Chemical Reviews最新文献

Exploring the Potential of Nonclassical Crystallization Pathways to Advance Cementitious Materials. 探索非经典结晶途径的潜力，促进水泥基材料的发展。

IF 51.4 1区化学

Chemical Reviews Pub Date : 2024-06-26 Epub Date: 2024-06-14 DOI: 10.1021/acs.chemrev.3c00259

Cristina Ruiz-Agudo, Helmut Cölfen

{"title":"Exploring the Potential of Nonclassical Crystallization Pathways to Advance Cementitious Materials.","authors":"Cristina Ruiz-Agudo, Helmut Cölfen","doi":"10.1021/acs.chemrev.3c00259","DOIUrl":"10.1021/acs.chemrev.3c00259","url":null,"abstract":"Understanding the crystallization of cement-binding phases, from basic units to macroscopic structures, can enhance cement performance, reduce clinker use, and lower CO2 emissions in the construction sector. This review examines the crystallization pathways of C-S-H (the main phase in PC cement) and other alternative binding phases, particularly as cement formulations evolve toward increasing SCMs and alternative binders as clinker replacements. We adopt a nonclassical crystallization perspective, which recognizes the existence of critical intermediate steps between ions in solution and the final crystalline phases, such as solute ion associates, dense liquid phases, amorphous intermediates, and nanoparticles. These multistep pathways uncover innovative strategies for controlling the crystallization of binding phases through additive use, potentially leading to highly optimized cement matrices. An outstanding example of additive-controlled crystallization in cementitious materials is the synthetically produced mesocrystalline C-S-H, renowned for its remarkable flexural strength. This highly ordered microstructure, which intercalates soft matter between inorganic and brittle C-S-H, was obtained by controlling the assembly of individual C-S-H subunits. While large-scale production of cementitious materials by a bottom-up self-assembly method is not yet feasible, the fundamental insights into the crystallization mechanism of cement binding phases presented here provide a foundation for developing advanced cement-based materials.","PeriodicalId":32,"journal":{"name":"Chemical Reviews","volume":null,"pages":null},"PeriodicalIF":51.4,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141315982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Introduction: Ionic Liquids for Diverse Applications. 导言：用于多种应用的离子液体。

IF 51.4 1区化学

Chemical Reviews Pub Date : 2024-06-26 DOI: 10.1021/acs.chemrev.4c00291

Zhigang Lei, Chengna Dai, Jason Hallett, Mark Shiflett

引用次数: 0

Ultrasound-Based Micro-/Nanosystems for Biomedical Applications.

IF 51.4 1区化学

Chemical Reviews Pub Date : 2024-06-26 DOI: 10.1021/acs.chemrev.4c00009

Hui Huang, Yi Zheng, Meiqi Chang, Jun Song, Lili Xia, Chenyao Wu, Wencong Jia, Hongze Ren, Wei Feng, Yu Chen

{"title":"Ultrasound-Based Micro-/Nanosystems for Biomedical Applications.","authors":"Hui Huang, Yi Zheng, Meiqi Chang, Jun Song, Lili Xia, Chenyao Wu, Wencong Jia, Hongze Ren, Wei Feng, Yu Chen","doi":"10.1021/acs.chemrev.4c00009","DOIUrl":"https://doi.org/10.1021/acs.chemrev.4c00009","url":null,"abstract":"Due to the intrinsic non-invasive nature, cost-effectiveness, high safety, and real-time capabilities, besides diagnostic imaging, ultrasound as a typical mechanical wave has been extensively developed as a physical tool for versatile biomedical applications. Especially, the prosperity of nanotechnology and nanomedicine invigorates the landscape of ultrasound-based medicine. The unprecedented surge in research enthusiasm and dedicated efforts have led to a mass of multifunctional micro-/nanosystems being applied in ultrasound biomedicine, facilitating precise diagnosis, effective treatment, and personalized theranostics. The effective deployment of versatile ultrasound-based micro-/nanosystems in biomedical applications is rooted in a profound understanding of the relationship among composition, structure, property, bioactivity, application, and performance. In this comprehensive review, we elaborate on the general principles regarding the design, synthesis, functionalization, and optimization of ultrasound-based micro-/nanosystems for abundant biomedical applications. In particular, recent advancements in ultrasound-based micro-/nanosystems for diagnostic imaging are meticulously summarized. Furthermore, we systematically elucidate state-of-the-art studies concerning recent progress in ultrasound-based micro-/nanosystems for therapeutic applications targeting various pathological abnormalities including cancer, bacterial infection, brain diseases, cardiovascular diseases, and metabolic diseases. Finally, we conclude and provide an outlook on this research field with an in-depth discussion of the challenges faced and future developments for further extensive clinical translation and application.","PeriodicalId":32,"journal":{"name":"Chemical Reviews","volume":null,"pages":null},"PeriodicalIF":51.4,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141453623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Versatile Landscape of Low-k Polyimide: Theories, Synthesis, Synergistic Properties, and Industrial Integration. 低 k 值聚酰亚胺的多面性：理论、合成、协同特性和工业整合。

