中国医学科学院学报 Pub Date : 2026-02-01 DOI: 10.3881/j.issn.1000-503X.16908

Lin-Ling Shen, Jing-Lin Zhao, Shan Zhang, Jun-E Liu, Peng Yue

{"title":"Current Situation of Construction and Implementation of Hospice Care System in Beijing.","authors":"Lin-Ling Shen, Jing-Lin Zhao, Shan Zhang, Jun-E Liu, Peng Yue","doi":"10.3881/j.issn.1000-503X.16908","DOIUrl":"10.3881/j.issn.1000-503X.16908","url":null,"abstract":"Objective To examine the progress in incorporating hospice care as a key component to improve the quality of life for the elderly within Beijing's city-wide elderly health support system. Methods Relevant policy documents and literature,as well as the progress in system construction and service model development of hospice care in Beijing,were reviewed to comprehensively evaluate the effects and challenges of policy implementation. Results Guided by national policies,Beijing has advanced hospice care through innovative service models that integrate hospital,community,and home-based care,supported by \"Internet+\" technologies to enhance service accessibility and efficiency.Multiple healthcare institutions have established hospice care departments and adopted multidisciplinary team approaches to improve service quality.In addition,progress has also been made in workforce training,digital infrastructure,and supportive socio-economic policies. Conclusions While Beijing has achieved initial success in developing a hospice care system,challenges remain,including uneven resource distribution and a shortage of qualified professionals.Further efforts are needed to optimize resource allocation,strengthen professional training,enhance public awareness,and improve digital support.These efforts are expected to promote the building of a comprehensive and sustainable hospice care system that ensures dignity and compassion for the elderly at the end of life.This study has for the first time constructed a gradient allocation model of palliative care resources,providing a reference for developing countries.","PeriodicalId":6919,"journal":{"name":"中国医学科学院学报","volume":"48 1","pages":"81-89"},"PeriodicalIF":0.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147508688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Precursor B-Cell Acute Lymphoblastic Leukemia With PICALM∶∶MLLT10 Fusion Gene Positivity:Report of One Case and Literature Review. PICALM∶∶MLLT10融合基因阳性前体b细胞急性淋巴细胞白血病1例报告并文献复习

中国医学科学院学报 Pub Date : 2026-02-01 DOI: 10.3881/j.issn.1000-503X.16685

Jie-Jun Zhao, Qian-Min Zeng, Li-Na Wang, Ming Li, Ya-Ming Xi

引用次数: 0

Conception of the Discipline Construction of Palliative Medicine(Continued). 姑息医学学科建设构想（续）。

中国医学科学院学报 Pub Date : 2026-02-01 DOI: 10.3881/j.issn.1000-503X.16901

Fei Li, Zhong He, Jia-Xin Zhou, Xi Ding, Jun-Li Guo, Xiao-Hong Ning

引用次数: 0

Huge Exogenous Pelvic Endometrial Stromal Sarcoma Penetrating the Cervix:Report of One Case. 巨大外源性骨盆子宫内膜间质肉瘤侵彻宫颈1例报告。

中国医学科学院学报 Pub Date : 2026-02-01 DOI: 10.3881/j.issn.1000-503X.16526

Zhen-Ru Lu, Ting Wang

引用次数: 0

Clinical Application and Research Progress of ¹⁸F-FDG PET/CT Radiomics in Non-Small Cell Lung Cancer. 18F-FDG PET/CT放射组学在非小细胞肺癌中的临床应用及研究进展

中国医学科学院学报 Pub Date : 2026-02-01 DOI: 10.3881/j.issn.1000-503X.16600

Wei Liu, Jun Wang

引用次数: 0

Exploration of Life Education Methods in Medical Colleges and Universities: Experiential Teaching of Hospice Care. 医学院校生命教育方法的探索：临终关怀体验式教学。

中国医学科学院学报 Pub Date : 2026-02-01 DOI: 10.3881/j.issn.1000-503X.16653

Yong-Qing Han, Zhong He, Xiao-Hong Ning, Jia-Xin Zhou, Ming-Hui Wang, Ling-Ling Wu, Fei Li

引用次数: 0

Roles of Three Epstein-Barr Virus Antibodies in the Screening of Nasopharyngeal Carcinoma. 三种eb病毒抗体在鼻咽癌筛查中的作用。

