Natural Product Reports最新文献

Hot off the Press. 刚出版的。

IF 10.6 1区化学

Natural Product Reports Pub Date : 2025-10-01 DOI: 10.1039/d5np90038g

Robert A Hill, Andrew Sutherland

引用次数: 0

Ryanodane diterpenes: occurrence, structural diversity, bioactivities, and synthesis. 红烷二萜：发生、结构多样性、生物活性和合成。

IF 10.6 1区化学

Natural Product Reports Pub Date : 2025-10-01 DOI: 10.1039/d5np00052a

Bodou Zhang, Jingwen Zhao, Sheng Li, Hong Liang, Xiaojiang Hao, Yu Zhang

{"title":"Ryanodane diterpenes: occurrence, structural diversity, bioactivities, and synthesis.","authors":"Bodou Zhang, Jingwen Zhao, Sheng Li, Hong Liang, Xiaojiang Hao, Yu Zhang","doi":"10.1039/d5np00052a","DOIUrl":"https://doi.org/10.1039/d5np00052a","url":null,"abstract":"Covering: 1948 to 2025Ryanodane diterpenes (RDs) are a unique class of plant-derived natural products characterized by their complex, polyoxygenated pentacyclic frameworks. They have been primarily identified in plants from the Salicaceae and Lauraceae families. In recent years, RDs have garnered significant interest due to their notable bioactivities, particularly their modulation of ryanodine receptors (RyRs) and their insecticidal properties. Since the initial isolation of ryanodine from the shrub Ryania speciosa Vahl in 1948, a total of 135 natural RDs across nine subtypes have been discovered. These compounds exhibit a range of biological activities, including insecticidal, cardiac activity, and immunomodulatory effects. However, the limited natural abundance of RDs has posed challenges for their comprehensive biological evaluation. Fascinated by their high affinity for RyRs and their intricate polycyclic structures, synthetic chemists have pursued the total synthesis of RDs since the 1990s, with notable progress in recent decades. Advances in synthetic methodology have enabled the successful construction of key RD scaffolds, facilitating further exploration of their biological potential. This review provides a comprehensive overview of RDs from 1948 to May of 2025, highlighting their significance in drug discovery and development. It also emphasizes the need for interdisciplinary collaboration to fully harness the therapeutic potential of these complex natural products.","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":" ","pages":""},"PeriodicalIF":10.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145197371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Structures, biosynthetic pathways, and biological significance of bacterial aryl-heterocycle metallophores with emphasis on yersiniabactin-type derivatives. 细菌芳基杂环金属分子的结构、生物合成途径和生物学意义，重点研究耶尔希菌素类衍生物。

IF 10.6 1区化学

Natural Product Reports Pub Date : 2025-09-30 DOI: 10.1039/d5np00045a

Martinus de Kruijff, Sebastian Götze, Christine Beemelmanns

{"title":"Structures, biosynthetic pathways, and biological significance of bacterial aryl-heterocycle metallophores with emphasis on yersiniabactin-type derivatives.","authors":"Martinus de Kruijff, Sebastian Götze, Christine Beemelmanns","doi":"10.1039/d5np00045a","DOIUrl":"https://doi.org/10.1039/d5np00045a","url":null,"abstract":"Covering: up to 2025Metallophores are metal-chelating natural products produced by microorganisms to scavenge essential metal ions in nutrient-limited environments. Among them, yersiniabactin-type metallophores (YTMs) represent a structurally and functionally distinct subgroup with a growing role in host-microbe and microbe-microbe interactions. In contrast to flexible hydroxamate- and carboxylate-type siderophores, YTMs feature a linear, pre-organized arrangement of aryl and five-membered heterocycles, often derived from modular nonribosomal peptide synthetase (NRPS) pathways in combination with polyketide synthase (PKS) domains. Their biosynthesis is encoded by gene clusters that integrate precursor formation, assembly line machinery, and metal transport components. Salicylic acid-derived aryl units and cysteine/serine-derived heterocycles are tailored through oxidation, methylation, and glycosylation, giving rise to complex chelators with a broad metal-binding profile-including Cu(II), Co(II), Ni(II), and Zn(II)-but weaker Fe(III) affinity. Due to structural ambiguity in current terminology, we propose a refined definition for YTMs based on specific connectivity of aryl and heterocyclic units and demonstrated metal chelation. We distinguish YTMs from simpler aryl-hetaryl siderophores such as anguibactin and pre-acinetobactin, and argue against broader umbrella terms like \"mixed\" or \"salicyl-capped\" siderophores. This review provides a comprehensive overview of the structural, biosynthetic, and genomic features of YTMs and introduces a classification framework based on a comprehensive biosynthetic pathway survey to facilitate the comparisons across natural product families. Given their prevalence in pathogens prioritized by the World Health Organization, including Pseudomonas aeruginosa and Mycobacterium tuberculosis, YTMs represent promising targets for both ecological and therapeutic exploration.","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":" ","pages":""},"PeriodicalIF":10.6,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145190405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Engineering microbiomes for natural product discovery and production. 用于天然产物发现和生产的工程微生物组。

