中国医学科学院学报最新文献

{"title":"Efficacy and Safety of Systemic Thrombolysis in the Treatment of Lower Extremity Fracture Complicated With Distal Deep Vein Thrombosis.","authors":"Shi-Qiang Liao, Shu-Ming Shi, Qiang Zhang, Chuan-Yong Li, Guang-Feng Zheng, Zhi-Chang Pan, Jian-Jie Rong","doi":"10.3881/j.issn.1000-503X.16171","DOIUrl":"https://doi.org/10.3881/j.issn.1000-503X.16171","url":null,"abstract":"<p><p>Objective To evaluate the efficacy and safety of systemic thrombolysis(ST)and standard anticoagulation(SA)in the treatment of lower extremity fracture complicated with distal deep vein thrombosis(DDVT).Methods We retrospectively analyzed the clinical data of 60 patients with lower extremity fracture complicated with DDVT treated from January 2021 to December 2023.When the lower limb venography indicated a calf thrombus burden score ≥3 points,a retrievable inferior vena cava filter(IVCF)was successfully placed in the healthy femoral vein before orthopedic surgery.The patients who received further anticoagulant or thrombolytic therapy after surgery were allocated into a ST group(<i>n</i>=30,urokinase ST and SA)and a SA group(<i>n</i>=30,only SA).The two groups were compared in terms of calf thrombus burden score,thrombus dissolution rate,IVCF placement time,IVCF retrieval rate,intercepted thrombi,hemoglobin level,platelet count,D-dimer level,and complications.Results There was no statistically significant difference in the calf thrombus burden score between the two groups before treatment(<i>P</i>=0.431).However,after treatment,the scores in both groups decreased(both <i>P</i><0.001),with the ST group showing lower score than the SA group(<i>P</i>=0.002).The thrombus dissolution rate in the ST group was higher than that in the SA group(<i>P</i><0.001).There was no statistically significant difference in the IVCF placement time between the two groups(<i>P</i>=0.359),and the IVCF retrieval rate was 100% in both groups.The ST group had fewer intercepted thrombi than the SA group(<i>P</i>=0.002).There was no statistically significant difference in hemoglobin level(<i>P</i>=0.238),platelet count(<i>P</i>=0.914),or D-dimer level(<i>P</i>=0.756)between the two groups before treatment.However,after treatment,both groups showed an increase in platelet count(both <i>P</i><0.001)and a decrease in D-dimer level(both <i>P</i><0.001).There was no statistically significant difference in the occurrence of complications between the two groups(<i>P</i>=0.704).Conclusions Both SA and ST demonstrate safety and efficacy in the treatment of lower extremity fractures complicated with DDVT,serving as valuable options for clinical application.Compared with SA,ST not only enhances the thrombus dissolution in the calf but also mitigates the risk of thrombosis associated with IVCF.</p>","PeriodicalId":6919,"journal":{"name":"中国医学科学院学报","volume":"47 2","pages":"237-243"},"PeriodicalIF":0.0,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143955343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cross-Sectional Analysis of the Relationship Between Bedtime Procrastination and Fear of Missing Out and the Effect of Exercise Intervention.","authors":"Jun-Ge Peng, Meng-Ying Zhang, Jiang Xiao, Kai-Xin Li, Yue Zhao, Yan Li","doi":"10.3881/j.issn.1000-503X.16275","DOIUrl":"https://doi.org/10.3881/j.issn.1000-503X.16275","url":null,"abstract":"<p><p>Objective To explore the relationship between bedtime procrastination and fear of missing out and the intervention effect of aerobic exercise on bedtime procrastination,so as to provide a theoretical basis and practical reference for remedying bedtime procrastination.Methods Totally 988 students were selected through random sampling and then surveyed with the bedtime procrastination scale and the fear of missing out scale.Correlation