Natural Product Reports最新文献

Bi- and tricyclic diterpenoids: landmarks from a decade (2013-2023) in search of leads against infectious diseases. 双环和三环二萜类化合物：寻找抗传染病线索十年（2013-2023 年）的里程碑。

IF 10.2 1区化学

Natural Product Reports Pub Date : 2024-10-07 DOI: 10.1039/d4np00021h

Olha Antoniuk, Ana Maranha, Jorge A R Salvador, Nuno Empadinhas, Vânia M Moreira

引用次数: 0

Hot off the Press 新闻热点

IF 10.2 1区化学

Natural Product Reports Pub Date : 2024-10-04 DOI: 10.1039/D4NP90043J

Robert A. Hill and Andrew Sutherland

引用次数: 0

Structural diversity, evolutionary origin, and metabolic engineering of plant specialized benzylisoquinoline alkaloids. 植物特化苄基异喹啉生物碱的结构多样性、进化起源和代谢工程。

IF 10.2 1区化学

Natural Product Reports Pub Date : 2024-10-03 DOI: 10.1039/d4np00029c

Ya Tian, Lingzhe Kong, Qi Li, Yifan Wang, Yongmiao Wang, Zhoujie An, Yuwei Ma, Lixia Tian, Baozhong Duan, Wei Sun, Ranran Gao, Shilin Chen, Zhichao Xu

{"title":"Structural diversity, evolutionary origin, and metabolic engineering of plant specialized benzylisoquinoline alkaloids.","authors":"Ya Tian, Lingzhe Kong, Qi Li, Yifan Wang, Yongmiao Wang, Zhoujie An, Yuwei Ma, Lixia Tian, Baozhong Duan, Wei Sun, Ranran Gao, Shilin Chen, Zhichao Xu","doi":"10.1039/d4np00029c","DOIUrl":"https://doi.org/10.1039/d4np00029c","url":null,"abstract":"<p><p>Covering: up to June 2024Benzylisoquinoline alkaloids (BIAs) represent a diverse class of plant specialized metabolites derived from L-tyrosine, exhibiting significant pharmacological properties such as anti-microbial, anti-spasmodic, anti-cancer, cardiovascular protection, and analgesic effects. The industrial production of valuable BIAs relies on extraction from plants; however, challenges concerning their low concentration and efficiency hinder drug development. Hence, alternative approaches, including biosynthesis and chemoenzymatic synthesis, have been explored. Model species like <i>Papaver somniferum</i> and <i>Coptis japonica</i> have played a key role in unraveling the biosynthetic pathways of BIAs; however, many aspects, particularly modified steps like oxidation and methylation, remain unclear. Critical enzymes, <i>e.g.</i>, CYP450s and methyltransferases, play a substantial role in BIA backbone formation and modification, which is essential for understanding the origin and adaptive evolution of these plant specialized metabolites. This review comprehensively analyzes the structural diversity of reported BIAs and their distribution in plant lineages. In addition, the progress in understanding biosynthesis, evolution, and catalytic mechanisms underlying BIA biosynthesis is summarized. Finally, we discuss the progress and challenges in metabolic engineering, providing valuable insights into BIA drug development and the sustainable utilization of BIA-producing plants.</p>","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":null,"pages":null},"PeriodicalIF":10.2,"publicationDate":"2024-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142363530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Isolation, biological activity, and synthesis of isoquinoline alkaloids. 异喹啉生物碱的分离、生物活性和合成。

IF 10.2 1区化学

Natural Product Reports Pub Date : 2024-10-02 DOI: 10.1039/d4np00023d

Xiaorong Yang, Xiaolou Miao, Lixia Dai, Xiao Guo, Janar Jenis, Jiyu Zhang, Xiaofei Shang

{"title":"Isolation, biological activity, and synthesis of isoquinoline alkaloids.","authors":"Xiaorong Yang, Xiaolou Miao, Lixia Dai, Xiao Guo, Janar Jenis, Jiyu Zhang, Xiaofei Shang","doi":"10.1039/d4np00023d","DOIUrl":"https://doi.org/10.1039/d4np00023d","url":null,"abstract":"<p><p>Covering: 2019 to 2023Isoquinoline alkaloids, an important class of <i>N</i>-based heterocyclic compounds, have attracted considerable attention from researchers worldwide. To follow up on our prior review (covering 2014-2018) and present the progress of this class of compounds, this review summarizes and provides updated literature on novel isoquinoline alkaloids isolated during the period of 2019-2023, together with their biological activity and underlying mechanisms of action. Moreover, with the rapid development of synthetic modification strategies, the synthesis strategies of isoquinoline alkaloids have been continuously optimized, and the total synthesis of these classes of natural products is reviewed critically herein. Over 250 molecules with a broad range of bioactivities, including antitumor, antibacterial, cardioprotective, anti-inflammatory, neuroprotective and other activities, are isolated and discussed. The total synthesis of more than nine classes of isoquinoline alkaloids is presented, and thirteen compounds constitute the first total synthesis. This survey provides new indications or possibilities for the discovery of new drugs from the original naturally occurring isoquinoline alkaloids.</p>","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":null,"pages":null},"PeriodicalIF":10.2,"publicationDate":"2024-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142360793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring nature's battlefield: organismic interactions in the discovery of bioactive natural products. 探索大自然的战场：生物活性天然产品发现过程中的有机体相互作用。