中国医学科学院学报 Pub Date : 2026-02-01 DOI: 10.3881/j.issn.1000-503X.16578

Sha Qin, Yue-Xiang Qin, Xu-Peng Zhang, Xiang-Yuan Meng, Shan-Hu Yao, Yun-Sheng Chen, Yu-Yang Xiao

{"title":"Roles of Three Epstein-Barr Virus Antibodies in the Screening of Nasopharyngeal Carcinoma.","authors":"Sha Qin, Yue-Xiang Qin, Xu-Peng Zhang, Xiang-Yuan Meng, Shan-Hu Yao, Yun-Sheng Chen, Yu-Yang Xiao","doi":"10.3881/j.issn.1000-503X.16578","DOIUrl":"https://doi.org/10.3881/j.issn.1000-503X.16578","url":null,"abstract":"Objective To investigate the association between Epstein-Barr virus(EBV)and nasopharyngeal carcinoma(NPC)and to evaluate the roles of EBV antibodies Rta-IgG,VCA-IgA,and EA-IgA in the screening of NPC. Methods The related literature was retrieved from the Web of Science Core Collection.The publication output,keyword co-occurrence,and country/region collaboration were analyzed with VOSviewer,CiteSpace,and Excel.A total of 402 NPC patients,915 individuals with nasal symptoms,and 27 395 healthy participants undergoing physical examination in Xiangya Hospital,The Second Xiangya Hospital,and The Third Xiangya Hospital were enrolled.Serum Rta-IgG,VCA-IgA,and EA-IgA levels were measured by ELISA,and their diagnostic performance for NPC was assessed by receiver operating characteristic curves.Inter-group differences were compared through the χ2 test. Results The research on EBV-NPC was highly productive.The top three keywords by frequency were nasopharyngeal carcinoma,Epstein-Barr virus,and cancer.China was the leading contributor.In the NPC cohort,the diagnostic sensitivities of Rta-IgG,VCA-IgA,and EA-IgA were 76.12%,83.58%,and 62.19%,respectively,which were higher than those in the other two groups(all P<0.001).VCA-IgA showed the highest sensitivity(83.58%),whereas EA-IgA exhibited the best specificity(97.41%).The three antibodies showed high negative prediction values,which were 99.65%,99.76%,and 99.45%.Combined testing of Rta-IgG,VCA-IgA,and EA-IgA increased the sensitivity to 99.50%. Conclusions The EBV-NPC link remains a major research focus.Serum Rta-IgG,VCA-IgA,and EA-IgA levels are clinically valuable for NPC diagnosis,and their combined detection significantly improves the screening efficiency.","PeriodicalId":6919,"journal":{"name":"中国医学科学院学报","volume":"48 1","pages":"113-119"},"PeriodicalIF":0.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147508806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Expert Consensus on Ethical Governance for Clinical Applications of Generative Medical Artificial Intelligence(2025 Edition). 生成医学人工智能临床应用伦理治理专家共识（2025年版）。

中国医学科学院学报 Pub Date : 2026-02-01 DOI: 10.3881/j.issn.1000-503X.17220

Meng-Chun Gong, Yong-Hui Ma, Hui Pan, Hua Bai, Hui Dai, Wei Chen, Hui Liu, Kai Gong, Zhi-Rong Zeng, Hao Wu, Yun Zhou, Zi-Hao Ouyang, Yan Luo, Bo-Han Zhang, Jun-Rong Liu, Xun-Ming Ji