IF 51.4 1区化学

Chemical Reviews Pub Date : 2024-06-26 Epub Date: 2024-06-07 DOI: 10.1021/acs.chemrev.3c00802

Xiaodi Dong, Baoquan Wan, Jun-Wei Zha

{"title":"Versatile Landscape of Low-k Polyimide: Theories, Synthesis, Synergistic Properties, and Industrial Integration.","authors":"Xiaodi Dong, Baoquan Wan, Jun-Wei Zha","doi":"10.1021/acs.chemrev.3c00802","DOIUrl":"10.1021/acs.chemrev.3c00802","url":null,"abstract":"The development of microelectronics and large-scale intelligence nowadays promotes the integration, miniaturization, and multifunctionality of electronic and devices but also leads to the increment of signal transmission delays, crosstalk, and energy consumption. The exploitation of materials with low permittivity (low-k) is crucial for realizing innovations in microelectronics. However, due to the high permittivity of conventional interlayer dielectric material (k ∼ 4.0), it is difficult to meet the demands of current microelectronic technology development (k < 3.0). Organic dielectric materials have attracted much attention because of their relatively low permittivity owing to their low material density and low single bond polarization. Polyimide (PI) exhibits better application potential based on its well permittivity tunability (k = 1.1-3.2), high thermal stability (>500 °C), and mechanical property (modulus of elasticity up to 3.0-4.0 GPa). In this review, based on the synergistic relationship of dielectric parameters of materials, the development of nearly 20 years on low-k PI is thoroughly summarized. Moreover, process strategies for modifying low-k PI at the molecular level, multiphase recombination, and interface engineering are discussed exhaustively. The industrial application, technological challenges, and future development of low-k PI are also analyzed, which will provide meaningful guidance for the design and practical application of multifunctional low-k materials.","PeriodicalId":32,"journal":{"name":"Chemical Reviews","volume":null,"pages":null},"PeriodicalIF":51.4,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141282256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthetic Methods for Azaheterocyclic Phosphonates and Their Biological Activity: An Update 2004-2024. 氮杂环膦酸盐的合成方法及其生物活性：2004-2024 年更新。

IF 51.4 1区化学

Chemical Reviews Pub Date : 2024-06-26 Epub Date: 2024-05-29 DOI: 10.1021/acs.chemrev.4c00090

Martha C Mayorquín-Torres, Andreas Simoens, Eli Bonneure, Christian V Stevens

{"title":"Synthetic Methods for Azaheterocyclic Phosphonates and Their Biological Activity: An Update 2004-2024.","authors":"Martha C Mayorquín-Torres, Andreas Simoens, Eli Bonneure, Christian V Stevens","doi":"10.1021/acs.chemrev.4c00090","DOIUrl":"10.1021/acs.chemrev.4c00090","url":null,"abstract":"The increasing importance of azaheterocyclic phosphonates in the agrochemical, synthetic, and medicinal field has provoked an intense search in the development of synthetic routes for obtaining novel members of this family of compounds. This updated review covers methodologies established since 2004, focusing on the synthesis of azaheterocyclic phosphonates, of which the phosphonate moiety is directly substituted onto to the azaheterocyclic structure. Emphasizing recent advances, this review classifies newly developed synthetic approaches according to the ring size and providing information on biological activities whenever available. Furthermore, this review summarizes information on various methods for the formation of C-P bonds, examining sustainable approaches such as the Michaelis-Arbuzov reaction, the Michaelis-Becker reaction, the Pudovik reaction, the Hirao coupling, and the Kabachnik-Fields reaction. After analyzing the biological activities and applications of azaheterocyclic phosphonates investigated in recent years, a predominant focus on the evaluation of these compounds as anticancer agents is evident. Furthermore, emerging applications underline the versatility and potential of these compounds, highlighting the need for continued research on synthetic methods to expand this interesting family.","PeriodicalId":32,"journal":{"name":"Chemical Reviews","volume":null,"pages":null},"PeriodicalIF":51.4,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141173832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanisms and Delivery of tRNA Therapeutics. tRNA 疗法的机制和传递。

