{"title":"ACS Central Science: Embracing Breadth in Scope and Scientific Topical Representation","authors":"Sofia Garakyaraghi, and , Kirk S. Schanze*, ","doi":"10.1021/acscentsci.5c01315","DOIUrl":"https://doi.org/10.1021/acscentsci.5c01315","url":null,"abstract":"","PeriodicalId":10,"journal":{"name":"ACS Central Science","volume":"11 9","pages":"1512–1514"},"PeriodicalIF":10.4,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acscentsci.5c01315","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145117281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Let There Be Light for Photoproximity Labeling","authors":"Tae Young Han, and , Hyun-Woo Rhee, ","doi":"10.1021/acscentsci.5c01587","DOIUrl":"https://doi.org/10.1021/acscentsci.5c01587","url":null,"abstract":"<p >Bioluminescence-assisted photoproximity labeling enables spatial proteome mapping in deep tissues.</p>","PeriodicalId":10,"journal":{"name":"ACS Central Science","volume":"11 9","pages":"1524–1526"},"PeriodicalIF":10.4,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acscentsci.5c01587","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145117299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Conversation with Belén González-Gaya","authors":"XiaoZhi Lim, ","doi":"10.1021/acscentsci.5c01511","DOIUrl":"https://doi.org/10.1021/acscentsci.5c01511","url":null,"abstract":"<p >The environmental scientist hitched a ride on a tourist cruise to measure pollutants in Antarctica.</p>","PeriodicalId":10,"journal":{"name":"ACS Central Science","volume":"11 9","pages":"1515–1517"},"PeriodicalIF":10.4,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acscentsci.5c01511","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145117405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Long-Lost Coffee Bean Tastes as Good as the Best─To Understand Why, Scientists Turn to Chemistry","authors":"Marta Zaraska, ","doi":"10.1021/acscentsci.5c01454","DOIUrl":"https://doi.org/10.1021/acscentsci.5c01454","url":null,"abstract":"<p >The climate-resistant bean boasts a chemical profile similar to Arabica’s.</p>","PeriodicalId":10,"journal":{"name":"ACS Central Science","volume":"11 9","pages":"1521–1523"},"PeriodicalIF":10.4,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acscentsci.5c01454","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145117411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Noemi Jiménez-Rojo, , , Suihan Feng, , , Johannes Morstein*, , , Stefanie D. Pritzl, , , Antonino Asaro, , , Sergio López, , , Yun Xu, , , Takeshi Harayama, , , Nynke A. Vepřek, , , Christopher J. Arp, , , Martin Reynders, , , Alexander J. E. Novak, , , Evgeny Kanshin, , , Jan Lipfert, , , Beatrix Ueberheide, , , Manuel Muñiz, , , Theobald Lohmüller, , , Howard Riezman*, , and , Dirk Trauner*,
{"title":"Optical Control of Membrane Viscosity Modulates ER-to-Golgi Trafficking","authors":"Noemi Jiménez-Rojo, , , Suihan Feng, , , Johannes Morstein*, , , Stefanie D. Pritzl, , , Antonino Asaro, , , Sergio López, , , Yun Xu, , , Takeshi Harayama, , , Nynke A. Vepřek, , , Christopher J. Arp, , , Martin Reynders, , , Alexander J. E. Novak, , , Evgeny Kanshin, , , Jan Lipfert, , , Beatrix Ueberheide, , , Manuel Muñiz, , , Theobald Lohmüller, , , Howard Riezman*, , and , Dirk Trauner*, ","doi":"10.1021/acscentsci.5c00606","DOIUrl":"https://doi.org/10.1021/acscentsci.5c00606","url":null,"abstract":"<p >The lipid composition of cellular membranes is highly dynamic and undergoes continuous remodeling, affecting the biophysical properties critical to biological function. Here, we introduce an optical approach to manipulate membrane viscosity based on an exogenous synthetic fatty acid with an azobenzene photoswitch, termed <b>FAAzo4</b>. Cells rapidly incorporate <b>FAAzo4</b> into phosphatidylcholine and phosphatidylethanolamine in a concentration- and cell type-dependent manner. This generates photoswitchable PC and PE analogs, which are predominantly located in the endoplasmic reticulum. Irradiation causes a rapid photoisomerization that decreases membrane viscosity with high spatiotemporal precision. We use the resulting “PhotoCells” to study the impact of membrane viscosity on ER-to-Golgi transport and demonstrate that this two-step process has distinct membrane viscosity requirements. Our approach provides an unprecedented way of manipulating membrane biophysical properties directly in living cells and opens novel avenues to probe the effects of viscosity in a wide variety of biological processes.