{"title":"EXPECTATION-MAXIMIZATION FOR STRUCTURE DETERMINATION DIRECTLY FROM CRYO-EM MICROGRAPHS.","authors":"Shay Kreymer, Amit Singer, Tamir Bendory","doi":"10.3934/ipi.2026033","DOIUrl":"10.3934/ipi.2026033","url":null,"abstract":"<p><p>A single-particle cryo-electron microscopy (cryo-EM) measurement, called a micrograph, consists of multiple two-dimensional tomographic projections of a three-dimensional (3-D) molecular structure at unknown locations, taken under unknown viewing directions. All existing cryo-EM algorithmic pipelines first locate and extract the projection images, and then reconstruct the structure from the extracted images. However, if the molecular structure is small, the signal-to-noise ratio (SNR) of the data is very low, making it challenging to accurately detect projection images within the micrograph. Consequently, all standard techniques fail in low-SNR regimes. To recover molecular structures from measurements of low SNR, and in particular small molecular structures, we devise an approximate expectation-maximization algorithm to estimate the 3-D structure directly from the micrograph, bypassing the need to locate the projection images. We corroborate our computational scheme with numerical experiments and present successful structure recoveries from simulated noisy measurements.</p>","PeriodicalId":50274,"journal":{"name":"Inverse Problems and Imaging","volume":"27 ","pages":"110-133"},"PeriodicalIF":1.6,"publicationDate":"2027-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13384443/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148609636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Threshold dynamics of a reaction-diffusion-advection schistosomiasis model with seasonality","authors":"Yijie Zha , Xun Cao","doi":"10.1016/j.nonrwa.2026.104617","DOIUrl":"10.1016/j.nonrwa.2026.104617","url":null,"abstract":"<div><div>This paper proposes a reaction-diffusion-advection schistosomiasis model with seasonality based on the life cycle of schistosomiasis (humans, eggs, snails, and cercariae). Using the next generation operator theory, we define the basic reproduction number <span><math><msub><mi>R</mi><mn>0</mn></msub></math></span> that characterizes the transmission potential of schistosomiasis, and further reveal the threshold dynamics of the system through the monotone dynamical system theory. Specifically, if <span><math><mrow><msub><mi>R</mi><mn>0</mn></msub><mo>≤</mo><mn>1</mn></mrow></math></span>, the disease-free periodic solution is globally asymptotically stable, meaning that schistosomiasis will die out; if <span><math><mrow><msub><mi>R</mi><mn>0</mn></msub><mo>></mo><mn>1</mn></mrow></math></span>, the system admits a unique positive periodic solution that is globally asymptotically stable, indicating that the disease will break out. Numerically, we use data from Ourinhos, Brazil, to analyze the impact of diffusion rates, spatial heterogeneity, advection rates, and seasonality on the transmission of schistosomiasis.</div></div>","PeriodicalId":49745,"journal":{"name":"Nonlinear Analysis-Real World Applications","volume":"92 ","pages":"Article 104617"},"PeriodicalIF":1.8,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146116723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Well-posedness results and global attractors for a generalized coupled dynamical system","authors":"Xiuwen Li , Zhenhai Liu , Jing Zhao","doi":"10.1016/j.nonrwa.2026.104615","DOIUrl":"10.1016/j.nonrwa.2026.104615","url":null,"abstract":"<div><div>Our present paper investigates theoretical results concerning the well-posedness and global attractor of a novel class of generalized coupling dynamical systems (GCDSs). The system comprises an abstract nonlinear differential inclusion with a history-dependent (h.d.) operator and a generalized variational-hemivariational inequality (GVHVI) with two h.d. operators, formulated within Banach spaces. Our study unfolds in four key aspects. First, we introduce and establish the well-posedness results of the GVHVI by employing the surjectivity theorem for multivalued mappings and techniques from nonlinear functional analysis. Second, we consider and discuss the existence of solutions to the GCDSs by using fixed-point theory under some suitable assumptions. Third, we explore and derive the existence of global attractors for the multivalued semiflow (<em>m</em>-semiflow) described by the GCDSs under some sufficient conditions. Finally, we present an application to a coupled problem, demonstrating the applicability of our theoretical findings.