中国医学科学院学报最新文献

{"title":"Value of Amide Proton Transfer-Weighted Imaging and T2 Mapping for Predicting Microsatellite Instability in Endometrial Adenocarcinoma.","authors":"Lian-Hua Cheng, Ling-Yu Chang, De-Xin Yu, Qing Wang, Jin-Zheng Jia, Fang Wang","doi":"10.3881/j.issn.1000-503X.16469","DOIUrl":"https://doi.org/10.3881/j.issn.1000-503X.16469","url":null,"abstract":"<p><p>Objective To identify the feasibility of amide proton transfer-weighted imaging(APTw)and T2 mapping parameters in assessing microsatellite instability(MSI)in endometrial adenocarcinoma(EA). Methods Patients with clinically suspected endometrial cancer were prospectively enrolled and underwent MRI before the operation,which mainly included APTw and T2 mapping.Two radiologists independently performed regions of interest and measured the quantitative parameters.The intraclass correlation coefficients were used to assess the interobserver agreement,the independent samples t-test and Mann-Whitney U test were applied to compare quantitative variables between the MSI and microsatellite stable(MSS)groups,the receiver operator characteristic(ROC)curve was conducted to evaluate the predictive performances of different parameters,the Delong test was implemented to compare the area under the curve(AUC)between single parameters and their combination. Results Twenty-one patients in the MSI group and 37 patients in the MSS group were finally enrolled in this study.The results showed excellent observer agreements between two observers in assessing MRI parameters.APTw values[(2.72±0.52)% vs.(2.08±0.39)%,P<0.001]in the MSI group were significantly higher than those in the MSS group, T2 values [92.25(90.82, 99.91) ms vs.101.80(96.15, 112.13)ms, P<0.001]were significantly lower in the MSI group than those in the MSS group.The ROC curves showed that the AUCs of APTw and T2 values were 0.821 and 0.793,respectively,and no significant difference was observed between the two sequences(P＞0.05).The combination of APTw and T2 mapping yielded the highest AUC of 0.897,which was significantly higher than APTw and T2 mapping alone(both P＜0.05). Conclusion APTw and T2 mapping were valuable in assessing the MSI of EA,and the combination of the two parameters showed a higher diagnostic efficacy,thus providing an efficient basis for the selection of preoperative therapeutic modalities for the patients.</p>","PeriodicalId":6919,"journal":{"name":"中国医学科学院学报","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144635891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of the Burden and Changing Trends of Nonalcoholic Fatty Liver Disease in China from 1990 to 2021.","authors":"Jun Tang, Nan Zheng, Yu-Xin Yan, Nan Zhang, Xiao-Mei Ren","doi":"10.3881/j.issn.1000-503X.16339","DOIUrl":"https://doi.org/10.3881/j.issn.1000-503X.16339","url":null,"abstract":"<p><p>Objective To analyze the trend of disease burden changes in non-alcoholic fatty liver disease(NAFLD)in China from 1990 to 2021,and provide a basis for formulating prevention and treatment strategies.Methods The standardized incidence rate,prevalence,mortality and disability adjusted life year(DALY)rate of NAFLD in China from 1990 to 2021 in the Global Burden of Disease Study 2021 were extracted.The average annual percentage change of the rate was calculated by Joinpoint 4.2 and the age,period and birth cohort effects of the prevalence and DALY rate were analyzed by age-period-cohort model.Results Since 1990,the incidence rate and prevalence of NAFLD have been on the rise,while the mortality and DALY have been on the decline.The age effect of disease incidence and DALY rate shows an upward trend followed by a downward trend for both males and females.The period effect is based on the period from 1992 to 1996 as the reference group,and the overall trend of the disease incidence period effect curve shows a downward trend followed by an upward trend,with the period from 2002 to 2006 being the lowest point(RR=0.93).The period effect curves of DALY showed a downward trend from 1992 to 2011,and then tended to flatten out.The birth cohort effect was used as the reference group from 1972 to 1981,and the incidence rate showed a steady upward trend in the general population,male and female populations.The DALY rate showed an overall upward trend followed by a downward trend,with the peak occurring in the birth cohort group between 1922 and 1931.The DALY rate of NAFLD caused by smoking and high fasting blood glucose has shown a downward trend since 2014,and fasting blood glucose gradually becomes the dominant factor with age.Conclusions The prevalence of NAFLD in China has been on the rise from 1990 to 2021,but the DALY rate has significantly decreased.This suggests that current prevention and control strategies are effective,and further efforts should be made to raise residents' health awareness and control the occurrence and development of NAFLD.