Natural Product Reports最新文献

IF 10.2 1区化学

Natural Product Reports Pub Date : 2025-04-09 DOI: 10.1039/D5NP90012C

引用次数: 0

Molecular insights fast-tracked: AI in biosynthetic pathway research.

IF 10.2 1区化学

Natural Product Reports Pub Date : 2025-03-25 DOI: 10.1039/d4np00003j

Lijuan Liao, Mengjun Xie, Xiaoshan Zheng, Zhao Zhou, Zixin Deng, Jiangtao Gao

{"title":"Molecular insights fast-tracked: AI in biosynthetic pathway research.","authors":"Lijuan Liao, Mengjun Xie, Xiaoshan Zheng, Zhao Zhou, Zixin Deng, Jiangtao Gao","doi":"10.1039/d4np00003j","DOIUrl":"https://doi.org/10.1039/d4np00003j","url":null,"abstract":"Covering: 2000 to 2025This review explores the potential of artificial intelligence (AI) in addressing challenges and accelerating molecular insights in biosynthetic pathway research, which is crucial for developing bioactive natural products with applications in pharmacology, agriculture, and biotechnology. It provides an overview of various AI techniques relevant to this research field, including machine learning (ML), deep learning (DL), natural language processing, network analysis, and data mining. AI-powered applications across three main areas, namely, pathway discovery and mining, pathway design, and pathway optimization, are discussed, and the benefits and challenges of integrating omics data and AI for enhanced pathway research are also elucidated. This review also addresses the current limitations, future directions, and the importance of synergy between AI and experimental approaches in unlocking rapid advancements in biosynthetic pathway research. The review concludes with an evaluation of AI's current capabilities and future outlook, emphasizing the transformative impact of AI on biosynthetic pathway research and the potential for new opportunities in the discovery and optimization of bioactive natural products.","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":" ","pages":""},"PeriodicalIF":10.2,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143699074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent advances in the application of the isoxazoline route to aldols in the synthesis of natural products.

IF 10.2 1区化学

Natural Product Reports Pub Date : 2025-03-20 DOI: 10.1039/d4np00069b

Pavel Yu Ushakov, Alexey Yu Sukhorukov

引用次数: 0

Privileged natural product compound classes for anti-inflammatory drug development.

IF 10.2 1区化学

Natural Product Reports Pub Date : 2025-03-11 DOI: 10.1039/d4np00066h

Malcolm Z Y Choo, Julian A T Chua, Sean X Y Lee, Yuet Ang, W S Fred Wong, Christina L L Chai

{"title":"Privileged natural product compound classes for anti-inflammatory drug development.","authors":"Malcolm Z Y Choo, Julian A T Chua, Sean X Y Lee, Yuet Ang, W S Fred Wong, Christina L L Chai","doi":"10.1039/d4np00066h","DOIUrl":"https://doi.org/10.1039/d4np00066h","url":null,"abstract":"Covering: up to early 2025Privileged compound classes of anti-inflammatory natural products are those where there are many reported members that possess anti-inflammatory properties. The identification of these classes is of particular relevance to drug discovery, as they could serve as valuable starting points in developing effective and safe anti-inflammatory agents. The privileged compound classes of natural products include the polyphenols, coumarins, labdane diterpenoids, sesquiterpene lactones, isoquinoline and indole alkaloids, each offering a variety of molecular scaffolds and functional groups that enable diverse interactions with biological targets. From a medicinal chemistry point of view, natural products are both a boon and a bane. The multi-targeting nature of natural products is a boon in the treatment of multi-factorial diseases such as inflammation, but promiscuity, poor potency and pharmacokinetic properties are significant hurdles that must be addressed to ensure these compounds can be effectively used as therapeutics. In addition, there are continued controversies regarding the efficacies of some of these natural products that will continue to polarise their use. In this review, examples of natural products of six privileged compound classes will be discussed for their potential use and possible further development as anti-inflammatory drugs.","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":" ","pages":""},"PeriodicalIF":10.2,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143595763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Illuminating the dark space of bioactive peptides with mass spectrometry.

IF 10.2 1区化学

Natural Product Reports Pub Date : 2025-03-11 DOI: 10.1039/d4np00057a

Nicole C Parsley, Leslie M Hicks

引用次数: 0

Intramolecular cycloaddition of nitrones in total synthesis of natural products.

IF 10.2 1区化学

Natural Product Reports Pub Date : 2025-03-10 DOI: 10.1039/d4np00062e

Satoshi Yokoshima

引用次数: 0

Enzymatic crosslinking of histidine side chains in peptide natural products.

