ACS Central Science最新文献_第10页

Remediating Biotoxicity with Synthetic Receptors 利用合成受体修复生物毒性

IF 10.4 1区化学

ACS Central Science Pub Date : 2026-05-27 Epub Date: 2026-05-11 DOI: 10.1021/acscentsci.6c00706

Richard J. Hooley,

引用次数: 0

Galactosylated GAG from a Snail Leads to Better Clot Buster 蜗牛半乳糖化的GAG导致更好的凝块清除

IF 10.4 1区化学

ACS Central Science Pub Date : 2026-05-27 Epub Date: 2026-05-12 DOI: 10.1021/acscentsci.6c00639

Ramiz Demir, and , Lara K. Mahal,

引用次数: 0

Single-Crystalline, Semiconductive Layered Organic Cathode Powers High-Energy All-Solid-State Batteries 单晶半导电层状有机阴极为高能全固态电池提供动力

IF 10.4 1区化学

ACS Central Science Pub Date : 2026-05-27 Epub Date: 2026-05-06 DOI: 10.1021/acscentsci.6c00267

Junyong Mo, , , Jiande Wang, , and , Mircea Dincă*,

{"title":"Single-Crystalline, Semiconductive Layered Organic Cathode Powers High-Energy All-Solid-State Batteries","authors":"Junyong Mo, , , Jiande Wang, , and , Mircea Dincă*, ","doi":"10.1021/acscentsci.6c00267","DOIUrl":"https://doi.org/10.1021/acscentsci.6c00267","url":null,"abstract":"All-solid-state batteries (ASSBs) offer a pathway to improved safety and increased energy density but remain limited by sluggish ion transport and low active material loading in composite cathodes. Organic cathode materials provide a sustainable alternative to metal-based systems, yet their implementation in solid-state architectures is constrained by poor electronic conductivity and inefficient electrode microstructures. Here, we integrate a high-capacity, semiconductive, single-crystalline layered organic cathode into ASSBs and demonstrate an electrochemical performance comparable to that of conventional systems. Systematic optimization of cathode composition identifies a configuration that delivers a specific capacity of 310 mAh g–1 at 25 mA g–1 with stable cycling over 100 cycles at room temperature under moderate pressure. At this rate, the architecture achieves an active-material-level energy density of 638 Wh kg–1. Performance limitations are mitigated through compositing with single-walled carbon nanotubes and operation at an elevated temperature. Electrochemical impedance spectroscopy indicates simplified interfacial behavior and suppressed side reactions relative to conventional solid-state cathodes, while in situ measurements reveal volcano-shaped lithium-ion diffusion behavior arising from the interplay between structural evolution and site occupancy. These results define design constraints for organic solid-state cathodes and establish their viability as functional components in next-generation solid-state energy storage.","PeriodicalId":10,"journal":{"name":"ACS Central Science","volume":"12 5","pages":"695–703"},"PeriodicalIF":10.4,"publicationDate":"2026-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acscentsci.6c00267","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148010678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In Situ Kinetics of Solution-Phase Biomolecular Reactions and Interactions through Single-Molecule Displacement Statistics 通过单分子位移统计的溶液相生物分子反应和相互作用的原位动力学

IF 10.4 1区化学

ACS Central Science Pub Date : 2026-05-27 Epub Date: 2026-05-05 DOI: 10.1021/acscentsci.6c00063

Wan Li, and , Ke Xu*,

{"title":"In Situ Kinetics of Solution-Phase Biomolecular Reactions and Interactions through Single-Molecule Displacement Statistics","authors":"Wan Li,  and , Ke Xu*, ","doi":"10.1021/acscentsci.6c00063","DOIUrl":"https://doi.org/10.1021/acscentsci.6c00063","url":null,"abstract":"We report a framework for quantifying the in situ reaction kinetics of bio(macro)molecules in the solution phase through single-molecule displacement statistics. Using single-molecule displacement/diffusivity mapping (SMdM), we measure the transient (0.6 ms) displacements of freely diffusing molecules in the wide field at ultrahigh throughput. Fitting the time-dependent displacement distributions of many molecules to a two-component diffusion model quantifies the reactant and product fractions based on molecular-weight differences, thereby enabling kinetic analysis of reaction progress at ∼1 s temporal resolution. Working with ∼100 pM fluorescently tagged reactant while varying the concentration of a second, unlabeled reactant over wide ranges, we determine second-order reaction rate constants for strain-promoted azide–alkyne cycloaddition and N-hydroxysuccinimide ester aminolysis as well as first-order hydrolysis side-reaction rate constants for the latter. For antibody binding kinetics, we quantify association and dissociation rate constants for a monoclonal antibody and unveil the gradual formation of cross-linked complexes/aggregates for a polyclonal antibody. Working with microliter-scale samples, our single-molecule-displacement-based approach provides intuitive readouts linked to the molecular size and is applicable to diverse reaction types and conditions.","PeriodicalId":10,"journal":{"name":"ACS Central Science","volume":"12 5","pages":"712–718"},"PeriodicalIF":10.4,"publicationDate":"2026-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acscentsci.6c00063","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148010759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Common Photoproperties of Eumelanin and Natural Organic Matter Emerge from Ensembles of Few-Layered Nanostructures 真黑素和天然有机物质的共同光特性来自于少层纳米结构的集合

