Chemical Reviews最新文献

Beyond In Vivo, Pharmaceutical Molecule Production in Cell-Free Systems and the Use of Noncanonical Amino Acids Therein 在体内之外，无细胞系统中的药物分子生产和其中非规范氨基酸的使用

IF 62.1 1区化学

Chemical Reviews Pub Date : 2025-01-22 DOI: 10.1021/acs.chemrev.4c00126

Marco G. Casteleijn, Ulrike Abendroth, Anne Zemella, Ruben Walter, Rashmi Rashmi, Rainer Haag, Stefan Kubick

引用次数: 0

Protein-Based Degraders: From Chemical Biology Tools to Neo-Therapeutics 基于蛋白质的降解剂：从化学生物学工具到新疗法

IF 62.1 1区化学

Chemical Reviews Pub Date : 2025-01-17 DOI: 10.1021/acs.chemrev.4c00595

Lisha Ou, Mekedlawit T. Setegne, Jeandele Elliot, Fangfang Shen, Laura M. K. Dassama

{"title":"Protein-Based Degraders: From Chemical Biology Tools to Neo-Therapeutics","authors":"Lisha Ou, Mekedlawit T. Setegne, Jeandele Elliot, Fangfang Shen, Laura M. K. Dassama","doi":"10.1021/acs.chemrev.4c00595","DOIUrl":"https://doi.org/10.1021/acs.chemrev.4c00595","url":null,"abstract":"The nascent field of targeted protein degradation (TPD) could revolutionize biomedicine due to the ability of degrader molecules to selectively modulate disease-relevant proteins. A key limitation to the broad application of TPD is its dependence on small-molecule ligands to target proteins of interest. This leaves unstructured proteins or those lacking defined cavities for small-molecule binding out of the scope of many TPD technologies. The use of proteins, peptides, and nucleic acids (otherwise known as “biologics”) as the protein-targeting moieties in degraders addresses this limitation. In the following sections, we provide a comprehensive and critical review of studies that have used proteins and peptides to mediate the degradation and hence the functional control of otherwise challenging disease-relevant protein targets. We describe existing platforms for protein/peptide-based ligand identification and the drug delivery systems that might be exploited for the delivery of biologic-based degraders. Throughout the Review, we underscore the successes, challenges, and opportunities of using protein-based degraders as chemical biology tools to spur discoveries, elucidate mechanisms, and act as a new therapeutic modality.","PeriodicalId":32,"journal":{"name":"Chemical Reviews","volume":"6 1","pages":""},"PeriodicalIF":62.1,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142988374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Hydrolysis, Ligand Exchange, and Redox Properties of Vanadium Compounds: Implications of Solution Transformation on Biological, Therapeutic, and Environmental Applications 钒化合物的水解、配体交换和氧化还原性质：溶液转化在生物、治疗和环境应用中的意义

IF 62.1 1区化学

Chemical Reviews Pub Date : 2025-01-16 DOI: 10.1021/acs.chemrev.4c00475

Rupam Dinda, Eugenio Garribba, Daniele Sanna, Debbie C. Crans, João Costa Pessoa

{"title":"Hydrolysis, Ligand Exchange, and Redox Properties of Vanadium Compounds: Implications of Solution Transformation on Biological, Therapeutic, and Environmental Applications","authors":"Rupam Dinda, Eugenio Garribba, Daniele Sanna, Debbie C. Crans, João Costa Pessoa","doi":"10.1021/acs.chemrev.4c00475","DOIUrl":"https://doi.org/10.1021/acs.chemrev.4c00475","url":null,"abstract":"Vanadium is a transition metal with important industrial, technological, biological, and biomedical applications widespread in the environment and in living beings. The different reactions that vanadium compounds (VCs) undergo in the presence of proteins, nucleic acids, lipids and metabolites under mild physiological conditions are reviewed. In the environment vanadium is present naturally or through anthropogenic sources, the latter having an environmental impact caused by the dispersion of VCs in the atmosphere and aquifers. Vanadium has a versatile chemistry with interconvertible oxidation states, variable coordination number and geometry, and ability to form polyoxidovanadates with various nuclearity and structures. If a VC is added to a water-containing environment it can undergo hydrolysis, ligand-exchange, redox, and other types of changes, determined by the conditions and speciation chemistry of vanadium. Importantly, the solution is likely to differ from the VC introduced into the system and varies with concentration. Here, vanadium redox, hydrolytic and ligand-exchange chemical reactions, the influence of pH, concentration, salt, specific solutes, biomolecules, and VCs on the speciation are described. One of our goals with this work is highlight the need for assessment of the VC speciation, so that beneficial or toxic species might be identified and mechanisms of action be elucidated.","PeriodicalId":32,"journal":{"name":"Chemical Reviews","volume":"7 1","pages":""},"PeriodicalIF":62.1,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142988375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Impact of Electric Fields on Processes at Electrode Interfaces 电场对电极界面过程的影响