</p>","PeriodicalId":6919,"journal":{"name":"中国医学科学院学报","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144582792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of 24 h Ambulatory Blood Pressure Control Among Hypertensive Patients in Communities in Different Time Periods and Analysis of Its Influencing Factors.","authors":"Xiang Huang, Hua-Jie Yang, Yong-Jun Zheng, Yu-Ting Li, Jie-Zhen Feng, Hao-Xiang Wang, Ling Wang","doi":"10.3881/j.issn.1000-503X.16379","DOIUrl":"https://doi.org/10.3881/j.issn.1000-503X.16379","url":null,"abstract":"<p><p>Objective To assess the blood pressure control and its influencing factors among hypertensive patients in communities in different time periods by 24 h ambulatory blood pressure monitoring(24 h ABPM)and provide reference for optimizing the health management services for hypertension in communities. Methods A total of 765 hypertensive patients registered in the hypertension management project of national essential public health services in Sanxiang Town,Zhongshan City from October 2022 to September 2023 were identified as target subjects.The 24 h ABPM devices were distributed for blood pressure monitoring and a questionnaire survey was conducted to analyze the influencing factors of blood pressure control. Results Of all the participants,16.5% did not monitor blood pressure regularly,and 59.2% monitored blood pressure 1-2 times per week.The patients who were not on night shifts/staying up late had higher mean rates of achieving the target blood pressure and the circadian rhythm of blood pressure during 24 h,nighttime,and early morning than those who were on night shifts/staying up late(P<0.05 for all).The patients who never drank alcohol had higher rate of achieving the target blood pressure in early morning than those who drank alcohol(P<0.05).The average blood pressure during daytime,nighttime,and 24 h were different by sex(P<0.05 for all).The average blood pressure during nighttime was different by age and job types(P<0.05 for all).The average blood pressure during daytime,nighttime,and 24 h were different in patients with different body weight types(P<0.05 for all).The results of the multivariate logistic regression analysis showed that uncontrolled blood pressure during daytime was more likely to occur in male patients(OR=1.394,95%CI:1.045-1.858,P=0.024),and that during nighttime was more likely to be associated with male patients(OR=1.573,95%CI:1.088-2.275,P=0.016)and night shifts(OR=2.467,95%CI:1.198-5.077,P=0.014).It was difficult to achieve blood pressure control in early morning for the patients who drank alcohol for more than three times per week(OR=4.567,95%CI:1.629-12.807,P=0.004),woke up at night(OR=1.800,95%CI:1.125-2.878,P=0.014),and had night shifts(OR=1.579,95%CI:1.102-2.465,P=0.044).The patients on night shifts were more likely to have abnormal circadian rhythm of blood pressure(OR=1.753,95%CI:1.018-3.018,P=0.043). Conclusion The personal characteristics and lifestyle of hypertensive patients significantly affect the blood pressure control in different time periods(daytime,nighttime,and early morning)and the circadian rhythm of blood pressure.The family doctor team of community healthcare institutions can implement targeted and precise intervention measures for hypertensive patients according to the influencing factors of blood pressure control in different time periods,so as to achieve better management effects.</p>","PeriodicalId":6919,"journal":{"name":"中国医学科学院学报","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144504365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiology of Social Isolation Among Middle-aged and Older Adults in China.","authors":"Lin Zhang, Shu Jing, Xue-Lin Yang, Yu-Ping Wang, Xiao-You Su","doi":"10.3881/j.issn.1000-503X.16657","DOIUrl":"https://doi.org/10.3881/j.issn.1000-503X.16657","url":null,"abstract":"<p><p>Objective To explore the contemporary prevalence,cumulative incidence,distribution characteristics,and correlates of social isolation among middle-aged and older adults aged 45 years and older in China. Methods This study utilized data from the China Health and Retirement Longitudinal Study.Cross-sectional studies with stratified analysis were conducted to investigate the prevalence of social isolation and its age,gender,and regional