中国医学科学院学报最新文献

{"title":"Expert Consensus on the Artificial Intelligence Proficiency Competency List and Assessment Framework for Medical Students (2025 Edition).","authors":"Meng-Chun Gong, Hui Pan, Hui Liu, Kuang Tong, Jiao Li, Yong-Hui Ma, Wei Chen, Yan Hou, Li Hong, Bo Zhang, Bo-Han Zhang, Zhi-Rong Zeng, Xun-Ming Ji","doi":"10.3881/j.issn.1000-503X.17210","DOIUrl":"10.3881/j.issn.1000-503X.17210","url":null,"abstract":"<p><p>To cultivate composite medical professionals capable of adapting to the development of intelligent healthcare,this consensus is grounded in the competency-based medical education,integrating the competency model and Miller's pyramid of clinical competence. A two-round Delphi method involving a multidisciplinary expert panel was conducted,combined with a systematic literature review,to develop a 21-indicator artificial intelligence(AI) literacy competency list for medical students across three domains:knowledge (8 indicators),skills (8 indicators),and attitudes (5 indicators). Furthermore,the consensus proposes a practical assessment system:standardized testing for the knowledge domain,situational judgment tests for the attitudes domain,and objective structured clinical examinations incorporating AI-related scenarios for the skills domain. In addition,a longitudinal assessment strategy spanning the phases of admission,preclinical training,and clinical training is recommended. The competency list and assessment framework established in this consensus demonstrate strong scientific rigor,authority,and practical applicability,and can serve as an important reference for medical schools seeking to advance the deep integration of AI and medical education and to cultivate composite medical talents suited to the era of intelligent healthcare.</p>","PeriodicalId":6919,"journal":{"name":"中国医学科学院学报","volume":" ","pages":"13-23"},"PeriodicalIF":0.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146123423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Visual Analysis of Research Status and Trends in Relationship Between Circadian Rhythm and Obesity.","authors":"Zi-Yi Luo, Yu-Ni Wang, Guo-Tao Fan, Ming-Jun Zhong, Wu-Zheng Liu, Jia-Hui Li, Bei-Lin Chen, Xiao-Lin Cai, Yi-Hang Li, Zhen-Jie Wang, Wen-Qi Zeng, Jin-Jin Wang, Yi-Kuan DU, Chun Yang","doi":"10.3881/j.issn.1000-503X.16611","DOIUrl":"https://doi.org/10.3881/j.issn.1000-503X.16611","url":null,"abstract":"<p><p>Objective To analyze the research bases,research hotspots,and future research trends in the relationship between the circadian rhythm and obesity,thus providing a reference for research in this field. Methods Literature on obesity and circadian rhythm published from 2001 to June 2024 was retrieved from the Web of Science.CiteSpace and VOSviewer were used for scientometric analysis. Results This study included 1 185 publications from 4 083 organizations in 354 countries/regions.Annual number of publications in this field showed an overall upward trend,with particularly rapid growth after 2019.Countries such as the United States and Ireland exerted significant influence in this field.Keyword co-occurrence and cluster analysis identified adipose tissue and meal timing as closely related keywords.The burst analysis indicated gut microbiota and DNA methylation as current research hotspots. Conclusions The research on the association between circadian rhythm and obesity primarily centers on the interaction between circadian rhythm and gut microbiota,which influences lipid metabolism processes,and on the regulation of circadian rhythm through meal timing to reduce obesity risk.Incorporating epigenetics in the research on circadian rhythm and obesity may represent an important future research direction.</p>","PeriodicalId":6919,"journal":{"name":"中国医学科学院学报","volume":"48 1","pages":"128-136"},"PeriodicalIF":0.