IF 62.1 1区化学

Chemical Reviews Pub Date : 2025-01-16 DOI: 10.1021/acs.chemrev.4c00487

Zhuoran Long, Jinhui Meng, Lydia R. Weddle, Pablo E. Videla, Jan Paul Menzel, Delmar G. A. Cabral, Jinchan Liu, Tianyin Qiu, Joseph M. Palasz, Dhritiman Bhattacharyya, Clifford P. Kubiak, Victor S. Batista, Tianquan Lian

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Interfacial Catalysis at Atomic Level 原子水平上的界面催化

IF 62.1 1区化学

Chemical Reviews Pub Date : 2025-01-16 DOI: 10.1021/acs.chemrev.4c00618

Mi Peng, Chengyu Li, Zhaohua Wang, Maolin Wang, Qingxin Zhang, Bingjun Xu, Mufan Li, Ding Ma

{"title":"Interfacial Catalysis at Atomic Level","authors":"Mi Peng, Chengyu Li, Zhaohua Wang, Maolin Wang, Qingxin Zhang, Bingjun Xu, Mufan Li, Ding Ma","doi":"10.1021/acs.chemrev.4c00618","DOIUrl":"https://doi.org/10.1021/acs.chemrev.4c00618","url":null,"abstract":"Heterogeneous catalysts are pivotal to the chemical and energy industries, which are central to a multitude of industrial processes. Large-scale industrial catalytic processes rely on special structures at the nano- or atomic level, where reactions proceed on the so-called active sites of heterogeneous catalysts. The complexity of these catalysts and active sites often lies in the interfacial regions where different components in the catalysts come into contact. Recent advances in synthetic methods, characterization technologies, and reaction kinetics studies have provided atomic-scale insights into these critical interfaces. Achieving atomic precision in interfacial engineering allows for the manipulation of electronic profiles, adsorption patterns, and surface motifs, deepening our understanding of reaction mechanisms at the atomic or molecular level. This mechanistic understanding is indispensable not only for fundamental scientific inquiry but also for the design of the next generation of highly efficient industrial catalysts. This review examines the latest developments in atomic-scale interfacial engineering, covering fundamental concepts, catalyst design, mechanistic insights, and characterization techniques, and shares our perspective on the future trajectory of this dynamic research field.","PeriodicalId":32,"journal":{"name":"Chemical Reviews","volume":"27 1","pages":""},"PeriodicalIF":62.1,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142986156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Covalent Template-Directed Synthesis: A Powerful Tool for the Construction of Complex Molecules 共价模板指导合成：构建复杂分子的强大工具

IF 62.1 1区化学

Chemical Reviews Pub Date : 2025-01-13 DOI: 10.1021/acs.chemrev.4c00505

Peter Bolgar, Mohit Dhiman, Diego Núñez-Villanueva, Christopher A. Hunter

引用次数: 0

Synthetic Lipid Biology 合成脂质生物学

IF 62.1 1区化学

Chemical Reviews Pub Date : 2025-01-13 DOI: 10.1021/acs.chemrev.4c00761

Po-Hsun Brian Chen, Xiang-Ling Li, Jeremy M. Baskin

{"title":"Synthetic Lipid Biology","authors":"Po-Hsun Brian Chen, Xiang-Ling Li, Jeremy M. Baskin","doi":"10.1021/acs.chemrev.4c00761","DOIUrl":"https://doi.org/10.1021/acs.chemrev.4c00761","url":null,"abstract":"Cells contain thousands of different lipids. Their rapid and redundant metabolism, dynamic movement, and many interactions with other biomolecules have justly earned lipids a reputation as a vexing class of molecules to understand. Further, as the cell’s hydrophobic metabolites, lipids assemble into supramolecular structures─most commonly bilayers, or membranes─from which they carry out myriad biological functions. Motivated by this daunting complexity, researchers across disciplines are bringing order to the seeming chaos of biological lipids and membranes. Here, we formalize these efforts as “synthetic lipid biology”. Inspired by the idea, central to synthetic biology, that our abilities to understand and build biological systems are intimately connected, we organize studies and approaches across numerous fields to create, manipulate, and analyze lipids and biomembranes. These include construction of lipids and membranes from scratch using chemical and chemoenzymatic synthesis, editing of pre-existing membranes using optogenetics and protein engineering, detection of lipid metabolism and transport using bioorthogonal chemistry, and probing of lipid–protein interactions and membrane biophysical properties. What emerges is a portrait of an incipient field where chemists, biologists, physicists, and engineers work together in proximity─like lipids themselves─to build a clearer description of the properties, behaviors, and functions of lipids and membranes.","PeriodicalId":32,"journal":{"name":"Chemical Reviews","volume":"22 1","pages":""},"PeriodicalIF":62.1,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142975518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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The Carbene Chemistry of N-Sulfonyl Hydrazones: The Past, Present, and Future n -磺酰腙的卡宾化学：过去、现在和未来