IF 10.4 1区化学

ACS Central Science Pub Date : 2026-05-27 Epub Date: 2026-04-16 DOI: 10.1021/acscentsci.5c02304

Meera Madhu, , , Aleksandra Ilina, , , Hang Li, , , Garrett McKay*, , and , Bern Kohler*,

{"title":"Common Photoproperties of Eumelanin and Natural Organic Matter Emerge from Ensembles of Few-Layered Nanostructures","authors":"Meera Madhu, , , Aleksandra Ilina, , , Hang Li, , , Garrett McKay*, , and , Bern Kohler*, ","doi":"10.1021/acscentsci.5c02304","DOIUrl":"https://doi.org/10.1021/acscentsci.5c02304","url":null,"abstract":"Carbon-based nanomaterials play central roles in both natural systems and emerging sustainable technologies, serving diverse functions from photoprotection in living organisms to energy harvesting and storage. Eumelanin, the brown-black melanin pigment, and natural organic matter (NOM), a similarly colored substance formed from the decomposition of biological material, represent two of the most widespread yet structurally elusive carbon-based materials in nature. Here, we present a detailed steady-state and time-resolved spectroscopic study, which reveals deep similarities in their photophysical properties as a consequence of common structural motifs at the nanoscale. While eumelanin and NOM have been traditionally studied independently and interpreted using molecular models, we introduce a framework centered on interchromophoric couplings to explain how common photoproperties emerge despite differences in their atomistic structures. By disassembling hierarchically structured eumelanin nanoparticles, we identify the fundamental spectroscopic units to be π-stacked aggregates consisting of only a few layers. Our model explains how common photoproperties including transient spectral hole burning and excitation-wavelength-dependent emission arise from the ensemble behavior of these units. Our findings underscore the importance of focusing on how properties evolve through different levels of hierarchical assembly and provide a foundation for a unified photophysical framework that spans natural and lab-made carbon-based nanomaterials.","PeriodicalId":10,"journal":{"name":"ACS Central Science","volume":"12 5","pages":"586–598"},"PeriodicalIF":10.4,"publicationDate":"2026-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acscentsci.5c02304","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148010824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pharm to Table Podcast Duo Bridges the Academia–Industry Divide 从制药到餐桌播客二人组弥合了学术界和工业界的鸿沟

IF 10.4 1区化学

ACS Central Science Pub Date : 2026-05-27 Epub Date: 2026-04-24 DOI: 10.1021/acscentsci.6c00691

Mark Peplow,

引用次数: 0

Interfacial Dynamics Accelerate Aging Yet Sustain Toughness in Poly(l-lactide) Block Polymer Plastics 界面动力学加速老化但保持韧性的聚（l-丙交酯）块体聚合物塑料

IF 10.4 1区化学

ACS Central Science Pub Date : 2026-05-27 Epub Date: 2026-05-11 DOI: 10.1021/acscentsci.6c00278

Daniel M. Krajovic, , , Benjamin D. Chayet, , and , Marc A. Hillmyer*,

{"title":"Interfacial Dynamics Accelerate Aging Yet Sustain Toughness in Poly(l-lactide) Block Polymer Plastics","authors":"Daniel M. Krajovic, , , Benjamin D. Chayet, , and , Marc A. Hillmyer*, ","doi":"10.1021/acscentsci.6c00278","DOIUrl":"https://doi.org/10.1021/acscentsci.6c00278","url":null,"abstract":"Poly(lactide) (PLA) homopolymer embrittles under ambient conditions within two days after melt processing through physical aging, which restricts its growth as a sustainable alternative to petroleum-derived, nondegradable plastics. Block polymers containing PLA and immiscible rubbery segments have shown promising mechanical longevity, though only at very high total molar masses. To elucidate the basic architectural and morphological features of such aging-resistant materials, we used a straightforward two-step synthetic route to generate a library of n-arm block polymer plastics (n = 1–4) with poly(γ-methyl-ε-caprolactone) (PγMCL) as the rubbery core and poly(l-lactide) (PLLA) as the outer block, fixing PLLA content at 80 wt %. Triblocks and star-blocks (i.e., n ≥ 2) exhibited high tensile toughness that persisted over long aging times even in samples with poorly entangled PLLA matrices. Crystallinity and architectural purity also promoted mechanical longevity. Calorimetry revealed that the most mechanically long-lived specimens, with MPLLA < 35 kg mol–1, exhibited the fastest physical aging, which we ascribed to a coupling of block dynamics near the segregated PγMCL domain interfaces. Our results broaden the scope of viable block polymer architectures for PLLA mechanical longevity to more synthetically accessible macromolecules that are practically advantageous for scalability and melt processing.","PeriodicalId":10,"journal":{"name":"ACS Central Science","volume":"12 5","pages":"684–694"},"PeriodicalIF":10.4,"publicationDate":"2026-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acscentsci.6c00278","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148010323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Prodrug Strategy to Conditionally Trap Therapeutic Payloads for Improved Tumor Retention 有条件地捕获治疗有效载荷以改善肿瘤保留的药物前策略

