中国医学科学院学报最新文献

{"title":"[Effects of Proteasome 20S Subunit Beta 8 on Proliferation,Migration,and Invasion of Clear Cell Renal Cell Carcinoma Cells <i>via</i> Mitogen-Activated Protein Kinase Kinase/Extracellular Signal-Regulated Kinase Signaling Pathway].","authors":"Yu-Fei Hao, Yu Shi, Jin-Xiu Zheng, Xue-Ting Zhao, Sheng-Lu Liu, Li-Jun Yang","doi":"10.3881/j.issn.1000-503X.16003","DOIUrl":"https://doi.org/10.3881/j.issn.1000-503X.16003","url":null,"abstract":"<p><p>Objective To explore the effects of proteasome 20S subunit beta 8 (PSMB8) on the proliferation,migration,and invasion of clear cell renal cell carcinoma (ccRCC) cells and whether PSMB8 promotes tumor progression by activating the mitogen-activated protein kinase kinase (MEK)/extracellular signal-regulated kinase (ERK) signaling pathway. Methods The Cancer Genome Atlas was employed to analyze the mRNA levels of PSMB8 in ccRCC and normal tissue,and the expression levels of PSMB8 in ccRCC tissue and cells were determined by real-time quantitative PCR,Western blotting,and immunohistochemistry.Furthermore,the cell lines with stable overexpression and knockdown of PSMB8 were constructed.The CCK-8 assay and colony formation assay were employed to examine the cell proliferation,and the wound healing assay and Transwell assay were employed to examine the invasion and migration of cells.Kyoto Encyclopedia of Genes and Genomes pathway enrichment was performed to analyze the co-expressed genes of PSMB8.Western blotting was used to measure the phosphorylation levels of the proteins in the MEK/ERK signaling pathway.Finally,the rescue experiment was carried out with the ERK agonist C16-PAF. Results Compared with the normal tissue,the ccRCC tissue showed up-regulated mRNA and protein levels of PSMB8 (both <i>P</i><0.001),which were associated with the TNM stage of patients with ccRCC (<i>P</i><0.001).Compared with the negative control group,overexpression of PSMB8 promoted the proliferation (<i>P</i>=0.021,<i>P</i>=0.039),migration and invasion (all <i>P</i><0.001) of 786-O and ACHN cells,and the knockdown of PSMB8 inhibited the proliferation (<i>P</i>=0.022,<i>P</i>=0.005),migration and invasion (all <i>P</i><0.001) of 786-O and ACHN cells.The pathway enrichment analysis of co-expressed genes of PSMB8 predicted the mitogen-activated protein kinase signaling pathway (<i>P</i><0.001).After the knockdown of PSMB8,786-O and ACHN cells showed lowered phosphorylation levels of MEK1/2 (<i>P</i>=0.017,<i>P</i>=0.016) and ERK1/2 (<i>P</i>=0.010,<i>P</i>=0.040) and down-regulated transcription levels of ERK downstream factors c-Myc (<i>P</i>=0.043,<i>P</i>=0.038),c-Fos (<i>P</i>=0.025,<i>P</i>=0.008),and CyclinD1 (<i>P</i>=0.006,<i>P</i>=0.047).Compared with the ERK agonist C16-PAF group,the PSMB8 knockdown + C16-PAF group showed inhibited proliferation (<i>P</i>=0.003,<i>P</i>=0.002),migration and invasion (all <i>P</i><0.001) of 786-O and ACHN cells. Conclusion PSMB8 may promote the proliferation,migration,and invasion of ccRCC cells by activating the MEK/ERK signaling pathway.</p>","PeriodicalId":6919,"journal":{"name":"中国医学科学院学报","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142581720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Research Progress in Health Hazards and Daily Intervention of Age-Related Hearing Loss].","authors":"Yu Li, Shi-Han Shao, Shu-Ting Qiu, Jun-Hao Hu, Xiao-Hua Tan, Yu Hong","doi":"10.3881/j.issn.1000-503X.15880","DOIUrl":"https://doi.org/10.3881/j.issn.1000-503X.15880","url":null,"abstract":"<p><p>Age-related hearing loss (ARHL) is a common chronic disease that poses a serious threat to the physical and mental health of the elderly in an aging society.It is a sensorineural hearing loss characterized by the loss of auditory hair cells,stria vascularis lesions,apoptosis of spiral ganglia,and degeneration of the auditory central nervous system,reducing the quality of life of the patients.This article reviews the research progress in the relationship of ARHL with Alzheimer's disease,depression,and frailty,as well as the daily intervention in ARHL.This review aims to improve people's awareness and attention to the health hazards of ARHL and to delay the occurrence and development of ARHL by implementing daily intervention measures to form a healthy lifestyle.