Stephanie C. Hammel*, Helle Vibeke Andersen, Lisbeth E. Knudsen and Marie Frederiksen,
{"title":"Translating Silicone Wristbands to a Personal Exposure Estimate for Dermal Absorption: A Case Study with PCBs","authors":"Stephanie C. Hammel*, Helle Vibeke Andersen, Lisbeth E. Knudsen and Marie Frederiksen, ","doi":"10.1021/acs.estlett.5c0034610.1021/acs.estlett.5c00346","DOIUrl":"https://doi.org/10.1021/acs.estlett.5c00346https://doi.org/10.1021/acs.estlett.5c00346","url":null,"abstract":"<p >Dermal absorption is an exposure pathway frequently underestimated due to challenges in quantifying how exogenous chemicals pass through skin. Silicone wristbands have been used as effective personal passive sampling tools for semivolatile organic compounds (SVOCs) and serve as integrated measures of inhalation and dermal exposures. However, to-date, translating SVOC concentrations in wristbands to estimated doses has been a gap for their application in exposure assessment. Here, we utilized wristbands as proxy measures for skin-surface lipids to calculate estimated daily intakes (EDIs) from the dermal absorption pathway. EDIs were compared to dermal uptake estimates previously calculated from indoor air measurements and hand wipes, which were collected from residents of both polychlorinated biphenyl (PCB)-contaminated and noncontaminated buildings. Wristband-based estimates showed strong agreement with those from air and hand wipes (r<sub>s</sub> > 0.8, <i>p</i> < 0.0001), particularly for lower chlorinated PCBs, with dermal uptake accounting for a third of exposed residents’ PCB exposure (∑<sub>7</sub>PCB = 29.2 ng/kg bodyweight/day). All three dermal estimates were significantly associated with serum measurements among the lower chlorinated congeners. Our results demonstrate wristbands’ potential for quantifying personal external exposure, building on their utility for ranking internal dose. This study further presents a method for using wristbands to calculate dermal absorption for personalized exposure assessment.</p>","PeriodicalId":37,"journal":{"name":"Environmental Science & Technology Letters Environ.","volume":"12 5","pages":"524–529 524–529"},"PeriodicalIF":8.9,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acs.estlett.5c00346","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143934317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pierre Liboureau*, Philip Tanabe, Enrico Riccardi, Daniel Schlenk, Kristy Forsgren and Daniela M. Pampanin*,
{"title":"Automated Identification of Histological Lesions in Nonmodel Organisms: Reinvigorating Environmental Science","authors":"Pierre Liboureau*, Philip Tanabe, Enrico Riccardi, Daniel Schlenk, Kristy Forsgren and Daniela M. Pampanin*, ","doi":"10.1021/acs.estlett.5c0029510.1021/acs.estlett.5c00295","DOIUrl":"https://doi.org/10.1021/acs.estlett.5c00295https://doi.org/10.1021/acs.estlett.5c00295","url":null,"abstract":"<p >In response to contaminants, alterations of tissue morphology and function can reflect ecosystem health and be irreversible. Traditional assessments require highly trained personnel, are cost- and time-ineffective and produce subjective, qualitative results susceptible to bias. Automated digital histology aims to address these challenges while relieving the burden on pathologists and increasing the meaningfulness and reproducibility of findings. Over the past few years, technological advances in image recognition facilitated the analysis of content-dense histological images for human health. Herein, we applied such advancements to environmental science, and automated digital histology was tested for the identification of lesions (steatosis, melano-macrophage aggregates, leucocyte infiltration, and granuloma) in livers from two fish species (<i>Gadus morhua</i> and <i>Limanda limanda</i>) sampled near oil and gas platforms. Images scored by professional histopathologists were used to train a machine learning model on hematoxylin and eosin-stained whole slide images. The automated digital detections corresponded well with traditional assessments (between 85% and 95%) but required less expertise and were faster. Our results demonstrate a viable path toward a complete, automated workflow for fast, cost-effective and accurate digital histology analysis of environmental and ecotoxicology samples. Efficient, accessible digital histology models will advance understanding of ongoing environmental changes and enhance future preparedness.