the biosynthesis and biological activities of the peptide-derived redox cofactor mycofactocin.","authors":"Mark Ellerhorst, Vadim Nikitushkin, Walid K Al-Jammal, Lucas Gregor, Ivan Vilotijević, Gerald Lackner","doi":"10.1039/d5np00012b","DOIUrl":"https://doi.org/10.1039/d5np00012b","url":null,"abstract":"Covering: 2011 to 2025The importance of redox cofactors like nicotinamide adenine dinucleotide or flavin adenine dinucleotide as cofactors for enzymatic reactions in living organisms is widely known. However, many microbial species also employ unusual redox cofactors such as the coenzyme F420 or the peptide-derived pyrroloquinoline quinone (PQQ). In this review, we introduce the reader to the recently discovered bacterial redox cofactor mycofactocin (MFT), a valine-tyrosine-derived small molecule of the class of ribosomally synthesized and post-translationally modified peptides (RiPPs) with remarkable biosynthetic and functional similarities to PQQ. The cofactor plays an important role in the reoxidation of non-exchangeable nicotinamide redox cofactors of specialized oxidoreductases in mycobacteria and related actinobacteria. We highlight the bioinformatic discovery of the mycofactocin gene cluster and its auxiliary genes, present strategies for the chemical synthesis of the cofactor, and take a detailed look at the biosynthesis of the glycosylated molecule. Subsequently, the diverse mycofactocin-inducing conditions and associated oxidoreductase families are reviewed, and a potential electron transfer route from high-energy alcohols via mycofactocin to oxygen as a final electron acceptor is presented. The review concludes with a comparison of the physiological roles of PQQ and MFT, and an outlook for future research questions and potential biotechnological applications of mycofactocin.","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":" ","pages":""},"PeriodicalIF":10.2,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144075115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prenylated bacterial natural products: occurrence, chemical diversity, biosynthesis and bioactivity. 戊烯基化细菌天然产物：发生、化学多样性、生物合成和生物活性。

IF 10.2 1区化学

Natural Product Reports Pub Date : 2025-05-15 DOI: 10.1039/d5np00011d

Fan Zhang, Di Zhao, Yuzhu Wu, Lei Li

引用次数: 0

Recent highlights of the total synthesis of cyclic peptide natural products. 近期重点介绍环肽天然产物的全合成。

IF 10.2 1区化学

Natural Product Reports Pub Date : 2025-05-14 DOI: 10.1039/d4np00056k

Takayuki Doi, Masaya Kumashiro, Kosuke Ohsawa

引用次数: 0

Recent advances in the chemistry and biology of plant oxylipin hormones. 植物氧脂素激素的化学和生物学研究进展。

IF 10.2 1区化学

Natural Product Reports Pub Date : 2025-04-25 DOI: 10.1039/d5np00006h

Yuho Nishizato, Taichi Okumura, Kotaro Matsumoto, Minoru Ueda

引用次数: 0

Unlocking marine treasures: isolation and mining strategies of natural products from sponge-associated bacteria. 解锁海洋宝藏：从海绵相关细菌中分离和开采天然产物的策略。

IF 10.2 1区化学

Natural Product Reports Pub Date : 2025-04-25 DOI: 10.1039/d5np00013k

Jeong-A Kim, Si-Sun Choi, Jae Kyu Lim, Eung-Soo Kim

引用次数: 0

Configurational assignments of type-I polyketide synthase (PKS)-derived natural products based on spectroscopic and chemical analysis: methodologies and case studies. 基于光谱和化学分析的i型聚酮合成酶（PKS）衍生天然产物的构型分配：方法和案例研究。

IF 10.2 1区化学

Natural Product Reports Pub Date : 2025-04-23 DOI: 10.1039/d4np00061g

Jinsheng Cui, Prima F Hillman, Geum Jin Kim, Thinh T M Bui, Kyuho Moon, Sang-Jip Nam, Hyukjae Choi, Dong-Chan Oh

引用次数: 0

Unpacking policy developments in marine natural product research: a scientist's guide to DSI and BBNJ. 海洋天然产品研究的政策发展：DSI和BBNJ的科学家指南。

