工业工程最新文献

{"title":"Progress in the Metabolic Engineering of <i>Yarrowia lipolytica</i> for the Synthesis of Terpenes.","authors":"Shun-Cheng Liu, Longxing Xu, Yuejia Sun, Lijie Yuan, Hong Xu, Xiaoming Song, Liangdan Sun","doi":"10.34133/bdr.0051","DOIUrl":"https://doi.org/10.34133/bdr.0051","url":null,"abstract":"<p><p>Terpenes are natural secondary metabolites with isoprene as the basic structural unit; they are widely found in nature and have potential applications as advanced fuels, pharmaceutical ingredients, and agricultural chemicals. However, traditional methods are inefficient for obtaining terpenes because of complex processes, low yields, and environmental unfriendliness. The unconventional oleaginous yeast <i>Yarrowia lipolytica</i>, with a clear genetic background and complete gene editing tools, has attracted increasing attention for terpenoid synthesis. Here, we review the synthetic biology tools for <i>Y. lipolytica</i>, including promoters, terminators, selection markers, and autonomously replicating sequences. The progress and emerging trends in the metabolic engineering of <i>Y. lipolytica</i> for terpenoid synthesis are further summarized. Finally, potential future research directions are envisioned.</p>","PeriodicalId":56832,"journal":{"name":"生物设计研究(英文)","volume":"6 ","pages":"0051"},"PeriodicalIF":0.0,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11555184/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142633565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Levels, distribution profiles and risk assessment of chlorinated organophosphate esters in car and road dust from Basrah, Iraq","authors":"Layla Salih Al-Omran ,&nbsp;Banan Baqer Hashim ,&nbsp;William A. Stubbings ,&nbsp;Stuart Harrad","doi":"10.1016/j.emcon.2024.100435","DOIUrl":"10.1016/j.emcon.2024.100435","url":null,"abstract":"<div><div>The occurrence, concentrations, and distribution profiles of chlorinated organophosphate esters (Cl-OPEs) were investigated in seventy-one car and road dust samples collected from Basrah, southern Iraq. In addition, estimated daily intakes (EDIs) via dust ingestion were assessed for toddlers, regular adults, and taxi drivers. In car dust samples, the concentrations of Σ₃Cl-OPEs ranged from 4120 to 73200 ng/g (median 11700 ng/g) with tris (1,3-dichloroisopropyl) phosphate (TDCIPP) the predominant compound. In road dust samples, the concentrations of Σ₃Cl-OPEs ranged from 269 to 3400 ng/g (median 373 ng/g) and 114–526 ng/g (median 222 ng/g) in urban and rural areas, respectively, with tris (2-chloroisopropyl) phosphate (TCIPP), predominant. Concentrations of Cl-OPEs in urban road dust are significantly higher (<em>P</em> &lt; 0.05) than those in rural road dust, suggesting commercial and industrial activity, population density, and heavy traffic may influence the concentrations. The different compositional profiles of Cl-OPEs in car and road dust may be attributed to the physicochemical properties of Cl-OPEs and the pathways through which they can be released into indoor and outdoor environments. EDI values of Cl-OPEs for the Iraqi population via car dust ingestion were in the order: toddlers &gt; taxi drivers &gt; regular adults, exceeding those via road dust by factors of 27 and 40 from urban and rural dust, respectively. For people who work as taxi drivers, EDIs were seven times higher than those of regular adults, implying that people - such as professional drivers - who spend a substantial amount of time in their vehicles may be exposed to hazardous levels of Cl-OPEs. Despite the study showing that the EDIs through dust ingestion for the three population groups were well below the reference dose (RfD) levels, further studies are recommended to assess other pathways, such as inhalation, dietary sources, and dermal absorption.</div></div>","PeriodicalId":11539,"journal":{"name":"Emerging Contaminants","volume":"11 1","pages":"Article 100435"},"PeriodicalIF":5.3,"publicationDate":"2024-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142663870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polytetrafluoroethylene (PTFE) microplastics affect angiogenesis and central nervous system (CNS) development of duck embryo","authors":"Axll Ross A. Campos ,&nbsp;Kyan Marlu B. Luza ,&nbsp;Merrah Joy Blaya Subebe ,&nbsp;Carlito Baltazar Tabelin ,&nbsp;Theerayut Phengsaart ,&nbsp;Takahiko Arima ,&nbsp;Reya Seno ,&nbsp;Roselyn Butalid ,&nbsp;Art Brian Escabarte ,&nbsp;Ahmad Reza F. Mazahery ,&nbsp;Gloria Shiela E. Coyoca ,&nbsp;Mylah Villacorte-Tabelin","doi":"10.1016/j.emcon.2024.100433","DOIUrl":"10.1016/j.emcon.2024.100433","url":null,"abstract":"<div><div>Prolonged exposure to teratogens is known to cause neural tube defects (NTDs), a severe malformation of the central nervous system (CNS) that significantly contributes to global infant mortality. In recent years, exposure to