</p>","PeriodicalId":37,"journal":{"name":"Environmental Science & Technology Letters Environ.","volume":"12 5","pages":"518–523 518–523"},"PeriodicalIF":8.9,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acs.estlett.5c00295","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143933631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mindong Ma, Ying Yang, Ziye Zhang, Daoyuan Yang, Song Cui, Haixia Sui* and Lihui An*,
{"title":"Increased Microplastic Intake from Fry-Cooked Fish Muscle Tissue","authors":"Mindong Ma, Ying Yang, Ziye Zhang, Daoyuan Yang, Song Cui, Haixia Sui* and Lihui An*, ","doi":"10.1021/acs.estlett.5c0034910.1021/acs.estlett.5c00349","DOIUrl":"https://doi.org/10.1021/acs.estlett.5c00349https://doi.org/10.1021/acs.estlett.5c00349","url":null,"abstract":"<p >The health risks of microplastic exposure have raised global concerns due to their ubiquitous presence. While current studies emphasize microplastic detection in seafood, the influence of cooking methods remains understudied, potentially biasing risk assessments. This study employed both laser direct infrared spectroscopy to detect microplastics larger than 20 μm and pyrolysis thermal desorption–gas chromatography–mass spectrometry to quantify microplastics exceeding 0.22 μm, aiming to comprehensively evaluate microplastic variations in fish muscle tissue after boiling, steaming, and frying. Frying significantly elevated microplastic abundance in fish muscle (<i>p</i> < 0.05), from 4.00 ± 3.01 to 36.43 ± 14.39 items/g (corresponding to 32.30 ± 11.20 and 58.09 ± 24.94 μg/g), whereas steaming and boiling showed no significant changes (<i>p</i> > 0.05). Notably, sub-20 μm microplastics were identified in fish muscle, with polyvinyl chloride fragmentation during frying as a primary contributor. These findings provide novel insights into cooking-induced microplastic dynamics in seafood, advancing risk assessments for dietary microplastic exposure.</p>","PeriodicalId":37,"journal":{"name":"Environmental Science & Technology Letters Environ.","volume":"12 5","pages":"530–534 530–534"},"PeriodicalIF":8.9,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143933796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Veronica van der Schyff*, Marek Stiborek, Zdeněk Šimek, Branislav Vrana, Verena Meraldi, Andrew Luke King and Lisa Melymuk,
{"title":"Occurrence of Pharmaceuticals and Other Anthropogenic Compounds in the Wastewater Effluent of Arctic Expedition Cruise Ships","authors":"Veronica van der Schyff*, Marek Stiborek, Zdeněk Šimek, Branislav Vrana, Verena Meraldi, Andrew Luke King and Lisa Melymuk, ","doi":"10.1021/acs.estlett.5c0020910.1021/acs.estlett.5c00209","DOIUrl":"https://doi.org/10.1021/acs.estlett.5c00209https://doi.org/10.1021/acs.estlett.5c00209","url":null,"abstract":"<p >Cruise ship traffic in polar regions is increasing, but we lack a good understanding of the emissions from these ships to sensitive marine environments. Wastewater discharges may result in the release of contaminants of emerging concern into such environments. Treated wastewater from three expedition cruise ships was collected and analyzed with a focus on pharmaceuticals, personal care products, and industrial chemicals. Samples were screened using data-dependent acquisition using liquid chromatography-high-resolution mass spectrometry (LC-HRMS). More than 160 compounds were identified at Schymanski level 1 or 2 (SL1 or SL2, respectively) in treated wastewater across all three ships. Twenty-seven compounds were identified in wastewater from all three ships, suggesting their potential wider presence in ship wastewater and warranting further investigation. For all ships, pharmaceuticals dominated in terms of the number of compounds identified at SL1 or SL2 (43–59%), primarily cardiovascular medications, followed by industrial chemicals (21–31%) and natural compounds (12–17%). Multiple antibiotics were identified at SL1, raising concerns that ship wastewater effluent could contribute to the undesired spread of antibiotic-resistance genes. With the ongoing growth of the cruise industry and uncertainties related to impacts on sensitive marine environments, further investigation of ship wastewater emissions is recommended.