Natural Product Reports最新文献_第9页

Fe(ii) and 2-oxoglutarate-dependent dioxygenases for natural product synthesis: molecular insights into reaction diversity 用于天然产物合成的铁(II)和 2-氧代戊二酸二氧酶：对反应多样性的分子认识。

IF 10.2 1区化学

Natural Product Reports Pub Date : 2024-11-14 DOI: 10.1039/d4np00030g

Songyin Zhao , Lunjie Wu , Yan Xu , Yao Nie

{"title":"Fe(ii) and 2-oxoglutarate-dependent dioxygenases for natural product synthesis: molecular insights into reaction diversity","authors":"Songyin Zhao , Lunjie Wu , Yan Xu , Yao Nie","doi":"10.1039/d4np00030g","DOIUrl":"10.1039/d4np00030g","url":null,"abstract":"<div><div>Covering: up to 2024</div></div><div><div>Fe(<span>ii</span>) and 2-oxoglutarate-dependent dioxygenases (Fe/2OG DOs) are a superfamily of enzymes that play important roles in a variety of catalytic reactions, including hydroxylation, ring formation, ring reconstruction, desaturation, and demethylation. Each member of this family has similarities in their overall structure, but they have varying specific differences, making Fe/2OG DOs attractive for catalytic diversity. With the advancement of current research, more Fe/2OG DOs have been discovered, and their catalytic scope has been further broadened; however, apart from hydroxylation, many reaction mechanisms have not been accurately demonstrated, and there is a lack of a systematic understanding of their molecular basis. Recently, an increasing number of X-ray structures of Fe/2OG DOs have provided new insights into the structural basis of their function and substrate-binding properties. This structural information is essential for understanding catalytic mechanisms and mining potential catalytic reactions. In this review, we summarize most of the Fe/2OG DOs whose structures have been resolved in recent years, focus on their structural features, and explore the relationships between various structural elements and unique catalytic mechanisms and their associated reaction type classification.</div></div>","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":"42 1","pages":"Pages 67-92"},"PeriodicalIF":10.2,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142453667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IF 10.2 1区化学

Natural Product Reports Pub Date : 2024-11-14 DOI: 10.1039/d4np00025k

Shengxin Sun , Xia Wang , Nvdan Hu , Shiqi Fu , Shengkun Li

{"title":"Siccanin-related drimane meroterpenoids: biological activities and synthesis†‡","authors":"Shengxin Sun , Xia Wang , Nvdan Hu , Shiqi Fu , Shengkun Li","doi":"10.1039/d4np00025k","DOIUrl":"10.1039/d4np00025k","url":null,"abstract":"<div><div>Covering: 1962 to 2023</div></div><div><div>Drimane (hydro)quinones biosynthetically arise from the combination of drimane-type terpenoids with phenols or equivalents. Since the isolation of siccanin in 1962 (structure identified in 1967), over 200 natural drimane (hydro)quinones have been reported. They are widespread with remarkably diverse architectures and biological functions, which are achieved by varying either the drimane subunit, hydroquinone segment, or the fusion types of drimane and hydroquinone segment both of them. This type of natural products has drawn increasing attention in the discovery of novel pharmaceutical leads. Enormous efforts have been devoted to developing efficient and divergent synthesis approaches to facilitate the SAR study of drimane (hydro)quinones, aiming for more promising functional leads. This review is arranged mainly in terms of scaffold types of drimane (hydro)quinones and further categorized on the basis of biological functions. The mechanisms of action are also briefly discussed. Synthetic methods are categorized according to the strategies forging the Csp<sup>2</sup>–Csp<sup>3</sup> linker between drimane segments and (hydro)quinone subunits.</div></div>","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":"42 1","pages":"Pages 113-150"},"PeriodicalIF":10.2,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142566518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chemical diversity of cyanobacterial natural products† 蓝藻天然产品的化学多样性。

IF 10.2 1区化学

Natural Product Reports Pub Date : 2024-11-14 DOI: 10.1039/d4np00040d

Márcio B. Weiss , Ricardo M. Borges , Peter Sullivan , João P. B. Domingues , Francisco H. S. da Silva , Victória G. S. Trindade , Shangwen Luo , Jimmy Orjala , Camila M. Crnkovic

引用次数: 0

Volatile organic compounds (VOCs) in terrestrial extreme environments: implications for life detection beyond Earth 陆地极端环境中的挥发性有机化合物（VOCs）：对地球以外生命探测的影响。