IF 10.4 1区化学

ACS Central Science Pub Date : 2026-05-27 Epub Date: 2026-05-13 DOI: 10.1021/acscentsci.6c00185

Deokhee Kang, , , Apurva Pandey, , , Garima Kumar, , , Abijeet Singh Mehta, , , Tyler C. Detomasi, , , Dashiell Anderson, , , Conner Bardine, , , Garrison Asper, , , Junyang Qi, , , Isha Nadig, , , Yifan Cui, , , Fiona M. Quimby, , , Jesse Ling, , , Youngho Seo, , , Bruce E. Cohen, , , Mekhail Anwar, , , Michael J. Evans*, , and , Charles S. Craik*,

{"title":"A Prodrug Strategy to Conditionally Trap Therapeutic Payloads for Improved Tumor Retention","authors":"Deokhee Kang, , , Apurva Pandey, , , Garima Kumar, , , Abijeet Singh Mehta, , , Tyler C. Detomasi, , , Dashiell Anderson, , , Conner Bardine, , , Garrison Asper, , , Junyang Qi, , , Isha Nadig, , , Yifan Cui, , , Fiona M. Quimby, , , Jesse Ling, , , Youngho Seo, , , Bruce E. Cohen, , , Mekhail Anwar, , , Michael J. Evans*, , and , Charles S. Craik*, ","doi":"10.1021/acscentsci.6c00185","DOIUrl":"https://doi.org/10.1021/acscentsci.6c00185","url":null,"abstract":"Altered extracellular proteolysis has been exploited to selectively activate therapeutics in diseases such as cancer; however, once activated, extracellular drugs can diffuse away, limiting efficacy. We address this challenge by coupling proteolytic activation with membrane tethering to retain drugs within diseased tissue. To accomplish this, we developed “restricted interaction peptides” (RIPs), a delivery platform that leverages elevated proteolytic activity to activate membrane-interacting peptides, localizing cargos near the site of proteolysis. We demonstrate that RIPs can deliver diverse therapeutic cargos, including cytotoxins and radioisotopes. As proof of concept, we engineered “FRIP,” a RIP designed for cleavage by fibroblast activation protein (FAP), an endoprotease upregulated in solid tumors and fibrosis. Efficient P4–P4’ substrate sequences were identified and incorporated into FRIPs. Cell-based studies showed that, upon activation, the peptide adhered to membranes rapidly internalized and successfully delivered therapeutic cargos. Consistent with this, FRIPs delivering MMAE inhibited proliferation in an FAP-dependent manner. Imaging studies confirmed tumor targeting with minimal uptake in normal tissues. Finally, FRIPs delivering MMAE or Cu-67 exhibited potent antitumor effects. These findings establish membrane tethering as a strategy to enhance drug retention.","PeriodicalId":10,"journal":{"name":"ACS Central Science","volume":"12 5","pages":"719–730"},"PeriodicalIF":10.4,"publicationDate":"2026-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acscentsci.6c00185","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148010423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of Keystone Macrolide Antibiotics via Selective Oxidation 选择性氧化法开发Keystone大环内酯类抗生素

IF 10.4 1区化学

ACS Central Science Pub Date : 2026-05-27 Epub Date: 2026-05-12 DOI: 10.1021/acscentsci.6c00689

Eléonore Moore, and , Amy E. Fraley,

引用次数: 0

In Situ Kinetics of Solution-Phase Biomolecular Reactions and Interactions through Single-Molecule Displacement Statistics 通过单分子位移统计的溶液相生物分子反应和相互作用的原位动力学

IF 10.4 1区化学

ACS Central Science Pub Date : 2026-05-27 Epub Date: 2026-05-05 DOI: 10.1021/acscentsci.6c00063

Wan Li, and , Ke Xu*,

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引用次数: 0