and regression analyses were performed to explore the relationship between bedtime procrastination and fear of missing out.A total of 36 students were recruited from the 988 students to participate in the exercise intervention and they were assigned into an exercise group and a control group by the random number table method,with 18 students in each group.The exercise group performed aerobic exercise for 12 weeks,while the control group maintained daily activities.The participants' scores on the bedtime procrastination scale and the fear of missing out scale were recorded before and after the intervention and compared.Results The fear of missing out was positively correlated with bedtime procrastination among college students(<i>r</i>=0.214,<i>P</i><0.001),and it was an important predictive factor for bedtime procrastination(<i>β</i>=0.241,<i>P</i><0.001).After the intervention,the scores of bedtime procrastination scale decreased in the exercise group(<i>t</i>=2.277,<i>P</i>=0.036),while there was no significant difference in the scores of the control group before and after intervention(<i>t</i>=-0.787,<i>P</i>=0.442).Conclusions A high level of fear of missing out indicates severe bedtime procrastination.And 12-week exercise intervention could remedy bedtime procrastination.</p>","PeriodicalId":6919,"journal":{"name":"中国医学科学院学报","volume":"47 2","pages":"175-181"},"PeriodicalIF":0.0,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143962655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Primary Non-Hodgkin Lymphoma in the Female Genital System: Report of Two Cases and Review of the Literature.","authors":"Tian-Yu Zhang, Li Qin, Dong-Yan Cao, Jia-Xin Yang, Yi Liu, Tao Wang","doi":"10.3881/j.issn.1000-503X.16116","DOIUrl":"https://doi.org/10.3881/j.issn.1000-503X.16116","url":null,"abstract":"<p><p>Primary female genital system lymphoma(PFGSL)is a rare subtype of extranodal lymphoma and patients commonly present in the department of gynecology.At present,there is a lack of uniform standards for the treatment of PFGSL.Although the classification of lymphoid neoplasmas was updated by the World Health Organization classification of haematolymphoid tumors in 2016,PFGSL was still not elaborated in sufficient detail.Most cases of PFGSL are non-Hodgkin lymphoma,involving the ovary and cervix.In some cases,involvement of uterine corpus,vagina,and vulva is reported.In this article,we report two cases of non-Hodgkin lymphoma in the female genital system,one from the uterus and the other from the ovary.By presenting the diagnosis and treatment of the two cases and reviewing the literature,we aim to provide a reference for clinicians in recognizing and treating rare cases.</p>","PeriodicalId":6919,"journal":{"name":"中国医学科学院学报","volume":"47 2","pages":"314-318"},"PeriodicalIF":0.0,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143955354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Triglyceride-Glucose Index on the Risk of Inflammatory Bowel Disease.","authors":"Wang-Dong Fan, Wen-Qian Yu","doi":"10.3881/j.issn.1000-503X.16205","DOIUrl":"https://doi.org/10.3881/j.issn.1000-503X.16205","url":null,"abstract":"<p><p>Objective To investigate the impact of the triglyceride-glucose(TyG)index on the risk of inflammatory bowel disease(IBD).Methods Based on the data from UK Biobank,participants were allocated into three groups,TyG1(≤4.564),TyG2(4.564-4.808),and TyG3(≥4.808),according to tertiles of the TyG index.Kaplan-Meier curves were established to analyze the cumulative incidence of IBD.Further,Cox proportional hazard regression was employed to analyze the hazard ratio(<i>HR</i>)and its 95% confidential interval(95%<i>CI</i>)of each group.The same analysis was conducted for different subtypes(ulcerative colitis and Crohn's disease)of