中国医学科学院学报最新文献

{"title":"[Laser-Assisted Pulp Revascularization Therapy for Periapical Periodontitis in an Adult with an Immature Root:Report of One Case].","authors":"Zhen Li, Shan-Shan Ding, Yan Xie, Xiao-Wei Zhang, You-Jia Tang, Qian Li","doi":"10.3881/j.issn.1000-503X.16703","DOIUrl":"https://doi.org/10.3881/j.issn.1000-503X.16703","url":null,"abstract":"<p><p>The conventional treatment for periapical periodontitis faces challenges,especially in the cases with immature roots.This article reports a case of periapical periodontitis in an adult permanent tooth with an immature root,where erbium-doped yttrium aluminum garnet(Er:YAG)laser-activated root canal disinfection was employed to induce apical bleeding and pulp revascularization.A 22-month postoperative follow-up showed healing of the periapical lesion,narrowing of the apical foramen,and positive pulp vitality test results.</p>","PeriodicalId":6919,"journal":{"name":"中国医学科学院学报","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144774461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Clinical and Ultrasound Manifestations of Immune Checkpoint Inhibitor-Associated Enterocolitis:Report of One Case].","authors":"Xiao-Yan Zhang, Jing Qin, Xiao-Qing Li, Guan-Nan Zhang, Wen-Bo Li","doi":"10.3881/j.issn.1000-503X.16799","DOIUrl":"https://doi.org/10.3881/j.issn.1000-503X.16799","url":null,"abstract":"<p><p>Immune checkpoint inhibitor-associated enterocolitis is an immune-related adverse reaction during tumor treatment with immune checkpoint inhibitors(such as PD-1/PD-L1 inhibitors and CTLA-4 inhibitors).In this article,we present the clinical data and ultrasound manifestations of a patient with immune checkpoint inhibitor-associated enterocolitis,aiming to share diagnostic and therapeutic insights.</p>","PeriodicalId":6919,"journal":{"name":"中国医学科学院学报","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144774460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Clinical and Intestinal Ultrasound Findings in Mitochondrial Neurogastrointestinal Encephalomyopathy:Report of One Case].","authors":"Xiao-Yan Zhang, Qing-Li Zhu, Ge-Chong Ruan, Wen-Bo Li","doi":"10.3881/j.issn.1000-503X.16801","DOIUrl":"https://doi.org/10.3881/j.issn.1000-503X.16801","url":null,"abstract":"<p><p>Mitochondrial neurogastrointestinal encephalomyopathy(MNGIE),a rare mitochondrial disorder caused by TYMP gene mutations,is characterized by severe gastrointestinal dysmotility,peripheral neuropathy,and leukodystrophy.This article summarizes the clinical data and intestinal ultrasound findings of a MNGIE case,aiming to provide insights for clinical diagnosis and treatment.</p>","PeriodicalId":6919,"journal":{"name":"中国医学科学院学报","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144774459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Health Failure Mode and Effect Analysis in Optimizing the Management Process of Postoperative Diabetes Insipidus in Children Undergoing Neurosurgery.","authors":"Hui-Yun Zhao, Xiao-Ying Xu, Bo Wu, Shi Tang, Xin-Meng Li","doi":"10.3881/j.issn.1000-503X.16410","DOIUrl":"10.3881/j.issn.1000-503X.16410","url":null,"abstract":"<p><p>Objective To investigate the effect of health failure mode and effect analysis(HFMEA)in optimizing the management process of postoperative diabetes insipidus in children undergoing neurosurgery.Methods Based on HFMEA,a management flowchart for postoperative diabetes insipidus in children undergoing neurosurgery was created.Brainstorming was adopted to identify failure modes in the workflow,analyze risk factors,and develop improvement measures,thereby refining the management flowchart.The amelioration and prognosis of diabetes insipidus in these children before(October 2022 to November 2023)and after(January 2024 to February 2025)implementation of the management