</p><p >PhotoCells enable the dynamic control of protein viscosity in living cells. A decrease of membrane viscosity increases the amount of protein recruited at ERES but slows down the transport to Golgi.</p>","PeriodicalId":10,"journal":{"name":"ACS Central Science","volume":"11 9","pages":"1736–1752"},"PeriodicalIF":10.4,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acscentsci.5c00606","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145117243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Artificial Chiral Trinuclear Zn Catalysts: Design, Self-Assembly and Unprecedented Efficiency in Asymmetric Hydroboration of Ketones","authors":"Jingxi He, , , Shuxin Jiang, , , Yu Qiu, , , Yingchao Liu, , , Kuiling Ding*, , and , Xiaoming Wang*, ","doi":"10.1021/acscentsci.5c01067","DOIUrl":"https://doi.org/10.1021/acscentsci.5c01067","url":null,"abstract":"<p >The development of artificial catalysts with efficiency that can rival those of Nature’s enzymes represents one of the foremost yet challenging goals in homogeneous metal catalysis. Inspired by the exceptional performance of metalloenzymes, the design and development of highly efficient bi/multinuclear catalysts via judicious ligand design, by taking advantage of the cooperative action of the proximal catalytic sites, has attracted great attention. Herein, we report the self-assembly of a chiral hexadentate BINOL-dipyox ligand with zinc acetate into a well-defined trinuclear zinc complex, which demonstrated ultrahigh catalytic productivity in the enantioselective hydroboration of ketones with an unprecedented turnover number (TON) of 19,400 at an extremely low catalyst loading (0.005 mol %). Mechanistic investigations reveal that a cooperative Lewis acid activation mode is operating in the catalytic process, hence, underscoring the unique advantages of the trinuclear architecture.</p><p >This work reports the rational design and self-assembly of an artificial chiral trinuclear zinc catalyst, which exhibits exceptional efficiency in enantioselective ketone hydroboration.</p>","PeriodicalId":10,"journal":{"name":"ACS Central Science","volume":"11 9","pages":"1773–1783"},"PeriodicalIF":10.4,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acscentsci.5c01067","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145117244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"An Assessment of Chemical Diversity in Microbial Natural Products","authors":"Roger G. Linington*, ","doi":"10.1021/acscentsci.5c00804","DOIUrl":"https://doi.org/10.1021/acscentsci.5c00804","url":null,"abstract":"<p >Natural products continue to play important roles in biomedical, agricultural and ecological science. Yet despite ongoing advances in “omics” technologies, including genomics, transcriptomics, phenomics and metabolomics, there is still no clear consensus on the scope and scale of chemical diversity in the natural world. The evolution and maturation of chemical databases for natural products offer opportunities to explore this question from a range of different perspectives. This Outlook will use data from the Natural Products Atlas to examine rates of similarity and variation among biosynthetic classes of molecules, to explore how structure can be related to function, and to examine the scope and scale of new scaffold discovery in the current era of natural products science. It presents an examination of known chemical diversity, investigates what this diversity can tell us about potential translational applications, and explores how current knowledge informs what we might expect to discover in future studies.</p><p >Open-source databases inform our understanding of the known landscape of natural products. These analyses can identify themes among known compound classes and highlight new avenues for investigation.</p>","PeriodicalId":10,"journal":{"name":"ACS Central Science","volume":"11 9","pages":"1536–1545"},"PeriodicalIF":10.4,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acscentsci.5c00804","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145117242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"This Striking Blue Made Pigment History. Could Red Be Next?","authors":"Carrie Arnold, ","doi":"10.1021/acscentsci.5c01396","DOIUrl":"https://doi.org/10.1021/acscentsci.5c01396","url":null,"abstract":"<p >Mas Subramanian’s hunt to create red that’s vivid, durable, and safe.</p>","PeriodicalId":10,"journal":{"name":"ACS Central Science","volume":"11 9","pages":"1518–1520"},"PeriodicalIF":10.4,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acscentsci.5c01396","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145117241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Elizabeth A. Recker, , , Xiaofeng Chen, , , Ji-Won Kim, , and , Zachariah A. Page*,
