Natural Product Reports最新文献

筛选
英文 中文
Correction: Biosynthesis, biological activities, and structure-activity relationships of decalin-containing tetramic acid derivatives isolated from fungi. 更正:从真菌中分离出的含蜕皮激素的四元酸衍生物的生物合成、生物活性和结构-活性关系。
IF 10.2 1区 化学
Natural Product Reports Pub Date : 2024-07-10 DOI: 10.1039/d4np90030h
Hyun Woo Kim, Jin Woo Lee, Sang Hee Shim
{"title":"Correction: Biosynthesis, biological activities, and structure-activity relationships of decalin-containing tetramic acid derivatives isolated from fungi.","authors":"Hyun Woo Kim, Jin Woo Lee, Sang Hee Shim","doi":"10.1039/d4np90030h","DOIUrl":"https://doi.org/10.1039/d4np90030h","url":null,"abstract":"<p><p>Correction for 'Biosynthesis, biological activities, and structure-activity relationships of decalin-containing tetramic acid derivatives isolated from fungi' by Hyun Woo Kim <i>et al.</i>, <i>Nat. Prod. Rep.</i>, 2024, https://doi.org/10.1039/d4np00013g.</p>","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":null,"pages":null},"PeriodicalIF":10.2,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141562015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The dichapetalins and dichapetalin-type compounds: structural diversity, bioactivity, and future research perspectives. 二氢杨梅素和二氢杨梅素类化合物:结构多样性、生物活性和未来研究前景。
IF 10.2 1区 化学
Natural Product Reports Pub Date : 2024-07-04 DOI: 10.1039/d3np00039g
Ivan Addae-Mensah, Godwin Akpeko Dziwornu, Mary Anti Chama, Dorcas Osei-Safo
{"title":"The dichapetalins and dichapetalin-type compounds: structural diversity, bioactivity, and future research perspectives.","authors":"Ivan Addae-Mensah, Godwin Akpeko Dziwornu, Mary Anti Chama, Dorcas Osei-Safo","doi":"10.1039/d3np00039g","DOIUrl":"https://doi.org/10.1039/d3np00039g","url":null,"abstract":"<p><p>Covering mainly from 2013 up to 2023 with relevant references to work done before 2013First reported in 1995, the dichapetalins and analogous compounds constitute a novel class of natural dammarane-type merotriterpenoids characterized by their unique 2-phenylpyrano moiety annellated to ring A of the dammarane skeleton. They have been reported from only two genera: <i>Dichapetalum</i> (Dichapetalaceae) and <i>Phyllanthus</i> (Phyllanthaceae). About 100 novel dichapetalins and dichapetalin-type compounds, including the acutissimatriterpenes and their antitumour and other bioactivities have been reported. In the present review, we cover the distribution, ethnobotanical and medicinal importance and the diversity of secondary metabolites reported from the two genera <i>Dichapetalum</i> and <i>Phyllanthus</i> from 2013 to date, with appropriate reference to relevant information prior to 2013. We also propose and discuss possible biosynthetic pathways, antitumour activity against a broad range of human and murine cancer cell lines, structure activity relationships, and other biological activities and mechanisms of action. Finally, the review deals with future perspectives which include expansion of the structural diversity and bioactivity scope, possible simplification of the structural complexity of the compounds to enhance their drug-likeness, <i>in silico</i> studies, and continuation of the search for new dichapetalins and dichapetalin-type compounds from the over 200 <i>Dichapetalum</i> and over 1200 <i>Phyllanthus</i> species yet to be investigated. It is envisaged that the present review will stimulate further multidisciplinary and interdisciplinary studies.</p>","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":null,"pages":null},"PeriodicalIF":10.2,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141496403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biosynthesis, biological activities, and structure-activity relationships of decalin-containing tetramic acid derivatives isolated from fungi. 从真菌中分离出的含蜕皮激素的四元酸衍生物的生物合成、生物活性和结构-活性关系。
IF 10.2 1区 化学
Natural Product Reports Pub Date : 2024-06-25 DOI: 10.1039/d4np00013g
Hyun Woo Kim, Jin Woo Lee, Sang Hee Shim
{"title":"Biosynthesis, biological activities, and structure-activity relationships of decalin-containing tetramic acid derivatives isolated from fungi.","authors":"Hyun Woo Kim, Jin Woo Lee, Sang Hee Shim","doi":"10.1039/d4np00013g","DOIUrl":"10.1039/d4np00013g","url":null,"abstract":"<p><p>Covering: up to December 2023Decalin-containing tetramic acid derivatives, especially 3-decalinoyltetramic acids (3-DTAs), are commonly found as fungal secondary metabolites. Numerous biological activities of this class of compounds, such as antibiotic, antiviral, antifungal, antiplasmodial, and antiprotozoal properties, have been the subject of ongoing research. For this reason, these molecules have attracted a lot of interest from the scientific community and various efforts including semi-synthesis, co-culturing with bacteria and biosynthetic gene sequencing have been made to obtain more derivatives. In this review, 3-DTAs are classified into four major groups based on the absolute configuration of the bicyclic decalin ring. Their biosynthetic pathways, various biological activities, and structure-activity relationship are then introduced.</p>","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":null,"pages":null},"PeriodicalIF":10.2,"publicationDate":"2024-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141445623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advances, opportunities, and challenges in methods for interrogating the structure activity relationships of natural products. 天然产品结构活性关系研究方法的进展、机遇和挑战。