</p>","PeriodicalId":37,"journal":{"name":"Environmental Science & Technology Letters Environ.","volume":"12 5","pages":"648–654 648–654"},"PeriodicalIF":8.9,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acs.estlett.5c00209","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143933895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yutong Wang, Diwen Yang, William D. Fahy, Laura-Helena Rivellini, Alex K.Y. Lee, Hui Peng and Jonathan P.D. Abbatt*,
{"title":"Increased UV–Visible Particle Absorption via Evaporation and Drying of Aqueous Droplets Containing Catechol/HONO Solutions","authors":"Yutong Wang, Diwen Yang, William D. Fahy, Laura-Helena Rivellini, Alex K.Y. Lee, Hui Peng and Jonathan P.D. Abbatt*, ","doi":"10.1021/acs.estlett.5c0036410.1021/acs.estlett.5c00364","DOIUrl":"https://doi.org/10.1021/acs.estlett.5c00364https://doi.org/10.1021/acs.estlett.5c00364","url":null,"abstract":"<p >The role of cloud droplet evaporation in brown carbon (BrC) formation is poorly established with previous studies focusing on carbonyl/(NH<sub>4</sub>)<sub>2</sub>SO<sub>4</sub> solutions and secondary organic aerosols (SOA). Here, by mixing dry air into an aerosol flow reactor, we examine whether droplet evaporation may affect wildfire BrC by studying the aqueous nitration of catechol by HONO and darkening of the soluble component of wood smoke. Using online aethalometry and offline UV–vis analysis of particle filter extracts, we observe for the catechol/HONO system that droplet evaporation leads to significantly increased mass absorption coefficients and enhanced ratios of visible to UV absorption compared to bulk solutions, consistent with offline mass spectrometric analysis of dried particles that indicates aromatic nitration and oligomer formation. Differences between the aethalometer and UV–vis filter measurements are attributed to reactions on the dry filter that enhance BrC formation. Evaporation of wood smoke extract droplets also leads to darkening reactions but much less significantly than with catechol/HONO, as expected if only a select fraction of the wood smoke molecules react via concentration enhancement. These findings underscore droplet evaporation/drying as important to BrC atmospheric evolution and suggest that dryer usage may affect particle composition in field measurements.</p>","PeriodicalId":37,"journal":{"name":"Environmental Science & Technology Letters Environ.","volume":"12 5","pages":"619–625 619–625"},"PeriodicalIF":8.9,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143934505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Molly T. Radosevich, Sarah Dobson, Amanda K. Weaver, Phinehas Lampman, Daniel Kollath, Lisa Couper, Grace Campbell, John W. Taylor, Justin V. Remais, Leda Kobziar, James Markwiese and Jennifer R. Head*,
{"title":"Detection of Airborne Coccidioides Spores Using Lightweight Portable Air Samplers Affixed to Uncrewed Aircraft Systems in California’s Central Valley","authors":"Molly T. Radosevich, Sarah Dobson, Amanda K. Weaver, Phinehas Lampman, Daniel Kollath, Lisa Couper, Grace Campbell, John W. Taylor, Justin V. Remais, Leda Kobziar, James Markwiese and Jennifer R. Head*, ","doi":"10.1021/acs.estlett.4c0108910.1021/acs.estlett.4c01089","DOIUrl":"https://doi.org/10.1021/acs.estlett.4c01089https://doi.org/10.1021/acs.estlett.4c01089","url":null,"abstract":"<p >Coccidioidomycosis is an emerging fungal infection caused by inhalation of <i>Coccidioides</i> spp. spores. While airborne dispersal is critical to <i>Coccidioides</i> transmission, limited recovery of the pathogen from air has hindered understanding of the aerosolization and transport of spores. Here, we examine uncrewed aircraft systems (UAS) with portable, active air samplers as a novel means of capturing aerosolized <i>Coccidioides</i> and characterizing emissions and exposure risk. We sampled in September 2023 in eastern San Luis Obispo County, California, in an area with confirmed <i>Coccidioides immitis</i> in soils. We completed 41 