工业工程最新文献

{"title":"Development of cinnamon essential oil-loaded Pickering emulsions stabilized by chitosan/gelatin nanoparticles with enhanced antibacterial and antibiofilm actives","authors":"Zhilang Xu,&nbsp;Xinxin Wang,&nbsp;Huaqian Liang,&nbsp;Xinying Li,&nbsp;Derong Li,&nbsp;Changdao Mu,&nbsp;Liming Ge,&nbsp;Defu Li","doi":"10.1186/s42825-024-00180-8","DOIUrl":"10.1186/s42825-024-00180-8","url":null,"abstract":"<div><p>Bacterial biofilm infection is a complicated and important global problem. Non-toxic biomass-based Pickering emulsions as an essential oil delivery system are a potentially effective means in biofilm treatment. Herein, the chitosan/gelatin complex nanoparticles (CGNPs) stabilized Pickering (CGP) emulsion loaded with <i>cinnamon essential oil</i> (CEO) was developed to inhibit and remove bacterial biofilms. CGNPs were initially successfully prepared with a particle size of 253.7 nm. Subsequently, CGP emulsions were prepared using CGNPs as the emulsifier and CEO as the oil phase, with the aqueous phase pH value of 5.5 and ionic strength of 50 mM. Amino groups of CGNPs were crosslinked with the aldehyde group of CEO via Schiff base reaction at the oil–water interface to form a denser core–shell structure, thus improving the stability of Pickering emulsion. The CGP emulsions exhibit controlled and long-term sustained release properties in essential oil delivery, with 89.8%, 81.0%, and 62.2% CEO release within 168 h for CGP-0.1, CGP-0.2, and CGP-0.3, respectively. Moreover, CGP emulsions have stronger antioxidant activities (nearly 100%), broad-spectrum antibacterial activities (&gt; 90%), enhanced penetration and removal capabilities against preformed biofilms than single CEO or CGNPs, as well as its better biocompatibility than conventional surfactant-stabilized emulsions. Hence, CEO-delivered CGP emulsion could serve as a potential strategy against biofilm infections and bacterial resistance.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":640,"journal":{"name":"Journal of Leather Science and Engineering","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://JLSE.SpringerOpen.com/counter/pdf/10.1186/s42825-024-00180-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142912806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel recycling technology for chrome shavings: efficient separation of chromium and collagen fibers based on swelling inhibition in alkali-acid processing","authors":"Honghong Chen,&nbsp;Minghui Li,&nbsp;Sadaqat Ali Chattha,&nbsp;Xu Zhang,&nbsp;Biyu Peng,&nbsp;Chunxiao Zhang","doi":"10.1186/s42825-024-00182-6","DOIUrl":"10.1186/s42825-024-00182-6","url":null,"abstract":"<div><p>Dechroming techniques with a low degree of collagen hydrolysis and a high degree of dechroming are more suitable for the resource utilization of chrome shavings. However, achieving efficient simultaneous separation of chromium and collagen fibers is challenging because swollen collagen fibers absorb a large amount of chromium-containing water and are prone to hydrolysis after dechroming. This study investigated the correlation between the swelling inhibition of collagen fibers and the extent of dechroming and optimized the process parameters. The results demonstrated that the incorporation of neutral salt significantly increased the rate of dechroming and reduced the degree of collagen hydrolysis. The optimized alkali-acid-washing process was as follows: soaking in a Na₂SO₄ solution (4%, w/w), dechroming with a NaOH solution at pH 13.5, rapidly adjusting the pH of reactants to 1.0 with an H₂SO₄ solution, pressure filtration, washing the filtered residue with 5% Na₂SO₄ solution (w/w) at pH 1.0, followed by pressure filtration. After two cycles of the alkali-acid-washing process, the filtered residue was washed with an oxalic acid-Na₂SO₄ solution (5%, w/w) and pressure-filtered again. The chromium content of recovered collagen was reduced to 34.0 mg/kg. The degree of collagen hydrolysis was confined to 9% with the fiber morphology completely retained. The wastewater chromium content was reduced to 0.4 mg/L after the simple precipitation, meeting the direct discharge requirement. The recycled chrome was utilized as chrome-tanning agent. These results suggested that the established method could be a promising resource reutilization route for the sustainable development of the leather industry.