Chemical Reviews最新文献

Unraveling Materials Synthesis Mechanisms Using In Situ Transmission Electron Microscopy and Neutron Scattering. 利用原位透射电镜和中子散射揭示材料合成机制。

IF 62.1 1区化学

Chemical Reviews Pub Date : 2025-09-06 DOI: 10.1021/acs.chemrev.5c00063

Jacob Smith,Hwangsun Kim,Ke An,Yan Chen,Ondrej Dyck,Kate Reidy,Miaofang Chi

{"title":"Unraveling Materials Synthesis Mechanisms Using In Situ Transmission Electron Microscopy and Neutron Scattering.","authors":"Jacob Smith,Hwangsun Kim,Ke An,Yan Chen,Ondrej Dyck,Kate Reidy,Miaofang Chi","doi":"10.1021/acs.chemrev.5c00063","DOIUrl":"https://doi.org/10.1021/acs.chemrev.5c00063","url":null,"abstract":"Achieving precise control of materials synthesis is a cornerstone of modern manufacturing, driving efficiency, functionality, and device innovation. This review examines the roles of in situ transmission electron microscopy (TEM) and neutron scattering (NS) in advancing our understanding of these processes. In situ TEM offers atomic-scale insights into nucleation, growth, and phase transitions, while NS provides an analysis of reaction pathways, phase evolution, and structural transformations over broader length scales. Recent advancements in hardware have greatly improved spatial, temporal, and environmental control in in situ experiments. TEM enables breakthroughs in thermally controlled synthesis, gas-phase deposition, and beam-induced fabrication, including single-atom device creation. NS, particularly in situ neutron diffraction and imaging, are essential for studying bulk-level synthesis pathways. Together, these techniques offer a multiscale view of synthesis and processing. Integrating artificial intelligence (AI), automated workflows, and multimodal characterization is highlighted as a path toward high-throughput, predictive synthesis. By discussing challenges and opportunities in instrumentation and analysis, this review proposes a multiscale approach to accelerate innovation in materials synthesis, with applications across energy storage, quantum materials, and next-generation manufacturing.","PeriodicalId":32,"journal":{"name":"Chemical Reviews","volume":"96 1","pages":""},"PeriodicalIF":62.1,"publicationDate":"2025-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145003267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gel-Based Ionic Circuits. 凝胶基离子电路。

IF 55.8 1区化学

Chemical Reviews Pub Date : 2025-09-02 DOI: 10.1021/acs.chemrev.5c00245

Hyunjae Yoo, Yun Hyeok Lee, Min-Gyu Lee, Jeong-Yun Sun

引用次数: 0

Probing Surface/Bulk Structural Chemistry of Key Components of Solid Oxide Electrochemical Cells with In Situ/Operando Raman Spectroscopy. 用原位/操作拉曼光谱探测固体氧化物电化学电池关键组分的表面/体结构化学。

IF 55.8 1区化学

Chemical Reviews Pub Date : 2025-08-28 DOI: 10.1021/acs.chemrev.5c00222

Neelesh Kumar, Musa O Najimu, Yoon Jin Cho, Kandis Leslie Gilliard-AbdulAziz, Eranda Nikolla, Zili Wu, Israel E Wachs

{"title":"Probing Surface/Bulk Structural Chemistry of Key Components of Solid Oxide Electrochemical Cells with In Situ/Operando Raman Spectroscopy.","authors":"Neelesh Kumar, Musa O Najimu, Yoon Jin Cho, Kandis Leslie Gilliard-AbdulAziz, Eranda Nikolla, Zili Wu, Israel E Wachs","doi":"10.1021/acs.chemrev.5c00222","DOIUrl":"https://doi.org/10.1021/acs.chemrev.5c00222","url":null,"abstract":"The remarkable attributes of solid oxide electrochemical cell technology (e.g., energy efficiency, low cost, scalability, low emissions, and operational flexibility, etc.) drive the wider adoption of electrochemical conversion routes for sustainability. It is critical for the codevelopment of solid oxide cell materials and processes to establish the mechanistic understanding of the underlying chemical phenomena at the molecular level. Herein, we summarize the advancements in Raman spectroscopy that provide structural/molecular information on electrode/electrolyte materials typically used in solid oxide cells for energy conversion. In particular, we discuss the multifactorial environment induced chemical processes that govern the performance and longevity of solid oxide electrochemical devices. The in situ/operando Raman spectroscopic investigations on the electrode/electrolyte materials reported in the literature are summarized with the emphasis on identification of key material properties that control the functional aspects of the solid oxide cells. The molecular level understanding of the electrochemical processes will allow advancement of the rational design of electrochemical materials for process level deployment of solid oxide cell technology.","PeriodicalId":32,"journal":{"name":"Chemical Reviews","volume":" ","pages":""},"PeriodicalIF":55.8,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144935590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Site-Specific Transformable Nanostructures for Cancer Therapy and Diagnosis. 用于癌症治疗和诊断的位点特异性可转换纳米结构。

