中国医学科学院学报最新文献

{"title":"Exploring the Practice of Palliative Medicine Through Lens of Body Philosophy.","authors":"Qing-Qing Mao, Fei Li, Xin-Qing Zhang","doi":"10.3881/j.issn.1000-503X.16911","DOIUrl":"https://doi.org/10.3881/j.issn.1000-503X.16911","url":null,"abstract":"<p><p>Palliative medicine is a newly emerging branch of clinical medicine,with palliative care forming the core of its clinical practice.It is experiencing dynamic progress in China.This paper analyzes the similarities and differences among four definitions of palliative care to reveal the theoretical breakthroughs emerging from its localization process.From the perspective of body philosophy,it elucidates the shift in clinical reasoning from symptom management to holistic care.Palliative care,grounded in the integrity of the human body,implements the holistic care that approaches patients' pain,suffering,social relationships,and meaning making as an integrated system.This paper argues that the body possesses dual ontological status as both a site of medical intervention and an existential medium of intersubjectivity.And the body philosophy provides one of the philosophical foundations for the practice and disciplinary development of palliative medicine.</p>","PeriodicalId":6919,"journal":{"name":"中国医学科学院学报","volume":"48 1","pages":"59-64"},"PeriodicalIF":0.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147508683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spontaneous Spinal Epidural Hematoma:Report of One Case and Literature Review.","authors":"Shi-Rong Li, Bin Su, Qi-Jun Tian, Bo Liu","doi":"10.3881/j.issn.1000-503X.16514","DOIUrl":"10.3881/j.issn.1000-503X.16514","url":null,"abstract":"<p><p>Spontaneous spinal epidural hematoma is a rare nervous system emergency,and its incidence rate is about 1/1 000 000.This paper reports a case of spontaneous spinal epidural hematoma,reviews the related literature,and summarizes and analyzes the clinical manifestations,diagnosis,and treatment of spontaneous spinal epidural hematoma,aiming to improve clinicians' understanding of this rare disease.</p>","PeriodicalId":6919,"journal":{"name":"中国医学科学院学报","volume":"48 1","pages":"198-204"},"PeriodicalIF":0.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147508468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of Palliative Medicine Teaching in the Training of Medical Humanistic Skills for Resident Physicians in the Department of Cardiovascular Medicine.","authors":"Yun-Ting Zhang, Wen-Qiang Yang, Zhen Zhang, Jing Li, Jin-Gang Zheng","doi":"10.3881/j.issn.1000-503X.16761","DOIUrl":"10.3881/j.issn.1000-503X.16761","url":null,"abstract":"<p><p>Objective To evaluate the effect of applying palliative medicine teaching in the training of medical humanistic skills for resident physicians in the department of cardiovascular medicine. Methods A total of 36 resident physicians who received standardized training in the Department of Cardiology,China-Japan Friendship Hospital from June to December 2023 were allocated via the random number table method into two groups(<i>n</i>=18).According to the requirements of standardized training and palliative medicine teaching for resident physicians,the palliative medicine course was modulated and incorporated in the standardized training in the experimental group.The control group was taught in accordance with the requirements of standardized training for resident physicians and medical humanistic contents.After teaching,medical humanistic skills assessment and a self-evaluation questionnaire survey were employed to compare the teaching performance between the two groups. Results In terms of medical humanistic skills assessment:the experimental group scored higher than the control group in empathy,handling family feedback,reaching consensus,and overall score(all <i>P</i><0.05).The self-evaluation questionnaire survey showed that the experimental group had higher levels of interest in medical humanities and clinical communication skills than the control group(both <i>P</i><0.05). Conclusion Palliative medicine teaching can help stimulate the interest of resident physicians in humanistic medicine,improve clinical communication skills,and enhance medical humanistic skills.</p>","PeriodicalId":6919,"journal":{"name":"中国医学科学院学报","volume":" ","pages":"95-100"},"PeriodicalIF":0.