</p><h3>Graphical abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":640,"journal":{"name":"Journal of Leather Science and Engineering","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://JLSE.SpringerOpen.com/counter/pdf/10.1186/s42825-024-00182-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142912811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The study on multi-defect detection for leather using object detection techniques","authors":"Hasan Onur Ataç,&nbsp;Ahmet Kayabaşı,&nbsp;M. Fatih Aslan","doi":"10.1186/s42825-024-00186-2","DOIUrl":"10.1186/s42825-024-00186-2","url":null,"abstract":"<div><p>Leather has played a very important role in human life for thousands of years. Ensuring the quality of leather and addressing surface defects poses significant challenges. Traditionally, human inspectors are responsible for detecting surface defects in tanneries, but this approach is labor-intensive and susceptible to human error. As a result, there is a growing demand for automated systems to detect the defects. Herein, artificial intelligence (AI) was developed to detect the defects on leather surfaces. Six targeted defect types, denoted as insect bites, scratches, holes, stitch marks, diseased and ruptures, were specifically addressed to enhance the overall quality assessment process. AI-based vision techniques were used to detect flaws on the leather on photographs taken with a high-resolution camera. Deep learning algorithms Mask R-CNN, YOLOv8 and within the framework of Detectron2, RetinaNet R101 3x, Faster R-CNN R101-FPN 3x models were performed and a comparison was made between these algorithms. By using the slicing aided hyper-inference (SAHI) algorithm in coordination with these algorithms, the detection rates of small defects on the images were increased. The highest accuracy rate was achieved when the YOLOv8 algorithm had 75 epoch values for training, and the SAHI algorithm had slice height-width values of 256 × 256 pixels.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":640,"journal":{"name":"Journal of Leather Science and Engineering","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://JLSE.SpringerOpen.com/counter/pdf/10.1186/s42825-024-00186-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142906064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research Progress on Obesity-Associated Kidney Diseases.","authors":"Rui-Feng Yang, Wen Wu, Peng Zhang","doi":"10.3881/j.issn.1000-503X.16098","DOIUrl":"https://doi.org/10.3881/j.issn.1000-503X.16098","url":null,"abstract":"<p><p>The pathogenesis of obesity-associated kidney disease (OAKD) involves many aspects,including the overactivation of the renin-angiotensin-aldosterone system,insulin resistance,chronic inflammation,disorder of lipid metabolism and imbalance of gut microecology.Treatment strategies for OAKD focus on lifestyle adjustments,pharmacotherapy,bariatric surgery,and fecal microbiota transplantation.A deeper understanding of the hazards of OAKD and its pathogenesis will contribute to the development of personalized and precise strategies for prevention,diagnosis and treatment of OAKD in the future.</p>","PeriodicalId":6919,"journal":{"name":"中国医学科学院学报","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142891337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Association between <i>ADCY3</i> gene polymorphism and the effects of high-intensity interval training on body composition].","authors":"Jun-Ren Lai, Li Gong, Yan Liu, Yan-Chun Li, Jing Nie, Duo-Qi Zhou","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This study aimed to analyze the impact of single nucleotide polymorphism (SNP) of <i>ADCY3</i> (encoding adenylate cyclase 3) on the outcome of high-intensity interval training (HIIT) on body composition and screen genetic markers sensitive to HIIT in Chinese Han youth. A total of 237 non-regular exercise Han college students were recruited in a 12-week HIIT program, attending sessions 3 times a week. Before and after the HIIT program, their body composition was measured. DNA from the white blood cells was extracted and genotyped. PLINK (V1.09) software was used for quality control screening of SNPs loci, and a linear regression model was constructed to analyze the association between <i>ADCY3</i> gene SNPs loci and body composition. ANOVA multiple comparisons (LSD) were performed to test the difference between groups, with the significance level set at 0.05. The results showed that: 1) A total of 22 SNPs loci were identified by the gene microarray scanning of <i>ADCY3</i> gene, with 15 of them meeting the quality control criteria. The rs6753096 locus was associated with the training effect of HIIT on body composition; 2) The rs6753096 locus was not associated with pre-HIIT body composition; 3) Compared with volunteers with TT genotype, those with CT/CC genotype exhibited significant decrease in body mass index (BMI) and total body fat after training (<i>P</i> < 0.05); Male volunteers carrying the C allele had more significant training changes in skeletal muscle and lean body weight, while HIIT was more effective in decreasing body fat in female volunteers with CT/CC genotype; 4) The rs6753096 locus was significantly correlated with body fat sensitivity to HIIT (<i>P</i> = 0.0475), indicating that volunteers with CT/CC genotype were more sensitive to HIIT. In conclusion, 12-week HIIT program effectively improved the body composition of college students. The <i>ADCY3</i> gene rs6753096 locus is not associated with pre-HIIT body composition, but it is associated with body composition sensitivity to HIIT, with individuals carrying CT/CC genotype showing greater responsiveness to HIIT.