中国医学科学院学报最新文献

{"title":"Expression Level of Small Nuclear Ribonucleoprotein D1 in Gastric Cancer and Its Effect on Prognosis.","authors":"Yin Li-Xia, Yang Jing-Jing, Niu Min-Zhu, Geng Zhi-Jun, L I Jiang-Yan, L I Jing","doi":"10.3881/j.issn.1000-503X.16097","DOIUrl":"https://doi.org/10.3881/j.issn.1000-503X.16097","url":null,"abstract":"<p><p>Objective To investigate the expression of small nuclear ribonucleoprotein D1 (SNRPD1) in the gastric cancer tissue and evaluate the predictive value of SNRPD1 expression level for the long-term prognosis of gastric cancer patients and the possible functioning mechanism of SNRPD1. Methods The UALCAN and Gene Expression Profiling Interactive Analysis (GEPIA) were employed to analyze the expression level of SNRPD1 in pan-cancer and its relationship with the prognosis of gastric cancer.The clinical data of 109 patients who underwent radical surgery for gastric cancer from January 2014 to January 2017 in the First Affiliated Hospital of Bengbu Medical University were retrospectively analyzed.Gastric cancer and paracancerous tissue samples were collected,and the expression of SNRPD1 was detected by immunohistochemical staining.Lentiviral transfection was employed to construct the BGC-823 gastric cancer cell models with stable high and low expression of SNRPD1,respectively.The CCK-8 assay and colony formation assay were employed to measure the proliferation of gastric cancer cells,and flow cytometry was used to analyze the cell cycle.Western blotting was employed to determine the expression levels of proteins in the signaling pathway. Results The data from UALCAN and GEPIA showed that SNRPD1 was highly expressed in the tissue of malignant tumors including gastric cancer (<i>P</i><0.001).The expression level of SNRPD1 in the gastric cancer tissue was higher than that in the paracancerous tissue (<i>P</i><0.001).Moreover,the expression level of SNRPD1 was positively correlated with the levels of carcinoembryonic antigen (<i>P</i><0.001),carbohydrate antigen 19-9 (<i>P</i><0.001),G stage (<i>P</i>=0.042),T stage (<i>P</i>=0.002),and N stage (<i>P</i>=0.027) in the patients with gastric cancer.The high expression of SNRPD1 had a predictive value for the long-term prognosis of gastric cancer (<i>P</i><0.001),and it was an independent risk factor for the death of gastric cancer patients (<i>P</i>=0.003).The results of gene ontology and kyoto encyclopedia of genes and Genomes enrichment analyses showed that SNRPD1 was involved in the regulation of the cell cycle.The results of CCK-8 and colony formation assays showed that up-regulation of SNRPD1 promoted the proliferation of gastric cancer cells (<i>P</i><0.001,<i>P</i><0.001).The up-regulation of SNRPD1 up-regulated the expression of cyclin-dependent kinase 6 and G<sub>1</sub>/S-specific cyclin-D1 (<i>P</i><0.001,<i>P</i>=0.002),whereas the interference in SNRPD1 led to opposite results (<i>P</i>=0.004,<i>P</i><0.001).SNRPD1 accelerated the G<sub>1</sub>/S phase transition of gastric cancer cells (<i>P</i><0.001).The overexpression of SNRPD1 promoted the expression of phosphorylated phosphatidylinositol 3-kinase (PI3K) and phosphorylated protein kinase B (Akt) in gastric cancer cells (<i>P</i>=0.043,<i>P</i><0.001),whereas disruption of SNRPD1 inhibited their expression (both <i>P</i><0.001).Insulin-li","PeriodicalId":6919,"journal":{"name":"中国医学科学院学报","volume":"47 1","pages":"1-9"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143622973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endobronchial Metastasis From Rectal Cancer Treated by High-Frequency Electrocautery Ablation via Bronchoscope and Targeted Drugs:Report of One Case.","authors":"Yuan Jian-Hua, Xie Zong-Zhou, Y U Wei-Ling, Cui Rong-Hua, L I Jian-Wang","doi":"10.3881/j.issn.1000-503X.16075","DOIUrl":"https://doi.org/10.3881/j.issn.1000-503X.16075","url":null,"abstract":"<p><p>The lungs are the most common sites of metastases from non-pulmonarymalignancies. Endobronchial metastases are rare and have no specificity in clinical manifestations,thus being prone to misdiagnosis and delayed treatment.The common tumors associated with endobronchial metastasis are renal,breast,and colorectal cancers.This article reported one case of postoperative rectal cancer with endobronchial and lung metastases,which was relieved by high-frequency electrocautery ablation <i>via</i> bronchoscope,chemotherapy,and targeted drugs,aiming to provide a reference for clinical diagnosis and treatment.