Natural Product Reports最新文献_第10页

Exploring nature's battlefield: organismic interactions in the discovery of bioactive natural products 探索大自然的战场：生物活性天然产品发现过程中的有机体相互作用。

IF 10.2 1区化学

Natural Product Reports Pub Date : 2024-09-18 DOI: 10.1039/d4np00018h

Yuyang Wang , Yan-Ni Shi , Hao Xiang , Yi-Ming Shi

{"title":"Exploring nature's battlefield: organismic interactions in the discovery of bioactive natural products","authors":"Yuyang Wang , Yan-Ni Shi , Hao Xiang , Yi-Ming Shi","doi":"10.1039/d4np00018h","DOIUrl":"10.1039/d4np00018h","url":null,"abstract":"<div><div>Covering: up to March 2024.</div></div><div><div>Microbial natural products have historically been a cornerstone for the discovery of therapeutic agents. Advanced (meta)genome sequencing technologies have revealed that microbes harbor far greater biosynthetic capabilities than previously anticipated. However, despite the application of CRISPR/Cas-based gene editing and high-throughput technologies to activate silent biosynthetic gene clusters, the rapid identification of new natural products has not led to a proportional increase in the discovery rate of lead compounds or drugs. A crucial issue in this gap may be insufficient knowledge about the inherent biological and physiological functions of microbial natural products. Addressing this gap necessitates recognizing that the generation of functional natural products is deeply rooted in the interactions between the producing microbes and other (micro)organisms within their ecological contexts, an understanding that is essential for harnessing their potential therapeutic benefits. In this review, we highlight the discovery of functional microbial natural products from diverse niches, including those associated with humans, nematodes, insects, fungi, protozoa, plants, and marine animals. Many of these findings result from an organismic-interaction-guided strategy using multi-omic approaches. The current importance of this topic lies in its potential to advance drug discovery in an era marked by increasing antimicrobial resistance.</div></div>","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":"41 11","pages":"Pages 1630-1651"},"PeriodicalIF":10.2,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2024/np/d4np00018h?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142337502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chemical synthesis and functional evaluation of glycopeptides and glycoproteins containing rare glycosyl amino acid linkages 含有稀有糖基氨基酸连接的糖肽和糖蛋白的化学合成和功能评估。

IF 10.2 1区化学

Natural Product Reports Pub Date : 2024-09-18 DOI: 10.1039/d4np00017j

{"title":"Chemical synthesis and functional evaluation of glycopeptides and glycoproteins containing rare glycosyl amino acid linkages","authors":"","doi":"10.1039/d4np00017j","DOIUrl":"10.1039/d4np00017j","url":null,"abstract":"<div><div>Covering: 1987 to 2023</div></div><div><div>Naturally existing glycoproteins through post-translational protein glycosylation are highly heterogeneous, which not only impedes the structure–function studies, but also hinders the development of their potential medical usage. Chemical synthesis represents one of the most powerful tools to provide the structurally well-defined glycoforms. Being the key step of glycoprotein synthesis, glycosylation usually takes place at serine, threonine, and asparagine residues, leading to the predominant formation of the <em>O</em>- and <em>N</em>-glycans, respectively. However, other amino acid residues containing oxygen, nitrogen, sulfur, and nucleophilic carbon atoms have also been found to be glycosylated. These diverse glycoprotein linkages, occurring from microorganisms to plants and animals, play also pivotal biological roles, such as in cell–cell recognition and communication. The availability of these homogenous rare glycopeptides and glycoproteins can help decipher the glyco-code for developing therapeutic agents. This review highlights the chemical approaches for assembly of the functional glycopeptides and glycoproteins bearing these “rare” carbohydrate–amino acid linkages between saccharide and canonical amino acid residues and their derivatives.</div></div>","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":"41 9","pages":"Pages 1403-1440"},"PeriodicalIF":10.2,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141416725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Isolation, biological activity, and synthesis of isoquinoline alkaloids† 异喹啉生物碱的分离、生物活性和合成。

IF 10.2 1区化学

Natural Product Reports Pub Date : 2024-09-18 DOI: 10.1039/d4np00023d

Xiaorong Yang , Xiaolou Miao , Lixia Dai , Xiao Guo , Janar Jenis , Jiyu Zhang , Xiaofei Shang

