中国医学科学院学报最新文献

{"title":"Opportunities and Challenges in the Development of Narrative Medicine.","authors":"Ming-Ming Zou","doi":"10.3881/j.issn.1000-503X.17402","DOIUrl":"https://doi.org/10.3881/j.issn.1000-503X.17402","url":null,"abstract":"<p><p>It has been 15 years since the introduction of narrative medicine into China.The growing of medical humanistic demand,the gradual improvement of industry recognition,and the continuous support of relevant national policies have provided good opportunities for the development of narrative medicine.The current development of narrative medicine faces both opportunities and challenges.The continuous accumulation of favorable conditions provides strong support for the standardized promotion of narrative medicine,while there are still obvious shortcomings,mainly manifested in the weak foundation of the discipline and the unclear path of practice and research.Although the exploration of localization has begun to bear fruit,the overall development still needs to be deepened.China has an improving environment and outstanding potential for the development of narrative medicine.At the same time,it faces many problems such as discipline construction,practical research,and localization deepening,presenting a pattern characterized by coexistence of opportunities and challenges.</p>","PeriodicalId":6919,"journal":{"name":"中国医学科学院学报","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148890728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Teaching Case of Narrative Medicine Integrating Five-Education Innovation: An Exploration of the Full-Cycle Education Model at Sun Yat-sen University.","authors":"Ping-Gan Li, Xiao-Lin Zhou, Yong-Hong Qing, Dun-Hua Zhou, Yu Cheng, Li-Yang Liang","doi":"10.3881/j.issn.1000-503X.17406","DOIUrl":"https://doi.org/10.3881/j.issn.1000-503X.17406","url":null,"abstract":"<p><p>Current medical education faces an imbalance between technical rationality and humanistic spirit,with medical students' empathy declining as their training progresses.Narrative medicine offers a new path for reform.This paper systematically elaborates on the talent cultivation pathway of \"five-dimension education integration and innovation\" constructed by Sun Yat-sen University since 2017 under the guiding principle of five-dimension education (moral,intellectual,physical,aesthetic,and labor education) based on narrative medicine.This study innovatively proposes a teaching framework of \"one body and two wings\" and extends GUO Liping's \"little red flower\" model to construct a \"five-dimension education-little red flower\" interdisciplinary collaborative teaching model,which takes the narrative medicine course cluster as the \"body\" and clinical practice and humanistic experience as the two \"wings,\" achieving deep integration of the five dimensions of education.At the practical level,a three-stage progressive closed loop of \"sprouting-deepening-transformation\" has been established,with a four-step teaching method of \"demonstration analysis-collaborative writing-independent writing-reflection internalization\" formed at the transformation stage,along with a \"1∶1 interdisciplinary collaboration\" general education course for all first-year students.Teaching evaluations show that the curriculum effectively enhances medical students' empathy and communication initiative,with non-medical students benefiting particularly significantly.This practical model validates and extends the application boundaries of localized narrative medicine theory,realizing a conceptual leap from cultivating \"technical executors\" to nurturing future caregivers\" and providing a practical model and operational experience for reference in the reform of medical humanities education in the context of emerging medical education in China.