</p>","PeriodicalId":6919,"journal":{"name":"中国医学科学院学报","volume":"47 1","pages":"142-145"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143622952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive Value of Abdominal CT Images Combined With Serological Indicators for Ureteral Involvement in Idiopathic Retroperitoneal Fibrosis.","authors":"Wang Ting-Ting, Jiang Chao, L I Ning, Sun Lu-Lu, Tian Lu-Feng, W U Zhe","doi":"10.3881/j.issn.1000-503X.16050","DOIUrl":"https://doi.org/10.3881/j.issn.1000-503X.16050","url":null,"abstract":"<p><p>Objective To analyze the value of abdominal CT images combined with serological indicators in predicting the ureteral involvement in idiopathic retroperitoneal fibrosis(IRF). Methods The CT images of 79 IRF patients were analyzed retrospectively,including the involved sites and enhancement characteristics of the lesions.According to the inclusion and exclusion criteria,43 patients with complete serological data were selected and assigned into a ureteral involvement group(<i>n</i>=29)and a non-ureteral involvement group(<i>n</i>=14) according to whether ureters were involved in IRF.Logistic regression analysis was performed to select independent risk factors for ureteral involvement in IRF.The receiver operating characteristic(ROC)curve was plotted to evaluate the predictive value of the CT arterial phase enhancement magnitude and serum cystatin C(CysC)for ureteral involvement in IRF. Results The CT images of IRF usually showed a soft tissue density lesion encompassing the abdominal aorta,iliac arteries,ureters,and retroperitoneal tissue,with a wide range of distribution.The ureteral involvement group and the non-ureteral involvement group showed differences in gender(<i>P</i>=0.031),CT arterial phase enhancement amplitude(<i>P</i>=0.014),CT venous phase enhancement amplitude(<i>P</i>=0.032),and serum CysC(<i>P</i>=0.036).Logistic regression analysis showed that gender(<i>P</i>=0.034),CT arterial phase enhancement amplitude(<i>P</i>=0.046),and serum CysC(<i>P</i>=0.041)were independent risk factors for ureteral involvement in IRF.The area under the curve for CT arterial phase enhancement combined with serum CysC to predict ureteral involvement in IRF was 0.776.Ten patients had lower levels of erythrocyte sedimentation rate(<i>P</i><0.001),C-reactive protein(<i>P</i>=0.021),and IgG4(<i>P</i><0.001)in the follow-up period than before treatment. Conclusion The combination of abdominal CT images with serological indicators demonstrates high accuracy in predicting the ureteral involvement in IRF,providing reference for early clinical diagnosis.</p>","PeriodicalId":6919,"journal":{"name":"中国医学科学院学报","volume":"47 1","pages":"48-54"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143623081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Willingness of General Practitioners to Enhance Working Competence in Community Healthcare Centers in Shanghai.","authors":"Zhao Miao-Miao, Chi Yu-Feng, Zhou Chuan-Qiang, Wang Xin-Yue, L I Ning","doi":"10.3881/j.issn.1000-503X.16153","DOIUrl":"https://doi.org/10.3881/j.issn.1000-503X.16153","url":null,"abstract":"<p><p>Objective To understand the willingness of general practitioner(GP) to enhance working competence in community healthcare centers in Shanghai and provide a basis for the competence training of GPs in community healthcare centers. Methods In August 2023,GPs were selected from some community healthcare centers in Shanghai and their willingness to enhance working competence were studied by a questionnaire survey.The survey included 39 secondary indicators in three dimensions:general practice theory,skills,and humanity. Results A total of 1 192 GPs completed the questionnaire,with an effective rate of 100%.The total score of GPs' willingness to enhance their working competence was 258.45±80.93,and the mean score of the three dimensions was 6.63±2.08.The