IF 10.2 1区 化学
Natural Product Reports Pub Date : 2024-06-24 DOI: 10.1039/d4np00009a
Christine Mae F Ancajas, Abiodun S Oyedele, Caitlin M Butt, Allison S Walker
{"title":"Advances, opportunities, and challenges in methods for interrogating the structure activity relationships of natural products.","authors":"Christine Mae F Ancajas, Abiodun S Oyedele, Caitlin M Butt, Allison S Walker","doi":"10.1039/d4np00009a","DOIUrl":"https://doi.org/10.1039/d4np00009a","url":null,"abstract":"<p><p>Time span in literature: 1985-early 2024Natural products play a key role in drug discovery, both as a direct source of drugs and as a starting point for the development of synthetic compounds. Most natural products are not suitable to be used as drugs without further modification due to insufficient activity or poor pharmacokinetic properties. Choosing what modifications to make requires an understanding of the compound's structure-activity relationships. Use of structure-activity relationships is commonplace and essential in medicinal chemistry campaigns applied to human-designed synthetic compounds. Structure-activity relationships have also been used to improve the properties of natural products, but several challenges still limit these efforts. Here, we review methods for studying the structure-activity relationships of natural products and their limitations. Specifically, we will discuss how synthesis, including total synthesis, late-stage derivatization, chemoenzymatic synthetic pathways, and engineering and genome mining of biosynthetic pathways can be used to produce natural product analogs and discuss the challenges of each of these approaches. Finally, we will discuss computational methods including machine learning methods for analyzing the relationship between biosynthetic genes and product activity, computer aided drug design techniques, and interpretable artificial intelligence approaches towards elucidating structure-activity relationships from models trained to predict bioactivity from chemical structure. Our focus will be on these latter topics as their applications for natural products have not been extensively reviewed. We suggest that these methods are all complementary to each other, and that only collaborative efforts using a combination of these techniques will result in a full understanding of the structure-activity relationships of natural products.</p>","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":null,"pages":null},"PeriodicalIF":10.2,"publicationDate":"2024-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141441830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The insect microbiome is a vast source of bioactive small molecules† 昆虫微生物群是生物活性小分子的巨大来源。
IF 11.9 1区 化学
Natural Product Reports Pub Date : 2024-06-19 DOI: 10.1039/d3np00054k
Carlismari Oliveira Grundmann , Juan Guzman , Andreas Vilcinskas , Mônica Tallarico Pupo
{"title":"The insect microbiome is a vast source of bioactive small molecules†","authors":"Carlismari Oliveira Grundmann ,&nbsp;Juan Guzman ,&nbsp;Andreas Vilcinskas ,&nbsp;Mônica Tallarico Pupo","doi":"10.1039/d3np00054k","DOIUrl":"10.1039/d3np00054k","url":null,"abstract":"<div><p>Covering: September 1964 to June 2023</p></div><div><p>Bacteria and fungi living in symbiosis with insects have been studied over the last sixty years and found to be important sources of bioactive natural products. Not only classic producers of secondary metabolites such as <em>Streptomyces</em> and other members of the phylum Actinobacteria but also numerous bacteria from the phyla Proteobacteria and Firmicutes and an impressive array of fungi (usually pathogenic) serve as the source of a structurally diverse number of small molecules with important biological activities including antimicrobial, cytotoxic, antiparasitic and specific enzyme inhibitors. The insect niche is often the exclusive provider of microbes producing unique types of biologically active compounds such as gerumycins, pederin, dinactin, and formicamycins. However, numerous insects still have not been described taxonomically, and in most cases, the study of their microbiota is completely unexplored. In this review, we present a comprehensive survey of 553 natural products produced by microorganisms isolated from insects by collating and classifying all the data according to the type of compound (rather than the insect or microbial source). The analysis of the correlations among the metadata related to insects, microbial partners, and their produced compounds provides valuable insights into the intricate dynamics between insects and their symbionts as well as the impact of their metabolites on these relationships. Herein, we focus on the chemical structure, biosynthesis, and biological activities of the most relevant compounds.