IF 10.2 1区化学

Natural Product Reports Pub Date : 2025-04-17 DOI: 10.1039/d4np00070f

Federica Casolari, Amelia Westmoreland, Thomas Vanagt, Marcel Jaspars

{"title":"Unpacking policy developments in marine natural product research: a scientist's guide to DSI and BBNJ.","authors":"Federica Casolari, Amelia Westmoreland, Thomas Vanagt, Marcel Jaspars","doi":"10.1039/d4np00070f","DOIUrl":"https://doi.org/10.1039/d4np00070f","url":null,"abstract":"Covering: 2014 up to February 2025Since the Nagoya Protocol came into force in 2014, scientists working with genetic resources have integrated compliance with Access and Benefit-Sharing (ABS) legislation at international and national levels into their research practices. However, two key gaps left by the Nagoya Protocol are being addressed, introducing new obligations for marine natural product scientists: under the auspices of the Convention on Biological Diversity (CBD), a compromise agreement was reached in November 2024 that regulates the use of Digital Sequence Information (DSI) on Genetic Resources. Within the next few years, the 2023 Biodiversity Beyond National Jurisdiction (BBNJ) Agreement is expected to take effect. This treaty covers the access to and use of marine biodiversity of areas beyond national jurisdiction for research and development. In a time when genetic research and marine biodiversity are key to scientific advancement, these evolving policies affect how genetic information is stored, shared, and used, raising emerging questions for the scientific community about their direct impact and the complexities of compliance. Despite continuous developments and scientific community involvement, there remains a notable gap in communication between policy changes and their accessible dissemination to researchers. Addressing this gap is crucial for the continuation of research and the effective use of relevant resources. The main goal of this viewpoint article is to provide a concise guide to recent policy developments relevant to natural product researchers that should be incorporated and harmonized into ongoing scientific activities.","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":" ","pages":""},"PeriodicalIF":10.2,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143956609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthetic biology strategies for cyanobacterial systems to heterologously produce cyanobacterial natural products. 合成生物学策略的蓝藻系统异种生产蓝藻天然产物。

IF 10.2 1区化学

Natural Product Reports Pub Date : 2025-04-16 DOI: 10.1039/d5np00009b

Manyun Chen, Dipesh Dhakal, Campbell W Eckhardt, Hendrik Luesch, Yousong Ding

{"title":"Synthetic biology strategies for cyanobacterial systems to heterologously produce cyanobacterial natural products.","authors":"Manyun Chen, Dipesh Dhakal, Campbell W Eckhardt, Hendrik Luesch, Yousong Ding","doi":"10.1039/d5np00009b","DOIUrl":"https://doi.org/10.1039/d5np00009b","url":null,"abstract":"Covering: 2014 to 2024Cyanobacteria are prolific producers of bioactive natural products, including promising drug leads for FDA-approved cancer therapeutics. Advances in genome sequencing and computational tools have revealed a wealth of cyanobacterial biosynthetic gene clusters (BGCs). However, progress in genome-driven discovery has been hindered by challenges in manipulating native hosts and the limited availability of efficient heterologous expression platforms. This highlight focuses on recent synthetic biology innovations on cyanobacterial systems that address these obstacles, facilitating the production of diverse cyanobacterial natural product families. We discuss key features of widely used cyanobacterial chassis, such as Synechocystis sp. PCC 6803, Synechococcus elongatus UTEX 2973, Anabaena sp. PCC 7120, and emerging hosts. Advances in BGC cloning, combinatorial biosynthesis, transcriptional and translational regulation, and host engineering are also highlighted. Together, these synthetic biology developments provide a powerful framework for expanding cyanobacterial natural product discovery and production.","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":" ","pages":""},"PeriodicalIF":10.2,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12002140/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143951908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Modulators of the ubiquitin-proteasome system from natural products: chemical structures and their potential for drug discovery. 天然产物中泛素-蛋白酶体系统的调节剂：化学结构及其药物发现的潜力。

IF 10.2 1区化学

Natural Product Reports Pub Date : 2025-04-14 DOI: 10.1039/d5np00004a

Yuki Hitora, Sachiko Tsukamoto

{"title":"Modulators of the ubiquitin-proteasome system from natural products: chemical structures and their potential for drug discovery.","authors":"Yuki Hitora, Sachiko Tsukamoto","doi":"10.1039/d5np00004a","DOIUrl":"https://doi.org/10.1039/d5np00004a","url":null,"abstract":"Covering: up to 2024The ubiquitin-proteasome system (UPS) plays a key role in regulating intracellular protein degradation and maintaining cellular homeostasis. Within the UPS, target proteins are polyubiquitinated through sequential reactions catalyzed by ubiquitination-related enzymes. These ubiquitinated proteins are then recognized and degraded by the 26S proteasome. Deubiquitinating enzymes cleave the formed polyubiquitin chains and regulate protein degradation, thereby contributing to precise regulation of the system. Dysregulation of the UPS is associated with cancer, immune disorders, and neurodegenerative diseases, making it a potential target for drug discovery. To date, a variety of natural products that target the UPS have been discovered and used in pharmaceutical development, and these compounds have provided important insights into the molecular mechanisms of UPS regulation. This review describes natural products that inhibit protein degradation in the UPS and activate protein degradation mediated by the 20S proteasome, thus clarifying their mechanisms of action and exploring their potential applications as therapeutic agents.","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":" ","pages":""},"PeriodicalIF":10.2,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143958516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0