Chemical Reviews最新文献_第10页

IF 51.4 1区化学

Chemical Reviews Pub Date : 2025-01-16 DOI: 10.1021/acs.chemrev.4c0061810.1021/acs.chemrev.4c00618

Mi Peng, Chengyu Li, Zhaohua Wang, Maolin Wang, Qingxin Zhang, Bingjun Xu*, Mufan Li* and Ding Ma*,

{"title":"Interfacial Catalysis at Atomic Level","authors":"Mi Peng, Chengyu Li, Zhaohua Wang, Maolin Wang, Qingxin Zhang, Bingjun Xu*, Mufan Li* and Ding Ma*, ","doi":"10.1021/acs.chemrev.4c0061810.1021/acs.chemrev.4c00618","DOIUrl":"https://doi.org/10.1021/acs.chemrev.4c00618https://doi.org/10.1021/acs.chemrev.4c00618","url":null,"abstract":"Heterogeneous catalysts are pivotal to the chemical and energy industries, which are central to a multitude of industrial processes. Large-scale industrial catalytic processes rely on special structures at the nano- or atomic level, where reactions proceed on the so-called active sites of heterogeneous catalysts. The complexity of these catalysts and active sites often lies in the interfacial regions where different components in the catalysts come into contact. Recent advances in synthetic methods, characterization technologies, and reaction kinetics studies have provided atomic-scale insights into these critical interfaces. Achieving atomic precision in interfacial engineering allows for the manipulation of electronic profiles, adsorption patterns, and surface motifs, deepening our understanding of reaction mechanisms at the atomic or molecular level. This mechanistic understanding is indispensable not only for fundamental scientific inquiry but also for the design of the next generation of highly efficient industrial catalysts. This review examines the latest developments in atomic-scale interfacial engineering, covering fundamental concepts, catalyst design, mechanistic insights, and characterization techniques, and shares our perspective on the future trajectory of this dynamic research field.","PeriodicalId":32,"journal":{"name":"Chemical Reviews","volume":"125 4","pages":"2371–2439 2371–2439"},"PeriodicalIF":51.4,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143486759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Impact of Electric Fields on Processes at Electrode Interfaces 电场对电极界面过程的影响

IF 62.1 1区化学

Chemical Reviews Pub Date : 2025-01-16 DOI: 10.1021/acs.chemrev.4c00487

Zhuoran Long, Jinhui Meng, Lydia R. Weddle, Pablo E. Videla, Jan Paul Menzel, Delmar G. A. Cabral, Jinchan Liu, Tianyin Qiu, Joseph M. Palasz, Dhritiman Bhattacharyya, Clifford P. Kubiak, Victor S. Batista, Tianquan Lian

引用次数: 0

Interfacial Catalysis at Atomic Level 原子水平上的界面催化

IF 62.1 1区化学

Chemical Reviews Pub Date : 2025-01-16 DOI: 10.1021/acs.chemrev.4c00618

Mi Peng, Chengyu Li, Zhaohua Wang, Maolin Wang, Qingxin Zhang, Bingjun Xu, Mufan Li, Ding Ma

{"title":"Interfacial Catalysis at Atomic Level","authors":"Mi Peng, Chengyu Li, Zhaohua Wang, Maolin Wang, Qingxin Zhang, Bingjun Xu, Mufan Li, Ding Ma","doi":"10.1021/acs.chemrev.4c00618","DOIUrl":"https://doi.org/10.1021/acs.chemrev.4c00618","url":null,"abstract":"Heterogeneous catalysts are pivotal to the chemical and energy industries, which are central to a multitude of industrial processes. Large-scale industrial catalytic processes rely on special structures at the nano- or atomic level, where reactions proceed on the so-called active sites of heterogeneous catalysts. The complexity of these catalysts and active sites often lies in the interfacial regions where different components in the catalysts come into contact. Recent advances in synthetic methods, characterization technologies, and reaction kinetics studies have provided atomic-scale insights into these critical interfaces. Achieving atomic precision in interfacial engineering allows for the manipulation of electronic profiles, adsorption patterns, and surface motifs, deepening our understanding of reaction mechanisms at the atomic or molecular level. This mechanistic understanding is indispensable not only for fundamental scientific inquiry but also for the design of the next generation of highly efficient industrial catalysts. This review examines the latest developments in atomic-scale interfacial engineering, covering fundamental concepts, catalyst design, mechanistic insights, and characterization techniques, and shares our perspective on the future trajectory of this dynamic research field.","PeriodicalId":32,"journal":{"name":"Chemical Reviews","volume":"27 1","pages":""},"PeriodicalIF":62.1,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142986156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Covalent Template-Directed Synthesis: A Powerful Tool for the Construction of Complex Molecules 共价模板指导合成：构建复杂分子的强大工具