IF 55.8 1区化学

Chemical Reviews Pub Date : 2025-08-21 DOI: 10.1021/acs.chemrev.5c00297

Jungryun Kim, Yubin Lee, Yuri Kim, Hyeonji Rha, Dongeun Kim, Snehasish Debnath, Kanyi Pu, Heemin Kang, Jong Seung Kim

{"title":"Site-Specific Transformable Nanostructures for Cancer Therapy and Diagnosis.","authors":"Jungryun Kim, Yubin Lee, Yuri Kim, Hyeonji Rha, Dongeun Kim, Snehasish Debnath, Kanyi Pu, Heemin Kang, Jong Seung Kim","doi":"10.1021/acs.chemrev.5c00297","DOIUrl":"https://doi.org/10.1021/acs.chemrev.5c00297","url":null,"abstract":"Tumor heterogeneity and complex morphologies pose significant challenges to achieving efficient therapeutic outcomes. However, the recent advent of remote-controlled transformable nanostructures has introduced a novel approach to cancer therapy, enabling precise size, shape, and phase changes in nanoparticles in response to external stimuli, such as light, ultrasound, and magnetic fields. These materials offer noninvasive strategies to effectively navigate the dynamic and complex morphologies of tumors, providing unprecedented control over therapeutic targeting and precision in patient-tailored treatments. The real-time modulation of nanomaterial structures optimizes interactions with the tumor microenvironment, improving circulation, endothelial permeation, deep tumor penetration, and subcellular targeting. This review discusses cutting-edge strategies to remotely control the morphology of nanomaterials, emphasizing their integration into modular cancer theranostic platforms. These systems are engineered to target cancer cell membrane receptors and cytoplasm, subcellular organelles, immune cells, and difficult-to-reach areas including the blood-brain barrier and deep-seated tumors. We also explore the potential of multimodal theranostics including dual-triggered, combinatorial, and synergistic therapies that combine therapeutic action with real-time imaging guidance. This review presents a clear and insightful roadmap, unveiling how these cutting-edge advancements open new horizons for adaptive, personalized therapies with exceptional potential to overcome the complexities of metastatic tumor treatment and advance clinical translation.","PeriodicalId":32,"journal":{"name":"Chemical Reviews","volume":" ","pages":""},"PeriodicalIF":55.8,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144935741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Retraction of “Soft-Matter Nanotubes: A Platform for Diverse Functions and Applications” 撤回“软物质纳米管：多种功能和应用的平台”。

IF 55.8 1区化学

Chemical Reviews Pub Date : 2025-08-13 DOI: 10.1021/acs.chemrev.5c00539

Toshimi Shimizu*, Wuxiao Ding and Naohiro Kameta*,

引用次数: 0

Introduction: Electric Fields in Chemistry and Biology 导论：化学和生物学中的电场

IF 55.8 1区化学

Chemical Reviews Pub Date : 2025-08-13 DOI: 10.1021/acs.chemrev.5c00507

Steven G. Boxer*, and , Teresa Head-Gordon*,

引用次数: 0

Photoexcited Active Radicals for Environmental and Energy Applications: Generation, Regulation, and Dynamic Tracking 光激发活性自由基在环境和能源中的应用：产生、调节和动态跟踪。

IF 55.8 1区化学

Chemical Reviews Pub Date : 2025-08-12 DOI: 10.1021/acs.chemrev.5c00074

Jielin Wang, Shujie Shen, Xin Li, Jieyuan Li* and Fan Dong*,

{"title":"Photoexcited Active Radicals for Environmental and Energy Applications: Generation, Regulation, and Dynamic Tracking","authors":"Jielin Wang, Shujie Shen, Xin Li, Jieyuan Li* and Fan Dong*, ","doi":"10.1021/acs.chemrev.5c00074","DOIUrl":"10.1021/acs.chemrev.5c00074","url":null,"abstract":"Photoexcited reactive radicals play a crucial role in environmental and energy processes, driving reactions such as pollutant degradation and solar energy conversion. Although rapid advances in this area have been achieved, several vital issues still need to be addressed, such as poor selectivity for radical generation, undefined pathways for radical transformation, and inconsistent dynamic detection of photoexcited radicals. This review provides a comprehensive overview of photogenerated reactive radicals in environmental and energy applications. First, the formation and transformation processes of common radicals are summarized, elucidating their key roles in photochemical reactions. Then, the strategies for regulating specific radicals are illustrated, offering insights into their efficient utilization to guide future energy and environmental reactions. Subsequently, it reviews cutting-edge work on dynamic tracking of radicals, including real-time monitoring techniques in complex matrices. Finally, it critically examines existing deficiencies and inaccuracies in radical studies, highlighting the need for more precise detection methods and theoretical frameworks. By providing insights into the relationship between radical selectivity and reaction efficiency, this review offers a comprehensive overview of advances in the diverse aspects of photoexcited radicals, thereby illuminating future opportunities in sustainable chemistry and environmental sciences.","PeriodicalId":32,"journal":{"name":"Chemical Reviews","volume":"125 16","pages":"7811–7917"},"PeriodicalIF":55.8,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144833467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fluoropolymers in Medical Applications: Recent Progress and Development 含氟聚合物在医学上的应用：最新进展和发展。

