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Characterizing Electrode Materials and Interfaces in Solid-State Batteries 表征固态电池中的电极材料和界面
IF 62.1 1区 化学
Chemical Reviews Pub Date : 2025-02-04 DOI: 10.1021/acs.chemrev.4c00584
Elif Pınar Alsaç, Douglas Lars Nelson, Sun Geun Yoon, Kelsey Anne Cavallaro, Congcheng Wang, Stephanie Elizabeth Sandoval, Udochukwu D. Eze, Won Joon Jeong, Matthew T. McDowell
{"title":"Characterizing Electrode Materials and Interfaces in Solid-State Batteries","authors":"Elif Pınar Alsaç, Douglas Lars Nelson, Sun Geun Yoon, Kelsey Anne Cavallaro, Congcheng Wang, Stephanie Elizabeth Sandoval, Udochukwu D. Eze, Won Joon Jeong, Matthew T. McDowell","doi":"10.1021/acs.chemrev.4c00584","DOIUrl":"https://doi.org/10.1021/acs.chemrev.4c00584","url":null,"abstract":"Solid-state batteries (SSBs) could offer improved energy density and safety, but the evolution and degradation of electrode materials and interfaces within SSBs are distinct from conventional batteries with liquid electrolytes and represent a barrier to performance improvement. Over the past decade, a variety of imaging, scattering, and spectroscopic characterization methods has been developed or used for characterizing the unique aspects of materials in SSBs. These characterization efforts have yielded new understanding of the behavior of lithium metal anodes, alloy anodes, composite cathodes, and the interfaces of these various electrode materials with solid-state electrolytes (SSEs). This review provides a comprehensive overview of the characterization methods and strategies applied to SSBs, and it presents the mechanistic understanding of SSB materials and interfaces that has been derived from these methods. This knowledge has been critical for advancing SSB technology and will continue to guide the engineering of materials and interfaces toward practical performance.","PeriodicalId":32,"journal":{"name":"Chemical Reviews","volume":"132 1","pages":""},"PeriodicalIF":62.1,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143083474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Quantum Algorithms and Applications for Open Quantum Systems
IF 62.1 1区 化学
Chemical Reviews Pub Date : 2025-02-04 DOI: 10.1021/acs.chemrev.4c00428
Luis H. Delgado-Granados, Timothy J. Krogmeier, LeeAnn M. Sager-Smith, Irma Avdic, Zixuan Hu, Manas Sajjan, Maryam Abbasi, Scott E. Smart, Prineha Narang, Sabre Kais, Anthony W. Schlimgen, Kade Head-Marsden, David A. Mazziotti
{"title":"Quantum Algorithms and Applications for Open Quantum Systems","authors":"Luis H. Delgado-Granados, Timothy J. Krogmeier, LeeAnn M. Sager-Smith, Irma Avdic, Zixuan Hu, Manas Sajjan, Maryam Abbasi, Scott E. Smart, Prineha Narang, Sabre Kais, Anthony W. Schlimgen, Kade Head-Marsden, David A. Mazziotti","doi":"10.1021/acs.chemrev.4c00428","DOIUrl":"https://doi.org/10.1021/acs.chemrev.4c00428","url":null,"abstract":"Accurate models for open quantum systems─quantum states that have nontrivial interactions with their environment─may aid in the advancement of a diverse array of fields, including quantum computation, informatics, and the prediction of static and dynamic molecular properties. In recent years, quantum algorithms have been leveraged for the computation of open quantum systems as the predicted quantum advantage of quantum devices over classical ones may allow previously inaccessible applications. Accomplishing this goal will require input and expertise from different research perspectives, as well as the training of a diverse quantum workforce, making a compilation of current quantum methods for treating open quantum systems both useful and timely. In this Review, we first provide a succinct summary of the fundamental theory of open quantum systems and then delve into a discussion on recent quantum algorithms. We conclude with a discussion of pertinent applications, demonstrating the applicability of this field to realistic chemical, biological, and material systems.","PeriodicalId":32,"journal":{"name":"Chemical Reviews","volume":"43 1","pages":""},"PeriodicalIF":62.1,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143124919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In Situ TEM Characterization of Battery Materials
IF 51.4 1区 化学
Chemical Reviews Pub Date : 2025-02-04 DOI: 10.1021/acs.chemrev.4c0050710.1021/acs.chemrev.4c00507
Diyi Cheng, Jinseok Hong, Daewon Lee, Seung-Yong Lee* and Haimei Zheng*, 