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147508546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Primary Central Nervous System Lymphoma With the First Onset in the Spinal Cord: Report of One Case and Literature Review.","authors":"Li Zhang, Zi-Wang Han, Sai Gao, Lei Wu, De-Hui Huang","doi":"10.3881/j.issn.1000-503X.16725","DOIUrl":"https://doi.org/10.3881/j.issn.1000-503X.16725","url":null,"abstract":"<p><p>Primary central nervous system lymphoma(PCNSL)is a non-Hodgkin's lymphoma confined to the brain parenchyma,spinal cord,pia mater,and eyes.It has diverse clinical manifestations and is extremely difficult to diagnose.Spinal cord involvement is particularly rare.This article reports a case of PCNSL with the first onset in the spinal cord and elaborates on the important diagnostic roles of MRI,whole-body PET/CT,and cerebrospinal fluid interleukin-10 in PCNSL,aiming to improve the clinical understanding of this condition,increase the early diagnosis rate,and improve the prognosis.</p>","PeriodicalId":6919,"journal":{"name":"中国医学科学院学报","volume":"48 1","pages":"185-191"},"PeriodicalIF":0.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147508691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research Progress on the Role of Basolateral Amygdala in Sleep and Anesthesia-Induced Alterations in Consciousness.","authors":"Xin-Yu Yuan, Yi Zhang, Cheng-Dong Yuan","doi":"10.3881/j.issn.1000-503X.16591","DOIUrl":"https://doi.org/10.3881/j.issn.1000-503X.16591","url":null,"abstract":"<p><p>Basolateral amygdala(BLA),an important component of the amygdala,has become a key region in the study of the regulation of anesthesia and the sleep-wake cycle in recent years.In addition to the role in the regulation of emotions and behaviors,BLA regulates the depth of anesthesia and affects the recovery from anesthesia through the interactions of a variety of neurotransmitters and neural circuits.Moreover,BLA mediates the transition of the sleep-wake state to affect the sleep duration.It has been demonstrated that BLA plays an extremely important role in the neurobiological mechanisms of anesthesia and sleep.This paper reviews the recent research progress in the roles of BLA in anesthesia and sleep-wake regulation,aiming to provide a new perspective for deeply understanding the function of BLA and offer a potential theoretical basis for improving clinical anesthetic outcome and sleep quality.</p>","PeriodicalId":6919,"journal":{"name":"中国医学科学院学报","volume":"48 1","pages":"137-143"},"PeriodicalIF":0.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147508783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reflection on Discipline Construction of Palliative Medicine in China From Knowledge and Institutional Dimensions.","authors":"Qian Liu, Ying Tang","doi":"10.3881/j.issn.1000-503X.16920","DOIUrl":"https://doi.org/10.3881/j.issn.1000-503X.16920","url":null,"abstract":"<p><p>We examine the status and path of the discipline construction of palliative medicine from both knowledge and institutional dimensions.From the knowledge dimension,palliative medicine is driven by the demand of the times and has significant interdisciplinary characteristics.From the institutional dimension,the development direction of palliative medicine remains to be clarified,despite the established foundation.It is recommended that the boundaries of palliative medicine,hospice care and other secondary disciplines of clinical medicine be clearly defined from the knowledge dimension.From the institutional dimension,establishing a pilot master's degree program in palliative care is proposed as a key breakthrough,and the collaboration of multiple stakeholders should be promoted to advance the institutionalization and knowledge innovation of this discipline.</p>","PeriodicalId":6919,"journal":{"name":"中国医学科学院学报","volume":"48 1","pages":"45-51"},"PeriodicalIF":0.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147508839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Pressure-Controlled Ventilation-Volume Guaranteed on Pulmonary Oxygenation Function in Patients Undergoing Off-Pump Coronary Artery Bypass Grafting.","authors":"Xiao-Yong Wei, Fang-Hua Chen, Jun Li, Na Zhao, Rui Qin, Rui Yan, Xin-Li Ni","doi":"10.3881/j.issn.1000-503X.16975","DOIUrl":"10.3881/j.issn.1000-503X.16975","url":null,"abstract":"<p><p>Objective To evaluate the effect of pressure-controlled ventilation-volume guaranteed(PCV-VG)on the perioperative pulmonary oxygenation function of the patients undergoing off-pump coronary artery bypass grafting(OPCABG). Methods Forty patients aged 40-65 years,of both sexes,with the American Society of Anesthesiologists physical status Ⅲ or Ⅳ,preoperative cardiac function(NYHA)class Ⅱ or