ACS Central Science最新文献_第10页

IF 12.7 1区化学

ACS Central Science Pub Date : 2025-04-23

John Bradshaw, Anji Zhang, Babak Mahjour, David E. Graff, Marwin H. S. Segler and Connor W. Coley*,

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IF 12.7 1区化学

ACS Central Science Pub Date : 2025-04-23

Payal Dhar,

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IF 12.7 1区化学

ACS Central Science Pub Date : 2025-04-23

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IF 12.7 1区化学

ACS Central Science Pub Date : 2025-04-23

Jonathan Feakins,

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IF 12.7 1区化学

ACS Central Science Pub Date : 2025-04-23

Zachary J. Oliver, Dylan J. Abrams, Luana Cardinale, Chih-Jung Chen, Gregory L. Beutner, Seb Caille, Benjamin Cohen, Lin Deng, Moiz Diwan, Michael O. Frederick, Kaid Harper, Joel M. Hawkins, Dan Lehnherr, Christine Lucky, Alex Meyer, Seonmyeong Noh, Diego Nunez, Kyle Quasdorf, Jaykumar Teli, Shannon S. Stahl* and Marcel Schreier*,

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Novel Click Coupling Chemistry to Explore Glycan Recognition. 新的键偶联化学探索聚糖识别。

IF 12.7 1区化学

ACS Central Science Pub Date : 2025-04-23 eCollection Date: 2025-05-28 DOI: 10.1021/acscentsci.4c02124

Tianwei Jia, Akul Y Mehta, Catherine A Tilton, Ea Kristine Clarisse Tulin, Lauren E Pepi, Lukas Muerner, Stephan von Gunten, Jamie Heimburg-Molinaro, Sean R Stowell, Richard D Cummings

{"title":"Novel Click Coupling Chemistry to Explore Glycan Recognition.","authors":"Tianwei Jia, Akul Y Mehta, Catherine A Tilton, Ea Kristine Clarisse Tulin, Lauren E Pepi, Lukas Muerner, Stephan von Gunten, Jamie Heimburg-Molinaro, Sean R Stowell, Richard D Cummings","doi":"10.1021/acscentsci.4c02124","DOIUrl":"10.1021/acscentsci.4c02124","url":null,"abstract":"Specific recognition of glycans by proteins is important in many biological processes and immune responses. Here we present a general approach for derivatizing free glycans with a novel linker MTZ (3-(methoxyamino)-propylamine added to a bioorthogonal-functional tetrazine tag) that exploits click chemistry to generate multiple platforms of glycan coupling. This derivatization preserves glycan integrity, is reversible and quantifiable, and incorporates a bioorthogonal tetrazine tag for click coupling. A library of ABO-(H) blood group MTZ-glycans was efficiently conjugated to avidin Luminex beads through a Biotin-PEG11-TCO (trans-cyclooctene) spacer, generating a multiplex array that was reproducibly interrogated in a high-throughput Luminex approach with multiple lectins and antibodies. We also rapidly profiled antiglycan IgG, IgM, and IgA antibodies in multiple, serially diluted human serum samples, revealing unique repertoires of antiglycan responses in each sera. Glycans were efficiently coupled to bovine serum albumin (BSA) at a high density (∼19-24 glycans/BSA) to generate a neoglycoprotein library that was useful in microarray formats that provided results equivalent to those obtained from the Luminex approach. Neoglycoproteins have many uses, including serving as acceptors for glycosyltransferases, as we demonstrate for assays of ST6Gal1 sialyltransferase. These facile and efficient technologies significantly expand the toolbox available to explore glycan-GBP interactions.","PeriodicalId":10,"journal":{"name":"ACS Central Science","volume":"11 5","pages":"753-769"},"PeriodicalIF":12.7,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12123462/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144197695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Unexpected Damage on Metal Artifacts Triggered by the Hazardous Interfacial Interaction from Aging of Polymer Coatings. 聚合物涂层老化引起的有害界面相互作用对金属工件的意外损伤。

IF 12.7 1区化学

ACS Central Science Pub Date : 2025-04-23 eCollection Date: 2025-05-28 DOI: 10.1021/acscentsci.5c00067