differences in 2018 and 2020.A cohort study and binary logistic regression models were employed to analyze the cumulative incidence of social isolation and its correlates from 2018 to 2020.Multiple imputation based on chained equations and sensitivity analyses based on complete-case data were employed to ensure the reliability of the analysis. Results In 2018,the weighted prevalence of social isolation among middle-aged and older adults was 16.48%(95%CI=15.67%-17.32%).In 2020,the weighted prevalence of social isolation among middle-aged and older adults was 18.84%(95%CI=17.93%-19.74%).Weighted stratified analyses indicated that the prevalence of social isolation was significantly higher among older adults,individuals residing in rural areas,and females.The weighted cumulative incidence of social isolation during 2018-2020 was 9.24%(95%CI=8.47%-10.02%).The analysis revealed that 34.02%(95%CI=32.85%-35.19%)of middle-aged and older adults exhibited depressive symptoms.Depressive symptoms(OR=1.38,95%CI=1.07-1.78,P=0.013)were significantly associated with an elevated risk of social isolation. Conclusion The study reveals the epidemiology of social isolation among middle-aged and older adults in China,identifying advanced age,female gender,rural residence,and depressive symptoms as key correlates.These findings emphasize the need for early health management strategies to address social isolation in these high-risk populations.</p>","PeriodicalId":6919,"journal":{"name":"中国医学科学院学报","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144109166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Study on HPV Testing and Infection StatusAmong Men Who Have Sex with Men Using Geosocial Networking Apps.","authors":"Xin Liu, Jing-Jie Fan, Zhen-Wei Dai, Mo-Han Lyu, Fei Yu, Xiao-You Su, Sheng-Lan Tang, You-Lin Qiao","doi":"10.3881/j.issn.1000-503X.16539","DOIUrl":"https://doi.org/10.3881/j.issn.1000-503X.16539","url":null,"abstract":"<p><p>Objective This study aims to assess the coverage of human papillomavirus(HPV)testing and the prevalence of HPV infection among men who have sex with men(MSM)using geosocial networking apps in China.It also explores the related influencing factors to provide evidence for designing effective prevention and control strategies for this population. Methods The study was conducted from July to August 2024 and recruited participants via the Blued app.Univariate and multivariate logistic regression models were used to analyze factors associated with HPV testing and infection among MSM. Results Among the 1,080 participants,23.3% had undergone HPV testing,and 43.3% of those tested were positive for HPV. The main reason for HPV testing was the presence or suspicion of HPV-related symptoms(<i>n</i>=224,58.9%).Logistic regression analysis showed that MSM with higher levels of HPV knowledge,higher income,and those who self-identified as homosexuals were more likely to undergo HPV testing.Additionally,MSM with higher HPV knowledge,those who self-identified as homosexuals,those who had sex with women in the past six months,and HIV-positive MSM were identified as high-risk groups for HPV infection. Conclusions In China,the HPV testing rate among MSM using geosocial networking apps is low.However,the prevalence of HPV infection remains relatively high.Therefore,the government and community should enhance HPV knowledge dissemination,promote HPV testing,and improve the accessibility and quality of HPV testing services.By doing so,they can increase the testing coverage and effectively control the spread of HPV among MSM.</p>","PeriodicalId":6919,"journal":{"name":"中国医学科学院学报","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143960657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accumulated Effects of 24 Hours Physical Activity,Sedentary Behavior,and Sleep on Cardiorespiratory Fitness in College Students.","authors":"Yun-Feng Song, Chi Xu, Kai-Xin Li, Si-Jie Tan, Yu-Gang Qi","doi":"10.3881/j.issn.1000-503X.16102","DOIUrl":"https://doi.org/10.3881/j.issn.1000-503X.16102","url":null,"abstract":"<p><p>Objective To explore the accumulated effects of physical activity,sedentary behavior,and sleep on cardiorespiratory fitness(CRF)among college students and provide effective measures for enhancing their CRF. Methods From May to June in 2023,223 college students aged 18 to 24 years old were recruited from Tianjin University of Science and Technology for a 24 hours activity behavior survey and CRF testing.Compositional analysis was employed to investigate the relationships of physical activity,sedentary behavior,and sleep with CRF.Isotemporal