{"title":"In Situ TEM Characterization of Battery Materials","authors":"Diyi Cheng,&nbsp;Jinseok Hong,&nbsp;Daewon Lee,&nbsp;Seung-Yong Lee* and Haimei Zheng*,&nbsp;","doi":"10.1021/acs.chemrev.4c0050710.1021/acs.chemrev.4c00507","DOIUrl":"https://doi.org/10.1021/acs.chemrev.4c00507https://doi.org/10.1021/acs.chemrev.4c00507","url":null,"abstract":"<p >Transmission electron microscopy (TEM) is an indispensable analytical technique in materials research as it probes material information down to the atomic level and can be utilized to examine dynamic phenomena during material transformations. <i>In situ</i> TEM resolves transient metastable states via direct observation of material dynamics under external stimuli. With innovative sample designs developed over the past decades, advanced <i>in situ</i> TEM has enabled emulation of battery operation conditions to unveil nanoscale changes within electrodes, at interfaces, and in electrolytes, rendering it a unique tool to offer unequivocal insights of battery materials that are beam-sensitive, air-sensitive, or that contain light elements, etc. In this review, we first briefly outline the history of advanced electron microscopy along with battery research, followed by an introduction to various <i>in situ</i> TEM sample cell configurations. We provide a comprehensive review on <i>in situ</i> TEM studies of battery materials for lithium batteries and beyond (e.g., sodium batteries and other battery chemistries) via open-cell and closed-cell <i>in situ</i> TEM approaches. At the end, we raise several unresolved points regarding sample preparation protocol, imaging conditions, etc., for <i>in situ</i> TEM experiments. We also provide an outlook on the next-stage development of <i>in situ</i> TEM for battery material study, aiming to foster closer collaboration between <i>in situ</i> TEM and battery research communities for mutual progress.</p>","PeriodicalId":32,"journal":{"name":"Chemical Reviews","volume":"125 4","pages":"1840–1896 1840–1896"},"PeriodicalIF":51.4,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143486931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Proton Exchange Membrane (PEM) Water Electrolysis: Cell-Level Considerations for Gigawatt-Scale Deployment 质子交换膜 (PEM) 水电解:千兆瓦级部署的细胞级考虑因素
IF 62.1 1区 化学
Chemical Reviews Pub Date : 2025-02-03 DOI: 10.1021/acs.chemrev.3c00904
Cliffton Ray Wang, John M. Stansberry, Rangachary Mukundan, Hung-Ming Joseph Chang, Devashish Kulkarni, Andrew M. Park, Austin B. Plymill, Nausir Mahmoud Firas, Christopher Pantayatiwong Liu, Jack T. Lang, Jason Keonhag Lee, Nadia E. Tolouei, Yu Morimoto, CH Wang, Gaohua Zhu, Jack Brouwer, Plamen Atanassov, Christopher B. Capuano, Cortney Mittelsteadt, Xiong Peng, Iryna V. Zenyuk
{"title":"Proton Exchange Membrane (PEM) Water Electrolysis: Cell-Level Considerations for Gigawatt-Scale Deployment","authors":"Cliffton Ray Wang, John M. Stansberry, Rangachary Mukundan, Hung-Ming Joseph Chang, Devashish Kulkarni, Andrew M. Park, Austin B. Plymill, Nausir Mahmoud Firas, Christopher Pantayatiwong Liu, Jack T. Lang, Jason Keonhag Lee, Nadia E. Tolouei, Yu Morimoto, CH Wang, Gaohua Zhu, Jack Brouwer, Plamen Atanassov, Christopher B. Capuano, Cortney Mittelsteadt, Xiong Peng, Iryna V. Zenyuk","doi":"10.1021/acs.chemrev.3c00904","DOIUrl":"https://doi.org/10.1021/acs.chemrev.3c00904","url":null,"abstract":"Hydrogen produced with no greenhouse gas emissions is termed “green hydrogen” and will be essential to reaching decarbonization targets set forth by nearly every country as per the Paris Agreement. Proton exchange membrane water electrolyzers (PEMWEs) are expected to contribute substantially to the green hydrogen market. However, PEMWE market penetration is insignificant, accounting for less than a gigawatt of global capacity. Achieving substantive decarbonization via green hydrogen will require PEMWEs to reach capacities of hundreds of gigawatts by 2030. This paper serves as an overarching roadmap for cell-level improvements necessary for gigawatt-scale PEMWE deployment, with insights from three well-established hydrogen technology companies included. Analyses will be presented for economies of scale, renewable energy prices, government policies, accelerated stress tests, and component-specific improvements.","PeriodicalId":32,"journal":{"name":"Chemical Reviews","volume":"38 1","pages":""},"PeriodicalIF":62.1,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143077371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Proton Exchange Membrane (PEM) Water Electrolysis: Cell-Level Considerations for Gigawatt-Scale Deployment