IF 10.2 1区化学

Natural Product Reports Pub Date : 2024-11-14 DOI: 10.1039/d4np00037d

Claire A. Batty , Victoria K. Pearson , Karen Olsson-Francis , Geraint Morgan

{"title":"Volatile organic compounds (VOCs) in terrestrial extreme environments: implications for life detection beyond Earth","authors":"Claire A. Batty , Victoria K. Pearson , Karen Olsson-Francis , Geraint Morgan","doi":"10.1039/d4np00037d","DOIUrl":"10.1039/d4np00037d","url":null,"abstract":"<div><div>Covering: 1961 to 2024</div></div><div><div>Discovering and identifying unique natural products/biosignatures (signatures that can be used as evidence for past or present life) that are abundant, and complex enough that they indicate robust evidence of life is a multifaceted process. One distinct category of biosignatures being explored is organic compounds. A subdivision of these compounds not yet readily investigated are volatile organic compound (VOCs). When assessing these VOCs as a group (volatilome) a fingerprint of all VOCs within an environment allows the complex patterns in metabolic data to be unravelled. As a technique already successfully applied to many biological and ecological fields, this paper explores how analysis of volatilomes in terrestrial extreme environments could be used to enhance processes (such as metabolomics and metagenomics) already utilised in life detection beyond Earth. By overcoming some of the complexities of collecting VOCs in remote field sites, a variety of lab based analytical equipment and techniques can then be utilised. Researching volatilomics in astrobiology requires time to characterise the patterns of VOCs. They must then be differentiated from abiotic (non-living) signals within extreme environments similar to those found on other planetary bodies (analogue sites) or in lab-based simulated environments or microcosms. Such an effort is critical for understanding data returned from past or upcoming missions, but it requires a step change in approach which explores the volatilome as a vital additional tool to current ‘Omics techniques.</div></div>","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":"42 1","pages":"Pages 93-112"},"PeriodicalIF":10.2,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/np/d4np00037d?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142453668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthetic-bioinformatic natural product-inspired peptides† 合成生物信息学天然产品启发肽。

IF 10.2 1区化学

Natural Product Reports Pub Date : 2024-11-14 DOI: 10.1039/d4np00043a

Samantha Nelson , Elizabeth I. Parkinson

{"title":"Synthetic-bioinformatic natural product-inspired peptides†","authors":"Samantha Nelson , Elizabeth I. Parkinson","doi":"10.1039/d4np00043a","DOIUrl":"10.1039/d4np00043a","url":null,"abstract":"<div><div>Covering: 2016 to 2024</div></div><div><div>Natural products, particularly cyclic peptides, are a promising source of bioactive compounds. Nonribosomal peptide synthetases (NRPSs) play a key role in biosynthesizing these compounds, which include antibiotic and anticancer agents, immunosuppressants, and others. Traditional methods of discovering natural products have limitations including cryptic biosynthetic gene clusters (BGCs), low titers, and currently unculturable organisms. This has prompted the exploration of alternative approaches. Synthetic-bioinformatic natural products (<em>syn</em>-BNPs) are one such alternative that utilizes bioinformatics techniques to predict nonribosomal peptides (NRPs) followed by chemical synthesis of the predicted peptides. This approach has shown promise, resulting in the discovery of a variety of bioactive compounds including peptides with antibacterial, antifungal, anticancer, and proteasome-stimulating activities. Despite the success of this approach, challenges remain especially in the accurate prediction of fatty acid incorporation, tailoring enzyme modifications, and peptide release mechanisms. Further work in these areas will enable the discovery of many bioactive peptides that are currently inaccessible.</div></div>","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":"42 1","pages":"Pages 50-66"},"PeriodicalIF":10.2,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11525955/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142542952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Accelerating enzyme discovery and engineering with high-throughput screening. 通过高通量筛选加速酶的发现和工程化。

IF 10.2 1区化学

Natural Product Reports Pub Date : 2024-10-15 DOI: 10.1039/d4np00031e

Eray U Bozkurt, Emil C Ørsted, Daniel C Volke, Pablo I Nikel

{"title":"Accelerating enzyme discovery and engineering with high-throughput screening.","authors":"Eray U Bozkurt, Emil C Ørsted, Daniel C Volke, Pablo I Nikel","doi":"10.1039/d4np00031e","DOIUrl":"10.1039/d4np00031e","url":null,"abstract":"<p><p>Covering: up to August 2024Enzymes play an essential role in synthesizing value-added chemicals with high specificity and selectivity. Since enzymes utilize substrates derived from renewable resources, biocatalysis offers a pathway to an efficient bioeconomy with reduced environmental footprint. However, enzymes have evolved over millions of years to meet the needs of their host organisms, which often do not align with industrial requirements. As a result, enzymes frequently need to be tailored for specific industrial applications. Combining enzyme engineering with high-throughput screening has emerged as a key approach for developing novel biocatalysts, but several challenges are yet to be addressed. In this review, we explore emergent strategies and methods for isolating, creating, and characterizing enzymes optimized for bioproduction. We discuss fundamental approaches to discovering and generating enzyme variants and identifying those best suited for specific applications. Additionally, we cover techniques for creating libraries using automated systems and highlight innovative high-throughput screening methods that have been successfully employed to develop novel biocatalysts for natural product synthesis.</p>","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":" ","pages":""},"PeriodicalIF":10.2,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142453666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Structural diversity and chemical logic underlying the assembly of monoterpene indole alkaloids oligomers†‡ 单萜吲哚生物碱低聚物组装的结构多样性和化学逻辑