IF 10.6 1区化学

Natural Product Reports Pub Date : 2025-09-24 DOI: 10.1039/d5np00038f

Francesco Del Carratore, Rainer Breitling

{"title":"Engineering microbiomes for natural product discovery and production.","authors":"Francesco Del Carratore, Rainer Breitling","doi":"10.1039/d5np00038f","DOIUrl":"https://doi.org/10.1039/d5np00038f","url":null,"abstract":"Covering: 2021 to 2025Microbial communities represent a vast and largely untapped source of natural products with potential applications in various fields, including medicine, agriculture, and the biomanufacturing industry. Secondary metabolites play a crucial role in mediating interspecies interactions within these communities, influencing their structure and function. Recent advances in microbial genetic engineering and multi-omics technologies have enabled the harnessing of these interactions for enhanced natural product discovery and production. These techniques, coupled with systems biology and mathematical modelling, allow for the rational design and manipulation of microbial consortia to elicit the expression of cryptic biosynthetic gene clusters and to optimize the production of desired compounds. Additionally, direct mining of microbiomes using metagenomics, metatranscriptomics, and metabolomics has revealed a wealth of novel biosynthetic gene clusters and secondary metabolites with potential therapeutic and industrial value. Despite the challenges associated with cultivating and characterizing diverse microbial species, ongoing advancements in computational tools and data analysis are rapidly expanding our ability to explore and exploit the seemingly inexhaustible reservoir of natural products hidden within microbial communities.","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":" ","pages":""},"PeriodicalIF":10.6,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145129607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Scalability of mass spectrometry-based metabolomics for natural extracts libraries exploration: current status, challenges, and opportunities. 基于质谱的代谢组学在天然提取物文库探索中的可扩展性：现状、挑战和机遇。

IF 10.6 1区化学

Natural Product Reports Pub Date : 2025-09-15 DOI: 10.1039/d5np00034c

Adriano Rutz, Wout Bittremieux, Robin Schmid, Olivier Cailloux, Justin J J van der Hooft, Mehdi A Beniddir

引用次数: 0

Discovery, biosynthesis, and bioactivities of peptidic natural products from marine sponges and sponge-associated bacteria. 海洋海绵和海绵相关细菌多肽天然产物的发现、生物合成和生物活性。

IF 10.6 1区化学

Natural Product Reports Pub Date : 2025-09-12 DOI: 10.1039/d5np00048c

Weimao Zhong, Zhenjian Lin, Eric W Schmidt, Vinayak Agarwal

引用次数: 0

The oxidative rearrangements in bacterial aromatic polyketide biosynthesis. 细菌芳香族聚酮生物合成中的氧化重排。

