Natural Product Reports最新文献_第9页

Natural products with 1,2-oxazine scaffold: occurrence, chemical diversity, bioactivity, synthesis, and biosynthesis 具有 1,2-恶嗪支架的天然产品：出现、化学多样性、生物活性、合成和生物合成

IF 11.9 1区化学

Natural Product Reports Pub Date : 2023-08-29 DOI: 10.1039/D3NP00023K

Li-Hong Yan, Xin Li and Bin-Gui Wang

引用次数: 0

The role of Caenorhabditis elegans in the discovery of natural products for healthy aging† 草履虫在发现促进健康老龄化的天然产品中的作用†。

IF 11.9 1区化学

Natural Product Reports Pub Date : 2023-08-16 DOI: 10.1039/D3NP00021D

Benjamin Kirchweger, Julia Zwirchmayr, Ulrike Grienke and Judith M. Rollinger

{"title":"The role of Caenorhabditis elegans in the discovery of natural products for healthy aging†","authors":"Benjamin Kirchweger, Julia Zwirchmayr, Ulrike Grienke and Judith M. Rollinger","doi":"10.1039/D3NP00021D","DOIUrl":"10.1039/D3NP00021D","url":null,"abstract":"Covering: 2012 to 2023The human population is aging. Thus, the greatest risk factor for numerous diseases, such as diabetes, cancer and neurodegenerative disorders, is increasing worldwide. Age-related diseases do not typically occur in isolation, but as a result of multi-factorial causes, which in turn require holistic approaches to identify and decipher the mode of action of potential remedies. With the advent of C. elegans as the primary model organism for aging, researchers now have a powerful in vivo tool for identifying and studying agents that effect lifespan and health span. Natural products have been focal research subjects in this respect. This review article covers key developments of the last decade (2012–2023) that have led to the discovery of natural products with healthy aging properties in C. elegans. We (i) discuss the state of knowledge on the effects of natural products on worm aging including methods, assays and involved pathways; (ii) analyze the literature on natural compounds in terms of their molecular properties and the translatability of effects on mammals; (iii) examine the literature on multi-component mixtures with special attention to the studied organisms, extraction methods and efforts regarding the characterization of their chemical composition and their bioactive components. (iv) We further propose to combine small in vivo model organisms such as C. elegans and sophisticated analytical approaches (“wormomics”) to guide the way to dissect complex natural products with anti-aging properties.","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":null,"pages":null},"PeriodicalIF":11.9,"publicationDate":"2023-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2023/np/d3np00021d?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10014017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Structural enzymology of iterative type I polyketide synthases: various routes to catalytic programming 迭代I型聚酮合成酶的结构酶学:催化编程的各种途径

IF 11.9 1区化学

Natural Product Reports Pub Date : 2023-08-15 DOI: 10.1039/D3NP00015J

Jialiang Wang, Zixin Deng, Jingdan Liang and Zhijun Wang

引用次数: 0

Engineering yeast for the production of plant terpenoids using synthetic biology approaches† 利用合成生物学方法改造酵母生产植物萜类化合物†。

IF 11.9 1区化学

Natural Product Reports Pub Date : 2023-07-31 DOI: 10.1039/D3NP00005B

Jean-Alexandre Bureau, Magdalena Escobar Oliva, Yueming Dong and Codruta Ignea

引用次数: 1

Hot off the press 刚印出来的

IF 11.9 1区化学

Natural Product Reports Pub Date : 2023-07-28 DOI: 10.1039/D3NP90037A

Robert A. Hill and Andrew Sutherland

引用次数: 0

Anthrol reductases: discovery, role in biosynthesis and applications in natural product syntheses† 蒽还原酶：发现、在生物合成中的作用和在天然产物合成中的应用。

IF 11.9 1区化学

Natural Product Reports Pub Date : 2023-07-21 DOI: 10.1039/D3NP00027C

Anshul Rajput, Tanaya Manna and Syed Masood Husain

{"title":"Anthrol reductases: discovery, role in biosynthesis and applications in natural product syntheses†","authors":"Anshul Rajput, Tanaya Manna and Syed Masood Husain","doi":"10.1039/D3NP00027C","DOIUrl":"10.1039/D3NP00027C","url":null,"abstract":"Covering: up to 2023Short-chain dehydrogenase/reductases (SDR) are known to catalyze the regio- and stereoselective reduction of a variety of substrate types. Investigations of the deoxygenation of emodin to chrysophanol has led to the discovery of the anthrol reductase activity of an SDR, MdpC involved in monodictyphenone biosynthesis of Aspergillus nidulans and provided access to (R)-dihydroanthracenone, a putative biosynthetic intermediate. This facilitated the identification of several MdpC-related enzymes involved in the biosynthesis of aflatoxins B1, cladofulvin, neosartorin, agnestins and bisanthraquinones. Because of their ability to catalyze the reduction of hydroanthraquinone (anthrols) using NADPH, they were named anthrol reductases. This review provides a comprehensive summary of all the anthrol reductases that have been identified and characterized in the last decade along with their role in the biosynthesis of natural products. In addition, the applications of these enzymes towards the chemoenzymatic synthesis of flavoskyrins, modified bisanthraquinones, 3-deoxy anthraquinones, chiral cycloketones and β-halohydrins have been discussed.","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":null,"pages":null},"PeriodicalIF":11.9,"publicationDate":"2023-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9847175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Scalemic natural products 鳞片状天然产物。

IF 11.9 1区化学

Natural Product Reports Pub Date : 2023-07-13 DOI: 10.1039/D3NP00014A

Sarah Mazzotta, Vincenzo Rositano, Luca Senaldi, Anna Bernardi, Pietro Allegrini and Giovanni Appendino