</p>","PeriodicalId":7134,"journal":{"name":"生理学报","volume":"76 6","pages":"970-978"},"PeriodicalIF":0.0,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142942495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Research progress of fetuin-B in the female reproductive system].","authors":"Xiao Wang, Hong-Yan Lyu, De-Quan Chen, Bo Chang, Ting-Ting Yao","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Fetuin-B (FETUB) is a glycoprotein mainly synthesized and secreted by the liver. It is involved in many physiological and pathological processes including glucose metabolism, inflammatory response, nonalcoholic fatty liver disease, myocardial infarction, tumor and so on. In recent years, FETUB has also been confirmed to play roles in the female reproductive system. FETUB may affect follicular development and play an important role in <i>in vivo</i> and <i>in vitro</i> fertilization. In addition, serum FETUB level is elevated significantly during pregnancy and labor. FETUB expression is changed in a variety of reproductive diseases (polycystic ovary syndrome, gestational diabetes mellitus, intrahepatic cholestasis of pregnancy). In this review, we summarize FETUB related studies in female reproduction, and focus on the roles of FETUB in female reproductive physiology and pathology, in order to provide information for the pathogenesis of reproductive disorders.</p>","PeriodicalId":7134,"journal":{"name":"生理学报","volume":"76 6","pages":"1019-1031"},"PeriodicalIF":0.0,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142942521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Expert consensus on ethical requirements for artificial intelligence (AI) processing medical data].","authors":"Cong Li, Xiao-Yan Zhang, Yun-Hong Wu, Xiao-Lei Yang, Hua-Rong Yu, Hong-Bo Jin, Ying-Bo Li, Zhao-Hui Zhu, Rui Liu, Na Liu, Yi Xie, Lin-Li Lyu, Xin-Hong Zhu, Hong Tang, Hong-Fang Li, Hong-Li Li, Xiang-Jun Zeng, Zai-Xing Chen, Xiao-Fang Fan, Yan Wang, Zhi-Juan Wu, Zun-Qiu Wu, Ya-Qun Guan, Ming-Ming Xue, Bin Luo, Ai-Mei Wang, Xin-Wang Yang, Ying Ying, Xiu-Hong Yang, Xin-Zhong Huang, Ming-Fei Lang, Shi-Min Chen, Huan-Huan Zhang, Zhong Zhang, Wu Huang, Guo-Biao Xu, Jia-Qi Liu, Tao Song, Jing Xiao, Yun-Long Xia, You-Fei Guan, Liang Zhu","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>As artificial intelligence technology rapidly advances, its deployment within the medical sector presents substantial ethical challenges. Consequently, it becomes crucial to create a standardized, transparent, and secure framework for processing medical data. This includes setting the ethical boundaries for medical artificial intelligence and safeguarding both patient rights and data integrity. This consensus governs every facet of medical data handling through artificial intelligence, encompassing data gathering, processing, storage, transmission, utilization, and sharing. Its purpose is to ensure the management of medical data adheres to ethical standards and legal requirements, while safeguarding patient privacy and data security. Concurrently, the principles of compliance with the law, patient privacy respect, patient interest protection, and safety and reliability are underscored. Key issues such as informed consent, data usage, intellectual property protection, conflict of interest, and benefit sharing are examined in depth. The enactment of this expert consensus is intended to foster the profound integration and sustainable advancement of artificial intelligence within the medical domain, while simultaneously ensuring that artificial intelligence adheres strictly to the relevant ethical norms and legal frameworks during the processing of medical data.</p>","PeriodicalId":7134,"journal":{"name":"生理学报","volume":"76 6","pages":"937-942"},"PeriodicalIF":0.0,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142942506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Research progress on molecular mechanism related to skeletal muscle atrophy].","authors":"Yi-Bing Ke, Dawuti Abudoukeremu, Hao-Ran Guo, Yong-Ping Wang","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The maintenance of skeletal muscle quality involves various signal pathways that interact with each other. Under normal physiological conditions, these intersecting signal pathways regulate and coordinate the hypertrophy and atrophy of skeletal muscles, balancing the protein synthesis and degradation of muscle. When the total rate of protein synthesis exceeds that of protein degradation, the muscle gradually becomes enlarged, while when the total rate of protein synthesis is lower than that of protein degradation, the muscle shrinks. Myocyte atrophy mainly involves two protein