substitution models were established to predict the effects of substituting various activity behaviors on CRF.Results The proportion of time spent on moderate-to-vigorous physical activity(MVPA)was positively correlated with CRF of college students(<i>β</i>=6.40,<i>P</i>=0.002),while the proportion of time spent on sedentary behavior was negatively correlated with CRF(<i>β</i>=-3.02,<i>P</i>=0.004).Light physical activity(LPA)and sleep were not correlated with CRF(<i>β</i>=-1.06,<i>P</i>=0.504).Isotemporal substitution results for 15-min increments showed that replacing other activity behaviors with MVPA significantly increased the CRF of college students[SB:1.72 mL/(kg·min),95% <i>CI</i>=0.94-2.51;LPA:1.82 mL/(kg·min),95% <i>CI</i>=0.95-2.68;sleep:1.64 mL/(kg·min),95% <i>CI</i>=0.84-2.45].In the dose-response relationship from -30 min to 30 min,reallocating time from other behaviors to MVPA had greater adverse effect on CRF than reallocating time from MVPA to other behaviors.Among all the substitutions,replacing LPA with MVPA had the most beneficial effect on improving CRF.Additionally,a 5-min increment was considered the optimal tipping point for MVPA replacing other activities.Conclusions This study underscores the importance of participating in MVPA for improving the CRF of college students.The isotemporal substitution model provides clear goals for the allocation of time for these behaviors,aiding in future intervention measure development and policy-making.</p>","PeriodicalId":6919,"journal":{"name":"中国医学科学院学报","volume":"47 2","pages":"155-163"},"PeriodicalIF":0.0,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143960028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Conception of the Discipline Construction of Palliative Medicine.","authors":"Fei Li, Jia-Xin Zhou, Xiao-Hong Ning","doi":"10.3881/j.issn.1000-503X.16652","DOIUrl":"https://doi.org/10.3881/j.issn.1000-503X.16652","url":null,"abstract":"<p><p>As palliative care practice gradually undertakes important missions in both the medical field and the society,it has become an emerging disciplinary area that meets the needs of the times.At the same time,the discipline construction of palliative medicine has become a crucial issue that urgently needs to be addressed in the cause of palliative care in China.In this article,we trace the origin of the concept of palliative care and classify,sort out,and expound the research objects,research contents,research methods,etc.of palliative medicine by combining the methods of literature analysis and focus group interviews.According to the development context and evolution process of palliative care,we put forward the proposition of building a discipline of palliative medicine,with the aim of helping the academic community distinguish the connotation and denotation of the disciplinary definition and laying a foundation for the work of discipline construction.</p>","PeriodicalId":6919,"journal":{"name":"中国医学科学院学报","volume":"47 2","pages":"259-264"},"PeriodicalIF":0.0,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143956938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research Progress in the Role of Testosterone in Male Depression.","authors":"Jia-Min Fu, Qi Guo, Xiao-Yu Chen","doi":"10.3881/j.issn.1000-503X.16142","DOIUrl":"https://doi.org/10.3881/j.issn.1000-503X.16142","url":null,"abstract":"<p><p>As the social pressure is increasing,the incidence of depression is growing.Testosterone is synthesized and secreted through the hypothalamic-pituitary-gonadal axis,which plays a regulatory role in men's mental health.Studies have shown that low testosterone levels,clinical hypogonadism,and androgen deprivation therapy-induced testosterone deficiency are significantly associated with male depression,while there are still many uncertainties about the mechanism of their effects.Given that low testosterone levels may serve as a characteristic biomarker of male depression risk,testosterone replacement therapy may have a good therapeutic effect on male depression.This article focuses on assessing the role of testosterone levels and related clinical therapies in mood regulation in men.