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145761921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expert Consensus on Artificial Intelligence Proficiency for Medical Educators(2025 Edition).","authors":"Hui Pan, Meng-Chun Gong, Jing-Hui Lu, Zhi-Rong Zeng, Wei Chen, Hao Wu, Li Luo, Wen-Wen Sun, Hui Liu, Hang Li, Wei Wang, Yan Luo, Bo-Han Zhang, Xun-Ming Ji","doi":"10.3881/j.issn.1000-503X.17190","DOIUrl":"10.3881/j.issn.1000-503X.17190","url":null,"abstract":"<p><p>In response to the challenges posed by the profound integration of generative artificial intelligence(AI)into medical education,this consensus proposes a logically coherent,medically distinctive,forward-looking,and operable AI proficiency framework for medical educators(competency items of medical educators' AI proficiency,CAIP-ME).Through systematic literature review,preliminary framework construction,multiple rounds of expert pre-study,and a structured Delphi method involving extensive consultations with 60 interdisciplinary experts,the core competency items and assessment standards for AI proficiency among medical educators were demonstrated and calibrated.The framework encompasses five core dimensions and 25 specific competency items.The five dimensions are value recognition and ethical foundation,technical understanding and tool application,teaching integration and innovative practice,learning assessment and precise empowerment,and professional development and ecosystem co-construction.Competency items are categorized into 11 foundational competency items essential for all educators and 14 developmental competency items for those pursuing excellence.Each competency item is described in terms of its conceptual definition and key behavioral manifestations,accompanied by observable assessment indicators.This consensus aims to provide a scientific basis for the professional development of medical educators and the faculty building in medical institutions,while establishing a key reference standard for educator competency development in the context of digital transformation in medical education.</p>","PeriodicalId":6919,"journal":{"name":"中国医学科学院学报","volume":" ","pages":"1-12"},"PeriodicalIF":0.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146049857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in Chimeric Antigen Receptor T Cell Therapy in Neuroimmune Diseases.","authors":"Bian-Jun Ma, Fu-Wen Yang, Yan-Hong Wang, Xin Wang","doi":"10.3881/j.issn.1000-503X.16568","DOIUrl":"https://doi.org/10.3881/j.issn.1000-503X.16568","url":null,"abstract":"<p><p>Antibody therapy is a crucial modality for the treatment of neuroimmune diseases.While it can regulate disease activity in the majority of patients,several individuals remain unresponsive to antibody therapy;additionally,the blood-brain barrier restricts the bioavailability and effectiveness of antibodies within the central nervous system.Unlike antibody therapies,emerging chimeric antigen receptor(CAR)-T cell therapies integrate the biological functions of antibodies that target specific molecules with the potent immune capabilities of T cells,resulting in enhanced therapeutic efficacy,improved tissue permeability,and a more pronounced capacity to eliminate target cells.This study encapsulated the advancements in CAR-T cell therapy for neuroimmune illnesses,aiming to furnish novel insights for the enhancement of CAR-T cell therapy to facilitate its practical use.</p>","PeriodicalId":6919,"journal":{"name":"中国医学科学院学报","volume":"48 1","pages":"162-169"},"PeriodicalIF":0.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147508671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular Mechanism and Application Progress of Circular RNA Regulating Ischemic Stroke Through the Competing Endogenous RNA Network.","authors":"Tian-Pei Wang, Li-Li Teng, Min-Min Wu, Wen-Jing Song, Han-Wen Ma, Lu-Wen Zhu","doi":"10.3881/j.issn.1000-503X.16778","DOIUrl":"10.3881/j.issn.1000-503X.16778","url":null,"abstract":"<p><p>Ischemic stroke(IS)remains a predominant contributor to mortality and disability,with current clinical interventions demonstrating suboptimal therapeutic efficacy.Recent studies have shown that circular RNA(circRNA)participates in pathological processes through the competing endogenous RNA(ceRNA)regulatory network,involving key processes such as apoptosis,inflammatory response,angiogenesis,autophagy,oxidative stress,and neuronal regeneration.This study reviews the molecular mechanism and application progress of circRNA regulating IS through the ceRNA network,aiming to provide theoretical support for the in-depth development of circRNA in the diagnosis and treatment strategies of IS and offer guidance for future related research and clinical practice.