IF 10.6 1区化学

Natural Product Reports Pub Date : 2025-09-10 DOI: 10.1039/d5np00049a

Fangwen Jiao, Shuai Li, Hongzhi Qiao, Ruihua Jiao

{"title":"The oxidative rearrangements in bacterial aromatic polyketide biosynthesis.","authors":"Fangwen Jiao, Shuai Li, Hongzhi Qiao, Ruihua Jiao","doi":"10.1039/d5np00049a","DOIUrl":"https://doi.org/10.1039/d5np00049a","url":null,"abstract":"Covering: up to April 2025Bacterial aromatic polyketides represent a notable class of natural products that have found extensive applications in clinical treatments. In their biosynthesis, oxidative rearrangements represent critical transformations that typically afford diverse scaffolds, structural rigidity, and biological activities. In this context, it is evident that redox enzymes are frequently implicated in various rearrangement processes, whereby they facilitate the transformation of pathway precursors into mature natural products. In this review, we will elucidate how natural enzymes utilize redox chemistry to create new carbon skeletons in the field of bacterial aromatic polyketide biosynthesis. Representative unique examples of Baeyer-Villiger and Favorskii-type oxidative rearrangements catalyzed by flavin-dependent monooxygenases, innovative carbon skeleton rearrangements catalyzed by ketoreductases and dioxygenases, as well as intermolecular dimerization catalyzed by CYP450s or NmrA-like proteins, are summarized and discussed. Concurrently, the structural characteristics and catalytic mechanisms of selected enzymes will also be introduced. By revealing the intriguing chemistry and enzymology behind these oxidative rearrangement transformations, this comprehensive review will not only enhance our comprehension of this uncommon chemical regularity but also provide potent biocatalysts for the semi-synthesis or synthetic biology of complex natural molecules.","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":" ","pages":""},"PeriodicalIF":10.6,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145028572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Natural product-derived compounds in clinical trials and drug approvals. 临床试验和药物批准中的天然产品衍生化合物。

IF 10.6 1区化学

Natural Product Reports Pub Date : 2025-09-09 DOI: 10.1039/d5np00031a

Mark S Butler, Robert J Capon, Mark A T Blaskovich, Ian R Henderson

{"title":"Natural product-derived compounds in clinical trials and drug approvals.","authors":"Mark S Butler, Robert J Capon, Mark A T Blaskovich, Ian R Henderson","doi":"10.1039/d5np00031a","DOIUrl":"https://doi.org/10.1039/d5np00031a","url":null,"abstract":"Covering: January 2014-June 2025. Previous review: Natural Product Reports, 2014, 31, 1612Natural products (NPs) have long been foundational in medicine, from ancient herbal remedies to the discovery of transformative drugs like morphine and quinine. The mid-20th century marked a 'golden age' for antibiotic discovery from natural sources, which then expanded into other therapeutic areas. However, by the late 20th century, other technological advances had shifted NPs from being a central component of the discovery process to one of several options. This review explores the current role of NPs in pharmaceuticals by analysing NP-derived (NP-D) drugs approved since 2014 and clinical candidates in development as of the end of 2024. 58 NP-related drugs launched between January 2014 and June 2025 were identified, which included 45 NP and NP-D new chemical entities (NCEs) and 13 NP-antibody drug conjugates (NP-ADCs). Next, all 579 drugs-388 (67%) of which were NCEs and 191 (33%) were new biological entities (NBEs)-approved globally from 2014 to 2024 were analysed. In total, 56 (9.7%) of these 579 drugs were classified as NPs or NP-Ds using this review's NP definition: 44 NCEs (7.6% overall; 11.3% of NCEs) and 12 NP-ADCs (2.1% overall; 6.3% of NBEs). The number of new NP-D NCEs and NP-ADCs has fluctuated between 0 and 8 annually since 2014, with an average of five approvals per year. Next, 125 NP and NP-D compounds were identified that were undergoing clinical trials or in the registration phase at the end of December 2024. Thirty-three new pharmacophores not previously found in approved drugs are now in development; however, only one has been discovered in the past 15 years. This review highlights the enduring promise of NPs, despite their diminished role in drug discovery, and advocates for renewed emphasis on bioassay-guided isolation and mode of action studies to identify new drug leads.","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":" ","pages":""},"PeriodicalIF":10.6,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145022490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rotenoid diversity, distribution and evolution in plant lineages. 植物谱系中类鱼藤的多样性、分布和进化。