IF 62.1 1区化学

Chemical Reviews Pub Date : 2025-01-13 DOI: 10.1021/acs.chemrev.4c00505

Peter Bolgar, Mohit Dhiman, Diego Núñez-Villanueva, Christopher A. Hunter

引用次数: 0

Synthetic Lipid Biology

IF 51.4 1区化学

Chemical Reviews Pub Date : 2025-01-13 DOI: 10.1021/acs.chemrev.4c0076110.1021/acs.chemrev.4c00761

Po-Hsun Brian Chen, Xiang-Ling Li and Jeremy M. Baskin*,

{"title":"Synthetic Lipid Biology","authors":"Po-Hsun Brian Chen, Xiang-Ling Li and Jeremy M. Baskin*, ","doi":"10.1021/acs.chemrev.4c0076110.1021/acs.chemrev.4c00761","DOIUrl":"https://doi.org/10.1021/acs.chemrev.4c00761https://doi.org/10.1021/acs.chemrev.4c00761","url":null,"abstract":"Cells contain thousands of different lipids. Their rapid and redundant metabolism, dynamic movement, and many interactions with other biomolecules have justly earned lipids a reputation as a vexing class of molecules to understand. Further, as the cell’s hydrophobic metabolites, lipids assemble into supramolecular structures─most commonly bilayers, or membranes─from which they carry out myriad biological functions. Motivated by this daunting complexity, researchers across disciplines are bringing order to the seeming chaos of biological lipids and membranes. Here, we formalize these efforts as “synthetic lipid biology”. Inspired by the idea, central to synthetic biology, that our abilities to understand and build biological systems are intimately connected, we organize studies and approaches across numerous fields to create, manipulate, and analyze lipids and biomembranes. These include construction of lipids and membranes from scratch using chemical and chemoenzymatic synthesis, editing of pre-existing membranes using optogenetics and protein engineering, detection of lipid metabolism and transport using bioorthogonal chemistry, and probing of lipid–protein interactions and membrane biophysical properties. What emerges is a portrait of an incipient field where chemists, biologists, physicists, and engineers work together in proximity─like lipids themselves─to build a clearer description of the properties, behaviors, and functions of lipids and membranes.","PeriodicalId":32,"journal":{"name":"Chemical Reviews","volume":"125 4","pages":"2502–2560 2502–2560"},"PeriodicalIF":51.4,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143487024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthetic Lipid Biology 合成脂质生物学