IF 62.1 1区化学

Chemical Reviews Pub Date : 2025-01-10 DOI: 10.1021/acs.chemrev.4c00742

Xiaolong Zhang, Paramasivam Sivaguru, Yongzhen Pan, Nan Wang, Wenjie Zhang, Xihe Bi

{"title":"The Carbene Chemistry of N-Sulfonyl Hydrazones: The Past, Present, and Future","authors":"Xiaolong Zhang, Paramasivam Sivaguru, Yongzhen Pan, Nan Wang, Wenjie Zhang, Xihe Bi","doi":"10.1021/acs.chemrev.4c00742","DOIUrl":"https://doi.org/10.1021/acs.chemrev.4c00742","url":null,"abstract":"N-Sulfonyl hydrazones have been extensively used as operationally safe carbene precursors in modern organic synthesis due to their ready availability, facile functionalization, and environmental benignity. Over the past two decades, there has been tremendous progress in the carbene chemistry of N-sulfonyl hydrazones in the presence of transition metal catalysts, under metal-free conditions, or using photocatalysts under photoirradiation conditions. Many carbene transfer reactions of N-sulfonyl hydrazones are unique and cannot be achieved by any alternative methods. The discovery of novel N-sulfonyl hydrazones and the development of highly enantioselective new reactions and skeletal editing reactions represent the notable recent achievements in the carbene chemistry of N-sulfonyl hydrazones. This review describes the overall progress made in the carbene chemistry of N-sulfonyl hydrazones, organized based on reaction types, spotlighting the current state-of-the-art and remaining challenges to be addressed in the future. Special emphasis is devoted to identifying, describing, and comparing the scope and limitations of current methodologies, key mechanistic scenarios, and potential applications in the synthesis of complex molecules.","PeriodicalId":32,"journal":{"name":"Chemical Reviews","volume":"20 1","pages":""},"PeriodicalIF":62.1,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142940650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Targeted Covalent Modification Strategies for Drugging the Undruggable Targets 靶向共价修饰策略治疗不可药物靶标

IF 62.1 1区化学

Chemical Reviews Pub Date : 2025-01-07 DOI: 10.1021/acs.chemrev.4c00745

Tomonori Tamura, Masaharu Kawano, Itaru Hamachi

{"title":"Targeted Covalent Modification Strategies for Drugging the Undruggable Targets","authors":"Tomonori Tamura, Masaharu Kawano, Itaru Hamachi","doi":"10.1021/acs.chemrev.4c00745","DOIUrl":"https://doi.org/10.1021/acs.chemrev.4c00745","url":null,"abstract":"The term “undruggable” refers to proteins or other biological targets that have been historically challenging to target with conventional drugs or therapeutic strategies because of their structural, functional, or dynamic properties. Drugging such undruggable targets is essential to develop new therapies for diseases where current treatment options are limited or nonexistent. Thus, investigating methods to achieve such drugging is an important challenge in medicinal chemistry. Among the numerous methodologies for drug discovery, covalent modification of therapeutic targets has emerged as a transformative strategy. The covalent attachment of diverse functional molecules to targets provides a powerful platform for creating highly potent drugs and chemical tools as well the ability to provide valuable information on the structures and dynamics of undruggable targets. In this review, we summarize recent examples of chemical methods for the covalent modification of proteins and other biomolecules for the development of new therapeutics and to overcome drug discovery challenges and highlight how such methods contribute toward the drugging of undruggable targets. In particular, we focus on the use of covalent chemistry methods for the development of covalent drugs, target identification, drug screening, artificial modulation of post-translational modifications, cancer specific chemotherapies, and nucleic acid-based therapeutics.","PeriodicalId":32,"journal":{"name":"Chemical Reviews","volume":"138 1","pages":""},"PeriodicalIF":62.1,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142935439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Phase Control in Monometallic and Alloy Nanomaterials 单金属和合金纳米材料的相位控制

IF 62.1 1区化学

Chemical Reviews Pub Date : 2025-01-03 DOI: 10.1021/acs.chemrev.4c00368

Kohei Kusada, Hiroshi Kitagawa

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