</p></div>","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":null,"pages":null},"PeriodicalIF":11.9,"publicationDate":"2024-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139970036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recent advances in discovery and biosynthesis of natural products from myxobacteria: an overview from 2017 to 2023 从霉菌中发现和生物合成天然产物的最新进展:2017 年至 2023 年概览。
IF 11.9 1区 化学
Natural Product Reports Pub Date : 2024-06-19 DOI: 10.1039/d3np00062a
Chao-Yi Wang , Jia-Qi Hu , De-Gao Wang , Yue-Zhong Li , Changsheng Wu
{"title":"Recent advances in discovery and biosynthesis of natural products from myxobacteria: an overview from 2017 to 2023","authors":"Chao-Yi Wang ,&nbsp;Jia-Qi Hu ,&nbsp;De-Gao Wang ,&nbsp;Yue-Zhong Li ,&nbsp;Changsheng Wu","doi":"10.1039/d3np00062a","DOIUrl":"10.1039/d3np00062a","url":null,"abstract":"<div><p>Covering: 2017.01 to 2023.11</p></div><div><p>Natural products biosynthesized by myxobacteria are appealing due to their sophisticated chemical skeletons, remarkable biological activities, and intriguing biosynthetic enzymology. This review aims to systematically summarize the advances in the discovery methods, new structures, and bioactivities of myxobacterial NPs reported in the period of 2017–2023. In addition, the peculiar biosynthetic pathways of several structural families are also highlighted.</p></div>","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":null,"pages":null},"PeriodicalIF":11.9,"publicationDate":"2024-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139928963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Connecting metabolome and phenotype: recent advances in functional metabolomics tools for the identification of bioactive natural products 连接代谢组和表型:用于鉴定生物活性天然产物的功能代谢组学工具的最新进展。
IF 11.9 1区 化学
Natural Product Reports Pub Date : 2024-06-19 DOI: 10.1039/d3np00050h
Giovanni Andrea Vitale , Christian Geibel , Vidit Minda , Mingxun Wang , Allegra T. Aron , Daniel Petras
{"title":"Connecting metabolome and phenotype: recent advances in functional metabolomics tools for the identification of bioactive natural products","authors":"Giovanni Andrea Vitale ,&nbsp;Christian Geibel ,&nbsp;Vidit Minda ,&nbsp;Mingxun Wang ,&nbsp;Allegra T. Aron ,&nbsp;Daniel Petras","doi":"10.1039/d3np00050h","DOIUrl":"10.1039/d3np00050h","url":null,"abstract":"<div><p>Covering: 1995 to 2023</p></div><div><p>Advances in bioanalytical methods, particularly mass spectrometry, have provided valuable molecular insights into the mechanisms of life. Non-targeted metabolomics aims to detect and (relatively) quantify all observable small molecules present in a biological system. By comparing small molecule abundances between different conditions or timepoints in a biological system, researchers can generate new hypotheses and begin to understand causes of observed phenotypes. Functional metabolomics aims to investigate the functional roles of metabolites at the scale of the metabolome. However, most functional metabolomics studies rely on indirect measurements and correlation analyses, which leads to ambiguity in the precise definition of functional metabolomics. In contrast, the field of natural products has a history of identifying the structures and bioactivities of primary and specialized metabolites. Here, we propose to expand and reframe functional metabolomics by integrating concepts from the fields of natural products and chemical biology. We highlight emerging functional metabolomics approaches that shift the focus from correlation to physical interactions, and we discuss how this allows researchers to uncover causal relationships between molecules and phenotypes.</p></div>","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":null,"pages":null},"PeriodicalIF":11.9,"publicationDate":"2024-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139728489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Purine nucleoside antibiotics: recent synthetic advances harnessing chemistry and biology 嘌呤核苷抗生素:利用化学和生物学的最新合成进展。
IF 11.9 1区 化学
Natural Product Reports Pub Date : 2024-06-19 DOI: 10.1039/d3np00051f