IF 55.8 1区化学

Chemical Reviews Pub Date : 2025-08-12 DOI: 10.1021/acs.chemrev.4c00996

Chadron M. Friesen*, and , Jason Pulfer*,

引用次数: 0

Chemical Control of Genes: Synthetic Genome Readers and Gene Regulators 基因的化学控制：合成基因组解读器和基因调控器。

IF 55.8 1区化学

Chemical Reviews Pub Date : 2025-08-11 DOI: 10.1021/acs.chemrev.5c00112

Aseem Z. Ansari*, Ashraf Mohammed, Anushree Achari, Adithi Danda, Steven J. Philips, Caitlin D. Deane and Suresh K. Kandikonda,

{"title":"Chemical Control of Genes: Synthetic Genome Readers and Gene Regulators","authors":"Aseem Z. Ansari*, Ashraf Mohammed, Anushree Achari, Adithi Danda, Steven J. Philips, Caitlin D. Deane and Suresh K. Kandikonda, ","doi":"10.1021/acs.chemrev.5c00112","DOIUrl":"10.1021/acs.chemrev.5c00112","url":null,"abstract":"Selective control of gene expression with small molecules has been a long-standing goal at the interface of chemistry and medicine. The ability to selectively regulate disease-driver genes with small molecules would transform the treatment of numerous human diseases. Small molecule modulators of proteins that enable gene transcription, including kinases, chromatin-modifying enzymes, and transcription factors (TFs) have proven invaluable as mechanistic probes and therapeutic agents. However, these molecules perturb gene regulatory processes broadly, often eliciting adverse outcomes and operating within narrow therapeutic ranges. Here, we describe the development of sequence-targeted synthetic gene regulators (SynGRs) that address these issues. Built with programmable DNA-binding polyamides, first-generation SynGRs were employed to inhibit gene expression by blocking the binding of TFs to regulatory sites. By contrast, gene-targeting chimeras that function as molecular glues to recruit the transcriptional machinery to targeted genes were developed to stimulate expression of desired gene(s). Since their advent in 2000, diverse classes of SynGRs have been reported, including artificial/synthetic TFs, protein–DNA dimerizers, and chromatin modifiers. Further integration of the principles of cooperative assembly and selectivity has yielded tunable SynGRs that regulate single disease-driver genes and are progressing as first-in-class therapeutic agents. The ability to rationally “drug” disease-driver genes is now within reach.","PeriodicalId":32,"journal":{"name":"Chemical Reviews","volume":"125 16","pages":"8024–8048"},"PeriodicalIF":55.8,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144812872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fabrication of Soft Robotics by Additive Manufacturing: From Materials to Applications 用增材制造制造软机器人：从材料到应用。

IF 55.8 1区化学

Chemical Reviews Pub Date : 2025-08-11 DOI: 10.1021/acs.chemrev.4c00749

Ouriel Bliah, Chidanand Hegde, Joel Ming Rui Tan and Shlomo Magdassi*,

{"title":"Fabrication of Soft Robotics by Additive Manufacturing: From Materials to Applications","authors":"Ouriel Bliah, Chidanand Hegde, Joel Ming Rui Tan and Shlomo Magdassi*, ","doi":"10.1021/acs.chemrev.4c00749","DOIUrl":"10.1021/acs.chemrev.4c00749","url":null,"abstract":"Soft robotics is a rapidly evolving field that leverages the unique properties of compliant, flexible materials to create robots that are capable of complex and adaptive behaviors. Unlike traditional rigid robots, soft robots rely on the properties of soft materials, which enable them to safely interact with humans, manipulate delicate objects, and perform various locomotion processes. This review provides a comprehensive overview of the development process of soft robots by additive manufacturing with a particular focus on the chemical aspects of the materials involved. The types of materials used in soft robotics, highlighting their properties, applications, and the role of their chemical composition in performance, are presented. The review then explores fabrication methods, detailing their chemical underpinnings, advantages, and limitations, followed by presenting common design methods used to optimize soft robots. Finally, the review discusses the diverse applications of soft robots across various domains, including medical, locomotion, manipulation, and wearable devices. By covering every stage of the additive manufactured soft robot, from material selection to application, this review aims to offer a deep and comprehensive understanding of this field.","PeriodicalId":32,"journal":{"name":"Chemical Reviews","volume":"125 16","pages":"7275–7320"},"PeriodicalIF":55.8,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acs.chemrev.4c00749","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144820142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0