score for the general practice theory was the highest (6.92±1.95),while that for general practice humanity was the lowest (6.44±2.34) among the three dimensions.The score of willingness to enhance working efficiency differed across different age ranges (<i>P</i><0.001),professional titles (<i>P</i><0.001),years of work (<i>P</i><0.001),and educational backgrounds of GPs (<i>P</i>=0.039).Those with the age younger than 30 years old,junior professional titles,less than 5 years of work experience,and a college degree or below had the highest willingness score to enhance their working competence.Among the top three secondary indicators of willingness score in each dimension,the top three methods of working competence enhancement were community general practice and specialized healthcare services combined with outpatient learning,flexible further training,and continuing education courses.Conclusions There is an urgent need for young GPs in community healthcare centers in Shanghai to enhance their working competence.Targeted enhancement plans can be provided to different groups of GPs with different characteristics through community general practice and specialized healthcare services combined with outpatient learning,flexible further training,and continuing education courses,which can further enhance the ability and quality of the GP team.</p>","PeriodicalId":6919,"journal":{"name":"中国医学科学院学报","volume":"47 1","pages":"55-62"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143623097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Sakuranetin on Microglia-Mediated Neuroinflammation After Spinal Cord Injury.","authors":"Lin-Yu Xiao, Yue Chen, Ting Duan, Yang Sun, Yi-Bo Xu, Ya-Jing Zhao, Xue Song, Xing-Zhou Yan, Jian-Guo Hu","doi":"10.3881/j.issn.1000-503X.16087","DOIUrl":"10.3881/j.issn.1000-503X.16087","url":null,"abstract":"<p><p>Objective To investigate the effects of sakuranetin (SK) on motor functions in the mouse model of spinal cord injury (SCI) and decipher the mechanism. Methods Fifty-four C57BL/6J mice were randomized into sham,SCI,and SK groups.The mice in the sham group underwent only laminectomy at T9,while those in the SCI and SK groups were subjected to spinal cord contusion injury at T9.Behavioral tests were conducted at different time points after surgery to evaluate the motor functions of mice in each group.The pathological changes in the tissue were observed to assess the extent of SCI in each group.The role and mechanism of SK in SCI were predicted by gene ontology (GO) and Kyoto encyclopedia of genes and genomes (KEGG) enrichment analyses.Reverse transcription real-time fluorescence quantitative PCR,ELISA,and immunofluorescence were employed to evaluate the inflammation and activation of microglia in SCI mice.BV2 cells <i>in vitro</i> were classified into control (Con),lipopolysaccharide (LPS),and LPS+SK groups.The effects of SK intervention on the release of inflammatory cytokines and the activation of BV2 cells were evaluated.Furthermore,the phosphatidylinositol-3-kinase(PI3K)/protein kinase B (AKT) signaling pathway activator insulin-like growth factor-1 (IGF-1) was used to treat the SK-induced BV2 cells <i>in vitro</i> (SK+IGF-1 group),and SK was used to treat the IGF-1-induced BV2 cells <i>in vitro</i> (IGF-1+SK group).Western blotting was conducted for molecular mechanism validation. Results Behavioral tests and histological staining results showed that compared with the SCI group,the SK group exhibited improved motor abilities and reduced area of damage in the spinal cord tissue (all <i>P</i><0.001).The GO enrichment analysis predicted that SK may be involved in the inflammation following SCI.The KEGG enrichment analysis predicted that SK regulated the PI3K/Akt pathway to exert the neuroprotective effect.The results from <i>in vitro</i> and <i>in vivo</i> experiments showed that SK lowered the levels of tumor necrosis factor-α,interleukin-6,and interleukin-1β and inhibited the activation of microglia (all <i>P</i><0.05).The results of Western blotting showed that SK down-regulated the phosphorylation levels of PI3K and Akt (all <i>P</i><0.001) and inhibited the IGF-1-induced elevation of PI3K