{"title":"One-Vat Multimaterial 3D Printing: The Devil is in the Details","authors":"Elizabeth A. Recker, , , Xiaofeng Chen, , , Ji-Won Kim, , and , Zachariah A. Page*, ","doi":"10.1021/acscentsci.5c00986","DOIUrl":"https://doi.org/10.1021/acscentsci.5c00986","url":null,"abstract":"<p >Nature combines different materials in a single structure to achieve functions that no single material could accomplish alone, an approach that inspires efforts to build synthetic systems with precisely tailored properties. Vat photopolymerization (VPP) enables fast, high-resolution 3D printing, but most printed parts still use only one material. This Outlook highlights emerging strategies for single-vat multimaterial VPP, where light selectively activates different chemical reactions to build complex structures with multiple materials. Key advances will depend on expanding resin chemistry beyond standard acrylates, improving reaction selectivity, and using grayscale and multiwavelength light control to define where and how materials form. Standardized mechanical, thermal, and interface testing methods are essential for ensuring reliable results. With advances in chemistry, optics, and data-driven design, multimaterial VPP could unlock transformative applications in medicine, manufacturing, and aerospace.</p><p >Stimuli-selective resins offer key opportunities for fast, high-resolution multimaterial 3D printing. This Outlook highlights advances needed in chemistry, processing, and characterization.</p>","PeriodicalId":10,"journal":{"name":"ACS Central Science","volume":"11 9","pages":"1527–1535"},"PeriodicalIF":10.4,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acscentsci.5c00986","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145117348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yulia Sergeeva*, , , Sing Yee Yeung, , , Thomas Hix-Janssens, , and , Börje Sellergren*,
{"title":"Gold Nanoparticles with Adaptable Self-Assembled Monolayer Shells Allow Multivalent Inhibition and Sensing of Influenza Virus at Ultralow Concentrations","authors":"Yulia Sergeeva*, , , Sing Yee Yeung, , , Thomas Hix-Janssens, , and , Börje Sellergren*, ","doi":"10.1021/acscentsci.5c00602","DOIUrl":"https://doi.org/10.1021/acscentsci.5c00602","url":null,"abstract":"<p >Multivalent inhibitors that mimic the polysaccharide array on cells represent a new paradigm in the development of antiviral agents and antibiotics. Covalent ligand anchoring limits the affinity and, in turn, potency of these inhibitors with dissociation constants (<i>K</i><sub>d</sub>) commonly found in the micromolar or upper nanomolar range. Addressing this deficiency we here report on easily accessible gold core–shell nanoparticles (rSAM-NPs) featuring adaptable reversible self-assembled monolayer (rSAM)-based shells. The rSAMs are anchored by noncovalent amidinium-carboxylate interactions on gold nanoparticles at slightly alkaline pH resulting in laterally mobile pH-responsive assemblies that are functional at physiological pH. Introducing sialic acid ligands in the shell, we show that the rSAM-NPs strongly interact with the influenza virus surface protein hemagglutinin (limit of detection LoD < 2 nM) and deactivated bird flu virus H5N1 (LoD < 1 HAU) in allantoic liquid. Finally, we show that the rSAM-NPs effectively inhibit the interaction of the virus with red blood cells at concentrations in the low picomolar range. This represents a significant increase in potency with respect to multivalent inhibitors of similar size based on covalently anchored monosaccharides.</p><p >Gold core nanoparticles with adaptable, sialic acid presenting, self-assembled monolayer shells effectively inhibit the interaction between deactivated bird flu virus (H5N1) and red blood cells at low picomolar concentrations.</p>","PeriodicalId":10,"journal":{"name":"ACS Central Science","volume":"11 9","pages":"1659–1669"},"PeriodicalIF":10.4,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acscentsci.5c00602","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145117349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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