IF 51.4 1区 化学
Chemical Reviews Pub Date : 2025-02-03 DOI: 10.1021/acs.chemrev.3c0090410.1021/acs.chemrev.3c00904
Cliffton Ray Wang, John M. Stansberry, Rangachary Mukundan, Hung-Ming Joseph Chang, Devashish Kulkarni, Andrew M. Park, Austin B. Plymill, Nausir Mahmoud Firas, Christopher Pantayatiwong Liu, Jack T. Lang, Jason Keonhag Lee, Nadia E. Tolouei, Yu Morimoto, CH Wang, Gaohua Zhu, Jack Brouwer, Plamen Atanassov, Christopher B. Capuano, Cortney Mittelsteadt, Xiong Peng and Iryna V. Zenyuk*, 
{"title":"Proton Exchange Membrane (PEM) Water Electrolysis: Cell-Level Considerations for Gigawatt-Scale Deployment","authors":"Cliffton Ray Wang,&nbsp;John M. Stansberry,&nbsp;Rangachary Mukundan,&nbsp;Hung-Ming Joseph Chang,&nbsp;Devashish Kulkarni,&nbsp;Andrew M. Park,&nbsp;Austin B. Plymill,&nbsp;Nausir Mahmoud Firas,&nbsp;Christopher Pantayatiwong Liu,&nbsp;Jack T. Lang,&nbsp;Jason Keonhag Lee,&nbsp;Nadia E. Tolouei,&nbsp;Yu Morimoto,&nbsp;CH Wang,&nbsp;Gaohua Zhu,&nbsp;Jack Brouwer,&nbsp;Plamen Atanassov,&nbsp;Christopher B. Capuano,&nbsp;Cortney Mittelsteadt,&nbsp;Xiong Peng and Iryna V. Zenyuk*,&nbsp;","doi":"10.1021/acs.chemrev.3c0090410.1021/acs.chemrev.3c00904","DOIUrl":"https://doi.org/10.1021/acs.chemrev.3c00904https://doi.org/10.1021/acs.chemrev.3c00904","url":null,"abstract":"<p >Hydrogen produced with no greenhouse gas emissions is termed “green hydrogen” and will be essential to reaching decarbonization targets set forth by nearly every country as per the Paris Agreement. Proton exchange membrane water electrolyzers (PEMWEs) are expected to contribute substantially to the green hydrogen market. However, PEMWE market penetration is insignificant, accounting for less than a gigawatt of global capacity. Achieving substantive decarbonization via green hydrogen will require PEMWEs to reach capacities of hundreds of gigawatts by 2030. This paper serves as an overarching roadmap for cell-level improvements necessary for gigawatt-scale PEMWE deployment, with insights from three well-established hydrogen technology companies included. Analyses will be presented for economies of scale, renewable energy prices, government policies, accelerated stress tests, and component-specific improvements.</p>","PeriodicalId":32,"journal":{"name":"Chemical Reviews","volume":"125 3","pages":"1257–1302 1257–1302"},"PeriodicalIF":51.4,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acs.chemrev.3c00904","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143385916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Electrocatalysis: From Planar Surfaces to Nanostructured Interfaces 电催化:从平面表面到纳米结构界面
IF 62.1 1区 化学
Chemical Reviews Pub Date : 2025-01-28 DOI: 10.1021/acs.chemrev.4c00133
Alasdair R. Fairhurst, Joshua Snyder, Chao Wang, Dusan Strmcnik, Vojislav R. Stamenkovic
{"title":"Electrocatalysis: From Planar Surfaces to Nanostructured Interfaces","authors":"Alasdair R. Fairhurst, Joshua Snyder, Chao Wang, Dusan Strmcnik, Vojislav R. Stamenkovic","doi":"10.1021/acs.chemrev.4c00133","DOIUrl":"https://doi.org/10.1021/acs.chemrev.4c00133","url":null,"abstract":"The reactions critical for the energy transition center on the chemistry of hydrogen, oxygen, carbon, and the heterogeneous catalyst surfaces that make up electrochemical energy conversion systems. Together, the surface–adsorbate interactions constitute the electrochemical interphase and define reaction kinetics of many clean energy technologies. Practical devices introduce high levels of complexity where surface roughness, structure, composition, and morphology combine with electrolyte, pH, diffusion, and system level limitations to challenge our ability to deconvolute underlying phenomena. To make significant strides in materials design, a structured approach based on well-defined surfaces is necessary to selectively control distinct parameters, while complexity is added sequentially through careful application of nanostructured surfaces. In this review, we cover advances made through this approach for key elements in the field, beginning with the simplest hydrogen oxidation and evolution reactions and concluding with more complex organic molecules. In each case, we offer a unique perspective on the contribution of well-defined systems to our understanding of electrochemical energy conversion technologies and how wider deployment can aid intelligent materials design.","PeriodicalId":32,"journal":{"name":"Chemical Reviews","volume":"36 1","pages":""},"PeriodicalIF":62.1,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143050646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Electrocatalysis: From Planar Surfaces to Nanostructured Interfaces