</div></div>","PeriodicalId":49745,"journal":{"name":"Nonlinear Analysis-Real World Applications","volume":"92 ","pages":"Article 104615"},"PeriodicalIF":1.8,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146116724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Sectional Kolmogorov N-widths for parameter-dependent function spaces: a general framework with application to parametrized Friedrichs’ systems","authors":"Christian Engwer, Mario Ohlberger, Lukas Renelt","doi":"10.1007/s10444-026-10375-8","DOIUrl":"10.1007/s10444-026-10375-8","url":null,"abstract":"<div><p>We investigate parametrized variational problems where for each parameter the solution may originate from a different parameter-dependent function space. Our main motivation is the theory of Friedrichs’ systems, a large abstract class of linear PDE problems whose solutions are sought in operator- (and thus parameter-)dependent graph spaces. Other applications include function spaces on parametrized domains or discretizations involving data-dependent stabilizers. Concerning the set of all parameter-dependent solutions, we argue that in these cases, the interpretation as a “solution manifold” widely adopted in the model order reduction community is no longer applicable. Instead, we propose a novel framework based on the theory of fiber bundles and explain how established concepts such as approximability generalize by introducing a sectional Kolmogorov <i>N</i>-width. Further, we prove exponential approximation rates of this <i>N</i>-width if a norm equivalence criterion is fulfilled. Applying this result to problems with Friedrichs’ structure then gives a sufficient criterion that can be easily verified.</p></div>","PeriodicalId":50869,"journal":{"name":"Advances in Computational Mathematics","volume":"52 6","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149214567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Planar Coulomb Gas on a Jordan Arc at Any Temperature","authors":"K. Courteaut, K. Johansson, F. Viklund","doi":"10.1002/cpa.70065","DOIUrl":"https://doi.org/10.1002/cpa.70065","url":null,"abstract":"We study a planar Coulomb gas confined to a sufficiently smooth Jordan arc in the complex plane, at inverse temperature . Let <jats:disp-formula/> be the normalized partition function, where is the capacity of , the entropy of the logarithmic equilibrium measure on , and . We compute the free energy as the number of particles tends to infinity, including the constant term: <jats:disp-formula/> Here is an explicit Selberg integral, is half the Loewner energy of a certain Jordan curve associated to plus a term corresponding to the endpoints of the arc, and is the Fekete energy, related to the zero temperature limit of the model. We also prove an asymptotic formula for the Laplace transform of linear statistics for sufficiently regular test functions. As a consequence, the centered empirical measure converges to a Gaussian field with explicit asymptotic mean, and asymptotic variance given by the Dirichlet energy of the bounded harmonic extension of the test function outside of the arc. A key tool in our analysis is the arc‐Grunsky operator associated to , reminiscent of but different from the classical Grunsky operator. We derive several basic properties of the arc‐Grunsky operator, including an estimate analogous to the strengthened Grunsky inequality and the relation to the Dirichlet integral. In our proofs arises from the Fredholm determinant and a substantial part of the paper is devoted to relating this to the Loewner energy.","PeriodicalId":10601,"journal":{"name":"Communications on Pure and Applied Mathematics","volume":"234 1","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149218629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Maps preserving the maximal numerical range of generalized products of operators","authors":"Nan Wang,Guoxing Ji","doi":"10.1080/03081087.2026.2747248","DOIUrl":"https://doi.org/10.1080/03081087.2026.2747248","url":null,"abstract":"","PeriodicalId":49905,"journal":{"name":"Linear & Multilinear Algebra","volume":"51 