flowchart were compared.Results The HFMEA-based management process for postoperative diabetes insipidus in children undergoing neurosurgery alleviated the symptoms of diabetes insipidus regarding the number of diabetes insipidus in the pediatric intensive care unit(<i>P</i>=0.006),the average daily urine output in the pediatric intensive care unit(<i>P</i>=0.001),the proportion of electrolyte abnormalities at discharge/transfer(<i>P</i>=0.037),the duration of mechanical ventilation(<i>P</i>=0.007),and the length of stay in the intensive care unit(<i>P</i>=0.001).Conclusion The HFMEA-based management process for postoperative diabetes insipidus in children undergoing neurosurgery is beneficial to the optimization of the management process,the alleviation of postoperative diabetes insipidus,and the improvement of prognosis in these children.</p>","PeriodicalId":6919,"journal":{"name":"中国医学科学院学报","volume":"47 4","pages":"582-589"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145063245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression and Clinical Significance of Class Ⅰ Histone Deacetylases in the Serum of Patients With Psoriatic Arthritis.","authors":"Ming-Hui Zhang, Wen-Xiu Dong, Jia Wang, Gai-Lian Zhang","doi":"10.3881/j.issn.1000-503X.16499","DOIUrl":"10.3881/j.issn.1000-503X.16499","url":null,"abstract":"&lt;p&gt;&lt;p&gt;Objective To investigate the expression levels of class Ⅰ histone deacetylases(HDAC)in the serum of patients with newly diagnosed psoriatic arthritis(PsA)and screen out serological indicators that are of significance for early diagnosis and assessment of disease activity.Methods A total of 49 PsA patients newly diagnosed in Shanxi Provincial People's Hospital from August 2022 to February 2024 and 30 healthy individuals(control group)were enrolled in this study.Demographic data were collected,and disease severity was assessed.Serum samples were collected,and the expression levels of class Ⅰ HDAC(HDAC1,HDAC2,HDAC3,and HDAC8)in the serum of each group were determined by ELISA.The correlations between the expression levels of class Ⅰ HDAC and clinical assessment indicators in each group were evaluated.Multivariate Logistic regression was adopted to analyze the risk factors affecting the disease activity of PsA patients.The receiver operating characteristic curve was used to evaluate the diagnostic efficacy of the risk factors affecting the disease activity of PsA patients.Results Compared with the control group,PsA patients showed up-regulated expression levels of HDAC1(&lt;i&gt;P&lt;/i&gt;=0.003),HDAC2(&lt;i&gt;P&lt;/i&gt;=0.010),HDAC3(&lt;i&gt;P&lt;/i&gt;=0.003),and HDAC8(&lt;i&gt;P&lt;/i&gt;=0.018)in the serum.The serum HDAC1 level of PsA patients was positively correlated with erythrocyte sedimentation rate(&lt;i&gt;r&lt;/i&gt;=0.344,&lt;i&gt;P&lt;/i&gt;=0.028).The serum HDAC2 level was positively correlated with the overall assessment of disease activity(&lt;i&gt;r&lt;/i&gt;=0.468,&lt;i&gt;P&lt;/i&gt;=0.001),the disease activity index of arthritis(&lt;i&gt;r&lt;/i&gt;=0.401,&lt;i&gt;P&lt;/i&gt;=0.007),the number of swollen joints(&lt;i&gt;r&lt;/i&gt;=0.308,&lt;i&gt;P&lt;/i&gt;=0.042),hospital anxiety and depression scale(HADS)score of anxiety(&lt;i&gt;r&lt;/i&gt;=0.360,&lt;i&gt;P&lt;/i&gt;=0.018),and HADS score of depression(&lt;i&gt;r&lt;/i&gt;=0.302,&lt;i&gt;P&lt;/i&gt;=0.047).The serum HDAC3 level was correlated with erythrocyte sedimentation rate(&lt;i&gt;r&lt;/i&gt;=0.542,&lt;i&gt;P&lt;/i&gt;&lt;0.001),C-reactive protein(CRP)level(&lt;i&gt;r&lt;/i&gt;=0.440,&lt;i&gt;P&lt;/i&gt;&lt;0.001),HADS score of anxiety(&lt;i&gt;r&lt;/i&gt;=0.420,&lt;i&gt;P&lt;/i&gt;=0.005),interleukin-6 level(&lt;i&gt;r&lt;/i&gt;=0.397,&lt;i&gt;P&lt;/i&gt;=0.004),the overall assessment of disease activity(&lt;i&gt;r&lt;/i&gt;=0.318,&lt;i&gt;P&lt;/i&gt;=0.036),and