</p>","PeriodicalId":6919,"journal":{"name":"中国医学科学院学报","volume":" ","pages":"144-152"},"PeriodicalIF":0.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145761923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting Value of Amide Proton Transfer-Weighted Imaging and T2 Mapping for Microsatellite Instability in Endometrial Adenocarcinoma.","authors":"Lian-Hua Cheng, Ling-Yu Chang, De-Xin Yu, Qing Wang, Jin-Zheng Jia, Fang Wang","doi":"10.3881/j.issn.1000-503X.16469","DOIUrl":"10.3881/j.issn.1000-503X.16469","url":null,"abstract":"<p><p>Objective To explore the value of amide proton transfer-weighted imaging(APTw) and T2 mapping in assessing microsatellite instability(MSI) in endometrial adenocarcinoma. Methods The patients with clinically suspected endometrial cancer were prospectively enrolled and underwent APTw and T2 mapping before operation.Two radiologists independently outlined the regions of interest and measured the quantitative parameters.The intragroup correlation coefficients were calculated to assess the agreement of MRI parameters measured by the two radiologists.The independent samples <i>t</i>-test and Mann-Whitney <i>U</i> test were conducted to compare quantitative variables between the MSI and microsatellite stability(MSS) groups.The receiver operator characteristic curve was established to evaluate the prediction performance of different parameters.The DeLong test was implemented to compare the area under the curve(AUC) between single parameters and their combination. Results Twenty-one patients in the MSI group and 37 patients in the MSS group were finally enrolled in this study.The results showed excellent agreement between two radiologists in assessing MRI parameters.The MSI group had higher APTw values[(2.72±0.52)% <i>vs.</i>(2.08±0.39)%,<i>P</i><0.001]and lower T2 values[92.25(90.82,99.91) ms <i>vs.</i>101.80(96.15,112.13) ms,<i>P</i><0.001]than the MSS group.The receiver operating characteristic curve showed that the AUC of APTw and T2 values were 0.821(95%<i>CI</i>=0.698-0.909) and 0.793(95%<i>CI</i>=0.666-0.888),respectively.No significant difference in diagnostic efficacy was observed between the two sequences(<i>P</i>=0.692).The combination of APTw and T2 mapping yielded the highest AUC of 0.897(95%<i>CI</i>=0.789-0.961),which was higher than that of APTw and T2 mapping alone(<i>P</i>=0.042,<i>P</i>=0.025,respectively). Conclusions APTw and T2 mapping are valuable in assessing the MSI of endometrial adenocarcinoma,and the combination of the two demonstrates higher diagnostic efficacy,thus providing a basis for the selection of preoperative therapeutic modalities for the patients.</p>","PeriodicalId":6919,"journal":{"name":"中国医学科学院学报","volume":" ","pages":"947-953"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144635891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Chili Intake and Cognitive Function in the Elderly Population and the Modifying Effect of Body Mass Index.","authors":"Lu Yuan, Nan Yang, Xing-Yu Zhang, Hai-Yu Yan, Xin-Yang Dui, Xiao-Xue Liu, Tian-Pei Ma, Jin-Yu Xiao, Yu Liang, Jia-Yuan Li","doi":"10.3881/j.issn.1000-503X.16574","DOIUrl":"https://doi.org/10.3881/j.issn.1000-503X.16574","url":null,"abstract":"<p><p>Objective To explore the association between dietary chili intake and cognitive function in the elderly population and the modifying effect of body mass index. Methods On the basis of the baseline survey data of the West China Elderly Health Cohort,a cross-sectional design was adopted,and 1 961 older adults aged 60 and above who had completed a dietary survey were included in this study.Multivariate linear regression and multivariate Logistic regression models were used to explore the associations of chili intake with cognitive function score and cognitive decline,respectively.Stratified analysis was performed to explore whether the associations varied among different body mass index groups. Results Among the surveyed older adults,1 119(57.06%) were diagnosed as with cognitive decline by minimum mental state examination.The results of multivariate linear regression analysis showed