</p>","PeriodicalId":6919,"journal":{"name":"中国医学科学院学报","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142581734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Thyroglossal Duct Papillary Carcinoma:Report of One Case and Literature Review].","authors":"Guo-Feng Dai, Shu-Ya Li, Yi-Qiang Yin, Gang-Pu Wang","doi":"10.3881/j.issn.1000-503X.15901","DOIUrl":"https://doi.org/10.3881/j.issn.1000-503X.15901","url":null,"abstract":"<p><p>Thyroglossal duct papillary carcinoma is extremely rare in clinical practice.This article reports a case of a thyroglossal duct cyst complicated by thyroid papillary carcinoma,while also reviewing the relevant literature.It summarizes the clinical manifestations,imaging characteristics,and pathological features of thyroglossal duct papillary carcinoma and discusses the relationship between thyroglossal duct cysts,malignant transformation of thyroglossal duct cysts,and thyroid papillary carcinoma.</p>","PeriodicalId":6919,"journal":{"name":"中国医学科学院学报","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142581755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Chen Zhiqian's Thoughts on Public Health in the 1920s].","authors":"Zhe-Xi Gong, Jin-Heng Li, Pu-An Cui, Meng-Lan Lin, Zhong He","doi":"10.3881/j.issn.1000-503X.16020","DOIUrl":"https://doi.org/10.3881/j.issn.1000-503X.16020","url":null,"abstract":"<p><p>During his studies at the Peking Union Medical College (1921-1929),Chen Zhiqian formed his thoughts on public health under the influences of modern medical education and the advanced thinking of the times,which laid an ideological foundation for his later engagement in rural health care and reflected the medical progress in China at that time.In the 1920s,Chen Zhiqian's thoughts on public health mainly encompassed five aspects.First,health was a cornerstone of the country's wealth and people's well-being.Second,he belived in comprehensive \"big medicine\" which emphasized the combination of prevention and treatment.Third,he advocated the return of medicine to the state and the building of a medical system covering all people.Fourth,he advocated maternal training and institutional standardization,emphasizing child health protection.Fifth,he was committed to the popularization of health science and advocated health education reform.Summarizing the above five aspects is of great significance for enriching and improving the academic evaluation about Chen Zhiqian and provides a reference for today's work on public health.</p>","PeriodicalId":6919,"journal":{"name":"中国医学科学院学报","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142581654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Mechanism of Butylphthalide in Treating Delayed Encephalopathy After Carbon Monoxide Poisoning Based on Activation of Microglia].","authors":"Yu Shi, Bao-Jun Wang, Chao Chen, Jiang-Xia Pang, Yang Li, Jun Zhang, Mao-Mao Xu","doi":"10.3881/j.issn.1000-503X.16017","DOIUrl":"https://doi.org/10.3881/j.issn.1000-503X.16017","url":null,"abstract":"<p><p>Objective To explore the mechanism of butylphthalide (NBP) in regulating microglia activation and inflammatory cytokine expression in the hippocampus of the mouse model of delayed encephalopathy after carbon monoxide poisoning (DEACMP). Methods Wild-type C57 adult mice with normal cognitive function were selected,and DEACMP was modeled by static inhalation of carbon monoxide.The