IF 51.4 1区化学

Chemical Reviews Pub Date : 2024-06-26 Epub Date: 2024-05-27 DOI: 10.1021/acs.chemrev.4c00142

Cian Ward, Aruun Beharry, Rasangi Tennakoon, Peter Rozik, Sarah D P Wilhelm, Ilka U Heinemann, Patrick O'Donoghue

{"title":"Mechanisms and Delivery of tRNA Therapeutics.","authors":"Cian Ward, Aruun Beharry, Rasangi Tennakoon, Peter Rozik, Sarah D P Wilhelm, Ilka U Heinemann, Patrick O'Donoghue","doi":"10.1021/acs.chemrev.4c00142","DOIUrl":"10.1021/acs.chemrev.4c00142","url":null,"abstract":"Transfer ribonucleic acid (tRNA) therapeutics will provide personalized and mutation specific medicines to treat human genetic diseases for which no cures currently exist. The tRNAs are a family of adaptor molecules that interpret the nucleic acid sequences in our genes into the amino acid sequences of proteins that dictate cell function. Humans encode more than 600 tRNA genes. Interestingly, even healthy individuals contain some mutant tRNAs that make mistakes. Missense suppressor tRNAs insert the wrong amino acid in proteins, and nonsense suppressor tRNAs read through premature stop signals to generate full length proteins. Mutations that underlie many human diseases, including neurodegenerative diseases, cancers, and diverse rare genetic disorders, result from missense or nonsense mutations. Thus, specific tRNA variants can be strategically deployed as therapeutic agents to correct genetic defects. We review the mechanisms of tRNA therapeutic activity, the nature of the therapeutic window for nonsense and missense suppression as well as wild-type tRNA supplementation. We discuss the challenges and promises of delivering tRNAs as synthetic RNAs or as gene therapies. Together, tRNA medicines will provide novel treatments for common and rare genetic diseases in humans.","PeriodicalId":32,"journal":{"name":"Chemical Reviews","volume":null,"pages":null},"PeriodicalIF":51.4,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141157034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Topological Materials Go Meta. 拓扑材料走向元。

IF 51.4 1区化学

Chemical Reviews Pub Date : 2024-06-26 DOI: 10.1021/acs.chemrev.4c00439

Roel Tempelaar

引用次数: 0

The Versatile and Strategic O-Carbamate Directed Metalation Group in the Synthesis of Aromatic Molecules: An Update. 芳香族分子合成中的多功能战略性 O-氨基甲酸酯定向金属化基团：最新进展。

IF 51.4 1区化学

Chemical Reviews Pub Date : 2024-06-26 Epub Date: 2024-06-12 DOI: 10.1021/acs.chemrev.3c00923

Ross D Jansen-van Vuuren, Susana Liu, M A Jalil Miah, Janez Cerkovnik, Janez Košmrlj, Victor Snieckus

{"title":"The Versatile and Strategic O-Carbamate Directed Metalation Group in the Synthesis of Aromatic Molecules: An Update.","authors":"Ross D Jansen-van Vuuren, Susana Liu, M A Jalil Miah, Janez Cerkovnik, Janez Košmrlj, Victor Snieckus","doi":"10.1021/acs.chemrev.3c00923","DOIUrl":"10.1021/acs.chemrev.3c00923","url":null,"abstract":"The aryl O-carbamate (ArOAm) group is among the strongest of the directed metalation groups (DMGs) in directed ortho metalation (DoM) chemistry, especially in the form Ar-OCONEt2. Since the last comprehensive review of metalation chemistry involving ArOAms (published more than 30 years ago), the field has expanded significantly. For example, it now encompasses new substrates, solvent systems, and metalating agents, while conditions have been developed enabling metalation of ArOAm to be conducted in a green and sustainable manner. The ArOAm group has also proven to be effective in the anionic ortho-Fries (AoF) rearrangement, Directed remote metalation (DreM), iterative DoM sequences, and DoM-halogen dance (HalD) synthetic strategies and has been transformed into a diverse range of functionalities and coupled with various groups through a range of cross-coupling (CC) strategies. Of ultimate value, the ArOAm group has demonstrated utility in the synthesis of a diverse range of bioactive and polycyclic aromatic compounds for various applications.","PeriodicalId":32,"journal":{"name":"Chemical Reviews","volume":null,"pages":null},"PeriodicalIF":51.4,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141304776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