IBD.Sensitive analysis based on the competing risk model was performed after excluding participants who were diagnosed within one year.Results A total of 116 423 participants were included in this study,with the median follow-up time of 12.56 years.The incidence densities of IBD in the TyG1,TyG2,and TyG3 groups were 4.47,5.94,and 6.50 per 10 000 person-year,respectively.The cumulative incidence of IBD increased with the rise in TyG,and Log-rank test results showed differences in cumulative incidence between groups(<i>P</i><0.001).After adjusting the confounding factors,the <i>HR</i>(95%<i>CI</i>)of IBD in the TyG2 and TyG3 groups was 1.50(1.21-1.85)and 1.71(1.36-2.16),respectively.The results of the subgroup analysis after adjusting the confounding factors revealed that the <i>HR</i>(95%<i>CI</i>)of ulcerative colitis and Crohn's disease in the TyG3 group was 1.48(1.16-1.74)and 2.27(1.51-3.42),respectively.The sensitive analysis yielded similar results after excluding participants who were diagnosed within one year.Conclusion A high TyG index indicates an increased risk of IBD and its subtypes.</p>","PeriodicalId":6919,"journal":{"name":"中国医学科学院学报","volume":"47 2","pages":"251-258"},"PeriodicalIF":0.0,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143951893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Laparoscopic Sleeve Gastrectomy on Cardiac Structure and Function in Obese Patients With Heart Failure.","authors":"Xiao-Yan Jia, Rui-Jia Lian, Bao-Dong Ma, Yang-Xi Hu, Qin-Jun Chu, Hai-Yun Jing, Zhi-Qiang Kang, Jian-Ping Ye, Xi-Wen Ma","doi":"10.3881/j.issn.1000-503X.16179","DOIUrl":"https://doi.org/10.3881/j.issn.1000-503X.16179","url":null,"abstract":"&lt;p&gt;&lt;p&gt;Objective To investigate the effects of laparoscopic sleeve gastrectomy(LSG)on the cardiac structure and function in obese patients with heart failure(HF)and compare the efficacy of LSG across obese patients with different HF types.Methods This study included 33 obese patients with HF who underwent LSG.The clinical indicators were compared between before operation and 12 months after operation.Repeated measures analysis of variance was employed to evaluate the changes in echocardiographic parameters before operation and 3,6,and 12 months after operation.Patients were allocated into a HF with preserved ejection fraction group(&lt;i&gt;n&lt;/i&gt;=17),a HF with mildly reduced ejection fraction group(&lt;i&gt;n&lt;/i&gt;=5)and a HF with reduced ejection fraction(HFrEF)group(&lt;i&gt;n&lt;/i&gt;=11)based on left ventricular ejection fraction(LVEF)before operation for subgroup analyses of the effects of LSG on the cardiac structure and function of obese patients with HF.The paired samples &lt;i&gt;t&lt;/i&gt;-test was conducted to assess the degree of cardiac structural and functional alterations after LSG.Results The 33 patients included 69.7% males,with an average age of(35.3±9.9)years,and a body mass index(BMI)of(51.2±9.8)kg/m&lt;sup&gt;2&lt;/sup&gt;.The median follow-up was 9.0(5.0,13.3)months.Compared with the preoperative values,the postoperative BMI(&lt;i&gt;P&lt;/i&gt;=0.002),body surface area(BSA)(&lt;i&gt;P&lt;/i&gt;=0.009),waist circumference(&lt;i&gt;P&lt;/i&gt;=0.010),hip circumference(&lt;i&gt;P&lt;/i&gt;=0.031),body fat content(&lt;i&gt;P&lt;/i&gt;=0.007),and percentage of patients with cardiac function grades Ⅲ-IV(&lt;i&gt;P&lt;/i&gt;&lt;0.001)decreased.At the 12-month follow-up left atrial diameter(&lt;i&gt;P&lt;/i&gt;=0.006),right atrial long-axis inner diameter(RAD1)(&lt;i&gt;P&lt;/i&gt;&lt;0.001),right atrial short-axis inner diameter(RAD2)(&lt;i&gt;P&lt;/i&gt;&lt;0.001),right ventricular inner diameter(&lt;i&gt;P&lt;/i&gt;=0.002),interventricular septal thickness at end-diastolic(&lt;i&gt;P&lt;/i&gt;=0.002),and left ventricular end-diastolic