nanoplastics (NPs) has been linked to faulty neural crest closure and altered neurulation by altering cellular adhesion molecules and accumulation of plastic particles in the neural tube leading to NTDs. However, research on the influence of various types of microplastics (MPs) on malformations of the CNS are still limited. In this study, we investigated whether MPs of polytetrafluoroethylene (PTFE)—a type of plastic commonly used as non-stick coatings of cooking utensils can affect angiogenesis and CNS development using ducks as model organisms. PTFE MPs were administered on Day 3 of duck embryo development at varying concentrations (0.01 mg/ml, 0.1 mg/ml, 1 mg/ml, and 5 mg/ml), and angiogenesis was evaluated using a chorioallantoic membrane (CAM) assay. Gross morphology and histology of the spinal column and brain were analyzed on Days 8 and 18, respectively. FTIR confirmed PTFE's structure, while SEM and DLS analyses showed particle sizes between 300 nm and 5 μm, classifying them as MPs. High concentrations (5 mg/ml) of PTFE MPs treated on duck embryos resulted in a 35 % mortality rate and reduced vascular density, suggesting anti-angiogenic effects. Brain and spinal abnormalities, such as encephalomalacia and spinal cord discontinuities were observed in the PTFE-treated embryos. Based on these results, PTFE is an anti-angiogenic and teratogenic agent affecting the development of duck embryos.</div></div>","PeriodicalId":11539,"journal":{"name":"Emerging Contaminants","volume":"11 1","pages":"Article 100433"},"PeriodicalIF":5.3,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142663866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of lead on dermal exposure of plasticizers in toys and associated risk assessment","authors":"Chaoli Yuan ,&nbsp;Mantuo Huang ,&nbsp;Jiajia wan ,&nbsp;Zijia Hong ,&nbsp;Jiwen Luo ,&nbsp;Lixuan Zeng ,&nbsp;Yu Bon Man ,&nbsp;Bingyan Lan ,&nbsp;Xiaomin Yan ,&nbsp;Yuan Kang","doi":"10.1016/j.emcon.2024.100432","DOIUrl":"10.1016/j.emcon.2024.100432","url":null,"abstract":"<div><div>Numerous studies reported risk assessment of human exposure to plasticizers in toys through dermal pathways, however, dermal bioaccessibility and percutaneous penetration of plasticizers under effects of lead had been seldom studied. In the present study, dermal bioaccessibility of plasticizers including phthalate esters and alternative plasticizers in toys were examined in artificial sweat and SSSM (synthetic sweat and sebum mixture), and percutaneous penetration of plasticizers were investigated by skin cells under individual plasticizers exposure or combined exposure conditions (plasticizers + lead). The present results indicated that dermal bioaccessibility of plasticizers in SSSM were higher than that in artificial sweat. DEHP (Di-2-ethylhexyl Phthalate) showed highest bioaccessibility among all the plasticizers, DEHT (Di (2-ethylhexyl) terephthalate) showed highest bioaccessibility among all the alternative plasticizers. DEHP and DEHT were selected to perform the cell absorption assay. Skin cell absorption assay demonstrated that MEHP (Mono-(2-ethylhexyl) phthalate) was the major metabolite of DEHP and the absorption percentage of DEHP was higher than that of DEHT. Compared to individual exposure of plasticizers, the absorption percentage of DEHP and DEHT in skin cells under the combined exposure condition were increased by 12.40 %–14.63 % and 8.35 %–9.84 %, respectively. Risk assessment indicated that the plasticizers in toy would not result in unacceptable risk for children, but the health risk of plasticizers in toys to children under combined exposure condition would be 1.5–2 times higher than that under individual exposure condition.</div></div>","PeriodicalId":11539,"journal":{"name":"Emerging Contaminants","volume":"11 1","pages":"Article 100432"},"PeriodicalIF":5.3,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142663871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The first survey of legacy and emerging per- and polyfluoroalkyl substances (PFAS) in Hulun Lake, China: Occurrence, sources, and environmental impacts","authors":"Jie Li ,&nbsp;Xinlei Li ,&nbsp;Yi Zhu ,&nbsp;Libo Wang ,&nbsp;Shilong Ren ,&nbsp;Rui An ,&nbsp;Qingzhu Zhang ,&nbsp;Guoqiang Wang","doi":"10.1016/j.emcon.2024.100431","DOIUrl":"10.1016/j.emcon.2024.100431","url":null,"abstract":"<div><div>Many per- and poly-fluoroalkyl substances (PFAS) studies in environmental media have been conducted in heavily industrialized and densely populated areas. However, there has been limited research on legacy and emerging PFAS contamination in cold and arid regions. In the present study, we investigated the concentrations of 30 PFAS compounds in the surface water and sediment of Hulun Lake and its inflowing rivers. The main components in water were short chain perfluoroalkyl carboxylic acids (PFCAs) in both Hulun Lake (33.57 %) and its inflowing rivers (30.47 %). However, long chain perfluoroalkane sulfonates (PFSAs) and long chain PFCAs accounted for more than half of the total PFAS content in sediment. Total PFAS concentrations (∑₃₀PFAS) ranged from 3.67 to 8.84 ng/L in water, and 0.97–1.73 μg/kg in sediment. Significant spatial differences were apparent between Hulun Lake and its inflowing rivers in both water and sediment samples. Source apportionment revealed that wastewater, aqueous film forming foams, textiles and paper-based food packaging, and paper products and cosmetics were the primary sources of PFAS. The partitioning coefficients of PFCAs were dependent on the carbon chain length. Temperature, conductivity, pH, salinity, chemical oxygen demand, total phosphorus (TP), total nitrogen (TN), As, and oxidation-reduction potential were the main influencing factors in water. Heavy metals (Co, Pb, Cu, Ni, Hg, Cd, and As), TP, salinity, and pH were positively correlated with the PFAS concentration in sediment. Furthermore, Hailar River contributed the majority (99.74 %, ∼15.05 kg/year) of the PFAS mass flux. This is the first study showing PFAS contamination in Hulun Lake and the results suggest that long term monitoring is needed for the effective control of PFAS pollution in this typical cold and arid region of China.</div></div>","PeriodicalId":11539,"journal":{"name":"Emerging Contaminants","volume":"11 1","pages":"Article 100431"},"PeriodicalIF":5.3,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142663865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: an exploration of enhancing thermal stability of leather by hydrophilicity regulation: effect of hydrophilicity of phenolic syntan","authors":"Qingyong Sun,&nbsp;Yunhang Zeng,&nbsp;Yue Yu,&nbsp;Ya-nan Wang,&nbsp;Bi Shi","doi":"10.1186/s42825-024-00178-2","DOIUrl":"10.1186/s42825-024-00178-2","url":null,"abstract":"","PeriodicalId":640,"journal":{"name":"Journal of Leather Science and Engineering","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://JLSE.SpringerOpen.com/counter/pdf/10.1186/s42825-024-00178-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142573742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An isogeometric analysis approach for dynamic response of doubly-curved magneto electro elastic composite shallow shell subjected to blast loading","authors":"Pham Hoang Tu ,&nbsp;Tran Van Ke ,&nbsp;Vu Khac Trai ,&nbsp;Le Hoai","doi":"10.1016/j.dt.2024.06.005","DOIUrl":"10.1016/j.dt.2024.06.005","url":null,"abstract":"<div><div>For the first time, the isogeometric analysis (IGA) approach is used to model and analyze free and forced vibrations of doubly-curved magneto-electro-elastic (MEE) composite shallow shell resting on the visco-Pasternak foundation in a hygro-temperature environment. The doubly-curved MEE shallow shell types include spherical shallow shell, cylindrical shallow shell, saddle shallow shell, and elliptical shallow shell subjected to blast load are investigated. The Maxwell equation and electromagnetic boundary conditions are used to determine the vary of the electric and magnetic potentials. The MEE shallow shell's equations of motion are derived from Hamilton's principle and refined higher-order shear theory. Then, the IGA method is used to derive the laws of natural frequencies and dynamic responses of the shell under various boundary conditions. The accuracy of the model and method is verified through reliable numerical comparisons. Aside from this, the impact of the input parameters on the free and forced vibration of the doubly-curved MEE shallow shell is examined in detail. These results may be useful in the design and manufacture of military structures such as warships, fighter aircraft, drones and missiles.</div></div>","PeriodicalId":58209,"journal":{"name":"Defence Technology(防务技术)","volume":"41 ","pages":"Pages 159-180"},"PeriodicalIF":5.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141413316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Developing a highly scalable synthetic strategy for 5-amino-4-nitrobenzo[1,2-c:3,4-c']bis([1,2,5]oxadiazole)1,b-dioxide (CL-18) and investigating the influence of crystal engineering and positional isomerization on its safety and laser ignition performance","authors":"Lei Yang,&nbsp;Zhenqi Zhang,&nbsp;Wei Du,&nbsp;Jinshan Li,&nbsp;Qing Ma","doi":"10.1016/j.dt.2024.06.008","DOIUrl":"10.1016/j.dt.2024.06.008","url":null,"abstract":"<div><div>5-amino-4-nitrobenzo[1,2-c:3,4-c']bis([1,2,5]oxadiazole)1,6-dioxide (CL-18) exhibits significant potential as an initiating explosive. However, its current synthesis process remains non-scalable due to low yields and safety risks. In this study, we have developed a simple and safe synthetic route for CL-18. It was synthesized from 3,5-dihaloanisole in a four-step reaction with an overall yield exceeding 60%, surpassing all reported