Ying An, Pei Hu, Kaitao Li, Yu Kang, Gang Hu, Rui Tian, Chao Lu, Xue Duan

{"title":"Unexpected Damage on Metal Artifacts Triggered by the Hazardous Interfacial Interaction from Aging of Polymer Coatings.","authors":"Ying An, Pei Hu, Kaitao Li, Yu Kang, Gang Hu, Rui Tian, Chao Lu, Xue Duan","doi":"10.1021/acscentsci.5c00067","DOIUrl":"10.1021/acscentsci.5c00067","url":null,"abstract":"Polymer coatings are currently being employed for preservation of metal artifacts. However, there is insufficient awareness that inevitable aging of polymer coatings is bound to damage metal artifacts due to the lack of a direct and sensitive methodology to study the aging behaviors of polymers coated on the artifacts. Herein, we have developed an in situ and three-dimensional strategy to visualize the early stage aging behaviors of polymers coated on metal artifacts by lighting carboxyl groups generated from polymer aging. It is disclosed that polymer aging occurred simultaneously at the surface and the interface with metal artifacts, generating carboxyl groups and hydroxyl radicals to induce the corrosion and oxidation of metallic artifacts. In turn, the generated metallic ions could further aggravate the aging of polymer coatings, manifested as the larger volume of the aged sites at the interface with metal artifacts in comparison with that at the surface of polymer coatings. Such a circular reaction is validated using real metal artifact samples. These findings raised a timely alarm for the conservation ability and potential threat of polymer coatings on metal artifacts. It is anticipated that the proposed strategy could provide solid supports for the implementation of advanced conservation strategies for metal artifacts.","PeriodicalId":10,"journal":{"name":"ACS Central Science","volume":"11 5","pages":"694-703"},"PeriodicalIF":12.7,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12123457/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144197700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IF 12.7 1区化学

ACS Central Science Pub Date : 2025-04-23

Imon Mandal, Itai Zakai, Natalia V. Karimova, Mark A. Johnson and R. Benny Gerber*,

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Combustion Resistant Borohydrides and Their Chemical Interactions with Li-Metal Surfaces: An Experimental and Theoretical Study. 耐燃硼氢化物及其与锂金属表面的化学相互作用：实验和理论研究。

IF 12.7 1区化学

ACS Central Science Pub Date : 2025-04-23 eCollection Date: 2025-05-28 DOI: 10.1021/acscentsci.5c00043

Anton W Tomich, Stephen Proctor, Moon Young Yang, Jianjun Chen, Yifan Zhao, Edward Chen, Tridip Das, Boris V Merinov, William A Goddard, Juchen Guo, Vincent Lavallo

{"title":"Combustion Resistant Borohydrides and Their Chemical Interactions with Li-Metal Surfaces: An Experimental and Theoretical Study.","authors":"Anton W Tomich, Stephen Proctor, Moon Young Yang, Jianjun Chen, Yifan Zhao, Edward Chen, Tridip Das, Boris V Merinov, William A Goddard, Juchen Guo, Vincent Lavallo","doi":"10.1021/acscentsci.5c00043","DOIUrl":"10.1021/acscentsci.5c00043","url":null,"abstract":"Borohydrides are important molecular entities for a myriad of applications from organic synthesis to components of functional materials and devices. All borohydrides have been thought to be susceptible to spontaneous ignition when exposed to a flame. Herein we demonstrate that this is not always true by identifying several borohydride rich materials that are resistant to combustion when contacted with a torch. One of these materials is a Li+ salt of a carborane anion that depending on its coordination environment exists as a unique ionic liquid that has a nearly naked Li+ countercation. This has provided us with the first opportunity to spectroscopically probe the interactions of such carborane anions with Li metal in a solvent free environment. We found that this carborane anion is immune to deleterious reduction at Li-metal surfaces, as evidenced by XPS, EDS and SEM analysis of the Li-Metal surface after exposure to the ionic liquid. Additionally, NMR analysis of the ionic liquid after stirring it with Li powder shows no reaction. Calculations show that the cage skeleton is reduced at the surface monolayer, but as the reduced form is removed from contact with Li-metal, the cage reverts to the closo-form, demonstrating reversibility.","PeriodicalId":10,"journal":{"name":"ACS Central Science","volume":"11 5","pages":"734-741"},"PeriodicalIF":12.7,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12164935/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144300531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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IF 12.7 1区化学

ACS Central Science Pub Date : 2025-04-23

Pau Nadal Rodríguez, Frederick Hartung, Marina Pedrola, Seemon Coomar, Alejandro Diaz-Moreno, Anna M. Hätälä, Katharina M. Rolfes, Ismael Sánchez-Vera, Joan Gil, Elies Molins, Antonio Viayna, Alexander Hanzl, Nicolas H. Thomä, Thomas Haarmann-Stemmann*, F. Javier Luque*, Rodolfo Lavilla* and Ouldouz Ghashghaei*,

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