volumes(&lt;i&gt;P&lt;/i&gt;=0.004)and left ventricular end-systolic volumes(&lt;i&gt;P&lt;/i&gt;=0.003) all significantly reduced compared with preoperative values.Additionally,left ventricular fractional shortening and LVEF improved(both &lt;i&gt;P&lt;/i&gt;&lt;0.001).Subgroup analyses revealed that cardiac structural parameters significantly decreased in the HF with preserved ejection fraction,HF with mildly reduced ejection fraction,and HFrEF subgroups compared with preoperative values.Notably,the HFrEF group demonstrated the best performance in terms of left atrial diameter(&lt;i&gt;P&lt;/i&gt;=0.003),left ventricular inner diameter at end-diastole(&lt;i&gt;P&lt;/i&gt;=0.008),RAD1(&lt;i&gt;P&lt;/i&gt;&lt;0.001),RAD2(&lt;i&gt;P&lt;/i&gt;=0.004),right ventricular inner diameter(&lt;i&gt;P&lt;/i&gt;=0.019),left ventricular end-diastolic volume(&lt;i&gt;P&lt;/i&gt;=0.004)and left ventricular end-systolic volume(&lt;i&gt;P&lt;/i&gt;=0.001),cardiac output(&lt;i&gt;P&lt;/i&gt;=0.006),tricuspid regurgitation velocity(&lt;i&gt;P&lt;/i&gt;=0.002),and pulmonary artery systolic pressure(&lt;i&gt;P&lt;/i&gt;=0.001) compared to preoperatively.Postoperative left ventricular fractional shortening(&lt;i&gt;P&lt;/i&gt;&lt;0.001,&lt;i&gt;P&lt;/i&gt;=0.003,&lt;i&gt;P&lt;/i&gt;&lt;0.001)and LVEF(&lt;i&gt;P","PeriodicalId":6919,"journal":{"name":"中国医学科学院学报","volume":"47 2","pages":"226-236"},"PeriodicalIF":0.0,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143958234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research Progressin Application of Ultrasound in the Diagnosis and Treatment of Greater Trochanteric Pain Syndrome.","authors":"Fan Wu, Yi Mao, Chun-Bao Li, Long-Tao Yan, Ming-Bo Zhang","doi":"10.3881/j.issn.1000-503X.16095","DOIUrl":"https://doi.org/10.3881/j.issn.1000-503X.16095","url":null,"abstract":"<p><p>Greater trochanteric pain syndrome(GTPS)is a disease caused by structural lesions of the muscles,fascia,ligaments,and bursae near the greater trochanter of the femur.GTPS causes lateral hip joint pain,severely affecting patients' quality of life.Ultrasound has many advantages,such as real-time diagnosis,portable operation,non-radiation,and high resolution,demonstrating a high application value in the diagnosis and interventional therapy of GTPS.This article reviews the current status of ultrasound in the diagnosis and interventional therapy of GTPS and prospects its application.</p>","PeriodicalId":6919,"journal":{"name":"中国医学科学院学报","volume":"47 2","pages":"289-294"},"PeriodicalIF":0.0,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143959131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Afzelin on 2,4,6-Trinitrobenzene Sulfonic Acid-Induced Colitis in Mice.","authors":"Zhi-Jun Geng, Li-Xia Yin, Min-Zhu Niu, Jing-Jing Yang, Xiao-Feng Zhang, Jing Li","doi":"10.3881/j.issn.1000-503X.16122","DOIUrl":"https://doi.org/10.3881/j.issn.1000-503X.16122","url":null,"abstract":"<p><p>Objective To investigate the role and mechanism of afzelin(AFZ)in treating Crohn's disease-like colitis.Methods A mouse model of 2,4,6-trinitrobenzene sulfonic acid-induced colitis was established to assess the effect of AFZ on experimental colitis <i>in vivo</i>.A Caco-2 cell model of tumor necrosis factor(TNF)-α-induced inflammation was established to evaluate the effects of AFZ on the intestinal barrier function,intestinal epithelial cell apoptosis,and mitochondrial function <i>in vitro</i>.The animal and cell experiments were performed to validate the regulatory role of the adenosine monophosphate-activated protein kinase(AMPK)/silent information regulater 1(SIRT1)/peroxisome proliferator-activated receptor gamma coactivator(PGC)-1α pathway in the treatment of colitis with AFZ.Results AFZ reduced the disease activity index(<i>P</i>=0.003),weight