Chemical ReviewsPub Date : 2025-07-28DOI: 10.1021/acs.chemrev.4c00807
Joel Mieres-Perez, Yasser Almeida-Hernandez, Wolfram Sander, Elsa Sanchez-Garcia
{"title":"A Computational Perspective to Intermolecular Interactions and the Role of the Solvent on Regulating Protein Properties.","authors":"Joel Mieres-Perez, Yasser Almeida-Hernandez, Wolfram Sander, Elsa Sanchez-Garcia","doi":"10.1021/acs.chemrev.4c00807","DOIUrl":"https://doi.org/10.1021/acs.chemrev.4c00807","url":null,"abstract":"<p><p>Intermolecular interactions play a key role in determining and tuning the structure and function of proteins. Following a simplified conventional scheme, molecular interactions are often classified as strong (long-range), typically driven by ionic contacts and salt bridges, or as weak (short-range), such as hydrophobic interactions. The reality is more complex, with classical strong interactions having weak contributions and vice versa. The interaction network regulating the properties of biomolecular systems such as proteins and their media goes beyond a single sort of contribution, and instead it is characterized by the interplay between several forces of diverse nature. In this review, we discuss, via selected examples, state of the art methodologies and applications of computational techniques to explore the role of intermolecular interactions, with emphasis on solvent effects on protein folding, enzymatic activity, and protein-peptide binding.</p>","PeriodicalId":32,"journal":{"name":"Chemical Reviews","volume":" ","pages":""},"PeriodicalIF":55.8,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144725976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Chemical ReviewsPub Date : 2025-07-28DOI: 10.1021/acs.chemrev.5c00193
Tingting Hu, Yu Yang, Tao Wang, Min Ge, Chaojie Yu, Jiajia Zha, Xiangrong Pan, Zhan Zhou, Lufang Ma, Ruizheng Liang, Chaoliang Tan
{"title":"Structural Engineering of Layered Nanomaterials for Biomedical Applications.","authors":"Tingting Hu, Yu Yang, Tao Wang, Min Ge, Chaojie Yu, Jiajia Zha, Xiangrong Pan, Zhan Zhou, Lufang Ma, Ruizheng Liang, Chaoliang Tan","doi":"10.1021/acs.chemrev.5c00193","DOIUrl":"https://doi.org/10.1021/acs.chemrev.5c00193","url":null,"abstract":"<p><p>Layered nanomaterials have been recognized as promising nanomaterials for biomedical applications due to their tunable crystal phase, easy exfoliation, capability as the host to be intercalated with guest species, and layer-dependent electronic/optoelectronic properties. Recent advances in structural engineering strategies enable manipulating layered nanomaterials at the atomic level, activating and/or optimizing their properties, and overcoming existing limitations for unlocking unprecedented performance in biomedical applications. In this Review, we comprehensively summarize the latest advancements in structural engineering of layered nanomaterials, focusing on their applications in the biomedical field. First, layered nanomaterials explored in the biomedical field enabled by structural engineering are presented based on their composition and structures, followed by highlighting their unique advantages for structural engineering at the atomic level. Then, the structural engineering strategies of layered nanomaterials including crystal phase engineering, defect engineering, heteroatom doping, interlayer engineering, and crystalline-to-amorphous phase engineering are comprehensively discussed, alongside insights on the advanced characterization techniques. Moreover, the transformative potential of structural engineering to optimize the performance of layered nanomaterials for diverse biomedical applications is discussed in depth. Finally, this Review is concluded with perspectives on the key challenges and bottlenecks of structural engineering of layered nanomaterials in the biomedical field, providing potential solutions and outlining future directions.</p>","PeriodicalId":32,"journal":{"name":"Chemical Reviews","volume":" ","pages":""},"PeriodicalIF":55.8,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144725977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"","authors":"Micheline B. Soley*, and , Eric J. Heller, ","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":32,"journal":{"name":"Chemical Reviews","volume":"125 14","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":51.4,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acs.chemrev.4c01014","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144678393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Chemical ReviewsPub Date : 2025-07-23DOI: 10.1021/acs.chemrev.4c00989
Lucia Lombardi,Valentina Del Genio,Fernando Albericio,Daryl R Williams
{"title":"Advances in Peptidomimetics for Next-Generation Therapeutics: Strategies, Modifications, and Applications.","authors":"Lucia Lombardi,Valentina Del Genio,Fernando Albericio,Daryl R Williams","doi":"10.1021/acs.chemrev.4c00989","DOIUrl":"https://doi.org/10.1021/acs.chemrev.4c00989","url":null,"abstract":"Over the past two decades, peptide drug discovery has experienced a remarkable renaissance, with organic chemistry and biotechnology emerging as pivotal tools for developing peptidomimetics that exhibit improved stability, specificity, and bioavailability compared to conventional peptides. This review systematically examines methodologies for modifying peptide backbones to achieve targeted properties, highlighting recent advances facilitated by modern biotechnological innovations for novel molecular transformations. Additionally, the review emphasizes the practical applications of peptides and peptidomimetics, showcasing their successful integration into medicine and pharmacology. This manuscript evaluates achievements and challenges in the field and identifies critical areas for further research. Its overarching aim is to synthesize current knowledge and propose strategic directions for advancing peptide-based therapeutics.","PeriodicalId":32,"journal":{"name":"Chemical Reviews","volume":"667 1","pages":""},"PeriodicalIF":62.1,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144684336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"","authors":"Ziyang Zhang*, and , Kevan M. Shokat, ","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":32,"journal":{"name":"Chemical Reviews","volume":"125 14","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":51.4,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acs.chemrev.5c00246","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144678391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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