IF 62.1 1区化学

Chemical Reviews Pub Date : 2025-01-13 DOI: 10.1021/acs.chemrev.4c00761

Po-Hsun Brian Chen, Xiang-Ling Li, Jeremy M. Baskin

{"title":"Synthetic Lipid Biology","authors":"Po-Hsun Brian Chen, Xiang-Ling Li, Jeremy M. Baskin","doi":"10.1021/acs.chemrev.4c00761","DOIUrl":"https://doi.org/10.1021/acs.chemrev.4c00761","url":null,"abstract":"Cells contain thousands of different lipids. Their rapid and redundant metabolism, dynamic movement, and many interactions with other biomolecules have justly earned lipids a reputation as a vexing class of molecules to understand. Further, as the cell’s hydrophobic metabolites, lipids assemble into supramolecular structures─most commonly bilayers, or membranes─from which they carry out myriad biological functions. Motivated by this daunting complexity, researchers across disciplines are bringing order to the seeming chaos of biological lipids and membranes. Here, we formalize these efforts as “synthetic lipid biology”. Inspired by the idea, central to synthetic biology, that our abilities to understand and build biological systems are intimately connected, we organize studies and approaches across numerous fields to create, manipulate, and analyze lipids and biomembranes. These include construction of lipids and membranes from scratch using chemical and chemoenzymatic synthesis, editing of pre-existing membranes using optogenetics and protein engineering, detection of lipid metabolism and transport using bioorthogonal chemistry, and probing of lipid–protein interactions and membrane biophysical properties. What emerges is a portrait of an incipient field where chemists, biologists, physicists, and engineers work together in proximity─like lipids themselves─to build a clearer description of the properties, behaviors, and functions of lipids and membranes.","PeriodicalId":32,"journal":{"name":"Chemical Reviews","volume":"22 1","pages":""},"PeriodicalIF":62.1,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142975518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Covalent Template-Directed Synthesis: A Powerful Tool for the Construction of Complex Molecules

IF 51.4 1区化学

Chemical Reviews Pub Date : 2025-01-13 DOI: 10.1021/acs.chemrev.4c0050510.1021/acs.chemrev.4c00505

Peter Bolgar, Mohit Dhiman, Diego Núñez-Villanueva* and Christopher A. Hunter*,

引用次数: 0

The Carbene Chemistry of N-Sulfonyl Hydrazones: The Past, Present, and Future n -磺酰腙的卡宾化学：过去、现在和未来

IF 62.1 1区化学

Chemical Reviews Pub Date : 2025-01-10 DOI: 10.1021/acs.chemrev.4c00742

Xiaolong Zhang, Paramasivam Sivaguru, Yongzhen Pan, Nan Wang, Wenjie Zhang, Xihe Bi

{"title":"The Carbene Chemistry of N-Sulfonyl Hydrazones: The Past, Present, and Future","authors":"Xiaolong Zhang, Paramasivam Sivaguru, Yongzhen Pan, Nan Wang, Wenjie Zhang, Xihe Bi","doi":"10.1021/acs.chemrev.4c00742","DOIUrl":"https://doi.org/10.1021/acs.chemrev.4c00742","url":null,"abstract":"N-Sulfonyl hydrazones have been extensively used as operationally safe carbene precursors in modern organic synthesis due to their ready availability, facile functionalization, and environmental benignity. Over the past two decades, there has been tremendous progress in the carbene chemistry of N-sulfonyl hydrazones in the presence of transition metal catalysts, under metal-free conditions, or using photocatalysts under photoirradiation conditions. Many carbene transfer reactions of N-sulfonyl hydrazones are unique and cannot be achieved by any alternative methods. The discovery of novel N-sulfonyl hydrazones and the development of highly enantioselective new reactions and skeletal editing reactions represent the notable recent achievements in the carbene chemistry of N-sulfonyl hydrazones. This review describes the overall progress made in the carbene chemistry of N-sulfonyl hydrazones, organized based on reaction types, spotlighting the current state-of-the-art and remaining challenges to be addressed in the future. Special emphasis is devoted to identifying, describing, and comparing the scope and limitations of current methodologies, key mechanistic scenarios, and potential applications in the synthesis of complex molecules.","PeriodicalId":32,"journal":{"name":"Chemical Reviews","volume":"20 1","pages":""},"PeriodicalIF":62.1,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142940650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Carbene Chemistry of N-Sulfonyl Hydrazones: The Past, Present, and Future

IF 51.4 1区化学

Chemical Reviews Pub Date : 2025-01-10 DOI: 10.1021/acs.chemrev.4c0074210.1021/acs.chemrev.4c00742