mice were randomized into three groups:DEACMP,control,and NBP.The NBP group was administrated with NBP suspension at 6 mg/kg by gavage for 21 days,and the DEACMP and control groups were administrated with the same amount of vegetable oil by gavage.The hippocampal injury was observed by HE staining.The protein level of ionized calcium-binding adapter molecule 1 (IBA1) was determined by Western blotting,and the levels of downstream inflammatory cytokines were measured by ELISA. Results Compared with the control group,the DEACMP and NBP groups showed prolonged escape latency (<i>P</i>=0.001,<i>P</i>=0.029),reduced nerve cells (<i>P</i>=0.001,<i>P</i>=0.035),up-regulated expression of IBA1 (<i>P</i>=0.001,<i>P</i>=0.042),increased mean fluorescence intensity of IBA1 (<i>P</i>=0.001,<i>P</i>=0.021),and elevated levels of tumor necrosis factor-α (TNF-α) (<i>P</i>=0.002,<i>P</i>=0.024),interleukin (IL)-6 (<i>P</i>=0.001,<i>P</i>=0.015),and IL-1β (<i>P</i>=0.001,<i>P</i>=0.023).Compared with the DEACMP group,the NBP group showed shortened escape latency (<i>P</i>=0.025),increased nerve cells (<i>P</i>=0.039),down-regulated expression of IBA1 (<i>P</i>=0.035),decreased average fluorescence intensity of IBA1 (<i>P</i>=0.031),and lowered levels of TNF-α (<i>P</i>=0.028),IL-6 (<i>P</i>=0.037),and IL-1β (<i>P</i>=0.034). Conclusion NBP can inhibit the activation of microglia and reduce the expression of inflammatory factors,thereby alleviating cognitive dysfunction and brain tissue damage caused by DEACMP.</p>","PeriodicalId":6919,"journal":{"name":"中国医学科学院学报","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142581727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Effect of Sakuranetin on Microglia-Mediated Neuroinflammation After Spinal Cord Injury].","authors":"Lin-Yu Xiao, Yue Chen, Ting Duan, Yang Sun, Yi-Bo Xu, Ya-Jing Zhao, Xue Song, Xing-Zhou Yan, Jian-Guo Hu","doi":"10.3881/j.issn.1000-503X.16087","DOIUrl":"https://doi.org/10.3881/j.issn.1000-503X.16087","url":null,"abstract":"<p><p>Objective To investigate the effects of sakuranetin (SK) on motor functions in the mouse model of spinal cord injury (SCI) and decipher the mechanism.Methods Fifty-four C57BL/6J mice were randomized into sham,SCI,and SK groups.The mice in the sham group underwent only laminectomy at T9,while those in the SCI and SK groups were subjected to spinal cord contusion injury at T9.Behavioral tests were conducted at different time points after surgery to evaluate the motor functions of mice in each group.The pathological changes in the tissue were observed to assess the extent of SCI in each group.The role and mechanism of SK in SCI were predicted by gene ontology (GO) and Kyoto encyclopedia of genes and genomes (KEGG) enrichment analyses.Reverse transcription real-time fluorescence quantitative PCR,ELISA,and immunofluorescence were employed to evaluate the inflammation and activation of microglia in SCI mice.BV2 cells in vitro were classified into control (Con),lipopolysaccharide (LPS),and LPS+SK groups.The effects of SK intervention on the release of inflammatory cytokines and the activation of BV2 cells were evaluated.Furthermore,the phosphatidylinositol-3-kinase(PI3K)/protein kinase B (AKT) signaling pathway activator insulin-like growth factor-1 (IGF-1) was used to treat the SK-induced BV2 cells in vitro (SK+IGF-1 group),and SK was used to treat the IGF-1-induced BV2 cells in vitro (IGF-1+SK group).Western blotting was conducted for molecular mechanism validation.Results Behavioral tests and histological staining results showed that compared with the SCI group,the SK group exhibited improved motor abilities and reduced area of damage in the spinal cord tissue (all P<0.001).The GO enrichment analysis predicted that SK may be involved in the inflammation following SCI.The KEGG enrichment analysis predicted