Ⅲ,scheduled for elective OPCABG were assigned via the random number table method into two groups(<i>n</i>=20):a volume-controlled ventilation(VCV)group(Group V)and a PCV-VG group(Group P).Other respiratory parameters of the anesthesia machine were set consistently in both groups.At the time of sawing the sternum(T₀),when left internal mammary artery harvesting with the operating table tilted 10° to the left(T₁),when left anterior descending coronary artery bypass grafting with the operating table tilted 10° to the right(T₂),when right coronary artery bypass grafting with the operating table in a 30° head-down and tilted 10° to the right(T₃),when circumflex coronary artery bypass grafting with the operating table in a 20° head-down and tilted 15° to the right(T₄),and at the end of the surgery(T₅),the peak airway pressure(Ppeak),mean airway pressure(Pmean),plateau airway pressure(Pplat),and pulmonary dynamic compliance(Cdyn)were recorded.The alveolar-arterial partial pressure difference of oxygen(PA-aDO₂),oxygenation index(OI),and respiratory index(RI)were recorded at the aforementioned time points as well as on postoperative day 1(T₆),day 3(T₇),and day 7(T₈).The dosages of intraoperative drugs(sufentanil,remifentanil,and rocuronium bromide),postoperative endotracheal tube indwelling time,the stay time in the cardiac surgery intensive care unit,and the occurrence of pulmonary complications within 7 days after the surgery were also recorded. Results Compared with Group V,Group P showed significant downward trends in Ppeak,Pmean,and Pplat during T₃-T₅,as well as in PA-aDO₂ and RI during T₃-T₈(all <i>P</i><0.05).Meanwhile,Group P exhibited significant upward trends in Cdyn during T₃-T₅ and in OI during T₃-T₈(all <i>P</i> <0.05).Compared with those in Group V,the postoperative endotracheal tube indwelling time and the stay time in the cardiac surgery intensive care unit were shortened in Group P(all <i>P</i><0.05).There was no statistically significant difference in dosages of intraoperative drugs(sufentanil,remifentanil,and rocuronium bromide)or incidence of pulmonary complications within 7 days after the surgery between the two groups of patients(all <i>P</i>>0.05). Conclusion Compared with VCV,PCV-VG can improve the perioperative pulmonary oxygenation function of the patients undergoing OPCABG.</p>","PeriodicalId":6919,"journal":{"name":"中国医学科学院学报","volume":" ","pages":"120-127"},"PeriodicalIF":0.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145761860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Triggers of Differences in the Anti-Contractile Function of Perivascular Adipose Tissue in the Thoracic and Abdominal Aorta.","authors":"Er-Ling Guo","doi":"10.3881/j.issn.1000-503X.16586","DOIUrl":"https://doi.org/10.3881/j.issn.1000-503X.16586","url":null,"abstract":"<p><p>Perivascular adipose tissue(PVAT)is a novel type of adipose tissue distinct from visceral fat.It releases adipokines with vasoconstrictive functions,which regulate vascular functions through paracrine and endocrine mechanisms.PVAT exhibits regional phenotypic differences in different parts of the vasculature bed,which may lead to heterogeneity in the secretion profiles and norepinephrine(NE)content among different regions of PVAT and subsequently affect the regulation of specific adipokine signaling pathways,resulting in differences in vascular function among different regions.This review summarizes the factors influencing the differences in the anti-contractile function of PVAT in different regions,including the origins of adipocytes and heterogeneity of regional PVAT,the anti-contractile function mediated by endothelial nitric oxide synthase(eNOS),the activity of the adiponectin-eNOS pathway,and the concentration of NE,aiming to provide new ideas for clinical diagnosis and research.</p>","PeriodicalId":6919,"journal":{"name":"中国医学科学院学报","volume":"48 1","pages":"177-184"},"PeriodicalIF":0.