引用次数: 0

Natural products acting against S. aureus through membrane and cell wall disruption 通过膜和细胞壁破坏对抗金黄色葡萄球菌的天然产物

IF 11.9 1区化学

Natural Product Reports Pub Date : 2023-06-16 DOI: 10.1039/D2NP00084A

Gautam Kumar and Kritika Engle

{"title":"Natural products acting against S. aureus through membrane and cell wall disruption","authors":"Gautam Kumar and Kritika Engle","doi":"10.1039/D2NP00084A","DOIUrl":"https://doi.org/10.1039/D2NP00084A","url":null,"abstract":"Covering: 2015 to 2022 Staphylococcus aureus (S. aureus) is responsible for several community and hospital-acquired infections with life-threatening complications such as bacteraemia, endocarditis, meningitis, liver abscess, and spinal cord epidural abscess. In recent decades, the abuse and misuse of antibiotics in humans, animals, plants, and fungi and the treatment of nonmicrobial diseases have led to the rapid emergence of multidrug-resistant pathogens. The bacterial wall is a complex structure consisting of the cell membrane, peptidoglycan cell wall, and various associated polymers. The enzymes involved in bacterial cell wall synthesis are established antibiotic targets and continue to be a central focus for antibiotic development. Natural products play a vital role in drug discovery and development. Importantly, natural products provide a starting point for active/lead compounds that sometimes need modification based on structural and biological properties to meet the drug criteria. Notably, microorganisms and plant metabolites have contributed as antibiotics for noninfectious diseases. In this study, we have summarized the recent advances in understanding the activity of the drugs or agents of natural origin that directly inhibit the bacterial membrane, membrane components, and membrane biosynthetic enzymes by targeting membrane-embedded proteins. We also discussed the unique aspects of the active mechanisms of established antibiotics or new agents.","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":null,"pages":null},"PeriodicalIF":11.9,"publicationDate":"2023-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49670916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cyanophycin and its biosynthesis: not hot but very cool 蓝藻素及其生物合成:不热但很冷

IF 11.9 1区化学

Natural Product Reports Pub Date : 2023-05-26 DOI: 10.1039/D2NP00092J

Itai Sharon, Donald Hilvert and T. Martin Schmeing

{"title":"Cyanophycin and its biosynthesis: not hot but very cool","authors":"Itai Sharon, Donald Hilvert and T. Martin Schmeing","doi":"10.1039/D2NP00092J","DOIUrl":"https://doi.org/10.1039/D2NP00092J","url":null,"abstract":"Covering: 1878 to early 2023Cyanophycin is a biopolymer consisting of a poly-aspartate backbone with arginines linked to each Asp sidechain through isopeptide bonds. Cyanophycin is made by cyanophycin synthetase 1 or 2 through ATP-dependent polymerization of Asp and Arg, or β-Asp-Arg, respectively. It is degraded into dipeptides by exo-cyanophycinases, and these dipeptides are hydrolyzed into free amino acids by general or dedicated isodipeptidase enzymes. When synthesized, chains of cyanophycin coalesce into large, inert, membrane-less granules. Although discovered in cyanobacteria, cyanophycin is made by species throughout the bacterial kingdom, and cyanophycin metabolism provides advantages for toxic bloom forming algae and some human pathogens. Some bacteria have developed dedicated schemes for cyanophycin accumulation and use, which include fine temporal and spatial regulation. Cyanophycin has also been heterologously produced in a variety of host organisms to a remarkable level, over 50% of the host's dry mass, and has potential for a variety of green industrial applications. In this review, we summarize the progression of cyanophycin research, with an emphasis on recent structural studies of enzymes in the cyanophycin biosynthetic pathway. These include several unexpected revelations that show cyanophycin synthetase to be a very cool, multi-functional macromolecular machine.","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":null,"pages":null},"PeriodicalIF":11.9,"publicationDate":"2023-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24849495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Structural advances toward understanding the catalytic activity and conformational dynamics of modular nonribosomal peptide synthetases 模块化非核糖体肽合成酶催化活性和构象动力学的结构研究进展

IF 11.9 1区化学

Natural Product Reports Pub Date : 2023-04-28 DOI: 10.1039/D3NP00003F

Ketan D. Patel, Monica R. MacDonald, Syed Fardin Ahmed, Jitendra Singh and Andrew M. Gulick

{"title":"Structural advances toward understanding the catalytic activity and conformational dynamics of modular nonribosomal peptide synthetases","authors":"Ketan D. Patel, Monica R. MacDonald, Syed Fardin Ahmed, Jitendra Singh and Andrew M. Gulick","doi":"10.1039/D3NP00003F","DOIUrl":"https://doi.org/10.1039/D3NP00003F","url":null,"abstract":"Covering: up to fall 2022.Nonribosomal peptide synthetases (NRPSs) are a family of modular, multidomain enzymes that catalyze the biosynthesis of important peptide natural products, including antibiotics, siderophores, and molecules with other biological activity. The NRPS architecture involves an assembly line strategy that tethers amino acid building blocks and the growing peptides to integrated carrier protein domains that migrate between different catalytic domains for peptide bond formation and other chemical modifications. Examination of the structures of individual domains and larger multidomain proteins has identified conserved conformational states within a single module that are adopted by NRPS modules to carry out a coordinated biosynthetic strategy that is shared by diverse systems. In contrast, interactions between modules are much more dynamic and do not yet suggest conserved conformational states between modules. Here we describe the structures of NRPS protein domains and modules and discuss the implications for future natural product discovery.","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":null,"pages":null},"PeriodicalIF":11.9,"publicationDate":"2023-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2023/np/d3np00003f?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24849498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2