IF 10.2 1区化学

Natural Product Reports Pub Date : 2024-09-18 DOI: 10.1039/d4np00011k

Pierre Le Pogam , Mehdi A. Beniddir

{"title":"Structural diversity and chemical logic underlying the assembly of monoterpene indole alkaloids oligomers†‡","authors":"Pierre Le Pogam , Mehdi A. Beniddir","doi":"10.1039/d4np00011k","DOIUrl":"10.1039/d4np00011k","url":null,"abstract":"<div><div>Covering: up to 2024</div></div><div><div>This review aims to draw a parallel between all known oligomers of monoterpene indole alkaloids (MIAs) by illustrating the chemical logic underlying their assembly. For this purpose, oligomeric MIAs were first comprehensively listed and organized according to the names of the backbones of their constitutive monomers and the binding sites. From this extensive list, an oligomer network was generated and unprecedented MIA statistics were mined and shared herein. Subsequently, oligomeric MIAs were categorized according to the number of connections instigated between their monomeric components (single, double, triple, and mixed tethering), then subdivided according to the uniqueness or combination of oligomerization assembly reactions. This effort outlined oligomerization trends in a scaffold-specific manner, and established binding reactivity patterns facilitating the comprehension of the associated biosynthetic processes. At last, this review illustrates a unique initiative in crafting a comprehensive repository of machine-readable metadata for MIA oligomers that could be leveraged for chemoinformatic purposes.</div></div>","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":"41 11","pages":"Pages 1723-1765"},"PeriodicalIF":10.2,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2024/np/d4np00011k?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142178808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phytochemical and pharmacological properties of the genus Alpinia from 2016 to 2023 2016 年至 2023 年阿尔皮纳属的植物化学和药理特性。

IF 10.2 1区化学

Natural Product Reports Pub Date : 2024-09-18 DOI: 10.1039/d4np00004h

引用次数: 0

Terpenoids of plants from Chloranthaceae family: chemistry, bioactivity, and synthesis† 绿茶科植物的萜类化合物：化学、生物活性和合成。

IF 10.2 1区化学

Natural Product Reports Pub Date : 2024-09-18 DOI: 10.1039/d4np00005f

引用次数: 0

Unleashing the potential: type I CRISPR-Cas systems in actinomycetes for genome editing 释放潜能：放线菌中用于基因组编辑的 I 型 CRISPR-Cas 系统。

IF 10.2 1区化学

Natural Product Reports Pub Date : 2024-09-18 DOI: 10.1039/d4np00010b

{"title":"Unleashing the potential: type I CRISPR-Cas systems in actinomycetes for genome editing","authors":"","doi":"10.1039/d4np00010b","DOIUrl":"10.1039/d4np00010b","url":null,"abstract":"<div><div>Covering: up to the end of 2023</div></div><div><div>Type I CRISPR-Cas systems are widely distributed, found in over 40% of bacteria and 80% of archaea. Among genome-sequenced actinomycetes (particularly <em>Streptomyces</em> spp.), 45.54% possess type I CRISPR-Cas systems. In comparison to widely used CRISPR systems like Cas9 or Cas12a, these endogenous CRISPR-Cas systems have significant advantages, including better compatibility, wide distribution, and ease of operation (since no exogenous Cas gene delivery is needed). Furthermore, type I CRISPR-Cas systems can simultaneously edit and regulate genes by adjusting the crRNA spacer length. Meanwhile, most actinomycetes are recalcitrant to genetic manipulation, hindering the discovery and engineering of natural products (NPs). The endogenous type I CRISPR-Cas systems in actinomycetes may offer a promising alternative to overcome these barriers. This review summarizes the challenges and recent advances in CRISPR-based genome engineering technologies for actinomycetes. It also presents and discusses how to establish and develop genome editing tools based on type I CRISPR-Cas systems in actinomycetes, with the aim of their future application in gene editing and the discovery of NPs in actinomycetes.</div></div>","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":"41 9","pages":"Pages 1441-1455"},"PeriodicalIF":10.2,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141416726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0