and Akt phosphorylation levels (all <i>P</i><0.001).Conversely,IGF-1 had the opposite effects (<i>P</i>=0.001,<i>P</i><0.001).The results of reverse transcription real-time fluorescence quantitative PCR,ELISA,and immunofluorescence showed that the SK+IGF-1 group had higher levels of inflammatory cytokines and more activated microglia than the SK group(all <i>P</i><0.05). Conclusion SK may suppress the activation of the PI3K/Akt pathway to inhibit the inflammation mediated by SCI-induced activation of microglia,ameliorate the pathological damage of the spinal cord tissue,and promote the recovery of motor functions in SCI mice.</p>","PeriodicalId":6919,"journal":{"name":"中国医学科学院学报","volume":" ","pages":"836-848"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142103277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research Progress in Blastic Plasmacytoid Dendritic Cell Neoplasm.","authors":"Fu-Yi Luo, Yan Li","doi":"10.3881/j.issn.1000-503X.15946","DOIUrl":"https://doi.org/10.3881/j.issn.1000-503X.15946","url":null,"abstract":"<p><p>Blastic plasmacytoid dendritic cell neoplasm(BPDCN)is an extremely rare invasive tumor with poor prognosis.The common clinical manifestations of BPDCN include skin injury,bone marrow involvement,and tumor cell spread.BPDCN is often misdiagnosed as other diseases and its diagnosis often requires a combination of clinical manifestations,imaging,histology,and immunophenotyping.Among them,immunophenotyping is crucial for the diagnosis of BPDCN.Although BPDCN is rare and no consensus has been reached on first-line treatment option,new drugs and options for treating this disease have emerged with the development of new drugs and increased awareness of BPDCN.This article reviews the research background,the origin of blastic plasmacytoid dendritic cells,and the recent research progress in the pathogenesis,diagnosis and differential diagnosis,treatment,and prognosis of BPDCN.</p>","PeriodicalId":6919,"journal":{"name":"中国医学科学院学报","volume":"46 6","pages":"949-957"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142942378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Knee Flexor and Extensor Strength on Subjective Function and Motor Performance of Knees After Anterior Cruciate Ligament Reconstruction.","authors":"Ming-Ze Liu, Xiao-Han Zhang, Lei Li, Jing-Yi Sun, Yi Qian, Chen He, Sen Guo, Hao Xu, Ya-Wei Gong, Zhuang Liu, Xiang-Yi Wang, Feng Gao, Jing-Bin Zhou","doi":"10.3881/j.issn.1000-503X.16110","DOIUrl":"https://doi.org/10.3881/j.issn.1000-503X.16110","url":null,"abstract":"<p><p>Objective To evaluate the effects of knee flexor and extensor strength on the subjective function and motor performance of knees after anterior cruciate ligament reconstruction. Methods A total of 53 patients who underwent anterior cruciate ligament reconstruction in the National Institute of Sports Medicine,General Administration of Sport of China from June 2015 to June 2021 and met the inclusion criteria were enrolled in this study.The patients were followed up time for at least 2 years.An isometric muscle strength test system was used to measure the strength of bilateral quadriceps and hamstring muscles.The patients were grouped according to whether the limb symmetry index (LSI) of peak torque of quadriceps and hamstring muscle reached 85% at an angular velocity of 60°/s.Specifically,26 patients were classified into group A (LSI≥85%) and 27 patients were classified into group B (LSI<85%).The subjective function and motor performance of knees were compared between the two groups. Results In terms of subjective function of knees,the international knee documentation committee (IKDC) score (88.76±9.93 <i>vs.</i> 81.08±12.57,<i>P</i>=0.017) and knee injury and osteoarthritis outcome score (KOOS) (86.27±8.96 <i>vs.</i> 80.22±11.31,<i>P</i>=0.036) were different between groups A and B.There was no significant difference in Lysholm score [95.0 (79.8,100.00) <i>vs.</i> 86.00 (66.00,100.00),<i>P</i>=0.238],ACL return to sports after injury scale score (66.08±22.25 <i>vs.</i> 61.12±23.53,<i>P</i>=0.434),Marx score [6.00 (4.75,7.00) <i>vs.</i> 6.00 (4.00,7.00),<i>P</i>=0.805] or Tegner activity score [8.00 (4.00,12.00) <i>vs.