IF 10.2 1区化学

Natural Product Reports Pub Date : 2025-03-03 DOI: 10.1039/d5np00001g

Ying Shi, Yinzheng Xia, Weijiang Gao, Jingxue Wang, Bing Shi, Huan Wang

引用次数: 0

Microbial dynamics and Pseudomonas natural product production in milk and dairy products.

IF 10.2 1区化学

Natural Product Reports Pub Date : 2025-03-03 DOI: 10.1039/d4np00074a

Ina Wasmuth, Christina Warinner, Pierre Stallforth

{"title":"Microbial dynamics and Pseudomonas natural product production in milk and dairy products.","authors":"Ina Wasmuth, Christina Warinner, Pierre Stallforth","doi":"10.1039/d4np00074a","DOIUrl":"10.1039/d4np00074a","url":null,"abstract":"Covering: 2000 up to the first half of 2024Milk and its derived dairy products have long been integral to the human diet, with evidence of consumption dating back over 9000 years. Milk's high nutritional value renders dairy products an important element of human diet while also offering a fertile environment for microbial growth. Beneficial microorganisms in dairy products are often associated with biogenic and probiotic effects, whereas spoilage or pathogenic microorganisms can pose health risks. Fermentation is a key method to preserve milk. Whereas dairying practices in most parts of the world have been highly altered by industrialization over the past century, nomadic pastoralists in Mongolia notably retain a rich tradition of household-level dairy fermentation that has been practiced since 3000 BC. Milk-associated microorganisms produce a vast number of low molecular weight natural products that can mediate beneficial and detrimental interactions. Bacteria of the genus Pseudomonas are found in traditional Mongolian dairy products and are common contaminants in commercial dairy products, and they can strongly impact the quality and shelf-life of dairy products. These bacteria are well known for their ability to produce a variety of secondary metabolites, including nonribosomal (lipo)peptides, which are both structurally and functionally diverse. Lipopeptides can have antimicrobial properties, act as quorum sensing molecules, and contribute to biofilm formation due to their amphiphilic nature. Although often associated with spoilage, some of these natural products can also exhibit positive effects with potential beneficial applications in the dairy industry. This review aims to provide a comprehensive overview of the interplay between culinary fermentation and the production and activities of microbial-derived natural products.","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":" ","pages":""},"PeriodicalIF":10.2,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11874467/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143539556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

'Need for speed: high throughput' - mass spectrometry approaches for high-throughput directed evolution screening of natural product enzymes.

IF 10.2 1区化学

Natural Product Reports Pub Date : 2025-02-27 DOI: 10.1039/d4np00053f

Robert A Shepherd, Conrad A Fihn, Alex J Tabag, Shaun M K McKinnie, Laura M Sanchez

引用次数: 0

Antarctic bacterial natural products: from genomic insights to drug discovery.

IF 10.2 1区化学

Natural Product Reports Pub Date : 2025-02-25 DOI: 10.1039/d4np00045e

William Medeiros, Stanislava Kralova, Valéria Oliveira, Nadine Ziemert, Ludek Sehnal

{"title":"Antarctic bacterial natural products: from genomic insights to drug discovery.","authors":"William Medeiros, Stanislava Kralova, Valéria Oliveira, Nadine Ziemert, Ludek Sehnal","doi":"10.1039/d4np00045e","DOIUrl":"https://doi.org/10.1039/d4np00045e","url":null,"abstract":"Covering: up to the end of 2024Microbial life dominates the extreme continent Antarctica, playing a pivotal role in ecosystem functioning and serving as a reservoir of specialized metabolites known as natural products (NPs). NPs not only contribute to microbial adaptation to harsh conditions but also modulate microbial community structure. Long-term isolation and environmental pressures have shaped the genomes of Antarctic bacteria, suggesting that they also encode unique NPs. Since NPs are also an important source of drugs, we argue that investigating Antarctic bacterial NPs is essential not only for understanding their ecological role and evolution, but also for discovering new chemical structures, biosynthetic mechanisms, and potential new drugs. Yet, despite advances in omics technologies and increased scientific activities in Antarctica, relatively few new bacterial NPs have been discovered. The lack of systematic research activities focused on the exploration of Antarctic bacteria and their NPs constitutes a big problem considering the climate change issue, to which ecosystems in polar regions are the most sensitive areas on the Earth. Here, we highlight the currently available data on Antarctic bacteria, their biosynthetic potential, and the successful NP discoveries, while addressing the challenges in NP research and advocating for systematic, collaborative efforts aligned with the Antarctic Treaty System and the Antarctic Conservation Biogeographic Regions.","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":" ","pages":""},"PeriodicalIF":10.2,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143490174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0