20 min flights across 14 sites using UAS equipped with an 8 L/min bioaerosol sampler and a low-cost particulate matter sensor. We sampled source soils and air under ambient conditions using one UAS at 1–10 m above ground level, and under a simulated high-dust event using two UAS, one at <2 m height and one at 5–12 m. We detected <i>Coccidioides</i> DNA in 2 of 41 air samples (4.9%), both under ambient conditions at 8 m above ground level, representing the highest known height of airborne <i>Coccidioides</i> detection. Spatially explicit UAS-based sampling could enhance understanding of <i>Coccidioides</i> aerobiology and enable detection in hard-to-reach or hazardous air masses, including dust storms and wildfire smoke.</p>","PeriodicalId":37,"journal":{"name":"Environmental Science & Technology Letters Environ.","volume":"12 5","pages":"580–586 580–586"},"PeriodicalIF":8.9,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acs.estlett.4c01089","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143934102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zezhen Cheng, Swarup China, Weinan Leng, Aaron J. Prussin II and Linsey C. Marr*,
{"title":"Second Correction to “Size-Resolved Elemental Composition of Respiratory Particles in Three Healthy Subjects”","authors":"Zezhen Cheng, Swarup China, Weinan Leng, Aaron J. Prussin II and Linsey C. Marr*, ","doi":"10.1021/acs.estlett.5c0035010.1021/acs.estlett.5c00350","DOIUrl":"https://doi.org/10.1021/acs.estlett.5c00350https://doi.org/10.1021/acs.estlett.5c00350","url":null,"abstract":"","PeriodicalId":37,"journal":{"name":"Environmental Science & Technology Letters Environ.","volume":"12 5","pages":"684–686 684–686"},"PeriodicalIF":8.9,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143934176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Critical Comparative Study of Boron Removal from Synthetic Single-Stage Seawater Reverse Osmosis Permeate by BPM- and AEM-Assisted Electrosorption","authors":"Jingyi Sun, Shikha Garg and T. David Waite*, ","doi":"10.1021/acs.estlett.5c0024910.1021/acs.estlett.5c00249","DOIUrl":"https://doi.org/10.1021/acs.estlett.5c00249https://doi.org/10.1021/acs.estlett.5c00249","url":null,"abstract":"<p >Membrane-assisted electrosorption, particularly the utilization of anion exchange membrane (AEM)- and bipolar membrane (BPM)-assisted systems, has garnered increasing interest as an effective technology for boron removal from a single-stage reverse osmosis (RO) permeate. In this study, we systematically examine the key factors─supporting electrolyte composition, charging voltage, and discharging voltage─that impact boron removal performance in both setups, with the insights provided aiding both process optimization and full-scale application. Our results indicate that, while the BPM-assisted system operates at a relatively lower cell voltage and consumes approximately 67% the amount of the energy used by the AEM-assisted system, the requirement for additional salt for sufficient conductivity and water dissociation is impractical for removal of boron from the RO permeate. Furthermore, due to the high cost of BPMs, the overall operational cost of the BPM-assisted system is ∼5-fold higher than that of the AEM-assisted system. Our results further show that applying a reverse potential (−1 V) during discharge desorbs only ∼60–65% of the boron, suggesting that electrode/membrane replacement is needed to maintain activity. Overall, while membrane-assisted electrosorption shows promise for boron removal from RO permeate, significant advancements are needed for both configurations to improve boron removal rates, reduce electrode and membrane costs, and decrease energy demands.</p>","PeriodicalId":37,"journal":{"name":"Environmental Science & Technology Letters Environ.","volume":"12 5","pages":"677–683 677–683"},"PeriodicalIF":8.9,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143933716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bei Yan*, Riccardo Alessandri, Siewert J. Marrink, Linda S. Lee and Jinxia Liu*,