IF 51.4 1区 化学
Chemical Reviews Pub Date : 2025-01-28 DOI: 10.1021/acs.chemrev.4c0013310.1021/acs.chemrev.4c00133
Alasdair R. Fairhurst, Joshua Snyder, Chao Wang, Dusan Strmcnik and Vojislav R. Stamenkovic*, 
{"title":"Electrocatalysis: From Planar Surfaces to Nanostructured Interfaces","authors":"Alasdair R. Fairhurst,&nbsp;Joshua Snyder,&nbsp;Chao Wang,&nbsp;Dusan Strmcnik and Vojislav R. Stamenkovic*,&nbsp;","doi":"10.1021/acs.chemrev.4c0013310.1021/acs.chemrev.4c00133","DOIUrl":"https://doi.org/10.1021/acs.chemrev.4c00133https://doi.org/10.1021/acs.chemrev.4c00133","url":null,"abstract":"<p >The reactions critical for the energy transition center on the chemistry of hydrogen, oxygen, carbon, and the heterogeneous catalyst surfaces that make up electrochemical energy conversion systems. Together, the surface–adsorbate interactions constitute the electrochemical interphase and define reaction kinetics of many clean energy technologies. Practical devices introduce high levels of complexity where surface roughness, structure, composition, and morphology combine with electrolyte, pH, diffusion, and system level limitations to challenge our ability to deconvolute underlying phenomena. To make significant strides in materials design, a structured approach based on well-defined surfaces is necessary to selectively control distinct parameters, while complexity is added sequentially through careful application of nanostructured surfaces. In this review, we cover advances made through this approach for key elements in the field, beginning with the simplest hydrogen oxidation and evolution reactions and concluding with more complex organic molecules. In each case, we offer a unique perspective on the contribution of well-defined systems to our understanding of electrochemical energy conversion technologies and how wider deployment can aid intelligent materials design.</p>","PeriodicalId":32,"journal":{"name":"Chemical Reviews","volume":"125 3","pages":"1332–1419 1332–1419"},"PeriodicalIF":51.4,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acs.chemrev.4c00133","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143386061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rational Design of Nanozymes for Engineered Cascade Catalytic Cancer Therapy 合理设计用于工程级联催化癌症疗法的纳米酶
IF 62.1 1区 化学
Chemical Reviews Pub Date : 2025-01-27 DOI: 10.1021/acs.chemrev.4c00882
Xiuna Jia, Erkang Wang, Jin Wang
{"title":"Rational Design of Nanozymes for Engineered Cascade Catalytic Cancer Therapy","authors":"Xiuna Jia, Erkang Wang, Jin Wang","doi":"10.1021/acs.chemrev.4c00882","DOIUrl":"https://doi.org/10.1021/acs.chemrev.4c00882","url":null,"abstract":"Nanozymes have shown significant potential in cancer catalytic therapy by strategically catalyzing tumor-associated substances and metabolites into toxic reactive oxygen species (ROS) <i>in situ</i>, thereby inducing oxidative stress and promoting cancer cell death. However, within the complex tumor microenvironment (TME), the rational design of nanozymes and factors like activity, reaction substrates, and the TME itself significantly influence the efficiency of ROS generation. To address these limitations, recent research has focused on exploring the factors that affect activity and developing nanozyme-based cascade catalytic systems, which can trigger two or more cascade catalytic processes within tumors, thereby producing more therapeutic substances and achieving efficient and stable cancer therapy with minimal side effects. This area has shown remarkable progress. This Perspective provides a comprehensive overview of nanozymes, covering their classification and fundamentals. The regulation of nanozyme activity and efficient strategies of rational design are discussed in detail. Furthermore, representative paradigms for the successful construction of cascade catalytic systems for cancer treatment are summarized with a focus on revealing the underlying catalytic mechanisms. Finally, we address the current challenges and future prospects for the development of nanozyme-based cascade catalytic systems in biomedical applications.","PeriodicalId":32,"journal":{"name":"Chemical Reviews","volume":"28 1","pages":""},"PeriodicalIF":62.1,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143050647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rational Design of Nanozymes for Engineered Cascade Catalytic Cancer Therapy