Xiaolong Zhang, Paramasivam Sivaguru, Yongzhen Pan, Nan Wang, Wenjie Zhang and Xihe Bi*,

{"title":"The Carbene Chemistry of N-Sulfonyl Hydrazones: The Past, Present, and Future","authors":"Xiaolong Zhang, Paramasivam Sivaguru, Yongzhen Pan, Nan Wang, Wenjie Zhang and Xihe Bi*, ","doi":"10.1021/acs.chemrev.4c0074210.1021/acs.chemrev.4c00742","DOIUrl":"https://doi.org/10.1021/acs.chemrev.4c00742https://doi.org/10.1021/acs.chemrev.4c00742","url":null,"abstract":"N-Sulfonyl hydrazones have been extensively used as operationally safe carbene precursors in modern organic synthesis due to their ready availability, facile functionalization, and environmental benignity. Over the past two decades, there has been tremendous progress in the carbene chemistry of N-sulfonyl hydrazones in the presence of transition metal catalysts, under metal-free conditions, or using photocatalysts under photoirradiation conditions. Many carbene transfer reactions of N-sulfonyl hydrazones are unique and cannot be achieved by any alternative methods. The discovery of novel N-sulfonyl hydrazones and the development of highly enantioselective new reactions and skeletal editing reactions represent the notable recent achievements in the carbene chemistry of N-sulfonyl hydrazones. This review describes the overall progress made in the carbene chemistry of N-sulfonyl hydrazones, organized based on reaction types, spotlighting the current state-of-the-art and remaining challenges to be addressed in the future. Special emphasis is devoted to identifying, describing, and comparing the scope and limitations of current methodologies, key mechanistic scenarios, and potential applications in the synthesis of complex molecules.","PeriodicalId":32,"journal":{"name":"Chemical Reviews","volume":"125 2","pages":"1049–1190 1049–1190"},"PeriodicalIF":51.4,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143087596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Targeted Covalent Modification Strategies for Drugging the Undruggable Targets

IF 51.4 1区化学

Chemical Reviews Pub Date : 2025-01-07 DOI: 10.1021/acs.chemrev.4c0074510.1021/acs.chemrev.4c00745

Tomonori Tamura*, Masaharu Kawano and Itaru Hamachi*,

{"title":"Targeted Covalent Modification Strategies for Drugging the Undruggable Targets","authors":"Tomonori Tamura*, Masaharu Kawano and Itaru Hamachi*, ","doi":"10.1021/acs.chemrev.4c0074510.1021/acs.chemrev.4c00745","DOIUrl":"https://doi.org/10.1021/acs.chemrev.4c00745https://doi.org/10.1021/acs.chemrev.4c00745","url":null,"abstract":"The term “undruggable” refers to proteins or other biological targets that have been historically challenging to target with conventional drugs or therapeutic strategies because of their structural, functional, or dynamic properties. Drugging such undruggable targets is essential to develop new therapies for diseases where current treatment options are limited or nonexistent. Thus, investigating methods to achieve such drugging is an important challenge in medicinal chemistry. Among the numerous methodologies for drug discovery, covalent modification of therapeutic targets has emerged as a transformative strategy. The covalent attachment of diverse functional molecules to targets provides a powerful platform for creating highly potent drugs and chemical tools as well the ability to provide valuable information on the structures and dynamics of undruggable targets. In this review, we summarize recent examples of chemical methods for the covalent modification of proteins and other biomolecules for the development of new therapeutics and to overcome drug discovery challenges and highlight how such methods contribute toward the drugging of undruggable targets. In particular, we focus on the use of covalent chemistry methods for the development of covalent drugs, target identification, drug screening, artificial modulation of post-translational modifications, cancer specific chemotherapies, and nucleic acid-based therapeutics.","PeriodicalId":32,"journal":{"name":"Chemical Reviews","volume":"125 2","pages":"1191–1253 1191–1253"},"PeriodicalIF":51.4,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143090843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0