IF 10.6 1区化学

Natural Product Reports Pub Date : 2025-09-09 DOI: 10.1039/d5np00054h

Vaderament-A Nchiozem-Ngnitedem, Alan Paton, Gabin Thierry M Bitchagno

{"title":"Rotenoid diversity, distribution and evolution in plant lineages.","authors":"Vaderament-A Nchiozem-Ngnitedem, Alan Paton, Gabin Thierry M Bitchagno","doi":"10.1039/d5np00054h","DOIUrl":"https://doi.org/10.1039/d5np00054h","url":null,"abstract":"Covering upto 2025Rotenoids are angular hybrid isoflavonoids mainly characterized by an additional six-membered ring between the B and C rings of flavonoids. The extra ring introduces further chemical diversity to the densely substituted precursors, isoflavonoids, making rotenoids a significant group of compounds within the plant kingdom. Early biosynthesis studies by L. Crombie, Nat. Prod. Rep., 1984, 1, 3-19, and subsequent revisions housed rotenoids into three groups, based on the oxygenation pattern of the bridge carbons between rings B and C. Since then, many more new structures of rotenoids have been discovered, prompting a need to revisit this classification as key structural traits of rotenoids might contribute to phylogenetic relationships and lineage diversification of plants. The new classification builds upon previous considerations, but also incorporates the defining feature of rotenoids, the additional carbon at the C-6 position, leading to nine distinct classes (Types I-IX). Types I and VII were found with the most representatives, predominantly distributed across the Pentapetalae clade, but also found in a few monocots. Rotenoids were found in phylogenetically distant lineages within the clade, raising intriguing questions about the evolutionary pathways that led to their biosynthesis and how their occurrences could inform plant taxonomy. The review addresses these questions and provides a thorough understanding of rotenoids and their chemotaxonomy significance.","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":" ","pages":""},"PeriodicalIF":10.6,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145022503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Streptomyces as a versatile host platform for heterologous production of microbial natural products. 链霉菌作为异源生产微生物天然产物的多功能宿主平台。

IF 10.6 1区化学

Natural Product Reports Pub Date : 2025-09-09 DOI: 10.1039/d5np00036j

Constanze Lasch, Maksym Myronovskyi, Andriy Luzhetskyy

{"title":"Streptomyces as a versatile host platform for heterologous production of microbial natural products.","authors":"Constanze Lasch, Maksym Myronovskyi, Andriy Luzhetskyy","doi":"10.1039/d5np00036j","DOIUrl":"https://doi.org/10.1039/d5np00036j","url":null,"abstract":"Focus on 2004 to 2024The rediscovery of natural products (NPs) as a critical source of new therapeutics has been greatly advanced by the development of heterologous expression platforms for biosynthetic gene clusters (BGCs). Among these, Streptomyces species have emerged as the most widely used and versatile chassis for expressing complex BGCs from diverse microbial origins. In this review, we provide a comprehensive analysis of over 450 peer-reviewed studies published between 2004 and 2024 that describe the heterologous expression of BGCs in Streptomyces hosts. We present a data-driven overview of expression trends across time, BGC types, donor species, and host strain preferences, offering the first quantitative perspective on how this field has evolved over two decades. Our review discusses the key factors influencing successful BGC expression in Streptomyces, including genomic integration strategies, regulatory elements, codon optimization, and precursor supply. We also examine the impact of synthetic biology tools, genome engineering, and host strain tailoring in overcoming common expression barriers. Special emphasis is placed on the role of heterologous expression in accessing silent or cryptic BGCs, elucidating biosynthetic pathways, and generating new-to-nature analogues through combinatorial biosynthesis. By integrating technological advances with practical case studies, we highlight how Streptomyces-based heterologous expression is enabling not only the efficient production of known compounds but also the discovery of structurally novel and biologically potent metabolites. This review aims to serve as a resource for researchers in natural products, synthetic biology, and drug discovery who seek to harness the full potential of microbial biosynthetic diversity.","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":" ","pages":""},"PeriodicalIF":10.6,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145022460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0