that after adjusting for possible confounding factors in turn,the score of chili intake had a stable positive correlation with cognitive function score(<i>β</i>=0.086,95%<i>CI</i>=0.010-0.163,<i>P</i>=0.027).Compared with those who did not have chili intake,the following groups had increased cognitive function scores:those with low chili intake(<i>β</i>=0.559,95%<i>CI</i>=0.023-1.096,<i>P</i>=0.041) or moderate chili intake(<i>β</i>=0.641,95%<i>CI</i>=0.075-1.207,<i>P</i>=0.026),those who had chili intake 1-5 days per week(<i>β</i>=0.994,95%<i>CI</i>=0.430-1.558,<i>P</i>=0.001),those who began chili intake over the age of 18(<i>β</i>=0.797,95%<i>CI</i>=0.172-1.422,<i>P</i>=0.013),those who began chili intake at the age of 18 and under(<i>β</i>=0.476,95%<i>CI</i>=0.045-0.907,<i>P</i>=0.031),those had mild chili intake(<i>β</i>=0.471,95%<i>CI</i>=0.047-0.896,<i>P</i>=0.030),and those who had high chili intake(<i>β</i>=0.982,95%<i>CI</i>=0.275-1.689,<i>P</i>=0.007).Logistic regression analysis showed that chili intake 1-5 days per week(<i>OR</i>=0.634,95%<i>CI</i>=0.474-0.849,<i>P</i>=0.002) was associated with a lower risk of cognitive decline than those without chili intake.Stratified analysis showed that the positive association between chili intake and cognitive function was more significant in the group with body mass index ≥24 kg/m²,and the higher score of chili intake corresponded to the lower risk of cognitive decline(<i>OR</i>=0.924,95%<i>CI</i>=0.875-0.975,<i>P</i>=0.004). Conclusions Appropriate chili intake may have a protective effect on cognitive function in the elderly population,especially in the overweight and obese elderly.Prospective studies are needed to further verify the causal relationship.</p>","PeriodicalId":6919,"journal":{"name":"中国医学科学院学报","volume":"47 6","pages":"888-895"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145916293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research Progress of Non-Thyroidal Illness Syndrome in Sepsis.","authors":"Ya-Qian Qu, Hui-Ling Zang, Zheng-Hao Zhou, Hui Guo, Jian-Guo Li","doi":"10.3881/j.issn.1000-503X.16534","DOIUrl":"https://doi.org/10.3881/j.issn.1000-503X.16534","url":null,"abstract":"<p><p>Non-thyroidal illness syndrome(NTIS)is commonly observed in critically ill patients.Sepsis is one of the leading causes of mortality among patients in intensive care units,where the incidence of NTIS is higher than that in general wards.Recently,increasing attention has been paid to thyroid metabolic abnormalities in sepsis patients.This article reviews the pathogenesis and clinical significance of NTIS in sepsis,aiming to offer evidence-based medical insights for future research directions for clinicians.</p>","PeriodicalId":6919,"journal":{"name":"中国医学科学院学报","volume":"47 6","pages":"1015-1027"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145916390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research Progress in the Roles of Influenza A H1N1 Virus and Its Vaccine in the Pathogenesis of Narcolepsy Type 1.","authors":"Wen-Ting Ding, Jing-Yao Gao, Ze-Liang Guo, Ling-Hui Li, Rong-Zeng Liu","doi":"10.3881/j.issn.1000-503X.16463","DOIUrl":"https://doi.org/10.3881/j.issn.1000-503X.16463","url":null,"abstract":"<p><p>Narcolepsy type 1(NT1) is a chronic sleep disorder caused by the specific depletion of hypocretin(HCRT) neurons.The pathogenesis of NT1 involves human leukocyte antigen(HLA)-related genes(most NT1 patients carry the HLA-DQB1*06∶02 allele) and environmental factors.In Europe,there was a notable increase in NT1 cases among children and adolescents following the H1N1 pandemic in 2009 and 2010,particularly associated with the Pandemrix vaccination.Similarly,in China,the surge in NT1 incidence has been linked to H1N1 virus infections.It has been postulated that H1N1 virus infection may be a predisposing factor for NT1 development.In susceptible individuals,the confluence of the immune response triggered by the Pandemrix vaccine and the H1N1 virus infection could instigate autoimmunity against HCRT,leading to the loss of HCRT neurons mediated by T cells.This paper examines the involvement of influenza A H1N1 virus and its vaccines in the pathogenesis of NT1.</p>","PeriodicalId":6919,"journal":{"name":"中国医学科学院学报","volume":"47 6","pages":"997-1005"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145916400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}