ACS Central Science最新文献_第9页

Wash-free Imaging in Live Cells. 活细胞免洗成像

IF 12.7 1区化学

ACS Central Science Pub Date : 2025-01-06 eCollection Date: 2025-01-22 DOI: 10.1021/acscentsci.4c02083

Mahdi Hasan, Ashraf Brik

引用次数: 0

Wash-free Imaging in Live Cells

IF 12.7 1区化学

ACS Central Science Pub Date : 2025-01-06 DOI: 10.1021/acscentsci.4c0208310.1021/acscentsci.4c02083

Mahdi Hasan, and , Ashraf Brik*,

引用次数: 0

NSF NeXUS: A New Model for Accessing the Frontiers of Ultrafast Science.

IF 12.7 1区化学

ACS Central Science Pub Date : 2025-01-06 eCollection Date: 2025-01-22 DOI: 10.1021/acscentsci.4c01682

L Robert Baker, Louis F DiMauro, Claudia Turro, Jay A Gupta, Roland K Kawakami, Thomas K Allison, Theodore J Ronningen, Timothy D Scarborough, Vyacheslav Leshchenko, Seth S Shields, John E Beetar

引用次数: 0

NSF NeXUS: A New Model for Accessing the Frontiers of Ultrafast Science

IF 12.7 1区化学

ACS Central Science Pub Date : 2025-01-06 DOI: 10.1021/acscentsci.4c0168210.1021/acscentsci.4c01682

L. Robert Baker*, Louis F. DiMauro, Claudia Turro, Jay A. Gupta, Roland K. Kawakami, Thomas K. Allison, Theodore J. Ronningen, Timothy D. Scarborough, Vyacheslav Leshchenko, Seth S. Shields and John E. Beetar,

引用次数: 0

Identifying Opportunity Targets in Gram-Negative Pathogens for Infectious Disease Mitigation

IF 12.7 1区化学

ACS Central Science Pub Date : 2025-01-03 DOI: 10.1021/acscentsci.4c0143710.1021/acscentsci.4c01437

Isaac A. Paddy, and , Laura M. K. Dassama*,

{"title":"Identifying Opportunity Targets in Gram-Negative Pathogens for Infectious Disease Mitigation","authors":"Isaac A. Paddy,  and , Laura M. K. Dassama*, ","doi":"10.1021/acscentsci.4c0143710.1021/acscentsci.4c01437","DOIUrl":"https://doi.org/10.1021/acscentsci.4c01437https://doi.org/10.1021/acscentsci.4c01437","url":null,"abstract":"Antimicrobial drug resistance (AMR) is a pressing global human health challenge. Humans face one of their grandest challenges as climate change expands the habitat of vectors that bear human pathogens, incidences of nosocomial infections rise, and new antibiotics discovery lags. AMR is a multifaceted problem that requires a multidisciplinary and an “all-hands-on-deck” approach. As chemical microbiologists, we are well positioned to understand the complexities of AMR while seeing opportunities for tackling the challenge. In this Outlook, we focus on vulnerabilities of human pathogens and posit that they represent “opportunity targets” for which few modulatory ligands exist. We center our attention on proteins in Gram-negative organisms, which are recalcitrant to many antibiotics because of their external membrane barrier. Our hope is to highlight such targets and explore their potential as “druggable” proteins for infectious disease mitigation. We posit that success in this endeavor will introduce new classes of antibiotics that might alleviate some of the current pressing AMR concerns.Antibiotic resistance is rapidly increasing while discovery of new drugs lags. Uncovering of new druggable targets could increase the number of antibiotics and temporarily abate the AMR crisis.","PeriodicalId":10,"journal":{"name":"ACS Central Science","volume":"11 1","pages":"25–35 25–35"},"PeriodicalIF":12.7,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acscentsci.4c01437","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143090607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identifying Opportunity Targets in Gram-Negative Pathogens for Infectious Disease Mitigation. 识别革兰氏阴性病原体中的机会目标，缓解传染病。

IF 12.7 1区化学

ACS Central Science Pub Date : 2025-01-03 eCollection Date: 2025-01-22 DOI: 10.1021/acscentsci.4c01437

Isaac A Paddy, Laura M K Dassama

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引用次数: 0

Enhancing the Optically Detected Magnetic Resonance Signal of Organic Molecular Qubits.

IF 12.7 1区化学

ACS Central Science Pub Date : 2025-01-03 eCollection Date: 2025-01-22 DOI: 10.1021/acscentsci.4c01632

Yong Rui Poh, Joel Yuen-Zhou

{"title":"Enhancing the Optically Detected Magnetic Resonance Signal of Organic Molecular Qubits.","authors":"Yong Rui Poh, Joel Yuen-Zhou","doi":"10.1021/acscentsci.4c01632","DOIUrl":"10.1021/acscentsci.4c01632","url":null,"abstract":"In quantum information science and sensing, electron spins are often purified into a specific polarization through an optical-spin interface, a process known as optically detected magnetic resonance (ODMR). Diamond-NV centers and transition metals are both excellent platforms for these so-called color centers, while metal-free molecular analogues are also gaining popularity for their extended polarization lifetimes, milder environmental impacts, and reduced costs. In our earlier attempt at designing such organic high-spin π-diradicals, we proposed to spin-polarize by shelving triplet M S = ±1 populations as singlets. This was recently verified by experiments albeit with low ODMR contrasts of <1% at temperatures above 5 K. In this work, we propose to improve the ODMR signal by moving singlet populations back into the triplet M S = 0 sublevel, designing a true carbon-based molecular analogue to the NV center. Our proposal is based upon transition-orbital and group-theoretical analyses of beyond-nearest-neighbor spin-orbit couplings, which are further confirmed by ab initio calculations of a realistic trityl-based radical dimer. Microkinetic analyses point toward high ODMR contrasts of around 30% under experimentally feasible conditions, a stark improvement from previous works. Finally, in our quest toward ground-state optically addressable molecular spin qubits, we exemplify how our symmetry-based design avoids Zeeman-induced singlet-triplet mixings, setting the scene for realizing electron spin qubit gates.","PeriodicalId":10,"journal":{"name":"ACS Central Science","volume":"11 1","pages":"116-126"},"PeriodicalIF":12.7,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11758272/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143044843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tackling Waste Polystyrene with Sunlight