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147508528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Practice and Strategies of Palliative Care Physicians' Agency: An Integrated Narrative and Observational Study.","authors":"Cui-Wen Fa, Xu Li, Tie-Kuan DU, Xi Ding, Xiao-Hong Ning, Jia-Xin Zhou, Fei Yang, Min Song, Ting-Jun Yong","doi":"10.3881/j.issn.1000-503X.16923","DOIUrl":"https://doi.org/10.3881/j.issn.1000-503X.16923","url":null,"abstract":"<p><p>Objective To explore how physicians exercise agency in palliative care under cultural,technological,and institutional constraints. Methods This study integrated death narratives with participatory observation in a palliative care center of a tertiary hospital in Beijing and systematically analyzed the data by reflexive thematic analysis. Results Physicians faced three structural constraints:medical familism at the cultural level,which hindered information sharing and patient autonomy;a technology-first tendency leading to overtreatment and misaligned goals;and institutional resource shortages with marginalized values.In response,they employed three key agency strategies:acting as communication mediators to build trust;serving as decision navigators to refocus families on patient interests;and coordinating care networks to address psychosocial and spiritual needs. Conclusions Physicians demonstrate contextual and strategic agency in palliative care,creating space to improve care under structural constraints.This study provides empirical support for localized practice and highlights the need for institutional reinforcement of physician agency.</p>","PeriodicalId":6919,"journal":{"name":"中国医学科学院学报","volume":"48 1","pages":"65-72"},"PeriodicalIF":0.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147508716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Responding to Suffering:Development Course and Social Dimensions of Palliative Care.","authors":"Jing-Wen Fang","doi":"10.3881/j.issn.1000-503X.16902","DOIUrl":"https://doi.org/10.3881/j.issn.1000-503X.16902","url":null,"abstract":"<p><p>A review of the development course of palliative care reveals that its goal of alleviating suffering determines the indispensability of the social dimension in this field.As palliative care emerges in response to the general trends such as aging and disease spectrum changes of social development,it naturally becomes one of the key solutions to social issues including the difficulties in caregiving and hospitalization for end-of-life patients.Beyond its social value,the comprehensiveness and localization of care emphasized by palliative care also require the support and intervention of theoretical perspectives such as social support and sociocultural adaptation.Through the framework of suffering and care,medicine and social sciences have achieved significant interdisciplinary integration in palliative care.</p>","PeriodicalId":6919,"journal":{"name":"中国医学科学院学报","volume":"48 1","pages":"52-58"},"PeriodicalIF":0.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147508820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Roles,Effects,and Elements of Palliative Care Development in General Hospitals Based on the Consolidated Framework for Implementation Research.","authors":"Yao-Xin Zeng, Zi-Dan Wang, Peng Yue, Xiao-Hong Ning, Ying Zheng, Xiao-Yan Dai, Tie-Kuan DU, Zhi-Meng Jia","doi":"10.3881/j.issn.1000-503X.16858","DOIUrl":"https://doi.org/10.3881/j.issn.1000-503X.16858","url":null,"abstract":"<p><p>Objective To analyze the roles,effects,and key elements of palliative care development in Peking Union Medical College Hospital based on the Consolidated Framework for Implementation Research(CFIR),thus providing a reference for the development of palliative care in other general hospitals. Methods Semi-structured interviews and observation were employed to collect data,which were analyzed and coded in accordance with the CFIR. Results More than 35 000 words were written in the observation diary and 11 subjects were interviewed.A total of 64 codes were extracted,which were categorized into 26 entries in five domains:innovation,external factors,internal factors,individual domains,and implementation process. Conclusion The palliative care model of Peking Union Medical College Hospital has a high degree of generalizability,and it can help general hospitals to explore a palliative care model that is suitable for their own situation.</p>","PeriodicalId":6919,"journal":{"name":"中国医学科学院学报","volume":"48 1","pages":"73-80"},"PeriodicalIF":0.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147508522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}