{"title":"Insight into the Self-Assembly Behaviors of Per- and Polyfluoroalkyl Substances Using a “Computational Microscope”","authors":"Bei Yan*, Riccardo Alessandri, Siewert J. Marrink, Linda S. Lee and Jinxia Liu*, ","doi":"10.1021/acs.estlett.4c0108110.1021/acs.estlett.4c01081","DOIUrl":"https://doi.org/10.1021/acs.estlett.4c01081https://doi.org/10.1021/acs.estlett.4c01081","url":null,"abstract":"<p >Aqueous film-forming foams (AFFFs) have been extensively used for firefighting, contributing to environmental contamination with per- and polyfluoroalkyl substances (PFAS). Most PFAS in AFFFs are fluorosurfactants, known to self-assemble into large supramolecular assemblies in the field of physical chemistry; however, the application of this phenomenon to understanding environmental fate has not been studied. We hypothesize that self-assembled PFAS likely enhance the long-term retention of PFAS in subsurface environments, acting as a continuous source of dissolved PFAS. Thus, characterizing these self-assemblies and understanding their aggregation dynamics are crucial for assessing the fate and transport of PFAS. Despite the utility of molecular dynamics (MD) simulation in studying surfactant behaviors, fluorosurfactants have been underexplored due to the lack of force field parameters. In this study, we developed coarse-grained (CG) force field parameters for fluorosurfactants based on the Martini 3 model and performed CG-MD simulations. These “computational microscope” simulations reveal the self-assembly behavior of selected PFAS, aligning with experimental cryo-transmission electron microscopy observations and providing mechanistic insights. Our work sheds light on the evolution of solvated PFAS self-assemblies over time and space. The CG-MD simulation can particularly address the knowledge gaps for new PFAS that are difficult to explore experimentally due to the lack of chemical standards.</p>","PeriodicalId":37,"journal":{"name":"Environmental Science & Technology Letters Environ.","volume":"12 5","pages":"626–631 626–631"},"PeriodicalIF":8.9,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143933735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"PM2.5 Components and Fetal Chromosomal Abnormalities: Identifying Critical Exposure Windows","authors":"Xiaozhou Li, Yuqi Guo, Deyan Wu, Jia Xu, Bin Han, Xueli Yang, Duan Ju, Ying Zhang, Zhipeng Bai, Chen Li* and Liwen Zhang*, ","doi":"10.1021/acs.estlett.5c0020610.1021/acs.estlett.5c00206","DOIUrl":"https://doi.org/10.1021/acs.estlett.5c00206https://doi.org/10.1021/acs.estlett.5c00206","url":null,"abstract":"<p >PM<sub>2.5</sub> is genotoxic and linked to fetal chromosomal abnormalities. This study aims to explore the association between PM<sub>2.5</sub> components (SO<sub>4</sub><sup>2–</sup>, NO<sub>3</sub><sup>–</sup>, NH<sub>4</sub><sup>+</sup>, OM, BC) and fetal chromosomal abnormalities. We conducted a cross-sectional study spanning four consecutive years (2019–2022), using samples collected from General Hospital of Tianjin Medical University. A total of 901 samples were analyzed, including 95 cases. Logistic regression and stratified analyses were employed to examine the associations between specific PM<sub>2.5</sub> components and fetal chromosomal abnormalities across 14 distinct exposure windows. The goal was to identify the critical periods of exposure that may contribute to fetal chromosomal abnormalities and to screen vulnerable subgroups. Our findings revealed significant associations between PM<sub>2.5</sub> components (NO<sub>3</sub><sup>–</sup>, NH<sub>4</sub><sup>+</sup>, OM) and fetal chromosomal abnormalities during four key exposure windows: 8, 12, and 16 weeks prior to the last menstrual period, as well as during spermatogenesis. Younger pregnant women (<35 years) and those with higher or lower BMI were found to be more susceptible to PM<sub>2.5</sub> components, increasing the risk to their fetus. These findings suggest that minimizing maternal exposure to PM<sub>2.5</sub> during these critical time windows and maintaining a normal BMI may effectively reduce the incidence of fetal chromosomal abnormalities.</p>","PeriodicalId":37,"journal":{"name":"Environmental Science & Technology Letters Environ.","volume":"12 5","pages":"482–489 482–489"},"PeriodicalIF":8.9,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143933894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}