the course of psoriatic arthritis(&lt;i&gt;r&lt;/i&gt;=0.330,&lt;i&gt;P&lt;/i&gt;=0.028).The serum HDAC8 level was positively correlated with HADS score of anxiety(&lt;i&gt;r&lt;/i&gt;=0.477,&lt;i&gt;P&lt;/i&gt;=0.008)and erythrocyte sedimentation rate(&lt;i&gt;r&lt;/i&gt;=0.385,&lt;i&gt;P&lt;/i&gt;=0.039).Compared with the patients with low disease activity,those with moderate to high disease activity presented up-regulated expression of HDAC3(&lt;i&gt;P&lt;/i&gt;=0.041).HDAC2(&lt;i&gt;P&lt;/i&gt;=0.028)and CRP(&lt;i&gt;P&lt;/i&gt;=0.034)were risk factors for moderate to high disease activity in PsA patients.HDAC2(area under the curve=0.802,&lt;i&gt;P&lt;/i&gt;=0.003)and CRP(area under the curve=0.718,&lt;i&gt;P&lt;/i&gt;=0.033)had diagnostic value for the progression of PsA.Conclusions The expression levels of class Ⅰ HDAC in the serum of patients with newly diagnosed PsA were significantly different.The serum levels of HDAC2 and CRP are exp","PeriodicalId":6919,"journal":{"name":"中国医学科学院学报","volume":"47 4","pages":"557-566"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145063172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research Progress in Application of Sensory Stimulation Therapy in Patients With Alzheimer's Disease.","authors":"Pan Liu, Yue Zhang, Qing-Hui Meng","doi":"10.3881/j.issn.1000-503X.16375","DOIUrl":"10.3881/j.issn.1000-503X.16375","url":null,"abstract":"<p><p>As population aging aggravates,the prevalence of dementia is increasing,seriously impacting the daily lives of patients.Sensory stimulation therapy has emerged as a safe and effective non-pharmacological intervention for individuals with dementia.Consequently,exploring non-pharmacological treatments for Alzheimer's disease is crucial.By a review of the relevant literature,this paper provides an overview of sensory stimulation therapy in terms of the concept,applications,and effects on dementia,aiming to promote the broader implementation of this therapy in the care of individuals with dementia.</p>","PeriodicalId":6919,"journal":{"name":"中国医学科学院学报","volume":"47 4","pages":"621-627"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145063104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functional Mechanisms of Spinal Cord Fragile X Mental Retardation Protein and β-Catenin Involved in Neuropathic Pain.","authors":"Long Zhang, Jin-Song Zhao, Li Zhou, Lei Chen, Zhi-Ying Feng","doi":"10.3881/j.issn.1000-503X.16494","DOIUrl":"10.3881/j.issn.1000-503X.16494","url":null,"abstract":"<p><p>Objective To explore the functional mechanism of spinal cord fragile X mental retardation protein(FMRP)involved in neuropathic pain(NP)by using the sciatic nerve model of chronic compression injury(CCI).Methods First,to investigate the changes of spinal cord FMRP and β-catenin following the development of NP,this study compared the 50%mechanical withdrawal threshold(MWT)and thermal withdrawal latency(TWL)in CCI rats,as well as changes of FMRP and β-catenin in the spinal dorsal horn post-surgery,through random grouping.Immunofluorescence staining was performed on spinal cord tissue sections from CCI rats.Second,to further validate the alterations in pain behavior when the FMRP function was lost,we measured the 50%MWT,TWL,and FMRP and β-catenin in the spinal dorsal horn after FMRP knockdown in CCI rats.Finally,we measured the 50%MWT,TWL,and FMRP and β-catenin in the case of FMRP hyperfunction for validation.Results Compared with the baseline CCI group and the naive and sham groups after modeling,the CCI group after modeling showed decreases in 50%MWT and TWL(all <i>P</i><0.001).After modeling,compared with the naive group and the sham group,the CCI group presented up-regulated expression of FMRP(<i>P</i>=0.027,<i>P</i>=0.022)and β-catenin(<i>P</i><0.001,<i>P</i>=0.001)in