</p>","PeriodicalId":6919,"journal":{"name":"中国医学科学院学报","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148890702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Construction and Antitumor Efficacy of an Antigen-Adjuvant Self-Carrier Spherical Peptide Nanovaccine.","authors":"Yi-Jie Zhan, Ru-Dan Wang, Ying-Ying Ma, Yi-Tong Sun, Lan-Xia Liu","doi":"10.3881/j.issn.1000-503X.17094","DOIUrl":"10.3881/j.issn.1000-503X.17094","url":null,"abstract":"<p><p>Objective To construct a novel carrier-free nanovaccine to trigger a strong anti-tumor immune effect in the body. Methods The Toll-like receptor 4 agonist monophosphoryl lipid A （MPLA） was covalently conjugated with mucin 1 （MUC1）-targeting amino acid motif （Maa） to form MPLA-Maa monomer molecules.Subsequently，MPLA-Maa was self-assembled with Leu-His modified MUC1 polypeptide （LMP） to construct the nanovaccine system （MAP NVs）. Results MAP NVs exhibited a particle size of （169.85±4.05） nm，a polydispersity index of 0.308±0.021，and the Zeta potential of （-19.10±1.00） mV，and remained stable <i>in vitro</i> for over 10 days.Cell experiments showed that the nanovaccine significantly promoted dendritic cell maturation and activation and promoted tumor necrosis factor-α secretion.In the B16-MUC1 melanoma model，MAP NVs demonstrated remarkable antitumor effects，significantly inhibiting tumor growth and prolonging the survival of tumor-bearing mice.Mechanism analysis further revealed that MAP NVs effectively activated T cell immune response，promoted the proliferation of CD4⁺ and CD8⁺ T cells，and induced the production of CD8⁺ central memory T cells.After antigen restimulation，the secretion levels of tumor necrosis factor-α and interferon-γ were significantly elevated，which indicated long-lasting immune memory. Conclusions A carrier-free spherical peptide nanovaccine based on the co-delivery strategy of MPLA and LMP was successfully constructed.By promoting dendritic cell activation and enhancing T cell immune response，this system exhibits significant antitumor activity and long-lasting immune memory effect.This study provides a new technical approach and an experimental basis for developing nanovaccines against tumors.</p>","PeriodicalId":6919,"journal":{"name":"中国医学科学院学报","volume":"48 4","pages":"607-617"},"PeriodicalIF":0.0,"publicationDate":"2026-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148838810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current Situation and Influencing Factors of Parents' Knowledge，Attitudes，and Practice of Childhood Sexuality Education in Xichang City.","authors":"Si-Ying Chen, Jun-Hong Yang, Qin Xiao, Ke-Xin Li, Yun-Li Ye","doi":"10.3881/j.issn.1000-503X.16922","DOIUrl":"10.3881/j.issn.1000-503X.16922","url":null,"abstract":"<p><p>Objective To understand the current situation and influencing factors of knowledge，attitudes，and practice of childhood sexuality education among parents in Xichang city，thus providing a basis for improving the current situation of childhood sexuality education and promoting related work of family sexuality education. Methods Through cluster random sampling，8 kindergartens were selected in Xichang city，Sichuan province.A self-designed questionnaire on parents' knowledge，attitudes，and practice of childhood sexuality education was used to conduct an anonymous survey on parents of young children who were selected from the kindergartens.The data were analyzed by chi-square test and multivariate Logistic regression model. Results The rates of knowledge awareness，positive attitude，and good practice among the 1 496 parents were 3.9%，32.0%，and 36.6%，respectively，and the overall good rate of knowledge，attitudes，and practice was 22.9%.The results of multivariate Logistic regression analysis showed that parents who were of Han ethnicity （<i>OR</i>=1.73，95%<i>CI</i>=1.17-2.56，<i>P</i>=0.006），whose children were female （<i>OR</i>=2.16，95%<i>CI</i>=1.51-3.11，<i>P</i>=0.019），who believed that sexuality education should be the responsibility of parents （<i>OR</i>=2.42，95%<i>CI</i>=1.57-3.73，<i>P</i><0.001），who had communicated with family and friends about childhood sexuality education （<i>OR</i>=2.95，95%<i>CI</i>=2.22-3.92，<i>P</i><0.001），and who had conducted sexuality education for their children themselves （<i>OR</i>=1.81，95%<i>CI</i>=1.37-2.40，<i>P</i><0.001） had higher overall good rates of knowledge，attitudes，and behavior in childhood sexuality education. Conclusions Parents generally have low rates of knowledge awareness，positive attitudes，and good practice and a low overall good rate of knowledge，attitudes，and practice regarding childhood sexuality education.Relevant departments should attach importance to childhood sexuality education，with a particular focus on parents of ethnic minorities and those who have not carried out childhood sexuality education.They should intensify publicity and training efforts to enhance parents' level of sexuality education，change their attitudes towards sexuality education，and promote the development of family sexuality education.