New Advances in Covalent Network Polymers via Dynamic Covalent Chemistry. 通过动态共价化学研究共价网络聚合物的新进展。

IF 51.4 1区化学

Chemical Reviews Pub Date : 2024-06-26 Epub Date: 2024-06-03 DOI: 10.1021/acs.chemrev.3c00926

Zepeng Lei, Hongxuan Chen, Shaofeng Huang, Lacey J Wayment, Qiucheng Xu, Wei Zhang

{"title":"New Advances in Covalent Network Polymers via Dynamic Covalent Chemistry.","authors":"Zepeng Lei, Hongxuan Chen, Shaofeng Huang, Lacey J Wayment, Qiucheng Xu, Wei Zhang","doi":"10.1021/acs.chemrev.3c00926","DOIUrl":"10.1021/acs.chemrev.3c00926","url":null,"abstract":"Covalent network polymers, as materials composed of atoms interconnected by covalent bonds in a continuous network, are known for their thermal and chemical stability. Over the past two decades, these materials have undergone significant transformations, gaining properties such as malleability, environmental responsiveness, recyclability, crystallinity, and customizable porosity, enabled by the development and integration of dynamic covalent chemistry (DCvC). In this review, we explore the innovative realm of covalent network polymers by focusing on the recent advances achieved through the application of DCvC. We start by examining the history and fundamental principles of DCvC, detailing its inception and core concepts and noting its key role in reversible covalent bond formation. Then the reprocessability of covalent network polymers enabled by DCvC is thoroughly discussed, starting from the significant milestones that marked the evolution of these polymers and progressing to their current trends and applications. The influence of DCvC on the crystallinity of covalent network polymers is then reviewed, covering their bond diversity, synthesis techniques, and functionalities. In the concluding section, we address the current challenges faced in the field of covalent network polymers and speculates on potential future directions.","PeriodicalId":32,"journal":{"name":"Chemical Reviews","volume":null,"pages":null},"PeriodicalIF":51.4,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141198562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biospecific Chemistry for Covalent Linking of Biomacromolecules. 用于生物大分子共价连接的生物特异性化学。

IF 51.4 1区化学

Chemical Reviews Pub Date : 2024-06-24 DOI: 10.1021/acs.chemrev.4c00066

Li Cao, Lei Wang

{"title":"Biospecific Chemistry for Covalent Linking of Biomacromolecules.","authors":"Li Cao, Lei Wang","doi":"10.1021/acs.chemrev.4c00066","DOIUrl":"https://doi.org/10.1021/acs.chemrev.4c00066","url":null,"abstract":"Interactions among biomacromolecules, predominantly noncovalent, underpin biological processes. However, recent advancements in biospecific chemistry have enabled the creation of specific covalent bonds between biomolecules, both in vitro and in vivo. This Review traces the evolution of biospecific chemistry in proteins, emphasizing the role of genetically encoded latent bioreactive amino acids. These amino acids react selectively with adjacent natural groups through proximity-enabled bioreactivity, enabling targeted covalent linkages. We explore various latent bioreactive amino acids designed to target different protein residues, ribonucleic acids, and carbohydrates. We then discuss how these novel covalent linkages can drive challenging protein properties and capture transient protein-protein and protein-RNA interactions in vivo. Additionally, we examine the application of covalent peptides as potential therapeutic agents and site-specific conjugates for native antibodies, highlighting their capacity to form stable linkages with target molecules. A significant focus is placed on proximity-enabled reactive therapeutics (PERx), a pioneering technology in covalent protein therapeutics. We detail its wide-ranging applications in immunotherapy, viral neutralization, and targeted radionuclide therapy. Finally, we present a perspective on the existing challenges within biospecific chemistry and discuss the potential avenues for future exploration and advancement in this rapidly evolving field.","PeriodicalId":32,"journal":{"name":"Chemical Reviews","volume":null,"pages":null},"PeriodicalIF":51.4,"publicationDate":"2024-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141445548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0