{"title":"Isolation, biological activity, and synthesis of isoquinoline alkaloids†","authors":"Xiaorong Yang , Xiaolou Miao , Lixia Dai , Xiao Guo , Janar Jenis , Jiyu Zhang , Xiaofei Shang","doi":"10.1039/d4np00023d","DOIUrl":"10.1039/d4np00023d","url":null,"abstract":"<div><div>Covering: 2019 to 2023</div></div><div><div>Isoquinoline alkaloids, an important class of <em>N</em>-based heterocyclic compounds, have attracted considerable attention from researchers worldwide. To follow up on our prior review (covering 2014–2018) and present the progress of this class of compounds, this review summarizes and provides updated literature on novel isoquinoline alkaloids isolated during the period of 2019–2023, together with their biological activity and underlying mechanisms of action. Moreover, with the rapid development of synthetic modification strategies, the synthesis strategies of isoquinoline alkaloids have been continuously optimized, and the total synthesis of these classes of natural products is reviewed critically herein. Over 250 molecules with a broad range of bioactivities, including antitumor, antibacterial, cardioprotective, anti-inflammatory, neuroprotective and other activities, are isolated and discussed. The total synthesis of more than nine classes of isoquinoline alkaloids is presented, and thirteen compounds constitute the first total synthesis. This survey provides new indications or possibilities for the discovery of new drugs from the original naturally occurring isoquinoline alkaloids.</div></div>","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":"41 11","pages":"Pages 1652-1722"},"PeriodicalIF":10.2,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2024/np/d4np00023d?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142360793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Retraction: Recent advances in total synthesis of protoberberine and chiral tetrahydroberberine alkaloids 撤回：原小檗碱和手性四氢小檗碱全合成的最新进展。

IF 10.2 1区化学

Natural Product Reports Pub Date : 2024-08-16 DOI: 10.1039/D4NP90039A

Zhen-Xi Niu, Ya-Tao Wang and Jun-Feng Wang

引用次数: 0

Biosynthesis, biological activities, and structure–activity relationships of decalin-containing tetramic acid derivatives isolated from fungi 从真菌中分离出的含蜕皮激素的四元酸衍生物的生物合成、生物活性和结构-活性关系。

IF 10.2 1区化学

Natural Product Reports Pub Date : 2024-08-14 DOI: 10.1039/d4np00013g

引用次数: 0

Hot off the press 热销中

IF 10.2 1区化学

Natural Product Reports Pub Date : 2024-08-14 DOI: 10.1039/d4np90034k

Robert A. Hill , Andrew Sutherland

引用次数: 0

Architecture of full-length type I modular polyketide synthases revealed by X-ray crystallography, cryo-electron microscopy, and AlphaFold2 通过 X 射线晶体学、冷冻电镜和 AlphaFold2 揭示全长 I 型模块化多酮合成酶的结构。

IF 10.2 1区化学

Natural Product Reports Pub Date : 2024-08-14 DOI: 10.1039/d3np00060e

引用次数: 0

Medium-sized peptides from microbial sources with potential for antibacterial drug development† 具有抗菌药物开发潜力的微生物来源中型肽。

IF 10.2 1区化学

Natural Product Reports Pub Date : 2024-08-14 DOI: 10.1039/d4np00002a

{"title":"Medium-sized peptides from microbial sources with potential for antibacterial drug development†","authors":"","doi":"10.1039/d4np00002a","DOIUrl":"10.1039/d4np00002a","url":null,"abstract":"<div><p>Covering: 1993 to the end of 2022</p></div><div><p>As the rapid development of antibiotic resistance shrinks the number of clinically available antibiotics, there is an urgent need for novel options to fill the existing antibiotic pipeline. In recent years, antimicrobial peptides have attracted increased interest due to their impressive broad-spectrum antimicrobial activity and low probability of antibiotic resistance. However, macromolecular antimicrobial peptides of plant and animal origin face obstacles in antibiotic development because of their extremely short elimination half-life and poor chemical stability. Herein, we focus on medium-sized antibacterial peptides (MAPs) of microbial origin with molecular weights below 2000 Da. The low molecular weight is not sufficient to form complex protein conformations and is also associated to a better chemical stability and easier modifications. Microbially-produced peptides are often composed of a variety of non-protein amino acids and terminal modifications, which contribute to improving the elimination half-life of compounds. Therefore, MAPs have great potential for drug discovery and are likely to become key players in the development of next-generation antibiotics. In this review, we provide a detailed exploration of the modes of action demonstrated by 45 MAPs and offer a concise summary of the structure–activity relationships observed in these MAPs.</p></div>","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":"41 8","pages":"Pages 1235-1263"},"PeriodicalIF":10.2,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140670631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances in the total synthesis of bis- and tris-indole alkaloids containing N-heterocyclic linker moieties 含有 N-杂环连接分子的双吲哚和三吲哚生物碱的全合成进展。

IF 10.2 1区化学

Natural Product Reports Pub Date : 2024-08-14 DOI: 10.1039/d4np00012a

引用次数: 0

Correction: The ‘emodin family’ of fungal natural products–amalgamating a century of research with recent genomics-based advances 更正：真菌天然产物 "大黄素家族"--百年研究与最新基因组学进展的结合。

IF 10.2 1区化学

Natural Product Reports Pub Date : 2024-08-09 DOI: 10.1039/D4NP90035A

Kate M. J. de Mattos-Shipley and Thomas J. Simpson

引用次数: 0