</p>","PeriodicalId":6919,"journal":{"name":"中国医学科学院学报","volume":"48 4","pages":"647-652"},"PeriodicalIF":0.0,"publicationDate":"2026-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148838777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>In Vitro</i> Litholytic Effects of Three Chinese Herbal Extracts on Mixed-Type Urinary Calculi.","authors":"Sha-Sha Xia, Jun Shen, Kai-Wen Shen, Yao-Ke Li, Hong Yang","doi":"10.3881/j.issn.1000-503X.17009","DOIUrl":"10.3881/j.issn.1000-503X.17009","url":null,"abstract":"<p><p>Objective To preliminarily investigate the litholytic effects of extracts from Lysimachiae Herba，Selaginellae Herba （<i>Selaginella pulvinata</i>），and Phragmitis Rhizoma on mixed-type urinary calculi （calcium oxalate/carbonate apatite） through <i>in vitro</i> experiments. Methods A total of 264 surgically extracted renal calculus specimens were collected.Compositional analysis was performed through infrared spectroscopy.Extracts of the three herbal medicines were prepared，and their litholytic effects on mixed-type calculi （calcium oxalate/carbonate apatite） were evaluated via <i>in vitro</i> litholysis assays，with normal saline as the negative control. Results Among the 264 calculus specimens，mixed-type calculi exhibited the highest prevalence （52.27%，138/264），of which the calcium oxalate/carbonate apatite subtype accounted for 63.77% （88/138） of mixed calculi.All the three extracts significantly dissolved the mixed-type calculi （all <i>P</i><0.001），with the efficacy ranking as follows：Lysimachiae Herba>Selaginellae Herba>Phragmitis Rhizoma，with statistically significant intergroup differences （<i>P</i><0.001）. Conclusions Mixed-type calculi predominate in urolithiasis patients，with calcium oxalate/carbonate apatite being the most common subtype.Extracts of Lysimachiae Herba and Selaginellae Herba demonstrate superior <i>in vitro</i> litholytic effects on this mixed-type calculus subtype，suggesting their potential as therapeutic agents for clinical management of urolithiasis.</p>","PeriodicalId":6919,"journal":{"name":"中国医学科学院学报","volume":"48 4","pages":"686-693"},"PeriodicalIF":0.0,"publicationDate":"2026-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148838783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between the Non-High-Density Lipoprotein/High-Density Lipoprotein Cholesterol Ratio and Sarcopenia in Older Chinese Men.","authors":"Jin-Jiang Li, Chun-Yan Hao","doi":"10.3881/j.issn.1000-503X.17026","DOIUrl":"10.3881/j.issn.1000-503X.17026","url":null,"abstract":"<p><p>Objective To investigate the association between the non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio （NHHR） and the risk of sarcopenia in older Chinese men. Methods This study was based on the baseline data from the China Health and Retirement Longitudinal Study，including 1 849 men aged≥60 years.Missing data were handled through multiple imputation.Participants were categorized into quartiles of NHHR （Q1-Q4）.Multivariable Logistic regression models were constructed with stepwise adjustment for demographic factors，lifestyle，chronic diseases，and body mass index （BMI） to estimate odds ratios （<i>OR</i>） and 95%<i>CI</i>.Restricted cubic spline analysis was performed to examine potential non-linear associations.Subgroup and sensitivity analyses （with possible sarcopenia as an alternative outcome） were performed. Results NHHR was significantly and inversely associated with sarcopenia.In models without BMI adjustment，the highest NHHR quartile （Q4） showed a lower risk of sarcopenia than the lowest quartile （Q1） （<i>OR</i>=0.199，95%<i>CI</i>=0.112-0.338，<i>P</i><0.001）.However，the association was attenuated after adjustment for BMI （<i>OR</i>=0.403，95%<i>CI</i>=0.220-0.709，<i>P</i>=0.002；the <i>OR</i> for each 1-standard-deviation increase in NHHR was approximately 0.680）.Restricted cubic spline analysis indicated a linear association （<i>P</i>_overall<0.001，<i>P</i>_non-linear=0.793）.In sensitivity analyses，NHHR remained significantly and inversely associated with possible sarcopenia.The fully adjusted model showed that the risk of possible sarcopenia was lower in the Q4 group than in the Q1 group （<i>OR</i>=0.613，95%<i>CI</i>=0.404-0.924，<i>P</i>=0.020），and each 1-standard-deviation increase in NHHR was associated with a reduced risk of possible sarcopenia （<i>OR</i>=0.849，95%<i>CI</i>=0.728-0.987，<i>P</i>=0.035）.Subgroup analyses showed that the inverse association between NHHR and sarcopenia risk was directionally consistent across strata of age，smoking，drinking，and hypertension，while the association in the diabetes subgroup did not reach statistical significance，possibly owing to the limited sample size （<i>OR</i>=0.46，95%<i>CI</i>=0.16-1.37，<i>P</i>=0.164）. Conclusions NHHR is inversely associated with sarcopenia risk among older Chinese men，while this association is substantially attenuated after adjustment for BMI，suggesting it may be largely confounded by body size or obesity-related factors.These findings should be interpreted with caution，and future longitudinal studies incorporating direct muscle mass measurements，such as dual-energy X-ray absorptiometry and bioelectrical impedance analysis，are warranted to clarify the independent role of NHHR in sarcopenia.</p>","PeriodicalId":6919,"journal":{"name":"中国医学科学院学报","volume":"48 4","pages":"660-670"},"PeriodicalIF":0.0,"publicationDate":"2026-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148838799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dignified Death in China：Dilemmas and Reflections.","authors":"Long Chen","doi":"10.3881/j.issn.1000-503X.16945","DOIUrl":"10.3881/j.issn.1000-503X.16945","url":null,"abstract":"<p><p>The implementation of dignified death in China faces multiple practical obstacles.Economic conditions，resource allocation，cultural values and other social factors profoundly shape different groups' understanding and implementation of dignified death.Against this background，the factors directly constraining its practice are concentrated in several areas：the value tension between traditional filial piety ethics and the concept of self-determination in life，theoretical disagreements and the dilemma of balancing interests at the end of life，the inherent role conflict of physicians and the blurred boundaries of their legal liability，the challenge of verifying patients' decision-making capacity and the authenticity of their wishes，and dificiencies in the supply of hospice care resources and service systems.Analysis indicates that the practice of dignified death in China remains inadequate，and its transition from conceptual recognition to practical application is systematically constrained by the above multiple factors.The key to advancing this process lies in achieving a positive interaction between values and institutions.Thus，a thorough understanding of the difficulties encountered in the local exploration of dignified death，along with corresponding adjustment in societal attitudes and institutional coordination，constitutes the prerequisite and foundation for moving it toward practice.</p>","PeriodicalId":6919,"journal":{"name":"中国医学科学院学报","volume":"48 4","pages":"694-701"},"PeriodicalIF":0.0,"publicationDate":"2026-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148838852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasound-Guided Peripheral Nerve Pulsed Radiofrequency Combined With Platelet-Rich Plasma Injection for Complex Regional Pain Syndrome：Report of One Case.","authors":"Qing Yuan, Jin Wang, Yi Zhang, Xu-Lei Cui","doi":"10.3881/j.issn.1000-503X.17212","DOIUrl":"10.3881/j.issn.1000-503X.17212","url":null,"abstract":"<p><p>Complex regional pain syndrome is a refractory disease characterized by complex pathogenesis，severe chronic pain，and autonomic nervous system dysfunction.This article reports a 26-year-old female patient who presented with severe，electric shock-like pain and hyperalgesia in the first toes of both feet following an ankle sprain.In addition，her symptoms included localized redness，swelling，burning sensation，and hyperhidrosis.She was clinically diagnosed with complex regional pain syndrome.After oral pharmacotherapy for neuropathic pain proved ineffective，she was treated with ultrasound-guided pulsed radiofrequency of the medial plantar nerve combined with platelet-rich plasma injection.Postoperative follow-up showed progressive symptom alleviation.One month after the procedure，the pain score decreased to 0，and autonomic symptoms such as local redness，swelling，and abnormal sweating were completely resolved.No recurrence was observed during the six-month postoperative follow-up period.