IF 51.4 1区 化学
Chemical Reviews Pub Date : 2025-01-27 DOI: 10.1021/acs.chemrev.4c0088210.1021/acs.chemrev.4c00882
Xiuna Jia, Erkang Wang and Jin Wang*, 
{"title":"Rational Design of Nanozymes for Engineered Cascade Catalytic Cancer Therapy","authors":"Xiuna Jia,&nbsp;Erkang Wang and Jin Wang*,&nbsp;","doi":"10.1021/acs.chemrev.4c0088210.1021/acs.chemrev.4c00882","DOIUrl":"https://doi.org/10.1021/acs.chemrev.4c00882https://doi.org/10.1021/acs.chemrev.4c00882","url":null,"abstract":"<p >Nanozymes have shown significant potential in cancer catalytic therapy by strategically catalyzing tumor-associated substances and metabolites into toxic reactive oxygen species (ROS) <i>in situ</i>, thereby inducing oxidative stress and promoting cancer cell death. However, within the complex tumor microenvironment (TME), the rational design of nanozymes and factors like activity, reaction substrates, and the TME itself significantly influence the efficiency of ROS generation. To address these limitations, recent research has focused on exploring the factors that affect activity and developing nanozyme-based cascade catalytic systems, which can trigger two or more cascade catalytic processes within tumors, thereby producing more therapeutic substances and achieving efficient and stable cancer therapy with minimal side effects. This area has shown remarkable progress. This Perspective provides a comprehensive overview of nanozymes, covering their classification and fundamentals. The regulation of nanozyme activity and efficient strategies of rational design are discussed in detail. Furthermore, representative paradigms for the successful construction of cascade catalytic systems for cancer treatment are summarized with a focus on revealing the underlying catalytic mechanisms. Finally, we address the current challenges and future prospects for the development of nanozyme-based cascade catalytic systems in biomedical applications.</p>","PeriodicalId":32,"journal":{"name":"Chemical Reviews","volume":"125 5","pages":"2908–2952 2908–2952"},"PeriodicalIF":51.4,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143591333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Beyond In Vivo, Pharmaceutical Molecule Production in Cell-Free Systems and the Use of Noncanonical Amino Acids Therein
IF 51.4 1区 化学
Chemical Reviews Pub Date : 2025-01-22 DOI: 10.1021/acs.chemrev.4c0012610.1021/acs.chemrev.4c00126
Marco G. Casteleijn*, Ulrike Abendroth, Anne Zemella, Ruben Walter, Rashmi Rashmi, Rainer Haag and Stefan Kubick*, 
{"title":"Beyond In Vivo, Pharmaceutical Molecule Production in Cell-Free Systems and the Use of Noncanonical Amino Acids Therein","authors":"Marco G. Casteleijn*,&nbsp;Ulrike Abendroth,&nbsp;Anne Zemella,&nbsp;Ruben Walter,&nbsp;Rashmi Rashmi,&nbsp;Rainer Haag and Stefan Kubick*,&nbsp;","doi":"10.1021/acs.chemrev.4c0012610.1021/acs.chemrev.4c00126","DOIUrl":"https://doi.org/10.1021/acs.chemrev.4c00126https://doi.org/10.1021/acs.chemrev.4c00126","url":null,"abstract":"<p >Throughout history, we have looked to nature to discover and copy pharmaceutical solutions to prevent and heal diseases. Due to the advances in metabolic engineering and the production of pharmaceutical proteins in different host cells, we have moved from mimicking nature to the delicate engineering of cells and proteins. We can now produce novel drug molecules, which are fusions of small chemical drugs and proteins. Currently we are at the brink of yet another step to venture beyond nature’s border with the use of unnatural amino acids and manufacturing without the use of living cells using cell-free systems. In this review, we summarize the progress and limitations of the last decades in the development of pharmaceutical protein development, production in cells, and cell-free systems. We also discuss possible future directions of the field.</p>","PeriodicalId":32,"journal":{"name":"Chemical Reviews","volume":"125 3","pages":"1303–1331 1303–1331"},"PeriodicalIF":51.4,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acs.chemrev.4c00126","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143386115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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