IF 12.7 1区化学

ACS Central Science Pub Date : 2025-01-02 DOI: 10.1021/acscentsci.4c0218710.1021/acscentsci.4c02187

Hyun Suk Wang, and , Athina Anastasaki*,

引用次数: 0

Enhancing the Optically Detected Magnetic Resonance Signal of Organic Molecular Qubits

IF 12.7 1区化学

ACS Central Science Pub Date : 2025-01-02 DOI: 10.1021/acscentsci.4c0163210.1021/acscentsci.4c01632

Yong Rui Poh*, and , Joel Yuen-Zhou*,

{"title":"Enhancing the Optically Detected Magnetic Resonance Signal of Organic Molecular Qubits","authors":"Yong Rui Poh*,  and , Joel Yuen-Zhou*, ","doi":"10.1021/acscentsci.4c0163210.1021/acscentsci.4c01632","DOIUrl":"https://doi.org/10.1021/acscentsci.4c01632https://doi.org/10.1021/acscentsci.4c01632","url":null,"abstract":"In quantum information science and sensing, electron spins are often purified into a specific polarization through an optical-spin interface, a process known as optically detected magnetic resonance (ODMR). Diamond-NV centers and transition metals are both excellent platforms for these so-called color centers, while metal-free molecular analogues are also gaining popularity for their extended polarization lifetimes, milder environmental impacts, and reduced costs. In our earlier attempt at designing such organic high-spin π-diradicals, we proposed to spin-polarize by shelving triplet MS = ±1 populations as singlets. This was recently verified by experiments albeit with low ODMR contrasts of <1% at temperatures above 5 K. In this work, we propose to improve the ODMR signal by moving singlet populations back into the triplet MS = 0 sublevel, designing a true carbon-based molecular analogue to the NV center. Our proposal is based upon transition-orbital and group-theoretical analyses of beyond-nearest-neighbor spin–orbit couplings, which are further confirmed by ab initio calculations of a realistic trityl-based radical dimer. Microkinetic analyses point toward high ODMR contrasts of around 30% under experimentally feasible conditions, a stark improvement from previous works. Finally, in our quest toward ground-state optically addressable molecular spin qubits, we exemplify how our symmetry-based design avoids Zeeman-induced singlet–triplet mixings, setting the scene for realizing electron spin qubit gates.We propose organic π-diradicals that, upon photoexcitation, will relax through two consecutive spin-changing steps. This aligns the radical spins, observed as a change in the emission signal.","PeriodicalId":10,"journal":{"name":"ACS Central Science","volume":"11 1","pages":"116–126 116–126"},"PeriodicalIF":12.7,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acscentsci.4c01632","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143089417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nickel(II)/Salox-Catalyzed Enantioselective C-H Functionalization. 镍（II）/萨洛催化的对映体选择性 C-H 功能化。

IF 12.7 1区化学

ACS Central Science Pub Date : 2025-01-02 eCollection Date: 2025-01-22 DOI: 10.1021/acscentsci.4c02049

Jia-Hao Chen, Qi-Jun Yao, Ming-Yu Zhong, Tian-Yu Jiang, Fan-Rui Huang, Xiang Li, Bing-Feng Shi

{"title":"Nickel(II)/Salox-Catalyzed Enantioselective C-H Functionalization.","authors":"Jia-Hao Chen, Qi-Jun Yao, Ming-Yu Zhong, Tian-Yu Jiang, Fan-Rui Huang, Xiang Li, Bing-Feng Shi","doi":"10.1021/acscentsci.4c02049","DOIUrl":"10.1021/acscentsci.4c02049","url":null,"abstract":"Recently, nickel catalysts have garnered considerable attention for their efficacy and versatility in asymmetric catalysis, attributed to their distinctive properties. However, the use of cost-effective and sustainable divalent nickel catalysts in C-H activation/asymmetric alkene insertion poses significant challenges due to the intricate control of stereochemistry in the transformation of the tetracoordinate C-Ni(II) intermediate. Herein, we report a Ni(II)-catalyzed enantioselective C-H/N-H annulation with oxabicyclic alkenes. This protocol offers straightforward access to chiral [2,2,1]-bridged bicyclic compounds bearing four consecutive stereocenters with high enantioselectivity (up to 96% ee). The development of a sterically hindered chiral salicyloxazoline (Salox) ligand, TMS-Salox, is key to the success of this protocol. Mechanistic investigations unveiled that a chiral Ni(III)-metalacyclic intermediate was formed through the in situ oxidation of achiral organometallic Ni(II) species and coordination of the Salox ligand. This process led to the creation of a tailored chiral pocket that guides the approach of alkenes, thereby influencing and determining the stereochemistry.","PeriodicalId":10,"journal":{"name":"ACS Central Science","volume":"11 1","pages":"127-135"},"PeriodicalIF":12.7,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11758223/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143044851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0