</i> 4.00 (2.00,12.00),<i>P</i>=0.566] between the two groups.In terms of motor performance,the single-leg triple hop LSI (0.92±0.13 <i>vs.</i> 0.81±0.18,<i>P</i>=0.016) and single-leg crossover hop LSI (0.96±0.12 <i>vs.</i> 0.84±0.22,<i>P</i>=0.021) showed significant differences between groups A and B,while there was no significant difference in single-leg hop LSI (0.90±0.18 <i>vs.</i> 0.79±0.25,<i>P</i>=0.116) between the two groups.In addition,there was no statistical significance in proprioception [30°:8.83±4.66 <i>vs.</i> 10.73±4.63,<i>P</i>=0.143;45°:6.94±3.82 <i>vs.</i> 7.66±3.93,<i>P</i>=0.504;60°:4.10 (3.20,4.72) <i>vs.</i> 3.90 (2.30,5.20),<i>P</i>=0.493] or Y-balance test results [anterior LSI:0.98 (0.84,1.02) <i>vs.</i> 0.94 (0.86,0.98),<i>P</i>=0.328;posterolateral LSI:1.00±0.08 <i>vs.</i> 0.97±0.07,<i>P</i>=0.249;posteromedial LSI:1.00 (0.97,1.03) <i>vs.</i> 0.96 (0.93,1.03),<i>P</i>=0.179] between groups A and B. Conclusion The patients with good symmetry of quadriceps and hamstring muscle strength after anterior cruciate ligament reconstruction had better subjective function and movement performance of knees than the patients with poor symmetry,which was mainly reflected in the IKDC score,KOOS,single-leg triple hop,and single-leg crossover hop.</p>","PeriodicalId":6919,"journal":{"name":"中国医学科学院学报","volume":"46 6","pages":"805-813"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142942435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knowledge Mapping of Osteoimmunology:A Bibliometric Study.","authors":"Ming-Zhou Chen, Sheng-Tao Wang, Dong-Xu Chen, Wei Peng, Zhao-Xu Li","doi":"10.3881/j.issn.1000-503X.16011","DOIUrl":"10.3881/j.issn.1000-503X.16011","url":null,"abstract":"<p><p>Objective To understand the research status of osteoimmunology by a bibliometric study and provide reference for potential research hotspots in the future. Methods The articles and reviews related to osteoimmunology were retrieved from the Web of Science Core Collection with the time interval from 2002 to 2022.VOSviewer,CiteSpace,and the Bibliometrix package in R were used to analyze the contributions and co-citation relationships of countries/regions,institutions,journals,authors,references,and keywords,and identify research hotspots. Results A total of 812 English-language articles published between 2002 and 2022 were collected,and the annual number of articles was increasing year by year.China had the most articles (<i>n</i>=233,28.69%),followed by the United States and Japan.Sichuan University had the highest number of articles (<i>n</i>=35,4.27%).Takayanagi H ranked first among both publishing authors and co-cited authors.<i>Froniters in Immunology</i> was the journal publishing the highest number of articles (<i>n</i>=45,impact factor of 7.3 in 2023) in this field.The clustering of key nodes and identification of keywords in co-cited references indicated that the research of osteoimmunology mainly focused on signal transduction mechanisms of bone immunity,bone immunity-mediated diseases,and drug treatment.In recent years,the research hotspots of osteoimmunology included macrophage polarization,bone biomaterials,bone regeneration,and therapy. Conclusion This study employed bibliometric methods to comprehensively analyze the countries,institutions,authors,keywords,and references of articles in osteoimmunology,providing guidance and reference for researchers engaged in this field.</p>","PeriodicalId":6919,"journal":{"name":"中国医学科学院学报","volume":"46 6","pages":"899-908"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142942437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Progress in Prevention and Treatment of Dysplasia in Ulcerative Colitis Based on Cyclooxygenase-2/p53 Axis.","authors":"Yi-Lin Zhang, Shu-Sen Yang, Yu-Shan Liu, Shu-Guang Yan","doi":"10.3881/j.issn.1000-503X.15911","DOIUrl":"https://doi.org/10.3881/j.issn.1000-503X.15911","url":null,"abstract":"<p><p>Ulcerative colitis(UC)is a chronic inflammatory bowel disease characterized by non-specific,persistent inflammation in the intestines.This chronic inflammation often increases the risk of serious complications such as colorectal cancer.Dysplasia