Jonas Motter , Caecilie M. M. Benckendorff , Sarah Westarp , Peter Sunde-Brown , Peter Neubauer , Anke Kurreck , Gavin J. Miller
{"title":"Purine nucleoside antibiotics: recent synthetic advances harnessing chemistry and biology","authors":"Jonas Motter ,&nbsp;Caecilie M. M. Benckendorff ,&nbsp;Sarah Westarp ,&nbsp;Peter Sunde-Brown ,&nbsp;Peter Neubauer ,&nbsp;Anke Kurreck ,&nbsp;Gavin J. Miller","doi":"10.1039/d3np00051f","DOIUrl":"10.1039/d3np00051f","url":null,"abstract":"<div><p>Covering: 2019 to 2023</p></div><div><p>Nucleoside analogues represent one of the most important classes of small molecule pharmaceuticals and their therapeutic development is successfully established within oncology and for the treatment of viral infections. However, there are currently no nucleoside analogues in clinical use for the management of bacterial infections. Despite this, a significant number of clinically recognised nucleoside analogues are known to possess some antibiotic activity, thereby establishing a potential source for new therapeutic discovery in this area. Furthermore, given the rise in antibiotic resistance, the discovery of new clinical candidates remains an urgent global priority and natural product-derived nucleoside analogues may also present a rich source of discovery space for new modalities. This Highlight, covering work published from 2019 to 2023, presents a current perspective surrounding the synthesis of natural purine nucleoside antibiotics. By amalgamating recent efforts from synthetic chemistry with advances in biosynthetic understanding and the use of recombinant enzymes, prospects towards different structural classes of purines are detailed.</p></div>","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":null,"pages":null},"PeriodicalIF":11.9,"publicationDate":"2024-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139400948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hot off the Press 新闻热点
IF 11.9 1区 化学
Natural Product Reports Pub Date : 2024-06-19 DOI: 10.1039/d4np90026j
Robert A. Hill , Andrew Sutherland
{"title":"Hot off the Press","authors":"Robert A. Hill ,&nbsp;Andrew Sutherland","doi":"10.1039/d4np90026j","DOIUrl":"10.1039/d4np90026j","url":null,"abstract":"<div><p>A personal selection of 32 recent papers is presented covering various aspects of current developments in bioorganic chemistry and novel natural products, such as penihemeroterpenoid A from <em>Penicillium herquei</em>.</p></div>","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":null,"pages":null},"PeriodicalIF":11.9,"publicationDate":"2024-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141178289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unleashing the potential: type I CRISPR-Cas systems in actinomycetes for genome editing. 释放潜能:放线菌中用于基因组编辑的 I 型 CRISPR-Cas 系统。
IF 11.9 1区 化学
Natural Product Reports Pub Date : 2024-06-18 DOI: 10.1039/d4np00010b
Shuliu Wang, Xiaoqian Zeng, Yue Jiang, Weishan Wang, Linquan Bai, Yinhua Lu, Lixin Zhang, Gao-Yi Tan
{"title":"Unleashing the potential: type I CRISPR-Cas systems in actinomycetes for genome editing.","authors":"Shuliu Wang, Xiaoqian Zeng, Yue Jiang, Weishan Wang, Linquan Bai, Yinhua Lu, Lixin Zhang, Gao-Yi Tan","doi":"10.1039/d4np00010b","DOIUrl":"https://doi.org/10.1039/d4np00010b","url":null,"abstract":"<p><p>Covering: up to the end of 2023Type I CRISPR-Cas systems are widely distributed, found in over 40% of bacteria and 80% of archaea. Among genome-sequenced actinomycetes (particularly <i>Streptomyces</i> spp.), 45.54% possess type I CRISPR-Cas systems. In comparison to widely used CRISPR systems like Cas9 or Cas12a, these endogenous CRISPR-Cas systems have significant advantages, including better compatibility, wide distribution, and ease of operation (since no exogenous Cas gene delivery is needed). Furthermore, type I CRISPR-Cas systems can simultaneously edit and regulate genes by adjusting the crRNA spacer length. Meanwhile, most actinomycetes are recalcitrant to genetic manipulation, hindering the discovery and engineering of natural products (NPs). The endogenous type I CRISPR-Cas systems in actinomycetes may offer a promising alternative to overcome these barriers. This review summarizes the challenges and recent advances in CRISPR-based genome engineering technologies for actinomycetes. It also presents and discusses how to establish and develop genome editing tools based on type I CRISPR-Cas systems in actinomycetes, with the aim of their future application in gene editing and the discovery of NPs in actinomycetes.</p>","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":null,"pages":null},"PeriodicalIF":11.9,"publicationDate":"2024-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141416726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信