yields in the literature. Subsequently, recrystallization of CL-18 was successfully achieved by carefully selecting appropriate solvents and antisolvents to reduce its mechanical sensitivity. Ultimately, when DMF-ethanol was employed as the recrystallization solvent system, satisfactory product yield (&gt;90%) and reduced mechanical sensitivity (IS = 15 J; FS = 216 N) were obtained. Additionally, CL-18 is derived from the rearrangement of oxygen atoms on i-CL-18 furoxan, and a comparative analysis of their physicochemical properties was conducted. The thermal stability of both compounds is similar, with onset decomposition temperatures recorded at 186 and 182 °C respectively. Similarly, they exhibit 5 s breaking point temperatures of 236 and 237 °C. Additionally, we present novel insights into the positional-isomerization-laser-ignition performance of CL-18 and its isomer i-CL-18 using laser irradiation for the first time. Remarkably, our findings demonstrate that i-CL-18 exhibits enhanced laser sensitivity, as it can be directly ignited by a 1064 nm wavelength laser, whereas CL-18 lacks this characteristic.</div></div>","PeriodicalId":58209,"journal":{"name":"Defence Technology(防务技术)","volume":"41 ","pages":"Pages 13-21"},"PeriodicalIF":5.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141577788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ti/WO3, a nanothermite for special purposes: An experimental study","authors":"Mateusz Polis ,&nbsp;Agnieszka Stolarczyk ,&nbsp;Konrad Szydlo ,&nbsp;Tomasz Jarosz ,&nbsp;Marcin Procek ,&nbsp;Sebastian Slawski ,&nbsp;Lukasz Hawelek","doi":"10.1016/j.dt.2024.06.010","DOIUrl":"10.1016/j.dt.2024.06.010","url":null,"abstract":"<div><div>A new nanothermite system, composed of titanium and tungsten trioxide is reported. Initial investigations show that it has low-average sensitivity to mechanical stimuli (friction, impact), but that its sensitivity to laser irradiation can be controlled in a moderately wide range. The combustion of this nanothermite system takes place at a very high apparent temperature (&gt; 3695 K) and it follows the key predictions of the established reactive sintering mechanism, as supported by SEM-EDS and XRD analyses.</div></div>","PeriodicalId":58209,"journal":{"name":"Defence Technology(防务技术)","volume":"41 ","pages":"Pages 1-12"},"PeriodicalIF":5.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141572564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modelling of internal ballistics of gun systems: A review","authors":"F. Ongaro,&nbsp;C. Robbe,&nbsp;A. Papy,&nbsp;B. Stirbu,&nbsp;A. Chabotier","doi":"10.1016/j.dt.2024.05.004","DOIUrl":"10.1016/j.dt.2024.05.004","url":null,"abstract":"<div><div>A deep understanding of the internal ballistic process and the factors affecting it is of primary importance to efficiently design a gun system and ensure its safe management. One of the main goals of internal ballistics is to estimate the gas pressure into the combustion chamber and the projectile muzzle velocity in order to use the propellant to its higher efficiency while avoiding over-pressure phenomena. Dealing with the internal ballistic problem is a complex undertaking since it requires handling the interaction between different constituents during a transient time lapse with very steep rise of pressure and temperature. Several approaches have been proposed in the literature, based on different assumptions and techniques. Generally, depending on the used mathematical framework, they can be classified into two categories: computational fluid dynamics-based models and lumped-parameter ones. By focusing on gun systems, this paper offers a review of the main contributions in the field by mentioning their advantages and drawbacks. An insight into the limitations of the currently available modelling strategies is provided, as well as some considerations on the choice of one model over another. Lumped-parameter models, for example, are a good candidate for performing parametric analysis and optimisation processes of gun systems, given their minimum requirements of computer resources. Conversely, CFD-based models have a better capacity to address more sophisticated phenomena like pressure waves and turbulent flow effects. The performed review also reveals that too little attention has been given to small calibre guns since the majority of currently available models are conceived for medium and large calibre gun systems. Similarly, aspects like wear phenomena, bore deformations or projectile-barrel interactions still need to be adequately addressed and our suggestion is to dedicate more effort on it.</div></div>","PeriodicalId":58209,"journal":{"name":"Defence Technology(防务技术)","volume":"41 ","pages":"Pages 35-58"},"PeriodicalIF":5.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141029829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}