loss(<i>P</i><0.001),colon shortening(<i>P</i><0.001),inflammation score(<i>P</i>=0.002),pro-inflammatory cytokine release(interleukin-6:<i>P</i><0.001;TNF-α:<i>P</i>=0.010),and intestinal barrier permeability(fluorescein isothiocyanate dextran 4:<i>P</i><0.001;intestinal-type fatty acid-binding protein:<i>P</i>=0.013).Meanwhile,AFZ increased the colonic transepithelial electric resistance(<i>P</i>=0.001),reduced bacterial translocation(<i>P</i><0.001),and promoted the localization and up-regulated the expression of tight junction proteins [zonula occluden-1(<i>P</i>=0.005) and Claudin-1(<i>P</i>=0.024)].AFZ exerted a protective effect on the Caco-2 cells exposed to TNF-α in terms of intestinal epithelial cell permeability(<i>P</i>=0.017),transepithelial electric resistance(<i>P</i>=0.014),and tight junction protein[zonula occluden-1(<i>P</i>=0.014) and Claudin-1(<i>P</i>=0.006)] localization and expression.Furthermore,the cell and animal experiments confirmed that AFZ reduced the percentage of apoptosis(<i>P</i><0.001,<i>P</i>=0.013)and the expression of cleaved-caspase 3(<i>P</i>=0.028,<i>P</i>=0.004)and Bax(<i>P</i>=0.004,<i>P</i>=0.020),and upregulated the Bcl2(<i>P</i>=0.020,<i>P</i>=0.006)level in intestinal epithelial cells.Additionally,AFZ increased the number of mitochondria,mitochondrial membrane potential,and copy number of mitochondrial DNA(<i>P</i>=0.007)in intestinal epithelial cells,while enhancing the activities of mitochondrial respiratory chain complex Ⅰ(<i>P</i>=0.005)and complex Ⅳ(<i>P</i>=0.001).The activation of the AMPK/SIRT1/PGC-1α pathway was involved in the protective effects of AFZ on mitochondrial function and apoptosis in intestinal epithelial cells.Conclusion AFZ alleviates mitochondrial dysfunction and apoptosis in intestinal epithelial cells by activating the AMPK/SIRT1/PGC-1α pathway,thereby ameliorating intestinal barrier dysfunction and experimental colitis.</p>","PeriodicalId":6919,"journal":{"name":"中国医学科学院学报","volume":"47 2","pages":"207-218"},"PeriodicalIF":0.0,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143951678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research Progress in the Anti-Inflammatory Effect of Exercise in Ameliorating Neuroinflammation-Related Depression.","authors":"Zhi-Xin Zhang, Qi Guo, Xiao-Yu Chen","doi":"10.3881/j.issn.1000-503X.15991","DOIUrl":"https://doi.org/10.3881/j.issn.1000-503X.15991","url":null,"abstract":"<p><p>Depression is an affective disorder caused by multiple factors,and its pathogenesis is still unclear.However,in recent years,studies have found an association between neuroinflammation and depression,which is mainly reflected in the interaction of their pathogeneses,such as abnormalities of monoamine neurotransmitters in the brain,dysregulation of the hypothalamic-pituitary-adrenal axis,and dysfunction of neurogenesis.Currently,exercise as a therapy for depression has attracted widespread attention.By reviewing relevant research reports,this article summarizes that exercise alleviates neuroinflammation by playing an anti-inflammatory role,thus improving the mood-related pathway to treat depression.Furthermore,this article explores the effects of different exercise prescriptions on the anti-inflammatory role of exercise,aiming to provide new scientific ideas for the treatment of depression associated with neuroinflammation.