{"title":"Expert Consensus on Ethical Governance for Clinical Applications of Generative Medical Artificial Intelligence(2025 Edition).","authors":"Meng-Chun Gong, Yong-Hui Ma, Hui Pan, Hua Bai, Hui Dai, Wei Chen, Hui Liu, Kai Gong, Zhi-Rong Zeng, Hao Wu, Yun Zhou, Zi-Hao Ouyang, Yan Luo, Bo-Han Zhang, Jun-Rong Liu, Xun-Ming Ji","doi":"10.3881/j.issn.1000-503X.17220","DOIUrl":"10.3881/j.issn.1000-503X.17220","url":null,"abstract":"The research and innovative applications of generative medical artificial intelligence(GMAI)are rapidly advancing in the healthcare field.Significant breakthroughs of GMAI have been achieved in areas such as generating diagnostic suggestions,optimizing treatment plans,and assisting doctor-patient communication,profoundly reshaping the paradigm of clinical diagnosis and treatment.However,the open-ended nature of GMAI's generation raises novel ethical challenges,including algorithmic bias,ambiguous accountability,data privacy breaches,and insufficient cultural adaptability.Current ethical governance lags behind technological implementation,necessitating the establishment of a standardized governance framework.Our research team assembled a multidisciplinary panel of experts spanning medical ethics,clinical medicine,medical artificial intelligence,hospital management,public health,and law.According to the governance logic of \"prevention-control-remediation\" and integrating international norms with domestic policies,this consensus was developed through two rounds of expert consultation to unify opinions and perspectives.It aims to provide a reference for the specific practice of clinical ethical review in the research and clinical application of GMAI and to establish an authoritative guidance framework for the clinical ethical governance of GMAI,tailored to China's cultural context and national requirements.","PeriodicalId":6919,"journal":{"name":"中国医学科学院学报","volume":" ","pages":"24-37"},"PeriodicalIF":0.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146155676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Research Progress on Adriamycin-Induced Myocardial Injury: Pathological Mechanism and Animal Model. 阿霉素致心肌损伤的病理机制及动物模型研究进展。

中国医学科学院学报 Pub Date : 2026-02-01 DOI: 10.3881/j.issn.1000-503X.16565

Xuan-Yi Tao, Fang-Fang Xu, Qi-Rui Shen, Yu-Xin Chen, Hui Fu

引用次数: 0

A Novel Carrier-Free Spherical Nanomedicine for Acute Myeloid Leukemia. 一种新型无载体球形纳米药物治疗急性髓系白血病。

中国医学科学院学报 Pub Date : 2026-02-01 DOI: 10.3881/j.issn.1000-503X.16624

You-Peng Kong, Dan Liu, Bo Deng, Ying-Ying Ma, Yi-Jie Zhan, Ru-Dan Wang, Yi-Tong Sun, Jia-le Liu, Lan-Xia Liu

{"title":"A Novel Carrier-Free Spherical Nanomedicine for Acute Myeloid Leukemia.","authors":"You-Peng Kong, Dan Liu, Bo Deng, Ying-Ying Ma, Yi-Jie Zhan, Ru-Dan Wang, Yi-Tong Sun, Jia-le Liu, Lan-Xia Liu","doi":"10.3881/j.issn.1000-503X.16624","DOIUrl":"https://doi.org/10.3881/j.issn.1000-503X.16624","url":null,"abstract":"Objective To develop a novel carrier-free spherical nanomedicine with daunorubicin(DNR)for combined chemotherapy of leukemia and systematically study its physicochemical properties,drug release behavior,and in vitro and in vivo therapeutic efficacy. Methods DNR was chemically conjugated with 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine(DOPE)for the self-assembly of nanoparticles,which were further loaded with cytarabine(Ara-C)to form DOPE-DNR Ara-C nanomedicine(DDA NPs)for combined chemotherapy of acute myeloid leukemia.The particle size and surface potential of DDA NPs were characterized by dynamic light scattering and zeta potential analysis.The drug release behavior in high-concentration glutathione(GSH)was studied through reduction-responsive drug release experiments.In vitro cytotoxicity assays were conducted to evaluate the inhibitory effect on leukemia cells,while a rat model of leukemia was used to assess the antitumor efficacy in vivo. Results DDA NPs exhibited a spherical nanostructure with a particle size of(123.67±0.11)nm and the zeta potential of(-25.60±0.67)mV,showing good stability under physiological conditions.High-concentration GSH effectively triggered disulfide bond cleavage,facilitating targeted drug release.In vitro,DDA NPs significantly enhanced drug accumulation in the nuclei of LT-12 leukemia cells and improved the cytotoxicity of DNR.The animal experiment showed that compared with free drugs,DDA NPs significantly reduced the number of leukemia cells in rat bone marrow,prolonged the survival,and effectively inhibited leukemia cell infiltration while alleviating organ damage. Conclusions DDA NPs as a novel carrier-free nanomedicine significantly enhanced drug delivery efficiency and synergistic therapeutic effects.It demonstrates good clinical translation potential and may provide a new therapeutic strategy for the treatment of acute myeloid leukemia.","PeriodicalId":6919,"journal":{"name":"中国医学科学院学报","volume":"48 1","pages":"101-112"},"PeriodicalIF":0.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147508700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

中国医学科学院学报最新文献