the spinal dorsal horn.No co-localization of FMRP with astrocytes and microglia was observed in the spinal cord,while the co-localization with neurons was observed.Compared with the baseline,the CCI+FMRP knockdown group showed decreases in 50%MWT(<i>P</i>=0.015)and TWL(<i>P</i>=0.001)after modeling.After intrathecal injection of small interfering RNA(siRNA),the 50%MWT(<i>P</i>=0.020)and TWL(<i>P</i>=0.009)of the CCI+FMRP knockdown group were increased.Moreover,compared with the CCI group and the CCI+solvent group,the CCI+FMRP knockdown group showed increases in 50%MWT(both <i>P</i><0.001)and TWL(<i>P</i>=0.005,<i>P</i>=0.006).After intrathecal injection of siRNA,the expression levels of FMRP(<i>P</i>=0.012,<i>P</i>=0.007)and β-catenin(both <i>P</i><0.001)in the spinal dorsal horn of the CCI+FMRP knockdown group were lower than those of the CCI group and the CCI+solvent group.Compared with the baseline FMRP overexpression group and the naive and negative control groups after adeno-associated virus(AAV)injection,the FMRP overexpression group after AAV injection showed decreases in 50%MWT and TWL(all <i>P</i><0.001).After AAV injection,compared with the naive group and the negative control group,the FMRP overexpression group demonstrated up-regulated expression of FMRP(both <i>P</i><0.001)and β-catenin(<i>P</i>=0.006,<i>P</i>=0.008)in the spinal cord.Conclusions This study confirms that spinal cord FMRP and β-catenin are involved in NP induced by CCI.Spinal cord FMRP may be one of the potential therapeutic targets for NP.</p>","PeriodicalId":6919,"journal":{"name":"中国医学科学院学报","volume":"47 4","pages":"509-518"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145063267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Listeria Brainstem Encephalitis With Myelitis Misdiagnosed as Acute Disseminated Encephalomyelitis:Report of One Case.","authors":"Dan-Ying Wu, Qin-Xue Wang, Dong-Mei Zhu, Yu-Jing Gan, Min Huang, Su-Ming Zhou","doi":"10.3881/j.issn.1000-503X.16340","DOIUrl":"10.3881/j.issn.1000-503X.16340","url":null,"abstract":"<p><p>Listeria brainstem encephalitis with myelitis is extremely rare in clinical practice.Since the clinical manifestations are non-specific,MRI is helpful for diagnosis.Positive cerebrospinal fluid culture is considered the gold standard for diagnosis.This article reports a case of an immunocompetent individual with listeria brainstem encephalitis with myelitis,aiming to enhance the awareness of this condition.</p>","PeriodicalId":6919,"journal":{"name":"中国医学科学院学报","volume":"47 4","pages":"673-678"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145063221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coronary Computed Tomographic Angiography-Derived Radiomics Combing CT-Fractional Flow Reserve for Detecting Hemodynamically Significant Coronary Artery Disease.","authors":"Yan Yi, Cheng Xu, Wei Wu, Ying-Qian Ge, Ke-Ting Xu, Xian-Bo Yu, Yi-Ning Wang","doi":"10.3881/j.issn.1000-503X.16412","DOIUrl":"10.3881/j.issn.1000-503X.16412","url":null,"abstract":"<p><p>Objective To develop a diagnostic model combining the CT angiography(CCTA)-derived myocardial radiomics signatures with the CT-derived fractional flow reserve(CT-FFR)based on coronary CCTA and investigate the diagnostic accuracy of the hybrid model for hemodynamically significant coronary artery disease(CAD).Methods The patients presenting stable angina pectoris,diagnosed with CAD,and clinically referred for CCTA examination and invasive coronary angiography were prospectively recruited.Radiomics features of the left ventricular myocardium were extracted from the three main perfusion territories demarcated according to the coronary blood supply.The extracted features were first selected by the minimum redundancy maximum relevance feature ranking