that SK regulated the PI3K/Akt pathway to exert the neuroprotective effect.The results from in vitro and in vivo experiments showed that SK lowered the levels of tumor necrosis factor-α,interleukin-6,and interleukin-1β and inhibited the activation of microglia (all P<0.05).The results of Western blotting showed that SK down-regulated the phosphorylation levels of PI3K and Akt (all P<0.001) and inhibited the IGF-1-induced elevation of PI3K and Akt phosphorylation levels (all P<0.001).Conversely,IGF-1 had the opposite effects (P=0.001,P<0.001).The results of reverse transcription real-time fluorescence quantitative PCR,ELISA,and immunofluorescence showed that the SK+IGF-1 group had higher levels of inflammatory cytokines and more activated microglia than the SK group(all P<0.05).Conclusion SK may suppress the activation of the PI3K/Akt pathway to inhibit the inflammation mediated by SCI-induced activation of microglia,ameliorate the pathological damage of the spinal cord tissue,and promote the recovery of motor functions in SCI mice.</p>","PeriodicalId":6919,"journal":{"name":"中国医学科学院学报","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142103277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Effects of Total Intravenous Anesthesia on Circadian Rhythms in Patients Undergoing Cardiac Transcatheter Closure].","authors":"Yun-Fei Gu, Zhen-Xing Bao, Kai-Hua Yu, Ling Wang, Dian-Wei Cheng, Su-Heng Chen, Yu-Lan Li","doi":"10.3881/j.issn.1000-503X.15896","DOIUrl":"10.3881/j.issn.1000-503X.15896","url":null,"abstract":"<p><p>Objective To evaluate the effects of total intravenous anesthesia on the circadian rhythms in the patients undergoing cardiac transcatheter closure. Methods Thirty patients undergoing cardiac transcatheter closure under elective intravenous anesthesia were included in this study.Paired <i>t</i>-tests were performed to compare the mRNA levels of the genes encoding circadian locomotor output cycles kaput(CLOCK),brain and muscle ARNT-1 like protein-1(BMAL1),cryptochrome 1(CRY1),and period circadian clock 2(PER2),the Munich Chronotype Questionnaire(MCTQ)score,and the Pittsburgh Sleep Quality Index(PSQI)score before and after anesthesia.Multiple stepwise regression analysis was performed to screen the factors influencing sleep chronotype and PSQI total score one week after surgery. Results The postoperative mRNA level of CLOCK was higher [1.38±1.23 <i>vs</i>.1.90±1.47;<i>MD</i>(95%<i>CI</i>):0.52(0.20-0.84),<i>t</i>=3.327,<i>P</i>=0.002] and the postoperative mRNA levels of CRY1 [1.56±1.50 <i>vs</i>.1.13±0.98;<i>MD</i>(95%<i>CI</i>):-0.43(-0.81--0.05),<i>t</i>=-2.319,<i>P</i>=0.028] and PER2 [0.82±0.63 <i>vs</i>.0.50±0.31;<i>MD</i>(95%<i>CI</i>):-0.33(-0.53--0.12),<i>t</i>=-3.202,<i>P</i>=0.003] were lower than the preoperative levels.One week after surgery,the patients presented advanced sleep chronotype [3:03±0:59 <i>vs</i>.2:42±0:37;<i>MD</i>(95%<i>CI</i>):-21(-40--1),<i>t</i>=-2.172,<i>P</i>=0.038],shortened sleep latency [(67±64)min <i>vs</i>.(37±21)min;<i>MD</i>(95%<i>CI</i>):-30.33(-55.28--5.39),<i>t</i>=-2.487,<i>P</i>=0.019],lengthened sleep duration [(436±83)min <i>vs</i>.(499±83)min;<i>MD</i>(95%<i>CI</i>):62.80(26.93-98.67),<i>t</i>=3.581,<i>P</i>=0.001],increased sleep efficiency [(87.59±10.35)% <i>vs</i>.(92.98±4.27)%;<i>MD</i>(95%<i>CI</i>):5.39(1.21-9.58),<i>t</i>=2.636,<i>P</i>=0.013],decreased sleep quality score [1.13±0.78 <i>vs</i>.0.80±0.71;<i>MD</i>(95%<i>CI</i>):-0.33(-0.62--0.05),<i>t</i>=-2.408,<i>P</i>=0.023],and declined PSQI total score [6.60±3.17 <i>vs</i>.4.03±2.58;<i>MD</i>(95%<i>CI</i>):-2.57(-3.87--1.27),<i>t</i>=-4.039,<i>P</i><0.001].Body mass index(BMI)(<i>B</i>=-227.460,<i>SE</i>=95.475,<i>t</i>=-2.382,<i>P</i>=0.025),anesthesia duration(<i>B</i>=-47.079,<i>SE</i>=18.506,<i>t</i>=-2.544,<i>P</i>=0.017),and mRNA level of PER2(<i>B</i>=2815.804,<i>SE</i>=1080.183,<i>t</i>=2.607,<i>P</i>=0.015)collectively influenced the sleep chronotype,and the amount of anesthesia medicine(<i>B</i>=0.067,<i>SE</i>=0.028,<i>t</i>=2.385,<i>P</i>=0.024)independently influenced the PSQI one week after surgery. Conclusion Total intravenous anesthesia can improve sleep habits by advancing sleep chronotype.BMI,anesthesia duration,and mRNA level of PER2 collectively influence sleep chronotype one week after surgery.The amount of anesthesia medicine independently influences the PSQI total score one week after surgery.