IF 10.2 1区化学

Natural Product Reports Pub Date : 2024-09-24 DOI: 10.1039/d4np00018h

Yuyang Wang, Yan-Ni Shi, Hao Xiang, Yi-Ming Shi

{"title":"Exploring nature's battlefield: organismic interactions in the discovery of bioactive natural products.","authors":"Yuyang Wang, Yan-Ni Shi, Hao Xiang, Yi-Ming Shi","doi":"10.1039/d4np00018h","DOIUrl":"https://doi.org/10.1039/d4np00018h","url":null,"abstract":"<p><p>Covering: up to March 2024.Microbial natural products have historically been a cornerstone for the discovery of therapeutic agents. Advanced (meta)genome sequencing technologies have revealed that microbes harbor far greater biosynthetic capabilities than previously anticipated. However, despite the application of CRISPR/Cas-based gene editing and high-throughput technologies to activate silent biosynthetic gene clusters, the rapid identification of new natural products has not led to a proportional increase in the discovery rate of lead compounds or drugs. A crucial issue in this gap may be insufficient knowledge about the inherent biological and physiological functions of microbial natural products. Addressing this gap necessitates recognizing that the generation of functional natural products is deeply rooted in the interactions between the producing microbes and other (micro)organisms within their ecological contexts, an understanding that is essential for harnessing their potential therapeutic benefits. In this review, we highlight the discovery of functional microbial natural products from diverse niches, including those associated with humans, nematodes, insects, fungi, protozoa, plants, and marine animals. Many of these findings result from an organismic-interaction-guided strategy using multi-omic approaches. The current importance of this topic lies in its potential to advance drug discovery in an era marked by increasing antimicrobial resistance.</p>","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":null,"pages":null},"PeriodicalIF":10.2,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142337502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chemical case studies from natural products of recent interest in the crop protection industry 作物保护行业近期关注的天然产品化学案例研究

IF 11.9 1区化学

Natural Product Reports Pub Date : 2024-09-19 DOI: 10.1039/d4np00035h

Georg Späth, Olivier Loiseleur

引用次数: 0

Phytochemical and pharmacological properties of the genus Alpinia from 2016 to 2023 2016 年至 2023 年阿尔皮纳属的植物化学和药理特性。

IF 10.2 1区化学

Natural Product Reports Pub Date : 2024-09-18 DOI: 10.1039/d4np00004h

引用次数: 0

Terpenoids of plants from Chloranthaceae family: chemistry, bioactivity, and synthesis† 绿茶科植物的萜类化合物：化学、生物活性和合成。

IF 10.2 1区化学

Natural Product Reports Pub Date : 2024-09-18 DOI: 10.1039/d4np00005f

引用次数: 0

Unleashing the potential: type I CRISPR-Cas systems in actinomycetes for genome editing 释放潜能：放线菌中用于基因组编辑的 I 型 CRISPR-Cas 系统。

IF 10.2 1区化学

Natural Product Reports Pub Date : 2024-09-18 DOI: 10.1039/d4np00010b

{"title":"Unleashing the potential: type I CRISPR-Cas systems in actinomycetes for genome editing","authors":"","doi":"10.1039/d4np00010b","DOIUrl":"10.1039/d4np00010b","url":null,"abstract":"<div><div>Covering: up to the end of 2023</div></div><div><div>Type I CRISPR-Cas systems are widely distributed, found in over 40% of bacteria and 80% of archaea. Among genome-sequenced actinomycetes (particularly <em>Streptomyces</em> spp.), 45.54% possess type I CRISPR-Cas systems. In comparison to widely used CRISPR systems like Cas9 or Cas12a, these endogenous CRISPR-Cas systems have significant advantages, including better compatibility, wide distribution, and ease of operation (since no exogenous Cas gene delivery is needed). Furthermore, type I CRISPR-Cas systems can simultaneously edit and regulate genes by adjusting the crRNA spacer length. Meanwhile, most actinomycetes are recalcitrant to genetic manipulation, hindering the discovery and engineering of natural products (NPs). The endogenous type I CRISPR-Cas systems in actinomycetes may offer a promising alternative to overcome these barriers. This review summarizes the challenges and recent advances in CRISPR-based genome engineering technologies for actinomycetes. It also presents and discusses how to establish and develop genome editing tools based on type I CRISPR-Cas systems in actinomycetes, with the aim of their future application in gene editing and the discovery of NPs in actinomycetes.</div></div>","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":null,"pages":null},"PeriodicalIF":10.2,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141416726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Current and emerging tools and strategies for the identification of bioactive natural products in complex mixtures 鉴定复杂混合物中生物活性天然产品的现有和新兴工具与策略

IF 11.9 1区化学

Natural Product Reports Pub Date : 2024-09-18 DOI: 10.1039/d4np00006d

Manon Meunier, Andreas Schinkovitz, Séverine Derbré

引用次数: 0