1","pages":"1-19"},"PeriodicalIF":1.1,"publicationDate":"2026-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149208910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Improved approximation algorithm for min-max correlation clustering problem with penalties","authors":"Yuebo Huang,Sai Ji,Xiaoyun Tian,Kun Zhou","doi":"10.1007/s10878-026-01496-3","DOIUrl":"https://doi.org/10.1007/s10878-026-01496-3","url":null,"abstract":"","PeriodicalId":50231,"journal":{"name":"Journal of Combinatorial Optimization","volume":"78 1","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149208868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Publisher Correction: Investigation of a Two-Patch Within-Host Model of Hepatitis B Viral Infection.","authors":"Keoni Castellano, Omar Saucedo, Stanca M Ciupe","doi":"10.1007/s11538-026-01780-7","DOIUrl":"https://doi.org/10.1007/s11538-026-01780-7","url":null,"abstract":"","PeriodicalId":9372,"journal":{"name":"Bulletin of Mathematical Biology","volume":"88 11","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149214985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Transcritical Bifurcation at Infinity Governs Plaque Stability in a Lipid-Structured Macrophage Model of Atherosclerosis.","authors":"Emine Atıcı Endes, Neslihan Nesliye Pelen","doi":"10.1007/s11538-026-01751-y","DOIUrl":"https://doi.org/10.1007/s11538-026-01751-y","url":null,"abstract":"<p><p>Atherosclerotic plaques are fatty deposits in arterial walls and a major cause of heart attacks and strokes. Macrophage proliferation triggers plaque growth and instability, but the specific conditions that convert stable plaques into unstable ones remain unclear. To provide insight into the conditions for this transition, we apply bifurcation analysis to the lipid-structured atherosclerosis model proposed by Chambers et al. (Bull Math Biol 86(8):104, 2024). We demonstrate that, in the asymptotic regime where macrophage levels become large ( <math><mrow><mi>M</mi> <mo>→</mo> <mi>∞</mi></mrow> </math> ), the model exhibits an asymptotic fast-slow structure that does not hold outside this limit. Within this asymptotic regime, we reduce the full system onto a slow invariant manifold, providing a simplified yet accurate description of the dynamics near the critical proliferation-emigration threshold. We prove, via centre manifold theory, that the positive steady state loses stability through a transcritical bifurcation at infinity at the critical proliferation-emigration threshold <math> <mrow><msub><mi>ρ</mi> <mi>c</mi></msub> <mo>=</mo> <mn>1</mn> <mo>+</mo> <mi>γ</mi></mrow> </math> . The analysis reveals that the positive equilibrium branch approaches and exchanges stability with a boundary equilibrium at infinity, providing a rigorous dynamical explanation for the transition that was identified but left unexplored in the original study. Complementing this analytical contribution, we conduct a global sensitivity analysis using Partial Rank Correlation Coefficients (PRCC), identifying macrophage proliferation, emigration, and efferocytosis as the dominant regulators of plaque dynamics. Targeted parameter investigations near <math><msub><mi>ρ</mi> <mi>c</mi></msub> </math> reveal a regulatory decoupling between macrophage accumulation and necrotic core growth, providing new biological insight into the behaviour of the model near the critical proliferation-emigration threshold.</p>","PeriodicalId":9372,"journal":{"name":"Bulletin of Mathematical Biology","volume":"88 11","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149215049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Andrei Moroianu, Miguel Pino Carmona, C. S. Shahbazi
{"title":"Torsionless three-dimensional Heterotic solitons with harmonic curvature are rigid","authors":"Andrei Moroianu, Miguel Pino Carmona, C. S. Shahbazi","doi":"10.1007/s10455-026-10065-0","DOIUrl":"10.1007/s10455-026-10065-0","url":null,"abstract":"<div><p>We prove the following rigidity result: every compact three-dimensional Heterotic soliton with vanishing torsion and harmonic curvature is rigid, namely, it is an isolated point in the moduli space.</p></div>","PeriodicalId":8268,"journal":{"name":"Annals of Global Analysis and Geometry","volume":"70 4","pages":""},"PeriodicalIF":0.8,"publicationDate":"2026-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149189821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}