degradation pathways, namely ubiquitin-proteasome and autophagy-lysosome. Protein degradation pathway is activated during muscle atrophy, resulting in the loss of muscle mass. Muscle atrophy can occur under various conditions such as malnutrition, aging and cachexia. Skeletal muscle atrophy caused by orthopedic diseases mainly includes disuse muscular atrophy caused by fracture and denervation muscular atrophy. The signal pathways that control and coordinate protein synthesis and degradation in skeletal muscle include insulin-like growth factor 1 (IGF1)-Akt-mammalian target of rapamycin (mTOR), myostatin-activin A-Smad, G protein α inhibitory peptide 2 (Gαi2)-PKC, nuclear factor κB (NF-κB), ectodysplasin A2 receptor (EDA2R)-NF-κB inducing kinase (NIK) and mitogen-activated protein kinase (MAPK) pathways. This paper provides a comprehensive review of the protein degradation pathways in skeletal muscle atrophy and the associated signal pathways regulating protein degradation in muscular atrophy.</p>","PeriodicalId":7134,"journal":{"name":"生理学报","volume":"76 6","pages":"1056-1068"},"PeriodicalIF":0.0,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142942527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Revisiting the vasopressin V2 receptor].","authors":"Meng Li, Wei-Dong Wang, Chun-Ling Li","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Arginine vasopressin (AVP) plays a crucial role in various physiological processes including water reabsorption, cardiovascular homeostasis, hormone secretion, and social behavior. AVP acts through three distinct receptor subtypes, i.e., V1a, V1b, and V2. Among them, the vasopressin V2 receptor (V2R) was initially discovered in the principal cells of renal collecting ducts, where it is primarily involved in regulating water reabsorption. However, in recent years, with the advancement of imaging and bioinformatics techniques, there has been a deeper understanding of the microstructure, protein binding capacity, and specific tissue distribution of V2R. Additionally, the pathogenic roles and target effects of V2R in various diseases have been uncovered through ectopic overexpression, activation, or antagonism. This paper aims to provide a brief overview of current research status on the physiological functions, pathophysiological mechanisms, and drug development related to V2R in recent years.</p>","PeriodicalId":7134,"journal":{"name":"生理学报","volume":"76 6","pages":"893-907"},"PeriodicalIF":0.0,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142942533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[NMDA receptors in prelimbic cortex neurons projecting to paraventricular nucleus of the thalamus are associated with morphine withdrawal memory retrieval].","authors":"Chen-Shan Chu, Ya-Xian Wen, Qian-Ru Shen, Bin Lai, Ming Chen, Ping Zheng","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>At present, the problem of drug addiction treatment mainly lies in the high relapse rate of drug addicts. Addictive drugs will bring users a strong sense of euphoria and promote drug seeking. Once the drug is withdrawn, there will be withdrawal symptoms such as strong negative emotions and uncomfortable physical reactions. The recurrence of context-induced withdrawal memory is an important reason for drug relapse. Our previous study has shown increased c-Fos expression in prelimbic cortex (PrL) neurons projecting to paraventricular nucleus of the thalamus (PVT) (PrL^-PVT) during conditioned context-induced retrieval of morphine withdrawal memory. However, whether PrL^-PVT neurons are involved in withdrawal memory retrieval and the underlying molecular mechanisms remain unknown. In this study, we used conditioned place aversion (CPA) model combined with <i>in vivo</i> calcium signal recording, chemogenetics and nucleus drug injection methods to investigate the role and molecular mechanism of PrL^-PVT neurons in retrieval of morphine withdrawal memory. The results showed that the calcium signals of PrL^-PVT neurons were significantly enhanced by withdrawal-related context; Inhibition of PrL^-PVT neurons blocked the conditioned context-induced morphine withdrawal memory retrieval; Activation of PrL^-PVT neurons caused animals to escape from the context; After the inhibition of NMDA receptors in the PrL, withdrawal-related context failed to increase c-Fos and Arc expressions in PrL^-PVT neurons. The above results suggest that NMDA receptors in PrL^-PVT neurons are associated with retrieval of morphine withdrawal memory. This study is of great significance for further understanding the neural circuit mechanism of withdrawal memory retrieval as well as the intervention and prevention of drug relapse.</p>","PeriodicalId":7134,"journal":{"name":"生理学报","volume":"76 6","pages":"917-926"},"PeriodicalIF":0.0,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142942512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}