method.A least absolute shrinkage and selection operator Logistic regression algorithm with leave-one-out cross-validation was then employed to construct a radiomics model.The CT-FFR value was generated for each blood vessel.The area under the receiver operating characteristics curve(AUC_ROC),sensitivity,and specificity were adopted to evaluate the performance of each model against the reference standard invasive coronary angiography/FFR.Results A total of 70 patients[42 men and 28 women;(61±10) years old] were included in this study and complemented CCTA examination,with 175 vessels and the corresponding myocardial territories undergoing invasive coronary angiography/FFR.A total of 1 656 specific radiomics parameters were extracted,from which 14 features were selected to establish the radiomics model.The AUC_ROC,sensitivity,and specificity were 0.797(95%<i>CI</i>=0.732-0.861),77.1%,and 73.7%for the radiomics model,0.892(95%<i>CI</i>=0.841-0.943),81.4%,and 88.8%for the CT-FFR model,and 0.928(95%<i>CI</i>=0.890-0.965),83.3%,and 88.4%for the hybrid model,respectively.The hybrid model outperformed the radiomics model and CT-FFR alone(<i>P</i>=0.040).Conclusions The radiomics signatures of the vessel-related myocardium from CCTA could provide incremental value to the diagnostic performance of CT-FFR and improve vessel-specific ischemia detection.The hybrid model combining CT-FFR with radiomics signatures is potentially feasible for improving the diagnostic accuracy for hemodynamically significant CAD.</p>","PeriodicalId":6919,"journal":{"name":"中国医学科学院学报","volume":"47 4","pages":"542-549"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145063205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bibliometric Analysis of Intelligent Ultrasound Imaging in the Diagnosis of Thyroid Nodules.","authors":"Yang Li, Jian-Lin Wang, Jiao-Jiao Ma, Zhe Sun, Bo Zhang","doi":"10.3881/j.issn.1000-503X.16324","DOIUrl":"10.3881/j.issn.1000-503X.16324","url":null,"abstract":"<p><p>Objective To explore the research progress and hotspots of intelligent ultrasound imaging in the diagnosis of thyroid nodules and clarify the research directions via the bibliometric method.Methods The relevant research articles on intelligent ultrasound imaging in the diagnosis of thyroid nodules were retrieved from the Web of Science Core Collection,covering the period from January 2004 to August 2024.Python was used to analyze the number of annual publications.VOSviewer was used to create the co-occurrence network of authors and the keyword density map.CiteSpace was used to demonstrate the dual-map overlays of the journals,as well as the bursts and clustering of co-citations and keywords.Results A total of 1 179 articles were included.The annual number of publications increased steadily.The involved journals demonstrated high quality,and the publications showed a trend of cross-research.Chinese researchers were the core research force in this field.Haugen et al.'s study on the guidelines for thyroid nodules had the most citations.The clustering of co-citations and keywords indicated studies in multiple fields.Thyroid nodules,cancer,and deep learning were the representative keywords in this field.Conclusions The continuous enrichment of research topics promotes the rapid development of intelligent ultrasound imaging for thyroid nodules.Intelligent diagnosis methods based on deep learning can provide diagnostic suggestions,while there are still challenges such as interpretation.One of the research directions is the deep combination of intelligent diagnosis algorithms and medical knowledge.</p>","PeriodicalId":6919,"journal":{"name":"中国医学科学院学报","volume":"47 4","pages":"590-600"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145063248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}