</p>","PeriodicalId":6919,"journal":{"name":"中国医学科学院学报","volume":"47 2","pages":"191-197"},"PeriodicalIF":0.0,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143951915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Langerhans Cell Histiocytosis of Bone:Report of Eight Cases and Review of the Literature.","authors":"Ya Bi, Dan-Dan Wu, Fang-Ying Yu, Zhen-Hong Fang, Bo Huang","doi":"10.3881/j.issn.1000-503X.16077","DOIUrl":"https://doi.org/10.3881/j.issn.1000-503X.16077","url":null,"abstract":"<p><p>Langerhans cell histiocytosis of bone is a rare tumor disease characterized by the large accumulation of CD1a⁺ and CD207⁺ dendritic cells in tissues of unknown cause.It mainly occurs in children aged 1-4 years old,with incidences of 4-6 per million in children and 1-2 per million in adults.Due to its low incidence,diverse clinical manifestations,and no obvious specificity of imaging manifestations,the definitive diagnosis and early treatment of this type of tumor are challenging.In this paper,we report 8 cases of Langerhans cell histiocytosis of bone and review the relevant literature published in the past five years to summarize the clinical characteristics,pathological features,diagnosis,treatment,and prognosis of this disease.</p>","PeriodicalId":6919,"journal":{"name":"中国医学科学院学报","volume":"47 2","pages":"325-332"},"PeriodicalIF":0.0,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143962216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physical Function Characteristics of Elderly Women With Fall Experiences.","authors":"Ya-Fei Duan, De-Wen Ji, Tao Fu, Zhu-Qing Dong","doi":"10.3881/j.issn.1000-503X.16290","DOIUrl":"https://doi.org/10.3881/j.issn.1000-503X.16290","url":null,"abstract":"<p><p>Objective To explore the physical function indicators of elderly women with fall experiences,so as to provide more data reference for fall prevention,risk assessment,and solving of aging-related health problems in elderly women.Methods The fall history of 167 elderly women in communities in Tianjin was investigated by a questionnaire.The participants were assigned into a fall group(more than 2 falls in the last 1 year)and a non-fall group according to the number of falls.Body composition was tested by an Inbody 770 Body Composition Analyzer,and the calcaneus bone mineral density was measured by a UBD2002A Ultrasound Bone Densitometer.The muscle strength and proprioception of knee and ankle joints of lower limbs were measured by a PRIMUS BTE Isokinetic Tester.The muscle strength of lower limbs was evaluated by the number of 30-second sitting-rising.The visual sensitivity was examined by two-contrast near point reading cards(with a small number of strokes).The dynamic and static balance abilities were determined by a Korebalance Tester,and the static balance ability was tested by one-leg standing with eyes closed.The dynamic and static balance was assessed based on the Berg balance scale,and walking gait characteristics were studied by a BTS three-dimensional motion capture system.Results The skeletal muscle content(<i>P</i><0.001),strength of non-dominant knee flexor muscle(<i>P</i>=0.002),number of 30-second sitting-rising(<i>P</i>=0.006),and average walking speed(<i>P</i>=0.013)in the fall group were lower than those in the non-fall group.The visual acuity at 10% grayscale(<i>P</i>=0.001),active knee joint position sense(<i>P</i><0.001),strength of non-dominant ankle flexor muscle(<i>P</i><0.001),and one-leg standing time with eyes closed(<i>P</i><0.001)in the fall group were lower than those in the non-fall group.The fall group outperformed the non-fall group in right-left balance rate(<i>P</i>=0.031)and forward-backward balance rate(<i>P</i>=0.028)during static and dynamic balance tests.Conclusion The ankle angle,proprioception,muscle strength,and skeletal muscle content of lower limbs,visual sensitivity,dynamic and static balance abilities,and walking ability of elderly women with fall experiences were lower than those without fall experiences.</p>","PeriodicalId":6919,"journal":{"name":"中国医学科学院学报","volume":"47 2","pages":"182-190"},"PeriodicalIF":0.0,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143957335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}