</p>","PeriodicalId":6919,"journal":{"name":"中国医学科学院学报","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140874419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Effects of Schisandrae Chinensis Fructus Lignans on Alertness of Rats With Sleep Deprived by Treadmill Exercise].","authors":"Ya-Nan Wu, Qing Ma, Yan-Yan Wang, Li-Li Huang","doi":"10.3881/j.issn.1000-503X.15910","DOIUrl":"https://doi.org/10.3881/j.issn.1000-503X.15910","url":null,"abstract":"<p><p>Objective To investigate the effects of Schisandrae Chinensis Fructus lignans on the alertness of the rats with sleep deprived by treadmill exercise and the underlying neurobiological mechanism. Methods According to the random number table method,SD male rats were assigned into control,sleep deprivation,low-,medium-,and high-dose Schisandrae Chinensis Fructus lignans,and atomoxetine hydrochloride groups,with 8 rats in each group.The rats in other groups except the control group were subjected to sleep deprivation by treadmill exercise for 3 d.During the deprivation period,each administration group was administrated with the corresponding drug by gavage,and a 5-9 hole tester was used to test the alertness performance of rats in each group. Furthermore,other SD male rats were selected and randomized into control,sleep deprivation,Schisandrae Chinensis Fructus lignans (67.2 mg/kg) and atomoxetine hydrochloride groups,with 10 rats in each group.The rats were modeled with the sleep deprivation method the same as that above and administrated with corresponding agents.ELISA was employed to measure the serum level of orexin A in each group of rats.The protein levels of c-Fos,orexin receptor 1,and orexin receptor 2 in the prefrontal cortex of rats in each group were observed by immunofluorescence and Western blotting. Results Compared with the control group,sleep deprivation reduced the choice accuracy (<i>P</i><0.001) and increased the omission responses,omission percent,and mean correct response latency (<i>P</i>=0.002,<i>P</i>=0.003,<i>P</i>=0.020).Compared with the sleep deprivation group,medium- and high-dose Schisandrae Chinensis Fructus lignans and atomoxetine hydrochloride improved the alertness of rats,as demonstrated by the increased choice accuracy (<i>P</i>=0.001,<i>P</i>=0.006,<i>P</i><0.001) and reduced omission responses (<i>P</i>=0.001,<i>P</i>=0.001,<i>P</i><0.001),omission percent (<i>P</i>=0.001,<i>P</i>=0.002,<i>P</i><0.001),and mean correct response latency (<i>P</i>=0.018,<i>P</i>=0.003,<i>P</i>=0.014).Compared with the control group,the sleep deprivation group showed elevated level of orexin A in the serum (<i>P</i><0.001),up-regulated expression of c-Fos (<i>P</i><0.001),and down-regulated expression of orexin receptor 1 (<i>P</i>=0.037) in the prefrontal cortex.Compared with the sleep deprivation group,Schisandrae Chinensis Fructus lignans (67.2 mg/kg) and atomoxetine hydrochloride lowered the orexin A level in the serum (<i>P</i>=0.005,<i>P</i>=0.029),down-regulated the expression of c-Fos (<i>P</i>=0.028,<i>P</i>=0.036),and up-regulated the expression of orexin receptor 1 (<i>P</i>=0.043,<i>P</i>=0.013) in the prefrontal cortex. Conclusion Schisandrae Chinensis Fructus lignans may antagonize the alertness decrease caused by sleep deprivation by regulating the secretion of orexin and the expression of orexin receptor 1 in the prefrontal cortex.