</p>","PeriodicalId":6919,"journal":{"name":"中国医学科学院学报","volume":"48 4","pages":"767-770"},"PeriodicalIF":0.0,"publicationDate":"2026-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148838835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impacts of Copper Metabolism Disorder on Multiple Systems in Menkes Disease.","authors":"Xin-Yi Xu, Ling Jin, Chang-Hong Miao, Zi-Qi Shan, Ying Gao, Lu Xiao","doi":"10.3881/j.issn.1000-503X.16738","DOIUrl":"10.3881/j.issn.1000-503X.16738","url":null,"abstract":"<p><p>Menkes disease is a rare X-linked recessive multisystem copper metabolism disorder first reported in 1962.Recent studies have shown that its incidence and mortality rates may be underestimated due to miscarriages and early deaths.The clinical manifestations of Menkes disease are closely related to copper metabolism disorder，mainly characterized by neurodegeneration and vascular and connective tissue abnormalities.These symptoms stem from copper transport disorders and abnormal activity of copper-dependent enzymes caused by copper metabolism disorder.By integrating clinical symptoms and mechanism analysis，this paper reveals the core role of copper metabolism disorder in the multisystem damage of Menkes disease，providing a theoretical basis for early diagnosis and intervention.</p>","PeriodicalId":6919,"journal":{"name":"中国医学科学院学报","volume":"48 4","pages":"708-716"},"PeriodicalIF":0.0,"publicationDate":"2026-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148838792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Polyphyllin I on Stem Cell Properties of MCF-7 Spheroids and Its Correlation With Hybrid Epithelial-Mesenchymal Transition.","authors":"Tong Liu, Yuan Li","doi":"10.3881/j.issn.1000-503X.17089","DOIUrl":"10.3881/j.issn.1000-503X.17089","url":null,"abstract":"<p><p>Objective To investigate the effect of polyphyllin I on MCF-7 spheroids enriched with cancer stem cells and to preliminarily observe its effect on the hybrid epithelial-mesenchymal transition （EMT） state and its regulatory role on cell stemness. Methods MCF-7 spheroids were cultured under serum-free，non-adherent conditions.Cell viability，invasion，and key protein expression were assessed through the cell counting kit-8 assay，Transwell assay，and Western blot，respectively.The CD44⁺/CD24^-/low cell population was analyzed by flow cytometry. Results The MCF-7 spheroids exhibited high proliferative and invasive capacities，co-expressing the epithelial marker E-cadherin and the mesenchymal marker vimentin，which is indicative of a hybrid EMT state and high stemness.Polyphyllin I treatment significantly suppressed the viability and invasion of MCF-7 spheroids.From a mechanism perspective，polyphyllin I downregulated the E-cadherin/vimentin ratio，significantly reduced the levels of stemness-associated proteins CD44 antigen，aldehyde dehydrogenase 1 family member A1，as well as the ratio of phosphorylated signal transducer and activator of transcription 3 to total signal transducer and activator of transcription 3.Simultaneously，polyphyllin I decreased the proportion of CD44⁺/CD24^-/low cells.No significant changes were observed in key proteins of the intrinsic apoptosis pathway. Conclusions Polyphyllin I reshapes the hybrid EMT state in MCF-7 spheroids，which is accompanied by the disruption of their high stemness equilibrium.This compound may reduce cellular stemness through the EMT remodeling process，thereby exerting antitumor effects，and this mechanism is independent of the intrinsic apoptosis pathway.</p>","PeriodicalId":6919,"journal":{"name":"中国医学科学院学报","volume":"48 4","pages":"631-639"},"PeriodicalIF":0.0,"publicationDate":"2026-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148838775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}