</p>","PeriodicalId":6919,"journal":{"name":"中国医学科学院学报","volume":"47 2","pages":"274-280"},"PeriodicalIF":0.0,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143962221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Altered Cerebral Blood Flow in Type 2 Diabetes Mellitus Without Cognitive Impairment.","authors":"Jia-Ying Yang, Xue-Wei Zhang, Xue-Qing Liu, Jia-Min Zhou, Miao He, Jing Li, Xia-Li Shao, Wen-Hui Li, Yu-Zhou Guan, Wei-Hong Zhang, Feng Feng","doi":"10.3881/j.issn.1000-503X.16155","DOIUrl":"https://doi.org/10.3881/j.issn.1000-503X.16155","url":null,"abstract":"<p><p>Objective To investigate the alterations of cerebral blood flow(CBF)in type 2 diabetic mellitus(T2DM) patients without cognitive impairment by using arterial spin labeling(ASL)technique.Methods A total of 23 T2DM patients without cognitive impairment and 23 healthy controls(HC)matched by age,sex,and education attainment were recruited.Their clinical data were collected,and neuropsychological tests and cerebral magnetic resonance imaging were performed.Then,the outcomes of clinical features,neuropsychological tests,and global and regional CBF were compared between the two groups.The significant regional zCBF(z-transformed relative CBF)values were extracted and correlated with clinical data and neuropsychological scores in T2DM patients,controlling age,sex,and education.Results No significant difference was found in whole brain CBF between the two groups(<i>P</i>=0.155),while significantly higher CBF was identified in the left superior temporal gyrus and left insula in the T2DM group(Gaussian random field correction,initial threshold <i>P</i> < 0.001,cluster level <i>P</i> < 0.05).No correlation was observed between the significant regional zCBF values and the clinical data or the neuropsychological scores in T2DM patients(all <i>P</i>>0.05).Conclusion Alterations in cerebral hemodynamics may precede cognitive function changes in T2DM,suggesting that the ASL technique is promising for early monitoring of cerebral hemodynamic changes associated with cognitive impairment in patients with T2DM.</p>","PeriodicalId":6919,"journal":{"name":"中国医学科学院学报","volume":"47 2","pages":"219-225"},"PeriodicalIF":0.0,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143959001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Compositional Isotemporal Substitutions of 24 Hours Activity Behaviors on Novel Obesity Indicators in College Students.","authors":"Yun-Feng Song, Chi Xu, Si-Jie Tan, Yu-Gang Qi","doi":"10.3881/j.issn.1000-503X.16362","DOIUrl":"https://doi.org/10.3881/j.issn.1000-503X.16362","url":null,"abstract":"<p><p>Objective To explore the effects of time reallocation among moderate-to-vigorous physical activity(MVPA),light physical activity(LPA),sedentary behavior(SB),and sleep on a body shape index(ABSI),body roundness index(BRI),conicity index(CI),and relative fat mass(RFM)of college students by the compositional isotemporal substitution method,thus providing measures for alleviating the obesity problem of college students. Methods Two hundred and ten college students(111 males and 99 females)aged 18-22 years old were recruited from Tianjin University of Science and Technology from April to June in 2023.Three-dimensional acceleration sensors were used to collect data of MVPA,LPA,SB,and sleep of college students.The body height,body weight,and waist circumference were measured,and four novel obesity indicators(ABSI,BRI,CI,and RFM)were calculated.The effects of substituting each activity behavior for 15 min on the obesity indicators were predicted,and the dose-effect relationship was explored at intervals of 5 min from -30 to 30 min.Results MVPA was negatively correlated with ABSI(<i>β</i>=-0.03,<i>P</i>=0.001),BRI(<i>β</i>=-0.27,<i>P</i>=0.049),CI(<i>β</i>=-0.10,<i>P</i>=0.001),and RFM(<i>β</i>=-9.95,<i>P</i>=0.004).LPA was negatively correlated with CI(<i>β</i>=-0.05,<i>P</i>=0.011)and RFM(<i>β</i>=-8.74,<i>P</i>=0.007).Neither SB nor sleep had correlations with ABSI,BRI,CI,and RFM.The results of 15 min isotemporal substitutions showed that increasing the MVPA time decreased the ABSI,BRI,CI,and RFM by 0.006-0.008,0.306-0.393,0.162-0.205,and 2.468-2.897,respectively.Decreasing the MVPA time increased the ABSI,BRI,CI,and RFM by 0.012-0.014,0.548-0.632,0.286-0.328,and 4.358-4.748,respectively.In the dose-effect relationship from -30 min to 30 min,MVPA was irreplaceable,and the negative benefits from substituting MVPA for other activity behaviors were much greater than the positive benefits from substituting MVPA for other activity behaviors.Conclusions Future research should take 24 hours activity behaviors as a whole.Increasing the time spent on MVPA and LPA and decreasing the time spent on SB is one of the effective ways to alleviate the obesity problem among college students.</p>","PeriodicalId":6919,"journal":{"name":"中国医学科学院学报","volume":"47 2","pages":"164-174"},"PeriodicalIF":0.0,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143959037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}