</p>","PeriodicalId":6919,"journal":{"name":"中国医学科学院学报","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142118655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Research Progress of Ferroptosis in Ulcerative Colitis].","authors":"Qin Chen, Li-Fan Peng, Rui Xu, Long Lou, Zi-Yun Peng","doi":"10.3881/j.issn.1000-503X.15918","DOIUrl":"https://doi.org/10.3881/j.issn.1000-503X.15918","url":null,"abstract":"<p><p>Ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized by continuous inflammation and ulcer formation in the intestinal mucosa.Its pathogenesis involves immune dysfunction,dysbiosis of gut microbiota,and mucosal damage caused by inflammation.Ferroptosis is an iron-dependent form of cell death regulated by disturbances in iron metabolism,lipid peroxidation,and depletion of glutathione (GSH).Studies have indicated that ferroptosis plays a crucial role in the pathogenesis of UC,particularly in regulating inflammatory responses and damaging intestinal epithelial cells.This article reviews the regulatory mechanisms and roles of ferroptosis in UC and discusses the potential therapeutic strategies to alleviate UC symptoms by modulating iron metabolism,reducing lipid peroxidation,and maintaining GSH levels,providing new targets and directions for the diagnosis and treatment of UC.</p>","PeriodicalId":6919,"journal":{"name":"中国医学科学院学报","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142118661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Single Center Experience in Surgical Treatment of Extracranial Supra-Aortic Aneurysms].","authors":"Gen-Huan Yang, Peng-Zhi Liao, Xin-Nong Liu, Yan Wang, Yu-Long Jia, Chen-Yang Shen","doi":"10.3881/j.issn.1000-503X.16082","DOIUrl":"10.3881/j.issn.1000-503X.16082","url":null,"abstract":"<p><p>Objective To evaluate the effect of surgical treatment on extracranial supra-aortic aneurysms and summarize the experience. Methods The clinical data of 10 patients undergoing surgical treatment of extracranial supra-aortic aneurysms from May 2019 to November 2023 in the Department of Vascular Surgery of Beijing Tiantan Hospital affiliated to Capital Medical University were collected.The 10 patients included 5 patients with internal carotid artery aneurysm,2 patients with subclavian artery aneurysm,2 patients with vertebral artery aneurysm,and 1 patient with internal carotid artery aneurysm combined with ipsilateral subclavian artery aneurysm.The surgical indications,surgical regimens,clinical efficacy,and complications were retrospectively analyzed. Results All the 10 patients underwent surgery successfully,with the surgery duration range of 60-420 min and the median surgery duration of 180.0 (121.5,307.5) min.Intraoperative bleeding volume varied within 30-400 mL,with a median of 90 (50,125) mL.The time of carotid artery blocking and vertebral artery blocking varied within the ranges of 10-20 min and 20-30 min,with the medians of 15.0 (11.5,16.3) min and 25.0 (15.0,22.5) min,respectively.No cardiac accident,cerebral infarction,or cerebral hemorrhage occurred during the perioperative period.The 10 patients were followed up for 3-58 months,with the median follow-up time of 8.5 (5.3,17.0) months.One patient with subclavian artery aneurysm developed artificial vessel occlusion 20 months after surgery.One patient with internal carotid artery aneurysm developed distal carotid artery stenosis 6 months after surgery. Conclusion Surgical treatment should be actively adopted for extracranial supra-aortic aneurysms,and individualized surgical regimens should be designed according to patient conditions.</p>","PeriodicalId":6919,"journal":{"name":"中国医学科学院学报","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141858725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}