acts as a driver of cancer development and plays a connecting role in the occurrence and development of chronic intestinal inflammation and colorectal cancer.Cell proliferation/apoptosis imbalance is the driving factor for dysplasia development.The abnormal proliferation/apoptosis of intestinal mucosal epithelial cells may be affected by cyclooxygenase-2(COX-2),tumor suppressor gene p53,or both.Therefore,reasonable regulation of COX-2/p53 axis may be a key to achieving intestinal mucosal proliferation/apoptosis balance.This article discusses the effects and mechanism of COX-2 and p53 in regulating the occurrence and development of dysplasia in UC from the proliferation/apoptosis imbalance of intestinal mucosal epithelial cells,aiming to provide a reference for understanding the mechanism of dysplasia in UC and developing targeted therapeutic drugs.</p>","PeriodicalId":6919,"journal":{"name":"中国医学科学院学报","volume":"46 6","pages":"940-948"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142942374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Knee Joint Rotational Stability on Sport Performance After Anterior Cruciate Ligament Reconstruction.","authors":"Jing-Yi Sun, Feng Gao, Yi Qian, Ying-Qi Zhao, Chen He, Sen Guo, Jing-Bin Zhou","doi":"10.3881/j.issn.1000-503X.16141","DOIUrl":"https://doi.org/10.3881/j.issn.1000-503X.16141","url":null,"abstract":"<p><p>Objective To investigate the effects of rotation stability after anterior cruciate ligament reconstruction (ACLR) on subjective outcomes,sport performance,psychological readiness,and return to sport. Methods The patients who underwent ACLR in the Sports Hospital,National Institute of Sports Medicine,General Administration of Sport of China from January 2015 to January 2021 were followed up during the period from November 2022 to December 2023.The patients were grouped according to the results of the pivot shift test (PST) of the affected knee at the last follow-up visit.A total of 66 patients who participated in the follow-up and met the inclusion and exclusion criteria were finally enrolled in this study,including 32 patients showing a negative PST result (stable group) and 34 patients showing a positive PST result (unstable group).The basic information,subjective function score,and return-to-sport performance were compared between the two groups. Results In terms of sport performance,the two groups showed differences in the limb symmetry index in single-leg hops,triple hops,and crossover hops (<i>P</i>=0.028,<i>P</i>=0.024,and <i>P</i>=0.044,respectively).The anterior cruciate ligament-return to sport after injury scale score was higher in the stable group than in the unstable group [(70.44±22.82) scores <i>vs.</i> (53.44±21.74) scores,<i>P</i>=0.003].The mean of KT-2000 test results in the stable group was lower than that in the unstable group [(0.53±1.02) mm <i>vs.</i> (2.06±2.31) mm,<i>P</i>=0.001].The Lysholm score,international knee documentation committee score,knee injury and osteoarthritis outcome score,Tegner score,and Marx score did not have significance between the two groups (all <i>P</i>>0.05).The return-to-sport rate was 43.8% (including 14.3% reaching safe return criteria,which accounted for 6.3% in all the patients) in the stable group and 35.3% (including 8.3% reaching safe return criteria,which accounted for 2.9% in all the patients) in the unstable group.There was no difference in the 60°/s isokinetic muscle strength,maximal muscle strength ratio of the affected extensor-flexor muscles,or Y-balance test result between the two groups (all <i>P</i>>0.05). Conclusions Knee joint rotational instability after ACLR results in poor performance in single-leg hops,triple hops,and crossover hops,low psychological readiness,and anterior-posterior knee laxity.In short- to medium-term follow-up for ACLR,the return-to-sport rate remained low regardless of knee joint rotational stability,with the majority of patients failing to meet safe return criteria.</p>","PeriodicalId":6919,"journal":{"name":"中国医学科学院学报","volume":"46 6","pages":"814-822"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142942427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}